JP2002322050A - Hair growth agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To activate hair root and promote hair growth by an oral administration by combining an ingredient activating the hair root, a raw material of the hair and an energy source for hair cells. SOLUTION: This hair growth agent is a tablet prepared by mixing 900 mg of a millet extract containing a large amount of cystine which is a raw material of the hair, 800 mg of an extract of Serenoa repens suppressing activities of 5α reductase inhibiting activities of hair-mother cells, 380 mg of citric acid as an energy source for synthesizing a protein, 200 mg of theanine which is an intracerebral amino acid mitigating a stress and 120 mg of beer yeast as a nutrient. Growing of a terminal hair is confirmed after about a half year later by internally taking 2400 mg of the hair growth agent per day.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an internally used hair growth agent for activating hair matrix cells.

[0002]

2. Description of the Related Art Extracts extracted from saw palmetto are:
It is known that it is effective as a therapeutic agent for benign prostatic hyperplasia, and it is predicted that the saw palmetto extract will act on the activation of hair matrix cells based on the action on the living body.
No. -100220 proposes to use a saw palmetto extract in a hair matrix such as a hair restorer, a hair restorer or a hair growth promoter, a hair styling agent or a shampoo in order to absorb the extract directly from the scalp into hair cells. Have been.

[0003]

However, the amount of absorption through the skin is limited even if it is to act directly on the hair root from the scalp. In some cases, it was necessary to carry a container of the hair restorer, which was troublesome. An object of the present invention is to make it possible to obtain a hair mother cell activating effect of a saw palmetto extract by oral administration and to maximize the hair activating effect of a saw palmetto extract.

[0004]

Means for Solving the Problems By mainly comprising a cystine-containing substance, a 5α-reductase activity inhibitory substance and citric acid constituting the hair, the activation of the hair mother cells, the supply of the constituent substances of the hair, and the production of hair It supplies an energy source to promote hair growth. Specifically, millet extract, which is a hair raw material containing cystine, saw palmetto extract that suppresses the activity of 5α reductase, an enzyme that inhibits energy metabolism in hair cells, and citric acid, which is important for energy production in the Krebs cycle, are the main components. Thus, the hair growth effect is developed from inside the body.

[0005] Millet extract is a natural plant component that contains a sulfur-containing amino acid that is a component of hair and is a component that has a high rate of reaching hair. Saw palmetto extract contains a component that antagonizes the inhibition of energy metabolism required for hair protein synthesis. Citrate is adenosine triphosphate (A) as an essential energy source for cells to grow and proliferate.
The present invention is an internal hair growth agent containing the above three components as main components, which is a driving force for biosynthesis of TP).

[0006] Hair is formed by changing part of the skin, and both hair and skin are composed of proteins. However, the types and proportions of amino acids constituting proteins are different between skin and hair. , The hair protein is 18
It is a type of amino acid binding and is called keratin. Table 1 shows the amino acids constituting keratin.

[0007]

[Table 1]

As can be seen from Table 1, the hair protein contains the sulfur-containing amino acid cystine at the highest content of 16%. On the other hand, cystine is 3% in skin protein
It is about. The cystine is linked to each other by a cystine bond, so that the hair is hard and elastic, and has a property of returning to its original state even when bent. Millet extract is a natural plant extract containing a large amount of this cystine.

Saw palmetto is a palm plant native to North America and a medicinal plant. The extract extracted from the ripe fruit of the saw palmetto has been used as a therapeutic agent for benign prostatic hyperplasia because it suppresses the action of the enzyme 5α reductase.

[0010]

As shown in FIGS. 1 and 2, the cause of hair loss is considered to occur in the following process. When the male hormone (testosterone) is carried by the blood and reaches the hair cells, it is converted to dihydrotestosterone (5αDHT) by 5α reductase, an enzyme in the hair cells. Dihydrotestosterone enters the cell nucleus and acts on glucose, the cell's energy source, to significantly inhibit the production of adenosine triphosphate and adversely affect glucose metabolism. That is, the pentose cycle is disturbed by dihydrotestosterone, which lowers adenyl cyclase, and further lowers cyclic AMP, thereby reducing adenosine triphosphate production.

When the production of adenosine triphosphate, which is a source of energy required for growing hair, is inhibited, the protein, which is a raw material of the hair, is not synthesized, and the hair mother cell loses its activity. It begins to keratize, becomes telogen, and falls off. Saw palmetto extract suppresses the enzyme activity of 5α reductase, reduces the production of dihydrotestosterone, prevents the production of adenosine triphosphate from being inhibited, and provides sufficient energy for hair protein synthesis. It activates hair cells and promotes hair growth.

Saw palmetto extract has a proven track record as a remedy for prostatic hypertrophy and does not suppress the activity of testosterone itself, so it does not cause side effects such as impotence, activates the activity of hair matrix cells, promotes blood circulation, and has a moisturizing effect. Excessive sebum can be suppressed.

The hair growth agent of the present invention activates the function of hair mother cells, supplements various nutrients involved in hair growth and production with daily meals and dietary supplements, and relieves stress. Hair is further promoted.

[0014]

EXAMPLES Each component in the form of powder was mixed and adjusted according to the formulation shown in Table 2 and molded into tablets. In addition to the major components of the hair growth agent of the present invention, in addition to millet extract (Chemical Research Institute, Inc.), saw palmetto extract, and citric acid, theanine (L-theanine), a component of green tea that is a kind of amino acid and effective for stress reduction, is added. In addition, hair growth inhibition from the stress side is prevented, and brewer's yeast is added as a nutrition source.

[0015]

[Table 2]

[0016] When a daily dose of 2400 mg was given to a person suffering from hair loss in each age group, the formed tablet was orally administered, and as shown in Table 2, 100% hair growth was observed.

Table 3 shows the age of the user, the type of hair loss, and the appearance time of the hair growth effect after taking Example 4 in which the hair growth effect is remarkable. In an early person, the appearance of vellus was observed 30 days after the administration, and further continued administration resulted in the appearance of hard hair. In addition, the O type of the hair removal type is a type in which the hair at the top of the head becomes thin,
The M type is a type in which both sides depilate from the hairline.

[0018]

[Table 3]

[0019]

Industrial Applicability The present invention comprises a cystine-containing substance, a millet extract, a 5α-reductase activity inhibitor, a saw palmetto extract, and citric acid as main components. Hair can be rejuvenated to the head by activating and further providing an energy source to produce the proteins that form the hair. Since the hair growth agent of the present invention is composed of a natural substance, it has no side effects and can be used internally to obtain a hair growth effect.

[Brief description of the drawings]

FIG. 1 is a diagram showing a conceptual diagram of a hair removal process and the effect of a hair growth agent.

FIG. 2 is an explanatory diagram of hair roots and hair loss.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61P 17/14 A61P 17/14 F term (Reference) 4C084 AA23 MA02 MA52 NA14 ZA921 ZC022 ZC202 4C088 AB12 AB45 AB83 AC04 AC05 BA09 BA10 MA08 MA52 NA14 ZA92 ZC02 ZC20 4C206 AA01 AA02 DA34 GA18 GA22 MA03 MA04 MA72 NA14 ZA92 ZC02 ZC20

Claims (4)

[Claims] 1. An internally-used hair growth agent containing a cystine-containing substance, a 5α-reductase activity inhibitor and citric acid as main components. 2. The internally used hair growth agent according to claim 1, wherein the cystine-containing substance is a millet extract and the 5α-reductase activity inhibitor is a saw palmetto extract. 3. The internal hair growth agent according to claim 2, further comprising theanine. 4. The method according to claim 1, wherein 34 to 40% by weight of the millet extract and 28 to 30% of the saw palmetto extract.
An internal hair growth agent comprising 37% by weight and 12 to 20% by weight of citric acid. Detailed description