CN104958538A

CN104958538A - Traditional Chinese medicinal composition containing arctigenin, and preparation method thereof

Info

Publication number: CN104958538A
Application number: CN201510316519.5A
Authority: CN
Inventors: 杨磊
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-11
Filing date: 2015-06-11
Publication date: 2015-10-07
Also published as: WO2016197276A1

Abstract

The invention discloses a traditional Chinese medicinal composition containing arctigenin, and a preparation method thereof. The composition comprises 50-60 parts of arctigenin, 15-20 parts of Radix Ophiopogonis, 10-15 parts of Atractylodes lancea, 5-10 parts of Ligusticum wallichii, 5-10 parts of borneol, 5-10 parts of cinnamon, 5-10 parts of wolfberry fruit, 1-5 parts of Rhizoma Pinelliae Preparatum, 1-5 parts of Polygonatum odoratum, 1-5 parts of Malaytea Scurfpea Fruit, 5-10 parts of hawthorn fruit, 5-10 parts of Weeping Forsythia and 5-10 parts of honeysuckle flower. The composition is prepared through a supercritical extraction process. The composition is used for treating alopecia, has a good treatment effect, can promote hair generation, and has a total effective rate reaching above 95%. All raw materials used in the invention are convenient to draw, and are cheap, and the preparation method has the advantages of simple operation, low cost and easy industrialized production.

Description

A kind of Chinese medicine composition containing arctigenin and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine composition containing arctigenin and preparation method thereof.

Background technology

Alopecia is divided into seborrheic alopecia, androgenetic alopecia, psychogenic alopecia, dyscrinic alopecia, blood loss alopecia, alopecia of chemical origin, the dyskinetic alopecia of Nutrition and Metabolism, tinea capitis alopecia.Stress be excessively cause alopecia commonly encountered diseases because of.Psychentonia, melancholy, fear or serious insomnia etc. all can cause nervous dysfunction, and blood capillary continues to be in contraction state, and hair follicle can not get sufficient blood supply, and scalp is positioned at the top of human body, and thus hair the most easily comes off.Anemia, malnutrition, acute high fever, infectious disease or long-term hepatopathy, if disturb the function of root of hair portion hair follicle, then can affect growth and the color and luster of hair, even make hair follicle proper splitting suppressed, and make hair be in resting stage, there is alopecia.In prior art can anti-loss Chinese medicine formula more, but while control alopecia can also the Chinese medicine of hair growth promoting less.

Summary of the invention

The object of the present invention is to provide and a kind ofly prevent and treat alopecia and can Chinese medicine composition and preparation method thereof containing arctigenin of hair growth promoting, to solve the problem proposed in above-mentioned background technology.

For achieving the above object, the invention provides following technical scheme:

Containing the Chinese medicine composition of arctigenin, consist of the following composition: arctigenin 50-60 part, Radix Ophiopogonis 15-20 part, Rhizoma Atractylodis 10-15 part, Rhizoma Chuanxiong 5-10 part, Borneolum Syntheticum 5-10 part, Cortex Cinnamomi 5-10 part, Fructus Lycii 5-10 part, Rhizoma Pinelliae Preparatum 1-5 part, Rhizoma Polygonati Odorati 1-5 part, Fructus Psoraleae 1-5 part, Fructus Crataegi 5-10 part, Fructus Forsythiae 5-10 part, Flos Lonicerae 5-10 part.

As the further scheme of the present invention: the described Chinese medicine composition containing arctigenin, consists of the following composition: arctigenin 53-57 part, Radix Ophiopogonis 16-18 part, Rhizoma Atractylodis 12-14 part, Rhizoma Chuanxiong 7-9 part, Borneolum Syntheticum 7-9 part, Cortex Cinnamomi 7-9 part, Fructus Lycii 7-9 part, Rhizoma Pinelliae Preparatum 2-3 part, Rhizoma Polygonati Odorati 2-3 part, Fructus Psoraleae 2-3 part, Fructus Crataegi 7-9 part, Fructus Forsythiae 7-9 part, Flos Lonicerae 7-9 part.

As the further scheme of the present invention: the described Chinese medicine composition containing arctigenin, consists of the following composition: arctigenin 55 parts, Radix Ophiopogonis 17 parts, Rhizoma Atractylodis 13 parts, Rhizoma Chuanxiong 8 parts, Borneolum Syntheticum 8 parts, Cortex Cinnamomi 8 parts, Fructus Lycii 8 parts, Rhizoma Pinelliae Preparatum 2 parts, Rhizoma Polygonati Odorati 2 parts, Fructus Psoraleae 2 parts, Fructus Crataegi 8 parts, Fructus Forsythiae 8 parts, Flos Lonicerae 8 parts.

The preparation method of the described Chinese medicine composition containing arctigenin, adopt supercritical extraction, concrete steps comprise:

1) mixture of Radix Ophiopogonis, Rhizoma Atractylodis, Rhizoma Chuanxiong, Borneolum Syntheticum, Cortex Cinnamomi, Fructus Lycii, Rhizoma Pinelliae Preparatum, Rhizoma Polygonati Odorati, Fructus Psoraleae, Fructus Crataegi, Fructus Forsythiae, Flos Lonicerae is pulverized, cross 100-140 mesh sieve, be placed in extraction kettle to extract, extraction temperature is 80-90, extracting pressure is 5-10MPa, extraction time is 5-6h, collects volatile oil, obtains the extract of mixture;

2) in extract, put into arctigenin, be condensed into extractum after mix homogeneously, extractum is put into vacuum drying oven dry, obtain dry cream, baking temperature is 50-55 DEG C, and drying time is 24-36h;

3) dried cream powder is broken, add pharmaceutically acceptable adjuvant and be prepared into pharmaceutically conventional Chinese medicine composition.

As the further scheme of the present invention: be used for the treatment of alopecia.

The mechanism of action of each raw material in the present invention: it is active that arctiin has anti-cancer of pancreas, and one of its mechanism of action is cell death inducing.This product can cause vasodilation, blood pressure drops; Make cold-blooded and homoiothermic animal generation convulsions, heavy dose causes respiratory failure, and makes mouse skin rubescent, and diarrhoea, then suppresses it to isolated rabbit intestinal and uterus.Be paralysis effect to nervus motorius and skeleton, and the slight act end reaction of mice can be caused.

Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.

Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For retention of dampness in middle-JIAO, distension and fullness in the abdomen, has loose bowels, edema, and beriberi flaccidity is knitted, and rheumatic arthralgia, anemofrigid cold, nyctalopia, eyes dusk is puckery.

Ligustrazine energy coronary artery dilator in Rhizoma Chuanxiong, increases coronary artery blood flow, improves the blood oxygen supply of cardiac muscle, and reduces the oxygen consumption of cardiac muscle; The expansible cerebrovascular of ligustrazine, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation; Can surface activity of blood platelet be reduced, suppress platelet aggregation, the formation of pre-preventing thrombosis; The neutral compound low dose of contained ferulic acid promotes, heavy dose of suppression uterine smooth muscle; Water decoction has sedation to animal central nervous systems, and has obvious and lasting hypotensive effect; The absorption of fracture local hematoma can be accelerated, promote callus formation; There is the effect of vitamin antagonist E shortage; Multiple bacillus can be suppressed; There are antihistaminic and choleretic effect.

Borneolum Syntheticum delicate fragrance a surname is loose, has refreshment of having one's ideas straightened out, and the loose poison of heat clearing away, effect of improving acuity of vision and removing nebula, cures mainly calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, and heat-damp in summer hoodwinks key clearly, and sore throat is deaf, and aphtha tooth swells, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, pterygium

Cortex Cinnamomi has benefit fire supporing yang, guiding fire to origin, dispersing cold for relieving pain, effect of promoting the flow of QI-blood by warming the meridian.For sexual impotence cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, upward floating of YANG in deficiency condition, dizzy conjunctival congestion, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, and colic of cold type is suffered from abdominal pain, dysmenorrhea amenorrhea.

Fructus Lycii fruit, containing lycium barbarum polysaccharide, contains betanin (betaine), atropine, hyoscyamine again; Another zeaxanthine (zeaxanthin), Calyx seu fructus physalis red pigment (physalein), kryptoxanthin (cryptoxanthin), scopoletin (scopoletin), carotene, riboflavin, nicotinic acid, vitamin B1, B2 and the C. seed of containing is containing aminoacid: aspartic acid, proline, alanine, leucine etc.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For the sweet flat matter profit of syndrome of yin deficiency of liver and kidney this product, flat invigorating the liver and kidney, has strengthening by means of tonics effect, and all cards of all hepatic and renal YIN deficiency all can be applied.

Rhizoma Pinelliae Preparatum drying dampness to eliminate phlegm.For dry laryngopharynx, abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache.

The yin nourishing of Rhizoma Polygonati Odorati Rhizoma Polygonati Odorati tool, moisturize, heat clearing away, promote the production of body fluid, the effect such as cough-relieving.As tonic, cure mainly the diseases such as consumption of YIN caused by febrile disease, deficiency-heat cough caused by dryness, heart disease, diabetes, tuberculosis.

Fructus Psoraleae kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, lumbago due to renal deficiency, frequent micturition, bed-wetting, kidney leaks, warming spleen and stopping diarrha, helping inspiration to relieve asthma.Be used for the treatment of impotence due to deficiency of the kidney, soreness of the waist and knees cold type of pain, emission due to deficiency of the kidney, the enuresis, frequent micturition etc.Be used for the treatment of the Diarrhoea that deficiency of spleen-YANG and kidneyYANG causes.The deficiency and coldness being used for the treatment of failure of the kidney in receiving QI is breathed with cough.

Hawthorn digesting stomach invigorating, circulation of qi promoting dissipating blood stasis, changes turbid blood fat reducing.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, obstruction of qi in the chest and cardialgia, hernia pain, hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.

Fructus Forsythiae heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.

Flos Lonicerae property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.

Compared with prior art, the invention has the beneficial effects as follows: the present invention is used for the treatment of alopecia, therapeutic effect is good, and can promote hair growth promoting, and total effective rate reaches more than 95%.In the present invention, each raw material is drawn materials conveniently, and cheap, preparation process is easy and simple to handle, and cost is low, is easy to suitability for industrialized production.

Detailed description of the invention

Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.

Embodiment 1

In the embodiment of the present invention, a Chinese medicine composition containing arctigenin, consists of the following composition: arctigenin 50 parts, Radix Ophiopogonis 15 parts, Rhizoma Atractylodis 10 parts, Rhizoma Chuanxiong 5 parts, Borneolum Syntheticum 5 parts, Cortex Cinnamomi 5 parts, Fructus Lycii 5 parts, Rhizoma Pinelliae Preparatum 1 part, Rhizoma Polygonati Odorati 1 part, Fructus Psoraleae 1 part, Fructus Crataegi 5 parts, Fructus Forsythiae 5 parts, Flos Lonicerae 5 parts.

1) mixture of Radix Ophiopogonis, Rhizoma Atractylodis, Rhizoma Chuanxiong, Borneolum Syntheticum, Cortex Cinnamomi, Fructus Lycii, Rhizoma Pinelliae Preparatum, Rhizoma Polygonati Odorati, Fructus Psoraleae, Fructus Crataegi, Fructus Forsythiae, Flos Lonicerae is pulverized, cross 100-140 mesh sieve, be placed in extraction kettle to extract, extraction temperature is 80, extracting pressure is 10MPa, extraction time is 6h, collects volatile oil, obtains the extract of mixture;

2) in extract, put into arctigenin, be condensed into extractum after mix homogeneously, extractum is put into vacuum drying oven dry, obtain dry cream, baking temperature is 50 DEG C, and drying time is 36h;

Embodiment 2

In the embodiment of the present invention, a Chinese medicine composition containing arctigenin, consists of the following composition: arctigenin 60 parts, Radix Ophiopogonis 20 parts, Rhizoma Atractylodis 15 parts, Rhizoma Chuanxiong 10 parts, Borneolum Syntheticum 10 parts, Cortex Cinnamomi 10 parts, Fructus Lycii 10 parts, Rhizoma Pinelliae Preparatum 5 parts, Rhizoma Polygonati Odorati 5 parts, Fructus Psoraleae 5 parts, Fructus Crataegi 10 parts, Fructus Forsythiae 10 parts, Flos Lonicerae 10 parts.

1) mixture of Radix Ophiopogonis, Rhizoma Atractylodis, Rhizoma Chuanxiong, Borneolum Syntheticum, Cortex Cinnamomi, Fructus Lycii, Rhizoma Pinelliae Preparatum, Rhizoma Polygonati Odorati, Fructus Psoraleae, Fructus Crataegi, Fructus Forsythiae, Flos Lonicerae is pulverized, cross 100-140 mesh sieve, be placed in extraction kettle to extract, extraction temperature is 90, extracting pressure is 5MPa, extraction time is 5h, collects volatile oil, obtains the extract of mixture;

2) in extract, put into arctigenin, be condensed into extractum after mix homogeneously, extractum is put into vacuum drying oven dry, obtain dry cream, baking temperature is 55 DEG C, and drying time is 24h;

Embodiment 3

In the embodiment of the present invention, a Chinese medicine composition containing arctigenin, consists of the following composition: arctigenin 53 parts, Radix Ophiopogonis 16 parts, Rhizoma Atractylodis 12 parts, Rhizoma Chuanxiong 7 parts, Borneolum Syntheticum 7 parts, Cortex Cinnamomi 7 parts, Fructus Lycii 7 parts, Rhizoma Pinelliae Preparatum 2 parts, Rhizoma Polygonati Odorati 2 parts, Fructus Psoraleae 2 parts, Fructus Crataegi 7 parts, Fructus Forsythiae 7 parts, Flos Lonicerae 7 parts.

1) mixture of Radix Ophiopogonis, Rhizoma Atractylodis, Rhizoma Chuanxiong, Borneolum Syntheticum, Cortex Cinnamomi, Fructus Lycii, Rhizoma Pinelliae Preparatum, Rhizoma Polygonati Odorati, Fructus Psoraleae, Fructus Crataegi, Fructus Forsythiae, Flos Lonicerae is pulverized, cross 100-140 mesh sieve, be placed in extraction kettle to extract, extraction temperature is 82, extracting pressure is 6MPa, extraction time is 5.2h, collects volatile oil, obtains the extract of mixture;

2) in extract, put into arctigenin, be condensed into extractum after mix homogeneously, extractum is put into vacuum drying oven dry, obtain dry cream, baking temperature is 51 DEG C, and drying time is 25h;

Embodiment 4

In the embodiment of the present invention, a Chinese medicine composition containing arctigenin, consists of the following composition: arctigenin 57 parts, Radix Ophiopogonis 18 parts, Rhizoma Atractylodis 14 parts, Rhizoma Chuanxiong 9 parts, Borneolum Syntheticum 9 parts, Cortex Cinnamomi 9 parts, Fructus Lycii 9 parts, Rhizoma Pinelliae Preparatum 3 parts, Rhizoma Polygonati Odorati 3 parts, Fructus Psoraleae 3 parts, Fructus Crataegi 9 parts, Fructus Forsythiae 9 parts, Flos Lonicerae 9 parts.

1) mixture of Radix Ophiopogonis, Rhizoma Atractylodis, Rhizoma Chuanxiong, Borneolum Syntheticum, Cortex Cinnamomi, Fructus Lycii, Rhizoma Pinelliae Preparatum, Rhizoma Polygonati Odorati, Fructus Psoraleae, Fructus Crataegi, Fructus Forsythiae, Flos Lonicerae is pulverized, cross 100-140 mesh sieve, be placed in extraction kettle to extract, extraction temperature is 87, extracting pressure is 8MPa, extraction time is 5.7h, collects volatile oil, obtains the extract of mixture;

2) in extract, put into arctigenin, be condensed into extractum after mix homogeneously, extractum is put into vacuum drying oven dry, obtain dry cream, baking temperature is 54 DEG C, and drying time is 30h;

Embodiment 5

In the embodiment of the present invention, a Chinese medicine composition containing arctigenin, consists of the following composition: arctigenin 55 parts, Radix Ophiopogonis 17 parts, Rhizoma Atractylodis 13 parts, Rhizoma Chuanxiong 8 parts, Borneolum Syntheticum 8 parts, Cortex Cinnamomi 8 parts, Fructus Lycii 8 parts, Rhizoma Pinelliae Preparatum 2 parts, Rhizoma Polygonati Odorati 2 parts, Fructus Psoraleae 2 parts, Fructus Crataegi 8 parts, Fructus Forsythiae 8 parts, Flos Lonicerae 8 parts.

1) mixture of Radix Ophiopogonis, Rhizoma Atractylodis, Rhizoma Chuanxiong, Borneolum Syntheticum, Cortex Cinnamomi, Fructus Lycii, Rhizoma Pinelliae Preparatum, Rhizoma Polygonati Odorati, Fructus Psoraleae, Fructus Crataegi, Fructus Forsythiae, Flos Lonicerae is pulverized, cross 100-140 mesh sieve, be placed in extraction kettle to extract, extraction temperature is 85, extracting pressure is 7MPa, extraction time is 5.5h, collects volatile oil, obtains the extract of mixture;

2) in extract, put into arctigenin, be condensed into extractum after mix homogeneously, extractum is put into vacuum drying oven dry, obtain dry cream, baking temperature is 52 DEG C, and drying time is 30h;

Embodiment 6

The Chinese medicine composition obtained by above-described embodiment spreads upon the disease sites of the patient of alopecia symptom, is coated with 2 every day, and a course for the treatment of is 8 days, and the enforcement patient populations of each embodiment is 20.Patient is after the treatment through 2 courses for the treatment of, and the hair loss state of patient after observing, depilation phenomenon stops as effective example completely, and depilation phenomenon stops and having kainogenesis to go out, and is specially good effect example, calculates the quantity of effectively example and specially good effect example, as shown in table 1.

Table 1

	Specially good effect example	Effective example	Invalid example
				Embodiment 1	13	6	1
Embodiment 2	12	7	1
				Embodiment 3	16	4	0
Embodiment 4	17	3	0
				Embodiment 5	18	2	0

To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.

In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.

Claims

1. the Chinese medicine composition containing arctigenin, it is characterized in that, consist of the following composition: arctigenin 50-60 part, Radix Ophiopogonis 15-20 part, Rhizoma Atractylodis 10-15 part, Rhizoma Chuanxiong 5-10 part, Borneolum Syntheticum 5-10 part, Cortex Cinnamomi 5-10 part, Fructus Lycii 5-10 part, Rhizoma Pinelliae Preparatum 1-5 part, Rhizoma Polygonati Odorati 1-5 part, Fructus Psoraleae 1-5 part, Fructus Crataegi 5-10 part, Fructus Forsythiae 5-10 part, Flos Lonicerae 5-10 part.

2. the Chinese medicine composition containing arctigenin according to claim 1, it is characterized in that, consist of the following composition: arctigenin 53-57 part, Radix Ophiopogonis 16-18 part, Rhizoma Atractylodis 12-14 part, Rhizoma Chuanxiong 7-9 part, Borneolum Syntheticum 7-9 part, Cortex Cinnamomi 7-9 part, Fructus Lycii 7-9 part, Rhizoma Pinelliae Preparatum 2-3 part, Rhizoma Polygonati Odorati 2-3 part, Fructus Psoraleae 2-3 part, Fructus Crataegi 7-9 part, Fructus Forsythiae 7-9 part, Flos Lonicerae 7-9 part.

3. the Chinese medicine composition containing arctigenin according to claim 2, it is characterized in that, consist of the following composition: arctigenin 55 parts, Radix Ophiopogonis 17 parts, Rhizoma Atractylodis 13 parts, Rhizoma Chuanxiong 8 parts, Borneolum Syntheticum 8 parts, Cortex Cinnamomi 8 parts, Fructus Lycii 8 parts, Rhizoma Pinelliae Preparatum 2 parts, Rhizoma Polygonati Odorati 2 parts, Fructus Psoraleae 2 parts, Fructus Crataegi 8 parts, Fructus Forsythiae 8 parts, Flos Lonicerae 8 parts.

4. a preparation method for the Chinese medicine composition containing arctigenin as described in as arbitrary in claim 1-3, is characterized in that, adopt supercritical extraction, concrete steps comprise:

5., according to the arbitrary described Chinese medicine composition containing arctigenin of claim 1-3, it is characterized in that, be used for the treatment of alopecia.