KR20150066825A - Cosmetics compositions for prevention and improvement of dandruff or itching - Google Patents

Abstract

The present invention relates to a cosmetic composition for preventing and improving dandruff or itching. The cosmetic composition for preventing and improving dandruff or itching according to the present invention contains a dandruff or itching preventing or improving component with a specific functional group enabling a covalent bond with protein residues on the surface of skin to form the covalent bond without damage to the skin, thereby providing a desired semipermanent dandruff or itching preventing and improving effect.

Description

[0001] Cosmetics compositions for prevention and improvement of dandruff or itching [

The present invention relates to a reactive dandruff or itch preventing and improving component to which a functional group binding to a protein is bound; And a cosmetic composition for preventing and improving dandruff or itch.

In general, prevention and healing of dandruff itch is to remove the itching that occurs in the skin and scalp of the human body and the dandruff which occurs in the scalp and hair to clean the body, to make it glamorous, to increase the attractiveness, to change the appearance, To spread to the body, to spread it, to use it in a similar way to others.

Related quasi-drugs are defined as not having the purpose of use such as affecting the structure and function of the body, rather than being used for the treatment or prevention of diseases, even though the action on the human body is smaller than that of the cosmetics.

In general, dandruff has dryness and oyster, dryness is due to abnormal exfoliation of the stratum corneum caused by abnormal keratinization, and oily dandruff is due to abnormality of sebum secretion. If dandruff accumulates, it is decomposed by the bacterium of the scalp, and the decomposition product stimulates the scalp and may accompany inflammation.

Causes of dandruff include erosion of epithelial cells, excessive secretion of sebum due to endocrine abnormalities, and abnormal proliferation of scalp fungi. Therefore, shampoo, rinse, hair restorer and the like for preventing excessive occurrence of dandruff are mixed together with a keratolytic agent, an anti-inflammatory agent, and a bactericide to cope with these causes. Anti-inflammatory or anti-inflammatory agents may also be added to prevent the deterioration of inflammation.

Dandruff Itching and healing compositions generally include some body iterative products such as cleansing, tidying up, protecting products for the skin and scalp, bass, points, bathing, limiting, deodorizing, depilatory, depilation and the like. Dandruff for hair and scalp Dandruff prevention and healing products include firstly dandruff for hair dandruff such as washing, treatment, regular hair, fur, hair, decolorization and prevention of itching and prevention of dandruff itching and healing products such as wool, hair growth, Products.

Typical raw materials used for preventing such dandruff itching and formulating a healing product include oily materials such as oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, and silicone oils, anionic, cationic, amphoteric and non- Antioxidants, metal ion sequestrants, colorants including dyes and pigments, fragrances, preservatives, and the like, as long as they are compatible with the present invention.

In addition, it is also possible to prevent or ameliorate dandruff or itch and to provide a moisturizing ingredient such as ceramide, glycerin, hyaluronic acid, betaine, chitosan, vitamin E (tocopherol) and urea, vasodilator, hair follicle, Anti-inflammatory and keratolytic agents such as d-panthenol, sulfur, reesin, chlorine serine, allantoin, AHA, and salicylic acid, astringents, refreshing agents, vitamins, and hormone antihistamines Fungicides, pyridoxine, and derivatives thereof, such as antibiotics, antiinflammatory agents, trichlorocarbamides, tocopherol acetate, benzophenol chelate, benzalkonium chloride, benzethonium chloride, chlorhexidine, hinothiol, phenol and isopropylmethyl phenol , Antiinflammatory agents such as glyceryl chitin acid and its derivatives, acetic acid hydrocortisone, succinic acid hydrocortisone and prednisolone, diphenylhydramine chloride, chlorophenyl maleate (Glutamate), dipotassium glycyrrhizinate (DP), phytosphingosine, vitamins, hormones, amino acids, and the like, as well as other antineoplastic agents such as glutamine, menthyl, camphor, menthol and other alanine glutamine, bisabolol, allantoin, coenzyme Q10, stearyl glycyrrhetinate , Natural drug-derived medicines, and the like.

However, when used for skin and scalp as a preventive and healing ingredient of dandruff, it is only a temporary effect until the next washing after treatment, but there is always a need to reprocess after washing.

Patent Document 1 discloses a skin non-aqueous personal care product which comprises a non-water-based functional group capable of forming a covalent bond with a protein moiety of hair or skin surface on a non-water-based part, such as carbonate, aldehyde, propionaldehyde, but are not limited to, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, (S), hydroxysuccinimidyl ester, imidazole, oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic ester, disulfide (d (wherein R is any one selected from the group consisting of alkyl, aryl, aralkyl, cyclic and unsaturated rings, and X is I, Br or Cl) selected from the group consisting of isophide, ketone and RX. Discloses a personal care product for hair or skin characterized in that it contains a conditioning component having at least one of its components and is separated into a non-aqueous part and a water-based part and is mixed immediately before use. However, (16.6 ~ 18%), skin keratin (2.3 ~ 3.8%), and skin keratin (3.1 ~ 6.9%) in the amino acids of harmful or skin constituting proteins. ) Of cysteine is targeted and reacted, so that the reaction efficiency is lowered, and each of the substances must be separately synthesized.

Korean Patent Publication No. 2008-0064467

It is an object of the present invention to provide a cosmetic composition for prevention and improvement of dandruff or itching which can continuously provide dandruff prevention or improvement effect of semi-permanent dandruff or itch without damaging the skin.

As means for solving the above-mentioned problems, the present invention relates to a carbodiimide compound; And a cosmetic composition for preventing and improving dandruff or itching comprising dandruff or itch prevention and improvement component.

As another means for solving the above problems, the present invention provides a method for preventing or improving dandruff or itching, which comprises adding to a dandruff or itching preventing and improving component a compound selected from the group consisting of carbodiimide, imidoester, aryl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, A reactive dandruff or an itch preventive and remedial component combined with a functional group covalently bonded to at least one skin surface protein selected from the group consisting of disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl and azide to provide.

As another means for solving the above-mentioned problems, the present invention provides a cosmetic composition for prevention and improvement of dandruff or itching comprising the reactive dandruff or itch prevention and improvement component.

The cosmetic composition for prevention and improvement of dandruff or itching according to the present invention contains reactive dandruff or itch prevention / improvement component and / or carbodiimide compound which incorporates specific functional groups capable of covalent bonding with protein residues of skin, It forms a covalent bond without damage and provides semi-permanent prevention and improvement of dandruff or itching wrinkles.

The present invention relates to a carbodiimide compound; And an anti-dandruff or itch preventing and improving component.

The cosmetic composition for prevention and improvement of dandruff or itching according to the present invention may be prepared by, for example, reacting a carbodiimide compound with a known dandruff or itch prevention and improvement component to prevent and / or prevent reactive dandruff or itching combined with a carbodiimide group By forming a covalent bond with the protein of the skin through the ingredients, it is possible to maximize the effect of preventing and improving dandruff or itch.

The carbodiimide compound may be used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight based on 100 parts by weight of the total composition. If the content is less than 0.001 part by weight, there is a problem that the dandruff or itching prevention and improvement effect is not continuously exhibited. On the other hand, if the content exceeds 10 parts by weight, a carbodiimide compound which exists excessively above the reaction site existing in the skin or hair There is a problem in that it can act as an ingredient to be lost without reacting with an efficacious substance in a state in which it does not react with skin, thereby failing to improve persistence.

In the present invention, the term " dandruff or itching prevention and improvement effect " refers to a function of cleansing and beautifying the body by removing itchiness that occurs in the skin and scalp and dandruff which occurs in the scalp and hair.

The dandruff or itching prevention and improvement component used in the present invention may include, but is not limited to, extracts derived from natural products such as copper, plants and minerals, amino acids, hormones, vitamins and the like. For example, hair tonic agents including moisturizing agents such as ceramide, glycerin, hyaluronic acid, betaine, chitosan, vitamin E (tocopherol) and urea, vasodilators, hair follicles, female hormones, Anti-inflammatory and keratolytic agents such as d-panthenol, sulfur, reesin, chlorheline, allantoin, AHA and salicylic acid, astringents, anti-depressants, vitamins, antihistamines, anti- Antimicrobial agents such as trichlorocarbamide, tricalcium tocopherol, ginkpyrrhion, benzalkonium chloride, benzethonium chloride, chlorhexidine, gynecol, phenol and isopropylmethylphenol, pyridoxine and derivatives thereof , Glycyrrhizic acid and derivatives thereof, antiinflammatory agents such as hydrocortisone acetate, succinic acid hydrocortisone and prednisolone, dilifying agents such as diphenhydramine, chlorophenylamine maleate, campa, menthol and the like And may be at least one selected from the group consisting of alanine glutamine, bisabolol, allantoin, coenzyme Q10, stearyl glycyrrhetinate (SG) / dipotassium glycyrrhizinate (DPG), phytosphingosine and derivatives thereof.

It is preferable that 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight or 0.1 to 5 parts by weight of the dandruff or itching prevention and improving ingredient is used with respect to 100 parts by weight of the total cosmetic composition. If the content is less than 0.001 part by weight, there is a problem of effective performance limit. If the content is more than 50 parts by weight, there is a problem in formulation and formulation stabilization.

Particularly, the dandruff or itching prevention and improvement component in the present invention can increase the reaction efficiency with the carbodiimide compound by including a carboxyl group or an amine group in the molecule.

Also, in the present invention, the dandruff or itching preventing and improving component may be one having a functional group capable of covalently bonding to the protein residues on the skin or hair surface.

The functional groups covalently bonded to the protein include carbodiimide, imidoesters, aryl azides, diazylines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, alkoxy amines, The present invention also relates to a process for the preparation of a medicament for the treatment and / or prophylaxis of a disease or condition selected from the group consisting of hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenylcarbonate, aziridine, isocyanate, thiocyanate, epoxide, May be at least one selected from the group consisting of imidazole, oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone , But is not limited thereto.

In addition, the protein may comprise reactive residues of thiol, hydroxyl, carboxyl or amine.

The carbodiimide compound is generally referred to as a compound containing a structure represented by the following formula (1) in the molecule.

[Chemical Formula 1]

-N = C = N-

The carbodiimide compound preferably has at least 1 to 1000 structures represented by the formula (1), more preferably 1 to 100 structures represented by the formula (1) It is more preferable that the structure includes 1 to 10 structures in the molecule.

In this case, if the number of the carbodiimide groups represented by the formula (1) exceeds 1,000 in one molecule, the viscosity of the starting material is too large, the molecular weight is excessively large, the reaction position where the reaction can be performed becomes excessively large, The molecule having the bodymide group becomes too large, and the efficiency is lowered by blocking the portion showing the functional effect of the molecule having the substantial function.

In the present invention, a specific example of the carbodiimide compound may be a compound represented by the following formula (2), wherein n is 4 and m is 11 in the following formula (2): benzene, 1,3, Isocyanato-1-methylethyl) -, homopolymer, polyethylene glycol mono-ether-block (benzene, 1-isocyanato- Me-ether-blocked (hereinafter referred to as polymeric carbodiimide compound of formula (2)).

(2)

In the above formula (2), n is 1 to 100 and m is 1 to 100.

Another example of the carbodiimide compound in the present invention is 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide, which is a compound represented by the following formula (3) carbodiimide or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide.HCl may be used.

(3)

In one preferred embodiment of the cosmetic composition for prevention and improvement of dandruff or itching according to the present invention, a dandruff or itching preventing and improving ingredient having a carboxyl group is made into a form of reactive ester dandruff or itch prevention and improvement component having direct bio reactivity, Reactive esterification of amino acids (ex, aspartic acid, glutamic acid) in excess of hair (17.5 ~ 21.9%) and skin keratin (15.5 ~ 23.5%) prevents dandruff or itching, including amine groups, By using a bodymide-based compound, an ester form (reactive dandruff or itch prevention and improvement component) having a reactivity can be made to increase the reaction efficiency, and the effect can be significantly increased. In addition, it is also possible to use carbodiimides, imidoesters, aryl azides, diazylines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, alkoxy The effect can be further enhanced by using dandruff or itching prevention and improvement components containing functional groups such as amines, hydrazides, haloacetyls, and azides in the molecule.

In a more preferred embodiment, a dandruff or itching preventing and improving ingredient having a carboxyl group is added to the surface of a protein molecule or a skin of the skin by first mixing the polymeric carbodiimide compound of formula (2) or 1-ethyl-3- (3- A carbodiimide compound such as 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide.HCl is firstly reacted to form a reactive ester, and dyes having an amine in the molecule in addition to the reactive ester functional group formed Or preventing and improving the itch, or reacting with the amine on the surface of the skin, it is possible to obtain an excellent dandruff or itch prevention and improvement effect. The reaction is preferably carried out at a pH of 2 to 10, more preferably at a pH of 3 to 9, most preferably at an acidic to slightly acidic pH of about 4 to 5 The reaction efficiency can be increased most. The reaction is completed within 1 minute to 30 minutes.

In the following Reaction Scheme 1, the dermatologic or itch preventive and remedial component having a carboxyl group is reacted with a carbodiimide compound first to form a reactive ester, and then reacts with an amino acid having an amine residue to form a covalent bond Respectively.

[Reaction Scheme 1]

In the following Reaction Scheme 2, asparaginic acid and glutamic acid, which are carboxylamino group-bearing biosynthetic amino acids on the surface of the skin of a skin, first react with a carbodiimide compound to form a reactive ester and then react with a dandruff or an itch prevention and improvement component having an amine residue Bond is formed.

[Reaction Scheme 2]

The carbodiimide compound improves the efficiency of the skin and hair proteins to prevent dandruff or itching and improves the reaction efficiency of the component. The reactive dandruff or the itch prevention and improvement component bound to the skin is improved in general cleaning by shampoo or soap It does not fall apart and can remain almost permanently attached to the skin.

The present invention also relates to a method for preventing or ameliorating dandruff or itching comprising adding to the dandruff or itching preventing and improving component a carbodiimide group, an imidoester, an aryl azide, a diazirine, a hydroxymethylphosphine, a pentafluorophenyl ester, a pyridyl disulfide, But are not limited to, amides, esters, amides, amides, amides, amides, amides, amides, amides, A hydroxysuccinimidyl ester, an imidazole, an oxycarbonylamidazole, an imine, a thiol, a maleimide, a vinylsulfone, an ethyleneimine, a thioether, an acrylonitrile, an acrylic acid or a methacrylic acid ester, a disulfide and a ketone Reactive dandruff combined with a functional group covalently bonded to at least one protein selected from May include an itch-preventing and improving component.

For example, as shown in Reaction Scheme 1, a carbodiimide-based compound may be firstly reacted with a carbodiimide group to form a dandruff or itch preventing and improving component. In addition, the present invention may include a cosmetic composition for preventing and improving dandruff or itch comprising the reactive dandruff or itch prevention and improvement component.

In order to further enhance the effect of the cosmetic composition for prevention and improvement of dandruff or itching according to the present invention, fatty acids such as palmitic acid and stearic acid, fatty alcohols, long-chain alkyl quaternary When mixed with a cationic surfactant such as an ammonium salt, a cationized cellulose, a cationic guar, a cationic polymer such as cationized polyvinylpyrrolidone, silicone, etc., formulation can be facilitated. In order to formulate cosmetics such as solvents, surfactants, thickeners, stabilizers, preservatives, coloring agents, pH adjusters, metal ion sequestering agents, coloring agents, pearlizing agents, external appearance improvers, pigments and powder particles, Components may be incidentally included. The ingredients for the formulation may be used in an amount of 40 to 99 parts by weight based on 100 parts by weight of the total composition.

The cosmetic composition for prevention and improvement of dandruff or itching according to the present invention can be used for the preparation of a cosmetic composition for prevention and improvement of dandruff or itching, including a component for prevention and improvement of dandruff or itching with functional group. Examples of application of the hair product include a shampoo composition, a shampoo, a rinse, a treatment, a wax, a spray, a mousse, a hair lotion, an essence, a hair cream, a permanent hair dye, a temporary hair dye, (Skin lotion, cream, essence, lotion, cream, etc.), color cosmetics (makeup base, foundation, powder, eye shadow, lip gloss) (Cleansing oil, cleansing lotion, cleansing cream, cleansing gel, pack, mask, soap, cleansing tissue, etc.), make-up for nails (manicure, nutrient, ), Sun care cosmetics, body cosmetics (body lotion, shower gel, body cream, body oil, etc.).

More preferably, the cosmetic composition for preventing or ameliorating dandruff or itching according to the present invention comprises a carbodiimide compound and at the same time contains a dandruff or itching preventing and improving component having a reactive functional group, and the above- , It is easier to maintain the activity in non-aqueous formulations, and the reaction may be carried out by mixing with a buffer for pH control just before use, or by contacting with water in a washing process. Examples of non-aqueous formulations include liquid, sheet, powder, tablet, oil, wax, ampoule, gel and the like which are used as ordinary non-aqueous cosmetic preparations. In addition, the carbodiimide compound and the anti-dandruff or itch preventive and remedial component can be formulated in encapsulated form, either as a single formulation or as a separate form of the formulation. In addition, a method of blocking a derivative having a reactive functional group through encapsulation and a dandruff or a component having a preventive and remedy function combined with moisture may be used.

In order to increase the effect of preventing and improving dandruff or itching with functional groups in the cosmetic composition for prevention and improvement of dandruff or itching according to the present invention, it is preferable to use 2-basic acid esters such as dioctyl succinate, dioctyl adipate, diethyl sebacate, Polyols, polyethylene glycol, propylene glycol, hexylene glycol, butanediol and isomers thereof, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof may be used. The above-mentioned solvents increase the permeability of the skin and are used as a solvent of a poorly soluble substance. More preferably, the solvent used for preventing dandruff or itching with a functional group and enhancing the activity-maintaining effect of the improvement component is diethyl sebacate, ethoxy glycol, bis-ethoxy glycol cyclohexane 1,4-dicarboxylate .

Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

Example  1 to 6 and Comparative Example  One

The compositions of Examples 1 to 6 and Comparative Examples 1 to 3 were prepared according to the compositions and contents shown in Table 1 below. Each of the dandruff-pruritic compositions of the present invention was applied to 10 patients each having dandruff and scalp itching. Day shampoo, and then shampooed for 10 days using a shampoo for conditioning without conditioning ingredients. Thereafter, the improvement effect on dandruff itching was compared with the sensory qualities of 5 points scale (5 excellent, 4 slightly superior, 3 no difference, 2 no effect, 1 very no effect).

division
(weight%) Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Distilled water 49.0 49.0 49.0 48.0 48.0 48.0 48.0 48.0 48.0 Hamacho Heathrow Coach 1.0 - - 1.0 - - 1.0 - - Salicylic acid - 1.0 - - 1.0 - - 1.0 - Allantoin - - 1.0 - - 1.0 - - 1.0 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride - - - 1.0 1.0 1.0 - - - Benzene, 1,3, -bis (1-isocyanato-1-methylethyl) -, homopolymers, polyethylene glycol mono-ether- - - - - - - 1.0 1.0 1.0 Buffer
(pH 4.5) 50.0 50.0 50.0 50.0 50.0 50.0 50.0 50.0 50.0 Sum 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0

Experimental results of the above Examples 1 to 6 and Comparative Examples 1 to 3 (Table 2) show that, in comparison with Comparative Examples 1 to 3 which do not contain a carbodiimide as a dandruff itch ingredient which does not substitute a bioactive reactive group, Examples 1 to 6 showed better dandruff itching improvement effects due to the covalent bond formation effect of carbodiimide, and in particular, Examples 4 to 6 using polymer carbodiimide showed better dandruff itching improving effect.

Sensory evaluation
(N = 5, respectively) Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Improvement effect
(5 points scale) 2.7 2.9 2.9 3.5 3.5 3.7 3.8 4.0 3.9

Formulation example  1: Dandruff improvement hair  Manufacture of shampoo

Dandruff improvement hair shampoo was prepared according to the ingredients and contents shown in Table 3 below in accordance with a conventional cosmetic preparation method.

Component (% by weight) Hair shampoo Polyquaternium-10 0.3 Cocamidopropyl betaine (30%) 7.0 Sodium laureth sulfate (30%) 15.0 Hamacho Heathrow Coach 0.5 Salicylic acid 0.5 Allantoin 0.5 Benzene, 1,3, -bis (1-isocyanato-1-methylethyl) -, homopolymers, polyethylene glycol mono-ether- 2.0 Carbomer 0.2 antiseptic Suitable amount Spices Suitable amount The buffer (pH 4.5) Balance Sum 100

Claims (9)

Carbodiimide compounds; And a dandruff or itching prevention and improvement component.
The method according to claim 1,
Wherein the dandruff or itching prevention and improvement component comprises a carboxyl group or an amine group in a molecule, wherein the dandruff or itching is prevented and improved.
The method according to claim 1,
The dandruff or itch prevention and remediation component may be selected from the group consisting of ceramide, glycerin, hyaluronic acid, betaine, chitosan, vitamin E (tocopherol), urea, d-panthenol, sulfur, lesionsin, , AHA, salicylic acid, trichlorocarbamide, tocopherol acetate, benzophenol chloride, benzalkonium chloride, benzethonium chloride, chlorohexidine, hinothiol, phenol, isopropylmethylphenol, pyridoxine, glycyrrhizic acid, acetic acid (Stearyl Glycyrrhetinate) / DPG (dipotassium glycyrrhizinate), phytosphingosine (DPG), pantothenic acid (PTH), and the like, Wherein the composition is at least one selected from the group consisting of phytosphingosine and derivatives thereof.
The method according to claim 1,
Wherein the dandruff or itching prevention and improvement component has a functional group capable of being covalently bonded to protein residues on skin or hair surface.
5. The method of claim 4,
The functional group covalently bonded to the protein is selected from imide ester, aryl azide, diazyline, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxy succinimide ester, alkoxyamine, hydrazide, The present invention relates to a process for the preparation of a compound of formula (I) as defined in claim 1, wherein the compound is selected from the group consisting of: haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenylcarbonate, aziridine, isocyanate, thiocyanate, epoxide, Prevention and improvement of dandruff or itching which is at least one selected from the group consisting of oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone / RTI >
The method according to claim 1,
Wherein the carbodiimide compound is 0.001 to 10 parts by weight per 100 parts by weight of the total composition, for preventing or improving dandruff or itching.
The method according to claim 1,
Carbodiimide compounds; And dandruff or itch prevention and remedy components are formulated into a single formulation in encapsulated form; Carbodiimide compounds; And a method for preventing and improving dandruff or itching which is formulated into two separate forms in which dandruff or itch prevention and improvement components are separately separated.
Dandruff or itching prevention and remediation components may be added to the prophylactic and ameliorating components of the dermatological or itchy component with at least one selected from the group consisting of carbodiimide, imidoesters, aryl azides, diazirines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, , A hydrazide, a haloacetyl, and an azide, is bonded to a functional group that is covalently bonded to the at least one protein.
9. A cosmetic composition for preventing and improving dandruff or itching comprising the active dandruff or itch prevention and improvement component according to claim 8.