JP2013119535A - Hair-growing agent composition - Google Patents
Hair-growing agent composition Download PDFInfo
- Publication number
- JP2013119535A JP2013119535A JP2011268596A JP2011268596A JP2013119535A JP 2013119535 A JP2013119535 A JP 2013119535A JP 2011268596 A JP2011268596 A JP 2011268596A JP 2011268596 A JP2011268596 A JP 2011268596A JP 2013119535 A JP2013119535 A JP 2013119535A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- hair
- acid
- component
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 47
- 239000000284 extract Substances 0.000 claims abstract description 87
- 235000002732 Allium cepa var. cepa Nutrition 0.000 claims abstract description 57
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 235000019441 ethanol Nutrition 0.000 claims abstract description 20
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 15
- 239000002738 chelating agent Substances 0.000 claims abstract description 11
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 210000004209 hair Anatomy 0.000 claims description 48
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 32
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 26
- 235000011187 glycerol Nutrition 0.000 claims description 16
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 13
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 13
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 13
- 235000005875 quercetin Nutrition 0.000 claims description 13
- 229960001285 quercetin Drugs 0.000 claims description 13
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 10
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 10
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- 229940098465 tincture Drugs 0.000 claims description 9
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 claims description 8
- 210000003780 hair follicle Anatomy 0.000 claims description 8
- 230000017531 blood circulation Effects 0.000 claims description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 6
- ILKBHIBYKSHTKQ-UHFFFAOYSA-N Diisopropylamine dichloroacetate Chemical compound OC(=O)C(Cl)Cl.CC(C)NC(C)C ILKBHIBYKSHTKQ-UHFFFAOYSA-N 0.000 claims description 6
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims description 6
- NWBJYWHLCVSVIJ-UHFFFAOYSA-N N-benzyladenine Chemical compound N=1C=NC=2NC=NC=2C=1NCC1=CC=CC=C1 NWBJYWHLCVSVIJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000012190 activator Substances 0.000 claims description 6
- -1 cephalanthin Chemical compound 0.000 claims description 6
- 229960003330 pentetic acid Drugs 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- MRAMPOPITCOOIN-VIFPVBQESA-N (2r)-n-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide Chemical compound CCOCCCNC(=O)[C@H](O)C(C)(C)CO MRAMPOPITCOOIN-VIFPVBQESA-N 0.000 claims description 5
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 5
- 235000020710 ginseng extract Nutrition 0.000 claims description 5
- 229940055726 pantothenic acid Drugs 0.000 claims description 5
- 235000019161 pantothenic acid Nutrition 0.000 claims description 5
- 239000011713 pantothenic acid Substances 0.000 claims description 5
- 150000003712 vitamin E derivatives Chemical class 0.000 claims description 5
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 claims description 4
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 claims description 4
- 240000002234 Allium sativum Species 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims description 4
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 4
- 102000010445 Lactoferrin Human genes 0.000 claims description 4
- 108010063045 Lactoferrin Proteins 0.000 claims description 4
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 4
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 claims description 4
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- 229930003427 Vitamin E Natural products 0.000 claims description 4
- 244000273928 Zingiber officinale Species 0.000 claims description 4
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 4
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 claims description 4
- 229940041514 candida albicans extract Drugs 0.000 claims description 4
- RZMKWKZIJJNSLQ-UHFFFAOYSA-M carpronium chloride Chemical compound [Cl-].COC(=O)CCC[N+](C)(C)C RZMKWKZIJJNSLQ-UHFFFAOYSA-M 0.000 claims description 4
- 229950003631 carpronium chloride Drugs 0.000 claims description 4
- 229940105990 diglycerin Drugs 0.000 claims description 4
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 4
- 229960001484 edetic acid Drugs 0.000 claims description 4
- 229960004585 etidronic acid Drugs 0.000 claims description 4
- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 claims description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
- 235000004611 garlic Nutrition 0.000 claims description 4
- 235000008397 ginger Nutrition 0.000 claims description 4
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 4
- 229940078795 lactoferrin Drugs 0.000 claims description 4
- 235000021242 lactoferrin Nutrition 0.000 claims description 4
- 239000003504 photosensitizing agent Substances 0.000 claims description 4
- 229940068041 phytic acid Drugs 0.000 claims description 4
- 235000002949 phytic acid Nutrition 0.000 claims description 4
- 239000000467 phytic acid Substances 0.000 claims description 4
- 210000002826 placenta Anatomy 0.000 claims description 4
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 claims description 4
- 229920002414 procyanidin Polymers 0.000 claims description 4
- 235000018102 proteins Nutrition 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 4
- 229940109850 royal jelly Drugs 0.000 claims description 4
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims description 4
- 229960002256 spironolactone Drugs 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 229960001367 tartaric acid Drugs 0.000 claims description 4
- 239000011709 vitamin E Substances 0.000 claims description 4
- 235000019165 vitamin E Nutrition 0.000 claims description 4
- 229940046009 vitamin E Drugs 0.000 claims description 4
- 239000012138 yeast extract Substances 0.000 claims description 4
- 229930007845 β-thujaplicin Natural products 0.000 claims description 4
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims description 3
- IZLVFLOBTPURLP-UHFFFAOYSA-N 2-Methoxy-4-nitrophenol Chemical compound COC1=CC([N+]([O-])=O)=CC=C1O IZLVFLOBTPURLP-UHFFFAOYSA-N 0.000 claims description 3
- 240000004160 Capsicum annuum Species 0.000 claims description 3
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 claims description 3
- 235000007862 Capsicum baccatum Nutrition 0.000 claims description 3
- 241000269333 Caudata Species 0.000 claims description 3
- 241000951471 Citrus junos Species 0.000 claims description 3
- 241000975394 Evechinus chloroticus Species 0.000 claims description 3
- 239000009429 Ginkgo biloba extract Substances 0.000 claims description 3
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims description 3
- 241000218657 Picea Species 0.000 claims description 3
- 241000219784 Sophora Species 0.000 claims description 3
- 244000300264 Spinacia oleracea Species 0.000 claims description 3
- 235000009337 Spinacia oleracea Nutrition 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- TTWYZDPBDWHJOR-IDIVVRGQSA-L adenosine triphosphate disodium Chemical compound [Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O TTWYZDPBDWHJOR-IDIVVRGQSA-L 0.000 claims description 3
- 239000011616 biotin Substances 0.000 claims description 3
- 229960002685 biotin Drugs 0.000 claims description 3
- 235000020958 biotin Nutrition 0.000 claims description 3
- 239000001728 capsicum frutescens Substances 0.000 claims description 3
- 229940029991 coriander extract Drugs 0.000 claims description 3
- 229940084113 diisopropylamine dichloroacetate Drugs 0.000 claims description 3
- YKZPPPNXRZHVGX-PXYKVGKMSA-L dipotassium;(2s)-2-aminobutanedioate;hydron;hydrate Chemical compound [H+].[H+].O.[K+].[K+].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O YKZPPPNXRZHVGX-PXYKVGKMSA-L 0.000 claims description 3
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 claims description 3
- 150000007946 flavonol Chemical class 0.000 claims description 3
- 235000011957 flavonols Nutrition 0.000 claims description 3
- 229940068052 ginkgo biloba extract Drugs 0.000 claims description 3
- 235000020686 ginkgo biloba extract Nutrition 0.000 claims description 3
- 229940038487 grape extract Drugs 0.000 claims description 3
- 229960003632 minoxidil Drugs 0.000 claims description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 3
- 229940068988 potassium aspartate Drugs 0.000 claims description 3
- 239000001243 zingiber officinale rosc. root absolute Substances 0.000 claims description 3
- 244000291564 Allium cepa Species 0.000 claims description 2
- 229940083256 peripheral vasodilators nicotinic acid and derivative Drugs 0.000 claims description 2
- 241000234282 Allium Species 0.000 abstract description 56
- 230000000694 effects Effects 0.000 abstract description 24
- 108010029908 3-oxo-5-alpha-steroid 4-dehydrogenase Proteins 0.000 abstract description 21
- 102000001779 3-oxo-5-alpha-steroid 4-dehydrogenase Human genes 0.000 abstract description 21
- 239000000419 plant extract Substances 0.000 abstract description 9
- 230000005764 inhibitory process Effects 0.000 abstract description 4
- 239000000306 component Substances 0.000 description 32
- 230000003779 hair growth Effects 0.000 description 19
- 230000002401 inhibitory effect Effects 0.000 description 16
- 201000004384 Alopecia Diseases 0.000 description 12
- 208000024963 hair loss Diseases 0.000 description 11
- 230000003676 hair loss Effects 0.000 description 11
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 210000003491 skin Anatomy 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 239000002537 cosmetic Substances 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000009471 action Effects 0.000 description 6
- 210000004761 scalp Anatomy 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 238000013329 compounding Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 229960003604 testosterone Drugs 0.000 description 5
- 239000002677 5-alpha reductase inhibitor Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 235000019437 butane-1,3-diol Nutrition 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 229940113178 5 Alpha reductase inhibitor Drugs 0.000 description 3
- 102000001307 androgen receptors Human genes 0.000 description 3
- 108010080146 androgen receptors Proteins 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000031774 hair cycle Effects 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- XBLVHTDFJBKJLG-UHFFFAOYSA-N Ethyl nicotinate Chemical compound CCOC(=O)C1=CC=CN=C1 XBLVHTDFJBKJLG-UHFFFAOYSA-N 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 2
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 229960003473 androstanolone Drugs 0.000 description 2
- 230000002280 anti-androgenic effect Effects 0.000 description 2
- 239000000051 antiandrogen Substances 0.000 description 2
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000010903 husk Substances 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- YNBADRVTZLEFNH-UHFFFAOYSA-N methyl nicotinate Chemical compound COC(=O)C1=CC=CN=C1 YNBADRVTZLEFNH-UHFFFAOYSA-N 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 229960001295 tocopherol Drugs 0.000 description 2
- 235000010384 tocopherol Nutrition 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
- VNFYMAPAENTMMO-UHFFFAOYSA-N 5-chloro-2-methylquinoline Chemical compound ClC1=CC=CC2=NC(C)=CC=C21 VNFYMAPAENTMMO-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 235000005255 Allium cepa Nutrition 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 241000218645 Cedrus Species 0.000 description 1
- 235000001258 Cinchona calisaya Nutrition 0.000 description 1
- 241001660788 Cinchona calisaya Species 0.000 description 1
- 244000089795 Clausena lansium Species 0.000 description 1
- 235000008738 Clausena lansium Nutrition 0.000 description 1
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 240000006550 Lantana camara Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 240000003889 Piper guineense Species 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 241000219492 Quercus Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 240000001417 Vigna umbellata Species 0.000 description 1
- 235000011453 Vigna umbellata Nutrition 0.000 description 1
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 229960003001 adenosine triphosphate disodium Drugs 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229940008075 allyl sulfide Drugs 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229950004580 benzyl nicotinate Drugs 0.000 description 1
- 239000001058 brown pigment Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 229940099418 d- alpha-tocopherol succinate Drugs 0.000 description 1
- 239000003398 denaturant Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- SNPLKNRPJHDVJA-UHFFFAOYSA-N dl-panthenol Chemical compound OCC(C)(C)C(O)C(=O)NCCCO SNPLKNRPJHDVJA-UHFFFAOYSA-N 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 229940064982 ethylnicotinate Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 229950006191 gluconic acid Drugs 0.000 description 1
- 210000000442 hair follicle cell Anatomy 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- RVYGVBZGSFLJKH-UHFFFAOYSA-N hexyl pyridine-3-carboxylate Chemical compound CCCCCCOC(=O)C1=CC=CN=C1 RVYGVBZGSFLJKH-UHFFFAOYSA-N 0.000 description 1
- 229940051295 hexylnicotinate Drugs 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940049918 linoleate Drugs 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 229940098895 maleic acid Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 229960001238 methylnicotinate Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 150000002948 pantothenic acids Chemical class 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 208000017497 prostate disease Diseases 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940095585 testosterone-5-alpha reductase inhibitors for benign prostatic hypertrophy Drugs 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 230000003813 thin hair Effects 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、タマネギ外皮抽出物を有効成分として含み、安定性および育毛効果に優れる育毛剤組成物に関する。 The present invention relates to a hair restorer composition comprising an onion hull extract as an active ingredient and having excellent stability and hair growth effect.
ストレスの多い現代社会においては、脱毛の原因の一因とされているストレスを取り除くことは困難に等しく、男女問わず、抜け毛又は薄毛に悩む人が増えている。このため、より優れた「育毛料」が常に望まれており、提供すべく様々な試みがなされている。 In a modern society with a lot of stress, it is equally difficult to remove stress that is a cause of hair loss, and an increasing number of people suffer from hair loss or thin hair regardless of gender. For this reason, a better “hair-growth material” has always been desired, and various attempts have been made to provide it.
男性ホルモンの１種であるテストステロンは、還元酵素であるテストステロン５α−レダクターゼにより還元され、作用の強いジヒドロテストステロンになる。生成されたジヒドロテストステロンは、毛乳頭においてレセプターと結合して複合体を形成し、特定のＤＮＡに作用することによってｍＲＮＡの発現を介してある種のタンパク質が合成され、これが毛包上皮系細胞に働いて、毛成長又は毛周期（ヘアサイクル）に異常を引き起こし、毛包を萎縮させ、脱毛を誘発する原因となることが知られている。従って、抗男性ホルモン作用又は抗男性ホルモン作用の機序のひとつであるテストステロン５α−レダクターゼ阻害作用を有する薬剤は育毛作用があると考えられている。すなわち、テストステロン５α−レダクターゼ阻害作用を有する薬剤を得ることができれば、これにより、頭皮機能を高め、脱毛を防止し、毛髪の発毛、成長又は正常化を促すことができる育毛剤を得ることができる。 Testosterone, a type of male hormone, is reduced by testosterone 5α-reductase, which is a reductase, to dihydrotestosterone having a strong action. The produced dihydrotestosterone binds to a receptor in the hair papilla to form a complex, which acts on specific DNA to synthesize certain proteins through the expression of mRNA, which is expressed in hair follicle epithelial cells. It is known to work and cause abnormalities in hair growth or hair cycle (hair cycle), causing hair follicles to shrink and inducing hair loss. Therefore, it is considered that a drug having testosterone 5α-reductase inhibitory action, which is one of anti-androgenic action or anti-androgen action, has a hair-growth action. That is, if a drug having testosterone 5α-reductase inhibitory action can be obtained, it is possible to obtain a hair restorer that can enhance scalp function, prevent hair loss, and promote hair growth, growth or normalization of hair. it can.
テストステロン５α−レダクターゼ阻害作用を示す物質としては、ステロイド物質、女性ホルモン、及び多くの植物抽出物が知られており、特に天然物を由来とする物質が望まれている。 As substances showing testosterone 5α-reductase inhibitory action, steroid substances, female hormones, and many plant extracts are known, and substances derived from natural products are particularly desired.
有効成分として植物抽出物を含むテストステロン５α−レダクターゼ阻害剤、及びそれらを含む育毛剤又は養毛剤に関しては、多くの報告がある（例えば、特許文献１〜５）。特許文献１には、くまつづら科植物であるランタナ（Lantana camara L.）の根部から水、脂肪族低級アルコール、１，３−ブチレングリコール、またはこれらの混合物等により抽出されるテストステロン５α−レダクターゼ阻害物質を有効成分とするテストステロン５α−レダクターゼ阻害剤、ならびにこれを含有させてなる頭髪化粧料および皮膚化粧料が記載されている。また、特許文献２には、ワンピ属ミカン科に属する常緑小高木である、「黄皮」（学名：Ｃｌａｕｓｅｎａ ｌａｎｓｉｕｍ（Ｌｏｕｒ．）Ｓｋｅｅｌｓ）の葉に、テストステロン５α−レダクターゼ阻害作用とアンドロゲン受容体結合阻害作用の両方を有する物質が含まれており、男性ホルモン過剰による頭皮疾患の改善に有効で安全性にも優れた養毛化粧料を提供することができることが記載されている。特許文献３には、紅豆杉、烏欖、幌傘楓、穿心蓮からなる群から選ばれた１種若しくは２種以上の植物抽出物が、テストステロン５α−レダクターゼ阻害作用及び／又はアンドロゲン受容体結合阻害作用を示し、これらを用いて、養毛化粧料、前立腺肥大抑制剤、健康補助食品を得られることが記載されている。特許文献４には、ムラサキ科チシャノキ属植物（特にチャングバット）から抽出されるテストステロン５α−レダクターゼ阻害物質及びアンドロゲン受容体結合阻害物質を有効成分として含有する抗男性ホルモン剤、及び養毛化粧料、皮脂分泌抑制剤並びに前立腺肥大抑制剤が記載されている。特許文献５には、クエルカス（Ｑｕｅｒｃｕｓ）属に属する植物またはその抽出物を含有するテストステロン５α−レダクターゼ阻害剤、育毛剤、ニキビの予防および／または治療剤、前立腺疾患の予防および／または治療剤が記載されている。しかしながら、これらの製品は、育毛効果が不十分であったり、副作用があったりして、いまだ満足する育毛剤は得られていない。 There are many reports on testosterone 5α-reductase inhibitors containing plant extracts as active ingredients, and hair restorers or hair nourishing agents containing them (for example, Patent Documents 1 to 5). Patent Document 1 discloses that testosterone 5α-reductase is extracted from the root of Lantana camara L., which is extracted with water, an aliphatic lower alcohol, 1,3-butylene glycol, or a mixture thereof. A testosterone 5α-reductase inhibitor containing a substance as an active ingredient, and a hair cosmetic and a skin cosmetic containing the same are described. Patent Document 2 discloses a testosterone 5α-reductase inhibitory action and androgen receptor binding on the leaves of “yellow bark” (scientific name: Clausena lansium (Lour.) Skels), which is an evergreen small tree belonging to the genus Ranunculaceae. It describes that a hair nourishing cosmetic that contains both substances having an inhibitory action, is effective in improving scalp disease caused by excess male hormones, and is excellent in safety can be provided. In Patent Document 3, one or two or more plant extracts selected from the group consisting of red bean cedar, cocoon, hooded umbrella, and shinshin lotus have testosterone 5α-reductase inhibitory action and / or androgen receptor binding inhibition. It is described that it can be used to obtain hair nourishing cosmetics, prostate hypertrophy inhibitors, and health supplements. Patent Document 4 discloses an anti-androgen agent containing a testosterone 5α-reductase inhibitor and an androgen receptor binding inhibitor extracted from a plant belonging to the genus Muranoceae (especially Changbat) as an active ingredient, and a hair nourishing cosmetic, Sebum secretion inhibitors and prostate hypertrophy inhibitors are described. Patent Document 5 discloses a testosterone 5α-reductase inhibitor, a hair restorer, a prophylactic and / or therapeutic agent for acne, and a prophylactic and / or therapeutic agent for prostate disease containing a plant belonging to the genus Quercus or an extract thereof. Have been described. However, these products have insufficient hair-growth effects and have side effects, so that no satisfactory hair-growth agents have yet been obtained.
本発明の目的は、テストステロン５α−レダクターゼ阻害作用を有する新規な植物抽出物を見出し、その植物抽出物が安定に存在し、育毛効果に優れた育毛剤組成物を提供することにある。 An object of the present invention is to find a novel plant extract having a testosterone 5α-reductase inhibitory action, and to provide a hair restorer composition that has a stable plant extract and is excellent in hair growth effect.
本発明者は、上記のような実情を鑑み、鋭意検討を重ねた結果、タマネギ外皮抽出物がテストステロン５α−レダクターゼ阻害作用を有すること、及びこのタマネギ外皮抽出物とキレート剤等とを組み合わせれば、タマネギ外皮抽出物が広いｐＨ領域の水溶液中でも安定に存在することを見出し、さらに検討を加えて本発明を完成するに至った。 As a result of intensive studies in view of the above situation, the present inventor has found that the onion hull extract has a testosterone 5α-reductase inhibitory action and combines this onion hull extract with a chelating agent and the like. The present inventors have found that the onion husk extract is stably present even in an aqueous solution having a wide pH range, and have further studied to complete the present invention.
即ち、本発明は、以下の育毛剤組成物を提供する。
項１． （Ａ）タマネギ外皮抽出物、
（Ｂ）キレート剤、
（Ｃ）多価アルコール、及び
（Ｄ）エチルアルコール
を含有し、ｐＨが４．５〜９である育毛剤組成物であって、前記成分（Ｃ）の含有量が、前記組成物中１０質量％以下であり、かつ、前記成分（Ａ）１質量部に対して１５質量部以上であることを特徴とする育毛剤組成物。
項２． 前記成分（Ａ）が、ケルセチンを含む上記項１に記載の育毛剤組成物。
項３． 前記成分（Ｂ）が、酒石酸、フィチン酸、エチレンジアミン四酢酸、ジエチレントリアミン五酢酸、ヒドロキシエチルエチレンジアミン三酢酸、ヒドロキシエタンジホスホン酸、及びそれらの塩、及びラクトフェリンからなる群から選ばれる１種又は２種以上である上記項１又は２に記載の育毛剤組成物。
項４． 前記成分（Ｃ）が、グリセリン、ジグリセリン及び１，３−ブタンジオールからなる群から選ばれる１種又は２種以上である上記項１〜３のいずれかに記載の育毛剤組成物。
項５． さらに、（Ｅ）血行促進剤および（Ｆ）毛包賦活剤を含む上記項１〜４のいずれかに記載の育毛剤組成物。
項６． 前記成分（Ｅ）が、ビタミンＥ及びビタミンＥ誘導体、ニコチン酸及びその誘導体、ビタミンＢ６塩酸塩、Ｌ−メントール、セファランチン、塩化カルプロニウム、スピロノラクトン、γ−オリザノール、ミノキシジル、ジイソプロピルアミンジクロロアセテート、センブリ抽出物、朝鮮人参抽出物、チンピ抽出物、イチョウ葉抽出物、キナ抽出物、ショウブ根抽出物、ソフォラ抽出液、トウヒ抽出物、当薬抽出物、ユズ抽出物、トウガラシチンキ、カンタリスチンキ及びショウキョウチンキからなる群から選ばれる１種又は２種以上である上記項５に記載の育毛剤組成物。
項７． 前記成分（Ｆ）が、パントテン酸及びその誘導体、Ｎ−アシルアミノ酸、ペンタデカン酸グリセリド、６−ベンジルアミノプリン、プロシアニジン、アデノシン三リン酸二ナトリウム、アスパラギン酸カリウム、フラバノノール、感光素３０１号、ニンニク成分、ローヤルゼリー、ビオチン、モノニトログアヤコール、６−ベンジルアミノプリン、ジイソプロピルアミンジクロル酢酸、ヒノキチオール、パントテニルエチルエーテル、プラセンタエキス、真珠蛋白抽出物、酵母抽出物、タマサキツヅラフジ抽出物、ブドウ抽出物、リンゴ抽出物、サンショウ抽出物、コリアンダー抽出物及びヒレハリソウ抽出物からなる群から選ばれる１種又は２種以上である請求項５又は６に記載の育毛剤組成物。
That is, the present invention provides the following hair restorer composition.
Item 1. (A) Onion hull extract,
(B) a chelating agent,
(C) Polyhydric alcohol and (D) A hair restorer composition containing ethyl alcohol and having a pH of 4.5 to 9, wherein the content of the component (C) is 10% in the composition. %, And it is 15 parts by mass or more based on 1 part by mass of the component (A).
Item 2. The hair restorer composition according to Item 1, wherein the component (A) contains quercetin.
Item 3. The component (B) is one or two selected from the group consisting of tartaric acid, phytic acid, ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, hydroxyethylethylenediaminetriacetic acid, hydroxyethanediphosphonic acid, and salts thereof, and lactoferrin The hair restorer composition according to Item 1 or 2 above.
Item 4. The hair restorer composition according to any one of Items 1 to 3, wherein the component (C) is one or more selected from the group consisting of glycerin, diglycerin and 1,3-butanediol.
Item 5. Furthermore, the hair-restoring agent composition in any one of said claim | item 1-4 containing (E) blood circulation promoter and (F) hair follicle activator.
Item 6. The component (E) is vitamin E and vitamin E derivatives, nicotinic acid and derivatives thereof, vitamin B6 hydrochloride, L-menthol, cephalanthin, carpronium chloride, spironolactone, γ-oryzanol, minoxidil, diisopropylamine dichloroacetate, assembly extract Ginseng extract, chimpan extract, ginkgo biloba extract, kina extract, ginger root extract, sophora extract, spruce extract, medicinal extract, yuzu extract, red pepper tincture, cantalis tincture and ginger Item 6. The hair restorer composition according to Item 5, which is one or more selected from the group consisting of tinctures.
Item 7. The component (F) is pantothenic acid and derivatives thereof, N-acylamino acid, pentadecanoic acid glyceride, 6-benzylaminopurine, procyanidin, disodium adenosine triphosphate, potassium aspartate, flavonol, photosensitizer 301, garlic component , Royal jelly, biotin, mononitroguaiacol, 6-benzylaminopurine, diisopropylamine dichloroacetic acid, hinokitiol, pantothenyl ethyl ether, placenta extract, pearl protein extract, yeast extract, Tamazaki tsumugi extract, grape extract, The hair-restoring agent composition according to claim 5 or 6, which is one or more selected from the group consisting of an apple extract, a salamander extract, a coriander extract and a spinach extract.
本発明の育毛剤組成物は、有効成分として植物抽出物であるタマネギ外皮抽出物を用いているので、副作用などがなく安全である。さらに、本発明の育毛剤組成物は、（Ａ）タマネギ外皮抽出物とともに、（Ｂ）キレート剤、（Ｃ）多価アルコール及び（Ｄ）エチルアルコールを必須成分として含むので、タマネギ外皮抽出物の有するテストステロン５α−レダクターゼ阻害作用を、ｐＨ４．５〜９という広いｐＨ領域で発揮させることができ、優れた育毛効果を得ることができる。さらに、（Ｅ）血行促進剤および（Ｆ）毛包賦活剤と組み合わせて用いることで、より育毛効果に優れた育毛剤組成物を得ることができる。 The hair restorer composition of the present invention uses an onion peel extract, which is a plant extract, as an active ingredient, and is therefore safe with no side effects. Furthermore, since the hair restorer composition of the present invention contains (B) chelating agent, (C) polyhydric alcohol and (D) ethyl alcohol as essential components together with (A) onion skin extract, The testosterone 5α-reductase inhibitory action possessed can be exhibited in a wide pH range of pH 4.5 to 9, and an excellent hair-growth effect can be obtained. Furthermore, by using it in combination with (E) a blood circulation promoter and (F) a hair follicle activator, a hair restorer composition having a more excellent hair growth effect can be obtained.
本発明の育毛剤組成物は、必須成分として（Ａ）タマネギ外皮抽出物（以下、「成分（Ａ）」ともいう）、（Ｂ）キレート剤（以下、「成分（Ｂ）」ともいう）、（Ｃ）多価アルコール（以下、「成分（Ｃ）」ともいう）、及び（Ｄ）エチルアルコール（以下、「成分（Ｄ）」ともいう）を含有する。 The hair restorer composition of the present invention comprises (A) onion peel extract (hereinafter also referred to as “component (A)”), (B) chelating agent (hereinafter also referred to as “component (B)”) as essential components. (C) Polyhydric alcohol (hereinafter also referred to as “component (C)”) and (D) ethyl alcohol (hereinafter also referred to as “component (D)”).
本発明に用いる（Ａ）タマネギ外皮抽出物は、ネギ科（クロンキスト体系ではユリ科）ネギ属タマネギ（学名：Allium cepa）の外皮から得られる。タマネギの外皮とは、タマネギの鱗茎部分を覆っているうす茶色の皮のことであって、食することができないため、通常は捨てられる部分である。タマネギの外皮には、主成分としてポリフェノールの一種である茶色の色素成分のケルセチン（クエルセチン）が多く含まれることが知られており、本発明の育毛剤組成物におけるタマネギ外皮抽出物の作用はこのケルセチンによるところが大きい。タマネギ外皮には、ケルセチン以外に、硫化アリル、ビタミンＡ、Ｂ１、Ｂ２などが含まれている。ケルセチンを主として含む本発明のタマネギ外皮抽出物は、公知の方法により得ることができる。 The (A) onion hull extract used in the present invention is obtained from the hull of the onion genus onion (scientific name: Allium cepa). The onion hull is a light brown skin covering the bulb portion of the onion, and it is a part that is normally discarded because it cannot be eaten. The onion skin is known to contain a large amount of quercetin (quercetin), a brown pigment component, which is a kind of polyphenols, as the main component. The action of the onion skin extract in the hair restorer composition of the present invention is The place by quercetin is big. The onion hull contains allyl sulfide, vitamins A, B1, B2 and the like in addition to quercetin. The onion peel extract of the present invention mainly containing quercetin can be obtained by a known method.
具体的には、タマネギ外皮を４０〜８０質量％のエタノール水溶液に浸漬し、２０〜６０℃程度の温度で０．５〜４時間程度インキュベーションし、濾過又は遠心して上清を採取し、上清から溶媒を除去して得られた溶液を蒸発乾固またはフリーズドライすることにより、タマネギ外皮抽出物の粉末を得ることができる。別の方法として、タマネギ外皮を熱湯にて抽出した後、木粉に吸着させ、タマネギ外皮抽出物担持リグノセルロースを得てから、溶媒を用いて溶出させる方法もある。 Specifically, the onion skin is immersed in a 40 to 80% by mass ethanol aqueous solution, incubated at a temperature of about 20 to 60 ° C. for about 0.5 to 4 hours, filtered or centrifuged, and the supernatant is collected. The onion hull extract powder can be obtained by evaporating to dryness or freeze-drying the solution obtained by removing the solvent from. As another method, there is a method in which an onion hull is extracted with hot water and then adsorbed to wood flour to obtain an onion hull extract-carrying lignocellulose and then eluted with a solvent.
ケルセチンには、経口摂取により、抗酸化、血糖降下、抗癌又は血圧降下作用、毛細血管を丈夫にする働き等があることが知られており、新陳代謝を活発にし、疲労回復に効果があり、タマネギ外皮をそのまま粉末化したりして、健康食品等に多く利用されている。 Quercetin is known to have antioxidation, hypoglycemic, anticancer or antihypertensive action, and action to make capillaries strong by oral ingestion. Onion husk is powdered as it is and is often used for health foods.
しかしながら、タマネギ外皮抽出物及びケルセチンは、着色するという問題があり、さらに水への溶解性が悪く、安定化が難しいことから、育毛剤に利用されたという報告はない。 However, onion peel extract and quercetin have a problem that they are colored, and since they are poorly soluble in water and difficult to stabilize, there is no report that they have been used for hair restorers.
タマネギ外皮抽出物の育毛剤組成物中の配合量は、固形分で０．０５〜１．５質量％が好ましく、０．１〜１質量％がさらに好ましい。０．０５質量％未満では、テストステロン５α−レダクターゼ阻害作用による十分な育毛効果が得られない。１．５質量％を超えても、それ以上の効果を期待することができない。 0.05-1.5 mass% is preferable at solid content, and, as for the compounding quantity in the hair-growth agent composition of an onion peel extract, 0.1-1 mass% is more preferable. If it is less than 0.05% by mass, sufficient hair-growth effect due to testosterone 5α-reductase inhibitory action cannot be obtained. Even if it exceeds 1.5% by mass, no further effect can be expected.
本発明に用いられる成分（Ｂ）のキレート剤としては、サリチル酸、酒石酸、アスコルビン酸、マレイン酸、グルコン酸、フィチン酸、エチレンジアミン四酢酸、ジエチレントリアミン五酢酸、ヒドロキシエチルエチレンジアミン三酢酸、ヒドロキシエタンジホスホン酸、及びそれらの塩、ポリリン酸ナトリウム、メタリン酸ナトリウム、ヘキサメタリン酸ナトリウム、ラクトフェリン、カフェイックアシッド、ピロガロールなどが挙げられる。塩としては、ナトリウム塩、カリウム塩、アンモニウム塩、アルカノールアミン塩等が挙げられる。 As the chelating agent of component (B) used in the present invention, salicylic acid, tartaric acid, ascorbic acid, maleic acid, gluconic acid, phytic acid, ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, hydroxyethylethylenediaminetriacetic acid, hydroxyethanediphosphonic acid And salts thereof, sodium polyphosphate, sodium metaphosphate, sodium hexametaphosphate, lactoferrin, caffeic acid, pyrogallol and the like. Examples of the salt include sodium salt, potassium salt, ammonium salt, alkanolamine salt and the like.
タマネギ外皮抽出物は、溶媒の存在下、ｐＨ７．５以上のアルカリ域では安定に存在することができるが、ｐＨ７．５未満のｐＨ域では、ケルセチンが不溶化し沈殿を生じやすい。ケルセチンは不溶化することにより、生理活性が消失し、ケルセチンの有する作用を発揮できない。本発明では、上記のキレート剤と特定の溶媒とを組み合わせることで、ｐＨ４．５〜９の領域で、タマネギ外皮抽出物を安定に存在させることを可能にした。 The onion hull extract can exist stably in the alkaline region of pH 7.5 or higher in the presence of a solvent, but in the pH region of less than pH 7.5, quercetin is insoluble and easily precipitates. When quercetin is insolubilized, the physiological activity disappears and the action of quercetin cannot be exhibited. In the present invention, by combining the above-mentioned chelating agent and a specific solvent, the onion peel extract can be stably present in the pH range of 4.5-9.
これらのキレート剤のうち、酒石酸、フィチン酸、エチレンジアミン四酢酸、ジエチレントリアミン五酢酸、ヒドロキシエチルエチレンジアミン三酢酸、ヒドロキシエタンジホスホン酸、及びそれらの塩、及びラクトフェリンからなる群から選ばれる１種又は２種以上が、タマネギ外皮抽出物の安定化効果に優れる点で、特に好ましい。 Among these chelating agents, one or two selected from the group consisting of tartaric acid, phytic acid, ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, hydroxyethylethylenediaminetriacetic acid, hydroxyethanediphosphonic acid, and salts thereof, and lactoferrin The above is particularly preferable in that the effect of stabilizing the onion skin extract is excellent.
キレート剤の育毛剤組成物中の配合量は、０．００１〜１質量％が好ましく、０．１〜０．５質量％がさらに好ましい。０．００１質量％未満では、ｐＨ７．５未満で、タマネギ外皮抽出物が凝集沈殿を生じやすく、１質量％を超えても、タマネギ外皮抽出物の安定性に関わる影響はない。 0.001-1 mass% is preferable and the compounding quantity in the hair restorer composition of a chelating agent has more preferable 0.1-0.5 mass%. If it is less than 0.001% by mass, the onion hull extract tends to cause aggregation precipitation at a pH of less than 7.5, and even if it exceeds 1% by mass, there is no influence on the stability of the onion hull extract.
タマネギ外皮抽出物を、育毛剤組成物中に安定に存在させるために必要な溶媒として、成分（Ｃ）の多価アルコールを使用する。（Ｃ）多価アルコールとしては、グリセリン、ジグリセリン、１，３−ブタンジオール、プロピレングリコール、ジプロピレングリコール、１，２−ペンタンジオール等が挙げられる。グリセリンとしては、日本薬局方グリセリン（商品名）（グリセリン濃度８４〜８７％）、化粧品用濃グリセリン（商品名）（グリセリン濃度９８．５％以上）等を用いることができる。成分（Ｃ）は、タマネギ外皮抽出物中に含まれるケルセチンの溶解性向上に寄与するだけでなく、育毛剤組成物において頭皮を柔軟にし、他の薬効成分と共存して相乗効果を示す上で重要な役目を果たしている。このように多価アルコールは、頭皮に対しては柔軟剤又は保湿剤として有用であるが、髪に必要以上に吸着されると、髪のボリュームを低下させる、湿気が吸いやすくなる、ベタツキによりゴミが付着しやすくなるなどの弊害が生じる。このため、成分（Ｃ）の含有量は、育毛剤組成物中１０質量％以下が好ましい。 The polyhydric alcohol of component (C) is used as a solvent necessary for the onion hull extract to be stably present in the hair restorer composition. (C) Examples of the polyhydric alcohol include glycerin, diglycerin, 1,3-butanediol, propylene glycol, dipropylene glycol, and 1,2-pentanediol. As glycerin, Japanese Pharmacopoeia glycerin (trade name) (glycerin concentration of 84 to 87%), concentrated glycerin for cosmetics (trade name) (glycerin concentration of 98.5% or more) and the like can be used. Ingredient (C) not only contributes to improving the solubility of quercetin contained in the onion peel extract, but also makes the scalp soft in the hair-restoring agent composition and exhibits a synergistic effect in combination with other medicinal ingredients. It plays an important role. In this way, polyhydric alcohol is useful as a softening agent or moisturizing agent for the scalp, but if it is adsorbed more than necessary, it reduces the volume of the hair, makes it easier to absorb moisture, and makes it dusty due to stickiness. Detrimental effects such as easy adhesion. For this reason, the content of the component (C) is preferably 10% by mass or less in the hair restorer composition.
これらの多価アルコールの中で、特にグリセリン、ジグリセリン及び１，３−ブタンジオールが、タマネギ外皮抽出物の溶解性向上に寄与してタマネギ外皮抽出物の安定化を促す点で好ましい。しかしながら、タマネギ外皮抽出物に対する多価アルコールの割合が低いと、タマネギ外皮抽出物と多価アルコールとの相溶姓が悪く、時間の経過とともに凝集、沈降、変色などを生じやすくなる。よって、この問題を回避するためには、タマネギ外皮抽出物１質量部に対して、これらの多価アルコールが、１５質量部以上必要である。 Among these polyhydric alcohols, glycerin, diglycerin and 1,3-butanediol are particularly preferable because they contribute to improving the solubility of the onion hull extract and promote stabilization of the onion hull extract. However, when the ratio of the polyhydric alcohol to the onion hull extract is low, the compatibility between the onion hull extract and the polyhydric alcohol is poor, and aggregation, sedimentation, discoloration, and the like tend to occur over time. Therefore, in order to avoid this problem, 15 parts by mass or more of these polyhydric alcohols are required for 1 part by mass of the onion skin extract.
さらに一価のアルコールである（Ｄ）のエチルアルコールも、溶媒として必要である。エチルアルコールとして、合成エチルアルコール、発酵エチルアルコール、変性剤を添加した変性エチルアルコール等を単独若しくは２種以上を適宜組み合わせて用いることができる。エチルアルコールは、多価アルコールと共存して、タマネギ外皮抽出物の安定化を促し、さらにタマネギ外皮抽出物およびその他の薬効成分の経皮吸収を促す目的で添加される。このように、タマネギ外皮抽出物による育毛効果を発揮させる上で、多価アルコール及びエチルアルコールは重要な役目を果たす。 Further, ethyl alcohol (D) which is a monohydric alcohol is also required as a solvent. As ethyl alcohol, synthetic ethyl alcohol, fermented ethyl alcohol, denatured ethyl alcohol to which a denaturant is added can be used alone or in combination of two or more. Ethyl alcohol is added for the purpose of promoting the stabilization of the onion hull extract and the percutaneous absorption of the onion hull extract and other medicinal ingredients in the presence of polyhydric alcohol. Thus, polyhydric alcohol and ethyl alcohol play an important role in exerting the hair-growth effect by the onion hull extract.
成分（Ｄ）の育毛剤組成物中の配合量は、１〜７０質量％が好ましく、３〜６５質量％がさらに好ましい。１質量％未満では、薬効成分の頭皮への経皮吸収効果は低く、７０質量％を超えても、タマネギ外皮抽出物の安定性又は育毛効果に関わる影響は見られない。 1-70 mass% is preferable, and, as for the compounding quantity in the hair restorer composition of a component (D), 3-65 mass% is more preferable. If it is less than 1% by mass, the effect of percutaneous absorption of the medicinal component to the scalp is low, and even if it exceeds 70% by mass, there is no influence on the stability or hair-growth effect of the onion peel extract.
本発明の育毛剤組成物は、さらに（Ｅ）血行促進剤および（Ｆ）毛包賦活剤を含むことができる。 The hair restorer composition of the present invention may further contain (E) a blood circulation promoter and (F) a hair follicle activator.
成分（Ｅ）の血行促進剤としては、ビタミンＥ及びビタミンＥ誘導体、ニコチン酸及びその誘導体、ビタミンＢ６塩酸塩、Ｌ−メントール、セファランチン、塩化カルプロニウム、スピロノラクトン、γ−オリザノール、ミノキシジル、ジイソプロピルアミンジクロロアセテート、センブリ抽出物、朝鮮人参抽出物、チンピ抽出物、イチョウ葉抽出物、キナ抽出物、ショウブ根抽出物、ソフォラ抽出液、トウヒ抽出物、当薬抽出物、ユズ抽出物、トウガラシチンキ、カンタリスチンキ、ショウキョウチンキなどを用いることができる。ビタミンＥ誘導体として、酢酸トコフェロール、（リノール酸／オレイン酸）トコフェロール、コハク酸トコフェロール、ニコチン酸トコフェロール、リノール酸トコフェロール等が挙げられる。ニコチン酸誘導体として、ニコチン酸エチル、ニコチン酸トコフェロール、ニコチン酸ヘキシル、ニコチン酸ベンジル、ニコチン酸メチル等が挙げられる。 As the blood circulation promoter of component (E), vitamin E and vitamin E derivatives, nicotinic acid and its derivatives, vitamin B6 hydrochloride, L-menthol, cephalanthin, carpronium chloride, spironolactone, γ-oryzanol, minoxidil, diisopropylamine dichloroacetate , Ginseng extract, ginseng extract, ginkgo biloba extract, kina extract, ginger root extract, sophora extract, spruce extract, medicinal extract, yuzu extract, red pepper tincture, cantalis Tincture, ginger tincture, etc. can be used. Examples of vitamin E derivatives include tocopherol acetate, (linoleic acid / oleic acid) tocopherol, tocopherol succinate, tocopherol nicotinate, tocopherol linoleate and the like. Examples of the nicotinic acid derivative include ethyl nicotinate, tocopherol nicotinate, hexyl nicotinate, benzyl nicotinate, and methyl nicotinate.
これら血行促進剤の中で、ビタミンＥ及びビタミンＥ誘導体、ニコチン酸及びその誘導体、ビタミンＢ６塩酸塩、セファランチン、塩化カルプロニウム、スピロノラクトン、γ−オリザノール、センブリ抽出物、朝鮮人参抽出物、チンピ抽出物、トウガラシチンキ、及びショウキョウチンキが、血行を有効に促進し、優れた育毛作用が得られる点で特に好ましい。 Among these blood circulation promoters, vitamin E and vitamin E derivatives, nicotinic acid and its derivatives, vitamin B6 hydrochloride, cephalanthin, carpronium chloride, spironolactone, γ-oryzanol, assembly extract, ginseng extract, chimpan extract, Pepper tincture and ginger tincture are particularly preferable because they effectively promote blood circulation and provide an excellent hair-growth effect.
成分（Ｅ）の配合量としては、育毛剤組成物中に０．０１〜３質量％が好ましく、０．１〜１質量％がさらに好ましい。０．０１質量％未満では、十分な育毛効果が得られず、３質量％を超えても、効果に影響はなく、かえってべたつきなどの不快感を与えたり、刺激を感じるなどの不都合が生じ、好ましくない。 As a compounding quantity of a component (E), 0.01-3 mass% is preferable in a hair restorer composition, and 0.1-1 mass% is further more preferable. If the amount is less than 0.01% by mass, a sufficient hair-growth effect cannot be obtained. If the amount exceeds 3% by mass, the effect is not affected, and inconvenience such as stickiness or irritation occurs. It is not preferable.
成分（Ｆ）の毛包賦活剤としては、パントテン酸及びその誘導体、Ｎ−アシルアミノ酸、ペンタデカン酸グリセリド、６−ベンジルアミノプリン、プロシアニジン、アデノシン三リン酸二ナトリウム、アスパラギン酸カリウム、フラバノノール、感光素３０１号、ニンニク成分、ローヤルゼリー、ビオチン、モノニトログアヤコール、６−ベンジルアミノプリン、ジイソプロピルアミンジクロル酢酸、ヒノキチオール、パントテニルエチルエーテル、プラセンタエキス、真珠蛋白抽出物、酵母抽出物、タマサキツヅラフジ抽出物、ブドウ抽出物、リンゴ抽出物、サンショウ抽出物、コリアンダー抽出物、ヒレハリソウ抽出物などを用いることができる。パントテン酸誘導体として、Ｄ−パントテニルアルコール、ＤＬ−パントテニルアルコール、パントテニルエチルエーテル、アラントインパントテニルアルコール、パントテン酸ポリペプチド等が挙げられる。 Component (F) hair follicle activator includes pantothenic acid and its derivatives, N-acylamino acid, pentadecanoic acid glyceride, 6-benzylaminopurine, procyanidin, disodium adenosine triphosphate, potassium aspartate, flavonol, photosensitizer No. 301, garlic component, royal jelly, biotin, mononitroguaiacol, 6-benzylaminopurine, diisopropylamine dichloroacetic acid, hinokitiol, pantothenyl ethyl ether, placenta extract, pearl protein extract, yeast extract, tamasaki samurai extract Grape extract, apple extract, salamander extract, coriander extract, spinach extract and the like can be used. Examples of pantothenic acid derivatives include D-pantothenyl alcohol, DL-pantothenyl alcohol, pantothenyl ethyl ether, allantoinpantothenyl alcohol, pantothenic acid polypeptide, and the like.
これらの毛包賦活剤の中で、パントテン酸及びその誘導体、プロシアニジン、アデノシン三リン酸二ナトリウム、感光素３０１号、ニンニク成分、ローヤルゼリー、ヒノキチオール、パントテニルエチルエーテル、プラセンタエキス、及び酵母抽出物が、毛包細胞を効率よく活性化し、優れた育毛作用が得られる点で特に好ましい。 Among these hair follicle activators, pantothenic acid and its derivatives, procyanidin, adenosine triphosphate disodium, photosensitizer 301, garlic component, royal jelly, hinokitiol, pantothenyl ethyl ether, placenta extract, and yeast extract It is particularly preferable in that hair follicle cells are efficiently activated and an excellent hair-growth effect is obtained.
成分（Ｆ）の配合量としては、育毛剤組成物中に０．０１〜５質量％が好ましく、０．１〜１質量％がさらに好ましい。０．０１質量％未満では、十分な育毛効果が得られず、５質量％を超えても、効果に影響はなく、かえってべたつくなどの不快感を与えてしまい、好ましくない。 As a compounding quantity of a component (F), 0.01-5 mass% is preferable in a hair restorer composition, and 0.1-1 mass% is further more preferable. If it is less than 0.01% by mass, a sufficient hair-growth effect cannot be obtained, and if it exceeds 5% by mass, the effect is not affected, and it causes an unpleasant feeling such as stickiness.
本発明の育毛剤組成物には、上記成分以外に、他の成分として化粧品や医薬部外品などに分類する育毛剤の配合成分として一般的に用いられる、界面活性剤、油脂類、上記記載の多価アルコール以外の保湿剤、エチルアルコール以外の一価アルコール、防腐剤、植物抽出物、抗炎症剤、色素、香料などを適宜配合することができる。 In the hair restorer composition of the present invention, in addition to the above-mentioned components, surfactants, fats and oils, and the above-mentioned description, which are generally used as a component for hair restorers classified as cosmetics and quasi-drugs as other components Moisturizers other than polyhydric alcohols, monohydric alcohols other than ethyl alcohol, preservatives, plant extracts, anti-inflammatory agents, pigments, fragrances, and the like can be appropriately blended.
本発明の育毛剤組成物の形態としては、液状、ゲル状、乳液状、エアゾール等の剤型で製剤化することが可能であるが、使い易さ及び用法を考慮すると、液状又はエアゾール状が本発明の効果を発揮されやすく好ましい。 As the form of the hair restorer composition of the present invention, it can be formulated in a liquid form, a gel form, an emulsion form, an aerosol form or the like, but in consideration of ease of use and usage, the liquid form or the aerosol form may be used. The effect of the present invention is easily exhibited and is preferable.
以下に本発明の実施例を示すことにより、本発明を詳細に説明するが、本発明はこれによって何ら限定されるものではない。 Examples The present invention will be described in detail below by showing examples of the present invention, but the present invention is not limited to these examples.
テストステロン５α−レダクターゼ阻害作用を測定するために、タマネギ外皮抽出物を調製した。タマネギ外皮抽出物は、グリセリンを溶媒として用いたものを試料とした。 To measure the testosterone 5α-reductase inhibitory effect, an onion peel extract was prepared. An onion peel extract was prepared using glycerin as a solvent.
［製造例１：タマネギ外皮抽出物の２質量％グリセリン溶液の調製］
タマネギ外皮を洗浄した後、乾燥させて粉砕したもの１００ｇに、５０％エタノール水溶液１Ｌを添加し、４０℃で２時間インキュベートした。次いで、得られた混合物を濾過し、上清を採取した。上清に含まれる溶媒を除去して上清を蒸発乾固させることにより、タマネギ外皮抽出物約２ｇを得た。得られたタマネギ外皮抽出物１ｇとジエチレントリアミン五酢酸五ナトリウム０．１ｇをグリセリンに溶解し、タマネギ外皮抽出物を２質量％の濃度で含むグリセリン溶液（５０ｇ）を得た。
[Production Example 1: Preparation of 2% by mass glycerin solution of onion peel extract]
After washing the onion skin, 1 L of 50% ethanol aqueous solution was added to 100 g of the dried and pulverized product and incubated at 40 ° C. for 2 hours. The resulting mixture was then filtered and the supernatant was collected. The solvent contained in the supernatant was removed and the supernatant was evaporated to dryness to obtain about 2 g of onion peel extract. 1 g of the onion hull extract obtained and 0.1 g of diethylenetriaminepentaacetic acid pentasodium were dissolved in glycerin to obtain a glycerin solution (50 g) containing the onion hull extract at a concentration of 2% by mass.
［製造例２：タマネギ外皮抽出物の２質量％グリセリン溶液の調製］
浸漬する溶媒として４０％エタノール水溶液を用い、６０℃で２時間インキュベーションを行う以外は、製造例１と同様にしてタマネギ外皮抽出物約２ｇを得た。得られたタマネギ外皮抽出物１ｇとジエチレントリアミン五酢酸五ナトリウム０．１ｇをグリセリンに溶解し、タマネギ外皮抽出物を２質量％の濃度で含むグリセリン溶液（５０ｇ）を得た。
[Production Example 2: Preparation of 2% by mass glycerin solution of onion peel extract]
About 2 g of onion peel extract was obtained in the same manner as in Production Example 1 except that a 40% ethanol aqueous solution was used as a solvent to be immersed and incubation was performed at 60 ° C. for 2 hours. 1 g of the onion hull extract obtained and 0.1 g of diethylenetriaminepentaacetic acid pentasodium were dissolved in glycerin to obtain a glycerin solution (50 g) containing the onion hull extract at a concentration of 2% by mass.
［テストステロン５α−レダクターゼ阻害作用の測定］
試料として、製造例１および２のタマネギ外皮抽出物（２質量％濃度）を用いて、以下の公知の方法により、テストステロン５α−レダクターゼ阻害作用の測定を行った。まずプロピレングリコール１ｍＬにテストステロン４．２ｍｇを溶解し、得られた溶液の２０μＬに１ｍｇ／ｍＬのＮＡＤＰＨを含有する５ｍｍｏｌ／ｍＬＴｒｉｓ−ＨＣｌ緩衝液８２５μＬ（ｐＨ７．２）を加えて混合した。これに各濃度に希釈した被験試料８０μＬ、及びＳ−９（ラット肝ホモジネート）７５μＬを混合し、３５分間（３７℃）反応させた後、塩化メチレン１ｍＬを加えて反応を停止させた。次に遠心分離により塩化メチレン層を分取し、テストステロン残存量をＨＰＬＣにより定量した。対照として、溶媒だけを用いて同様に処理して定量した。内部標準物質として４−ヒドロキシ安息香酸ブチルを用いた。陽性試料には、テストステロン５α−レダクターゼ阻害活性を有することが公知であるエチニルエストラジオールを用いた。また、製造例１および２のタマネギ外皮抽出物（２％濃度）を４０℃で２週間保存したものについても上記と同様にして測定を行った。
[Measurement of testosterone 5α-reductase inhibitory action]
Using the onion peel extract (2% by mass concentration) of Production Examples 1 and 2 as a sample, the testosterone 5α-reductase inhibitory action was measured by the following known method. First, 4.2 mg of testosterone was dissolved in 1 mL of propylene glycol, and 825 μL of 5 mmol / mL Tris-HCl buffer solution (pH 7.2) containing 1 mg / mL NADPH was added to 20 μL of the obtained solution and mixed. 80 μL of the test sample diluted to each concentration and 75 μL of S-9 (rat liver homogenate) were mixed and reacted for 35 minutes (37 ° C.), and then 1 mL of methylene chloride was added to stop the reaction. Next, the methylene chloride layer was separated by centrifugation, and the residual amount of testosterone was quantified by HPLC. As a control, the same treatment was performed using only the solvent, and quantification was performed. 4-Hydroxybenzoate was used as an internal standard substance. As the positive sample, ethinyl estradiol, which is known to have testosterone 5α-reductase inhibitory activity, was used. Moreover, the onion peel extract (2% concentration) of Production Examples 1 and 2 was stored at 40 ° C. for 2 weeks, and the measurement was performed in the same manner as described above.
酵素活性を５０％阻害する試料濃度ＩＣ５０（ｍｇ／ｍＬ）を下記式：
阻害率（％）＝１００×［（ａ−ｂ）／ａ］
ａ：対照（テストステロン変換％）
ｂ：試料（テストステロン変換％）
により計算し、阻害率を求めた。結果を表１に示す。
The sample concentration IC 50 (mg / mL) that inhibits the enzyme activity by 50% is expressed by the following formula:
Inhibition rate (%) = 100 × [(ab) / a]
a: Control (testosterone conversion%)
b: Sample (testosterone conversion%)
And the inhibition rate was obtained. The results are shown in Table 1.
［試験結果］
表１の結果からわかるように、本発明に用いられるタマネギ外皮抽出物は、高いテストステロン５α−レダクターゼ阻害作用を有することが確認された。４０℃で２週間保管したものについても、同程度のテストステロン５α−レダクターゼ阻害作用を維持していた。
[Test results]
As can be seen from the results in Table 1, it was confirmed that the onion peel extract used in the present invention has a high testosterone 5α-reductase inhibitory action. The same testosterone 5α-reductase inhibitory effect was maintained for those stored at 40 ° C. for 2 weeks.
さらに、本発明の育毛剤組成物の処方例を以下に示す。 Furthermore, the formulation example of the hair restorer composition of this invention is shown below.
実施例１〜３及び比較例１の育毛剤組成物は、室温下にて１〜１０の成分を順次混合し、最後に、１１及び１２の成分を予め混合させておいたものを加え、プロペラで撹拌し、可溶化したことを確認した後、取り出した。 The hair restoration compositions of Examples 1 to 3 and Comparative Example 1 were prepared by sequentially mixing the components 1 to 10 at room temperature, and finally adding the components 11 and 12 previously mixed, It was taken out after confirming that it was solubilized.
［使用試験］
実施例１〜３及び比較例１の育毛剤組成物を用いて、使用試験を行った。２０〜５０歳の男性型脱毛症の男性被験者１０名に対し、朝夕の一日２回、患部に連続３ヶ月間いずれかの試料を使用した。以下の評価基準に従い、毛髪の増加度、及び洗髪時の抜け毛の減少度合いを基準に、育毛効果を専門の評価者により評価した。毛髪の増加度は、３ヶ月後の頭皮の状態を写真撮影したものを用いて評価した。洗髪時の抜け毛の減少度合いについては、自己評価にて判断した。
[Use test]
Using the hair restorer compositions of Examples 1 to 3 and Comparative Example 1, a use test was performed. For 10 male male alopecias aged 20-50 years old, any sample was used twice a day in the morning and evening for 3 consecutive months. According to the following evaluation criteria, the hair growth effect was evaluated by a professional evaluator based on the degree of increase in hair and the degree of decrease in hair loss during shampooing. The degree of increase in hair was evaluated using a photograph of the state of the scalp after 3 months. The degree of decrease in hair loss during shampooing was judged by self-evaluation.
［評価基準１：毛髪の増加度］
◎：試験開始前に比べ明らかな増加が確認された
○：試験開始前に比べて１〜２割の増加が確認された
△：試験開始前と特に変化は見られなかった
×：試験開始前より毛髪が減少した
[Evaluation criteria 1: Increase in hair]
◎: A clear increase was confirmed compared with before the start of the test. ○: An increase of 10 to 20% was confirmed compared with before the start of the test. △: No particular change was observed before the start of the test. More hair loss
［評価基準２：洗髪時の抜け毛の減少度合い］
◎：明らかに抜け毛が減少した
○：試験開始前よりは抜け毛が減った
△：特に変化は見られなかった
×：試験開始前より抜け毛が増えた
[Evaluation criteria 2: Degree of reduction in hair loss during hair washing]
◎: Hair loss clearly decreased ○: Hair loss decreased from before the start of the test Δ: No particular change was observed ×: Hair loss increased from before the start of the test
表２に示した通り、実施例１〜３の本発明の育毛剤組成物は、明らかな育毛効果を発揮することが確認された。それに比べ、（Ｂ）キレート剤を含まない比較例１は、実施例と同様に（Ａ）タマネギ外皮抽出物を含むにも関わらず、安定性が悪く、十分な育毛効果を発揮しないことが確認された。 As shown in Table 2, it was confirmed that the hair restorer compositions of the present invention of Examples 1 to 3 exhibited an obvious hair-restoring effect. In contrast, (B) Comparative Example 1 containing no chelating agent was confirmed to be poor in stability and not exhibit a sufficient hair-growth effect even though it contained (A) onion hull extract as in the examples. It was done.
Claims (7)
（Ｂ）キレート剤、
（Ｃ）多価アルコール、及び
（Ｄ）エチルアルコール
を含有し、ｐＨが４．５〜９である育毛剤組成物であって、前記成分（Ｃ）の含有量が、前記組成物中１０質量％以下であり、かつ、前記成分（Ａ）１質量部に対して１５質量部以上であることを特徴とする育毛剤組成物。 (A) Onion hull extract,
(B) a chelating agent,
(C) Polyhydric alcohol and (D) A hair restorer composition containing ethyl alcohol and having a pH of 4.5 to 9, wherein the content of the component (C) is 10% in the composition. %, And it is 15 parts by mass or more based on 1 part by mass of the component (A).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011268596A JP5769611B2 (en) | 2011-12-08 | 2011-12-08 | Hair restorer composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011268596A JP5769611B2 (en) | 2011-12-08 | 2011-12-08 | Hair restorer composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013119535A true JP2013119535A (en) | 2013-06-17 |
| JP5769611B2 JP5769611B2 (en) | 2015-08-26 |
Family
ID=48772357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011268596A Expired - Fee Related JP5769611B2 (en) | 2011-12-08 | 2011-12-08 | Hair restorer composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5769611B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105534788A (en) * | 2015-12-25 | 2016-05-04 | 苏州春上枝头化妆品有限公司 | Production technology of alopecia-stopping and hair-generating hair washing product |
| WO2018207952A1 (en) * | 2017-05-12 | 2018-11-15 | 国立大学法人九州大学 | Composition for hair growth and/or hair restoration |
| JP2020529406A (en) * | 2017-08-07 | 2020-10-08 | シムライズ アーゲー | Extracts of Coprinus comatus and their use to regulate hair follicle sebaceous gland units in humans |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3332055A1 (en) * | 1983-09-06 | 1985-03-21 | Jolanta 7505 Ettlingen Zimirikas | Hair growth promoter and process for its production |
| JPS61178910A (en) * | 1985-02-02 | 1986-08-11 | Akio Fujikawa | Hair dressing agent for growing and nourishing hair |
| JPH0248514A (en) * | 1988-08-11 | 1990-02-19 | Shiseido Co Ltd | Hair tonic |
| JPH0377809A (en) * | 1989-08-21 | 1991-04-03 | Arusoa Sogo Kenkyusho:Kk | Hair tonic |
| WO1996010387A2 (en) * | 1994-09-30 | 1996-04-11 | The Boots Company Plc | Hair stimulant composition |
| JP2004512304A (en) * | 2000-10-25 | 2004-04-22 | ジュリアーニ ソシエタ ペル アチオニ | Pharmaceutical or dietary combination of catechin and quercetin |
| DE102007040025A1 (en) * | 2007-08-24 | 2009-02-26 | Muhamad Karwan | Hair restorer, useful e.g. for external application on skin and as shampoo, conditioner, hair tonic and lotion, comprises component of aqueous extract of bulbous plant (Alliaceae) and/or bulbous plant oil |
| US20090087498A1 (en) * | 2007-03-28 | 2009-04-02 | Barnard Robert A | Shampoo formulation for treatment of hair loss and method of use |
| JP2010518180A (en) * | 2007-02-13 | 2010-05-27 | レガシー ヘルスケア ホールディング リミテッド | Novel cosmetic and / or pharmaceutical compositions and their uses |
-
2011
- 2011-12-08 JP JP2011268596A patent/JP5769611B2/en not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3332055A1 (en) * | 1983-09-06 | 1985-03-21 | Jolanta 7505 Ettlingen Zimirikas | Hair growth promoter and process for its production |
| JPS61178910A (en) * | 1985-02-02 | 1986-08-11 | Akio Fujikawa | Hair dressing agent for growing and nourishing hair |
| JPH0248514A (en) * | 1988-08-11 | 1990-02-19 | Shiseido Co Ltd | Hair tonic |
| JPH0377809A (en) * | 1989-08-21 | 1991-04-03 | Arusoa Sogo Kenkyusho:Kk | Hair tonic |
| WO1996010387A2 (en) * | 1994-09-30 | 1996-04-11 | The Boots Company Plc | Hair stimulant composition |
| JP2004512304A (en) * | 2000-10-25 | 2004-04-22 | ジュリアーニ ソシエタ ペル アチオニ | Pharmaceutical or dietary combination of catechin and quercetin |
| JP2010518180A (en) * | 2007-02-13 | 2010-05-27 | レガシー ヘルスケア ホールディング リミテッド | Novel cosmetic and / or pharmaceutical compositions and their uses |
| US20090087498A1 (en) * | 2007-03-28 | 2009-04-02 | Barnard Robert A | Shampoo formulation for treatment of hair loss and method of use |
| DE102007040025A1 (en) * | 2007-08-24 | 2009-02-26 | Muhamad Karwan | Hair restorer, useful e.g. for external application on skin and as shampoo, conditioner, hair tonic and lotion, comprises component of aqueous extract of bulbous plant (Alliaceae) and/or bulbous plant oil |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105534788A (en) * | 2015-12-25 | 2016-05-04 | 苏州春上枝头化妆品有限公司 | Production technology of alopecia-stopping and hair-generating hair washing product |
| WO2018207952A1 (en) * | 2017-05-12 | 2018-11-15 | 国立大学法人九州大学 | Composition for hair growth and/or hair restoration |
| JPWO2018207952A1 (en) * | 2017-05-12 | 2020-04-16 | 国立大学法人九州大学 | Hair growth and / or hair growth composition |
| JP2020529406A (en) * | 2017-08-07 | 2020-10-08 | シムライズ アーゲー | Extracts of Coprinus comatus and their use to regulate hair follicle sebaceous gland units in humans |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5769611B2 (en) | 2015-08-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7054242B2 (en) | Hair papilla cell activation promoter and VEGF production promoter | |
| US9408795B2 (en) | Method for enhancing the growth and fullness of hair | |
| JP2006282597A (en) | Hair papilla cell growth promoter, vascular endothelial growth factor (vegf) production promoter and hair-restoring or growing agent | |
| JP2007022923A (en) | Hair follicle apoptosis reaction inhibitor and hair cosmetic composition | |
| JP5769611B2 (en) | Hair restorer composition | |
| JP2008239545A (en) | Elastase deactivator | |
| KR101965595B1 (en) | Composition for prevention of losing hair or promotion of growing hair | |
| KR20100024322A (en) | Shampoo composition for alopecia prevention and hair growth | |
| KR101307304B1 (en) | Composition for treating hair or scalp to prevent hair loss and promote growing hair | |
| JPS63211214A (en) | Hair tonic | |
| KR101984745B1 (en) | Cosmetic composition for promoting hair growth comprising extract mixture of Houttuynia cordata, Calendula arvensis and Phellinus linteus as effective component | |
| EP1317239B1 (en) | Synergetic combinations based on plants for treating hair loss | |
| JP2019206490A (en) | Mixed component having 5α-reductase inhibitory action, and composition for hair growth containing the same | |
| US10543227B2 (en) | Hair growth composition | |
| JP2001139435A (en) | Hair-growing agent | |
| JPH1087440A (en) | Hair tonic cosmetic | |
| KR101826006B1 (en) | Hair cosmetic composition containing natural dyeing material | |
| JP2011148792A (en) | Hair-growing agent | |
| JP5303225B2 (en) | Gray hair improver | |
| JP5666344B2 (en) | Hair restorer | |
| JPH06256142A (en) | Hair tonic | |
| JP6883320B2 (en) | Hair pigment enhancer | |
| JP2003238435A (en) | TESTSTERONE 5alpha-REDUCTASE INHIBITOR | |
| WO2000045782A1 (en) | TESTOSTERONE-5α-REDUCTASE INHIBITORS, HAIR GROWTH STIMULANT/HAIR NOURISHMENT COMPOSITIONS AND COMPOSITIONS FOR WHITENING COSMETICS | |
| JP2001253808A (en) | Hair growing cosmetic |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20140919 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20150428 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150602 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150623 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5769611 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |