JPH09315949A - Irritation-protecting agent and cosmetic containing the same used for protecting irritation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an irritation-protecting agent effective for the protection of skins, hairs and mails, and future to obtain a cosmetic for protection irrita tion, containing the same. SOLUTION: This irritation-protecting agent comprises the polymer or copolymer of one or more kinds of compounds selected from compounds of the formula [R1 is H, a 1-4C alkyl; R2 is a primary to tertiary 1-4C alkylamine, a quitrent 1-4C alkylammonium ion; (m), (n) are each 1-4]. The polymer includes the polymer of mechacryloyloxyethylphosphorylchlokine. The irritation-protecting agent can be added in an amount of 0.001-20wt.% to irritation-protecting cosmetics for skins, hairs, cleansing agents, beautiful nails and make-up, bath agents, etc. The cosmetic is excellent in an action on the protection of irritation originated from irritative substances.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a stimulant-protecting agent useful for protecting skin, hair and nails and a stimulant-protecting cosmetic containing the same.

[0002]

2. Description of the Related Art The deterioration of the environment in recent years is exerting various adverse effects on the human body which could not be imagined in conventional social life. For example, depletion of the ozone layer increases the transmission of ultraviolet light, promotes the development of skin cancer,
Pollen such as cedar, which has increased due to changes in vegetation and by-products of production activities such as OX and SOX, as well as mites and dust, which are one of the causes of increased human living space, are skin irritation and damage. It is also said to be a cause or trigger of excessive biological defense reactions such as atopic dermatitis. In addition, it has been reported that these ultraviolet rays and chemical substances have an adverse effect not only on the skin but also on the hair, and the occurrence of cut hair and split ends has increased in recent years. In response to such environmental changes, various ultraviolet protective cosmetics have been developed and dealt with with respect to ultraviolet rays by developing ultraviolet absorbers and the like, but the above irritants have been impaired by inflammation and disorders. There were only countermeasures to the extent that skin functions were complemented by moisturizers and the like. That is, the stimulation by such a stimulant is prevented by preventing the intrusion of the stimulus and the manifestation of the inflammatory effect.
There was a need for a means to suppress it.

On the other hand, although one or more polymers or copolymers selected from the compounds represented by the general formula (I) have been known to have a skin-protecting action due to a remarkable water-retaining action, The effect of suppressing the irritation derived from the stimulant was not known at all.

[0004]

SUMMARY OF THE INVENTION The present invention has been made under such circumstances, and it is an object of the present invention to provide means for suppressing a stimulus derived from a stimulating substance.

[0005]

In view of such a situation,
The present inventors have found that the skin,
As a result of repeated research for substances capable of protecting each part of the living body such as hair and nails, one or more polymers or copolymers selected from the compounds represented by the general formula (I) They found such a function and completed the invention. Hereinafter, the present invention will be described in detail.

[0006]

Embedded image General formula (I) (however, R1 represents a hydrogen atom or a C1-C4 alkyl group, R2 is a primary, secondary, tertiary C1-C4 alkylamine or quaternary C1). Represents an alkylammonium ion of 4 and m and n each independently represent an integer of 1 to 4.)

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION

(1) Irritation protectant of the present invention The irritation protector of the present invention is composed of one or more polymers or copolymers selected from the compounds represented by the general formula (I). In the compound represented by the general formula (I),
In the formula, R1 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and R1 is preferably a hydrogen atom and a methyl group,
More preferably, it is a methyl group. Also, R2 is grade 1, 2
Represents a primary or tertiary alkylamine having 1 to 4 carbon atoms or a quaternary alkylammonium having 1 to 4 carbon atoms.
Preferred examples of 2 include a methylamino group, a dimethylamino group, a trimethylammonium group and a triethylammonium group, and a trimethylammonium group is more preferred. Further, m and n each independently represent an integer of 1 to 4, but 2 is preferable for both. Any of these compounds can be produced by a known method. For example, it can be obtained by reacting bromoalkylphosphoryl dichloride, hydroxyalkylphosphoryl dichloride and hydroxyalkylalkyl acrylate to obtain alkylacryloyloxyalkyl bromoalkylphosphoric acid, which is further reacted with amines in methanol. The thus obtained compound represented by the general formula (I) can be obtained as the irritation protector of the present invention by using an alcohol or the like as a solvent and adding a polymerization initiator such as azobisisobutyronitrile for polymerization. . At this time, the degree of polymerization is not particularly limited, but preferably has an average molecular weight of 3,000 or more, more preferably 5,000 or more, and further preferably 10,000 or more, which can preferably exhibit a stimulating protection effect. Most preferred as the irritation protector of the present invention is a polymer of methacryloyloxyethylphosphorylcholine (Compound 1) (hereinafter abbreviated as PMPC).

[0008]

Embedded image

(2) Cosmetic Material for Irritation Protection of the Present Invention The cosmetic material for irritation protection of the present invention is characterized by containing the above-mentioned irritation protection agent. The preferred content of the stimulant protective agent in the stimulant protective cosmetic of the present invention is 0.001 to 0.001.
It is 20% by weight, more preferably 0.01 to 15% by weight, and still more preferably 0.05 to 10% by weight. Examples of the stimulant protection cosmetics of the present invention include creams, emulsions, skin cosmetics such as lotions, hair tonics, hair creams, hair cosmetics such as rinses, shampoos, soaps and other cleansing agents, nail colors and the like. Examples include make-up cosmetics such as beautiful nail cosmetics, foundations, eye colors, cheek colors, and lip colors, and bath agents such as bath bubbles. The stimulant protective agent of the present invention protects the skin from irritating substances in skin cosmetics, makeup cosmetics, cleansing agents and bath preparations, and protects hair from irritating substances in hair cosmetics and cleaning agents. It can protect and protect nails from nitro compounds, which are said to cause yellowing in beauty nail cosmetics. In the cosmetic of the present invention, is an essential component,
In addition to the stimulant protective agent, it is possible to contain an optional component usually used in cosmetics. Such optional components include:
For example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, and fatty acids such as stearic acid and oleic acid. , Glycerin or 1,3
Polyhydric alcohols such as butanediol, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, ethanol, thickeners such as carbopol,
Examples include preservatives, ultraviolet absorbers, antioxidants, pigments, powders, and the like. The cosmetic of the present invention thus obtained has an excellent action of suppressing irritation caused by irritants such as chemical substances, mites, dust, and pollen.

[0010]

【Example】

<Examples 1 to 4> Lotions were prepared according to the formulations shown in Table 1 below. That is, the ingredients were stirred at 80 ° C. to solubilize and cool to obtain a lotion. Hereinafter, the numerical values of the prescription indicate parts by weight.

[0011]

[Table 1]

<Examples 5 to 8> Lotions were prepared according to the formulations shown in Table 2 below. That is, the ingredients were stirred at 80 ° C. to solubilize and cool to obtain a lotion.

[0013]

[Table 2]

<Examples 9 to 12> Creams were prepared according to the formulations shown in Table 3 below. That is, a, b, and c were each heated to 80 ° C, kneaded with b, diluted with b, gradually added with c, emulsified, stirred and cooled to obtain a cream.

[0015]

[Table 3]

<Example 13> A foundation was prepared according to the following formulation. That is, a, b, and c were each heated and dissolved at 80 ° C, kneaded well with b, diluted with b, dispersed in d, gradually added with c, emulsified, and stirred and cooled. Got a foundation. B PMPC (Molecular weight 12,000) 1 Maltitol 70% Aq 10 Glyceryl monooleate 5 Methylparaben 0.3 B Liquid paraffin 15 Microcrystalline wax 5 Ha water 42.7 Nitalc 7 Titanium oxide 10 Yellow iron oxide 3 Bengala 1

<Example 14> A shampoo was prepared according to the following formulation. That is, the prescription components were dissolved by heating and cooled to obtain a shampoo. Palm oil fatty acid diethanolamide 10 POE (20) sodium lauryl sulfate 10 1,3-butanediol 5 PMPC (molecular weight 6800) 1 water 74

Example 15 A hair tonic was prepared according to the following formulation. That is, the formulation components were heated and dissolved, and then stirred and cooled to obtain a hair tonic. 1-menthol 0.1 ethinyl estradiol 0.1 capsicum tincture 0.1 PMPC (molecular weight 12,000) 0.1 1,3-butanediol 5 ethanol 45 water 49.6

Example 16 A bath agent was prepared according to the following formulation. That is, the prescription components were kneaded with a kneader and divided to obtain a bath agent. Sodium carbonate 40 Sodium sulfate 50 PMPC (Molecular weight 6800) 10

<Example 17> For the cosmetics of Examples 1 to 12, 1 group of ICR mice (male, weight: 20 to 3)
0g) was used to examine the stimulus-protective effect. That is,
The back was shaved, 0.05 ml of cosmetic was administered, and 0.05 ml of a 1% aqueous solution of sodium lauryl sulfate was subjected to closed patching for 24 hours. This operation was repeated four times, and the scale, erythema, and conductance of the skin were measured 72 hours after the last patch was removed. Scale and erythema are very strong 2
The score was given as 1 point for the point and the clear, and 0.5 point for the weak.
The conductance (μΩ ^-1 ) was measured by a corneometer. Table 4 shows the average score and conductance. As Control 1, the PMPC of Example 1 was replaced with water, as Control 2, the PMPC of Example 9 was replaced with water, and as Comparative Example 1, the PMPC of Example 1 was used.
Which has a similar chemical structure and is known to have a conventional skin protecting function such as a moisturizing effect is replaced with lecithin, and as Comparative Example 2, PMPC of Example 9 is also replaced with lecithin. I used one. It can be seen that the stimulus-protecting agent of the present invention is excellent in protecting the living body from stimulus of stimulating substances. This effect does not stem only from preventing contact with or invasion of stimulants by interfering with physical contact, that is, the fact that the stimulant protective agent of the present invention suppresses stimulus expression itself means that It is clear from the comparison with Comparative Examples 1 and 2.

[0021]

[Table 4]

[0022]

According to the present invention, it is possible to provide a means for suppressing the irritation caused by a stimulating substance.

Embedded image

Embedded image

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display location A61K 7/075 A61K 7/075 7/50 7/50 C08F 30/02 MNS C08F 30/02 MNS C08L 43/02 LKA C08L 43/02 LKA

Claims (9)

[Claims] 1. A stimulation protector comprising one or more polymers or copolymers selected from the compounds represented by formula (I). Embedded image General formula (I) (however, R1 represents a hydrogen atom or a C1-C4 alkyl group, R2 is a primary, secondary, tertiary C1-C4 alkylamine or quaternary C1). Represents an alkylammonium ion of 4 and m and n each independently represent an integer of 1 to 4.) 2. A compound represented by the general formula (I) is methacryloyloxyethylphosphorylcholine (compound 1).
The irritation-protective agent according to claim 1, which comprises the polymer, polymethacryloyloxyethylphosphorylcholine. Embedded image 3. A stimulant-preventing cosmetic containing the stimulant-protecting agent according to claim 1 or 2. 4. The cosmetic according to claim 3, wherein the content of the irritation-protective agent according to claim 1 or 2 is 0.001 to 20% by weight. 5. The cosmetic according to claim 3, wherein the use is for skin protection, hair protection or nail protection. 6. A cosmetic material for irritation protection, containing one or more polymers or copolymers selected from the compounds represented by the general formula (I). 7. The cosmetic composition for preventing irritation according to claim 6, comprising the polymer polymethacryloyloxyethylphosphorylcholine, wherein the compound represented by the general formula (I) is methacryloyloxyethylphosphorylcholine (compound 1). 8. The content of one or more polymers or copolymers selected from the compounds represented by the general formula (I) is 0.001 to 20% by weight. Or 7
The cosmetic described. 9. The cosmetic according to claim 6, wherein the use is skin protection, hair protection or nail protection.