CN101269141A - Chinese medicinal composition for treating raynaud's disease and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for curing Raynaud disease. The traditional Chinese medicine composition is made of milk veteh, salvia miltiorrhiza, dogwood, cassia twigs, rhizoma ligustici wallichii, root-bark of tree peony, red paeonia, bitter orange, fumitory, safflower, angelica, lumbricus, radix codonopsitis, dandelion, forsythia, honeysuckle and/or a carrier acceptable medically. The invention also relates to a preparation method for the traditional Chinese medicine composition. The traditional Chinese medicine composition has the functions of warming yang and dispersing cold, getting through blood vessels, invigorating Qin and regulating blood and warming meridians, inducing Bi syndrome, etc., and is used for curing disease symptoms such as limbs acral intermittent paleness, purplish red and flush caused by the Raynaud disease.

Description

A kind of Chinese medicine composition for the treatment of raynaud disease and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of raynaud disease and preparation method thereof.

Background technology

Raynaud disease claims again " Raynaud's disease ", is the acra arteriolospasm disease that a kind of nervus vasculairs dysfunction causes.Pale, purplish red and flushing is a main clinical characteristics with paroxysmal extremity acra intermittence, sees with the finger finger tip more, and is symmetry.The good women who sends out between 20～30 years old, and frequent cold season or the outbreak of excited, nervous or overtired back, the state of an illness increases the weight of.Still indeterminate at present for the paathogenic factor that causes primary disease.It is generally acknowledged relevantly with endocrine function, nervus centralis functional disorder, inherited genetic factors etc., modern western medicine does not still have gratifying Therapeutic Method at present.

Patient Chang Yin catches cold or points contact and show effect behind the low temperature, and psychentonia and the person of bringing out are also arranged because of excited.The feature in its when outbreak is meant that (toe) portion skin color bleaches suddenly, becomes livid purplely then, transfers flushing then to, is intermittent attack.See and toes are rare to point more.Outbreak is often from little finger of toe and the beginning of fourth finger point, and along with lesion growth extends to whole finger even metacarpus gradually, but the less morbidity of thumb is sent out bloated uncomfortable or other abnormal sensories of cold, numbness, twinge and acid with the part.Reduction is arranged when whole body and local temperature, but radial artery or dorsal artery of foot are beaten normally.When just sending out, it is spontaneous remission that duration of seizure mostly is about several minutes to half an hour.When skin transfers flushing to, often, transfer normal color and luster then to burning sensation of pricking.If local warming when outbreak rubs to wipe and suffers from limb, brandish limbs etc., outbreak is ended.Sx during disease progression, outbreak is frequent, and to show effect sustainable more than one hour at every turn, brothers need be immersed sometimes and could end outbreak in the warm water.

Paresthesia epilepsy is pair one key character that symmetry is a Raynaud syndrome.For example the both sides little finger of toe and the third finger are often got involved at first, prolong then and forefinger and middle finger.Thumb then seldom involves for abundant because of blood.The degree of both sides finger skin color change, scope also are identical.The a few patients initial onset is one-sided, transfers both sides later on to.

The course of disease is generally made slow progress, and a few patients makes fast progress, outbreak is frequent, serious symptom, with referring to (toe) swelling, each outbreak continued more than 1 hour, ambient temperature reduces slightly, emotion is slightly exciting just can bring out.Even serious warm season symptom do not disappear yet, refer to that (toe) brings out existing trophism and change, as the embrittlement of fingernail deformity, batch pad atrophy, skin light is thin, wrinkle disappears, first finger tip ulcer gangrene occasionally.But radial artery is not seen all the time and is weakened.

The prevention of this disease mainly comprises avoids cold stimulation and excited; Taboo smoking; Avoid using Ergotamine, beta-blocker and contraceptive; Person due to the obvious professional reason (operation under life-time service vibratility instrument, the low temperature) changes the I kind as far as possible.Careful protection finger is avoided wound, because of slight damage causes finger tip ulcer or other trophism pathological changes easily.The a small amount of inebriant of drink can improve symptom in the daily life.Can migrate as the condition permission person and to have a moderate climate, paresthesia epilepsy more can be reduced in dry area.Remove patient and worry mentally, keeping pleasant all is important measures in the prevention.

The traditional Chinese medical science thinks that raynaud disease belongs to categories such as " extremity cold of the limbs ", " arthralgia due to stagnation of blood ".In some classical traditional Chinese medical science books, can see the record similar, say as " element ask five hide generate " piece of writing with primary disease: " crouch out and wind it, the coagulation of blood in skin giving rise to numbness." mention exogenous wind first, blood stasis is the etiology and pathogenesis of primary disease.Afterwards treatise on Febrile Diseases is mentioned: " brothers faint cold, the thready pulse being about to disappear person, the danggui sini decoction master it." open the treatment primary disease the beginning." General Treatise on the Cause and Symptoms of Diseases " and then point out: " passages through which vital energy circulates draws and all arises from brothers, and asthenia is the vim and vigour damage that declines then, can not its extremity of temperature, so the extremity cold of the limbs is also.”

The traditional Chinese medical science think the primary disease cause of disease main with extraneous weather cold, qi-blood disharmony, visceral dysfunction is relevant, its pathogenesis is mainly as follows:

Deficiency of vital energy blood is puckery: natural endowment deficiency, so that internal organs QI and blood biochemical function void declines, the deficiency of vital energy is difficult to transport blood, the hyperamization arteries and veins is popular not smooth, the retardance of network road, refer to (toe) skin lose warm in QI and blood, moisten and support and numb, color of the leather loses color, and refers to that (toe) end sends out cool.

Deficiency of spleen-YANG and kidneyYANG: innate deficiency of YANG in the body, or prolonged illness consumption impairment of QI sun, or the cold-evil crouches for a long time, or have loose bowels with the passing of time, so that deficiency of spleen-YANG and kidneyYANG, deficiency of spleen-YANG then essence of water and grainization are given birth to unablely, are difficult to the kidney yang of supplementing nutrition.

Kidney yang decline then can not on rise warm spleen sun, and it is chilly to cause extremity, refers to that (toe) color of the leather is white as the wax shape, cold physique is extraneous whenever cold and symptom is aggravated.

Qi depression to blood stasis: excited or angryly be indignant, psychentonia etc., make mechanism of qi disorderly contrary, irritability stasis, catharsis mistake department, hematogenous blockage, the yang-energy extremity of can not leading to, or inhale relation by marriage for a long time, year or being invaded by exogenous pathogen cause acra channels oxygen content and reduce the cold coagulation channels, the unable promotion blood of yang-energy, coagulation of QI-blood can not replenishing vital QI with drugs of warm nature four ends, form primary disease.

Evil heat-transformation for a long time: with the passing of time the state of an illness delays, or mistake is controlled, wrong treatment, so that disease is invaded people's channels for a long time, stops up the retardance of crouching, accumulate strongly fragrant for a long time and heat-transformation, or pungent the processing of surfeit present a gift to a bereaved family, have a liking for tobacco and wine, or excess of sexual intercourse, meet exopathogen again, so that the pathogenic heat knot of fighting intercepts passages through which vital energy circulates, QI and blood stasis of blood plug causes acra local organization ischemic necrosis.

The traditional Chinese medical science adopts this disease of decoction for the treatment of warming YANG to expel cold, a surname's promoting blood circulation, QI invigorating and blood regulating, warming the meridian blood stasis dispelling.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of raynaud disease.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of raynaud disease, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Radix Astragali 5-10 part Radix Salviae Miltiorrhizae 5-15 part Fructus Corni 10-25 part

Ramulus Cinnamomi 10-20 part Rhizoma Chuanxiong 10-15 part Cortex Moutan 15-20 part

Radix Paeoniae Rubra 10-15 part Fructus Aurantii 10-20 part Rhizoma Corydalis 20-30 part

Flos Carthami 20-30 part Radix Angelicae Sinensis 15-25 part Pheretima 10-20 part

Radix Codonopsis 10-25 part Herba Taraxaci 15-25 part Fructus Forsythiae 25-30 part

Flos Lonicerae 20-30 part

Effective ingredient is preferably made by weight by following raw materials according:

18 parts of 10 parts of Fructus Corni of 8 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali

17 parts of 13 parts of Cortex Moutans of 16 parts of Rhizoma Chuanxiongs of Ramulus Cinnamomi

25 parts of 16 parts of Rhizoma Corydalis of 13 parts of Fructus Aurantiis of Radix Paeoniae Rubra

16 parts of 21 parts of Pheretimas of 25 parts of Radix Angelicae Sinensis of Flos Carthami

28 parts of 21 parts of Fructus Forsythiaes of 18 parts of Herba Taraxacis of Radix Codonopsis

26 parts of Flos Loniceraes

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) to be broken into impalpable powder standby for Radix Salviae Miltiorrhizae powder;

(2) Flos Lonicerae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Herba Taraxaci are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Astragali, Fructus Corni, Ramulus Cinnamomi, Cortex Moutan, Fructus Aurantii, Rhizoma Corydalis, Flos Carthami, Radix Angelicae Sinensis, Pheretima, Radix Codonopsis, Fructus Forsythiae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Chinese medicine composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Chinese medicine composition of the present invention has effects such as warming YANG to expel cold, a surname promoting blood circulation, QI invigorating and blood regulating, warming the meridian blood stasis dispelling, is used for diseases such as pale, the purplish red and flushing of extremity acra intermittence that raynaud disease causes.

The specific embodiment

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1: Chinese medicinal composition granules of the present invention

(1) to be ground into impalpable powder standby for Radix Salviae Miltiorrhizae 100g;

(2) Flos Lonicerae 300g, Rhizoma Chuanxiong 130g, Radix Paeoniae Rubra 130g, Herba Taraxaci 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Astragali 80g, Fructus Corni 180g, Ramulus Cinnamomi 160g, Cortex Moutan 170g, Fructus Aurantii 160g, Rhizoma Corydalis 250g, Flos Carthami 250g, Radix Angelicae Sinensis 210g, Pheretima 160g, Radix Codonopsis 180g, Fructus Forsythiae 280g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds lactose 400g, dextrin 800g, mixing sieves, with 75% ethanol wet granulation, drying, pack promptly.

Embodiment 2: Chinese medicinal composition capsules agent of the present invention

(1) to be ground into impalpable powder standby for Radix Salviae Miltiorrhizae 100g;

(2) Flos Lonicerae 300g, Rhizoma Chuanxiong 130g, Radix Paeoniae Rubra 130g, Herba Taraxaci 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Astragali 80g, Fructus Corni 180g, Ramulus Cinnamomi 160g, Cortex Moutan 170g, Fructus Aurantii 160g, Rhizoma Corydalis 250g, Flos Carthami 250g, Radix Angelicae Sinensis 210g, Pheretima 160g, Radix Codonopsis 180g, Fructus Forsythiae 280g decoct with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 700g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3: Chinese medicine composition tablet of the present invention

(1) to be ground into impalpable powder standby for Radix Salviae Miltiorrhizae 100g;

(2) Flos Lonicerae 300g, Rhizoma Chuanxiong 130g, Radix Paeoniae Rubra 130g, Herba Taraxaci 210g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Astragali 80g, Fructus Corni 180g, Ramulus Cinnamomi 160g, Cortex Moutan 170g, Fructus Aurantii 160g, Rhizoma Corydalis 250g, Flos Carthami 250g, Radix Angelicae Sinensis 210g, Pheretima 160g, Radix Codonopsis 180g, Fructus Forsythiae 280g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, add starch 300g, microcrystalline Cellulose 200g is with 70% ethanol wet granulation, tabletting, coating are promptly.

Claims (4)

1, a kind of Chinese medicine composition for the treatment of raynaud disease is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according.

Radix Astragali 5-10 part Radix Salviae Miltiorrhizae 5-15 part Fructus Corni 10-25 part

Ramulus Cinnamomi 10-20 part Rhizoma Chuanxiong 10-15 part Cortex Moutan 15-20 part

Radix Paeoniae Rubra 10-15 part Fructus Aurantii 10-20 part Rhizoma Corydalis 20-30 part

Flos Carthami 20-30 part Radix Angelicae Sinensis 15-25 part Pheretima 10-20 part

Radix Codonopsis 10-25 part Herba Taraxaci 15-25 part Fructus Forsythiae 25-30 part

Flos Lonicerae 20-30 part

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according.

18 parts of 10 parts of Fructus Corni of yellow 8 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali

17 parts of 13 parts of Cortex Moutans of 16 parts of Rhizoma Chuanxiongs of Ramulus Cinnamomi

25 parts of 16 parts of Rhizoma Corydalis of 13 parts of Fructus Aurantiis of Radix Paeoniae Rubra

16 parts of 21 parts of Pheretimas of 25 parts of Radix Angelicae Sinensis of Flos Carthami

28 parts of 21 parts of Fructus Forsythiaes of 18 parts of Herba Taraxacis of Radix Codonopsis

26 parts of Flos Loniceraes

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) to be broken into impalpable powder standby for Radix Salviae Miltiorrhizae powder;

(2) Flos Lonicerae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Herba Taraxaci are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Astragali, Fructus Corni, Ramulus Cinnamomi, Cortex Moutan, Fructus Aurantii, Rhizoma Corydalis, Flos Carthami, Radix Angelicae Sinensis, Pheretima, Radix Codonopsis, Fructus Forsythiae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.