KR102139148B1 - Cosmetics compositions for hair growth inhibitor - Google Patents

Abstract

The present invention relates to a cosmetic composition for inhibiting hair growth.
The cosmetic composition for inhibiting hair growth according to the present invention contains a body hair growth inhibitory component having a specific functional group capable of covalently binding to a protein residue on the body hair or the skin surface, thereby forming a covalent bond without damaging the body hair or skin to grow the desired hair semi-permanently It provides an inhibitory effect.

Description

Cosmetic composition for inhibiting hair growth {Cosmetics compositions for hair growth inhibitor}

The present invention relates to a reactive hair growth inhibiting component and a cosmetic composition for inhibiting hair growth, in which a functional group binding to a protein is bound.

In general, hair growth inhibitors are products used to inhibit the growth of body hair, and are intended to be applied to the body, scattered, or other similar methods to beautify the appearance, increase attractiveness, or change the appearance. do.

It is defined that related quasi-drugs, even if they act on the human body compared to cosmetics, have little action and do not have the purpose of use, such as not affecting the treatment or prevention of diseases, and affecting the structure and function of the body.

In general, hair and body hair are known to function to protect the body from external stimuli. However, it is now considered desirable to have no body hair, and various methods for removing body hair are used. Methods used to remove body hair include laser, ultrasonic, hair removal, tweezers, razor, electric shaver, or other mechanical methods such as plucking or cutting, and chemical methods such as hair removal cream and waxing. However, these methods have a disadvantage in that the skin is damaged or painful and the effect is not permanent, and after removing the hair, the hair must be repeated after a certain period of time.

In general, the composition for inhibiting hair growth includes some products for cleansing, trimming, and protecting the body skin, and body products such as base, point, bath, restriction, deodorization, hair removal, sun care, and suntanning.

Common raw materials used to formulate these hair growth inhibitory products include oil, raw materials such as oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, silicone oils, anions, cations, amphoterics, and nonionic surfactants. , Moisturizers, thickeners and polymer compounds used as film-forming agents, UV absorbers and blockers, antioxidants, metal ion blockers, colorants, dyes and pigments, colorants, fragrances and preservatives.

Patent Literature 1 is an active ingredient excellent in inhibiting testosterone 5α-reductase activity and extracting growth of body hair, including extract of gobon and/or Schisandra chinensis. Is disclosed.

In addition to this, the activity of testosterone 5α-reductase enzyme, which converts testosterone into a dihydrotestosterone (DHT), an active male hormone that acts to inhibit the growth of body hair, such as beard or armpit hair, as a hair growth inhibitory component Estradiol, ethinylestradiol, which has excellent inhibitory action and inhibitory effect on growth of body hair growth, and Kohamaelis extract, Arnica extract, peppermint extract, pine extract, propylene glycol Lactic acid, lactic acid salt, aloe vera gel, PCA (2-pyrrolidone-5-carboxylic acid), bisabolol, ornithined carboxylase (ODC), difluoromethylornithine (DMFO) And so on.

However, when used for the skin of the body such as armpits, arms and legs as such a hair growth inhibitory component, there is always a hassle of reprocessing after washing only providing a temporary effect until the next washing after treatment.

Korean Open Patent No. 2005-0072303

An object of the present invention is to provide a cosmetic composition for inhibiting hair growth, which is capable of continuously imparting a permanent hair growth inhibitory effect without damaging hair or skin.

As a means for solving the above problems, the present invention provides a cosmetic composition for inhibiting hair growth, comprising a carbodiimide-based compound and a hair growth inhibitory component.

As another means for solving the above problems, the present invention provides hair growth inhibitory components to carbodiimide, imidoester, aryl azide, diazirine, hydroxymethyl phosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo -Provides a reactive hair growth inhibitory component bound with a functional group covalently bonded to one or more proteins selected from the group consisting of hydroxysuccinimide esters, alkoxy amines, hydrazides, haloacetyls and azides.

As another means for solving the above problems, the present invention provides a cosmetic composition for inhibiting hair growth, comprising the reactive hair growth inhibitory component.

The cosmetic composition for inhibiting hair growth according to the present invention contains a reactive hair growth inhibitory component and/or a carbodiimide-based compound incorporating a specific functional group capable of covalently binding to a protein residue of the hair or skin, so that it is shared without damaging the hair or skin Forms a bond to provide a permanent hair growth inhibitory effect.

The present invention relates to a cosmetic composition for inhibiting hair growth, comprising a carbodiimide-based compound and a hair growth inhibitory component.

The cosmetic composition for inhibiting hair growth according to the present invention, for example, reacts a carbodiimide-based compound with a previously known body hair growth inhibiting component, undergoes a reactive hair growth inhibiting component in which a carbodiimide group is bound, and then undergoes a protein with hair or skin protein. By forming a covalent bond, the effect of inhibiting hair growth can be maximized.

The carbodiimide-based compound may be used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight based on 100 parts by weight of the total cosmetic composition. If the content thereof is less than 0.001 parts by weight, there is a problem in that it is difficult to continuously suppress hair growth, and when it exceeds 10 parts by weight, the carbodiimide-based compound that is excessively present above the reaction site present in the skin fails to react with the skin. There is a problem that it can act as a component that is not helpful in improving the persistence by reacting with an effective substance.

The term "body hair" of the present invention is a general term for all kinds of hairs that grow on the epidermis of an animal, and is also used to mean hair that grows on the scalp.

The term "inhibition effect of hair growth" of the present invention means a function of reducing the growth rate of body hair, reducing the thickness of body hair, or suppressing hair growth (hair growth) to beautify.

The hair growth inhibitory component of the present invention may be any material that inhibits hair growth, and may include extracts derived from natural products such as animals, plants, and minerals, amino acids, peptides, proteins, sugars, and vitamins, but is not limited thereto. . For example, gobon extract, omiza extract, hamelis extract, arnica extract, mint extract, pine tree extract, propylene glycol, lactic acid, lactic acid salt, aloe vera gel, PCA (2-pyrrolidone-5-carboxylic acid), It may be one or more selected from the group consisting of bisabolol, ornithinedecarboxylase (ODC) and difluoromethylornithine (DMFO).

It is preferable to use 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight based on 100 parts by weight of the total cosmetic composition. If its content is less than 0.001 part by weight, there is a problem of effective performance limit, and if it exceeds 50 parts by weight, there is a problem in formulation and formulation stabilization.

In particular, the hair growth inhibitory component in the present invention can increase the reaction efficiency with a carbodiimide-based compound by including a carboxyl group or an amine group in the molecule.

In addition, in the present invention, the hair growth inhibitory component may have a functional group capable of covalent bonding with a protein residue on the body hair or the skin surface.

Functional groups that covalently bond with the protein include carbodiimide, imidoester, arylazide, diazirine, hydroxymethyl phosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxy amine, Hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxysuccinimidyl ester , Imidazole, oxycarbonyl amidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone. , But is not limited to this.

In addition, the protein may include reactive residues of thiol, hydroxyl, carboxyl, or amine.

The carbodiimide-based compound collectively refers to a compound containing a structure represented by Formula 1 in the molecule.

[Formula 1]

-N=C=N-

The carbodiimide-based compound preferably contains about 1 to 1000 structures of Formula 1, more preferably 1 to 100 structures in the molecule represented by Formula 1, and represented by Formula 1 It is more preferable to include 1 to 10 structures in the molecule.

In this case, when the number of carbodiimide groups represented by Formula 1 exceeds 1000 in one molecule, the viscosity of the raw material is too large, the molecular weight is excessively large, and the reaction sites that can react are excessively large. A molecule having a bodyimide group becomes so large that a problem occurs in that efficiency is lowered by masking a portion showing a functional effect of a molecule having a substantial function.

Specific examples of the carbodiimide-based compound in the present invention may be a compound represented by the following Chemical Formula 2:

[Formula 2]

In Formula 2, n is 1 to 100, m is 1 to 100.

More preferred examples of the carbodiimide-based compound are compounds in which n is 4 and m is 11 in Chemical Formula 2, benzene, 1,3,-bis(1-isocyanato-1-methylethyl)-, Homopolymer, polyethylene glycol mono-me-ether-blocked (Benzene, 1,3-bis(1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked) Polymer form carbodiimide compound).

As another example of the carbodiimide-based compound in the present invention, as a compound represented by the following formula (3), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (1-Ethyl-3-(3-dimethylaminopropyl) )carbodiimide) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.HCl (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide.HCl).

[Formula 3]

In a preferred embodiment of the cosmetic composition for inhibiting hair growth according to the present invention, a hair growth inhibitory component having a carboxyl group is made into a reactive ester body hair growth inhibitory component having direct bioreactivity, or body hair (17.5-21.9%) and skin keratin Reactive esterification of amino acids (ex, aspartic acid, glutamic acid) present in excess in (15.5-23.5%) by using a carbodiimide-based compound that can be targeted by a hair growth inhibitory component containing an amine group to target By making a reactive hair growth inhibitory component) to increase the reaction efficiency, the effect can be significantly increased. In addition, carbodiimide, imidoester, arylazide, diazirine, hydroxymethyl phosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxy, which can target other amino acids The effect can be further enhanced by using a body hair growth inhibitory component containing a functional group such as amine, hydrazide, haloacetyl, and azide in the molecule.

In a more preferred embodiment, the hair growth inhibitory component molecule having a carboxyl group, or a polymer carbodiimide-based compound of Formula 2 or 1-ethyl-3-(3-dimethylaminopropyl)car on the surface of the protein of skin or body hair Carbodiimide-based compounds such as bodyimide and hydrochloric acid (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.HCl) are first reacted to form reactive esters, and body hair having amines in the reactive groups of the formed reactive esters again An excellent effect for inhibiting hair growth can be obtained by reacting a growth inhibitory component or by reacting with amines on the skin or on the skin surface. In the reaction, it is possible to react under conditions of pH 2 to 10, more preferably, it is preferable to react at pH 3 to 9, and most preferably, it reacts on an acidic to slightly acidic aqueous solution of pH 4 to 5 or so. The most reaction efficiency can be increased. The reaction is complete within 1 to 30 minutes.

In Reaction Scheme 1 below, a schematic diagram of a reaction in which an active ingredient having a carboxyl group (a body hair growth inhibitory component) reacts first with a carbodiimide-based compound to form a reactive ester, and then reacts with an amino acid in a living body having an amine residue to form a covalent bond. Showed.

[Scheme 1]

In Reaction Scheme 2, aspartic acid and glutamic acid, biological amino acids having a carboxyl group on the surface of the skin (or body hair) protein, react first with a carbodiimide-based compound to form a reactive ester, followed by reaction with a body hair growth inhibitory component having an amine residue to share The reaction schematic for forming a bond is shown.

[Scheme 2]

The carbodiimide-based compound increases the reaction efficiency between the hair or skin protein and the hair growth inhibitory component, so that the reactive hair growth inhibitory component bound to the hair or skin does not come off well during normal cleaning due to shampoo or soap, and is hardly removed. It can be permanently attached to body hair or skin.

The present invention also provides carbodiimide groups, imidoesters, arylazides, diazirines, hydroxymethyl phosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters to the hair growth prevention component, Alkoxy amine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxysuccinim Selected from the group consisting of imidyl ester, imidazole, oxycarbonyl amidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid ester, methacrylic acid ester, disulfide and ketone It may include a reactive hair growth inhibitory component coupled to a functional group covalently bound to one or more proteins.

For example, as shown in Reaction Scheme 1, the carbodiimide-based compound may include a body hair growth inhibitory component bound by a carbodiimide group produced by primary reaction. In addition, the present invention may include a cosmetic composition for inhibiting hair growth, comprising the reactive hair growth inhibitory component.

Fatty acids such as palmitic acid and stearic acid, fatty alcohols, straight chain and branched chain long-chain alkyl quaternary ammonium salts, etc. in order to additionally increase the effect in the cosmetic composition for inhibiting hair growth according to the present invention Formulation can be facilitated by mixing with cationic polymers such as cationic surfactant, cationic cellulose, cationic guar, and cationic polyvinylpyrrolidone, silicone, and the like. In addition, for formulation into cosmetic preparations, for the formulation of cosmetics such as solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH adjusting agents, metal ion blockers, colorants, pearling agents, appearance improvers, pigments, powder particles, etc. Ingredients may be included incidentally. Ingredients for the formulation may be used from 40 to 99 parts by weight based on 100 parts by weight of the total composition.

The cosmetic composition for inhibiting hair growth according to the present invention may be used in the formulation of a cosmetic composition for inhibiting hair growth by including a component having a functional group for inhibiting hair growth. Examples of application of skin products are generally skin care, basic cosmetics for protection (cosmetics, serum, essence, lotion, cream, etc.), color cosmetics (make-up base, foundation, powder, eye shadow, lip gloss, lipstick, lip balm, etc.) , Cleaning cosmetics (foam cleaning, cleansing oil, cleansing lotion, cleansing cream, cleansing gel, pack, mask, soap, cleansing tissue, etc.), sun care cosmetics, hair removal cosmetics (shaving products, hair removal agents, after shaving products), Body cosmetics (body lotion, shower gel, bath, body cream, body oil, etc.) can all be included, and even for hair, shampoo, conditioner, treatment, hair pack, hair essence, wax, gel, spray, etc. All formulations may be included.

More preferably, the cosmetic composition for inhibiting hair growth according to the present invention includes a carbodiimide-based compound and a body hair growth-inhibiting component having a reactive functional group at the same time. It is easier to maintain its activity in the formulation, and it can be mixed with a buffer for pH adjustment immediately before use, or a reaction can be made by contacting with water in the washing process. Examples of non-aqueous formulations include liquid, sheet, powder-powdered, tablet, oil, wax, ampoules, gels, and the like used as conventional non-aqueous cosmetic preparations. In addition, the carbodiimide-based compound and the hair growth inhibitory component may be formulated as a single agent in an encapsulated form or two agents in a separate form. In addition, a method of blocking a derivative of a form in which a functional group having reactivity and a component having an inhibitory function for hair growth is combined through encapsulation can also be used.

In order to increase the effect of inhibiting hair growth having a functional group in the cosmetic composition for inhibiting hair growth, according to the present invention, 2-basic acid ester oils such as dioctyl succinate, dioctyl adipate, diethyl sebacate, polyol, and polyethylene glycol , Propylene glycol, hexylene glycol, butanediol and isomers thereof, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof. The above-mentioned solvent increases the permeability of body hair or skin and is used as a solvent for poorly soluble substances. More preferably, the solvent used to increase the activity retention effect of the hair growth inhibitory component having a functional group includes diethyl sebacate, ethoxy glycol, bis-ethoxy glycol cyclohexane 1,4-dicarboxylate, and the like.

Hereinafter, the present invention will be described in detail by examples. However, the following examples are only to illustrate the present invention, the content of the present invention is not limited to the following examples.

Example 1 to 4 and Comparative example 1 to 2

The compositions for inhibiting hair growth of Examples 1 to 4 and Comparative Examples 1 to 2 were prepared with the compositions and contents shown in Table 1 below, and the prepared compositions were evaluated to each of 15 subjects who felt the need for hair removal for each composition. Apply evenly to the armpits with body hair and incubate for 30 minutes at room temperature to induce the reaction and repeat the process of first washing with running water and shampoo once every day for 5 days, then after 5 days, 5 point scale (5 Very good, 4 slightly good, 3 no difference, 2 no effect, 1 very no effect) sensory results and average body hair thickness and length change within the unit area were measured to compare the hair growth inhibition effect.

Classification (% by weight) Comparative Example 1 Comparative Example 2 Example 1 Example 2 Example 3 Example 4 Distilled water 49.0 49.0 48.0 48.0 48.0 48.0 2-pyrrolidone-5-carboxylic acid (PCA) 1.0 - 1.0 - 1.0 - Difluoryl methyl ornithine (DFMO) - 1.0 - 1.0 - 1.0 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.hydrochloric acid - - 1.0 1.0 - - Benzene, 1,3,-bis(1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-me-ether-block - - - - 1.0 1.0 Buffer (pH 4.5) 50.0 50.0 50.0 50.0 50.0 50.0 Sum 100.0 100.0 100.0 100.0 100.0 100.0

The sensory evaluation results of Tables 1 to 4 and Comparative Examples 1 to 2 (Table 2) showed that carbodiimide was compared to Comparative Examples 1 and 2, which did not contain carbodiimide as a body hair growth inhibitory component in which the bioreactive group was not substituted. Examples 1 to 4 included exhibited a better hair growth inhibition effect due to the covalent bond formation effect of carbodiimide, and in particular, Examples 3 to 4 using polymer carbodiimide showed better hair growth inhibition effect than Examples 1 to 2 It was shown.

Sensory evaluation
(Each n=5) Comparative Example 1 Comparative Example 2 Example 1 Example 2 Example 3 Example 4 Improvement effect
(5 point scale) 1.7 2.1 3.2 3.4 3.8 4.0

The average body hair thickness and length change in Examples 1 to 4 and Comparative Examples 1 and 2 were compared with the average body hair thickness in the unit area (2 cm×2 cm) before treatment of the evaluation subjects, and the average change in body hair thickness after treatment, and the unit area before treatment ( 2cm×2cm) The average change in body hair thickness after treatment compared to the average body hair length in Table 3 (Table 3), compared to Comparative Examples 1 to 2, which did not contain carbodiimide as a body hair growth inhibitory component without bioreactive groups substituted. Examples 1 to 4 including mead showed better hair growth inhibition effect (reduction in thickness and length) as a covalent bond forming effect of carbodiimide, and in particular, 3 to 4 in Example 1 using polymer carbodiimide It showed better hair growth inhibition effect (reduction in thickness and length) than ~2.

Average change per unit area Comparative Example 1 Comparative Example 2 Example 1 Example 2 Example 3 Example 4 Thickness change (mm) -0.005 -0.007 -0.011 -0.013 -0.022 -0.024 Length change (mm) -0.05 -0.052 -0.74 -0.81 -0.98 -1.1

Claims (9)

A carbodiimide-based compound represented by Formula 2 below; And a hair growth inhibitory component having a functional group capable of covalently binding to a protein residue on the skin or skin surface.
[Formula 2]

In Formula 2, n is 1 to 100, m is 1 to 100.
According to claim 1,
The body hair growth inhibiting component is a cosmetic composition for inhibiting hair growth, comprising a carboxyl group or an amine group in the molecule.
According to claim 1,
The body hair growth inhibitory ingredients include gobon extract, omiza extract, hamelis extract, arnica extract, mint extract, lumber extract, propylene glycol, lactic acid, lactic acid salt, aloe vera gel, PCA (2-pyrrolidone-5-carboxylic acid ), bisabolol, ornithine decarboxylase (ODC) and difluoromethyl ornithine (DMFO) at least one selected from the group consisting of a cosmetic composition for inhibiting hair growth.
delete According to claim 1,
The functional group covalently binding to the protein is imido ester, aryl azide, diazirine, hydroxymethyl phosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxy amine, hydrazide, Haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxysuccinimidyl ester, imidazole, Oxycarbonyl amidazole, imine, thiol, maleimide, vinyl sulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone cosmetic composition for inhibiting hair growth .
According to claim 1,
The carbodiimide-based compound is 0.001 to 10 parts by weight based on 100 parts by weight of the total composition.
According to claim 1,
Carbodiimide-based compounds and hair growth inhibitory components are formulated into a single agent in encapsulated form; A carbodiimide-based compound and a body hair growth inhibiting cosmetic composition for inhibiting hair growth are formulated in two separate formulations.
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