KR20110058240A - Nanoemulsion containing high content of hydrophobic ingredients and the method for preparing thereof - Google Patents

Abstract

PURPOSE: A nanoemulsion cosmetic composition of transparent or suspension liquid phase is provided to prevent skin dryness and to maintain soft skin. CONSTITUTION: A nanoemulsion cosmetic composition contains 4-12 weight% of hydrophobic ingredient containing liquid phase and solid phase hydrophobic ingredients in a weight ratio of 1:0.5-1.5. The liquid phase hydrophobic ingredient is oil, ester, hydrocarbon, or silicon. The solid phase hydrophobic ingredient is lipid, wax, higher alcohol, higher fatty acid, or hydrocarbon. A method for manufacturing the nanoemulsion cosmetic comprises: a step of mixing the liquid phase and solid phase hydrophobic ingredients in a weight ratio of 1:0.5-1.5; and a step of treating the mixture 3-8 times at 500-1,500 bar.

Description

Nanoemulsion containing high content of hydrophobic ingredients and method for preparing the same

The present invention relates to a transparent or suspended liquid nanoemulsion cosmetic composition prepared using a high-pressure emulsifier and a method for producing the same, and more particularly, to a high content of the oil-soluble component in which the liquid and solid oil-soluble components are mixed in a specific content ratio. The present invention relates to a transparent or suspended liquid nanoemulsion cosmetic composition and a method for producing the same, which enhance the skin barrier function to prevent dryness of the skin and keep it soft and moist.

A general method of making a lotion is to dissolve a moisturizer, a thickener, etc. in purified water to form an aqueous phase, to dissolve a solubilizer and a fragrance in ethanol to form an ethanol, and then stir the ethanol phase to the aqueous phase and stir it sufficiently to make it transparent or suspended. It is made of liquid in the state. However, such a lotion is mainly composed of hydrophilic moisturizers, there is a limit to balance the oil and moisture of the skin, there is still a consumer dissatisfaction with the basic stickiness and lack of moisturizing persistence by water-soluble moisturizers. In addition, in most cases, ethanol is used as a solvent to effectively dissolve and solubilize fragrances, solubilizers and small amounts of oil-soluble ingredients that are not easily soluble in water. It can also provide a burning stimulus.

On the other hand, highly moisturizing lotion by preparing a nanoemulsion containing a large amount of oil-soluble components by using the phase-phase emulsification method, which can easily prepare fine emulsion particles with relatively little energy due to the extremely low interfacial tension between oil-surfactant and water. Or how to make an emulsion is introduced ( Inter . J. Cosmet . Sci . 1994 , 16 , 84-92). However, in order to prepare a stable nanoemulsion through the phase-phase emulsification method known as the CAPICO method, there are limitations on the type and content of useful components and emulsifiers to be used. Therefore, in order to calculate the optimum phase temperature range that can ensure the long-term stability to the maximum, it is necessary to calculate the optimum emulsifier type and content for the useful components to be used by using a specially designed calculation formula. However, the type and content of emulsifiers calculated by the CAPICO method only suggest a starting point for conducting experiments, and if these CAPICO methods cannot be helped, they must undergo considerable trial and error experimentally.

Accordingly, the present inventors have been devoted to the study of the composition of the high-moisturizing nanoemulsion cosmetic composition using the high pressure emulsification method, while having a relatively high content of the oil-soluble component of 4 to 12% by weight, it has a transparent or suspended liquid appearance, The present invention has been completed and found that the clear or suspended liquid can be converted into an opaque emulsion as applied to the skin to provide a differentiated use experience that is absorbed by the skin.

Accordingly, it is an object of the present invention to provide a nanoemulsion cosmetic composition and a method of manufacturing the same that can enhance the function of the skin barrier to prevent skin dryness and provide excellent moisturizing effect.

In order to achieve the above object, the present invention provides a nano-emulsion cosmetic composition containing 4 to 12% by weight relative to the total weight of the cosmetic composition of the oil-soluble component of the liquid and solid oil-soluble components in a weight ratio of 1: 0.5 to 1.5. do.

In the present invention, 1) mixing the liquid and solid oil-soluble components in a weight ratio of 1: 0.5 to 1.5; And 2) adding the mixture of 1) to a high pressure emulsifier and repeating the pressure emulsification process 3 to 8 times at a pressure of 500 to 1,500 bar to provide a method for producing a nanoemulsion cosmetic.

The nanoemulsion cosmetic composition according to the present invention is prepared as a transparent or suspended liquid containing a solid oil-soluble component of a high content ratio compared to the liquid-soluble component, thereby reducing the transdermal moisture loss, giving an excellent skin moisturizing effect, and transparent or suspended when applying the skin. The appearance of the liquid was converted to a milky white opaque appearance to give a differentiated feeling of absorption into the skin.

The present invention relates to a transparent or suspended liquid nanoemulsion cosmetic composition prepared using a high pressure emulsifier and a method for producing the same.

The transparent or suspended liquid nanoemulsion cosmetic composition according to the present invention is used by mixing the liquid and solid oil-soluble components in a weight ratio of 1: 0.5 to 1.5, wherein the total content of the liquid and solid oil-soluble components is 4 to the total weight of the cosmetic composition. It is characterized by being contained in -12 weight%. In this case, when the content of the solid-use oil-soluble component is less than the content ratio, it is difficult to identify a phenomenon in which a liquid of a transparent or suspended liquid is converted to an milky white opaque emulsion when applied to the skin, and when the content ratio is greater than the prepared nano Problems may arise with stability of the emulsion over time.

In addition, if the total content of the oil-soluble component is less than 4% by weight, sufficient oil and water balance may be broken, and if it exceeds 12% by weight, it is transparent because an emulsion of a completely opaque appearance having a particle size of 1 μm or more is formed. It is also difficult to obtain nanoemulsions of suspended appearance.

The solid oil-soluble component used in the present invention may have a melting point of 30 ° C. or higher and at least one kind selected from the group consisting of fats, waxes, higher alcohols, higher fatty acids, and hydrocarbons. For example, fats such as shea butter, manco seed butter and cacao seed butter; Waxes such as carnauba wax, candelilla wax, and beeswax; Higher alcohols such as cetyl alcohol, stearyl alcohol and behenyl alcohol; Higher fatty acids such as lauric acid, myristic acid, palmitic acid and stearic acid; And it may contain one or more selected from the group consisting of hydrocarbons, such as paraffin, ceresin and microcrystalline wax, but is not limited thereto.

The liquid oil-soluble component used in the present invention may be at least one selected from the group consisting of oils, esters, hydrocarbons and silicones. For example, oils, such as meadowfoam seed oil, sunflower seed oil, macadamia seed oil, green tea seed oil, and camellia oil; Esters such as cetylethylhexanoate, octyldodecyl myristate, pentaerythrityl tetraethylhexanoate, isopropyl palmitate and isopropyl myristate; Hydrocarbons such as liquid paraffin, squalane, isohexadecane, hydrogenated polydecene and hydrogenated polyisobutene; And one or more selected from the group consisting of silicones such as cyclomethicone, dimethicone and phenyltrimethicone, but is not limited thereto.

The emulsion cosmetic composition according to the present invention may further contain at least one emulsifier selected from the group consisting of lecithin, nonionic surfactants and anionic surfactants in addition to the oil-soluble component. For example, lecithins, such as lecithin, hydrogenetirescitin, lyso lecithin, and hydrogenatidriole lecithin; Polysorbate 60, Fiji-40 Stearate, Octyldodeces-25, Ceteares-20, Fiji-20 Glycerylisostearate, Polyglyceryl-3 Methylglucose distearate, Cetearylglucoside, Nonionic surfactants such as inulin lauryl carbamate and polyglyceryl-10 stearate; And it may contain one or more emulsifiers selected from the group consisting of anionic surfactants such as potassium cetyl phosphate, sodium stearoyl glutamate and glyceryl stearate citrate, but is not limited thereto. The emulsifier preferably contains 1.5 to 3.5% by weight based on the total weight of the emulsion composition, when less than 1.5% by weight it is difficult to form a stable nanoemulsion, when exceeding 3.5% by weight will give irritation to sensitive skin Can be.

The method for preparing a nanoemulsion cosmetic according to the present invention includes the following steps:

1) mixing the liquid and solid oil-soluble components in a weight ratio of 1: 0.5 to 1.5; And

2) injecting the mixture of 1) into a high-pressure emulsifier and repeating the pressure-emulsification process 3 to 8 times at a pressure of 500 to 1500 bar.

That is, the nano-emulsion cosmetics according to the present invention can be prepared by repeating the high-pressure emulsification treatment 3 to 8 times at a pressure of 500 to 1500 bar using a high pressure emulsifier, preferably 4 to 6 times at a pressure of 800 to 1,200 bar. Repeated autoclaving can produce nanoemulsions with an average particle size of 50-200 nm. When performing high pressure emulsification, in case of repeated high pressure emulsification treatment with a pressure of less than 500 bar, the average particle size of the prepared nanoemulsion is 300 nm or more and the distribution of the particle size is very wide so that it can be creamed within one month after production. Phenomenon occurs and repeated high pressure emulsification in excess of 8 times with a pressure of more than 1,500 bar has no special advantage in terms of productivity because there is no significant improvement in particle size and particle size distribution.

The nanoemulsion cosmetics according to the present invention provide a transparent or suspended liquid appearance during preparation by containing a large amount of the solid oil-soluble component as compared to the liquid oil-soluble component, but is characterized by being converted into an opaque milky opaque emulsion when applied to the skin. Due to the high content of the solid oil-soluble component, it effectively strengthens the skin barrier function when applying the skin, thereby effectively preventing skin drying and providing a high moisturizing effect to make the skin soft and moist.

Therefore, the nanoemulsion cosmetic composition in one embodiment of the present invention is a moisturizing cosmetic composition.

The nanoemulsion cosmetic composition according to the present invention is not particularly limited in its formulation, but considering the appearance and advantages of using a transparent or suspended liquid, basic cosmetics such as softening water, nutrient cosmetic water, spray, mist and gel; Cosmetic compositions for hair such as wool, such as hair tonics, hair essences and hair treatments; It can be widely applied to other medicines and quasi-drugs.

Hereinafter, the content of the present invention will be described in more detail through examples and comparative examples. These examples are provided only for understanding the contents of the present invention, but the scope of the present invention is not limited to these examples and test examples, and modifications, substitutions, and insertions commonly known in the art may be performed. It may be included in the scope of the present invention.

[Examples 1-4 and Comparative Examples 1-3]

The nanoemulsion cosmetics of Examples 1-4 and Comparative Examples 1-3 were prepared according to the composition shown in Table 1 (unit: weight%).

ingredient Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Number
Prize
castle
minute Purified water Balance Balance Balance Balance Balance Balance Balance EDTA-2Na 0.02 0.02 0.02 0.02 0.02 0.02 0.02 glycerin 4.00 4.00 4.00 4.00 4.00 4.00 4.00 Butylene glycol 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Glyceres-26 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Methylgluses-20 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Fiji-75 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Trehalose 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Preservative Quantity Quantity Quantity Quantity Quantity Quantity Quantity U
Prize
castle
minute Squalane 2.00 1.00 2.00 4.00 4.00 2.00 5.00 Meadowfoam Seed Oil 1.00 0.50 1.00 1.20 1.00 1.00 2.00 Dimethicone 1.00 0.50 - - 0.50 - 1.00 Shea Butter 2.00 1.00 1.00 0.80 1.50 1.00 1.00 Cetearyl Alcohol 1.50 0.75 1.50 1.00 0.50 2.00 2.00 Behenyl Alcohol 1.50 0.75 0.50 1.00 0.50 2.00 2.00 Potassium cetylphosphate 0.50 0.25 0.20 0.20 0.20 0.20 0.20 Hydrogenated Lecithin 0.50 0.25 1.00 1.50 1.00 1.00 1.50 Polyglycerin-10 Stearate 1.00 0.50 0.70 1.00 1.00 1.00 1.00 Fiji-20glysylisostearate 1.00 0.50 0.50 0.50 1.00 1.00 0.80 incense Quantity Quantity Quantity Quantity Quantity Quantity Quantity

<Manufacturing Method>

1) The aqueous phase components were uniformly mixed at room temperature and heated to 70-75 ° C.

2) The oily ingredients were heated to 70-75 ° C. to uniformly dissolve and mix.

3) The homogenizer was used to emulsify uniformly at 5,000 rpm for 5 minutes while introducing 2) into 1).

4) The 3) was put into a high pressure emulsifier was repeated 5 times high pressure oil at a pressure of 1,000 bar.

5) The above 4) was stored by cooling to room temperature.

Test Example 1 Formulation Observation According to Solid-Soluble Component / Liquid-Soluble Component Ratio

The content ratio of the solid oil-soluble component to the liquid oil-soluble component of Examples 1 to 4 and Comparative Examples 1 to 3 and whether the transparent or suspended liquid liquid during application of the skin is converted into an opaque milky emulsion were examined. . In addition, the stability of the nanoemulsion according to the average particle size of the emulsion and the change over time immediately after the preparation was confirmed, and the results are shown in Table 2 below.

In order to determine the stability of the nanoemulsion according to the change over time, the nanoemulsions prepared in Examples 1 to 4 and Comparative Examples 1 to 3 were circulated at room temperature, 45 ° C. in a thermostatic bath and at −10 ° C. to 45 ° C. at 12 hour intervals. After storage for 1 month in a thermostat, the appearance of the nanoemulsion was observed.

Item Total content of oil soluble ingredients
(weight%) Liquid phase: weight ratio of the solid phase oil-soluble component Average particle size (nm) No change in application Stability Room temperature 45 ℃ cycle 1 week 4 Weeks 1 week 4 Weeks 3 days 1 week Example 1 9.00 1: 1.25 136 U Good Good Good Good Good Good Example 2 4.50 1: 1.25 65 U Good Good Good Good Good Good Example 3 6.00 1: 1.00 83 U Good Good Good Good Good Good Example 4 8.00 1: 0.54 107 U Good Good Good Good Good Good Comparative Example 1 8.00 1: 0.45 94 radish Good Good Good Good Good Good Comparative Example 2 8.00 1: 1.67 123 U Good Good Good detach Good detach Comparative Example 3 13.00 1: 0.62 1,172 radish detach detach detach detach detach detach

In the results of Table 2, in Examples 1 to 4, the average particle size was 60-140 nm, and the stability was observed for 1 month, and it was maintained in a good state, and even when applied to the skin, milky white opaque liquid in suspension liquid was used. It was found to convert to one emulsion. However, in the case of Comparative Example 1, a stable suspension liquid nanoemulsion having a mean particle size of 100 nm or less was prepared, but no change was observed when applied to the skin with a low content of the solid useful component compared to the content of the liquid useful component. Did. In Comparative Example 2, a suspension liquid nanoemulsion having an average particle size of about 120 nm was prepared and was converted into an opaque milky emulsion when applied to the skin, but creaming occurred in a 45 ° C thermostat within 4 weeks. In particular, it was confirmed that the gelation (gelation) occurs after 3 days when stored in a constant temperature bath circulating at intervals of 12 hours from -10 ℃ to 45 ℃. In Comparative Example 3, the ratio of the solid oil-soluble component to the liquid oil-soluble component is 0.5 or more, but the content of the total oil-soluble component is so high that the average particle size of the emulsion prepared immediately after high-pressure emulsification is about 1.3 μm, which gives an opaque milky appearance. Because of this, it was impossible to observe the change in appearance during application to the skin.

Example 5 and Comparative Example 4

According to the composition described in Table 3 below to prepare a nanoemulsion cosmetics of Example 5 and a lotion of Comparative Example 4. In Example 5 and Comparative Example 4, the total content of the water-soluble moisturizing agent and the oil-soluble emollient was fixed at 16 wt%, and the nanoemulsion cosmetic of Example 5 was prepared in the same manner as in Examples 1 to 4 (unit: wt%). .

ingredient Example 5 Comparative Example 4 Number
Prize
castle
minute Purified water Balance Balance EDTA-2Na 0.02 0.02 glycerin 3.00 6.00 Butylene glycol 2.00 4.00 Glyceres-26 1.00 2.00 Methylgluses-20 1.00 2.00 Fiji-75 - 0.50 Trehalose - 1.00 Preservative Quantity Quantity U
Prize
castle
minute ethanol - 3.00 Squalane 2.00 0.20 Meadowfoam Seed Oil 1.00 0.30 Dimethicone 1.00 - Shea Butter 2.00 - Cetearyl Alcohol 1.50 - Behenyl Alcohol 1.50 - Potassium cetylphosphate 0.50 - Hydrogenated Lecithin 0.50 - Fiji-20glysylisostearate 1.00 - Fiji-60 Hydrogenated Castor Oil 1.00 1.0 incense Quantity Quantity

<Production Method of Comparative Example 4>

1) The aqueous phase components were thoroughly mixed by uniform mixing at room temperature.

2) The oily components were completely dissolved by uniform mixing at room temperature.

3) Solubilization was carried out while slowly adding 2) to 1) above using an agitator to obtain a suspended liquid.

Test Example 2 Moisturizing Enhancement Effect of Skin

In order to confirm the skin moisturizing enhancement effect of the cosmetic composition of the present invention, 40 adult women (average 32.8 years old) applied to Example 5 and Comparative Example 4 twice a day for 1 week to the inside of the upper arm Trans Epidermal Water Loss (TEWL) before and after was measured at constant temperature and humidity conditions (24 ° C., 40% RH) to compare moisturizing power, and the average values are shown in Table 4 below.

<Measurement of Trans Epidermal Water Loss (TEWL)>

The amount of water evaporated from the skin was calculated according to the area and time, and the amount of evaporated water was read and quantified by the temperature and moisture electronic sensors to measure the skin's moisturizing power.

1) Environmental conditions: The temperature and humidity were kept constant, and the flow of air was cut off as much as possible, leaving only the minimum number of personnel except the measuring person and the subject.

2) The TEWL probe was placed on the measurement site of the subject. At this time, do not apply excessive force to the measurement site, the probe was placed lightly so as not to leave marks on the skin to form an angle of 90 ° with the ground.

3) The value of the skin's TEWL level is constant over time (usually 1-3 minutes). At this time, the handle of the probe is to be held as far as possible to avoid the body temperature of the measurer.

4) The amount of water evaporated per hour per area (g / m 2 / h) was calculated.

Item TEWL before application
(g / ㎡ / hr) TEWL after application
(g / ㎡ / hr) ΔTEWL
(g / ㎡ / hr) Example 5 15.67 11.15 -4.52 Comparative Example 4 15.03 12.82 -2.21

In the results of Table 4, it was confirmed that the nanoemulsion cosmetics of Example 5 according to the present invention is significantly lower in the decrease in transdermal moisture loss after application than the general dry skin lotion of the suspension liquid of Comparative Example 4. Therefore, it was confirmed that Example 5 according to the present invention is superior to the moisture retention capacity of the skin than Comparative Example 4.

Claims (9)

A nanoemulsion cosmetic composition containing 4 to 12% by weight of an oil-soluble component in which liquid and solid oil-soluble components are mixed in a weight ratio of 1: 0.5 to 1.5 with respect to the total weight of the emulsion composition. The nanoemulsion cosmetic composition according to claim 1, wherein the liquid oil-soluble component is at least one selected from the group consisting of oils, esters, hydrocarbons, and silicones. The nanoemulsion cosmetic composition of claim 1, wherein the solid oil-soluble component is at least one selected from the group consisting of fats, waxes, higher alcohols, higher fatty acids, and hydrocarbons. The nanoemulsion cosmetic composition according to claim 1, wherein the nanoemulsion has a transparent or suspended liquid appearance. The nanoemulsion cosmetic composition of claim 1, wherein the nanoemulsion is converted into a milky white opaque emulsion when applied to the skin. The nanoemulsion cosmetic composition according to any one of claims 1 to 5, wherein the composition is for moisturizing the skin. 1) mixing the liquid and solid oil-soluble components in a weight ratio of 1: 0.5 to 1.5; And 2) injecting the mixture of 1) into a high-pressure emulsifier and repeating the pressure-emulsification process 3 to 8 times at a pressure of 500 to 1500 bar; Nanoemulsion cosmetics manufacturing method comprising a. The method of claim 7, wherein the liquid oil-soluble component is at least one selected from the group consisting of oils, esters, hydrocarbons, and silicones. The method of claim 7, wherein the solid oil-soluble component is at least one selected from the group consisting of fats, waxes, higher alcohols, higher fatty acids, and hydrocarbons.