KR101017709B1 - Cosmetic composition comprising the herbal mixed extract comprising panax ginseng c.a meyer showing hair-growth stimulating activity and preventing activity from hair loss - Google Patents

Abstract

PURPOSE: A composition containing mixture herb extract is provided to prevent dandruff and to promote hair growth without side effect and toxicity to human body. CONSTITUTION: A cosmetic composition which prevents hair loss and dandruff and promotes hair growth contains 0.00001-50 weight%(w/w) of complex herb extract as an active ingredient. The herbs are Panax ginseng C.A Meyer, Thuja occidentalis L., Lycium chinese Miller, Acorus gramineus, Xanthium strumarium L., Glycyrrhiza uralensis and Mentha arvensis var. piperascens. The extract is obtained using water, low alcohol of 1-4 carbon atoms or mixture solvent thereof.

Description

Cosmetic composition having hair loss prevention, dandruff production inhibition and hair growth promoting effect containing complex herbal extracts, such as ginseng Panax ginseng C.A Meyer showing hair-growth stimulating activity and preventing activity from hair loss}

The present invention relates to a cosmetic composition having a hair loss prevention, dandruff production inhibition and hair growth promoting effect containing a combination herbal extract of ginseng, baekbaek leaf, baekbaekpi, gujeolcho, wolfberry, Seokchang, Changja, licorice and mint.

1 Ann Acad Med Singapore 2000 Jan; 29 (1): 42-6, British Herbal Compendium 1992 vol 1. 115-118, Owen R.T. 1981.Drugs of Today, 8: 343-351

Document 2 Taro Nomura et al. Planta Med, 1, 127 (1984)

[Ref. 3] Herbal School Remodeling Conference, Herbal Medicine, Revision 3 (2002)

[Document 4] Yuk Chang-soo, Nam-il Jung, Hyo-jong Lim, Hyundai Pharmaceutical Cooperatives, 381 (1999)

Paus et al., J Invest Dermatol. 113, pp 523-532, 1999

Document 6 Folia Pharmacol. Jpn. (Nippon Yakurigaku Zasshi) 119 (3), 167-174 (2002)

[Document 7] Kang Byung-soo et al., Herbology (2000)

8, Oliver RF, J Embryol Exp Morphol. 15, pp 331-347, 1996; Jahoda et al., Nature. 311, pp 560-562, 1984; Paus et al., J Invest Dermatol. 113, pp 523-532, 1999)

[Document 9] Korean Patent Registration No. 2003-0033225

In recent years, the number of hair loss patients due to various chemicals and stress is rapidly increasing, which has a small impact on health as a medical disease, but causes a great aesthetic and psychological pain for the patient himself. Alopecia manifests in various forms, ranging from mild hair thinning to complete baldness. It appears in various forms due to various causes such as traumatic alopecia, hereditary baldness, and androgenetic alopecia.

The number of hairs on the human body is about 5 million, of which about 100,000 hairs are on the head. The hair is composed of three layers of medulla, cortex, and hair. Hair does not grow for a lifetime, but grows naturally over a period of time. For hair, about 70 to 80 drops per day. The hair growth cycle is usually divided into growth phase, degenerative phase, and resting phase, and the period varies depending on the part of the body. The hair is 85% growing and usually lasts 5-7 years. The degenerative hair is about 2% and begins to fall off after 2-3 weeks of rest (Paus et al., J Invest Dermatol. 113, pp523-532, 1999).

This process begins by hair papilla cells consisting of the dermis stimulate the mosquito matrix cells. Growth of insulin like growth factor (IGF-1), hepatocyte growth factor (HGF), and vascular endotherial growth facter (VEGF) found to be secreted from dermal papilla cells It is thought that the extracellular matrix, which is involved in cell migration and differentiation, promotes hair growth by increasing the amount during the factor and growth phase and decreasing it in the degenerative phase. In alopecia areata, electron microscopic observation of dermal papilla cells shows that the shape and nucleus are deformed and pigment granules or phobias are formed in the cytoplasm. These changes occur before the change of the hair is observed. It can be said that it starts from the change of cells (Folia Pharmacol. Jpn. (Nippon Yakurigaku Zasshi) 119 (3), 167-174 (2002)).

To prevent or alleviate abnormal conditions of capillaries, hair follicles, and epidermis due to such changes in hair, take oral medications such as terbinafine or itraconazole that inhibit fungal infections of the scalp; Shampoos containing selenium sulfide or ketoconazole may also be used. Alopecia areata has corticosteroids, anthralin creams, and minoxidils, but there are various side effects such as irritation and hormonal abnormalities. In addition, there are practically no natural preparations that can strengthen hair roots, promote growth, promote hair growth, and alleviate irritation caused by other chemical additives.

In view of the above, the present invention is a result of searching for a substance effective for the proliferative effect on dermal papilla cells among various natural substances of nature, ginseng, white leaf, baekbaekpi, gujeolcho, wolfberry, Seokchangpo, Changja, licorice, It was found that peppermint extract has this effect, and in order to maximize the efficacy, experiments were conducted in various combinations to find the optimum ratio.

Panax ginseng ginseng CA Meyer ) can be said to be the most healing plant, and the main components are protopanaxadiol and protopanaxatriol (triol) depending on the ratio of aglycone. Contains at least 13 kinds of distilled oils such as ginsenosides (saponins) and panaxynols, organic acids and esters, vitamins such as sterols, nitrogen compounds, folic acid, enzymes, etc. It is known to have various efficacy (Ann Acad Med Singapore 2000 Jan; 29 (1): 42-6, British Herbal Compendium 1992 vol 1. 115-118, Owen RT 1981. Drugs of Today, 8: 343-351) .

Thuja occidentalis L is mainly composed of juniper acid (juniperic acid), dujone (thujone), amiurone (mayurone) and abinic acid (abinic acid), hemolytic bleeding caused by massive hemostasis, various blood fever, It shows efficacy in waste heat seawater dryness, blood fever or post-mortem hair loss, premature ejaculation, and mishap. (Raw Drug Reformed Society, Pharmacognosy, Rev. 3 (2002), Dongmyeongsa)

Morus alba L. ) is a bark of mulberry or other cognate, tubular, semi-glossy or band-shaped bark, 0.1-0.6 cm thick, white-orange yellow on the outside, sometimes white silk-like fibers. Many are exposed. Usually, hypotensive flavonoids are the mainstream, and it is known to have a blood glucose enhancing function (Taro Nomura et al. Planta Med, 1, 127 (1984)).

Licorice ( Glycyrrhiza uralensis is the root and gourd of Glycirrhiza glabra L., G. uralensis Fisher, or the same plant (skin licorice) or peeled (peel). Licorice) will. Extracts include hormonal and anti-inflammatory activity of anti-ulcerative adrenal cortex, anti-inflammatory action, estrogen-hormonal action, detoxification, hyperlipidemia, and interferon organic activity. .

Wolfberry ( Lycium chinese Miller ) is the fruit of the wolfberry tree, using the shade to remove the fruit seeds. The water extract of goji berries shows a marked drop in blood pressure, inhibits the increase of lipids, and anti-interstitial and hepatic function protection. Recently, anti-aging, anti-arteriosclerosis, female hormonal acts, anti-malignant tumors, and hematopoietic function-promoting actions are known, including promoting and regulating immune function. (1999), Culture and Culture History)

Chrysanthemum zawadskii var . latilobum ) is a kind of wild chrysanthemum, and it is known to be effective in gynecological disease and warmth. In addition, gujeolcho is effective in preventing headache and hair loss, and prevents whitening of hair, and is known to be effective in healthy stomach, bowel, tonic, blood donation, appetite promotion, stroke and neuralgia. Furthermore, choline, known to be contained in gujeolcho, is an important basic structural unit of acetylcholine, a chemical that is involved in memory formation in the brain, and is known to play an important role in forming cell membranes in each tissue of the body. (Yook Chang-su, Nam-il Jung, Hyo-jong Lim, Hyundai Pharmaceutical Cooperatives, 381 (1999), Culture and Culture History)

Seokchangpo ( Acorus gramineus ) is called Swordweed, Seokchocho, etc., because it grows before other grasses, it is called iris that means that it is full of yang because it started to plow the field. It warmed up and lived long. Essential oils have a calming effect, so it is better to use for people with anxiety. When itching with eczema or skin disease, it is said to be improved by washing the sore spots with decoction of Seokchangpo. The root of Seokchangpo is known to improve complexion and blacken gray hair. (Kang Byung-soo et al., Herbology (2000))

Chang'anza ( Xanthium strumarium L. ) is a fruit of asteraceae or large-tailed Asteraceae, which is an annual herb that grows widely in the fields of our country. The components of the outpost are lactones such as xanthinine, carotenoids, alkaloids and saponins, and the fruit changja contains xanthostrumarin (yellow glycosides), resins, and iodine salts, and seeds contain resins, linoleic acid, oleic acid, saturated fatty acids, etc. Contains oil. Also, Docomari is one of the plants with high iodine content (National Herbal Medicine Remodeling Society, Herbal Medicine, Rev. 3 (2002), Dongmyeongsa)

Peppermint ( Mentha arvensis var . piperascens ) is a stem and leaf of a perennial herb of Lamiaceae, which contains volatile essential oils, contains 77% of menthol, the main ingredient, and has a strong divergence, which causes fever, headache and sweating. It is used for treating symptoms, eliminating headaches and redness of the eyes, and for itching of the skin. It is used in combination with abdominal pain, diarrhea and vomiting caused by moisture and pathogen invasion in summer, and it is used for capillary dilation. , Pharmacology, Revision 3 (2002)

Accordingly, the present inventors continue to search for raw materials having excellent stability and hair growth improvement among herbal extracts used as herbal medicines, and selected from the group consisting of ginseng, baekyeop, baekbaekpi, gujeolcho, wolfberry, Seokchangpo, Changja, licorice and mint. The present invention was completed by confirming that one or more complex herbal extracts have an effect of preventing hair loss, inhibiting dandruff production, and improving hair growth.

In order to carry out the above object, the present invention is a cosmetic having a hair loss prevention, dandruff production inhibition and hair growth promoting effect containing a complex herbal extract of ginseng, baekyeop, baekbaekpi, gujeolcho, gojija, Seokchangpo, Changja, licorice, mint as an active ingredient To provide a composition.

The extract as defined herein includes water, including purified water, lower alcohols having 1 to 4 carbon atoms or mixed solvents thereof, preferably extracts soluble in water.

Complex herbal extract of the present invention ginseng, baekbaek leaf, baekbaekpi, gujeolcho, wolfberry, Seokchangpo, Changja, licorice, peppermint weight ratio of 1 ~ 10: 1 ~ 10: 1 ~ 10: 1 ~ 10: 1 ~ 10: 1 ~ 10: 1 ~ 15: 1 ~ 10: 1 ~ 15 weight ratio (w / w), preferably ginseng, baekbaek leaf, baekbaekpi, gujeolcho, wolfberry, Seokchangpo, Changja, licorice, peppermint weight ratio of 1 ~ 9: 1 9: 1-9: 1-9: 1-9: 1-9: 1-12: 1-9: 1-12: weight ratio (w / w) of 1-12, more preferably ginseng, white leaf, baekbaekpi, gujeolcho, Weight ratio of wolfberry, Seokchang, Changja, licorice and mint is 1-3: 1-3: 1-3, 1-3: 1-3, 1-3: 1-4: 1-3, 1-4: It characterized in that (w / w).

The cosmetic composition is a hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair moisturizing cream, hair massage cream, hair wax, hair aerosol , Hair pack, nourishment pack, hair soap, hair cleansing foam, hair oil, hair drier, hair preservative, hair dye, hair wave, hair bleach, hair gel, hair glaze, hair dresser, hair lacquer, hair moisturizer, Formulations of hair mousse or hairspray.

Hereinafter, a method of obtaining the complex herbal extract of the present invention will be described in detail.

Complex herbal extract of the present invention is washed, dried and shredded ginseng, baekbaek leaf, baekbaekpi, gujeolcho, wolfberry, Sukchangpo, Changja, licorice and mint, respectively, ginseng, baekyeop, baekbaekpi, gujeolcho, wolfberry, Sukchangpo, Changja, licorice, mint The weight ratio of 1 to 10: 1 to 10: 1 to 10: 1 to 10: 1 to 10: 1 to 10: 1 to 15: 1 to 10: 1 to 15 of weight ratio (w / w), preferably Ginseng, white leaf, baekbaekpi, gujeolcho, wolfberry, Seokchangpo, Changja, licorice, peppermint weight ratio of 1 ~ 9: 1 ~ 9: 1 ~ 9: 1 ~ 9: 1 ~ 9: 1 ~ 9: 1 ~ 12: 1 ˜9: 1 to 12 weight ratio (w / w), more preferably ginseng, cedar leaf, baekbaekpi, gujeolcho, wolfberry, Seokchangpo, changja, licorice, peppermint weight ratio of 1 to 3: 1 to 3: 1 to 3 1: 1: 1: 1: 1: 3: 1: 3: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1; Water containing about 1 to 200 times (w / w), preferably 10 to 100 times (w / w) purified water, lower alcohols having 1 to 4 carbon atoms or mixed solvents thereof, preferably The water is added for 1 hour to 10 hours, preferably 2 hours to 6 hours at 100 ℃ extraction method such as cold extraction, hot water extraction, ultrasonic extraction, reflux cooling extraction, preferably, by performing a hot water extraction method Obtaining a second step; The crude herbal extract of the present invention may be obtained through the third step of preparing the filtrate by filtering the extract obtained above with a filter cloth and filtering the filtrate.

The present invention provides a cosmetic composition having a hair loss prevention, dandruff production suppression and hair growth promoting effect containing the complex herbal extract obtained by the above production method as an active ingredient.

The complex herbal extract obtained by the extraction method was confirmed that the liver growth effect using the human body showed a hair growth effect.

The composition having the hair loss prevention, dandruff production inhibition and hair growth promoting effect of the present invention, 0.00001 to 50% by weight (w / w), preferably 0.0001 to 20% by weight of the composite herbal extract based on the total weight of the composition (w / w), more preferably 0.1 to 10% by weight (w / w).

However, the composition as described above is not necessarily limited thereto, and may vary according to the condition and the degree of progression of the patient.

The composition of the present invention can be used in a variety of hair cosmetics having hair loss prevention, dandruff production inhibition and hair growth promoting effect. Examples of products to which the composition can be added include, for example, hair tonics, hair conditioners, hair essences, hair lotions, hair nutrition lotions, hair shampoos, hair rinses, hair treatments, hair creams, hair nutrition creams, hair moisturizers. Cream, hair massage cream, hair wax, hair aerosol, hair pack, hair nutrition pack, hair soap, hair cleansing foam, hair oil, hair dryer, hair preservative, hair colorant, hair wave agent, hair bleach, hair gel, hair glaze, Cosmetics such as hair dressers, hair lacquers, hair moisturizers, hair mousses or hair sprays and the like.

Cosmetics of the present invention comprises a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids and seaweed extract.

The water-soluble vitamins may be any compound that can be incorporated into cosmetics, but preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H, and the like. Their salts (thiamine hydrochloride, sodium ascorbate salt, etc.) and derivatives (ascorbic acid-2-sodium phosphate salt, ascorbic acid-2-magnesium phosphate salt, etc.) may also be used in the water-soluble vitamins that can be used in the present invention. Included. The water-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification from microorganism culture, enzyme or chemical synthesis.

The oil-soluble vitamin may be any compound that can be formulated into cosmetics, but preferably vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol), and the like. And derivatives thereof (ascorbic palmitate, ascorbic stearate, ascorbic acid dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherolvitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, pantotenylethyl Ethers, etc.) are also included in the oil-soluble vitamins used in the present invention. Oil-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification of microorganism culture, enzyme or chemical synthesis.

The polymeric peptide may be any compound as long as it can be compounded in cosmetics, and examples thereof include collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, and keratin. Polymeric peptides can be purified and obtained by conventional methods such as purification from microbial cultures, enzymatic methods or chemical synthesis methods, or can be purified and used from natural products such as dermis and pig silk such as pigs and cattle.

The polymer polysaccharide may be any compound as long as it can be incorporated into cosmetics. Preferably, hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or a salt thereof (sodium salt, etc.) may be mentioned. For example, chondroitin sulfate or its salt, etc. can be normally purified from a mammal or fish.

The sphingolipid may be any compound as long as it can be blended into cosmetics. Preferably, ceramide, phytosphingosine, sphingosaccharide lipid, etc. may be mentioned. Sphingo lipids can usually be purified from mammals, fish, shellfish, yeasts or plants by conventional methods or obtained by chemical synthesis.

The seaweed extract may be any compound as long as it can be blended into cosmetics. Preferably, the seaweed extract may include brown algae extract, red algae extract, green algae extract, and the like. Also, calginine, arginic acid, sodium arginate, Potassium arginate and the like are also included in the seaweed extract used in the present invention. Seaweed extract can be obtained by purification from seaweed by conventional methods.

In addition to the said essential component, you may mix | blend the cosmetics of this invention with the other components normally mix | blended with cosmetics as needed.

Other components that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, flavorings, Blood circulation accelerators, cooling agents, restriction agents, purified water and the like.

Examples of the fat or oil component include ester fats, hydrocarbon fats, silicone fats, fluorine fats, animal fats, and vegetable fats and oils.

As ester fats and oils, glyceryl tri2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl mystinate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, and stearic acid Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl acid isocetyl, isostyl acid isostearyl, isostaryl palmitate, octylate acid octyldodecyl, isostearic acid isetyl, diethyl sebacate, adipine Acid isopropyl, isoalkyl neopentane, tri (capryl, capric acid) glyceryl, trimethyl ethyl trimethylol propane, triisostearic acid trimethylol propane, tetra 2-ethylhexanoic penta erythritol Cetyl caprylate, lauric acid decyl, hexyl laurate, decyl myristin, myristin acid myristyl, myritic acid cetyl, stearyl stearate, decyl oleate, rininooleic acid , Isostearyl laurate, isotridecyl myristin, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecate oleate, octylate decyl oleate, octyl dodecyl linoleate, isopropyl isopropyl acid, 2 -Cetostearyl ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicapric acid, propylene glycol dicacapate, capric acid Propylene glycol, dicapric acid neopentyl glycol, dioctanoate neopentyl glycol, tricaprylic acid glyceryl, triundecyl glyceryl, triisopalmitinate glyceryl, triisostearate glyceryl, neopentane dodecyl Isostearyl octanoate, octyl isononate, hexyl decyl neodecanoate, octyl dodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, Sothete octylate, polyglycerol oleate, polyglycerine isostearate, triisocetyl citrate, triisoalkyl citrate, triisooctyl citrate, lauryl lactate, myritic lactate, octyl lactate, octyl lactate Ethyl, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, diisostearyl malic acid, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipicate, diisopropyl sebacinate, Dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, physteryl isostearate, phytic oleate, 12-Steloylhydroxystearate isocetyl, 12-Steloylhydroxystearate stearyl, 12-stealo Esters such as monohydroxystearic acid isostearyl; and the like.

Hydrocarbon-based fats and oils, such as squalene, a liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, a liquid isoparaffin, polybutene, microcrystal wax, and a vaseline, etc. are mentioned as a hydrocarbon-type fats and oils.

Examples of the silicone-based oils and fats include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane, methylcetyloxysiloxane copolymer, dimethylsiloxane and methylsteoxysiloxane copolymer, and alkyl. Modified silicone oil, amino modified silicone oil and the like.

Examples of the fluorine-based oil include perfluoropolyether and the like.

Animal or vegetable oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, soybean oil, soybean oil, corn oil, rapeseed oil, almond oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil. , Cottonseed oil, Palm oil, Cucumber nut oil, Wheat germ oil, Rice germ oil, Shea butter, Walnut colostrum oil, Marker demia nut oil, Meadow home oil, Egg yolk oil, Uji, Horse oil, Mink oil, Orange rape oil, Jojoba oil And animal or plant fats and oils such as candeler wax, carnava wax, liquid lanolin and hardened castor oil.

Examples of the moisturizing agent include a water-soluble low molecular moisturizer, a fat-soluble molecular moisturizer, a water-soluble polymer, and a fat-soluble polymer.

Water-soluble low molecular humectants include serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene Glycol (polymerization degree n = 2 or more), polyglycerol B (polymerization degree n = 2 or more), lactic acid, lactic acid salt, etc. are mentioned.

Examples of the fat-soluble low molecular humectants include cholesterol and cholesterol esters.

Examples of the water-soluble polymer include carboxyvinyl polymer, polyasparaginate, tragacanth, xanthan gum, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water soluble chitin, chitosan, and dextrin. Can be.

Examples of the fat-soluble polymers include polyvinylpyrrolidone-eicosene copolymers, polyvinylpyrrolidone-hexadecene copolymers, nitrocellulose, dextrin fatty acid esters, polymer silicones, and the like.

Examples of the emollient include long-chain acyl glutamic acid cholesteryl esters, hydroxy stearic acid cholesterol, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl esters, and the like.

As surfactant, nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant, etc. are mentioned.

As nonionic surfactant, self-emulsifying glycerin monostearate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerol fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE Glycerin Fatty Acid Ester, POE Alkyl Ether, POE Fatty Acid Ester, POE Cured Castor Oil, POE Castor Oil, POE / POP (Polyoxyethylene / Polyoxypropylene) Copolymer, POE / POP Alkyl Ether, Polyether Modified Silicone, Laurin Acid Alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, etc. are mentioned.

Anionic surfactants include fatty acid soaps, alpha-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates, alkylamide sulfates, alkyl phosphates, POE alkylphosphates, and alkylamides. Phosphates, alkyloylalkyltaurine salts, N-acylamino acid salts, POE alkyl ether carboxylate salts, alkyl sulfosuccinate salts, sodium alkyl sulfo acetates, acylated hydrolyzed collagen peptide salts, perfluoroalkyl phosphate esters, and the like. have.

As cationic surfactant, alkyl trimethylammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, cetostearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl benzyl ammonium bromide, behenyl trimethyl ammonium chloride, chloride Benzalkonium, diethylaminoethyl stearate, dimethylaminopropyl stearate, lanolin derivatives, quaternary ammonium salts, and the like.

Examples of amphoteric surfactants include the carboxybetaine type, the amide betain type, the sulfobetain type, the hydroxysulfobetain type, the amide sulfobetain type, the phosphobetaine type, the aminocarboxylate type, the imidazoline derivative type, and the amideamine type. An amphoteric surfactant etc. are mentioned.

Examples of the organic and inorganic pigments include inorganic pigments such as silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, Bengala, clay, bentonite, titanium mica, titanium oxide, bismuth chloride, zirconium oxide, magnesium oxide, Inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, chromium oxide, chromium oxide, chromium hydroxide, Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene, styrene copolymer, Organic pigments such as silk powder, cellulose, CI pigment yellow, CI pigment orange, and composite pigments of these inorganic pigments and organic pigments;

As organic powder, Metal soaps, such as a calcium stearate; Alkyl phosphate metal salts such as sodium cetylinate, zinc lauryl acid and calcium laurate; Acylamino acid polyvalent metal salts such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroylglycine calcium; Amide sulfonic acid polyvalent metal salts, such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N-epsilon-lauroyl-L-lysine, N-epsilon-palmitolyzine, N-alpha-paratoylol nitin, N-alpha-lauroyl arginine, N-alpha-cured fatty acid acyl arginine -Acyl basic amino acid; N-acyl polypeptides, such as N-lauroyl glycyl glycine; Alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; Polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene-styrene copolymer, ethylene tetrafluoride and the like.

Examples of the ultraviolet absorber include paraaminobenzoic acid, ethyl paraaminobenzoate, amyl paraaminobenzoic acid, octyl paraaminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomentyl salicylic acid and benzyl cinnamic acid. , Paramethoxy cinnamic acid-2-ethoxyethyl, paramethoxy cinnamic acid octyl, diparamethoxy cinnamic acid mono-2-ethylhexaneglyceryl, paramethoxy cinnamic acid isopropyl, diisopropyl diisopropyl cinnamic acid ester mixture, wuro Canonic acid, ethyl urokanoate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and salts thereof, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium sulfonate, dihydroxybenzophenone , Tetrahydroxybenzophenone, 4- tert -butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino- p- (carbo-2'-ethylhexyl-1'-oxy) -1 , 3,5-triazine, 2- (2-hi And the like can be mentioned hydroxy-5-methylphenyl) benzotriazole.

As fungicides, hinokithiol, trichloric acid, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, ginxitlionone, benzalkonium chloride, photosensitive Sodium No. 301, sodium mononitrohydrol, undecylenic acid, and the like.

Examples of the antioxidant include butylhydroxyanisole, propyl gallic acid, and erythorbic acid.

Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fmaric acid, sodium pmarate, succinic acid, sodium succinate, sodium hydroxide, sodium dihydrogen phosphate, and the like.

Examples of the alcohol include higher alcohols such as cetyl alcohol.

In addition, the compounding component which may be added other than this is not limited to this, Although any said component can be mix | blended within the range which does not impair the objective and effect of this invention, Preferably it is 0.01 to 5% weight percentage with respect to a total weight, More Preferably 0.01 to 3% by weight.

The cosmetic of the present invention may take the form of a solution, an emulsion, a viscous mixture, or the like.

Components included in the cosmetic composition of the present invention may include components commonly used in cosmetic compositions in addition to the complex herbal extract as an active ingredient, for example, such as stabilizers, solubilizers, vitamins, pigments and flavorings Phosphorus aids and carriers.

The cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, and includes, for example, milky lotion, cream, lotion, pack, foundation, lotion, essence, hair cosmetic, and the like.

When the formulation of the present invention is a paste, cream or gel, animal carriers, vegetable fibers, waxes, paraffins, starches, tracantes, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide, etc. may be used as carrier components. Can be.

In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solvating or emulsifying agent is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the dosage form of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The composition for preventing hair loss and promoting hair growth containing the complex herbal extracts of ginseng, egret, cilantro, gujeolcho, goji berry, changchang, changja, licorice and peppermint of the present invention has no side effects or toxicity to the human body, and hair loss through a simple clinical trial. Since it shows the prevention and hair growth promoting effect, it can be usefully used as a cosmetic composition showing the hair loss prevention, dandruff suppression production, and hair growth promoting effect.

Hereinafter, the present invention will be described in detail with reference to the following examples and experimental examples.

However, the following Examples and Experimental Examples are merely illustrative of the present invention, and the content of the present invention is not limited by the following Examples and Experimental Examples.

Reference Example  1. Preparation of Sample

Ginseng, baekbaekpi, changja, baekbaekye, gojija, Seokchangpo, licorice, gujeolcho and mint used in the present invention were purchased from Kyungdong Pharmaceutical Market.

Reference Example  2. Extraction of Sample

Weight mix ratio of ginseng, baekbaekpi, changja, baekbaek leaf, gojija, Seokchangpo, licorice, gujeolcho and mint purchased from Kyungdong Pharmaceutical Market 0 ~ 1: 0 ~ 1: 0 ~ 1: 0 ~ 1: 0 ~ 1: 0 ~ 1 : 0 ~ 1: 0 ~ 1: 0 ~ 1 The weight ratio (w / w) was added to 10 times the amount of raw material and extracted for 3 hours at a temperature of 100 ℃, 250 mesh filter cloth (NBC inc. 38T05221-06 ) Was filtered through a 0.5um filter (MILLIPORE HVLP04700) and concentrated in a vacuum condenser (BUCHI Rotavapor R-210) with a cooler. The results are shown in Table 1 below.

Raw material (× 10 ² g) use
Solvent Amount (kg) Yield
(g) Ginseng White skin Changza Temporal lobe Wolfberry Seokchangpo licorice Gujeolcho mint One One 0 0 0 0 0 0 0 0 One 8.9 2 0 One 0 0 0 0 0 0 0 One 12.3 3 0 0 One 0 0 0 0 0 0 One 5.4 4 0 0 0 One 0 0 0 0 0 One 2.2 5 0 0 0 0 One 0 0 0 0 One 10.3 6 0 0 0 0 0 One 0 0 0 One 14.5 7 0 0 0 0 0 0 One 0 0 One 11.3 8 0 0 0 0 0 0 0 One 0 One 12.3 9 0 0 0 0 0 0 0 0 One One 7.4

Example  1. Preparation of complex herbal extracts such as ginseng

Weight mix ratios of ginseng, baekbaekpi, changja, baekbaekye, gojija, Seokchangpo, licorice, gujeolcho and mint purchased from Kyungdong Pharmaceutical Market 1-3 ~ 1: 1 ~ 3: 1 ~ 3: 1 ~ 3: 1 ~ 3 : 1 to 4: 1 to 3: 1 to 4 by weight ratio (w / w) of purified water extracted 10 times the amount of raw material for 3 hours at a temperature of 100 ℃, 250 mesh filter cloth (NBC inc. 38T05221-06) Filtered with a 0.5um filter (MILLIPORE HVLP04700) and concentrated in a vacuum condenser (BUCHI Rotavapor R-210) equipped with a cooler to extract 110 g (12.22%) of crude herbal extract-1 (hereinafter referred to as “BH-1”). ), 132g (12.00% yield) of herbal extract-2 (hereinafter referred to as "BH-2"), 104g (yield 9.45%) of complex herbal extract-3 (hereinafter referred to as "BH-3" ), 120 g (10.91% yield) of herbal extract-4 (hereinafter referred to as "BH-4"), 98 g (yield 8.91%) of complex herbal extract-5 (hereinafter referred to as "BH-5" ), 104 g (yield 9.45%) of complex herbal extract-6 (hereinafter, “ BH-6 ”), 148g (13.45% yield) of complex herbal extract-7 (hereinafter referred to as“ BH-7 ”), 99.0g (yield 9.00%) of complex herbal extract-8 (hereinafter, “BH-8”), 135 g (12.27% yield) of complex herbal extract-9 (hereinafter referred to as “BH-9”), 115 g (10.45% yield) of complex herbal extract-10 (hereafter, “BH-10”), 168g (11.20% yield) of complex herbal extract-11 (hereinafter referred to as “BH-11”), 175g (yield 11.67%), complex herbal extract-12 (hereinafter, “BH-12”), 115g (7.7% yield) of herbal extract-13 (hereinafter referred to as “BH-13”), 190g (12.67% yield) of complex herbal extract-14 (hereafter, "BH-14"), 141g (10.07% yield) of the herbal extract extract-15 (hereinafter referred to as "BH-15"), 179g (yield 11.93%) of the complex herbal extract-16 (hereafter, “BH-16”), 156 g (9.18% yield) of herbal extract-17 (hereinafter referred to as “BH-17”), 19 3 g (12.06% yield) of complex herbal extract-18 (hereinafter referred to as “BH-18”) and 191 g (yield 11.24%) of complex herbal extract-19 (hereinafter referred to as “BH-19”) Obtained (see Table 2).

Raw material (× 10 ² g) use
Solvent Amount (kg) Yield
(g) Ginseng White skin Changza Temporal lobe Wolfberry Seokchangpo licorice Gujeolcho mint BH-1 One One One One One One One One One 9 110 BH-2 3 One One One One One One One One 11 132 BH-3 One 3 One One One One One One One 11 104 BH-4 One One 3 One One One One One One 11 120 BH-5 One One One 3 One One One One One 11 98 BH-6 One One One One 3 One One One One 11 104 BH-7 One One One One One 3 One One One 11 148 BH-8 One One One One One One 3 One One 11 99.0 BH-9 One One One One One One One 3 One 11 135 BH-10 One One One One One One One One 3 11 115 BH-11 One One One 3 2 2 2 One 2 15 168 BH-12 One One One 2 3 2 2 One 2 15 175 BH-13 One One One 2 2 3 2 One 2 15 115 BH-14 One One One 2 2 2 3 One 2 15 190 BH-15 One One One 2 2 2 2 One 2 14 141 BH-16 One One One 2 2 2 2 One 3 15 179 BH-17 One One One 2 2 2 4 One 3 17 156 BH-18 One One One 2 2 2 3 One 3 16 193 BH-19 One One One 2 2 2 3 One 4 17 191

Example  2. Preparation of complex herbal extracts such as ginseng

Ginseng 10g, Sangbaekpi 10g, Changjaja 10g, Siegyebap 20g, Gugija 20g, Seokchangpo 20g, Licorice 30g, Gujeolcho 10g, Mint 30g in Kyungdong Pharmaceutical Market, extracted at room temperature for 7 days, 250 Filter with a mesh filter cloth (NBC inc. 38T05221-06) and filter with a 0.5um filter (MILLIPORE HVLP04700) to give 14.3 kg (95.33% yield) of the composite herbal extract-20 (hereinafter referred to as “BH-PG”). Obtained.

Example  3. Preparation of complex herbal extracts such as ginseng

Ginseng 10g, Sangbaekpi 10g, Changjaja 10g, Siegyebap 20g, Gugija 20g, Seokchangpo 20g, Licorice 30g, Gujeolcho 10g, Mint 30g in Gyeonggi Pharmaceutical Market, extracted at room temperature for 15 days, 250 mesh, 250 mesh Filter with filter cloth (NBC inc. 38T05221-06) and filter with 0.5um filter (MILLIPORE HVLP04700) to obtain 13.7kg (yield 91.33%) of composite herbal extract-21 (hereinafter referred to as "BH-EtOH"). It was.

Example  4. Preparation of complex herbal extracts such as ginseng

Ginseng 10g, Sangbaekpi 10g, Changjaja 10g, Siegyeob 20g, Gugija 20g, Seokchangpo 20g, Licorice 30g, Gujeolcho 10g, Mint 30g in Kyungdong Pharmaceutical Market, extracted at room temperature for 7 days, and extracted for 7 days at room temperature, Filtered with 250 mesh filter cloth (NBC inc. 38T05221-06) and filtered with 0.5 um filter (MILLIPORE HVLP04700) to 13.7 kg (91.33% yield) of composite herbal extract-22 (hereinafter referred to as “BH-BG”) Obtained.

Experimental Example 1 . In dermal papilla cells  Proliferation effect

In order to confirm the proliferative effect on dermal papilla cells of the samples obtained in Examples 1 to 4, the experiment was conducted by applying the method disclosed in the literature as follows. (Oliver RF., J Embryol Exp Morphol. 15, pp331 -347, 1996; Jahoda et al., Nature. 311, pp560-562, 1984; Paus et al., J Invest Dermatol. 113, pp523-532, 1999).

Rat Vibrissa immortalized dermal papilla cells of 6-week-old females at 100-week-old females were given 100 units / ml, penicillin-100 μg / ml streptomycin (Gibco Inc, NY, USA). ) And DMEM (Hyclone Inc, USA) medium containing 10% heat-inactivated fetal bovin serum (FBS; Gibco Inc, NY, USA) using a 5% CO₂ thermostat (REVCO ELITE II, RC03000T) at 37 ° C. -5-VBC) and passaged once every 3 days. The proliferation of rat vibrissa immortalized dermal papilla cells was measured by MTT assay. Dermal papilla cells (1.0 × 10 ⁴ cells / ml) were put into 96 well plates and incubated for 24 hours, exchanged with serum-free DMEM medium, and incubated for another 24 hours, and then obtained in Examples 1 to 4, respectively. The extract was treated to 1 ~ 5ug / ml. A positive control, minoxidil sulfate (Sigma, USA) was treated at a concentration of 1 μM. After incubation for 4 days, 50 μl of MTT (Sigma, MO, USA) was added and reacted for 4 hours. The supernatant was removed, 200 μl of DMSO was added to dissolve the precipitate, and the absorbance was measured at 540 nm using a microplate reader (Amersham Pharmacia Biotech, NY, USA). Average absorbance values for each sample group were obtained, and the results for the degree of proliferation were compared with those of the control group.

Experimental substance Cell proliferation effect (%) 1ug / ml 5ug / ml BH-1 105 119 BH-2 109 127 BH-3 110 123 BH-4 101 126 BH-5 108 133 BH-6 103 140 BH-7 108 147 BH-8 108 146 BH-9 110 131 BH-10 113 148 BH-11 119 140 BH-12 112 155 BH-13 110 152 BH-14 121 169 BH-15 116 167 BH-16 115 167 BH-17 125 174 BH-18 139 192 BH-19 121 172 BH-PG 134 189 BH-EtOH 128 191 BH-BG 134 179 Minoxidil (positive control) 107 143

Experimental Example  2. hair tonic  And hair  Conditioner Prevents Hair Loss and Dandruff

In order to confirm the proliferative effect on dermal papilla cells of the samples obtained in the above example, the experiment was performed by applying the method disclosed in the literature as described below.

Twenty hair loss and hair loss of 23 to 45 years old were selected, and 10 to about hair tonic and hair conditioner formulated as shown in Table 4 (Prescription Example of Hair Tonic) and Table 5 (Prescription Example of Hair Conditioner) 1 was used and 10 patients were tested for 1 month using Comparative Example 1. At least one day, the product was applied directly to the scalp with reduced hair, and then rubbed gently until it soaked.

At this time, the evaluation of the survey was very excellent (5 points), excellent (4 points), moderate (3 points), no effect (2 points), very ineffective (1 point) and the results are shown in Table 6 below. Shown in

Formulation Example 1 Comparative Formulation Example 1 Very good (five points) 7 0 Excellent (4 points) 3 One Normal (three points) 0 4 No effect (two points) 0 5 Very ineffective (one point) 0 0 evaluation (5 × 7 + 4 × 3 + 3 × 0 + 2 × 0 + 1 × 0) / 10
= 4.7 (5 × 0 + 4 × 1 + 3 × 4 + 2 × 5 + 1 × 0) / 10
= 2.6

Hereinafter, the preparation examples of the composition including the extract of the present invention, but the present invention is not intended to limit it, but is intended to explain in detail only.

Formulation example  1. Preparation of Hair Tonic

Resorcinol 0.1%

Menthol 0.05%

Panthenol 0.2%

Salicylic Acid 0.1%

Tocopheryl Acetate 0.1%

Pyridoxine hydrochloride 0.1%

Castor Oil 5.0%

BH-18 10.0%

Pigment amount

Spices

Ethanol

Purified water level

Total 100.0%

Formulation example  2. Of hair conditioner  Produce

Cetanol 3.5%

Self-emulsifying glycerin monostearate 1.5%

Propylene Glycol 2.5%

Stearylmethylbenzyl Ammonium Chloride (25%) 7.0%

0.3% methyl paraoxybenzoate

BH-15 2.5%

Pigment amount

Spices

Purified water level

Total 100.0%

Formulation example  3. Hair lotion  Produce

Resorcinol 2.0%

Menthol 2.0%

Panthenol 0.5%

Pyroctonolamine 0.1%

BH-8 5.0%

Fragrance, pigment 0.5%

Purified water level

Total 100.0%

Formulation example  4. Hair soap  Produce

BH-PG 0.1%

Titanium dioxide 0.2%

Polyethylene Glycol 0.8%

Glycerin 0.5%

Ethylenediaminetetraacetic Acid 0.05%

Sodium 1.0%

Pigment amount

Soap flavor

Cosmetic soap base (13% moisture, parts by weight)

Total 100.0%

Claims (6)

Panax ginseng CA Meyer, Thuja occidentalis L, Morus alba L., Chrysanthemum zawadskii var.latilobum, Lycium chinese Miller, Acorus gramineus, Xanthium strumarium L .), A cosmetic composition having the effect of preventing hair loss, inhibiting dandruff production, and promoting hair growth, comprising a complex herbal extract of Glycyrrhiza uralensis and mint (Mentha arvensis var. Piperascens) as an active ingredient. The method of claim 1, wherein the complex herbal extract is Panax ginseng CA Meyer, Thuja occidentalis L, Morus alba L. Chrysanthemum zawadskii var. Latilobum, Lycium chinese Miller, Weight mix ratio of Acorus gramineus, Changza (Xanthium strumarium L.), licorice (Glycyrrhiza uralensis) and peppermint (Mentha arvensis var. 10: 1 to 10: 1 to 15: 1 to 10: the cosmetic composition characterized in that the weight ratio (w / w) of 1 to 15. The method of claim 1,
The extract is a cosmetic composition which is an extract available in water, including purified water, lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof. The method of claim 1,
The cosmetic composition is a hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair moisturizing cream, hair massage cream, hair wax, hair aerosol , Hair pack, hair nutrition pack, hair soap, hair cleansing foam, hair oil, hair dryer, hair preservative, hair dye, hair wave, hair bleach, hair gel, hair glaze, hair dresser, hair lacquer, hair moisturizer, Cosmetic composition which is a formulation of hair mousse or hairspray. The cosmetic composition of claim 1 comprising 0.00001 to 50% by weight (w / w) of the complex herbal extract based on the total weight of the composition. delete