JPH1017430A - Irritation-preventing agent, and cosmetic containing the same for preventing irritation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a irritation-preventing agent for suppressing an irritation derived from irritating substances, useful for protecting of a skin, hair and nails by containing a specific compound having remarkable water retention as an effective component. SOLUTION: This agent contains trehalose or its derivative as an effective component. Sulfated trehalose or acylated trehalose is esp. suitable as trehalose derivatives. The objective cosmetic for preventing irritation contains preferably 0.001-20wt.%, esp. preferably 0.05-10wt.% of the irritation-preventing agent. Creams, cosmetic water, hair tonics, shampoos, nail colors, foundations, bath bubbles, etc., are exemplified as the cosmetic for preventing irritation.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a stimulant-protecting agent useful for protecting skin, hair and nails and a stimulant-protecting cosmetic containing the same.

[0002]

2. Description of the Related Art The deterioration of the environment in recent years is exerting various adverse effects on the human body which could not be imagined in conventional social life. For example, depletion of the ozone layer increases the transmission of ultraviolet light, promotes the development of skin cancer,
Pollen such as cedar, which has increased due to changes in vegetation and by-products of production activities such as OX and SOX, as well as mites and dust, which are one of the causes of increased human living space, are skin irritation and damage. It is also said to be a cause or trigger of excessive biological defense reactions such as atopic dermatitis. In addition, it has been reported that these ultraviolet rays and chemical substances have an adverse effect not only on the skin but also on the hair, and the occurrence of cut hair and split ends has increased in recent years. In response to such environmental changes, various ultraviolet protective cosmetics have been developed and dealt with with respect to ultraviolet rays by developing ultraviolet absorbers and the like, but the above irritants have been impaired by inflammation and disorders. There were only countermeasures to the extent that skin functions were complemented by moisturizers and the like. That is, the stimulation by such a stimulant is prevented by preventing the intrusion of the stimulus and the manifestation of the inflammatory effect.
There was a need for a means to suppress it.

On the other hand, one or more selected from trehalose or a derivative thereof has been known to have a skin-protecting action due to a remarkable water-retaining action, but has no known action to suppress irritation caused by irritants. Had not been.

[0004]

SUMMARY OF THE INVENTION The present invention has been made under such circumstances, and it is an object of the present invention to provide means for suppressing a stimulus derived from a stimulating substance.

[0005]

In view of such a situation,
The present inventors have found that the skin,
As a result of repeated studies on substances capable of protecting various parts of the living body such as hair and nails, one or more kinds of trehalose or its derivatives were found to have such an effect, and the invention was completed. Hereinafter, the present invention will be described in detail.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION

(1) The stimulus-protecting agent of the present invention The stimulating-protective agent of the present invention comprises the above trehalose or a derivative thereof. Trehalose has been found in resurrected grasses and is already known to have significant water retention. It is already commercially available. Examples of the derivatives include sulfated trehalose in which a hydroxyl group is sulfated, acylated acylated trehalose, and alkylated alkylated trehalose, which are derivatized according to a conventional method. Also, these are already commercially available and easily available. Of these, sulfated trehalose is most preferred. Of course, the physiologically acceptable salts thereof are also included in the stimulus-protecting agent of the present invention. Physiologically acceptable salts include alkali metal salts such as sodium and potassium, alkaline earth metals such as calcium and magnesium, ammonium salts, organic amine salts such as triethylamine and triethanolamine, and basic salts such as lysine and arginine. Examples include amino acid salts and the like.

(2) Cosmetic for irritation protection of the present invention The cosmetic for irritation protection of the present invention is characterized by containing the above-mentioned irritation protective agent. The preferred content of the stimulant protective agent in the stimulant protective cosmetic of the present invention is 0.001 to 0.001.
It is 20% by weight, more preferably 0.01 to 15% by weight, and still more preferably 0.05 to 10% by weight. Examples of the stimulant protection cosmetics of the present invention include creams, emulsions, skin cosmetics such as lotions, hair tonics, hair creams, hair cosmetics such as rinses, shampoos, soaps and other cleansing agents, nail colors and the like. Examples include make-up cosmetics such as beautiful nail cosmetics, foundations, eye colors, cheek colors, and lip colors, and bath agents such as bath bubbles. The stimulant protective agent of the present invention protects the skin from irritating substances in skin cosmetics, makeup cosmetics, cleansing agents and bath preparations, and protects hair from irritating substances in hair cosmetics and cleaning agents. It can protect and protect nails from nitro compounds, which are said to cause yellowing in beauty nail cosmetics. In the cosmetic of the present invention, is an essential component,
In addition to the stimulant protective agent, it is possible to contain an optional component usually used in cosmetics. Such optional components include:
For example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, and fatty acids such as stearic acid and oleic acid. , Glycerin or 1,3
Polyhydric alcohols such as butanediol, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, ethanol, thickeners such as carbopol,
Examples include preservatives, ultraviolet absorbers, antioxidants, pigments, powders, and the like. The cosmetic of the present invention thus obtained has an excellent action of suppressing irritation caused by irritants such as chemical substances, mites, dust, and pollen.

[0008]

【Example】

<Examples 1 to 4> Lotions were prepared according to the formulations shown in Table 1 below. That is, the ingredients were stirred at 80 ° C. to solubilize and cool to obtain a lotion. Hereinafter, the numerical values of the prescription indicate parts by weight.

[0009]

[Table 1]

<Examples 5 to 8> Lotions were prepared according to the formulations shown in Table 2 below. That is, the ingredients were stirred at 80 ° C. to solubilize and cool to obtain a lotion.

[0011]

[Table 2]

<Examples 9 to 12> Creams were prepared according to the formulations shown in Table 3 below. That is, a, b, and c were each heated to 80 ° C, kneaded with b, diluted with b, gradually added with c, emulsified, stirred and cooled to obtain a cream.

[0013]

[Table 3]

Example 13 A foundation was prepared according to the following formulation. That is, a, b, and c were each heated and dissolved at 80 ° C, kneaded well with b, diluted with b, dispersed in d, gradually added with c, emulsified, and stirred and cooled. Got a foundation. B Sulfated trehalose Na 1 Maltitol 70% Aq 10 Diglyceryl monooleate 5 Methyl paraben 0.3 B Liquid paraffin 15 Microcrystalline wax 5 C Water 42.7 Nitarc 7 Titanium oxide 10 Yellow iron oxide 3 Bengala 1

Example 14 A shampoo was prepared according to the following formulation. That is, the prescription components were dissolved by heating and cooled to obtain a shampoo. Coconut oil fatty acid diethanolamide 10 POE (20) sodium lauryl sulfate 10 1,3-butanediol 5 sulfated trehalose Na 1 water 74

Example 15 A hair tonic was prepared according to the following formulation. That is, the formulation components were heated and dissolved, and then stirred and cooled to obtain a hair tonic. 1-menthol 0.1 ethinyl estradiol 0.1 pepper tincture 0.1 sulfated trehalose Na 0.1 1,3-butanediol 5 ethanol 45 water 49.6

Example 16 A bath agent was prepared according to the following formulation. That is, the prescription components were kneaded with a kneader and divided to obtain a bath agent. Sodium carbonate 40 sodium sulfate 50 trehalose 10

Example 17 The cosmetics of Examples 1 to 12 were used for a group of 10 ICR mice (male, body weight 20 to 3).
0g) was used to examine the stimulus-protective effect. That is,
The back was shaved, 0.05 ml of cosmetic was administered, and 0.05 ml of a 1% aqueous solution of sodium lauryl sulfate was subjected to closed patching for 24 hours. This operation was repeated four times, and the scale, erythema, and conductance of the skin were measured 72 hours after the last patch was removed. Scale and erythema are very strong 2
The score was given as 1 point for the point and the clear, and 0.5 point for the weak.
The conductance (μΩ ^-1 ) was measured by a corneometer. Table 4 shows the average score and conductance. Control 1 was obtained by replacing sodium sulfated trehalose of Example 1 with water, Control 2 was obtained by replacing acetic acid trehalose of Example 9 by water, and Comparative Example 1 was obtained by using Example 1 What replaced sodium sulfated trehalose with lecithin, which is known to have a conventional skin protection function such as moisturizing action, as Comparative Example 2 was obtained by replacing the acetated trehalose of Example 9 with lecithin. Using. It can be seen that the stimulus-protecting agent of the present invention is excellent in protecting the living body from stimulus of stimulating substances.
This effect does not stem only from preventing contact with or invasion of stimulants by interfering with physical contact, that is, the fact that the stimulant protective agent of the present invention suppresses stimulus expression itself means that It is clear from the comparison with Comparative Examples 1 and 2.

[0019]

[Table 4]

[0020]

According to the present invention, it is possible to provide a means for suppressing a stimulus derived from a stimulating substance.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification number Agency reference number FI Technical display location A61K 7/40 A61K 7/40 7/48 7/48 7/50 7/50 C07H 3/04 C07H 3/04 13/00 13/00 13/06 13/06 15/04 15/04 A

Claims (8)

[Claims] 1. A stimulant protective agent comprising trehalose or a derivative thereof. 2. The stimulant protective agent according to claim 1, wherein the derivative of trehalose is sulfated trehalose or acylated trehalose. 3. A stimulus-protecting cosmetic comprising one or more selected from the stimulant-protecting agents according to claim 1. 4. The cosmetic according to claim 3, wherein the content of the stimulant protective agent according to claim 1 or 2 is 0.001 to 20% by weight. 5. The cosmetic according to claim 3, wherein the use is for skin protection, hair protection or nail protection. 6. A stimulant-protecting cosmetic containing one or more selected from trehalose or a derivative thereof. 7. The cosmetic according to claim 6, wherein the trehalose derivative is sulfated trehalose or acylated trehalose. 8. The cosmetic according to claim 6, wherein the content of one or more selected from trehalose or a derivative thereof is 0.001 to 20% by weight.