JP2007022923A - Hair follicle apoptosis reaction inhibitor and hair cosmetic composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hair follicle apoptosis inhibitor having prevention of fallen hair caused by hair follicle apoptosis and growth promotion effect of healthy hair thereby, and a hair cosmetic composition in which the hair follicle apoptosis inhibitor is formulated. <P>SOLUTION: The hair follicle apoptosis inhibitor excellent in effects comprises both of the antioxidant and the antiinflammatory substance. The hair cosmetic composition is obtained by using the hair follicle apoptosis inhibitor. The antioxidant includes piroctone olamine, a plant extract selected from a specific group, carotenoid, ascorbic acid, coenzyme Q10, glutathione or the like. The antiinflammatory substance includes glycyrrhetic acid and/or its derivative, glycyrrhizic acid and/or its derivative, allantoin, a plant extract selected from a group other than that of the antioxidant. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a hair follicle apoptosis reaction inhibitor excellent in hair loss prevention effect and promoting the growth of healthy hair, and a hair cosmetic composition comprising a hair follicle apoptosis reaction inhibitor.

  The scalp is exposed to oxidative stress such as lipid peroxide generated by the action of fatty acids and ultraviolet rays caused by excessive secretion of sebum or the decomposition of sebum by scalp microorganisms, and hydrogen peroxide used when using coloring agents. ing. Conventionally, as an effect of oxidative stress on a living body, it is known to damage hair extending outside the scalp, and various compositions for reducing such damage have been disclosed.

However, there has been little research on the effects of oxidative stress generated on the surface of the scalp on the hair follicle organs existing deep in the scalp, and therefore no composition has been disclosed for these. .
On the other hand, an agent for preventing and suppressing gray hair and an anti-dandruff / itching agent using glycyrrhetinic acid, which is an anti-inflammatory agent, and piroctone olamine, which is an anti-oxidant, has already been disclosed (Patent Document 1). No mention is made of the effect of hair loss or the effect of preventing hair loss.
JP 2001-89329 A

  An object of the present invention is to provide a hair cosmetic composition containing a hair follicle apoptosis inhibitor, and a hair follicle apoptosis inhibitor that has the effect of preventing hair loss caused by hair follicle apoptosis and thereby promoting the growth of healthy hair. It is in.

  As a result of investigating the influence of oxidative stress of the scalp on the hair follicle organ, which has been unknown until now, it was found that lipid peroxide or hydrogen peroxide causes a reaction called apoptosis in the hair follicle. As is well known, hair growth is controlled along a certain period, which is divided into a growth phase where hair grows, a regression phase where growth stops, and a resting phase where no growth is seen. Of these, the apoptotic response is known to occur during the regression phase. As a result of further investigation, it was also found that the scalp oxidative stress shifts to the regression phase earlier than usual. From these results, it was found that the oxidative stress of the scalp has an adverse effect on hair growth as well as hair damage that has been said conventionally.

  By reducing the negative effects on hair follicles caused by the oxidative stress generated on the scalp surface, it prevents hair loss caused by damage caused to hair follicles, thereby promoting healthy hair growth and preventing hair loss. In order to achieve the purpose of providing a hair cosmetic composition having an excellent effect, the present inventors have conducted intensive research. As a result, only when an antioxidant and an anti-inflammatory substance are used in combination, the intended action is achieved. As a result, the present invention has been completed.

That is, the present invention is a hair follicle apoptosis inhibitor comprising <1> an antioxidant and an anti-inflammatory substance.
<2> Anti-inflammatory substance is glycyrrhetinic acid and / or its derivative, glycyrrhizic acid and / or its salt, allantoin, aloe vera extract, altea extract, ginkgo biloba extract, ginger extract, ginseng extract, red ginger extract, chamomile extract, Kawara mugwort extract, yellow aloe extract, gardenia extract, kumazasa extract, cape aloe extract, linden extract, birch bark extract, horsetail extract, sage extract, sage extract, mallow extract, assembly extract, suhakuhi extract, clove extract, toki extract, tow Calendula extract, Dokudami extract, Bukuryo extract, Loofah extract, Safflower extract, Bacillic alcohol, Mukuroji extract, Button extract, Yukinoshita extract, Artemisia <1> a hair follicle apoptosis inhibitor comprising one or more selected from the group consisting of an extract, a bituminous extract, aspirin, indomethacin, and fernavik.
<3> Antioxidants include piroctone olamine, ashitaba extract, oolong tea extract, turmeric extract, ougon extract, ouren extract, oryzanol, rice bran ferment extract, rice germ oil, comfrey extract, perilla extract, peonies extract, soybean extract, It contains at least one selected from the group consisting of tea extract, tocopherol, tocotrienol, loquat leaf extract, maroni extract, lactoferrin, lavender extract, rosemary extract, carotenoid, ascorbic acid, coenzyme Q10 and glutathione. <1> or <2> is a hair follicle apoptosis inhibitor.
<4> A hair composition comprising the hair follicle apoptosis inhibitor according to <1> to <3> as an active ingredient.

  Glycyrrhizic acid and / or its salt, glycyrrhetinic acid and / or its derivative, which are anti-inflammatory agents of the present invention, include glycyrrhizic acid, ammonium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate, β-glycyrrhetinic acid, glycyrrhetin Examples include acid stearyl, among which β-glycyrrhetinic acid and dipotassium glycyrrhizinate are preferable.

  The antioxidant used in the present invention is preferably a hydroxypyridone derivative, and examples thereof include 1-hydroxy-4-methyl-6-phenyl-pyridone, hydroxy-4-methyl-pyridone, and piroctone olamine. Kutonolamine is particularly preferred.

The compounding amount of the anti-inflammatory substance in the composition of the present invention is usually 0.001 to 2.0%, preferably 0.01 to 1.0%, and more preferably 0.05 to 0.5%. . If the amount is too small, a sufficient effect may not be obtained.
In addition, the amount of the antioxidant substance in the composition of the present invention is usually 0.001 to 2.0%, preferably 0.005 to 1.0%, particularly 0.01 to 0.5%. More preferred. If the blending amount is too small, a sufficient effect may not be obtained. If the blending amount is too large, the possibility of causing skin irritation increases, which does not meet the object of the present invention.

The composition of the present invention has a known medicinal component such as a blood circulation promoter, a cell activator, an antiandrogen, a moisturizer, an amino acid, in order to enhance the effect of reducing the adverse effect of oxidative stress on the hair follicle. Etc. can be blended. Moreover, optional components other than the above-mentioned medicinal components, for example, purified water, ethanol, celluloses, surfactants, fats and oils, ester oils, polymer resins, coloring materials, fragrances, ultraviolet absorbers and the like can be blended. .
When a fragrance is blended in the hair composition of the present invention, a commonly used fragrance can be used in an ordinary amount. For example, according to the fragrance | flavor and fragrance | flavor composition described in Unexamined-Japanese-Patent No. 2003-95895, it is suitable to mix | blend so that a fragrance composition may be 0.00001-50 mass% with respect to liquid composition whole quantity, More preferably, it is 0. 0001-30 mass% is mix | blended.

  The hair cosmetic composition of the present invention can be used in the form of a uniform solution, lotion, gel, cream, aerosol or the like according to a conventional method.

Hereinafter, the present invention will be described with reference to examples and comparative examples, but the present invention is not limited thereto. In the following examples,% is mass%.
(Test example)
The back skin of the mouse was subjected to 6 square centimeter hair removal treatment, and the compositions of Test Examples 1 and 2 and Comparative Examples 1 to 3 shown in the following table were applied once a day for 50 μl for 1 week. Thereafter, 0.1% linolenic acid peroxide was applied to induce an apoptotic reaction of the hair follicle due to oxidative stress. One day after the application of linolenic acid peroxide, the dorsal skin was collected, and apoptosis-positive cells were stained with a commercially available apoptosis detection kit (TACS2 apoptosis detection kit: Trevigen). The percentage of numbers was calculated.

  As shown in Table 1, antioxidant substances (pyrocton olamine in Table 1) and anti-inflammatory substances (glycyrrhetinic acid in Table 1) alone cannot prevent the apoptotic reaction that occurs in the hair follicles, but they should be used together It was found that it was possible to prevent hair follicle apoptosis.

(Examples 1-4, Comparative Examples 4-8)
The tonic agents of Examples 1 to 4 and Comparative Examples 4 to 8 shown in Table 2 were prepared, and their hair loss prevention was evaluated. Hair growth tonic agents having the compositions shown in Table 2 were produced by a conventional method, and tested for anti-dandruff effect when they were used and for preventing hair loss during hair washing. The test method is as follows. The results are shown in Table 2.

(Test method)
1: Hair loss prevention effect 100 men who have a large number of hair loss at the time of shampooing and have noticed that their hair has become slightly thin are divided into 10 groups of 10 men, and 1 hair-growth tonic agent is prepared for each group. The dose was 2 mL once a day and applied to the scalp for 1 month. For each, the relative value (B /) of the average number of hair loss per person (A) when shampooing for 3 consecutive days before the start of application and the average number of hair loss per person (B) when shampooing for 3 consecutive days after use one month. A × 100) and the sum of the relative values was averaged by the number of people.

  As shown in Table 2, antioxidative agent piroctone olamine and anti-inflammatory agent glycyrrhetinic acid alone do not show a hair loss reduction effect, but it is found that they can be prevented by using in combination. did.

A hair cosmetic composition having the following composition was produced by a conventional method.
Example 5 (essence for scalp)
Isopropyl methylphenol 0.1%
Aloe vera extract 0.5
Polyethylene glycol 400 0.1
DL-α-tocopherol acetate 0.1
Polyoxyethylene oleyl ether (10EO) 2.0
Sucrose myristic acid ester 0.5
Coleus extract 0.5
Succinic acid 0.3
L-Menthol 0.3
Fragrance 0.05
Methylparaben 0.1
95% ethanol 20
Purified water balance

Example 6 (hair growth tonic)
Isopropyl methylphenol 0.1%
Allantoin 1.0
Polyethylene glycol 300 0.1
Pentadecanoic acid glyceride 2.5
Rosemary extract 0.1
Polyoxyethylene stearyl ether (20EO) 2.0
Yuka Former AMPHOSET (Mitsubishi Chemical) 0.5
Isopropyl myristate 3.0
L-Menthol 0.2
Fragrance 0.05
99% ethanol 80
Purified water balance

Example 7 (hair restorer)
Isopropyl methylphenol 0.1%
Oat extract 0.5
Polyethylene glycol 400 0.1
Polyoxyethylene stearyl ether (20EO) 2.0
Lactoferrin 0.1
L-Menthol 0.2
Fragrance 0.05
99% ethanol 80
Purified water balance

Example 8 (hair restorer)
6-Benzylaminopurine 3.0%
Polyoxyethylene lauryl ether (10EO) 2.0
β-glycyrrhetinic acid 1.0
Hinokitiol 0.5
Polyethylene glycol 200 1.0
Piroctone olamine 0.1
Isotridecyl myristate 2.0
Methylphenylpolysiloxane 2.0
L-Menthol 0.1
Octyl gallate 0.1
Fragrance 0.05
99% ethanol 70
Purified water balance

Example 9 (hair restorer)
Assembly extract 3.0%
Pantotheniether 0.5
Zinc pyrithione 1.0
Polyethylene glycol 2000 0.5
Polyoxyethylene lauryl ether (10EO) 2.0
POE (40) hardened castor oil 0.5
Tocotrienol 1.0
L-Menthol 0.1
Citric acid 0.1
Fragrance 0.05
99% ethanol 20
Purified water balance

Example 10 (hair restorer)
Sage extract 1.0%
Polyethylene glycol 600 1.0
Piroctone olamine 0.05
Polyoxyethylene oleyl ether (20EO) 2.0
Glutathione 0.1
Isopropyl palmitate 2.0
Methylphenylpolysiloxane 2.0
L-Menthol 0.1
Echinashi leaf extract 1.0
Coleus extract 0.2
Fragrance 0.05
99% ethanol 70
Purified water balance

Example 11 (hair restorer)
Mallow extract 0.1%
Polyethylene glycol 600 3.0
β-glycyrrhetinic acid 0.05
Isopropyl methylphenol 0.05
Polyoxyethylene oleyl ether (20EO) 2.0
Perilla extract 0.1
Isopropyl palmitate 2.0
Methylphenylpolysiloxane 2.0
L-Menthol 0.1
Echinashi leaf extract 1.0
Fragrance 0.05
99% ethanol 80
Purified water balance

Example 12 (hair growth spray)
(Undiluted solution)
Ginkgo biloba 0.2
Polyethylene glycol 600 2.0
Ashitaba Extract 1.0
Sorbitan laurate 0.5
Ethyl oleate 0.1
Citric acid 0.3
Sucrose laurate 0.5
Fragrance 0.1
L-Menthol 0.1
99% ethanol remaining (stock solution / propellant: LPG) 80/20

Example 13 (hair growth cream)
A oil phase
Rice germ oil 0.2%
Isopropylmethylphenol 0.1
Dimethyl silicone gum (degree of polymerization 12000) 1.0
Dimethyl silicone (degree of polymerization 500) 0.1
Ethyl oleate 2.0
Octyldodecyl myristate 1.5
Liquid paraffin 1.0
Polyethylene glycol monostearate (40EO) 3.0
Palm oil fatty acid sorbitan 2.0
Glycerol monostearate 1.0
Cetostearyl alcohol 1.0
Pantothenyl ethyl ether 0.5
Propylparaben 0.1
B water phase
N-Myristoylvalin 4.0
Ornithine 1.0
Polyethylene glycol 1540 1.0
Polyethylene glycol 1500 1.0
1,3-butylene glycol 2.5
Dipropylene glycol 2.5
Methylparaben 0.25
Clove extract 0.2
Purified water Remainder C: Fragrance Appropriate amount The above formulations A and B were dissolved at 70 ° C., and A was added to B to uniformly emulsify. Further, C was added while cooling to prepare a hair growth cream.

Example 13 (hair growth tonic)
6-Benzylaminopurine 0.5
Yukinoshita Extract 0.05
Isopropylmethylphenol 0.2
Polyethylene glycol 400 3.0
POE (40) hardened castor oil 0.2
Vinyl acetate / vinyl pyrrolidone copolymer 0.1
L-Menthol 0.1
Cha extract 1.0
Succinic acid 0.05
Ethanol 70
Purified water balance

Example 14 (Aerosol hair growth tonic)
(Stock solution)
Artemisia extract 0.05%
Pantotheniether 0.2
Soybean extract 0.02
Diglucosyl gallic acid 0.5
Stearyltrimethylammonium chloride (50% solution) 0.1
Polyethylene glycol 300 0.5
L-Menthol 0.5
Citric acid 0.05
Perfume appropriate amount ethanol 80
Purified water balance (propellant)
Dimethyl ether / nitrogen 30/1
(Stock solution / propellant) 85/15

  All the hair cosmetic compositions obtained in Examples 5 to 14 were excellent in the effect of preventing hair loss.

Claims (4)

  A hair follicle apoptosis reaction inhibitor characterized by containing an anti-inflammatory substance and an antioxidant substance.   Anti-inflammatory substances are glycyrrhetinic acid and / or its derivatives, glycyrrhizic acid and / or its salts, allantoin, aloe vera extract, altea extract, arnica extract, ginkgo biloba extract, ginger extract, ginseng extract, red ginger extract, chamomile extract, kawara mugwort extract, Kidney aloe extract, Gardenia extract, Kumazasa extract, Cape aloe extract, Linden bark extract, Birch bark extract, Horsetail extract, Euryoptera extract, Sage extract, Zeni mushroom extract, Assembly extract, Sakuhaku extract, Clove extract, Toki extract, Tokinsenka extract, Dokudami extract, Bukuryo extract, Loofah extract, safflower extract, batyl alcohol, mugwort extract, button extract, saxifrage extract, mugwort extract, Remokouekisu, aspirin, indomethacin, one or hair follicle apoptotic response inhibitor according to claim 1 is two or more selected from the group consisting of Ferunabiku. Antioxidants include Piroctone olamine, Ashitaba extract, Oolong tea extract, Turmeric extract, Ogon extract, Auren extract, Oryzanol, Rice bran fermented extract, Rice germ oil, Comfrey extract, Perilla extract, Peonies extract, Soy extract, Cha extract, Tocopherol, The hair follicle apoptosis according to claim 1 or 2, wherein the hair follicle apoptosis is one or more selected from the group consisting of tocotrienol, loquat leaf extract, horse chestnut extract, lactoferrin, lavender extract, rosemary extract, carotenoid, ascorbic acid, coenzyme Q10, and glutathione. Reaction inhibitor.   A hair cosmetic composition comprising the hair follicle apoptosis inhibitor of claims 1 to 3.