KR101681073B1 - Cosmetic composirion comprising lipid capsule and the preparation method thereof - Google Patents

Cosmetic composirion comprising lipid capsule and the preparation method thereof Download PDF

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Publication number
KR101681073B1
KR101681073B1 KR1020150089421A KR20150089421A KR101681073B1 KR 101681073 B1 KR101681073 B1 KR 101681073B1 KR 1020150089421 A KR1020150089421 A KR 1020150089421A KR 20150089421 A KR20150089421 A KR 20150089421A KR 101681073 B1 KR101681073 B1 KR 101681073B1
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South Korea
Prior art keywords
skin
capsule
moisturizing
present
butter
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KR1020150089421A
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Korean (ko)
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노향선
강계홍
조자운
심은지
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주식회사 나우코스
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11Encapsulated compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Abstract

The present invention relates to a cosmetic composition containing a capsule, and a method for producing the same, wherein the cosmetic composition contains 1 to 20 w/w% of behenyl alcohol, 0.05 to 5 w/w% of a thickening agent, 1 to 20 w/w% of a moisturizing component, and a refractory active ingredient. A refractory active ingredient in a capsule abiogenetically produced during a production process is stabilized, and thus not only a skin epidermal layer but also an endocuticle layer are absorbed. Through effects in moisturizing skin, increasing moisture holding capacity, and reinforcing skin barriers by increasing skin absorbing power, skin conditions can be modified to be healthy. At low speed rpm of an Agi mixer, a capsule shape having an expected size is produced and is cooled to 40C. Accordingly, a lipid capsule having a more stable and constant size can be obtained.

Description

[0001] The present invention relates to a cosmetic composition containing a lipid capsule and a preparation method thereof,

The present invention relates to a composition comprising 1 to 20 w / w% of a behenyl alcohol; 0.05 to 5 w / w%; 1 to 20 w / w% of a moisturizing component; And an insoluble active ingredient, and a process for producing the same.

Cosmetics are classified into various categories according to the use site, purpose of use, or the constitutional components and shapes of the product, and they are classified into various cosmetics such as basic cosmetics, makeup cosmetics, body care cosmetics, hair care cosmetics, oral cosmetics, Can be divided.

Basic cosmetics are defined as those which clean the skin and sufficiently moisturize the stratum corneum, and are classified into toner, emulsion, serum and cream. Toner helps skin texture and emulsion called lotion smoothes skin, prevents moisture evaporation of skin and improves creaminess. Serum is an essence, which keeps the skin homeostatic. It protects the skin from dryness and roughness. The cream is the last step of basic care. The effectiveness of the cream is to protect the stressed skin.

In recent cosmetics industry, various emulsifying techniques such as nano emulsification, multiple emulsification, liquid crystal emulsification and picking emulsification have been applied to cosmetics as means for differentiating appearance of product and transferring effective ingredient. Research into the application of nanostructured particles, which are biocompatible and capable of enhancing the transfer efficiency of materials, has been actively conducted by encapsulating efficants in nanoparticles such as liposomes or cubosomes.

In this connection, the capsule-containing composition dispersed in an aqueous solvent is preferably composed of one or more components selected from the group consisting of a higher alcohol having 16 or more carbon atoms and a glycerin fatty acid ester eicosanic diacid condensate in the oily capsules Wherein the composition essentially contains behenyl alcohol, is contained in an amount of 5 to 40% by weight of the capsule composition, and further contains a water-soluble polymer in an aqueous solvent. However, since the behenyl alcohol is contained in a relatively high amount of 5 to 40% by weight in the above-mentioned technology, the content of the other active ingredients is relatively small and thus commercialization of the cosmetic cosmetic is limited.

On the other hand, at least one functional active ingredient selected from the group consisting of 7-dihydrocholesterol, retinol, and an oil soluble licorice extract is collected therein, and the candelilla wax, behenyl alcohol, butyl alcohol, glyceryl stearate SE and ceresin wax , And at least one kind of solid wax selected from the group consisting of water-in-oil and water-in-oil. However, the above-mentioned technique aims to easily solubilize a poorly soluble substance and formulate an unstable substance such as vitamin A so that its activity and color are not denatured in a cosmetic.

Among the active ingredients listed as raw materials for functional cosmetics, there are many substances that are chemically unstable due to moisture, oxygen, heat, and the like. Among them, there is a method of absorbing vitamin C and vitamin E through chemical derivatization. However, since the original effective ingredient and chemical ingredient are different substances, there is a disadvantage that it is difficult to expect the same efficacy, and the content of the active ingredient Limited. In addition, these emulsifying techniques have a disadvantage that they are expensive and time consuming.

Accordingly, the present invention provides a cosmetic composition which can be most stably absorbed into the skin while maximally protecting the active ingredient of the cosmetic product, and the content of the applicable active ingredient is not limited, and the lipid, which is naturally produced during the production process, To obtain a cosmetic composition in the form of a capsule.

Japanese Patent No. 4,798,899 (registered on Aug. 12, 2011) Korean Patent Publication No. 2010-0039937 (disclosed on Apr. 19, 2010) Korean Laid-Open Patent No. 2013-0038557 (disclosed on March 18, 2013) Korean Public Patent No. 2012-0017285 (Feb. 28, 2012) U.S. Published Patent Application No. 2014-0288191 (disclosed on September 9, 2014) Korean Patent Publication No. 2015-0049191 (Published May 5, 2015)

More particularly, the present invention relates to a cosmetic composition in the form of a lipid capsule and a method for producing the same, and more particularly to a lipid capsule composition which stabilizes an insoluble active ingredient in capsules naturally produced during the production process, The present invention provides a cosmetic composition in the form of a lipid capsule which improves the skin condition through an action of increasing the water holding capacity, a skin barrier strengthening effect by increasing the skin absorption power, a moisturizing effect and the like.

In order to achieve the above object, the present invention relates to a method for preparing a capsule by dissolving a high-alcohol such as behenyl alcohol in a moisturizing oil such as Shea butter and Meadouform seed oil to form a capsule, Acrylate / C10-30 alkyl acrylate crosspolymer and sodium polyacrylate starch to control and stabilize the flow of the formulation to absorb not only the skin layer but also the inner epidermal layer so that the skin moisturizing supply action, The present invention has been accomplished by providing a cosmetic composition in the form of a lipid capsule which improves the skin condition through a skin barrier enhancement effect, a moisturizing effect, and the like.

Further, a mixture of the behenyl alcohol, the thickening agent, the moisturizing component and the poorly soluble active ingredient is formed into a capsule-sized form which is expected by using a low speed rpm such as an Agi Mixer, and then cooled to 40 캜 or lower, Capsules can be prepared.

A lipid capsule containing an enhancing agent such as a high alcohol such as behenyl alcohol of the present invention, a moisturizing component such as shea butter, meadow fodder seed oil, etc., an acrylate / C10-30 alkyl acrylate cross polymer and sodium polyacrylate starch The cosmetic composition of the present invention stabilizes an insoluble active ingredient in capsules naturally formed during the production process, absorbing not only the skin layer but also the inner skin layer, thereby increasing the skin moisturizing supply action, increasing the water holding capacity and enhancing skin barrier Effect, and moisturizing effect can be provided.

FIG. 1 is a photograph of a capsule according to Example 1 of the present invention. Capsule size was measured at 150 to 460 占 퐉.
FIG. 2 is a photograph of a capsule according to Example 2 of the present invention. Capsule size was measured at 300 to 700 占 퐉.
FIG. 3 is a photograph of a capsule according to Example 3 of the present invention. Capsule size was measured at 900 to 1,400 .mu.m.

The present invention relates to a thickening agent such as an acrylate / C10-30 alkyl acrylate crosspolymer and sodium polyacrylate starch, a thickening agent such as behenyl alcohol and a thickening agent such as shea butter, meadow foam Unlike capsules, which contain moisturizing ingredients such as seed oil and are artificially added, they are naturally generated during the manufacturing process to stabilize the insoluble active ingredient in the capsule, thereby increasing the skin moisturizing supply action, increasing the water holding capacity, A skin barrier enhancement effect through the skin, and a moisturizing effect.

The present invention includes a high alcohol such as behenyl alcohol to form capsules spontaneously during the manufacturing process to stabilize the insoluble active ingredient in the capsules and to provide an acrylate / C10-30 alkyl acrylate crosspolymer and sodium polyacrylate A lipid capsule type cosmetic composition which improves the flow control and stability of the formulation by containing an incremental agent such as starch and improves the skin condition by enhancing skin barrier and moisturizing effect by containing shea butter and meadow form seed oil Composition can be provided.

Hereinafter, the present invention will be described in more detail.

Unless otherwise indicated, all percentages and ratios in this specification are by weight.

The present invention relates to a composition comprising 1 to 20 w / w% of a behenyl alcohol; 0.05 to 5 w / w%; 1 to 20 w / w% of a moisturizing component; And a poorly soluble active ingredient.

In one embodiment of the present invention, behenyl alcohol is used in an amount of 3 to 10 w / w%; From 0.1 to 2 w / w%; The moisturizing component may be included in an amount of 5 to 10 w / w%.

The behenyl alcohol used in the present invention is an aliphatic hydrocarbon derivative having 22 carbons. Behenyl alcohol, a natural fatty alcohol component, can be obtained from coconut and palm oil and is a water-insoluble component with the appearance of white flakes, particles or lumps. It is a natural non-chemical ingredient that helps to maintain moisture in your skin by preventing loss of moisture in your skin. It helps to soften your skin and smooth your skin.

The behenyl alcohol which is characteristically used in the present invention is used in an amount of about 1 w / w% to about 20 w / w%, and when it is 1 w / w% or less, capsules are scarcely formed and more than 20 w / If it is not a capsule type cream, it becomes an emulsion type general cream. Thus, the present invention provides a composition comprising from about 1 w / w% to about 20 w / w%, preferably from about 1 w / w% to about 10 w / w%, more preferably from 1 w / It is most appropriate to use it less than.

In one aspect of the invention, the incremental zero is selected from the group consisting of acrylate / C10-30 alkyl acrylate crosspolymer, sodium polyacrylate starch, magnesium silicate, xanthan gum, carbomer, carrageenan, alginic acid, pectin, starch, polyglyceryl meta At least one member selected from the group consisting of polyvinylpyrrolidone, polyvinylpyrrolidone, acrylate, carboxyvinyl polymer, polyvinylpyrrolidone, carboxymethylcellulose, hydroxyethylcellulose, ethylhydroxyethylcellulose and methylhydroxyethylcellulose, or a combination of two or more thereof May be used. More specifically, an acrylate / C10-30 alkyl acrylate crosspolymer, sodium polyacrylate starch, or a combination thereof may be used.

The enhancer used in the present invention is a substance used for increasing the viscosity of a cosmetic product and can improve the feel and stability of the product. The thickener uses a usable polymer material among the polymer materials. Magnesium silicate is typically used as an inorganic thickener, and organic thickeners include natural polymers (carrageenan, alginic acid, pectin, starch), semisynthetic polymers (carboxymethylcellulose), synthetic polymers (carboxyvinyl polymer, polyvinylpyrrolidone) .

The incremental acrylate / C10-30 alkyl acrylate crosspolymer used in the present invention is one or more of simple esters or acrylic acid crosslinked with allyl ether of sucrose or allylether of pentaerythritol, It is a copolymer component of one or more monomers consisting of one C10-30 alkyl acrylate.

The acrylate / C10-30 alkyl acrylate crosspolymer is used as a water-soluble or water-insoluble thickener to control the viscosity of the formulation. It forms a thin film on the skin or hair, smoothly wraps it, facilitates the care and management of the skin and hair, and is used as a raw material to stabilize the unstable emulsion state of the formulation.

The incremental sodium polyacrylate starch used in the present invention is a water-soluble thickening agent of sodium acrylate polymer-bound starch and is an enhancer used in making formulations such as mousse.

The sodium polyacrylate starch has the ability to store up to 400 times its own weight of water and is an additive that helps maintain moisturization and has excellent stability at high temperatures and a wide range of pH.

The weight sum of the acrylate / C10-30 alkyl acrylate crosspolymer and sodium polyacrylate starch characteristically used in the present invention is about 0.05 w / w% to about 5 w / w%, preferably 0.05 w / w %, The effect of scaling up is small, and when it is 5 w / w% or more, it becomes very difficult to manufacture due to high viscosity of the gel phase. Therefore, it is most appropriate to use the present invention at about 0.05 w / w% to about 5 w / w%, preferably about 0.1 w / w% to about 2 w / w%.

In one aspect of the present invention, the moisturizing ingredient may include moisturizing ingredients such as shea butter, extra virgin olive oil, olive oil, olive butter, chamomile extract, jojoba butter (jojoba ester), mango seed butter, raspberry butter, avocado butter, , Peach butter, pistachio butter, coconut butter, cocoa butter, pomegranate butter, rose hip butter, sunflower butter, malt butter, apricot butter, babassu butter, cupuacu butter, kokum Butter, hazelnut butter, sesame butter, soya butter, almond butter, meadowfoam seed butter, black current seed butter, cranberry butter, grape seed oil, sunflower seed oil, meadowfoss seed oil, jojoba oil , Coconut oil, almond oil, palm oil, camellia oil, green tea seed oil Polyquaternium-6. Polyquaternium-7, polyquaternium-10, polyquaternium-44 or polyquaternium-51, phage-8 dimethicone, phage-9 dimethicone, phage-10 dimethicone, One or more selected from the group consisting of dimethicone, phage-20, phage-150, phage / phage 17/6 copolymers, and phage / phage 18/4 copolymers, And more specifically, a moisturizing ingredient such as shea butter or meadowfoam seed oil can be used.

The moisturizing agent used in the present invention is an important function of cosmetics. Maintaining a moisture content suitable for skin is an important factor for determining the quality of cosmetics. Moisturizers used in cosmetics can be roughly divided into Moisturizer, Humectant, and Emollient. Moisturizers are ingredients that make up or keep moisture in your skin, and are often used as cosmetic product names. It prevents moisture evaporation of the skin and provides moisture to the skin to provide flexibility and softness to the skin.

Typical moisturizing agents include polyols, natural moisturizing factor components, and polymeric substances that can contain water. Humectant is a hygroscopic agent. Because it attracts moisture, it is used not only for cosmetics but also for food additive and plastic coating. When used in cosmetics, it has the function of attracting moisture in the air and storing and storing it for a long time to stay on the skin. If there is not enough moisture in the surrounding environment, not only can the moisturizing effect be reduced, but it can also take away the moisture of the skin and make the skin rough and dry. Humectant is a non-oily ingredient and glycerin, propylene glycol, and glyceryl triacetate are widely used. Emollients are called softeners and softeners. It softens the skin by creating a film that blocks moisture evaporation from the skin surface. It does not have the function of absorbing and sucking moisture, and makes the skin soft by allowing the water to evaporate slowly. If the skin does not lose moisture, it will remain soft, moist and smooth. Oils and waxes, and animal oils, mineral oils, vegetable oils, cocoa butter, and fatty alcohols.

In the present invention, the sum of the weight of shea butter and meadowfoam seed oil used is about 1 w / w% to about 20 w / w%, and when it is less than 1 w / w% If it is more than about 20 w / w%, the oily feeling is too much, sticky, and it is difficult to form a desired formulation. The present invention is most suitably used at about 1 w / w% to about 20 w / w%, preferably about 5 w / w% to about 10 w / w%.

In one embodiment of the present invention, the diameter of the capsules contained in the capsule-containing composition is in the range of 100 to 1,000 mu m.

In one embodiment of the present invention, the capsule containing cosmetic composition may be any one selected from the group consisting of lotion, skin, toner, essence, ampule, emulsion, gel, cleansing water, pack, cream and eye cream.

The present invention also relates to a composition comprising 1 to 20 w / w% of a behenyl alcohol; 0.05 to 5 w / w%; 1 to 20 w / w% of a moisturizing component; And an insoluble active ingredient; Stirring the mixture; And cooling the mixture to a temperature of 40 DEG C or lower.

In one embodiment of the present invention, a capsule-sized form is prepared in which a mixture of the behenyl alcohol, the thickening agent, the moisturizing component and the insoluble active ingredient is expected to be obtained using a low speed rpm such as an Agi Mixer, , A more stable lipid capsule can be produced.

In one embodiment of the present invention, behenyl alcohol is used in an amount of 3 to 10 w / w%; From 0.1 to 2 w / w%; A method for producing a capsule-containing cosmetic composition, wherein the moisturizing component is contained in an amount of 5 to 10 w / w%, is also provided.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, the following examples are intended to assist the understanding of the present invention and are not intended to limit the scope of the present invention thereto.

Examples and Comparative Examples. Preparation of capsule-containing cosmetic composition

As shown in Table 1 below, each ingredient was added, and the mixture was heated to about 60 ° C. The mixed solution was stirred at 300 rpm / min for 1 minute. Thus, a capsule-containing cosmetic material was obtained.

Raw material name Comparative Example 1 Example 1 Example 2 Purified water Suitable amount Suitable amount Suitable amount EDTA-2Na 0.02 0.02 0.02 Butylene glycol 5.0 5.0 5.0 Acrylate / C10-30 alkyl acrylate crosspolymer 0.05 0.05 Sodium polyacrylate starch 0.05 0.05 C18 ~ 24 Advanced Alcohol 5.0 10.0 C12 ~ 16 high alcohol 5.0 Alpha-Bisabolol 0.5 0.5 0.5 Sheer butter 2.0 2.0 Meadow Foam Seed Oil 5.0 5.0 pH adjusting agent Suitable amount Suitable amount Suitable amount antiseptic Suitable amount Suitable amount Suitable amount incense Suitable amount Suitable amount Suitable amount

Test Example 1. Comparison of the moisturizing effect according to the contents of C18 ~ 24 higher alcohol

Twenty Korean women (25 to 35 years old) were applied to the skin to check the skin condition, in the form of lipid capsules having the compositions of the above Comparative Examples and Examples 1 and 2. Table 2 shows the feel of the cream in the form of a lipid capsule and the degree of moisturizing effect of the skin after application to the skin. The evaluation criteria were 1 (very unsatisfactory) to 10 (very satisfied) and the results are shown in Table 2.

Evaluation of Lipid Capsule Cream Use Item Comparative Example 1 Example 1 Example 2 Feeling 5.5 9.0 9.7 Moisture power 5.2 9.0 9.4

Claims (8)

1 to 5 w / w% of behenyl alcohol;
0.05 to 5 w / w%;
1 to 20 w / w% of a moisturizing component; And
Containing purified water
Wherein the thickener comprises an acrylate / C10-30 alkyl acrylate crosspolymer and sodium polyacrylate starch, wherein the moisturizing component comprises shea butter and meadowfoam seed oil. .
delete delete delete delete delete 1 to 5 w / w% of behenyl alcohol; 0.05 to 5 w / w%; 1 to 20 w / w% of a moisturizing component; And refining the remaining water;
Stirring the mixture; And
RTI ID = 0.0 > 40 C < / RTI >
Wherein the thickener comprises an acrylate / C10-30 alkyl acrylate crosspolymer and sodium polyacrylate starch, wherein the moisturizing component comprises shea butter and meadowfoam seed oil. ≪ / RTI >
delete
KR1020150089421A 2015-06-24 2015-06-24 Cosmetic composirion comprising lipid capsule and the preparation method thereof KR101681073B1 (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102105256B1 (en) * 2018-12-05 2020-04-29 (주) 에이텍 Cosmetic composition containing Taeniam extracts wrapped in cubic phase lipidic nanostructure for sensitive skin care and thereof producing method
KR20200083776A (en) 2018-12-28 2020-07-09 주식회사 케이피티 Method of preparing oil dispersed double capsule and oil dispersed double capsule prepared thereby
KR20210012350A (en) * 2019-07-25 2021-02-03 라미령 Artificial layer cream composition having superior moisture retention and skin penetration effect by nanoliposome treatment method
KR20210012349A (en) * 2019-07-25 2021-02-03 라미령 Cosmetic composition forming breathable protein membrane that effectively absorbs active ingredient while blocking moisture evaporation of skin
KR102539384B1 (en) * 2022-06-20 2023-06-05 (주)나우코스 Cosmetic composition containing pigment capsules with maximized stability

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KR20100039937A (en) 2008-10-09 2010-04-19 한불화장품주식회사 Preparation of microcapsule loaded with active materials and cosmetic composition containing the microcapsule
JP4798899B2 (en) 2001-08-29 2011-10-19 株式会社 資生堂 Capsule-containing external composition
KR20120017285A (en) 2010-08-18 2012-02-28 (주)아모레퍼시픽 Cosmetic composition having excellent moisturizing effect for the skin
KR20130038557A (en) 2011-10-10 2013-04-18 주식회사 코리아나화장품 Cosmetic composition containing amorphous beads and method thereof
US20140288191A1 (en) * 2011-09-16 2014-09-25 Amorepacific Corporation Inner phase thickened water-in-oil cosmetic composition
KR20150049191A (en) 2013-10-29 2015-05-08 주식회사 엘지생활건강 Skin whitening cosmetic compositions

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JP4798899B2 (en) 2001-08-29 2011-10-19 株式会社 資生堂 Capsule-containing external composition
KR20100039937A (en) 2008-10-09 2010-04-19 한불화장품주식회사 Preparation of microcapsule loaded with active materials and cosmetic composition containing the microcapsule
KR20120017285A (en) 2010-08-18 2012-02-28 (주)아모레퍼시픽 Cosmetic composition having excellent moisturizing effect for the skin
US20140288191A1 (en) * 2011-09-16 2014-09-25 Amorepacific Corporation Inner phase thickened water-in-oil cosmetic composition
KR20130038557A (en) 2011-10-10 2013-04-18 주식회사 코리아나화장품 Cosmetic composition containing amorphous beads and method thereof
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102105256B1 (en) * 2018-12-05 2020-04-29 (주) 에이텍 Cosmetic composition containing Taeniam extracts wrapped in cubic phase lipidic nanostructure for sensitive skin care and thereof producing method
KR20200083776A (en) 2018-12-28 2020-07-09 주식회사 케이피티 Method of preparing oil dispersed double capsule and oil dispersed double capsule prepared thereby
KR20210012350A (en) * 2019-07-25 2021-02-03 라미령 Artificial layer cream composition having superior moisture retention and skin penetration effect by nanoliposome treatment method
KR20210012349A (en) * 2019-07-25 2021-02-03 라미령 Cosmetic composition forming breathable protein membrane that effectively absorbs active ingredient while blocking moisture evaporation of skin
KR102267189B1 (en) * 2019-07-25 2021-06-18 라미령 Cosmetic composition forming breathable protein membrane that effectively absorbs active ingredient while blocking moisture evaporation of skin
KR102267190B1 (en) * 2019-07-25 2021-06-22 라미령 Artificial cream layer composition having superior moisture retention and skin penetration effect by nanoliposome treatment method
KR102539384B1 (en) * 2022-06-20 2023-06-05 (주)나우코스 Cosmetic composition containing pigment capsules with maximized stability

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