KR101654576B1 - Nanoemulsion containing high content of hydrophobic ingredients and the method for preparing thereof - Google Patents

Abstract

The present invention relates to a nano-emulsion cosmetic composition in the form of a transparent or suspension liquid prepared by using a high-pressure emulsifier and a process for preparing the same. More particularly, To prevent the skin from becoming dry and to keep it soft and moist. BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a nano-emulsion cosmetic composition,

Skin moisturizing, nano emulsion, high pressure oil painting, TEWL

Description

TECHNICAL FIELD The present invention relates to a nano-emulsion cosmetic composition containing a high-content of an oil-soluble ingredient and a method for preparing the same,

The present invention relates to a nano-emulsion cosmetic composition in the form of a transparent or suspension liquid prepared by using a high-pressure emulsifier and a process for preparing the same. More particularly, To prevent the skin from becoming dry and to keep it soft and moist. BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a nano-emulsion cosmetic composition,

A general method of producing lotion water is to prepare an aqueous phase by dissolving a humectant, a thickening agent, etc. in purified water to form an aqueous phase, dissolving a solubilizing agent and fragrance in ethanol to prepare an ethanol phase, State liquid. However, such lotion is mainly composed of a hydrophilic moisturizing agent, and there is a limit in adjusting the balance of oil and water in the skin. Consumer dissatisfaction with the basic stickiness due to the water-soluble moisturizing agent and insufficient moisture retention still exists. In most cases, since ethanol is used as a solvent for effectively dissolving and solubilizing incompatible fragrance, solubilizing agent and small amount of oil-soluble components in water, the skin of consumers who are extremely dry or sensitive skin is rather hot It also gives a sense of excitement.

On the other hand, the interface tension between the oil-surfactant and water is extremely low, so that a nano-emulsion containing a large amount of oil-soluble ingredients can be prepared by using a phase-temperature emulsification method capable of easily producing fine emulsified particles with relatively little energy, Or how to make emulsion ( Inter . J. Cosmet . Sci . 1994 , 16 , 84-92). However, in order to prepare a stable nano emulsion through the phase-temperature emulsification method known as CAPICO method, there are restrictions on the kinds and contents of the oil-soluble and emulsifying agents to be used. Therefore, in order to calculate the optimal phase temperature range that maximizes the long-term stability, it is necessary to calculate the kind and content of the optimal emulsifier for the usable ingredient to be used by using a specially designed calculation formula. However, the type and content of emulsifiers calculated in the CAPICO method are only indicative of the starting point for carrying out the experiment, and if they can not be assisted by such CAPICO method, they must be experimentally subjected to considerable trial and error.

Accordingly, the present inventors have been studying the composition of a cosmetic composition for high-humidity nano emulsion using a high-pressure emulsification method and have a relatively high content of an oil-soluble ingredient of 4 to 12 wt%, but also have a transparent or suspended liquid- It is possible to provide a differential use experience in which the transparent or suspension liquid is converted into an opaque emulsion such that the emulsion is applied on the skin and the skin is absorbed into the skin, thus completing the present invention.

Accordingly, it is an object of the present invention to provide a nano-emulsion cosmetic composition which can enhance the function of skin barrier and prevent skin dryness and provide excellent moisturizing effect, and a method for producing the same.

In order to achieve the above object, the present invention provides a nano-emulsion cosmetic composition comprising an oil-soluble component obtained by mixing liquid and solid-phase oil-soluble components at a weight ratio of 1: 0.5 to 1.5 in an amount of 4 to 12% by weight based on the total weight of the cosmetic composition do.

The present invention also relates to a process for preparing a liquid composition, comprising the steps of: 1) mixing a liquid phase and a solid phase oil-soluble component at a weight ratio of 1: 0.5 to 1.5; And 2) introducing the mixture of 1) into a high-pressure emulsifier and repeating the emulsion at high pressure for 3 to 8 times at a pressure of 500 to 1,500 bar to prepare a nano-emulsion cosmetic.

The nano-emulsion cosmetic composition according to the present invention is produced in a transparent or suspension liquid phase containing a solid component having a high content ratio with respect to a liquid phase oil-soluble component, thereby reducing the amount of transdermal water loss and providing excellent skin moisturizing effect. The appearance of the liquid phase is converted into an opaque appearance of milky white, which is absorbed into the skin, thereby giving a distinctive feeling of use.

The present invention relates to a transparent or suspension liquid nano-emulsion cosmetic composition prepared using a high-pressure emulsifier and a process for producing the same.

The transparent or suspension liquid nano-emulsion cosmetic composition according to the present invention is prepared by mixing liquid and solid active ingredients in a weight ratio of 1: 0.5 to 1.5, wherein the total content of the liquid and solid-phase active ingredients is 4 By weight to 12% by weight. At this time, when the content of the solid phase oil-soluble component is smaller than the above-mentioned content, it is difficult to confirm that the transparent or suspension liquid is converted into a opaque milky white emulsion when applied to the skin, A problem may arise in stability over time of the emulsion.

If the total content of the oil-soluble ingredients is less than 4% by weight, sufficient oil and water balance may be broken, and if it exceeds 12% by weight, an emulsion of a completely opaque appearance having a particle size of 1 μm or more may be produced. Or it is difficult to obtain a nano emulsion of a suspended appearance.

The solid-phase oil-soluble ingredient used in the present invention is one having a melting point of 30 ° C or higher and a solid state at room temperature, and may be at least one selected from the group consisting of fats, waxes, higher alcohols, higher fatty acids and hydrocarbons. Fat, such as, for example, shea butter, mango seed butter and cacao seed butter; Waxes such as carnauba wax, candelilla wax and beeswax; Higher alcohols such as cetyl alcohol, stearyl alcohol and behenyl alcohol; Higher fatty acids such as lauric acid, myristic acid, palmitic acid and stearic acid; And hydrocarbons such as paraffin, ceresin, and microcrystalline wax. However, the present invention is not limited thereto.

Examples of the liquid phase oil-soluble component used in the present invention include at least one selected from the group consisting of oils, esters, hydrocarbons, and silicones. For example, oils such as meadowfoam seed oil, sunflower seed oil, macadamia seed oil, green tea seed oil and camellia oil; Esters such as cetyl ethyl hexanoate, octyldodecyl myristate, pentaerythritol tetraethyl hexanoate, isopropyl palmitate and isopropyl myristate; Hydrocarbons such as liquid paraffin, squalane, isohexadecane, hydrogenated polydecene, and hydrogenated polyisobutene; And silicones such as cyclomethicone, dimethicone, and phenyl trimethicone, but are not limited thereto.

The emulsion cosmetic composition according to the present invention may further contain at least one emulsifier selected from the group consisting of lecithin, a nonionic surfactant and an anionic surfactant, in addition to the above oil-soluble components. For example, lecithin such as lecithin, hydrogenated lecithin, lysore lecithin, and hydrogenate dry lecithin; 20, glyceryl isosate, polyglyceryl-3 methyl glucoside distearate, cetearyl glucoside, cetearyl glucoside, Nonionic surfactants such as inulin lauryl carbamate and polyglyceryl-10 stearate; And an anionic surfactant such as potassium cetyl phosphate, sodium stearoyl glutamate, and glyceryl stearate citrate, but the present invention is not limited thereto. The emulsifier is preferably contained in an amount of 1.5 to 3.5 wt% based on the total weight of the emulsion composition. When the emulsifier is less than 1.5 wt%, it is difficult to form a stable nano emulsion. When the emulsifier is more than 3.5 wt% .

The process for preparing a nano-emulsion cosmetic composition according to the present invention comprises the following steps:

1) mixing the liquid and solid phase oil-soluble components in a weight ratio of 1: 0.5 to 1.5; And

2) The mixture of the above 1) is put into a high-pressure emulsifier and then subjected to high-pressure emulsification treatment at a pressure of 500 to 1,500 bar for 3 to 8 times.

That is, the nano-emulsion cosmetic according to the present invention can be prepared by high-pressure emulsification treatment with high pressure emulsifier at a pressure of 500 to 1,500 bar for 3 to 8 times, preferably at a pressure of 800 to 1,200 bar for 4 to 6 times It is possible to produce a nanoemulsion having an average particle size of 50 to 200 nm by repeating high-pressure emulsification treatment. When high-pressure emulsification is carried out, the average particle size of the prepared nano-emulsion is 300 nm or more and the distribution of the particle size is very wide when the oil is subjected to repeated high-pressure emulsification under less than 3 times at a pressure of less than 500 bar. And there is no particular advantage in terms of productivity since there is no significant improvement in terms of particle size and particle size distribution when repeated high pressure emulsification exceeds 8 times with a pressure of more than 1,500 bar.

The nano-emulsion cosmetic composition according to the present invention is characterized by containing a large amount of solid-phase oil-soluble components in comparison with the liquid-phase oil-soluble component, thereby providing a transparent or suspension liquid-like appearance at the time of production, but being converted into an opaque milky opaque emulsion when applied to skin. Because of the high content of the solid component of the active ingredient, the skin barrier function is effectively enhanced during the application of the skin, thereby effectively preventing skin dryness, thereby providing a moisturizing effect that smoothes and moisturizes the skin.

Accordingly, in one embodiment of the present invention, the nano-emulsion cosmetic composition is a moisturizing cosmetic composition.

The nano-emulsion cosmetic composition according to the present invention is not particularly limited in its formulation. However, considering the appearance of the transparent or suspension liquid and advantages in use, basic cosmetics such as softening lotion, nutrition lotion, spray, mist and gel; A hair cosmetic composition such as a hair tonic, a hair essence and a hair treatment; It can be widely applied to other medicines and quasi-drugs.

Hereinafter, the present invention will be described more specifically with reference to examples and comparative examples. These embodiments are provided to understand the contents of the present invention, and the scope of the present invention is not limited to these embodiments and test examples. It is to be understood that modifications, substitutions, And this is also included in the scope of the present invention.

[Examples 1 to 4 and Comparative Examples 1 to 3]

The nano emulsion cosmetic compositions of Examples 1 to 4 and Comparative Examples 1 to 3 were prepared according to the composition shown in Table 1 below (unit: wt%).

ingredient Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Number
Prize
castle
minute Purified water Balance Balance Balance Balance Balance Balance Balance EDTA-2Na 0.02 0.02 0.02 0.02 0.02 0.02 0.02 glycerin 4.00 4.00 4.00 4.00 4.00 4.00 4.00 Butylene glycol 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Glycereth-26 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Methylglucose-20 1.00 1.00 1.00 1.00 1.00 1.00 1.00 PIGGY-75 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Trehalose 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Preservative Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount U
Prize
castle
minute Squalane 2.00 1.00 2.00 4.00 4.00 2.00 5.00 Meadow Foam Seed Oil 1.00 0.50 1.00 1.20 1.00 1.00 2.00 Dimethicone 1.00 0.50 - - 0.50 - 1.00 Sheer butter 2.00 1.00 1.00 0.80 1.50 1.00 1.00 Cetearyl alcohol 1.50 0.75 1.50 1.00 0.50 2.00 2.00 Behenyl alcohol 1.50 0.75 0.50 1.00 0.50 2.00 2.00 Potassium cetyl phosphate 0.50 0.25 0.20 0.20 0.20 0.20 0.20 Hydrogenated lecithin 0.50 0.25 1.00 1.50 1.00 1.00 1.50 Polyglycerin-10 stearate 1.00 0.50 0.70 1.00 1.00 1.00 1.00 Phage-20 glyceryl isostearate 1.00 0.50 0.50 0.50 1.00 1.00 0.80 incense Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount

<Manufacturing Method>

1) The aqueous phase components were uniformly mixed at room temperature and heated to 70 to 75 캜.

2) The oil components were uniformly dissolved and mixed by heating at 70 to 75 캜.

3) The homogenizer was used to homogeneously emulsify at 5,000 rpm for 5 minutes while the 2) was added to 1) above.

4) The above 3) was put into a high-pressure emulsifier and emulsified 5 times repeatedly under high pressure at a pressure of 1,000 bar.

5) The above 4) was cooled to room temperature and stored.

[Test Example 1] Formulation observation according to the ratio of the solid component to the oil component

It was examined whether the content ratio of the solid component of the oil-soluble component in the liquid-phase oil-soluble components of Examples 1 to 4 and Comparative Examples 1 to 3 and the resulting transparent or suspension liquid at the time of skin application were converted into an opaque milky white emulsion . In addition, the stability of the nano emulsion was confirmed by the change of the average particle size and the aging time of the emulsion immediately after the production. The results are shown in Table 2 below.

To examine the stability of the nano-emulsion with time, the nano-emulsion prepared in Examples 1 to 4 and Comparative Examples 1 to 3 was placed in a thermostatic chamber at room temperature and 45 ° C and circulated at -10 ° C to 45 ° C And stored for 1 month in a thermostatic chamber. The changes in the appearance of the nanoemulsion were observed.

Item Total content of oil-soluble ingredients
(weight%) Liquid phase: solid phase The weight ratio of the usable component Average particle size (nm) Whether the coating is changed Stability Room temperature 45 ° C cycle 1 week 4 weeks 1 week 4 weeks 3 days 1 week Example 1 9.00 1: 1.25 136 U Good Good Good Good Good Good Example 2 4.50 1: 1.25 65 U Good Good Good Good Good Good Example 3 6.00 1: 1.00 83 U Good Good Good Good Good Good Example 4 8.00 1: 0.54 107 U Good Good Good Good Good Good Comparative Example 1 8.00 1: 0.45 94 radish Good Good Good Good Good Good Comparative Example 2 8.00 1: 1.67 123 U Good Good Good detach Good detach Comparative Example 3 13.00 1: 0.62 1,172 radish detach detach detach detach detach detach

In the results of Table 2, in Examples 1 to 4, an average particle size of 60 to 140 nm was observed as a result of stability for 1 month, and when applied to skin, To one emulsion. However, in the case of Comparative Example 1, a stable suspension liquid nano-emulsion having an average particle size of 100 nm or less was prepared, but no change was observed when applied to the skin with a low solid-phase oil-soluble component content relative to the liquid- I did. In Comparative Example 2, a suspension liquid nanoemulsion having an average particle size of about 120 nm was prepared and converted into an opaque milky white emulsion when applied to skin, but the creaming phenomenon occurred within 4 weeks in a 45 ° C thermostat In particular, gelation was observed after 3 days when stored in a thermostat circulating at intervals of 12 hours from -10 ° C to 45 ° C. In the case of Comparative Example 3, the ratio of the solid-phase oil-soluble component to the oil-soluble component in the liquid phase was 0.5 or more, but the content of the total oil-soluble component was too high. Thus, the emulsion prepared immediately after the high-pressure emulsification had an average opaque appearance of about 1.3 μm It was impossible to observe changes in appearance during application to the skin.

[Example 5 and Comparative Example 4]

The nano-emulsion cosmetic compositions of Example 5 and Comparative Example 4 were prepared according to the compositions shown in Table 3 below. In Example 5 and Comparative Example 4, the total amount of the water-soluble humectant and the oiliness emollient was fixed to 16% by weight, and the nano-emulsion cosmetic preparation of Example 5 was prepared in the same manner as in Examples 1 to 4 (unit:% by weight) .

ingredient Example 5 Comparative Example 4 Number
Prize
castle
minute Purified water Balance Balance EDTA-2Na 0.02 0.02 glycerin 3.00 6.00 Butylene glycol 2.00 4.00 Glycereth-26 1.00 2.00 Methylglucose-20 1.00 2.00 PIGGY-75 - 0.50 Trehalose - 1.00 Preservative Suitable amount Suitable amount U
Prize
castle
minute ethanol - 3.00 Squalane 2.00 0.20 Meadow Foam Seed Oil 1.00 0.30 Dimethicone 1.00 - Sheer butter 2.00 - Cetearyl alcohol 1.50 - Behenyl alcohol 1.50 - Potassium cetyl phosphate 0.50 - Hydrogenated lecithin 0.50 - Phage-20 glyceryl isostearate 1.00 - PIGGY-60 Hydrogenated Castor Oil 1.00 1.0 incense Suitable amount Suitable amount

&Lt; Production method of Comparative Example 4 >

1) The aqueous phase components were uniformly mixed at room temperature and completely dissolved.

2) The oil components were uniformly mixed at room temperature and completely dissolved.

3) Using the agitator, the above 2) was slowly added to the above 1) to be solubilized to obtain a suspension liquid.

[Test Example 2] Effect of enhancing moisture of skin

In order to confirm the skin moisturizing effect of the cosmetic composition of the present invention, Example 5 and Comparative Example 4 were applied to the inner side of the upper arm twice per day for 40 days for an average of 32.8 years for one week, (TEWL) were measured at constant temperature and humidity (24 ° C, relative humidity 40%) to compare the moisture resistance. The average values of the moisture resistance were shown in Table 4 below.

&Lt; Measurement method of transepidermal water loss (TEWL)

The amount of moisture evaporating from the skin was calculated according to the area and time, and the amount of water evaporated was read and quantified with the temperature and humidity electronic sensor to measure the moisture of the skin.

1) Environmental conditions: The temperature and humidity were kept constant, and only the minimum number of persons other than the measurer and the subject were left to block the air flow as much as possible.

2) A TEWL probe was placed on the subject's measurement site. At this time, do not apply excessive force to the measurement site, place the probe lightly so as not to leave marks on the skin, and make an angle of 90 ° with the ground.

3) The TEWL value of the skin became constant as the time passed (usually 1 to 3 minutes). At this time, the grip of the probe was held as far as possible so that the body temperature of the measurer could not be transmitted.

4) The amount of water evaporated per hour per area (g / ㎡ / h) was calculated.

Item TEWL before application
(g / m 2 / hr) After application TEWL
(g / m 2 / hr) ΔTEWL
(g / m 2 / hr) Example 5 15.67 11.15 -4.52 Comparative Example 4 15.03 12.82 -2.21

From the results of Table 4, it was confirmed that the nano-emulsion cosmetic of Example 5 of the present invention significantly reduced the loss of transdermal water loss after application than the general dry skin lotion of the suspension of Comparative Example 4. Thus, it was confirmed that Example 5 according to the present invention was superior to Comparative Example 4 in improving the moisturizing effect of the skin.

Claims (9)

Wherein the oil-in-water and solid-in-oil-soluble components are mixed in a weight ratio of 1: 0.5 to 1.5, in an amount of 4 to 12% by weight based on the total weight of the emulsion composition, and no ethanol. The nanoemulsion cosmetic composition according to claim 1, wherein the liquid-phase oil-soluble ingredient is at least one selected from the group consisting of oils, esters, hydrocarbons, and silicones. The composition of claim 1, wherein the solid phase oil soluble component is selected from the group consisting of fat; Wax; One or more higher alcohols selected from the group consisting of cetyl alcohol, stearyl alcohol and behenyl alcohol; At least one higher fatty acid selected from the group consisting of lauric acid, myristic acid, palmitic acid and stearic acid; And at least one selected from the group consisting of hydrocarbons. The nanoemulsion cosmetic composition according to claim 1, wherein the nanoemulsion has a transparent or suspended liquid phase appearance. The nanoemulsion cosmetic composition according to claim 1, wherein the nanoemulsion is converted into a milky opaque emulsion upon application to the skin. 6. The nanoemulsion cosmetic composition according to any one of claims 1 to 5, wherein the composition is for skin moisturizing. 1) uniformly mixing the aqueous phase components; 2) mixing the liquid and solid oil soluble components in a weight ratio of 1: 0.5 to 1.5; 3) adding the water-soluble component of step 2) to the water-based component of step 1) and mixing them; And 4) adding the mixture obtained in 3) to a high-pressure emulsifier, and then repeating high-pressure emulsification 3 to 8 times at a pressure of 500 to 1,500 bar; &Lt; / RTI &gt; The method of claim 1, wherein the nano-emulsion cosmetic composition is a cosmetic composition. [Claim 7] The method according to claim 7, wherein the liquid-phase oil-soluble component is at least one selected from the group consisting of oils, esters, hydrocarbons, and silicones. 8. The composition of claim 7, wherein the solid phase oil soluble component is selected from the group consisting of fats; Wax; One or more higher alcohols selected from the group consisting of cetyl alcohol, stearyl alcohol and behenyl alcohol; At least one higher fatty acid selected from the group consisting of lauric acid, myristic acid, palmitic acid and stearic acid; And at least one selected from the group consisting of water, ethanol, and hydrocarbons.