KR20130033623A - Topical composition comprising the herbal mixed extract including persimmon leaf showing hair-growth stimulating activity and preventing effect on hair loss - Google Patents

Abstract

PURPOSE: An external use composition containing a complex crude drug extract including persimmon leaves is provided to prevent alopecia and to promoting hair growth without side effects and toxicity. CONSTITUTION: A pharmaceutical composition for external use for preventing alopecia, suppressing dandruff, and promoting hair growth contains a Morus alba leaf extract or a complex crude drug extract including mulberry leaves, Paeonia japonica Miyabe and Takeda, Diospyros kaki Thunberg calyx, ginkofolium, ginseng, cnidium, and mulberry as an active ingredient. The extract is prepared using water including purified water, spirit, C1-C4 alcohol, or a mixture solvent thereof. [Reference numerals] (AA) Control group; (BB) 3-rd group;

Description

Topical composition comprising the herbal mixed extract including persimmon leaf showing hair-growth stimulating activity and preventing effect on hair loss}

The present invention relates to an external composition having a hair loss prevention and hair growth promoting effect of the composite herbal extract (B), and more specifically, to the complex herbal extract (B) of the upper leaf, the white peach, the body, the encyclopedia, ginseng, the celestial organ, and the mulberry fruit. The present invention relates to a skin external pharmaceutical composition and a cosmetic composition having a hair growth effect in the experiment using a mouse and having a hair loss prevention and hair growth promoting effect.

1 Paus et al., J Invest Dermatol. 113, pp. 523-532, 1999

Document 2 Folia Pharmacol. Jpn. (Nippon Yakurigaku Zasshi) 119 (3), 167-174 (2002)

[Document 3] Korean Patent No. 0157667 (1998. 07. 31)

[Document 4] Republic of Korea Patent No. 0161338 (1998. 08. 24)

[Document 5] Korean Patent No. 259037 (2000. 03. 16)

[Document 6] Korean Patent No. 0260673 (2000. 04. 11)

[Ref. 7] Jung-Seop Shin and Shin Min-kyo, Hyang-Yak Dictionary, p.992, Younglimsa, 1998

[Ref. 8] Jung-seop Jung and Shin Min-kyo, Hyangjeomsa Dictionary, p.418, Younglimsa, 1998

[Ref. 9] Jung-seop Shin and Shin Min-kyo, Hyangjeomsa Dictionary, p.278, Younglimsa, 1998

[Ref. 10] Information Sub and Shin Min-kyo, Hyang-Yaksa Dictionary, pp.318-319, Younglimsa, 1998

[Document 11] Jung-Seop Shin and Min-Kyo Shin, Hyang-Yaksa Dictionary, pp.1039-1040, Younglimsa, 1998

[Document 12] Doosan Encyclopedia, Encyclopaedia, Modern Herbal Medicine, Hakchangsa

Document 13 Seok-Seon Rho et al., Journal of Dermatological Science , 38, pp.89-97, 2005

In recent years, the number of hair loss patients due to various chemicals and stress is rapidly increasing, which has a small impact on health as a medical disease, but causes a great aesthetic and psychological pain for the patient himself. Alopecia manifests in various forms, ranging from mild hair thinning to complete baldness, telogen effluvium, drug side effects, medical illness symptoms, tinea capitis, alopecia areata, trauma. It appears in various forms due to various causes such as alopecia, hereditary baldness, and androgenetic alopecia.

The number of hairs on the human body is about 5 million, of which about 100,000 hairs are on the head. The hair is composed of three layers of medulla, cortex, and hair. Hair does not grow for a lifetime, but grows naturally over a period of time. For hair, about 70 to 80 drops per day. The growth cycle of hair is usually divided into growth phase, degenerative phase, and resting phase, and the period varies depending on the part of the body. The hair is 85% growing and usually lasts 5-7 years. The degenerative hair is about 2% and begins to fall off after 2-3 weeks of rest (Paus et al., J Invest Dermatol. 113, pp. 523-532, 1999).

This process begins by hair papilla cells consisting of the dermis stimulate the mosquito matrix cells. Growth of insulin like growth factor (IGF-1), hepatocyte growth factor (HGF), and vascular endotherial growth facter (VEGF) found to be secreted from dermal papilla cells It is thought that the extracellular matrix, which is involved in cell migration and differentiation, promotes hair growth by increasing the amount during the factor and growth phase and decreasing it in the degenerative phase. In alopecia areata, electron microscopic observation of dermal papilla cells shows that the shape and nucleus are deformed and pigment granules or phobias are formed in the cytoplasm. These changes occur before the change of the hair is observed. It can be said that it starts from the change of cells (Folia Pharmacol. Jpn. (Nippon Yakurigaku Zasshi) 119 (3), pp. 167-174 (2002)).

Among the conventional hair growth promoting drugs for treating such alopecia, oral finasteride (Finasteride, Merk, USA) and external preparation minoxidil (Minoxidil, Upjohn, USA). Minoxidil has a capillary dilation function that prevents hair loss by applying it to the scalp, but it must be applied twice a day continuously, and only after the drug stays on the scalp for 3 to 4 hours for some effect. In terms of the effect is inadequate, side effects such as itching, irritation appear. Finasteride (Finasteride) has the effect of inhibiting the production of 5α-dihydrotestosterone (DHT), a male hormone that causes hair loss, and is known to show hair growth or hair loss inhibitory effects when taken for 6 months to 1 year. There was a problem returning to the original state. In addition, side effects may include decreased sexual function, such as decreased libido, erectile dysfunction, etc. Women are known to not take because of the risk of birth defects.

There have also been many attempts to promote hair growth by applying or taking herbal medicines to the scalp, using the extract of orchid plants (Korean Patent No. 0157667), and using the wormwood and mandrel (Korean Patent No. 0161338). ), Half, clove, Bokbunja, Sancho, Manza, Dansam and white porcelain (Korean Patent No. 259037), mungbean flour, soybean flour, black rice flour, perilla sesame powder, sesame powder, walnut powder, laver powder, mussel powder, Oyster powder, anchovy powder, seaweed powder, kelp powder, yeast concentrate, or a mixture of dried powder thereof (Korean Patent No. 0260673) has been published, but its principle of action is not clear and its efficacy has not been sufficiently verified. to be.

As described above, the above-mentioned hair restorers have problems such as economic burdens and pains to hair loss patients or cause side effects, use of only temporary or fragmentary pharmacological mechanisms, and the effects are more excellent and persistent. There is a growing demand for drugs that do not have side effects.

The leaves of the mulberry (Moraceae) are the leaves of the mulberry (Moraceae) and the related plant of the same family.The leaves are rutin, quercetin, isoquercetin, and moracetin. ), And it is known to have antidiabetic effects (information interviewer, Younglim Publishing Co., pp. 545-546, 1998).

Japak (Jakyak, Paeonia japonica) refers to the roots of the peony and the same root plant belonging to the Paeoniaceae family. Paeoniflorin, essential oils, fatty oils, tannins It is known as the main ingredient, and it has been known that it has an effect of jingyeong, analgesic, and antibacterial effect (Information Counselor, Younglim Publishing Co., pp. 524-525, 1998).

Carcass (= persimmon leaf) refers to the mature fruit of the Diospyros kaki Thunb belonging to the Scrophulariaceae, and the components include hydroxytriterpenoic acid, oleanolic acid and betulic acid. , Ursolic acid and other ingredients are known, and severe nausea and vomiting inhibitory effects are known (information interviewer, Younglim Publishing Co., pp. 915-916, 1998).

Encyclopedia (Ginkgo biloba) is a leaf of Ginkgo biloba L belonging to Ginkgoaceae, and its components include isorhamnetin, kaempherol, and kaemperol-3-rhamnoglucose. Seeds (kaempherol-3-rhamnoglucoside), quercetin, rutin, etc. are known, and the effects of cerebrovascular improvement, intestinal muscles and anti-cholesterol are known. .122-124, 1998).

Ginseng (Panax ginseng CA Meyer) is a perennial herb native to Korea, and processed ginseng manufactured by washing and drying several times of steamed ginseng and several steaming and drying processes is called red ginseng. Ginsenosides (ginsenosde) Rb1, Rc, Distilled oils such as at least 13 kinds of ginsenosides (saponins) and panaxynols, which are classified into protopanaxadiol (diol) and protopanaxatriol (triol) such as Rg1. It contains vitamins, enzymes such as organic acids, esters, sterols, nitrogen compounds, and folic acid, and is known to have a wide variety of effects such as central nervous system regulation, endocrine and metabolism regulation. , pp. 440-443, 1998).

The uterus is the root of the perennial herbaceous Cnidium officinale Makino, which belongs to the Umbelliferae, and its components include chnidilide, liqustilide, neocnidilide, and butylphthalide. butylphthalide) and other components are known, and the effects of peripheral blood vessel expansion and antibacterial activity are known (information interviewer, Younglim Publishing Co., pp. 418-419, 1998).

The mulberry (Morus alba L) fruit, which is native to the whole country, contains sugars, tannins, malic acid, carotene, linoleic acid, stearic acid, etc., and is known to be effective in beef, constipation, etc. Younglim Publishing Co., pp. 545-548, 1998).

Accordingly, the present inventors conducted an effort and research to find a raw material having excellent stability and hair growth improvement effect among the herbal extracts used as herbal medicines, and the complex herbal extracts of the upper leaf, the white pear, the carcass, the encyclopedia, the ginseng, the cheongung, and the mulberry It was confirmed that the hair loss prevention, dandruff suppression and hair growth improvement effect has been completed the present invention.

In order to carry out the above object, the present invention is an external skin having anti-hair loss, dandruff suppression and hair growth promoting effect containing a compound herbal extract of the upper leaf extract or the upper leaf, earl, corpse, encyclopedia, ginseng, cheongung, Audi as an active ingredient It provides a pharmaceutical composition.

The present invention provides a cosmetic composition having a hair loss prevention, dandruff suppression and hair growth promoting effect containing an extract of the upper leaf or the upper leaf, white pear, carcass, encyclopaedia, ginseng, Cheongung, mulberry as an active ingredient.

The extract as defined herein includes water, spirits, lower alcohols having 1 to 4 carbon atoms or mixed solvents thereof, preferably extracts, including water, including purified water.

Complex herbal extract of the present invention is the compound weight ratio of the composite herbal extracts of the upper leaf, earl, corpse, encyclopaedia, ginseng, cheongung, Audi 1-10: 1-10: 1-10: 1-10: 1-10: 1 Weight ratio (w / w) of 1-10: 1-10, Preferably 1-5: 1-5: 1-5: 1-5: 1-5: 1-5: 1-5 weight ratio (w / w) ), More preferably 1 to 2: 1 to 2: 1 to 2: 1 to 2: 1 to 2: 1 to 2: 1 to 2, characterized in that the weight ratio (w / w).

The external skin pharmaceutical composition includes a cream, gel, patch, spray, ointment, warning, lotion, linen, pasta or cataplasma formulation.

In addition, the cosmetic composition is a hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair moisturizer cream, hair massage cream, hair wax, Hair aerosol, hair pack, hair nutrition pack, hair soap, hair cleansing foam, hair oil, hair drier, hair preservative, hair dye, hair wave agent, hair bleach, hair gel, hair glaze, hair dresser, hair lacquer, hair moisturizer Formulations of risers, hair mousses or hairsprays.

The cosmetic composition is a hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair moisturizing cream, hair massage cream, hair wax, hair aerosol , Hair pack, nourishment pack, hair soap, hair cleansing foam, hair oil, hair drier, hair preservative, hair dye, hair wave, hair bleach, hair gel, hair glaze, hair dresser, hair lacquer, hair moisturizer, Formulations of hair mousse or hairspray.

Hereinafter, a method of obtaining the upper leaf extract or the composite herbal extract of the present invention will be described in detail.

The herbal extract of the present invention washes and cuts the complexes of the upper leaf, the white leaf, carcass, the encyclopedia, ginseng, the celestial organ, and the mulberry, 1 to 10: 1 to 10: 1 to 10: 1 to 10: 1 to 10: 1 to 10: 1 to 10 weight ratio (w / w), preferably 1 to 5: 1 to 5: 1 to 5: 1 to 5: 1 to 5: 1 to 5: 1 to 5 weight ratio (w / w), more preferably 1 to 2: 1 to 2: 1 to 2: 1 to 2: 1 to 2: 1 to 2 : First step of mixing in a weight ratio (w / w) of 1 to 2; Water, alcohol, C ₁ to C ₄ lower alcohols or mixed solvents thereof containing about 1 to 100 times (w / w), preferably 50 to 70 times (w / w) purified water, of the total weight thereof. , Preferably 1 to 10 times, preferably 2 to 5 times at 40 ° C. to 160 ° C., preferably 80 ° C. to 120 ° C. for 1 to 10 hours, preferably 2 to 6 hours by adding water. Extraction method such as extraction, hot water extraction, ultrasonic extraction, reflux cooling extraction, preferably extracted by hot water extraction method and then lyophilized to concentrate through the step of the extract of the upper leaf of the present invention or the upper leaf, white medicinal herbs, encyclopedia, ginseng, cheongung It is possible to obtain a complex herbal extract of Audi.

The present invention provides a pharmaceutical composition and cosmetic composition for external skin having anti-hair loss, anti-dandruff and hair growth promoting effect containing the extract of the upper leaf or complex herbal extract obtained by the production method as an active ingredient.

The herbal extract obtained by the extraction method was confirmed to exhibit hair loss prevention, dandruff prevention, hair growth promotion and hair growth effects through animal hair experiments.

The composition having a hair loss prevention and hair growth promoting effect of the present invention comprises 0.1 to 50% by weight of the composite herbal extract based on the total weight of the composition.

However, the composition is not limited thereto, and may vary depending on the condition and progress of the patient.

The skin external pharmaceutical composition containing the complex herbal extract of the present invention as an active ingredient is a skin external preparation having a hair loss prevention and hair growth promoting effect, such as a cream, a gel, a patch, a spray, an ointment, a warning, a lotion, a lining agent, and a pasta agent. Or it can be prepared and used as a pharmaceutical composition in the form of an external preparation for skin of cataplasmase, but is not limited thereto.

The preferred dosage of the complex herbal extract of the present invention depends on the condition and body weight of the patient, the extent of the disease, the form of the drug, the route of administration and the duration, and may be appropriately selected by those skilled in the art. However, for the desired effect, the cypress phytoncide-containing complex herbal extract of the present invention is preferably administered at 0.0001 to 100 mg / kg, preferably at 0.001 to 10 mg / kg. The administration may be carried out once a day or divided into several times. The dose is not intended to limit the scope of the invention in any way.

In addition, the composition containing the complex herbal extract of the present invention as an active ingredient can be used in various hair cosmetics having a hair loss prevention and hair growth promoting effect. Examples of products to which the composition can be added include, for example, hair tonics, hair conditioners, hair essences, hair lotions, hair nutrition lotions, hair shampoos, hair rinses, hair treatments, hair creams, hair nutrition creams, hair moisturizers. Cream, hair massage cream, hair wax, hair aerosol, hair pack, hair nutrition pack, hair soap, hair cleansing foam, hair oil, hair dryer, hair preservative, hair colorant, hair wave agent, hair bleach, hair gel, hair glaze, Cosmetics such as hair dressers, hair lacquers, hair moisturizers, hair mousses or hair sprays and the like.

The composition having the hair loss prevention, dandruff production inhibition and hair growth promoting effect of the present invention, 0.00001 to 50% by weight (w / w), preferably, 0.0001 to 20% by weight (w / w) of the composite herbal extract based on the total weight of the composition / w), more preferably 0.1 to 10% by weight (w / w).

However, the composition is not limited thereto, and may vary depending on the condition and progress of the patient.

The composition of the present invention can be used in a variety of hair cosmetics having hair loss prevention, dandruff production inhibition and hair growth promoting effect. Examples of products to which the composition can be added include, for example, hair tonics, hair conditioners, hair essences, hair lotions, hair nutrition lotions, hair shampoos, hair rinses, hair treatments, hair creams, hair nutrition creams, hair moisturizers. Cream, hair massage cream, hair wax, hair aerosol, hair pack, hair nutrition pack, hair soap, hair cleansing foam, hair oil, hair dryer, hair preservative, hair colorant, hair wave agent, hair bleach, hair gel, hair glaze, Cosmetics such as hair dressers, hair lacquers, hair moisturizers, hair mousses or hair sprays and the like.

Cosmetics of the present invention comprises a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids and seaweed extract.

The water-soluble vitamin is not particularly limited as long as it can be compounded in cosmetics. Preferably, vitamin B, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, And their salts (thiamine hydrochloride, sodium ascorbate, etc.) or derivatives (sodium ascorbic acid-2-phosphate, magnesium ascorbate-2-phosphate etc.) can also be added to water-soluble vitamins . The water-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification from microorganism culture, enzyme or chemical synthesis.

The oil-soluble vitamin may be any compound that can be formulated into cosmetics, but preferably vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol), and the like. And derivatives thereof (ascorbic palmitate, ascorbic stearate, ascorbic acid dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherolvitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, pantotenylethyl Ethers, etc.) are also included in the oil-soluble vitamins used in the present invention. Oil-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification of microorganism culture, enzyme or chemical synthesis.

The polymeric peptide may be any compound as long as it can be compounded in cosmetics, and examples thereof include collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, and keratin. Polymeric peptides can be purified and obtained by conventional methods such as purification from microbial cultures, enzymatic methods or chemical synthesis methods, or can be purified and used from natural products such as dermis and pig silk such as pigs and cattle.

The polymeric polysaccharide may be any compound as long as it can be incorporated in cosmetics, and examples thereof include hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or a salt thereof (sodium salt, etc.). For example, chondroitin sulfate or its salt, etc. can be normally purified from a mammal or fish.

The sphingolipid may be any compound as long as it can be blended into cosmetics. Preferably, ceramide, phytosphingosine, sphingosaccharide lipid, etc. may be mentioned. Sphingo lipids can usually be purified from mammals, fish, shellfish, yeasts or plants by conventional methods or obtained by chemical synthesis.

The seaweed extract may be any compound as long as it can be blended into cosmetics. Preferably, the seaweed extract may include brown algae extract, red algae extract, green algae extract, and the like. Also, calginine, arginic acid, sodium arginate, Potassium arginate and the like are also included in the seaweed extract used in the present invention. Seaweed extract can be obtained by purification from seaweed by conventional methods.

The cosmetic of the present invention may be blended with other essential ingredients, if necessary, in combination with the essential ingredients.

Other components that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, flavorings, Blood circulation accelerators, cooling agents, restriction agents, purified water and the like.

Examples of the fat or oil component include ester fats, hydrocarbon fats, silicone fats, fluorine fats, animal fats, and vegetable fats and oils.

As ester fats and oils, glyceryl tri2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl mystinate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, and stearic acid Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl acid isocetyl, isostyl acid isostearyl, isostaryl palmitate, octylate acid octyldodecyl, isostearic acid isetyl, diethyl sebacate, adipine Acid isopropyl, isoalkyl neopentane, tri (capryl, capric acid) glyceryl, trimethyl ethyl trimethylol propane, triisostearic acid trimethylol propane, tetra 2-ethylhexanoic penta erythritol Cetyl caprylate, lauric acid decyl, hexyl laurate, decyl myristin, myristin acid myristyl, myritic acid cetyl, stearyl stearate, decyl oleate, rininooleic acid , Isostearyl laurate, isotridecyl myristin, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecate oleate, octylate decyl oleate, octyl dodecyl linoleate, isopropyl isopropyl acid, 2 -Cetostearyl ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicapric acid, propylene glycol dicacapate, capric acid Propylene glycol, dicapric acid neopentyl glycol, dioctanoate neopentyl glycol, tricaprylic acid glyceryl, triundecyl glyceryl, triisopalmitinate glyceryl, triisostearate glyceryl, neopentane dodecyl Isostearyl octanoate, octyl isononate, hexyl decyl neodecanoate, octyl dodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, Sothete octylate, polyglycerol oleate, polyglycerine isostearate, triisocetyl citrate, triisoalkyl citrate, triisoctyl citrate, lauryl lactate, myritic lactate, octyl lactate, octyl lactate, tricitric acid Ethyl, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, diisostearyl malic acid, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipicate, diisopropyl sebacinate, Dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, physteryl isostearate, phytic oleate, 12-Steloylhydroxystearate isocetyl, 12-Steloylhydroxystearate stearyl, 12-stealo Esters such as monohydroxystearic acid isostearyl; and the like.

Hydrocarbon-based fats and oils, such as squalene, a liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, a liquid isoparaffin, polybutene, microcrystal wax, and a vaseline, etc. are mentioned as a hydrocarbon-type fats and oils.

Examples of the silicone-based oils and fats include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane, methylcetyloxysiloxane copolymer, dimethylsiloxane and methylsteoxysiloxane copolymer, and alkyl. Modified silicone oil, amino modified silicone oil and the like.

Examples of the fluorine-based oil include perfluoropolyether and the like.

Animal or vegetable fats and oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, soybean oil, soybean oil, corn oil, rapeseed oil, almond oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil, Cottonseed oil, palm oil, coukin nut oil, wheat germ oil, rice germ oil, shea butter, moon dog colostrum oil, marker demy nuts nut, meadow home oil, egg yolk oil, Uji, horse oil, mink oil, orange rape oil, jojoba oil, Animal or plant fats and oils, such as candeler wax, carnava wax, liquid lanolin, and hardened castor oil.

Examples of the moisturizing agent include a water-soluble low molecular moisturizer, a fat-soluble molecular moisturizer, a water-soluble polymer, and a fat-soluble polymer.

Water-soluble low molecular humectants include serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene Glycol (polymerization degree n = 2 or more), polyglycerol B (polymerization degree n = 2 or more), lactic acid, lactic acid salt, etc. are mentioned.

Examples of the fat-soluble low molecular humectants include cholesterol and cholesterol esters.

Examples of the water-soluble polymer include carboxyvinyl polymer, polyasparaginate, tragacanth, xanthan gum, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water soluble chitin, chitosan, and dextrin. Can be.

     Examples of the fat-soluble polymers include polyvinylpyrrolidone-eicosene copolymers, polyvinylpyrrolidone-hexadecene copolymers, nitrocellulose, dextrin fatty acid esters, polymer silicones, and the like.

Examples of the emollient include long-chain acyl glutamic acid cholesteryl esters, hydroxy stearic acid cholesterol, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl esters, and the like.

As surfactant, nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant, etc. are mentioned.

As nonionic surfactant, self-emulsifying glycerin monostearate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerol fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE Glycerin fatty acid ester, POE OE ether, POE fatty acid ester, POE hardened castor oil, POE castor oil, POE / POP (polyoxyethylene polyoxypropylene) copolymer, POE / POP alkyl ether, polyether modified silicone, lauric acid Alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, etc. are mentioned.

Anionic surfactants include fatty acid soaps, alpha-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates, alkylamide sulfates, alkyl phosphates, POE alkylphosphates, and alkylamides. Phosphates, alkyloylalkyltaurine salts, N-acylamino acid salts, POE alkyl ether carboxylate salts, alkyl sulfosuccinate salts, sodium alkyl sulfo acetates, acylated hydrolyzed collagen peptide salts, perfluoroalkyl phosphate esters, and the like. have.

     As cationic surfactant, alkyl trimethylammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, cetostearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl benzyl ammonium bromide, behenyl trimethyl ammonium chloride, chloride Benzalkonium, diethylaminoethyl stearate, dimethylaminopropyl stearate, lanolin derivatives, quaternary ammonium salts, and the like.

     Examples of amphoteric surfactants include the carboxybetaine type, the amide betain type, the sulfobetain type, the hydroxysulfobetain type, the amide sulfobetain type, the phosphobetaine type, the aminocarboxylate type, the imidazoline derivative type, and the amideamine type. An amphoteric surfactant etc. are mentioned.

Examples of the organic and inorganic pigments include inorganic pigments such as silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, Bengala, clay, bentonite, titanium mica, titanium oxide, bismuth chloride, zirconium oxide, magnesium oxide, Inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, chromium oxide, chromium oxide, chromium hydroxide, Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene, styrene copolymer, Organic pigments such as silk powder, cellulose, CI pigment yellow, CI pigment orange, and composite pigments of these inorganic pigments and organic pigments;

As organic powder, Metal soaps, such as a calcium stearate; Alkyl phosphate metal salts such as sodium cetylinate, zinc lauryl acid and calcium laurate; Acylamino acid polyvalent metal salts such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroylglycine calcium; Amide sulfonic acid polyvalent metal salts, such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N-epsilon-lauroyl-L-lysine, N-epsilon-palmitolyzine, N-alpha-paratoylol nitin, N-alpha-lauroyl arginine, N-alpha-cured fatty acid acyl arginine -Acyl basic amino acid; N-acyl polypeptides, such as N-lauroyl glycyl glycine; Alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; Polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene-styrene copolymer, ethylene tetrafluoride and the like.

Examples of the ultraviolet absorber include paraaminobenzoic acid, ethyl paraaminobenzoate, amyl paraaminobenzoic acid, octyl paraaminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomentyl salicylic acid and benzyl cinnamic acid. , Paramethoxy cinnamic acid-2-ethoxyethyl, paramethoxy cinnamic acid octyl, diparamethoxy cinnamic acid mono-2-ethylhexaneglyceryl, paramethoxy cinnamic acid isopropyl, diisopropyl diisopropyl cinnamic acid ester mixture, wuro Canonic acid, ethyl urokanoate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and salts thereof, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium sulfonate, dihydroxybenzophenone , Tetrahydroxybenzophenone, 4- tert -butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino- p- (carbo-2'-ethylhexyl-1'-oxy) -1 , 3,5-triazine, 2- (2-hi And the like can be mentioned hydroxy-5-methylphenyl) benzotriazole.

Examples of the disinfectant include hinokitiol, trichloroacid, trichlorohydroxydiphenyl ether, crohexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zinc filitione, benzalkonium chloride, No. 301, mononitro and eicol sodium, and undecylenic acid.

Examples of the antioxidant include butylhydroxyanisole, propyl gallic acid, and erythorbic acid.

Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fmaric acid, sodium pmarate, succinic acid, sodium succinate, sodium hydroxide, sodium dihydrogen phosphate, and the like.

Examples of the alcohol include higher alcohols such as cetyl alcohol.

Moreover, the compounding component which may be added other than this is not limited to this, Although any said component can be mix | blended within the range which does not impair the objective and effect of this invention, Preferably it is 0.01 to 5% weight percentage with respect to a total weight, More Preferably in an amount of 0.01 to 3% by weight.

The cosmetic of the present invention may take the form of a solution, an emulsion, a viscous mixture or the like.

Components included in the cosmetic composition of the present invention may include components commonly used in cosmetic compositions in addition to the complex herbal extract as an active ingredient, for example, such as stabilizers, solubilizers, vitamins, pigments and flavorings Phosphorus aids and carriers.

The cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, and includes, for example, milky lotion, cream, lotion, pack, foundation, lotion, essence, hair cosmetic, and the like.

When the formulation of the present invention is a paste, cream or gel, animal fiber, plant fiber, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane or dimethyl ether.

In the case of the solution or emulsion of the present invention, a solvent, a solvent or an emulsifier is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

Hair loss prevention and hair growth promoting composition containing a composite herbal extract of the present invention has no side effects or toxicity to the human body, bar hair loss prevention, dandruff prevention, hair growth promotion and hair growth through the hair growth animal experiments, hair loss prevention It can be usefully used as an external skin pharmaceutical composition and cosmetic composition that exhibits an effect of inhibiting dandruff and promoting hair growth.

1 is a diagram showing the hair growth effect of the mice coated with the composite herbal extract (B) of the present invention (group 1-mulberry leaf hydrothermal extract, group 3-mulberry leaf, baekjak, persimmon leaf, ginkgo biloba, ginseng, cheongung and Audi complex hydrothermal Extracts, group 6-audio, sewage, celery, chrysanthemum, saenghwang and mulberry leaf complex hydrothermal extract).

Hereinafter, the present invention will be described in detail with reference to the following examples and experimental examples.

However, the following examples and experimental examples are illustrative of the present invention, and the content of the present invention is not limited by the following examples and experimental examples.

Example  One. Upper lobe  Preparation of Extract (B)

150 g of the leaves obtained from Dong Hoon Food Industries (Buan, www.buanmall.co.kr) were washed and chopped, and placed in a mechanical shaker, respectively, 10 kg of water was added thereto, and extracted twice at 100 ° C. for 3 hours. Then, lyophilized and concentrated to 50% mulberry leaf hot water extract (hereinafter, each named "A"), was used as a sample of the following experimental example.

Example  2. Preparation of Complex Herbal Extract (B)

25g, persimmon leaf 25g, ginkgo leaf 25g, ginseng 25g, Cheongung 25g and Donghoon Food Industries (Buan, www.buanmall.co.kr) purchased from OmniHerb (www.omniherb.com) 25 g of the purchased mulberry and 25 g of the upper leaves were washed and shredded into a mechanical shaker, respectively, and 10 kg of water was added thereto, followed by extracting twice at 100 ° C. for 3 hours, lyophilizing and concentrating to 50%. Hot water extract and mulberry leaf, earl pear, persimmon leaf, ginkgo biloba, ginseng, Cheongung and Audi composite hot water extract (hereinafter referred to as "B"), was used as a sample of the following experimental example.

Experimental Example  1. Experiment of hair growth promoting effect using mouse

The method of Rho et al. (Seok-Seon Rho et al. To investigate the hair growth promoting effect of the mulberry leaf hot water extract (A) and the mulberry leaf, earl pear, persimmon leaf, ginkgo biloba, ginseng, cheonggung and mulberry composite hot water extract (B) obtained in the above examples. al., Journal of Dermatological Science , 38, pp. 89-97, 2005).

1-1. Preparation for experiment

Six-week-old mice (C57 / BL6, Orient, Korea, 18 to 20 g) were allowed to acclimate in the nursery for one week before the telogen period, and then the mice were anesthetized (ketamine or pentobalbital, Hallym Pharm., Entoval. 70601) was administered intraperitoneally (2.5 mg / individual) to anesthetize. Anesthetize the rat's back with 1 g of a depilatory agent (Ildong Pharmaceutical, Niklin), spread it out well, leave it at room temperature for about 2 minutes, and remove it with a scraper. Haired rats are washed with lukewarm water to remove excess hair. In order to verify the effect of the composite herbal extract (A, B) obtained in the above example, the rats were divided into 5 groups and the sample material was applied once daily for 20 days (2% minoxidil: 0.1 ml, A: 0.3 ml) The negative control group was minoxidil solvent (alcohol: water: PEG400 = 60: 20: 20), the positive control group was 2% minoxidil, and the experimental group was complex herbal extract (A, B).

1-2. Observe the hair growth effect

In order to observe the hair growth effect of the mice divided into 5 groups using the composite herbal extracts (A, B) obtained in the above example, photographs were taken on the 5th, 8th, 12th, 16th and 22nd days. The degree of hair growth progress was observed.

As shown in FIG. 1, since the 7-week-old mice were telogen, which is a natural hair loss period, the skin of the back of the hair was white after depilation, and the change in the negative control group, the positive control group, or the experimental group was clear until the 5th day. Was not observed, but hair follicle growth was observed in the back of mice treated with minoxidil and complex herbal extracts (A, B). After 5 days, the hair growth of the mice was different according to the experimental group. On the 12th day, almost 70% of hair growth was observed in the back of the group treated with the herbal extracts (A, B), which is a representative hair growth promoting drug. It was confirmed that the results were similar to the well-known positive control treated minoxidil. After 12 days, hair growth progressed rapidly in almost all the mouse groups, and at day 22, complete hair growth was observed in all groups.

From the results of the experiment it was confirmed that the complex herbal extract (A, B) is effective in hair growth. The effects of the combined herbal extracts (A, B) were found to be similar to the minoxidil in the appearance of hair follicles on the 5th day and the growth of hair growth on the 12th day.

1-3. Measurement of hair density and thickness

Color video imaging device (Leadm, Korea) and polyscope (Leadm, Korea) were used for the hair density and thickness of mice divided into 5 groups using the composite herbal extracts (A, B) obtained in Example 1 as samples. It was measured by.

As a result of measuring the density of the hair, as shown in Table 1 below, the hair density of the group treated with the complex herbal extracts (A, B) at day 12 showed a similar density level to that of the positive control treated with minoxidil, which was negative control. It was confirmed that the higher than.

In addition, as a result of measuring the thickness of the hair, as shown in Table 2, it was confirmed that the hair thickness of the group treated with the composite herbal extracts (A, B) on the 12th day showed a similar thickness to the positive control group treated with minoxidil. .

Day 12
(Number / cm ²⁾ Day 22
(Number / cm ²⁾   Negative control group  525 ± 297  5,180 ± 484   Positive control group (minoxidil treatment group)  4,095 ± 420  7,035 ± 931   Complex herbal extract (A) treatment group  3,780 ± 242  6,300 ± 594   Complex herbal extract (B) treatment group  3,570 ± 41  5,460 ± 484

  Hair Removal (mm)    Day 12 (mm)    Day 22 (mm)   Negative control group 0.030 ± 0.008 0.029 ± 0.007 0.027 ± 0.006   Positive control group (minoxidil treatment group) 0.031 ± 0.006 0.014 ± 0.005 0.047 ± 0.006   Complex herbal extract (A) treatment group 0.026 ± 0.007 0.046 ± 0.004 0.045 ± 0.013   Complex herbal extract (B) treatment group 0.036 ± 0.009 0.048 ± 0.003 0.050 ± 0.006

Hereinafter, the preparation examples of the composition including the extract of the present invention, but the present invention is not intended to limit it, but is intended to explain in detail only.

Formulation example  1. Manufacture of hair tonic

Resorcinol 0.1%

Menthol 0.05%

Panthenol 0.2%

Salicylic Acid 0.1%

Tocopheryl Acetate 0.1%

Pyridoxine hydrochloride 0.1%

Castor Oil 5.0%

Complex herbal extract (B) 10.0%

Pigment amount

Spices

Ethanol

Purified water level

Total 100.0%

Formulation example  2. Hair Conditioner  Produce

Cetanol 3.5%

Self-emulsifying glycerin monostearate 1.5%

Propylene Glycol 2.5%

Stearylmethylbenzyl Ammonium Chloride (25%) 7.0%

0.3% methyl paraoxybenzoate

Complex herbal extract (B) 2.5%

Pigment amount

Spices

Purified water level

Total 100.0%

Formulation example  3. Hair lotion  Produce

Resorcinol 2.0%

Menthol 2.0%

Panthenol 0.5%

Pyroctonolamine 0.1%

Complex herbal extract (B) 5.0%

Fragrance, pigment 0.5%

Purified water level

Total 100.0%

Formulation example  4. Hair soap  Produce

Complex herbal extract (B) 0.1%

Titanium dioxide 0.2%

Polyethylene Glycol 0.8%

Glycerin 0.5%

Ethylenediaminetetraacetic Acid 0.05%

Sodium 1.0%

Pigment amount

Soap flavor

Cosmetic soap base (13% moisture, parts by weight)

Total 100.0%

Formulation example  5. Hydrophilic Ointment

Complex herbal extract (B) 0.5%

250% white petrolatum

Stearyl Alcohol 220%

Ethyl (or methyl) p-oxybenzoate 0.25%

Propylene Glycol 120%

Sodium Lauryl Sulfate 15%

Propyl p-oxybenzoate 0.15%

Claims (8)

A skin external pharmaceutical composition having a hair loss prevention, dandruff suppression, and hair growth promoting effect, which contains a compound herbal extract of an upper leaf extract or an upper leaf, an ear cut, a body, an encyclopedia, ginseng, a celestial organ, and an organ as an active ingredient.
The method of claim 1,
The extract is an external skin pharmaceutical composition, characterized in that the extract is available in water, spirits, lower alcohols having 1 to 4 carbon atoms or a mixed solvent thereof, including purified water.
The method of claim 1,
The blending ratio of the complex herbal extracts of the upper lobe, earl pear, carcass, encyclopedia, ginseng, cheongung, and Audi is 1-10: 1-10: 1-10: 1-10: 1-10: 1-10: 1-10 Skin composition for external skin, characterized in that the weight ratio (w / w).
The external skin pharmaceutical composition is a cream, gel, patch, spray, ointment, warning agent, lotion, lining agent, pasta or cataplasma formulations characterized in that the external skin pharmaceutical composition.
A cosmetic composition having anti-hair loss, anti-dandruff, and hair growth promoting effect, which contains a complex herbal extract of an upper leaf extract or an upper leaf, an ear cut, a corpse, an encyclopedia, ginseng, a celery, an audi.
6. The method of claim 5,
The extract is a cosmetic composition, characterized in that the extract is available in water, spirits, lower alcohols having 1 to 4 carbon atoms or a mixed solvent thereof, including purified water.
6. The method of claim 5,
The blending ratio of the complex herbal extracts of the upper lobe, earl pear, carcass, encyclopedia, ginseng, cheongung, and Audi is 1-10: 1-10: 1-10: 1-10: 1-10: 1-10: 1-10 Cosmetic composition, characterized in that the weight ratio (w / w).
6. The method of claim 5,
The cosmetic composition is a hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream, hair nutrition cream, hair moisturizing cream, hair massage cream, hair wax, hair aerosol , Hair pack, nourishment pack, hair soap, hair cleansing foam, hair oil, hair drier, hair preservative, hair dye, hair wave, hair bleach, hair gel, hair glaze, hair dresser, hair lacquer, hair moisturizer, Cosmetic composition which is a formulation of hair mousse or hairspray.

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