KR101480702B1 - Cosmetic composition of oil in water type containing fructose 1,6-diphosphate - Google Patents

Abstract

The present invention relates to a composition for an underwater type cosmetic composition containing fructose 1,6-diphosphate, and more particularly to an underwater type composition containing fructose 1,6-diphosphate and having excellent emulsion stability and feeling.

Description

TECHNICAL FIELD The present invention relates to a composition for an underwater type cosmetic composition containing fructose 1,6-diphosphate,

The present invention relates to a composition for an underwater type cosmetic composition containing fructose 1,6-diphosphate, and more particularly to an underwater type composition containing fructose 1,6-diphosphate and having excellent emulsion stability and feeling.

Fructose 1,6-Diphosphate (FDP) protects tissues from oxidative damage such as ischemia / reperfusion or prevents damage due to ATP depletion of the extracted organs . It has been shown that such fructose 1,6-diphosphate can protect skin cells in an environment that causes oxidative damage such as ultraviolet light, such as effectively protecting tissues such as the heart in an abrupt environment such as surgical operation, In order to examine whether this effect can directly alleviate or delay the skin aging phenomenon, we conducted various experiments on skin cells as well as animals and humans, and found that fructose 1,6-diphosphate inhibited skin cell damage And the skin aging phenomenon caused thereby can be remarkably suppressed or improved.

However, fructose 1,6-diphosphate is a substance having a strong salt property with a phosphate salt in its molecular structure, and significantly decreases the thickening ability of the ionic polymer thickener and the stability of an oil-in-water type formulation, Has been severely limited.

Recently, as a method for increasing the stability of the oil-in-water-in-oil formulations containing fructose 1,6-diphosphate, a method of thickening the cosmetic composition and stabilizing emulsification by adding a high amount of wax, A method of thickening the cosmetic and stabilizing the emulsion using a cellulose-based thickening agent such as gum, hydroxyethyl cellulose and the like have been proposed.

However, any of the above-mentioned methods proposed recently has the following problems. That is, it has been known that a method of adding a high amount of wax increases the cosmetic content as a wax and has an effect of stabilizing emulsification to a certain extent. However, appearance unevenness of the cosmetic composition due to a high amount of wax, There is a disadvantage in that the feeling of use of the cosmetic material is significantly deteriorated and when the wax is oxidized, it may cause problems of change of color and discoloration, and thus it is not recognized as a method of stabilizing an oil-in-water-type formulation containing fructose 1,6-diphosphate.

In addition, the method using a cellulose-based thickener such as xanthan gum, cellulose gum, hydroxyethyl cellulose and the like can relatively stabilize the viscosity of fructose 1,6-diphosphate, thereby helping to stabilize the emulsion. However, the feeling of use of the cosmetic material is greatly lowered due to the sticky feel and gelling phenomenon unique to the cellulose-based thickener, and the cellulose-based thickening agent has a problem of significantly lowering the repellency of the cosmetic material.

Korean Patent Application No. 2006-0008134 Korean Patent Application No. 2002-0028646

Accordingly, the inventors of the present invention have conducted studies on a water-in-oil emulsion formulation capable of stably supporting fructose 1,6-diphosphate. As a result, it has been found that the stability of a cosmetic composition containing fructose 1,6-diphosphate is maintained The present inventors have found an optimum formulation condition that can be achieved and completed the present invention.

Accordingly, it is an object of the present invention to provide an underwater type composition which contains fructose 1,6-diphosphate and is excellent in emulsion stability and feeling.

In order to attain the above object, the present invention provides a composition for external application for skin, which further contains a surfactant and a thickening agent as an external composition for skin comprising a fructose 1,6-diphosphate compound as an active ingredient.

Furthermore, the present invention relates to a composition for external application for skin containing, as an active ingredient, a fructose 1,6-diphosphate compound, which comprises cetearyl glucoside / inulin lauryl carbamate or sodium stearoyl glutamate / glyceryl stearate citrate surfactant Wherein the composition further comprises polyacrylate crosspolymer-6 as a thickening agent.

The present invention can provide a composition for external application for skin stabilized with an underwater type formulation containing a fructose 1,6-diphosphate compound by setting an optimal combination of surfactants and thickeners capable of maintaining the stability of the cosmetic composition .

In addition, the stability of the emulsion inhibited by the phosphate salt of the fructose 1,6-diphosphate compound, which is an active ingredient in the composition, can increase the stability of the interface with the salt in addition to the surfactant having a strong surfactant There is provided a composition for external application for skin for anti-aging wherein the stability of the underwater type is improved by increasing the viscosity of the composition including a thickener which can improve the stability by including the surfactant therein and which is not inhibited by the salt .

The present invention provides a composition for external application for skin comprising a fructose 1,6-diphosphate compound as an active ingredient, further comprising a surfactant and a thickening agent.

Hereinafter, the present invention will be described more specifically.

Fructose 1,6-Diphosphate (FDP), which is an active ingredient of the present invention, can protect skin cells in an environment causing oxidative damage such as ultraviolet rays, and further, The aging phenomenon can be alleviated or delayed.

In other words, fructose 1,6-diphosphate has a strong antioxidative effect, and through this, fructose 1,6-diphosphate has an effect of preventing the progress of aging by offsetting free radicals etc. which cause oxidation, It alleviates the aging of the skin through the effect.

More specifically, fructose 1,6-diphosphate exhibits anti-inflammatory effects by attenuating prostaglandin E2 synthesis and COX-2 expression. It inhibits wrinkle suppression, collagen synthesis, and promotes skin elasticity, histamine secretion The skin moisturizing effect through the control of keratinocyte differentiation, and the skin vitality enhancement effect through the increase of ATP synthesis.

The fructose 1,6-diphosphate, which is an effective ingredient of the present invention, is preferably contained in an amount of 0.001 to 7.0% by weight based on the total weight of the composition. If it is less than 0.001% by weight, the antioxidative and antioxidant effects become insignificant. If it exceeds 7.0% by weight, a large amount of phosphate salt causes instability of the cosmetic formulation.

The stability of the emulsion inhibited by the phosphate salt of the fructose 1,6-diphosphate compound, which is the active ingredient in the composition for external application for skin of the present invention, is generally further improved by using the whole range of the underwater type surfactant and thickener used in cosmetics The stability can be improved. Surfactants that can be used in the present invention include, but are not limited to, FAGE-100 stearate, sorbitan stearate, sorbitan sesquioleate, FAGE-40 stearate, polysorbate 60, sucrose stearate, polyglyceryl- 3 methyl glucose distearate, cetearyl glucoside, arachidyl glucoside, C12-20 alkyl glucoside, inulin lauryl carbamate, and the like. Examples of thickeners that can be used in the present invention include cellulose gums, carbomers, hydroxyethyl cellulose, polyvinyl alcohol, phivic, xanthan gum, acrylate / C10-30 alkyl acrylate crosspolymer, sodium polyacrylate, ammonium Hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, < RTI ID = 0.0 > phage-240 / HCI < / RTI > copolymeric bis Decyltetrasil-2-ethyl, polyacrylic acid, and the like.

In particular, the stability of the emulsion inhibited by the phosphate salt of the fructose 1,6-diphosphate compound as an active ingredient in the composition for external application for skin of the present invention is not limited to the surfactant having a strong surfactant activity, It is possible to maximize the stability by adding cetearyl glucoside / inulin lauryl carbamate or sodium stearoyl glutamate / glyceryl stearate citrate as a combination of surfactants capable of increasing the viscosity It is preferable to further contain polyacrylate cross polymer-6 as an ionic thickener which is not inhibited, thereby increasing the viscosity of the composition and maximizing the stability of the underwater type emulsion formulation.

In the combination of cetearyl glucoside / inulin lauryl carbamate or sodium stearoyl glutamate / glyceryl stearate citrate surfactant among the surfactant combinations used in the present invention, cetearyl glucoside or sodium stearoyl glutamate is used as a composition It is preferable that 0.1 to 10.0% by weight, inulin lauryl carbamate or glyceryl stearate citrate, based on the total weight, is contained in an amount of 0.1 to 10.0% by weight based on the total weight of the composition. If the content is less than 0.1% by weight, the surfactant will not be exhibited. If the content is more than 10.0% by weight, the feeling on use of the cosmetic formulation and the stability of the formulation will be impaired.

The thickener of the present invention is preferably contained in an amount of 0.1 to 5.0% by weight based on the total weight of the composition. If the amount is less than 0.1% by weight, the thickening effect and the emulsification stabilizing effect are not exhibited. If the amount is more than 5.0% by weight, the productivity of the cosmetic preparation is greatly deteriorated due to the high viscosity.

The composition for external application for skin according to the present invention may comprise one or more non-toxic, pharmaceutically acceptable carriers, adjuvants, diluents or other active ingredients conventionally used in the art. The composition for external application for skin according to the present invention can be formulated by a known method using pharmaceutically acceptable carriers and excipients.

For example, the composition may be formulated in any form suitable for pharmaceutical preparations including ointments, gels, creams, patches, or external preparations such as sprays and the like. Each of these formulations may contain various kinds of bases, Additives, and the kind and amount of these components can be easily selected by the inventors.

In addition, when the composition for external application for skin according to the present invention is formulated into a cosmetic, there is no particular limitation on the form of the composition, and it is preferable to use a softener, a convergent lotion, a nutritional lotion, an eye cream, a nutrition cream, a massage cream, a cleansing cream, Cleansing water, powders, essences or packs.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail with reference to examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. Embodiments of the invention are provided to more fully describe the present invention to those skilled in the art.

[Examples 1 to 6 and Comparative Examples 1 to 12]

The cosmetic compositions (Examples 1 to 6) according to the present invention and the cosmetic compositions (Comparative Examples 1 to 12) for comparison were prepared in the following Tables 1 to 3.

Examples 1 to 6 are skin external composition compositions containing, as an active ingredient, a fructose 1,6-diphosphate compound prepared according to the present invention as cetearyl glucoside / inulin lauryl carbamate or sodium stearoyl glutamate / And a polyacrylate crosspolymer-6 as a thickener, and Comparative Examples 1 to 4 show that cosmetic compositions prepared using only one ingredient, not the combination of the above-described surfactants . Comparative Examples 5 to 6 are cosmetic compositions prepared using a combination of surfactants other than the above-mentioned surfactant combinations, and Comparative Examples 7 to 12 are non-polyacrylate crosspolymer-6 It is a cosmetic composition using other kinds of polymer thickening agents.

Category (% by weight) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Paid Cetearyl glucoside 1.50 0.50 0.30 0.00 0.00 0.00 Sodium stearoyl glutamate 0.00 0.00 0.00 2.00 2.00 1.00 Glyceryl stearate citrate 0.00 0.00 0.00 0.30 1.50 1.50 Cetearyl alcohol 0.50 0.50 0.50 0.50 0.50 0.50 Glyceryl stearate 0.50 0.50 0.50 0.50 0.50 0.50 Hydrogenated C6-14 olefin polymer 3.00 3.00 3.00 3.00 3.00 3.00 Cetyl ethyl hexanoate 3.00 3.00 3.00 3.00 3.00 3.00 Awards Inulin lauryl carbamate 0.30 0.50 1.50 0.00 0.00 0.00 Polyacrylate Crosspolymer-6 1.00 0.50 0.20 1.00 0.50 0.20 Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 glycerin 8.00 8.00 8.00 8.00 8.00 8.00 Butylene glycol 8.00 8.00 8.00 8.00 8.00 8.00 Phenoxyethanol 0.45 0.45 0.45 0.45 0.45 0.45 Purified water To 100 To 100 To 100 To 100 To 100 To 100 Active ingredient Fructose 1,6-diphosphate 0.50 0.50 0.50 0.50 0.50 0.50

Category (% by weight) Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Paid Cetearyl glucoside 1.50 0.00 0.00 0.00 0.00 0.00 Sodium stearoyl glutamate 0.00 0.00 2.00 0.00 0.00 0.00 Glyceryl stearate citrate 0.00 0.00 0.00 1.50 0.00 0.00 Cetearyl alcohol 0.50 0.50 0.50 0.50 0.50 0.50 FAGE -100 stearate 0.00 0.00 0.00 0.00 1.00 1.00 C12-20 alkyl glucoside 0.00 0.00 0.00 0.00 1.00 0.00 Polyglyceryl-3-methyl glucoside distearate 0.00 0.00 0.00 0.00 0.00 1.00 Glyceryl stearate 0.50 0.50 0.50 0.50 0.50 0.50 Hydrogenated C6-14 olefin polymer 3.00 3.00 3.00 3.00 3.00 3.00 Cetyl ethyl hexanoate 3.00 3.00 3.00 3.00 3.00 3.00 Awards Inulin lauryl carbamate 0.00 0.50 0.00 0.00 0.00 0.00 Polyacrylate Crosspolymer-6 0.50 0.50 0.50 0.50 0.50 0.50 Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 glycerin 8.00 8.00 8.00 8.00 8.00 8.00 Butylene glycol 8.00 8.00 8.00 8.00 8.00 8.00 Phenoxyethanol 0.45 0.45 0.45 0.45 0.45 0.45 Purified water To 100 To 100 To 100 To 100 To 100 To 100 Active ingredient Fructose 1,6-diphosphate 0.50 0.50 0.50 0.50 0.50 0.50

Category (% by weight) Comparative Example 7 Comparative Example 8 Comparative Example 9 Comparative Example 10 Comparative Example 11 Comparative Example 12 Paid Cetearyl glucoside 1.50 0.00 1.50 0.00 1.50 0.00 Sodium stearoyl glutamate 0.00 2.00 0.00 2.00 0.00 2.00 Glyceryl stearate citrate 0.00 1.50 0.00 1.50 0.00 1.50 Cetearyl alcohol 0.50 0.50 0.50 0.50 0.50 0.50 Glyceryl stearate 0.50 0.50 0.50 0.50 0.50 0.50 Hydrogenated C6-14 olefin polymer 3.00 3.00 3.00 3.00 3.00 3.00 Cetyl ethyl hexanoate 3.00 3.00 3.00 3.00 3.00 3.00 Awards Inulin lauryl carbamate 1.50 0.00 1.50 0.00 1.50 0.00 Carbomer 0.50 0.00 0.00 0.00 0.00 0.00 Tromethamine 0.35 0.00 0.00 0.00 0.00 0.35 Ammonium acryloyldimethyltaurate / Vpicopolymer 0.00 0.50 0.00 0.00 0.00 0.00 Hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer 0.00 0.00 0.50 0.00 0.00 0.00 Sodium polyacrylate 0.00 0.00 0.00 0.50 0.00 0.00 Polyacrylate-13 0.00 0.00 0.00 0.00 0.35 0.00 Acrylate / C10-30 alkyl acrylate crosspolymer 0.00 0.00 0.00 0.00 0.00 0.50 Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 glycerin 8.00 8.00 8.00 8.00 8.00 8.00 Butylene glycol 8.00 8.00 8.00 8.00 8.00 8.00 Phenoxyethanol 0.45 0.45 0.45 0.45 0.45 0.45 Purified water To 100 To 100 To 100 To 100 To 100 To 100 Active ingredient Fructose 1,6-diphosphate 0.50 0.50 0.50 0.50 0.50 0.50

<Manufacturing Method>

1) The oil components were weighed in a beaker and completely dissolved by heating to 75 ° C.

2) The aqueous phase components were dissolved in a separate container by heating to 70 ° C.

3) The mixture of the aqueous phase components of the above 2) was transferred to a homogenizer and the mixture was slowly added to the mixture of the oil phase components of 1) while increasing the rotation speed per minute (rpm).

4) The mixture of the above 3) was mixed for 5 minutes at 7,200 rpm, and when the temperature of the mixing phase was about 50 ° C, fructose 1,6-diphosphate was added to prepare a cosmetic.

[Test Example 1] Viscosity evaluation

The viscosities of the cosmetic compositions of Examples 1 to 6 and Comparative Examples 1 to 12 were measured and the results are shown in Table 4 below. At this time, the viscosity was measured at 2 rpm at 12 rpm on a 3-spindle using a Brookfield viscometer after leaving all the samples at 30 캜 for about 2 hours.

Viscosity (cps) Example 1 9,300 Example 2 7,200 Example 3 5,200 Example 4 8,200 Example 5 15,100 Example 6 9,200 Comparative Example 1 5,100 Comparative Example 2 3,700 Comparative Example 3 6,100 Comparative Example 4 5,300 Comparative Example 5 5,300 Comparative Example 6 6,500 Comparative Example 7 620 Comparative Example 8 1,300 Comparative Example 9 1,200  Comparative Example 10 4,500  Comparative Example 11 2,100  Comparative Example 12 650

 [Test Example 2] Measurement of emulsion stability

In order to determine the emulsification stability of the compositions of Examples 1 to 6 and Comparative Examples 1 to 12, each composition sample was placed in a 45 ° C high temperature thermostatic chamber and the time taken until separation of the water phase and oil phase of the emulsion phase was measured.

Emulsion Formulation Separation Time Example 1 More than 2 months Example 2 More than 2 months Example 3 More than 2 months Example 4 More than 2 months Example 5 More than 2 months Example 6 More than 2 months Comparative Example 1 Within 15 days Comparative Example 2 Within 5 days Comparative Example 3 Within 15 days Comparative Example 4 Within 12 days Comparative Example 5 Within 12 days Comparative Example 6 Within 15 days Comparative Example 7 Within 1 day Comparative Example 8 within 3 days Comparative Example 9 Within 2 days  Comparative Example 10 Within 5 days  Comparative Example 11 Within 2 days  Comparative Example 12 Within 1 day

As shown in Tables 4 and 5, as a composition for external application for skin containing, as an active ingredient, fructose 1,6-diphosphate compound prepared according to the present invention, cetearyl glucoside / inulin lauryl carbamate or sodium stearate Examples 1 to 6, which are cosmetic compositions comprising a combination of royle glutamate / glyceryl stearate citrate surfactant and polyacrylate crosspolymer-6 as a thickening agent, It can be confirmed that stable emulsified formulations which are not separated from each other are formed. In contrast, in the case of Comparative Examples 1 to 12, the cumulative force is remarkably lower than those of Examples 1 to 6, and the unstable formulations in which all the samples are separated within 15 days Respectively.

Claims (8)

Fructose 1,6-diphosphate;
Cetearyl glucoside / inulin lauryl carbamate or sodium stearoyl glutamate / glyceryl stearate citrate; And
Polyacrylate crosspolymer-6. The cosmetic composition according to claim 1, wherein the fructose 1,6-diphosphate is contained in an amount of 0.001 to 7.0% by weight based on the total weight of the composition. The composition of claim 1, wherein the cetearyl glucoside or sodium stearoyl glutamate is present in an amount of 0.1 to 10.0 wt% based on the total weight of the composition, the inulin lauryl carbamate or glyceryl stearate citrate is present in an amount of 0.1 to 10.0 wt% % &Lt; / RTI &gt; by weight of the cosmetic composition. The cosmetic composition according to claim 1, wherein the composition contains polyacrylate crosspolymer-6 in an amount of 0.1 to 5.0% by weight based on the total weight of the composition. The cosmetic composition according to any one of claims 1 to 4, wherein the composition is for anti-aging. The cosmetic composition according to any one of claims 1 to 4, wherein the composition is for improving skin wrinkles. The cosmetic composition according to any one of claims 1 to 4, wherein the composition is for enhancing skin elasticity. The cosmetic composition according to any one of claims 1 to 4, wherein the composition is for moisturizing the skin.