KR20200058730A - A composition for preventing hair loss or promoting hair growth - Google Patents

Abstract

The present invention relates to a composition for preventing hair loss or promoting hair growth. More specifically, the present invention relates to a composition for preventing hair loss or promoting hair growth which comprises a compound represented by chemical formula 1; an Eclipta prostrata extract; a Magnolia Kobus bark extract; a Diospyros kaki leave extract; an Angelica gigas root extract; and a Plantago asiatica extract as effective ingredients. The present invention can provide a composition for preventing hair loss or promoting hair growth capable of being easily and simply manufactured, alleviating progress of hair loss, and promoting hair growth. Also, the present invention can provide a composition for preventing hair loss or promoting hair growth capable of minimizing a side effect of sebum generation on the scalp and continuously promoting hair growth.

Description

Composition for preventing hair loss or promoting hair growth {A composition for preventing hair loss or promoting hair growth}

The present invention relates to a composition for preventing hair loss or promoting hair growth, and more specifically, a compound of Formula 1; Hannyeoncho extract; Magnolia bark extract; Persimmon leaf extract; Chamois root extract; And it relates to a composition for preventing hair loss or promoting hair growth comprising the plantain extract as an active ingredient.

Hair loss is known to be due to an unbalanced diet, excessive drinking and smoking, drug use, lack of sleep, stress, childbirth, menopausal disorders, frequent perm and staining, and hormonal imbalance.

Androgen alopecia, which is caused by male hormones and heredity, usually begins in the 40s to 50s, but in severe cases, starts immediately after puberty and lasts for decades. Hair loss begins mainly in the head of the head and gradually progresses to the entire head. In men, the hairline on both sides of the temporal head retreats and hair loss predominates in the head of the head, and in women, the boundary of the facial scalp hair is generally well preserved. , And a complete bald area is rarely formed.

Hair loss, which is caused by these various causes, increases in the number of hair loss as the hair of the parietal and forehead starts to become thinner and loses power. If this phenomenon continues, hair loss becomes severe enough to be observed directly with the naked eye.

In relation to preventing hair loss and promoting hair growth, Korean Patent Publication No. 10-2006-0010035 discloses 10-40% by weight of herbal extracts extracted by heating with herbal medicines of ginseng and gujeolcho in water, 0.1-15% by weight of viscosity modifier, surfactant 30 A hair growth composition using a medicinal herb comprising ∼80% by weight and 0.1 to 15% by weight of oil is disclosed.

In addition, Korean Patent Registration No. 10-1330889 prevents hair loss of a transdermal or topical dosage form containing Valproic acid or a pharmaceutically acceptable salt thereof as an active ingredient in an amount of 0.5 to 30% by weight based on the total weight of the composition, or Disclosed is a composition for promoting hair growth.

On the other hand, Korean Patent Registration No. 10-0846572 discloses a pharmaceutical composition for preventing hair loss and promoting hair growth, which contains an extract of Canavalia gladiata as an active ingredient and contains a pharmaceutically acceptable carrier.

Treatment methods for hair loss include topical application agents, oral medications, dietary supplements, gene transplantation surgery, and hair transplantation surgery. However, these methods have a limited range of use and do not prevent continuous hair loss.

Also, the effect of drug treatment is temporary, and there is a side effect of accelerating the production of scalp or sebum.

In order to solve the above problems, as well as preventing hair loss, new hair is generated, thin hair becomes coarse, and once the hair comes out, it is necessary to develop a product to eat and apply with a normal hair cycle.  

Korean Patent Publication No. 10-2006-0010035 Korean Registered Patent No. 10-1330889 Korean Registered Patent No. 10-0846572

The present invention is to solve the problems of the prior art, it is an object to provide a composition for preventing hair loss or promoting hair growth, which can be easily and simply manufactured and can alleviate the progress of hair loss and promote hair growth.

In addition, the present invention has an object to provide a composition for preventing hair loss or promoting hair growth, which can minimize side effects of accelerated production of scalp or sebum, and promotes continuous hair growth.

In order to achieve the above object, the present invention is a compound of Formula 1; Hannyeoncho extract; Magnolia bark extract; Persimmon leaf extract; Chamois root extract; And it provides a composition for preventing hair loss or promoting hair growth comprising the plantain extract as an active ingredient.

[Formula 1]

In one embodiment of the present invention, the medicinal herb extract, magnolia bark extract, persimmon tree leaf extract, tremella root extract or plantain extract is heat-extracted from a medicinal herb, magnolia bark, persimmon leaf, tremella root or plantain After filtration and concentration under reduced pressure, the concentrate is obtained by freeze-drying.

In one embodiment of the present invention, the heat extraction is 500 to 2,000 parts by weight of solvent with respect to 100 parts by weight of Hannyeoncho, magnolia bark, persimmon leaves, persimmon roots or plantain, and heated at 40 to 95 ° C for 1 to 10 hours. Characterized by extraction.

In addition, the present invention is a compound of Formula 1; Hannyeoncho extract; Magnolia bark extract; Persimmon leaf extract; Chamois root extract; And it provides a food composition for preventing hair loss or promoting hair growth comprising the plantain extract as an active ingredient.

[Formula 1]

In addition, the present invention is a compound of Formula 1; Hannyeoncho extract; Magnolia bark extract; Persimmon leaf extract; Chamois root extract; And it provides a cosmetic composition for preventing hair loss or promoting hair growth comprising the plantain extract as an active ingredient.

[Formula 1]

The present invention can be easily and simply manufactured and can provide a composition for preventing hair loss or promoting hair growth, which can alleviate the progress of hair loss and promote hair growth.

In addition, the present invention can minimize the side effects of accelerated production of scalp or sebum, and can provide a composition for preventing hair loss or promoting hair growth that can promote hair growth continuously.

FIG. 1 shows the hair growth effect after epilation of normal rats and application of the drug to the site for 3 weeks: (a) a drug-untreated control group, (b) minoxidil 5%, (c) When the invention composition is applied
Figure 2 shows the hair growth effect after applying the drug to the hair loss site of the alopecia genetic mouse for 3 weeks: (a) a drug-free control group, (b) when the composition of the present invention is applied
Figure 3 shows the hair growth effect after taking the drug for 3 weeks in alopecia genetic mice.
Figure 4 shows the hair growth effect when the composition of the present invention is treated on the human body.

Hereinafter, the present invention will be described in detail based on examples. The terms, examples, and the like used in the present invention are merely exemplified in order to explain the present invention in more detail and help a person skilled in the art understand, and the scope of the present invention should not be interpreted as being limited thereto.

Technical terms and scientific terms used in the present invention, unless otherwise defined, refer to meanings commonly understood by those skilled in the art to which this invention belongs.

The present invention is a compound of Formula 1; Hannyeoncho extract; Magnolia bark extract; Persimmon leaf extract; Chamois root extract; And it relates to a composition for preventing hair loss or promoting hair growth comprising the plantain extract as an active ingredient.

The composition of the present invention can be used for prevention or treatment purposes for preventing hair loss or promoting hair growth.

The compound of Formula 1 is tripalmitolein, which can be extracted from olive oil.

[Formula 1]

Olive oil is the oil contained in the fruit of the olive tree, and is oiled by compression or extraction. The main component of olive oil is oleic acid, and other saturated or unsaturated fatty acids such as palmitic acid are included.

The olive oil extract is prepared by heating and extracting the olive oil with a solvent, filtration, concentration under reduced pressure, and then freeze-drying the concentrate.

The heat extraction can be extracted by adding 500 to 2,000 parts by weight of solvent with respect to 100 parts by weight of olive oil and heating at 40 to 95 ° C for 1 to 10 hours, and repeatedly extracting with solvent for 1 to 3 hours 1 to 5 times. have.

The solvent may be one or more selected from alcohol, ethanol, methanol, hexane, chloroform, methylene chloride, ethyl acetate and diethylene glycol monoethyl ether.

After heat extraction, the pores are filtered through a filtration membrane having a diameter of 0.2 to 1 µm, the filtered filtrate is concentrated under reduced pressure with a reduced pressure concentrator to remove all of the solvent, then stored in a cryogenic freezer (-70 ° C) and lyophilized to obtain an extract.

The compound of Formula 1 may be separated from the extract by column chromatography.

The isolated compounds were determined by nuclear magnetic resonance analysis (NMR) such as ¹ H NMR and ¹³ C NMR, melting point, and infrared spectroscopy (IR).

In addition, the compound of Formula 1 may be extracted from various oils (seed oil, sunflower oil, grapeseed oil, cottonseed oil, palm oil, rice bran oil, walnut oil, etc.) containing saturated or unsaturated fatty acids in addition to olive oil.

In addition, the present invention may be used by synthesizing the compound of Formula 1, and the origin is not limited.

The extract of Hannyeoncho is prepared by heating extract of Hannyeoncho with a solvent, filtering and then concentrating under reduced pressure, and then freeze-drying the concentrate.

The heat extraction can be extracted by adding 500 to 2,000 parts by weight of solvent with respect to 100 parts by weight of Hannyeoncho and heating at 40 to 95 ° C for 1 to 10 hours, and repeatedly extracting with solvent for 1 to 3 hours 1 to 5 times. .

The solvent may be one or more selected from water, alcohol, ethanol, methanol, hexane, chloroform, methylene chloride, ethyl acetate and diethylene glycol monoethyl ether.

After heat extraction, the pores are filtered through a filtration membrane having a diameter of 0.2 to 1 µm, the filtered filtrate is concentrated under reduced pressure with a reduced pressure concentrator to remove all of the solvent, then stored in a cryogenic freezer (-70 ° C) and lyophilized to obtain an extract.

The magnolia bark extract; Persimmon leaf extract; Chamois root extract; And plantain extract can be prepared in the same way as the method of preparing the extract of Hannyeoncho.

The composition of the present invention is 2 to 15% by weight of the compound of Formula 1; Hannyeoncho extract 0.001 to 0.01 wt%; Magnolia bark extract 0.001 to 0.01 wt%; Persimmon leaf extract 0.001 to 0.01 wt%; Angelica keis root extract 0.001 to 0.01 wt%; Plantain extract 0.001 to 0.01 wt%; And residual amounts of ingredients (tablets, carriers, excipients, diluents, thickeners, emulsifiers, moisturizers, fragrances, etc.).

When the content of the components constituting the composition satisfies the above numerical range, hair loss prevention and hair growth promoting properties may be maximized.

In addition, the composition includes trilinolein, triricinolein, palmitic acid, oleic acid, arachic acid, arachidic acid and arachidonic acid. It may further include.

The composition of the present invention may further include suitable carriers, excipients and diluents commonly used in the manufacture of pharmaceutical compositions.

The carrier, excipients and diluents include lactose, textrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, and crude Vaginal cellulose, polyvinyl phytolidone, water, methylhydroxybenzoate, propyl hydroxybenzoate, talc, magnesium stearate and mineral oil.

The pharmaceutical composition of the present invention can be used by formulating in the form of oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, external preparations, suppositories and sterile injectable solutions.

The pharmaceutical composition of the present invention can be administered to mammals such as humans by various routes, for example, by oral, intravenous, intramuscular or subcutaneous injection.

The pharmaceutical composition of the present invention can be administered or applied topically. Topical administration or topical application means direct application of the composition to the skin or hair.

The topical composition of the present invention can be in the form of a solution, lotion, balm, cream, ointment, liposome, spray, gel, foam, roller stick or any other formulation routinely used in dermatology. .

The pharmaceutical composition of the present invention may be used for the prevention, treatment or improvement of alopecia, wherein the alopecia is alopecia areata, hereditary androgenetic alopecia, telogen effluvium, traumatic alopecia, hair growth wall ( It may be one or more selected from Trichotillomania, Pressure Alopecia, Growth Alopecia, Non-Alopecia Alopecia, Alopecia syphlltiac, Alopecia seborrhecia, Symptomatic Alopecia, Scarring Alopecia, Congenital Alopecia.

In addition, the present invention is a compound of Formula 1; Hannyeoncho extract; Magnolia bark extract; Persimmon leaf extract; Chamois root extract; And it relates to a food composition for preventing hair loss or promoting hair growth comprising the plantain extract as an active ingredient.

Food may be in the form of various foods, candy, beverages, gum, tea, vitamin complexes, health functional foods, and the like, and may be provided in the form of powders, granules, tablets, capsules, beverages, and the like.

In addition, the present invention is a compound of Formula 1; Hannyeoncho extract; Magnolia bark extract; Persimmon leaf extract; Chamois root extract; And it relates to a cosmetic composition for preventing hair loss or promoting hair growth comprising the plantain extract as an active ingredient.

The composition of the present invention is 2 to 15% by weight of the compound of Formula 1; Hannyeoncho extract 0.001 to 0.01 wt%; Magnolia bark extract 0.001 to 0.01 wt%; Persimmon leaf extract 0.001 to 0.01 wt%; Angelica keis root extract 0.001 to 0.01 wt%; Plantain extract 0.001 to 0.01% by weight and the remaining amount of ingredients (tablets, carriers, excipients, diluents, thickeners, emulsifiers, moisturizers, preservatives, fragrances, etc.) may be included.

For example, 2 to 15% by weight of the compound of Formula 1; Hannyeoncho extract 0.001 to 0.01 wt%; Magnolia bark extract 0.001 to 0.01 wt%; Persimmon leaf extract 0.001 to 0.01 wt%; Angelica keis root extract 0.001 to 0.01 wt%; Plantain extract 0.001 to 0.01% by weight and purified water may include 70 to 90% by weight.

In addition, 2 to 15% by weight of the compound of Formula 1; Hannyeoncho extract 0.001 to 0.01 wt%; Magnolia bark extract 0.001 to 0.01 wt%; Persimmon leaf extract 0.001 to 0.01 wt%; Angelica keis root extract 0.001 to 0.01 wt%; Plantain extract 0.001 to 0.01 wt%; Purified water 70-90 wt%; Emulsifier 1-5% by weight; 0.1 to 2% by weight of a thickener; It may contain 1 to 5% by weight of preservatives and 0.1 to 1% by weight of fragrance.

When the content of the components constituting the composition satisfies the above numerical range, hair loss prevention and hair growth promoting properties may be maximized.

The cosmetic composition may be prepared in various forms according to a conventional cosmetic manufacturing method.

For example, the cosmetic composition may be prepared in the form of a cosmetic product, shampoo, hair lotion, hair cream, hair gel, hair tonic, shampoo, conditioner, soap, lotion, essence, mist, etc., which is a conventional cleansing solution, It can be used diluted with astringent and moisturizing solutions.

In addition, the cosmetic composition may include a conventional adjuvant such as stabilizers, solubilizers, vitamins, pigments and fragrances commonly used in the cosmetic composition field, or a carrier acceptable for cosmetics.

Acceptable carriers for cosmetic use include purified water, oil, wax, fatty acids, fatty acid alcohols, fatty acid esters, emulsifiers (xanthan gum, ceteareth-6 oleate, etc.), hygroscopic agents, thickeners (xanthan gum, magnesium aluminum silicate, etc.), viscosity Stabilizers, chelating agents, buffers, preservatives (such as 1,2-hexanediol), moisturizing agents (such as butylene glycol), and lower alcohols can be used without limitation.

Anti-inflammatory agents, anti-bacterial agents, anti-fungal agents, vitamins, sunscreens, antibiotics, perfumes, dyes, etc. may be used as necessary.

The present invention will be described in detail through the following examples. The following examples are only exemplified for the practice of the present invention, and the contents of the present invention are not limited by the following examples.

(Example 1) Preparation of extract

2,500 g of ethanol was mixed with 250 g of olive oil, and then extracted at 50 ° C for 2 hours. After extraction, the filter was filtered through an ADVANTEC NO.2 paper filter, and then concentrated under reduced pressure using a vacuum concentrator to remove all of the solvent.

The concentrate was stored in a cryogenic freezer at -70 ° C and freeze-dried to obtain an extract.

Column chromatography was used to separate the active material from the extract, from which the compound of Formula 1 was separated.

The isolated compounds were determined by nuclear magnetic resonance analysis (NMR) such as ¹ H NMR and ¹³ C NMR, melting point, and infrared spectroscopy (IR).

2,500 g of water was mixed with 250 g of Hannyeoncho and extracted at 50 ° C for 2 hours. After extraction, the filter was filtered through an ADVANTEC NO.2 paper filter, and then concentrated under reduced pressure using a vacuum concentrator to remove all of the solvent.

The concentrated solution was stored in a cryogenic freezer at -70 ° C and freeze-dried to obtain a Hannyeoncho extract.

Magnolia bark extract in the same way as the method for preparing the extract of Hannyeoncho; Persimmon leaf extract; Chamois root extract; And plantain extract.

(Proliferation effect of human dermal papilla cells)

PromoCell Growth Medium was used for cell culture, and cells were cultured at 37 ° C and 5% CO ₂ conditions.

The cultured dermal papilla cells were changed twice a week, and after 6-7 days, the cells were washed with Hepes BSS solution, separated from cells attached with Trypsin / EDTA solution, centrifuged, and then used in an experiment while passage. .

The dermal papilla cells were dispensed in 200 µl increments to 1 × 10 ⁴ cells / well in a 96 well plate, and cultured at 37 ° C. and 5% CO ₂ for 18 hours to allow cells to adhere. After 18 hours, the medium was removed, and 200 µl of the sample was added to the well to which the cells were attached, and cultured for 24 hours.

100 μl of a 3- (4,5-dimethylthiazol) -2,5-diphenyltetrazoliumbromide (MTT) solution was added to the cultured cells, and further cultured for 4 hours under the same culture conditions. At this time, the generated formazan crystals were dissolved in DMSO to measure the absorbance at 570 nm with an ELISA reader, and the measured values within the OD range of 0.00 to 3.50 were used for the experimental results.

(Example 2)

A composition comprising 5% by weight of the compound of Formula 1, 0.002% by weight of the extract of Hannyeoncho, 0.002% by weight of the magnolia bark extract, 0.002% by weight of the persimmon leaf extract, 0.002% by weight of the extract of the root of the perilla root, and 0.002% by weight of the plantain extract.

The composition was used as a sample to measure the proliferation effect of human dermal papilla cells.

Table 1 shows the proliferation effect of human dermal papilla cells when the composition of Example 2 was used as a sample.

It can be seen that the composition of the present invention promotes the growth of the dermal papilla cells, and when the composition of the present invention is used, the growth rate of the papillary cells is improved by 20% or more compared to the control without control of the sample.

Meanwhile, a product (MXD) containing 5% of minoxidil, which is currently commercially available, has a small growth rate of dermal papilla cells (2.9%) compared to the control group.

Growth rate of dermal papilla cells Control 100 MXD 102.9 Example 2 122.6

(Example 3) Hair growth effect when the composition was treated to mice

In the case of treating the composition of Example 2 with mice, the hair growth effect after 3 weeks of hair removal is shown in FIGS. 1 to 3.

1 shows the hair growth effect after epilation of normal mice and application of the drug to the site for 3 weeks.

Compared to the untreated drug control group (1 (a)), when 5% of minoxidil was applied (1 (b)) and when the composition of Example 2 was applied (1 (c)), it showed a high hair growth promoting effect.

Figure 2 shows the hair growth effect after applying the drug to the hair loss site of the hair loss genetic mouse for 3 weeks.

When the composition of Example 2 is applied (2 (b)) compared to the control group (2 (a)) where the drug is not treated, it exhibits a high hair growth promoting effect.

Figure 3 shows the hair growth effect after taking the drug for 3 weeks in alopecia genetic mice.

When the composition of Example 2 was ingested daily for 1 week for 3 weeks compared to the control group not taking the drug, it showed a high hair growth promoting effect.

(Hair growth effect when the composition is treated on the human body)

A hair essence was prepared from the composition of the present invention, and tested for 24 weeks for 44 subjects, and then subjected to hair diameter, subjective evaluation, and the like.

Each subject applied the hair essence to the crown and bangs once daily.

The hair density was calculated as the number of hairs per square centimeter, and the hair diameter was calculated as the average diameter of the 1st to 5th coarse hairs in the measurement area.

In addition, the visual evaluation of the tester and the richness of the subject's hair, the number of hairs that were removed, and the improvement of the bangs were very good (3), better (2), slightly better (1), no change (0), slightly worse (-1), It evaluated by classifying as bad (-2) and very bad (-3).

(Example 4)

5% by weight of compound of formula 1, 0.002% by weight of Hannyeoncho extract, 0.002% by weight of magnolia bark extract, 0.002% by weight of persimmon leaf extract, 0.002% by weight of root sugar extract, 0.002% by weight of plantain extract, 88.24% by weight of purified water, ceteares -6 A composition comprising 3% by weight of oleate, 1% by weight of magnesium aluminum silicate, 2% by weight of 1,2-hexanediol and 0.75% by weight of xanthan gum was prepared, and hair essence was prepared from the composition.

(Comparative Example 1)

0.002% by weight of Hannyeoncho extract, 0.002% by weight of magnolia bark extract, 0.002% by weight of persimmon leaf extract, 0.002% by weight of persimmon root extract, 0.002% by weight of plantain extract, 93.24% by weight of purified water, 3% by weight of ceteareth-6 olebate, A composition comprising 1% by weight of magnesium aluminum silicate, 2% by weight of 1,2-hexanediol and 0.75% by weight of xanthan gum was prepared, and hair essence was prepared from the composition.

(Comparative Example 2)

5% by weight of the compound of Formula 1, 0.002% by weight of magnolia bark extract, 0.002% by weight of persimmon leaf extract, 0.002% by weight of root sugar extract, 0.002% by weight of plantain extract, 88.242% by weight of purified water, 3% by weight of ceteareth-6 %, A composition comprising 1% by weight of magnesium aluminum silicate, 2% by weight of 1,2-hexanediol and 0.75% by weight of xanthan gum, and hair essence was prepared from the composition.

Table 2 shows the hair density and hair diameter when using the hair essences prepared from Examples and Comparative Examples.

Number of hair (pcs / cm ² ) Hair diameter (㎛) Example 4 Before exam 142.91 91.73 8 weeks after the test 141.77 94.95 16 weeks after the test 147.18 96.86 24 weeks after the test 156.05 97.55 Comparative Example 1 Before exam 165.68 96.91 8 weeks after the test 174.00 91.68 16 weeks after the test 157.82 91.82 24 weeks after the test 151.68 90.82 Comparative Example 2 Before exam 156.32 94.51 8 weeks after the test 157.89 93.67 16 weeks after the test 153.28 93.98 24 weeks after the test 155.91 94.73

When the composition of Example 4 was used, it can be seen that the number of hairs and the diameter of the hairs increased.

On the other hand, in Comparative Example 1 without using the compound of Formula 1 and Comparative Example 2 without using the extract of Hannyeoncho, it can be seen that the increase in the number of hairs and the diameter of the hair is insignificant.

Therefore, the composition of the present invention can improve the density and diameter of the hair, thereby alleviating the progress of hair loss and promoting hair growth.

Table 3 shows the visual evaluation, the richness of hair, the number of hairs removed, and the improvement of bangs when using the hair essences prepared from Examples and Comparative Examples.

Visual evaluation Abundance of hair leaving out
Number of hair Improvement of bangs Before exam 0 0 0 0  Example 4 8 weeks after the test 0.05 1.00 0.95 1.05 16 weeks after the test 0.14 1.14 1.05 1.14 24 weeks after the test 0.36 1.45 1.14 1.36 Comparative Example 1 8 weeks after the test 0.00 1.09 1.09 0.86 16 weeks after the test -0.09 1.32 1.09 1.09 24 weeks after the test -0.14 1.23 1.18 1.27 Comparative Example 2 8 weeks after the test 0.01 0.92 1.03 1.04 16 weeks after the test -0.02 0.88 1.01 1.12 24 weeks after the test -0.01 1.01 1.10 1.16

As can be seen from the above table, it can be confirmed that by using the composition of Example 4, there is a considerable improvement in overall appearance and hair growth effect.

Figure 4 shows the hair growth effect after applying the hair essence.

When using the hair essence prepared from the composition of Example 4 shows a high hair growth promoting effect (4 (a)).

On the other hand, when using the hair essence prepared from the composition of Comparative Example 1 (4 (b)) and the composition of Comparative Example 2 (4 (c)), it can be seen that the effect of promoting hair growth is negligible.

Claims (5)

Compound of formula 1;
Hannyeoncho extract;
Magnolia bark extract;
Persimmon leaf extract;
Chamois root extract; And
A composition for preventing hair loss or promoting hair growth, comprising plantain extract as an active ingredient.

[Formula 1]

According to claim 1,
The Hannyeoncho extract, magnolia bark extract, persimmon leaf extract, persimmon ear root extract or plantain extract is extracted by heating and extracting Hannyeoncho, magnolia bark, persimmon leaf, persimmon ear root or plantain with a solvent, concentrated under reduced pressure, and concentrated. A composition for preventing hair loss or promoting hair growth, which is obtained by freeze drying.
According to claim 2,
The heat extraction is characterized by extracting by adding 500-2,000 parts by weight of solvent to 100 parts by weight of Hannyeoncho, magnolia bark, persimmon leaf, persimmon root or plantain and heating at 40-95 ° C for 1-10 hours or Composition for promoting hair growth.
Compound of formula 1;
Hannyeoncho extract;
Magnolia bark extract;
Persimmon leaf extract;
Chamois root extract; And
Food composition for preventing hair loss or promoting hair growth, comprising plantain extract as an active ingredient.

[Formula 1]

Compound of formula 1;
Hannyeoncho extract;
Magnolia bark extract;
Persimmon leaf extract;
Chamois root extract; And
A cosmetic composition for preventing hair loss or promoting hair growth, comprising plantain extract as an active ingredient.

[Formula 1]

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