JPS58162511A - Hair nourishing composition - Google Patents

Abstract

PURPOSE:The titled safe composition having improved nourishing and growing effects on hair free from side effect, easily manufactured into an oral preparation, comprising an extract of millet, germ oil of wheat, calcium pantothenate and L-cysteine as active ingredients. CONSTITUTION:The titled composition comprising an extract of millet, germ oil of wheat, calcium pantothenate and L-cysteine as active ingredients. The extract of millet indicates a blend of a fat-soluble extract of millet and a water-soluble extract of millet, and contains VB1, VB2, nicotinamide, etc. and various kinds of amino acid. In the hair nourshing composition, the blending ratio of the amount of each active ingredient is preferably 1 extract of millet, 1-3 germ oil of wheat, 0.05-0.1 calcium pantothenate, 0.005-0.03 L-cysteine.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a hair nourishing composition for promoting hair growth and growth, preventing hair loss, and keeping hair healthy.

The causes of alopecia and abnormal hair growth are said to be blood circulation disorders in capillaries, aging and abnormalities in the hair and epidermis, and various hormone disorders, but there are still many unknowns and it is difficult to completely cure, especially When it occurs on the head, it causes cosmetic and psychological distress.

Traditionally, for the treatment and prevention of alopecia, female hormones such as etradiol, estrone, and diethylstilhestrol, which act on endocrine secretions, and corticoids, such as cortisone, hydrocortisone, and prednisolone, have been used to enhance the function of the adrenal cortex. However, there are concerns about the systemic effects of these hormones, and they have not been effective enough.

On the other hand, from a nutritional standpoint, vitamins such as vitamin E and biotin, amino acids such as leucine, threonine, and methionine, as well as unpublished vasodilators such as nicotinic acid derivatives and acetylcholine derivatives, salicylic acid and resorcinol, etc. Keratolytic agents, cefbranch/, photosensitive pigments, skin function nonadults such as capsicum and candalus tincture, and bactericidal agents such as trichlorocarbanilide and alkylisoquinolium bromide are often added to external liquids or hair cosmetics. Although it has been used as a method, sufficient effects have not been obtained.

Therefore, the present inventor has made efforts to obtain a hair-nourishing substance from crude drug extracts and processed products that have more hair-growth and hair-growth effects than ever before, and which have almost no risk from the standpoint of creative use. As a result of repeated research, we discovered that millet extract satisfactorily meets expectations, and that products containing wheat sprout oil, calcium pantothenate, L-cysteine, etc. synergistically enhance the 11 hair effect, and we have developed the present invention. It is completed.

Therefore, an object of the present invention is to provide a hair growth composition for promoting hair growth and growth, preventing hair loss, and maintaining hair health.

Another object of the present invention is to provide a composition for hair growth that does not have side effects such as systemic effects of hormones.

Furthermore, another object of the present invention is tablets, capsules,
An object of the present invention is to provide a composition for hair growth that can be easily formulated into an oral formulation such as a powder.

At least four types of active ingredients are used in the hair nourishing composition of the present invention: millet extract, wheat germ oil, calcium pantothenate, and L-cysteine. Although there is almost no research on the application of millet to medicine, the millet extract in the present invention refers to a combination of a fat-soluble extract and a water-soluble extract of millet.

The manufacturing method involves extracting acetone from millet seeds using a filtration method. The acetone extract is then distilled at normal pressure to remove acetone. The extract from which the acetone has been removed is dried with sodium sulfate, filtered to obtain an oily substance, and stored in a sealed container filled with nitrogen to prevent oxidation. In addition, the acetone extraction residue of millet is extracted with purified water by a filtration method. The aqueous extract solution is evaporated to a viscous substance under reduced pressure. The viscous material is further dried in a vacuum dryer. High-purity light silicic anhydride (Aerosil) is added to the dried product, mixed, and pulverized to size. Alternatively, silicic acid may be added to prevent coagulation.

The millet extract thus obtained has V B + , V
B2,==r Contains thinamide, Na, Mg, Fe, P salts, etc., and also contains various amino acids, among which the content of leucine is high, and also contains myriacin, lignoceric acid, erucic acid, and phospholecithin. There is.

Wheat buds are highly nutritious, containing protein, fat, minerals, and various vitamins, but it has been found that it is particularly good to use their oil from the standpoint of advanced utilization for hair growth.

The patch oil is either commercially available or is obtained as a nutritional food by a general vegetable oil manufacturing method, preferably a pressing method, from commercially available wheat sprouts or sprout-containing substances produced during milling. The obtained oil varies between 7 and 18% of the cut bud portion depending on the manufacturing method, but the component ratio does not change much, and the main fatty acid component (85%) in the cut bud oil is unsaturated fatty acids. They are about 53% linoleic acid, about 25% oleic acid, about 6% lyluic acid, and are also known to contain vitamin E.

Calcium pantothenate, also known as vitamin B5, is already used medically, and its deficiency is known to cause abnormal lipid metabolism, keratinization of the skin, and hair loss, and it is also used as a hair tonic. However, although it has been shown to be somewhat effective against alopecia caused by calcium pantothenate deficiency, it has not been sufficiently effective against alopecia of unknown cause.

L-cystine is the most abundant amino acid component in hair, and although it is not recognized as a general protein component, it is abundant in hair and keratin, and accounts for 100% of the keratin substances in hair.
About 14 tons of cystine is contained in f, and as an industrial method of producing cystine, a method of obtaining cystine by hydrolysis using hair as a raw material is also adopted.

The hair nourishing composition according to the present invention contains at least the four active ingredients described above, and the blending ratio of each active ingredient is 1 part millet extract, 1 to 3 parts wheat germ oil, and calcium pantothenate. 0.05-0.1, L-cystine o, oos~
Preferably it is 0.03.

By the way, millet extract and wheat bud oil are rich in nutritional value, and are particularly rich in minerals, vitamins, and amino acids that are essential for hair formation. It is well known that in some cases, apart from hair loss and graying due to extremely rare malnutrition, it has not been as effective as expected for general hair growth abnormalities.

In addition, pantothenic acid is a component of coenzyme A, a precursor of acetyl coenzyme, which is essential for carbohydrate and fat metabolism, and its deficiency is said to cause hair loss. Many researchers have doubts about the possibility of deficiency symptoms, as there are reports that the drug has been used to treat various symptoms that are thought to be due to deficiency, but there are also reports denying its effectiveness. be. It is also said that L-cystine exchanges redox with L-cysteine and plays an important role in metabolism as a component of glutathione in the body, but it is more active in the body than methionine. It is not an essential amino acid.

Since L-cystine is a constituent core of the keratin synthesis process essential for hair formation, attempts have been made to use it as a hair tonic, but no satisfactory effects have been obtained.

From the above, it is surprising that the composition of the present invention exhibits excellent hair growth and hair growth effects on hair growth and hair growth mechanisms that cannot be explained by mere nutritional supplementation, administration of metabolic improvers, etc. .

Next, examples of the present invention will be shown.

Example 1 70 parts by weight of millet extract, part by weight of wheat ornamental sprout oil, 5 parts by weight of calcium pantothenate, and 1 part by weight of L-cystine were mixed. tML, an oily solution is obtained. This solution was used in a conventional manner to obtain soft capsules containing 0 to 25 yi of content using a rotary continuous soft capsule automatic filling machine.

Example 2 50 parts by weight of millet extract, 100 parts by weight of barley sprout oil,
33 parts of calcium pantothenate and 1 part by weight of L-cystine are mixed, and 100 parts by weight of purified water is added while stirring to uniformly disperse and emulsify.

Next, add 50 parts of Avicel and 18 parts of cornstarch to the kneading machine.
After adding 6 parts and mixing thoroughly, add the above emulsion,
The mixture was kneaded, granulated using a crushing granulator, and dried and sized to obtain granules.

Example 3 Cornstarch 6 was added to 400f of the grain material obtained in Example 2.
0f, 33 t of calcium fibrin glycolate, 3 t of magnesium stearate, and 42 t of talc were added, mixed uniformly, and compressed using a tablet machine in a conventional manner to make 25 tablets per tablet.
0 Th') tablets were obtained.

Example 4 0.5 f millet extract was dissolved in 85 g of 6696 alcohol aqueous solution, and separately 1 g of wheat germ oil, 0.03 f of calcium pantothenate, and 12 g of L-cystine were dissolved in 14 g of propylene glycol. After dissolving, both solutions were mixed and 0.52% of fragrance was added to obtain a hair nourishing tonic.

In order to investigate whether the composition according to the present invention changes the blood flow in the skin non-nitrified blood vessels, which is thought to be related to abnormal hair growth, a test was conducted to measure the effect of increasing blood flow in the skin non-nitrified blood vessels using fulvography. Ta.

(Principle) Changes in skin thermal conductivity are expressed as a fulvograph curve using a HENaBL Fulvograph Recorder, and measured from the magnitude of the amplitude (cutaneous vascular blood flow is directly proportional to skin thermal conductivity).

(Method) The test materials were the composition obtained in Example 1 above and a placebo, and the test subjects were 18 volunteers.

On the day of the test, participants were asked to avoid foods and beverages containing alcohol and caffeine, and to avoid mental agitation prior to the measurement, they were given a demonstration of fixing the device's probe to the measurement site.

The measurement site is the bald head, the forehead, or two different locations at the same time.The probe is applied to the invisible part of the hairless vein, and the subject is made to lie down on the test bed, and the blood flow is adjusted to the normal level. A few minutes after starting the fulvography, two capsules of the test substance are administered, and a fulvograph curve is obtained before and after administration (probe movement speed: 1 c1n/min).

Table 1 Changes in skin blood flow due to administration of the composition of the present invention (
Results from fulvography for adults) From the results in the table, a total of 33 fulvograph curves were obtained, including simultaneous measurements at two locations, reproducibility tests after several days, and a plasma check, and all of the patients in the group administered with this composition showed skin blood loss. Increased flow rate (6-62%)
, and its duration was until the end of the study (25 to 8
It lasted up to 5 minutes).

Next, a test was conducted to examine the hair-nourishing effect of this composition.

(Principle) The hair in the standardized area is observed microscopically and a trichogram is created.

Trichogram shows the percentage of growing hair (tissue regeneration hair), non-growing hair (terminal hair), and intermediate phase hair (regressive hair), and the state of hair growth has changed by evaluating the tricogram before and after treatment. It can be determined whether or not. This trichogram method is currently the most useful method for objectively evaluating hair growth effects.

(Method) The test object was the capsule containing the present composition obtained in Example 1 above, and the subjects were 20 hair loss patients (19 to 65 years old, average 29.4 years old), 10 men and 10 women. be. When selecting patients, exclude patients with endocrine abnormalities, chronic inflammation of the scalp, pathological blood physiology, and those receiving embolism prevention agents or anticoagulants, and patients with low-grade fever, bullet injuries, seborrhea, hair loss of unknown cause, etc. Those who consented to the test were considered to be under a state of mental or physical stress.

Evaluation of the tricogram is carried out under standardized conditions, 2-4 days after the last shampoo and after stopping all topical treatments, before administration of the composition, i.e. after administration of capsules containing the composition 3 days a day. I continued to administer 2 capsules at a time. I did it again 6 months later.

Trichograms were taken from the parietal area, from the right side before treatment, and symmetrically from the corresponding left side after treatment. 100 hairs per test area were evaluated microscopically, always by the same investigator.

The results are shown in Table 2. This Table 2 shows tissue regenerated hair, terminal
Terminal hair and receding hair were measured before and after treatment, and the effect of the treatment was expressed in terms of %.

Table 2 (Continued from the previous page, Clothes 2) It shows an extreme decrease in hair quality and an abnormal increase in receding hair, and is also under stress.

Although the present composition was shown to be unable to prevent significant deterioration of hairy areas, it seemed justified to exclude this special patient from the statistical evaluation, and the corrected final results are presented in Table 3. Shown below.

Table 3 Table 4 shows that the results of this test differed depending on gender (excluding male patient Ahll).

Table 4 According to information from the subjects, many were satisfied with this good result, and the average number of hairs pulled per day before the treatment was 100.5, but after the treatment, the number of hairs pulled per day was the standard value of 53. decreased to

From the results in the table, the increase in tissue regenerated hair is a favorable sign, indicating the hair growth effect of the present composition.

In addition, regressed hair is considered to be the initial stage of terminal hair and is said to never develop into tissue regenerated hair, so there was no significant change in this test.

According to recent literature information, it is said that what is particularly important is the rate of change in the number of terminal hairs, and the reduction in the number of terminal hairs by treatment with the present composition was remarkable. This means that the progression from ingrown hair to terminal hair is prevented, and shows the effect of preventing hair loss.

Therefore, the composition according to the present invention not only has excellent hair nourishing and hair growth effects, but also has many advantages such as being safe without side effects such as systemic effects of hormones, and being easy to prepare for oral use. It is something that you have.

In other words, there is no safety problem since the millet extract and wheat tentacle oil in this composition are derived from natural foods, and the other ingredient, calcium pantothenate, is safe for humans. Although it has been confirmed that the composition is safe up to 10 f/day, this composition can be used in very small amounts (1/1 of the above safe amount).
6 to 1/200) is sufficient, and pantothenic acid is widely present in the animal and plant world. Furthermore, L-cystine can be considered a food, as it is added when skim milk is converted into breast milk, and moreover, only a trace amount is used here. Therefore, this composition is safe and has no side effects.

In addition, regarding the ease of formulation for oral use, conventional hair tonics have been used in shampoos, hair lotions, etc. due to the side effects of oral administration.
Most of them have to be included in hair-nourishing cosmetics, such as hair tonics, or used externally, such as creams, ointments, liquids, and emulsions, and must contain keratolytic agents in order to be effective. However, this is not necessary as the ingredients of this composition are highly safe.
Can be made into oral preparations such as tablets, capsules, powders, etc.
This eliminates skin irritation, makes it convenient to carry, and makes it easy to take a fixed amount. Methods for producing these oral preparations include conventional preformulation methods and encapsulation methods.

Conventional formulation methods using known excipients can be applied.

It goes without saying that the present composition can be made into other formulations commonly used as hair nourishing agents, such as conventional creams and emulsions.

patent applicant Hitoshi Matsuno Sakae

Claims (1)

[Claims] A hair nourishing composition comprising at least millet extract, wheat bud oil, calcium pantothenate, and L-cysteine as active ingredients.