CN103330756B - Drug for treating Raynaud disease and preparation method thereof - Google Patents
Drug for treating Raynaud disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a drug for treating the Raynaud disease and a preparation method thereof. The drug is mainly prepared from such drugs as white mustard seed, white paeony root, safflower, ephedrae, akebia stem, nacre and deer-horn glue according to a certain weight ratio. The drug has the functions of warming spleen and stomach for dispelling cold, activating blood to promote menstruation and removing stasis to stop pains and takes effect quickly and has good curative effects and high cure rate when being used for treating the Raynaud disease.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of raynaud disease and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Raynaud disease be a kind of chance cold or nervous after, with strong contraction of paroxysmal acra small artery, cause that acro-ischemia changes into the disease of feature, claim again acra vasospastic disease.During outbreak, acra skin becomes livid purplely from pale, then transfers flushing to.At present, western medicine raynaud disease poor effect, and have more side effect, therefore, there is very large demand to the Chinese medicine of rapid, effective treatment raynaud disease in people.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment raynaud disease, thereby has completed the present invention.
Object of the present invention is just to provide a kind of composition of medicine that can effectively treat raynaud disease.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Semen Sinapis Albae, Radix Paeoniae Alba, Hirudo, Ramulus Cinnamomi, Flos Carthami, the Radix Angelicae Dahuricae, Herba Ephedrae, Caulis Akebiae, Concha Margaritifera, Colla cornus cervi, the Radix Astragali, Herba Asari medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thus can fast treating Reynolds palindromia.Wherein select Semen Sinapis Albae to be because its nature and flavor are pungent, temperature, enters lung, stomach warp, has promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, and the function of removing obstruction in the collateral to relieve pain, controls phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation vomiting, aphasia due to apoplexy, limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Select Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Hirudo to be because the salty hardship of its nature and flavor is flat, poisonous, enter liver, urinary bladder channel, have removing blood stasis, removing blood stasis, the function of stimulating the menstrual flow, controls blood-retention ， mass in the abdomen, gathers, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, conjunctival congestion with ophthalmalgia, nebula.Selecting Ramulus Cinnamomi is that temperature, enters bladder, the heart, lung meridian, has diaphoresis expelling pathogenic factors from muscles because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select Flos Carthami to be because its nature and flavor are pungent, temperature, enters the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select the Radix Angelicae Dahuricae to be because its nature and flavor are pungent, temperature, enters lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Herba Ephedrae to be because its nature and flavor are arduous, temperature, enters lung, urinary bladder channel, has diaphoresis, relievings asthma, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Select Caulis Akebiae to be because its nature and flavor are bitter, cool, enter the heart, small intestinal, urinary bladder channel, have pathogenic fire purging row water, the function of promoting blood circulation, controls hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Select Concha Margaritifera to be because its nature and flavor are salty, cool, enter the heart, liver two warps, have suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, the function of hemostasis, controls dizziness, tinnitus, cardiopalmus, insomnia, demented ， Jing Epilepsy, spits blood, epistaxis, metrorrhagia.Selecting Colla cornus cervi is that temperature, enters liver, kidney channel because of its property sweet-salty, enriches blood, and the function of benefit essence, controls deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, uterus cold caused by deficiency, metrorrhagia, leukorrhagia.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enters lung, spleen channel, raw with the useful consolidating superficial resistance of defending, inducing diuresis to remove edema, and poison holding, the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and hold back for a long time; Process by the function that has invigorating middle warmer benefit, control internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Herba Asari to be because its nature and flavor are pungent, temperature, enters lung, kidney channel, dispel the wind, and cold expelling, row water, the function of having one's ideas straightened out, controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Semen Sinapis Albae 8-12 gram of Radix Paeoniae Alba 10-20 gram of Hirudo 5-10 gram
Ramulus Cinnamomi 8-12 gram of Flos Carthami 6-10 gram of Radix Angelicae Dahuricae 8-12 gram
Herba Ephedrae 6-10 gram of Caulis Akebiae 10-15 gram of Concha Margaritifera 8-12 gram
Colla cornus cervi 6-10 gram of Radix Astragali 10-20 gram of Herba Asari 10-15 gram
Preferable amount is
6 grams of 15 grams of Hirudos of 10 grams of Radix Paeoniae Alba of Semen Sinapis Albae
10 grams of 8 grams of Radixs Angelicae Dahuricae of 10 grams of Flos Carthamis of Ramulus Cinnamomi
10 grams of 12 grams of Concha Margaritiferas of 8 grams of Caulis Akebiaes of Herba Ephedrae
12 grams of 15 grams of Herba Asaris of 8 grams of Radixs Astragali of Colla cornus cervi
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, micro-have fragrance and get final product;
2, Radix Paeoniae Alba: choose decontamination, size separately, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
3, Hirudo: clean, vexed soft, cutting, dries;
4, Ramulus Cinnamomi: water slightly soaks, pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;
5, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
6, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
7, Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after micro-profit, is drying to obtain;
8, Caulis Akebiae: water slightly soaks, moistening, to thoroughly, is cut into slices, and dries;
9, Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;
10, Colla cornus cervi: get crude drug, remove impurity, the used time smashs to pieces or levigation;
11, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
12, Herba Asari: Ex-all impurity, water spray profit, cutting in time, dries.
Two, preparation
1, the Semen Sinapis Albae of described weight, Radix Paeoniae Alba, Hirudo, Ramulus Cinnamomi, Flos Carthami, the Radix Angelicae Dahuricae, Herba Ephedrae, Caulis Akebiae, Concha Margaritifera, Colla cornus cervi, the Radix Astragali, Herba Asari medicine being added to 6 times of water gagings soaks, soak after 100 minutes, intense fire decocts boiling 10 minutes, with slow fire boiling, within 20 minutes, filter, decoction liquor is poured in container for the first time again.
2, add for the second time 3 times of amounts of water, intense fire decocts boiling 10 minutes, then within 20 minutes, filters with slow fire boiling, obtains decoction liquor for the second time.
3, by twice decoction liquor mixing and stirring, intense fire boils, then uses slow fire boiling 10 minutes, decoction liquor is divided into 3 doses and takes.
Medicine of the present invention has warming spleen and stomach for dispelling cold, promoting blood circulation to restore menstrual flow, and the function of blood stasis removing pain relieving, is used for the treatment of raynaud disease, short treating period, instant effect, non-relapse after healing, has no side effect.
The specific embodiment
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, male and female dual-purpose, body weight 2.2-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy raynaud disease of the present invention
1, physical data
Accept out-patient's totally 110 examples for medical treatment, its male patient's 70 examples, female patient 40 examples.
2, diagnostic criteria
The typical episode process of raynaud disease is for when cold stimulation or excited and psychentonia, and pale and cyanosis appears in finger skin, and finger tip has numbness, sends out cool and twinge, after warming, color of the leather becomes flushing, has warm and swollen sense, then color of the leather recovers normal, and symptom also disappears thereupon.Disease is early stage, and above-mentioned variation frequently showed effect in cold season, and symptom is obvious, and the persistent period is long, on the contrary warm season.As heavier in the state of an illness, all can frequently show effect throughout the year.
Color of the leather changes often regular, and the finger of getting involved is often symmetry, and color of the leather changes and how by the 4th, 5,3 and 2 fingers, sequentially to develop, thumb is seldom got involved compared with abundant because of the more blood supply of muscle, color of the leather changes first and starts gradually upwards development from minor details, but seldom surpasses wrist, all occurs in both hands.The phenomenon of toes generation raynaud disease is more rare, and auricle, nose, lip palor or cyanosis person are accidental.
Some patient lacks typical intermittent color of the leather and changes, and especially late, only has pale or cyanosis during outbreak.Severe patient finger tip skin occurs that malnutrition is as xerosis cutis, amyotrophy, fingernail embrittlement, all easy infections of first, after referring to stricture of artery or obturation, finger tip occurs shallow in ulcer and small size gangrene, and companion has an intense pain, and leaves over point-like cicatrix of skin after ulcer healing.
Raynaud disease patient has autonomic nervous dysfunction's symptom more, as inflammable, suspicious, gloomy in easy excitement, emotion, insomnia and dreamful sleep etc.Raynaud disease is without other General Symptomies, Raynaud phenomenon can be simultaneously with the clinical manifestation of protopathy.
Raynaud disease can make little vascular occlusion, causes finger tip ischemic necrosis.Severe patient can occur referring to that end refers to that abdomen flattens, gangrene, and phalangette can be downright bad because of ischemia, be absorbed, dissolve, and occurring shortening or cutting refers to phenomenon.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day early, respectively take 1 evening, within 15 days, is a course for the treatment of, takes continuously 3 courses for the treatment of.
4, efficacy assessment standard
Effective: transference cure, it is normal that body constitution is recovered, and observes half a year without recidivist;
Take a turn for the better: shape is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy raynaud disease patient of the present invention 110 examples, effective 102 examples of result, obvious effective rate is 92.73%, 5 examples that take a turn for the better, and improvement rate is 4.55%, invalid 3 examples, total effective rate is 97.28%.
Claims (3)
1. a medicine for the treatment of raynaud disease, is characterized in that: it is to be made by the crude drug in following weight range:
Semen Sinapis Albae 8-12 gram of Radix Paeoniae Alba 10-20 gram of Hirudo 5-10 gram
Ramulus Cinnamomi 8-12 gram of Flos Carthami 6-10 gram of Radix Angelicae Dahuricae 8-12 gram
Herba Ephedrae 6-10 gram of Caulis Akebiae 10-15 gram of Concha Margaritifera 8-12 gram
Colla cornus cervi 6-10 gram of Radix Astragali 10-20 gram of Herba Asari 10-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
6 grams of 15 grams of Hirudos of 10 grams of Radix Paeoniae Alba of Semen Sinapis Albae
10 grams of 8 grams of Radixs Angelicae Dahuricae of 10 grams of Flos Carthamis of Ramulus Cinnamomi
10 grams of 12 grams of Concha Margaritiferas of 8 grams of Caulis Akebiaes of Herba Ephedrae
12 grams of 15 grams of Herba Asaris of 8 grams of Radixs Astragali of Colla cornus cervi.
3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, micro-have fragrance and get final product;
(2) Radix Paeoniae Alba: choose decontamination, size separately, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(3) Hirudo: clean, vexed soft, cutting, dries;
(4) Ramulus Cinnamomi: water slightly soaks, pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;
(5) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(6) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
(7) Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after micro-profit, is drying to obtain;
(8) Caulis Akebiae: water slightly soaks, moistening, to thoroughly, is cut into slices, and dries;
(9) Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;
(10) Colla cornus cervi: get crude drug, remove impurity, the used time smashs to pieces or levigation;
(11) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(12) Herba Asari: Ex-all impurity, water spray profit, cutting in time, dries;
(2) preparation
(1) Semen Sinapis Albae of described weight, Radix Paeoniae Alba, Hirudo, Ramulus Cinnamomi, Flos Carthami, the Radix Angelicae Dahuricae, Herba Ephedrae, Caulis Akebiae, Concha Margaritifera, Colla cornus cervi, the Radix Astragali, Herba Asari medicine being added to 6 times of water gagings soaks, soak after 100 minutes, intense fire decocts boiling 10 minutes, with slow fire boiling, within 20 minutes, filter, decoction liquor is poured in container for the first time again;
(2) add for the second time 3 times of amounts of water, intense fire decocts boiling 10 minutes, then within 20 minutes, filters with slow fire boiling, obtains decoction liquor for the second time;
(3) by twice decoction liquor mixing and stirring, intense fire boils, then with slow fire boiling 10 minutes and get final product.
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| CN105267899A (en) * | 2014-06-19 | 2016-01-27 | 蒋世芬 | Traditional Chinese medicine mixed medicine used for treating Reynolds disease |
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| CN102357240A (en) * | 2011-10-22 | 2012-02-22 | 宋涛 | Traditional Chinese medicine for treating peripheral vascular functional disease of Raynaud disease |
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