CN103330756A - Drug for treating Raynaud disease and preparation method thereof - Google Patents
Drug for treating Raynaud disease and preparation method thereof Download PDFInfo
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- CN103330756A CN103330756A CN2013102575009A CN201310257500A CN103330756A CN 103330756 A CN103330756 A CN 103330756A CN 2013102575009 A CN2013102575009 A CN 2013102575009A CN 201310257500 A CN201310257500 A CN 201310257500A CN 103330756 A CN103330756 A CN 103330756A
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Abstract
The invention discloses a drug for treating the Raynaud disease and a preparation method thereof. The drug is mainly prepared from such drugs as white mustard seed, white paeony root, safflower, ephedrae, akebia stem, nacre and deer-horn glue according to a certain weight ratio. The drug has the functions of warming spleen and stomach for dispelling cold, activating blood to promote menstruation and removing stasis to stop pains and takes effect quickly and has good curative effects and high cure rate when being used for treating the Raynaud disease.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of raynaud disease and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Raynaud disease be a kind of chance cold or nervous after, cause that with strong contraction of paroxysmal acra small artery acro-ischemia changes into the disease of feature, claim the acra vasospastic disease again.During outbreak, acra skin becomes livid purplely by pale, then transfers flushing to.At present, western medicine raynaud disease poor effect, and more side effect is arranged, therefore, there is very big demand in people to the Chinese medicine of effectively treating raynaud disease fast.
Summary of the invention
The inventor has found the medicine of effective treatment raynaud disease finally, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
Purpose of the present invention just provides a kind of composition of medicine that can effectively treat raynaud disease.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicine of the present invention selects for use Semen Sinapis Albae, Radix Paeoniae Alba, Hirudo, Ramulus Cinnamomi, Flos Carthami, the Radix Angelicae Dahuricae, Herba Ephedrae, Caulis Akebiae, Concha Margaritifera, Colla cornus cervi, the Radix Astragali, Herba Asari medicine to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can treat the Reynolds palindromia fast.Wherein selecting Semen Sinapis Albae for use is that temperature is gone into lung, stomach warp, and the promoting the circulation of QI eliminating phlegm is arranged because of its nature and flavor suffering, warming spleen and stomach for dispelling cold, and the function of removing obstruction in the collateral to relieve pain is controlled the phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation vomiting, aphasia due to apoplexy, limbs arthralgia pain numbness, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Selecting Radix Paeoniae Alba for use is that liver, spleen channel are gone in cold, and nourishing blood to suppress the hyperactive liver is arranged because of its nature and flavor picric acid, slow middle pain relieving, and yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select for use Hirudo to be because the salty hardship of its nature and flavor is flat, poisonous, go into liver, urinary bladder channel, removing blood stasis is arranged, removing blood stasis, the function of stimulating the menstrual flow is controlled blood-retention ， mass in the abdomen, gathers, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, conjunctival congestion with ophthalmalgia, nebula.Selecting Ramulus Cinnamomi for use is that temperature is gone into bladder, the heart, lung meridian, and the diaphoresis expelling pathogenic factors from muscles is arranged because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation is controlled exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Selecting Flos Carthami for use is that temperature is gone into the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged because of its nature and flavor suffering, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Selecting the Radix Angelicae Dahuricae for use is that temperature is gone into lung, spleen, stomach warp because of its nature and flavor suffering, dispel the wind, and dampness, detumescence, the function of pain relieving is controlled headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select for use Herba Ephedrae to be because its nature and flavor are arduous, temperature is gone into lung, urinary bladder channel, and diaphoresis is arranged, and relievings asthma, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Selecting Caulis Akebiae for use is that the heart, small intestinal, urinary bladder channel are gone in cold, and pathogenic fire purging row water is arranged because of its nature and flavor hardship, and the function of promoting blood circulation is controlled hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Select for use Concha Margaritifera to be because its nature and flavor are salty, the heart, liver two warps are gone in cold, and suppressing the hyperactive liver is arranged, YANG hyperactivity suppressing, and arresting convulsion, the function of hemostasis is controlled dizziness, tinnitus, cardiopalmus, insomnia, demented ， Jing Epilepsy is spitted blood epistaxis, metrorrhagia.Selecting Colla cornus cervi for use is that temperature is gone into liver, kidney channel because of its property sweet-salty, enriches blood, and the function that benefit is smart is controlled deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, women's deficiency-cold of uterus, metrorrhagia, leukorrhagia.Select for use the Radix Astragali to be because its nature and flavor are sweet, tepor is gone into lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting is controlled spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and hold back for a long time; Process with the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Selecting Herba Asari for use is that temperature is gone into lung, kidney channel because of its nature and flavor suffering, dispel the wind, and cold expelling, row water, the function of having one's ideas straightened out is controlled air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in the following weight scope
Semen Sinapis Albae 8-12 gram Radix Paeoniae Alba 10-20 gram Hirudo 5-10 gram
Ramulus Cinnamomi 8-12 gram Flos Carthami 6-10 gram Radix Angelicae Dahuricae 8-12 gram
Herba Ephedrae 6-10 gram Caulis Akebiae 10-15 gram Concha Margaritifera 8-12 gram
Colla cornus cervi 6-10 gram Radix Astragali 10-20 gram Herba Asari 10-15 gram
Preferable amount is
Semen Sinapis Albae 10 gram Radix Paeoniae Alba 15 gram Hirudos 6 grams
The Ramulus Cinnamomi 10 gram Flos Carthamis 8 gram Radixs Angelicae Dahuricae 10 grams
Herba Ephedrae 8 gram Caulis Akebiaes 12 gram Concha Margaritiferas 10 grams
The Colla cornus cervi 8 gram Radixs Astragali 15 gram Herba Asaris 12 grams
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, little have fragrance namely;
2, Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
3, Hirudo: clean, vexed soft, cutting is dried;
4, Ramulus Cinnamomi: water soaks slightly, pulls out, and moistening is to saturating, and section is dried, and sieves anti-dandruff;
5, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
6, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine when not having soapy feeling to crust, again behind the moistening, chip drying;
7, Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, little profit back cutting is drying to obtain;
8, Caulis Akebiae: water soaks slightly, and moistening is to saturating, and section is dried;
9, Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;
10, Colla cornus cervi: get crude drug, remove impurity, the time spent smashs to pieces or levigation;
11, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through back section in time, dry;
12, Herba Asari: Ex-all impurity, water spray profit, cutting is in time dried.
Two, preparation
1, Semen Sinapis Albae, Radix Paeoniae Alba, Hirudo, Ramulus Cinnamomi, Flos Carthami, the Radix Angelicae Dahuricae, Herba Ephedrae, Caulis Akebiae, Concha Margaritifera, Colla cornus cervi, the Radix Astragali, the Herba Asari medicine of described weight being added 6 times of water gagings soaks, soak after 100 minutes, intense fire decocts boiling 10 minutes, filtered in 20 minutes with slow fire boiling, decoction liquor is poured in the container for the first time again.
2, add 3 times of amounts of water for the second time, intense fire decocts boiling 10 minutes, filters in 20 minutes with slow fire boiling again, gets decoction liquor for the second time.
3, with twice decoction liquor mixing and stirring, intense fire boils, and uses slow fire boiling again 10 minutes, decoction liquor is divided into 3 doses takes.
Medicine of the present invention has warming spleen and stomach for dispelling cold, promoting blood circulation to restore menstrual flow, and the function of blood stasis removing pain relieving is used for the treatment of raynaud disease, short treating period, instant effect, non-relapse after healing, has no side effect.
The specific embodiment
Below further sets forth the beneficial effect of medicine of the present invention by testing example, these are tested the routine animal toxicity test of medicine of the present invention that comprised and report and clinical observation material.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, the male and female dual-purpose, body weight 2.2-2.5kg divides two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day 2 times, observes administration reaction every day, and the result shows that two groups of rabbit activities, diet are normal, and medicine does not have bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy raynaud disease of the present invention
1, physical data
Accept out-patient's totally 110 examples for medical treatment, its male patient's 70 examples, female patient 40 examples.
2, diagnostic criteria
The typical episode process of raynaud disease is for when cold stimulation or excited and psychentonia, and pale and cyanosis appears in finger skin, and the finger tip has numbness, sends out cold and twinge, after warming, color of the leather becomes flushing, and warm and bloated sense is then arranged, then color of the leather recovers normal, and symptom also disappears thereupon.Disease is early stage, and above-mentioned variation frequently showed effect in cold season, and symptom is obvious, longer duration, otherwise warm season then.Heavier as the state of an illness, then all can frequently show effect throughout the year.
Color of the leather changes often regular, and the finger of getting involved often is symmetry, and color of the leather changes and how to develop in proper order by the 4th, 5,3 and 2 fingers, thumb is seldom got involved because the more blood supply of muscle is abundant, color of the leather changes earlier and begins gradually upwards development from minor details, but seldom surpasses wrist, all occurs in both hands.The phenomenon of toes generation raynaud disease is more rare, and auricle, nose, lip palor or cyanosis person are accidental.
Some patient lacks typical intermittent color of the leather and changes, and especially late, pale or cyanosis is only arranged during outbreak.Malnutrition such as xerosis cutis, amyotrophy, fingernail embrittlement, first week easy infection appears in severe patient finger tip skin, after referring to stricture of artery or obturation, it is shallow in ulcer and small size gangrene that finger tip occurs, and the companion has an intense pain, and leaves over the point-like cicatrix of skin behind the ulcer healing.
Raynaud disease patient has autonomic nervous dysfunction's symptom more,, insomnia and dreamful sleep inflammable, suspicious, gloomy as easy excitement, emotion etc.Raynaud disease does not have other General Symptomies, Raynaud phenomenon can be simultaneously with the clinical manifestation of protopathy.
Raynaud disease can make little vascular occlusion, causes the finger tip ischemic necrosis.Severe patient can occur referring to that end refers to that abdomen flattens, gangrene, and phalangette can be downright bad because of ischemia, be absorbed, dissolve, and occurring shortening or cutting refers to phenomenon.
3, Therapeutic Method
Select above-mentioned medicament for use, take to the patient, take 1 dose at every turn, every day early, respectively obey 1 time evening, 15 days is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Produce effects: transference cure, body constitution recover normal, observe and do not have the recidivist half a year;
Take a turn for the better: shape is clearly better, and body constitution is progressively recovered;
Invalid: as not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, with Drug therapy raynaud disease patient 110 examples of the present invention, produce effects 102 examples as a result, obvious effective rate is 92.73%, 5 examples that take a turn for the better, improvement rate is 4.55%, invalid 3 examples, total effective rate is 97.28%.
Claims (3)
1. medicine for the treatment of raynaud disease, it is characterized in that: it is to be made by the crude drug in the following weight range:
Semen Sinapis Albae 8-12 gram Radix Paeoniae Alba 10-20 gram Hirudo 5-10 gram
Ramulus Cinnamomi 8-12 gram Flos Carthami 6-10 gram Radix Angelicae Dahuricae 8-12 gram
Herba Ephedrae 6-10 gram Caulis Akebiae 10-15 gram Concha Margaritifera 8-12 gram
Colla cornus cervi 6-10 gram Radix Astragali 10-20 gram Herba Asari 10-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Semen Sinapis Albae 10 gram Radix Paeoniae Alba 15 gram Hirudos 6 grams
The Ramulus Cinnamomi 10 gram Flos Carthamis 8 gram Radixs Angelicae Dahuricae 10 grams
Herba Ephedrae 8 gram Caulis Akebiaes 12 gram Concha Margaritiferas 10 grams
The Colla cornus cervi 8 gram Radixs Astragali 15 gram Herba Asaris 12 grams.
3. according to the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
(1) gets the raw materials ready
(1) Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, little have fragrance namely;
(2) Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
(3) Hirudo: clean, vexed soft, cutting is dried;
(4) Ramulus Cinnamomi: water soaks slightly, pulls out, and moistening is to saturating, and section is dried, and sieves anti-dandruff;
(5) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(6) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine when not having soapy feeling to crust, again behind the moistening, chip drying;
(7) Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, little profit back cutting is drying to obtain;
(8) Caulis Akebiae: water soaks slightly, and moistening is to saturating, and section is dried;
(9) Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;
(10) Colla cornus cervi: get crude drug, remove impurity, the time spent smashs to pieces or levigation;
(11) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through back section in time, dry;
(12) Herba Asari: Ex-all impurity, water spray profit, cutting is in time dried;
(2) preparation
(1) Semen Sinapis Albae, Radix Paeoniae Alba, Hirudo, Ramulus Cinnamomi, Flos Carthami, the Radix Angelicae Dahuricae, Herba Ephedrae, Caulis Akebiae, Concha Margaritifera, Colla cornus cervi, the Radix Astragali, the Herba Asari medicine of described weight being added 6 times of water gagings soaks, soak after 100 minutes, intense fire decocts boiling 10 minutes, filtered in 20 minutes with slow fire boiling, decoction liquor is poured in the container for the first time again;
(2) add 3 times of amounts of water for the second time, intense fire decocts boiling 10 minutes, filters in 20 minutes with slow fire boiling again, gets decoction liquor for the second time;
(3) with twice decoction liquor mixing and stirring, intense fire boils, and uses slow fire boiling again 10 minutes, decoction liquor is divided into 3 doses takes.
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| CN201310257500.9A CN103330756B (en) | 2013-06-26 | 2013-06-26 | Drug for treating Raynaud disease and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267899A (en) * | 2014-06-19 | 2016-01-27 | 蒋世芬 | Traditional Chinese medicine mixed medicine used for treating Reynolds disease |
| CN105561272A (en) * | 2016-01-27 | 2016-05-11 | 赵俊 | Traditional Chinese medicine preparation for relieving Reynolds disease and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269141A (en) * | 2008-05-08 | 2008-09-24 | 北京天科仁祥医药科技有限公司 | Chinese medicinal composition for treating raynaud's disease and preparation method thereof |
| CN102357240A (en) * | 2011-10-22 | 2012-02-22 | 宋涛 | Traditional Chinese medicine for treating peripheral vascular functional disease of Raynaud disease |
-
2013
- 2013-06-26 CN CN201310257500.9A patent/CN103330756B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269141A (en) * | 2008-05-08 | 2008-09-24 | 北京天科仁祥医药科技有限公司 | Chinese medicinal composition for treating raynaud's disease and preparation method thereof |
| CN102357240A (en) * | 2011-10-22 | 2012-02-22 | 宋涛 | Traditional Chinese medicine for treating peripheral vascular functional disease of Raynaud disease |
Non-Patent Citations (1)
| Title |
|---|
| 洪培良: "中医药治疗雷诺病进展", 《陕西中医学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267899A (en) * | 2014-06-19 | 2016-01-27 | 蒋世芬 | Traditional Chinese medicine mixed medicine used for treating Reynolds disease |
| CN105561272A (en) * | 2016-01-27 | 2016-05-11 | 赵俊 | Traditional Chinese medicine preparation for relieving Reynolds disease and preparation method thereof |
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| CN103330756B (en) | 2014-05-07 |
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