KR100834108B1 - Composition for preventing falling out of the hair and promoting growth of the hair - Google Patents

Composition for preventing falling out of the hair and promoting growth of the hair Download PDF

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KR100834108B1
KR100834108B1 KR1020070005382A KR20070005382A KR100834108B1 KR 100834108 B1 KR100834108 B1 KR 100834108B1 KR 1020070005382 A KR1020070005382 A KR 1020070005382A KR 20070005382 A KR20070005382 A KR 20070005382A KR 100834108 B1 KR100834108 B1 KR 100834108B1
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extract
weight
parts
hair
composition
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KR1020070005382A
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이은상
강대순
강은진
강성훈
김용희
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(주)주환바이오.셀
주식회사 일진코스메틱
김용희
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02Algae
    • A61K36/04Rhodophycota or rhodophyta (red algae), e.g. Porphyra
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538Schizonepeta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9711Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

A composition is provided to show hair loss preventing effect and hair growth effect without causing any side effects even for a long use time, thereby being usefully applied as a cosmetic for preventing the hair loss and promoting the hair gross. A composition for preventing hair loss and promoting hair growth comprises 5-15 parts by weight of an extract of Panax ginseng C.A Meyer, 4-5 parts by weight of an extract of Saposhnikovia divaricata Schiskin, 2-5 parts by weight of an extract of Schizonepeta tenuifolia, 0.5-15 parts by weight of an extract of baicalin extracted from Scutellaria baicalensis, 1-5 parts by weight of an extract of Sophora flavescens, 0.1-5 parts by weight of an extract of Glycyrrhiza uralensis, 0.5-5 parts by weight of an extract of Angelica gigas Nakai, 5-15 parts by weight of an extract of Porphyra tenera, 0.5-5 parts by weight of an extract of Pleuropterus multflorus, 10-20 parts by weight of an extract of Cimicifuga davurica maxim roots, and 1-5 parts by weight of an extract of Perilla frutescens var. acuta kudo. Further, the extract of Panax ginseng C.A Meyer, the extract of Saposhnikovia divaricata Schiskin, the extract of Sophora flavescens, the extract of Pleuropterus multflorus and the extract of Perilla frutescens var. acuta kudo are extracted from a mixture solvent of water and ethanol which is mixed at a weight ratio of 1:1 to 10.

Description

탈모 방지 및 모발 성장 촉진용 조성물{Composition for preventing falling out of the hair and promoting growth of the hair}Composition for preventing falling out of the hair and promoting growth of the hair}

도 1 본 발명에 따른 조성물에 함유되는 바이칼린의 구조 및 1H NMR 스펙트럼을 나타낸 것이고,Figure 1 shows the structure and 1 H NMR spectrum of Baikal contained in the composition according to the present invention,

도 2는 본 발명에 따른 조성물에 함유되는 바이칼린의 HPLC 분석결과를 나타낸 것으로 (a)는 표준물질, (b)는 본 발명의 제조예에서 제조된 물질의 결과이며,Figure 2 shows the results of HPLC analysis of the baccalin contained in the composition according to the present invention (a) is a standard material, (b) is a result of the material prepared in the preparation of the present invention,

도 3은 본 발명의 실험예 2에 따른 발모 촉진 효능을 나타낸 사진이고,Figure 3 is a photograph showing the hair growth promoting effect according to Experimental Example 2 of the present invention,

도 4는 본 발명의 실험예 3에 따른 피부절편에서의 모근 세포 활성 효과를 나타낸 사진으로 (a)는 용매대조군, (b)는 제조예 9 추출물(10중량%), (c)는 제조예 9 추출물(5중량%), (d)는 미녹시딜(5중량%)로 처리한 결과이다.Figure 4 is a photograph showing the hair root cell activity effect in the skin section according to Experimental Example 3 of the present invention (a) is a solvent control group, (b) Preparation Example 9 extract (10% by weight), (c) is a preparation example 9 extract (5% by weight), (d) is the result of treatment with minoxidil (5% by weight).

본 발명은 탈모 방지 및 모발 성장 촉진용 조성물에 관한 것이다The present invention relates to a composition for preventing hair loss and promoting hair growth.

모발은 외부의 자극으로부터 완충작용과 자외선, 온도, 마찰 등 외부 자극으로부터 인체를 방어와 보호 작용을 하며, 신체에 불필요한 비소, 수은, 아연 등의 중금속을 흡수하여 체외로 배출하는 기능을 가지고 있으며, 외적 이미지 표현에 중요한 미적요소가 된다.Hair protects and protects the body from external stimuli such as buffering and external stimuli such as ultraviolet rays, temperature, and friction, and absorbs heavy metals such as arsenic, mercury, and zinc that are unnecessary to the body and releases them to the body. It is an important aesthetic factor in the expression of external images.

모발은 포유동물만이 가지고 있으며 피부의 부속기관으로서 모발의 발생은 태생 9 ~ 12주부터 시작되고, 부모의 유전성을 받아 계승하고 있다. 털은 모낭(follicle)에서 자란다. 모발은 모주기(hair cycle)에 따라 성장기(anagen), 퇴행기(catagen), 휴지기(telogen)의 3주기로 나누어지는데 모발은 성장기에만 성장하고 각각의 모발의 성장주기는 독립적이며, 독자적인 주기를 가지므로 일시에 전모가 탈락하는 일은 없다. 휴지기의 모발은 하루에 70~120개 정도이며 매일 자연스럽게 탈락되며, 모발의 주기는 성장기 5~6년, 퇴행기 2~3주간, 휴지기는 2~3개월 정도로 구분된다. 모발의 성장은 개체의 영양상태, 호르몬 온도 일관 분만 전신 및 질환, 각종 화학물 등 여러 가지 내외적 요인에 의해 영향 받으며 특히 어떤 원인에 의해 두피의 표피 과발육이 일어나는 경우에는 휴지기의 모발을 활성화시키는 것으로 알려져 있다. Hair is only a mammal, and as an appendage to the skin, hair development starts from 9 to 12 weeks of birth and is inherited by parental inheritance. Hair grows in follicles. The hair is divided into three periods according to the hair cycle (anagen, catagen, and telogen). Hair grows only in the growth phase, and each hair growth cycle is independent and has its own cycle. The whole picture does not fall off at one time. During the resting period, there are 70 to 120 hairs per day, and naturally drop out every day. Hair cycles are divided into five to six years of growth, two to three weeks of degeneration, and two to three months of rest. Hair growth is influenced by various internal and external factors, such as nutritional status of the individual, hormonal temperature consistent systemic and disease, and various chemicals. Especially, when the epidermal overgrowth of the scalp is caused by some cause, It is known.

요즈음 환경적 유전적 정신적 신체적 등 여러 가지 원인으로 신체적 리듬이 깨져 밸런스가 맞지 않아 두피뿐만 아니라 모낭도 크게 영향을 받고 있다. 이로 인해 모발손상은 기본이며, 건조하거나 민감해져, 탈모 등 여러 가지 형태로 나타나고 있다.These days, the physical rhythm is broken due to various causes such as environmental, genetic, mental, and physical, and the hair follicles as well as the scalp are greatly affected. Because of this, hair damage is basic, and it becomes dry or sensitive, and it appears in various forms such as hair loss.

이에 따라 탈모를 비롯한 각종 두피 및 모발의 이상 증상을 방지하여 두피 및 모발의 상태를 개선시킬 수 있는 조성물에 대한 연구가 진행되어 왔다. 이러한 조성물은 모발의 탈모 방지효과, 발모효과, 양모효과가 우수하게 나타내어야 한다.Accordingly, research has been conducted on compositions that can improve the condition of the scalp and hair by preventing abnormalities of various scalp and hair including hair loss. Such compositions should exhibit excellent hair loss prevention, hair growth, and wool effects.

또한 두피 및 모발에 사용되는 조성물의 제품은 장기간 빈번하게 사용하므로 자극이나 손상 등의 부작용을 나타내지 않아야 한다. 그러나 기존에 시판중인 관련제품들은 기대 수준의 두피 및 모발의 개선효과를 나타내기에는 미흡하며, 주성분이 화학물질인 경우가 많아 두피에 부작용을 유발하는 경우가 많다.In addition, since the product of the composition used for the scalp and hair is frequently used for a long time, it should not show side effects such as irritation or damage. However, related products on the market are insufficient to show the expected improvement of the scalp and hair, and the main ingredient is often a chemical, which often causes side effects on the scalp.

따라서, 탈모 방지 및 모발 성장 촉진 효과가 우수하며 장기간 사용에도 부작용이 전혀 없는 탈모 방지 및 모발 성장 촉진용 조성물의 개발이 필요한 실정이다.Therefore, there is a need for the development of a composition for preventing hair loss and promoting hair growth that is excellent in preventing hair loss and promoting hair growth and having no side effects even in long-term use.

본 발명의 목적은 탈모 방지 및 모발 성장 촉진 효과가 우수하며 장기간 사용에도 부작용이 전혀 없는 탈모 방지 및 모발 성장 촉진용 조성물을 제공하는 것이고, 특히 두피의 모낭 세포의 활성화를 통해 모발 성장 촉진 효과가 우수하며, 천연물질에서 유래된 성분만을 사용하여 장기간 사용에도 부작용이 전혀 없는 탈모 방지 및 모발 성장 촉진용 조성물을 제공하는 데 목적이 있다.It is an object of the present invention to provide a composition for preventing hair loss and promoting hair growth and having no side effects even when used for a long time, and for promoting hair growth, in particular, by activating hair follicle cells of the scalp, the hair growth promoting effect is excellent. And, it is an object to provide a composition for preventing hair loss and hair growth without any side effects even using for a long time using only components derived from natural materials.

이에 본 발명자는 천연물인 홍삼, 방풍, 형개, 고삼, 감초, 당귀, 김, 하수오, 승마, 소엽 및 황금으로부터 추출된 바이칼린을 최적의 비율로 함유하는 조성물을 개발함으로써, 두피 및 모발의 이상 증상에 대해 모두 우수한 개선 효과를 나타내며 장기간 사용에도 부작용을 유발하지 않는 탈모 방지 및 모발 성장 촉진용 조성물의 발명을 완성하였다.Accordingly, the present inventors developed a composition containing an optimal ratio of Baikal extracted from natural products such as red ginseng, windproof, hyungae, ginseng, licorice, donkey, seaweed, sewage, horse riding, leaflets and gold, thereby causing abnormal symptoms of the scalp and hair. Invented a composition for preventing hair loss and promoting hair growth, which shows excellent improvement effect for all and does not cause side effects even in long-term use.

본 발명은 탈모 방지 및 모발 성장 촉진용 조성물에 관한 것으로 보다 구체적으로는 홍삼, 병풍, 형개, 바이칼린, 고삼, 감초, 당귀, 김, 하수오, 승마 및 소엽(蘇葉)을 함유하는 것을 특징으로 한다.The present invention relates to a composition for preventing hair loss and promoting hair growth, and more specifically, red ginseng, folding screen, mold opening, Baikalin, red ginseng, licorice, donkey, seaweed, sewage, horse riding and leaflet (蘇葉), characterized in that do.

본 발명에 따른 유효성분에 함유되는 물질은 물, 유기용매 또는 이의 혼합용매에서 추출된 추출물인 것이 바람직하며, 홍삼 추출물 5 ~ 15 중량부, 방풍 추출물 4 ~ 5 중량부, 형개 추출물 2 ~ 5 중량부, 바이칼린 0.5 ~ 15 중량부, 고삼 추출물 1 ~ 5 중량부, 감초 추출물 0.1 ~5 중량부, 당귀 추출물 0.5 ~ 5중량부, 김 추출물 5 ~ 15 중량부, 하수오 추출물 0.5 ~ 5 중량부, 승마 추출물 10 ~ 20 중량부, 및 소엽 추출물 1 ~ 5 중량부로 이루어진 혼합물을 유효성분으로 함유하는 것이 바람직하며, 상기 유효성분의 함량에 제한을 둘 필요는 없으며, 제형 및 용도에 따라 조절할 수 있으나 전체 조성물의 0.1 ~ 15중량%인 것이 바람직하다. The substance contained in the active ingredient according to the present invention is preferably an extract extracted from water, an organic solvent or a mixed solvent thereof, 5 to 15 parts by weight of red ginseng extract, 4 to 5 parts by weight of windproof extract, 2 to 5 parts by weight of extract Part, Baikal 0.5 to 15 parts by weight, red ginseng extract 1 to 5 parts by weight, licorice extract 0.1 to 5 parts by weight, Angelica extract 0.5 to 5 parts by weight, seaweed extract 5 to 15 parts by weight, sewage extract 0.5 to 5 parts by weight, It is preferable to contain a mixture consisting of 10 to 20 parts by weight of the horse riding extract, and 1 to 5 parts by weight of the leaflet extract as an active ingredient, and there is no need to limit the content of the active ingredient, but it can be adjusted according to the formulation and the use, but the whole It is preferable that it is 0.1-15 weight% of a composition.

본 발명에 따른 조성물에 함유되는 바이칼린은 천연물질인 황금으로부터 추출된 것으로서 바람직하게는 황금을 에탄올 및 물의 혼합용매에 넣고 가열한 후 감압 농축하여 1차 추출물을 제조하는 단계, 상기 1차 추출물에 헥산을 첨가하여 불순물을 제거하는 단계, 불순물이 제거된 1차 추출물을 에틸아세테이트에 녹여 농축하는 단계, 및 재결정 단계를 통해서 제조된 것이다.Baikalin contained in the composition according to the present invention is extracted from the natural material of gold, preferably in a mixed solvent of ethanol and water, heated and concentrated under reduced pressure to prepare a primary extract, the primary extract It was prepared through the step of removing impurities by adding hexane, dissolving the primary extract from which impurities were removed in ethyl acetate, and recrystallization.

본 발명에 따른 조성물에 함유되는 홍삼, 방풍, 고삼, 하수오 및 소엽추출물 은 각각 물:에탄올 1:1.2~4 중량비의 혼합용매로부터 추출된 것이며, 형개는 헥산:에탄올 1:2~10 중량비의 혼합용매로부터 추출한 것이고, 당귀 및 승마 추출물은 열수 추출한 것이며, 감초추출물은 에틸아세테이트로 추출한 것이고, 김 추출물은 열수 추출한 후 감압농축하고, 물:에탄올 1:1.2~4 중량비의 혼합용매에서 재결정한 것이 바람직하다.The red ginseng, windproof, ginseng, sewage and lobular extracts contained in the composition according to the present invention are each extracted from a mixed solvent of water: ethanol 1: 1.2 to 4 weight ratio, and the mold is a mixture of hexane: ethanol 1: 2 to 10 weight ratio. Extracted from the solvent, Angelica extract and horse riding extract is hot water extraction, licorice extract is extracted with ethyl acetate, seaweed extract is concentrated under reduced pressure after hot water extraction, and recrystallized in a mixed solvent of water: ethanol 1: 1.2 ~ 4 weight ratio Do.

본 발명의 조성물은 모발의 탈모 방지효과, 발모효과, 양모효과가 우수하게 나타나며, 특히 모낭 세포의 활성화를 통해 탈모 방지 및 모발 성장 촉진 효과를 갖는 것을 특징으로 한다.The composition of the present invention is excellent in hair loss prevention effect, hair growth effect, wool effect, and in particular characterized in that it has a hair loss prevention and hair growth promoting effect through the activation of hair follicle cells.

또한, 본 발명에 따른 탈모 방지 및 모발 성장 촉진용 조성물은 유효성분으로 천연물에서 유래된 성분만을 함유하고 있어 유효성분이 화학물질인 경우에 비해 장기간 사용에 따른 부작용이 없는 장점을 가지고 있다.In addition, the composition for preventing hair loss and promoting hair growth according to the present invention contains only components derived from natural products as an active ingredient, and has an advantage that there are no side effects due to long-term use compared to the case where the active ingredient is a chemical.

이하 본 발명의 조성물이 함유하는 각 성분에 대해 상세히 설명한다.Hereinafter, each component contained in the composition of the present invention will be described in detail.

본 발명의 조성물이 함유하는 홍삼(Panax ginsengC.A Meyer)은 뿌리 부분에 배당체, 정유, 기름, 아미노산, 알카로이드, 탄수화물, 비타민, 수지, 미량원소 등을 함유한다. 홍삼의 배당체 성분 중에는 파나쿠일론, 파낙식, 파낙솔, 긴세닌 등의 배당체 혼합물 또는 파낙사디올-2-글루코시드 등이 함유되며, 파낙콘, 파낙신 등의 파낙사디올-3-글루코시드도 존재한다. 특히 본 발명에서 사용된 홍삼은 사포닌 중 진세노사이드(ginsenoside) Rg3, 진세노사이드(ginsenoside) Rg5, 진세노사이 드(ginsenoside) Rh2가 다량 함유되어 그 효과를 증대시키는데, 특히 진세노사이드(ginsenoside) Rg3는 혈관확장 및 혈류증대작용, 혈소판 응집억제작용, 뇌신경세포 보호작용, 스트레스 시 혈중 코르티코스테론(Corticosterone)의 증가 억제작용, 항암 및 면역기능 강화작용이 있으며, 진세노사이드(ginsenoside) Rg5는 혈소판 응집억제작용이 있는 것으로 보고되었다.Red ginseng (Panax ginseng C. A Meyer) contained in the composition of the present invention contains glycosides, essential oils, oils, amino acids, alkaloids, carbohydrates, vitamins, resins, trace elements and the like in the root portion. Glycoside components of red ginseng include glycoside mixtures such as panakuilon, panaksik, panaxol, ginsenin, or panaxadiol-2-glucoside, and the like, and panaxadiol-3-glucoside such as panaxone and panaxin. Also exists. In particular, the red ginseng used in the present invention is ginsenoside (ginsenoside) Rg 3 , Ginsenoside Rg 5 , It contains a large amount of ginsenoside Rh 2 , which enhances its effect. In particular, ginsenoside Rg 3 enhances vasodilation and blood flow, platelet aggregation, brain nerve cell protection, and blood corticosteroids during stress. It has been reported that there is an increase inhibitory effect of the cortosterone, anticancer and immune function enhancement, and ginsenoside Rg 5 has an inhibitory effect on platelet aggregation.

본 발명의 조성물이 함유하는 방풍(Saposhnikovia divaricata Schiskin)의 주요성분은 뿌리에 정유, 만니톨(mannitol), 고미배당체, 다당유 및 유기산 등이 함유되어 있고 과실에 함유된 정유성분중에는 α-피페닌(α-pinene), β-피페닌(β-pinene), 리모닌(limonene), 팔미트산(palmitic acid), 비사볼린(bisabolene) 등 약 66종의 화학 성분이 알려졌으며, 쿠마린(coumarin)류에는 임퍼라토린(imperatorin), 레데보릴롤(ledeboriellol)이 있으며 다당류에는 사포시코반(saposhikovan) A, B, C가 있다. 약리작용은 해열작용, 진통작용, 소염작용, 항경련작용, 평활근이완작용, 항균작용 등이 있다.The main components of the wind-resistant ( Saposhnikovia divaricata Schiskin ) contained in the composition of the present invention contains essential oils, mannitol, high glycosides, polysaccharide oils and organic acids in the root, and α-piphenin ( About 66 chemical components are known, including α-pinene, β-pipene, β-pinene, limonine, palmitic acid and bisabolene, and coumarins. There are imperatorin, ledeboriellol, and polysaccharides include saposhikovan A, B, and C. Pharmacological action is antipyretic, analgesic, anti-inflammatory, anticonvulsant, smooth muscle relaxation, antibacterial action.

본 발명의 조성물이 함유하는 형개(Schizonepeta tenuifolia)의 주요성분은 휘발성 오일(Volatile oils)을 함유하는데 오일 중에는 알파-메토닌(α-menthone)이 있다. 약리작용은 항균작용, 해열, 진통작용, 다종의 세균과 진균의 억제작용 등이 있다. Mold opening contained in the composition of the present invention ( Schizonepeta Tenuifolia ) contains the volatile oil (Volatile oils), among which alpha-methonine (α-menthone). Pharmacological action is antibacterial action, antipyretic, analgesic action, and inhibits a number of bacteria and fungi.

본 발명의 조성물이 함유하는 바이칼린은 황금으로부터 추출한 성분이다. 황금으로부터 분리해낸 바이칼린의 약리작용으로는 중추 억제 작용, 체온 조절 작용, 혈압 강하 작용, 모세혈관 강화 작용, 항동맥 경화 작용, 지방질 대사 개선 작용, 간장해 예방 작용, 이담작용, 항소화성 궤양 작용, 완졸작용, 진경작용, 기관 평활근에 대한 작용, 항염증 작용, 항알레르기 작용, 프로스 태그 런 진 생합성 저해 작용, 항종양 작용, 이뇨 작용, 신장에 대한 작용, 해독 작용, 항바이러스 작용, 피지선에 대한 작용, 항균 작용 등이 있다.Baikalin contained in the composition of the present invention is a component extracted from gold. The pharmacological action of Baikal isolated from gold is central inhibition, temperature control, blood pressure lowering, capillary strengthening, anti-arteriosclerosis, lipid metabolism improvement, hepatic injuries, dipharymia, anti-digestive ulcers , Anti-inflammatory effect, anti-inflammatory action, anti-allergic action, prostaglengin biosynthesis inhibitory action, anti-tumor action, diuretic action, kidney action, detoxification action, antiviral action, sebaceous gland Action, antibacterial action, and the like.

본 발명의 조성물이 함유하는 고삼(Sophora flavescens)은 주요성분으로 마트린(소포카르피딘), 옥시마트린, 소포라놀, 아나기린, 메틸시티진, 바브티플린, 소포카르핀, 알로마트린 이소안히드로이카리딘, 노르안히드로이카리딘, 글루코루테올린, 전초에서 켐페롤-3-소포로시드, 헤니스테인등이 있고 약리작용으로는 항알레르기, 이뇨작용, 항균작용, 자궁수축작용 등이 있다.The ginseng ( Sophora flavescens ) contained in the composition of the present invention is the main ingredient is matrin (sofocarpidine), oxymatrine, sophoranol, anagirin, methylcytizin, babifflin, sopocarpine, allomatrine isohydro Icarridine, noranhydroicaridine, glucoluteolin, camphorol-3-sorboside, henistein, etc. in the outpost, pharmacological action is anti-allergic, diuretic, antibacterial, uterine contraction.

본 발명의 조성물이 함유하는 감초(Glycyrrhiza uralensis)는 주요성분으로 플라보노이드, 트리펜계 사포닌, 사포나레틴, 리쿠라시드, 글라브리딘 등이 있고, 약리작용으로는 해독작용, 식중독, 황달, 간경변증, 만성간질환, 류마치스, 항염증 작용, 진경작용, 항궤양, 항암활성작용 등이 있다.Licorice ( Glycyrrhiza uralensis ) contained in the composition of the present invention as a main component, flavonoids, tripene-based saponins, saponaretin, licuraside, glabridine, etc., pharmacological action detoxification, food poisoning, jaundice, cirrhosis, chronic Liver disease, rheumatism, anti-inflammatory action, myrrhosis, anti-ulcer, anti-cancer activity and so on.

본 발명의 조성물이 함유하는 당귀(Angelica gigas Nakai)는 성분은 베르갑텐, 이소핌피넬린, 니코틴산, 비타민B12, n-부틸리덴프탈리트, 리구스틸리트, 데쿠르신, 데쿠르시놀, 쿠마린, 노다케네린, 움벨리페론, 노다케닌, 크산토톡신, 이소핌피넬린, 오스톨, 움벨리프레닌 등이 있고, 약리작용으로는 혈압내림작용, 이뇨작용, 진정작용, 단백질 합성, 세포조직의 신생, 신진대사를 활성, 진통과 소염작용등이 있다. Angelica gigas Nakai contained in the composition of the present invention is the component is bergaptene, isoprimpinellin, nicotinic acid, vitamin B12, n-butylidenephthalate, ligustilite, decursin, decursinol, coumarin, noda Kenerine, Umbeliferon, Nodakenin, Xanthotoxin, Isomepipinelin, Ostol, Umbelifrinin, etc. Pharmacological actions include blood pressure lowering, diuresis, sedation, protein synthesis, and cell tissue , Metabolism active, analgesic and anti-inflammatory action.

본 발명의 조성물이 함유하는 김은 주요성분으로 한천, 헤미셀룰로오스, 소르비톨, 트레오닌, 발린, 로이신, 이소로이신, 리신, 메티오닌, 페닐알라닌, 트립토판, 나트륨, 칼륨, 칼슘, 인, 철, 카로틴, 비타민 A, 리보플라빈, 니아신, 비타민 C, 푸코에리트로빈, 디메틸술파이드, 글리신, 알라닌 등이 있고, 약리작용으로는 진정작용, 단백질 합성, 세포활성, 신진대사 활성작용 등이 있다.The laver contained in the composition of the present invention contains agar, hemicellulose, sorbitol, threonine, valine, leucine, isoleucine, lysine, methionine, phenylalanine, tryptophan, sodium, potassium, calcium, phosphorus, iron, carotene, vitamin A, Riboflavin, niacin, vitamin C, fucoerythrobin, dimethylsulfide, glycine, alanine and the like, pharmacological action, sedation, protein synthesis, cell activity, metabolic activity and the like.

본 발명의 조성물이 함유하는 하수오는 주요성분으로 레시틴, 당 조지방, 광물질, 시난코톡신, 폴리옥시프레그난에스테르, 찌빌리코시드 D 등이 있고, 약리작용으로는 모발을 검게 하고, 통증완화, 항염, 세포재생 등이 있다.The sewage contained in the composition of the present invention includes lecithin, crude crude fat, minerals, cinnacotoxin, polyoxypregnan ester, civicicoside D, etc., and the pharmacological action makes the hair black, pain relief, Anti-inflammatory, cell regeneration.

본 발명의 조성물이 함유하는 승마는 성분으로는 β-시토스테롤(β-sitosterol), 시미시푸고사이드(cimicifugoside), 페룰린산(ferulic acid), 시미게놀(cimigenol), 메틸시미시푸고사이드(methylcimicifugoside), 시클로아탄(cycloartane)형 트리터핀(triterpene) 등이 있고 약리작용으로는 해열, 종독, 창저, 해독, 소아뇨혈, 편두염 편도염, 세포재생 신진대사 활성작용 등이 있다.Riding in the composition of the present invention as a component β-sitosterol (β-sitosterol), cimicifugoside (cimicifugoside), ferulic acid (ferulic acid), cimigenol (cimigenol), methylcimicifugoside (methylcimicifugoside) And cycloatan (cycloartane) triterpene (triterpene) and the like pharmacological action is antipyretic, detoxification, intestinal, detoxification, pediatric urine, migraine tonsillitis, cell renewal metabolic activity.

본 발명의 조성물이 함유하는 소엽(蘇葉, 학명:Perilla frutescens var. acuta kudo)은 주요성분으로 엘-페릴라알데히드 엘-리모넨, 알파-피넨, 디히드로쿠민, 시아닌클로리드, 파라쿠마르산에스테르,비타민B1리놀산, 리놀레인산등이 있고, 약리작용으로는 발한제, 진정효과, 이뇨효과등이 있다.The leaflets contained in the composition of the present invention (Perilla frutescens var. Acuta kudo) is the main component of L-perillaaldehyde L-limonene, alpha-pinene, dihydrocumin, cyanine chloride, parakumaric acid ester , Vitamin B1 linoleic acid, linoleic acid and the like, pharmacological action is an antiperspirant, sedative effect, diuretic effect.

이하 본 발명의 조성물의 제조방법에 대해 설명한다.Hereinafter, a method for preparing the composition of the present invention will be described.

본 발명의 조성물에 함유되는 홍삼, 병풍, 형개, 고삼, 감초, 당귀, 김, 하 수오, 승마 및 소엽은 각 시료를 건조한 후 열수 추출 또는 유기용매 추출하여 제조하는 것이 바람직하다.The red ginseng, folding screen, mold opening, ginseng, licorice, donkey, seaweed, sewage, horseback riding and leaflet contained in the composition of the present invention is preferably prepared by drying each sample and then extracting hot water or organic solvent.

본 발명에 따른 조성물에 함유되는 홍삼, 방풍, 고삼, 하수오 및 소엽추출물은 각각 물:에탄올 1:1.2~4 중량비의 혼합용매로부터 추출된 것이며, 형개는 헥산:에탄올 1:2~10 중량비의 혼합용매로부터 추출한 것이고, 당귀 및 승마 추출물은 열수 추출한 것이며, 감초추출물은 에틸아세테이트로 추출한 것이고, 김 추출물은 열수 추출한 후 감압농축하고, 물:에탄올 1:1.2~4 중량비의 혼합용매에서 재결정한 것이 바람직하다. The red ginseng, windproof, ginseng, sewage and lobular extracts contained in the composition according to the present invention are each extracted from a mixed solvent of water: ethanol 1: 1.2 to 4 weight ratio, and the mold is a mixture of hexane: ethanol 1: 2 to 10 weight ratio. Extracted from the solvent, Angelica extract and horse riding extract is hot water extraction, licorice extract is extracted with ethyl acetate, seaweed extract is concentrated under reduced pressure after hot water extraction, and recrystallized in a mixed solvent of water: ethanol 1: 1.2 ~ 4 weight ratio Do.

본 발명에 따른 조성물에 함유되는 바이칼린은 천연물질인 황금으로부터 추출된 것으로서 바람직하게는 황금을 에탄올 및 물의 혼합용매에 넣고 가열한 후 감압 농축하여 1차 추출물을 제조하는 단계, 상기 1차 추출물에 헥산을 첨가하여 불순물을 제거하는 단계, 불순물이 제거된 1차 추출물을 에틸아세테이트에 녹여 농축하는 단계, 및 재결정 단계를 통해서 제조된 것이다.Baikalin contained in the composition according to the present invention is extracted from the natural material of gold, preferably in a mixed solvent of ethanol and water, heated and concentrated under reduced pressure to prepare a primary extract, the primary extract It was prepared through the step of removing impurities by adding hexane, dissolving the primary extract from which impurities were removed in ethyl acetate, and recrystallization.

상기 승마추출물 및 바이칼린 제조시 물 또는 물과 에탄올 혼합용매에 셀룰라아제 등의 당분해 효소를 첨가하고 가열 온도는 40 내지 60℃로 유지하는 것이 것이 보다 바람직하다.It is more preferred that glycolytic enzymes such as cellulase are added to water or a mixed solvent of water and ethanol during the preparation of the equestrian extract and bicalin and the heating temperature is maintained at 40 to 60 ° C.

상기와 같이 각 성분의 추출물을 얻은 후 홍삼 5 ~ 15 중량부, 방풍 4 ~ 5 중량부, 형개 2 ~ 5 중량부, 바이칼린 0.5 ~ 15 중량부, 고삼 1 ~ 5 중량부, 감초 0.1 ~5 중량부, 당귀 0.5 ~ 5중량부, 김 5 ~ 15 중량부, 하수오 0.5 ~ 5 중량부, 승마 10 ~ 20 중량부, 및 소엽 1 ~ 5 중량부로 혼합한 혼합물을 제조하는 것이 바 람직하며, 상기 혼합비로 제조되는 경우에 최적의 효과를 나타내게 된다. 상기 혼합물을 유효성분으로 함유하는 탈모 방지 및 모발 성장 촉진용 조성물 제조시 상기 유효성분 혼합물의 함량에 제한을 둘 필요는 없으나 전체 조성물의 0.1 ~ 15중량%인 것이 바람직하다.After obtaining the extract of each component as described above, red ginseng 5 ~ 15 parts by weight, windproof 4 ~ 5 parts by weight, mold opening 2 ~ 5 parts by weight, Baikalin 0.5 ~ 15 parts by weight, red ginseng 1 ~ 5 parts by weight, licorice 0.1 ~ 5 It is preferable to prepare a mixture mixed by weight parts, Angelica 0.5 to 5 parts by weight, laver 5 to 15 parts by weight, sewage 0.5 to 5 parts by weight, horse riding 10 to 20 parts by weight, and leaflets 1 to 5 parts by weight. In the case of the mixing ratio, the optimum effect is obtained. When preparing a composition for preventing hair loss and promoting hair growth containing the mixture as an active ingredient, it is not necessary to limit the content of the active ingredient mixture, but preferably 0.1 to 15% by weight of the total composition.

본 발명에 따른 탈모 방지 및 모발 성장 촉진용 화장품 조성물 또는 약제학적 조성물에서 추가로 함유될 수 있는 성분들은 두피 및 모발의 국부적 표면에 직접 적용되어 두피 및 모발의 개선 효과를 증진시킬 수 있는 성분이면 모두 사용가능하며, 구체적으로는 티로시나제 활성촉진제, 침투촉진제, 혈류촉진제, 모포부활제 또는 5-리덕타제 억제제, 두피영양제, 가려움 억제제 등이 있다.Ingredients which may be further contained in the cosmetic composition or pharmaceutical composition for preventing hair loss and promoting hair growth according to the present invention may be applied directly to the scalp and the local surface of the hair so as to enhance the scalp and hair improvement effects. It may be used, and specifically, there are tyrosinase activators, penetration promoters, blood flow promoters, follicle inactivators or 5-reductase inhibitors, scalp nutrients, itching inhibitors and the like.

티로시나제 활성 촉진제는 구체적으로 상백피 추출물, 녹차 추출물 등이 될 수 있다. 침투촉진제 및 혈류촉진제는 구체적으로 창포 추출물, 당귀 추출물, 위치하젤 추출물, 연명초 추출물, 천궁 추출물, 카모마일 추출물 등이 될 수 있다. 모포부활제는 구체적으로 정향 추출물, 지황 추출물, 산초 추출물 등이 될 수 있다. 5 -리덕타제 억제제는 구체적으로 회향 추출물, 금잔화 추출물, 알로에 추출물, 천궁 추출물, 지황 추출물 등이 될 수 있다. 두피영양제는 구체적으로 철분, 칼슘, 망간, 필수 아미노산, 염산 피리독신, 비오틴, 비타민 B1, 비타민 B2, 비타민 B6, 비타민 D 및 엽산으로 이루어진 1가지 이상되는 비타민 또는 비타민 전구체, 멘톨 디엘-판테놀, 폴리쿼터늄-7, 트리세틸모늄클로라이드, 디메치콘/이소라우레스-6, 세틸트리메칠암모늄클로라이드, 세테아릴알코올, 케라틴, 아미노산, 사이클로펜타실록산/디메치콘, 디메치콘/이소라우레스-6 이외 각종 미네랄 등이 될 수 있다. 가 려움 억제제는 구체적으로 컴푸리 추출물, 범부채 추출물, 페파민트 및 이들의 혼합물 등이 될 수 있다.In particular, the tyrosinase activity promoter may be an extract of green tea, green tea extract, or the like. Penetration accelerator and blood flow promoting agent may be specifically iris extract, Angelica extract, witch hazel extract, Myeongmyeoncho extract, Cheongung extract, chamomile extract and the like. The blanket deactivator may be specifically clove extract, turmeric extract, sancho extract, and the like. The 5-reductase inhibitor may specifically be a fennel extract, a marigold extract, an aloe extract, a celery extract, a turmeric extract, or the like. Scalp nutrients specifically include one or more vitamins or vitamin precursors consisting of iron, calcium, manganese, essential amino acids, pyridoxine hydrochloride, biotin, vitamin B1, vitamin B2, vitamin B6, vitamin D and folic acid, menthol die-panthenol, polyquater Other than nium-7, tricetylmonium chloride, dimethicone / isolaures-6, cetyltrimethylammonium chloride, cetearyl alcohol, keratin, amino acid, cyclopentasiloxane / dimethicone, dimethicone / isolaures-6 And various minerals. The itch inhibitor may specifically be a compressor extract, panchae extract, peppermint and mixtures thereof.

본 발명의 탈모방지 및 모발 성장 촉진용 화장품 조성물은 일반적인 두피 및 모발용 외용제제에 배합될 수 있는 기제 성분을 필요에 따라 추가할 수 있다. 구체적으로는 용해보조제, 계면활성제, 보습제, 점증제, pH 조정제, 방부제, 산화방지제, 금속이온봉쇄제, 살균제, 항염증제, 항미생물제, 용제, 착색제, 또는 착향제 등이 있다. 용해보조제는 구체적으로 이소프로필 미리스테이트, 폴리에틸렌 글리콜, 중쇄 지방산 트리글리세리드, 탄화수소, 글리콜류 등이 될 수 있다. The cosmetic composition for preventing hair loss and promoting hair growth of the present invention may add a base component that can be blended with general scalp and hair external preparations as needed. Specific examples include dissolution aids, surfactants, moisturizers, thickeners, pH adjusters, preservatives, antioxidants, metal ion sequestrants, fungicides, anti-inflammatory agents, antimicrobial agents, solvents, colorants, or flavoring agents. Dissolution aids may specifically be isopropyl myristate, polyethylene glycol, medium chain fatty acid triglycerides, hydrocarbons, glycols, and the like.

계면활성제 중 음이온계 계면활성제는 구체적으로 암모늄 라우릴술포숙시네이트, 암모늄 라우릴 설페이트, 소디움 코코일이세시오네이트, 소디움 라우릴 이세시오네이트, 소디움 라우릴 설페이트, 트리에탄올아민 라우릴 설페이트, 소디움 라우릴 에테르 설페이트(에틸렌옥사이드 1∼3개) 등이 될 수 있다. 계면활성제 중 비이온성 계면활성제는 구체적으로 폴리옥시에틸렌알킬에테르, 폴리옥시에틸렌지방산 에스테르, 폴리옥시에틸렌, 경화 피마자유 유도체, 지방산 디에탄올아미드, 글리세릴스테아레이트 등이 될 수 있다. 계면활성제 중 양이온성 계면활성제는 구체적으로 3급 지방족 아민염, 알킬트리메칠암모늄클로라이드, 디알킬디메칠암모늄클로라이드 등이 될 수 있다. 계면활성제 중 양쪽성 계면활성제는 구체적으로 베타인, 아미드베타인형, 설포베타인형, 스테아르트리모늄클로라이드 등이 될 수 있다.Among the surfactants, anionic surfactants are specifically ammonium lauryl sulfosuccinate, ammonium lauryl sulfate, sodium cocoyl isionate, sodium lauryl isceionate, sodium lauryl sulfate, triethanolamine lauryl sulfate, sodium Lauryl ether sulfate (1 to 3 ethylene oxides) and the like. Among the surfactants, nonionic surfactants may specifically be polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene, cured castor oil derivatives, fatty acid diethanolamides, glyceryl stearate, and the like. The cationic surfactant in the surfactant may specifically be a tertiary aliphatic amine salt, alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, or the like. Among the surfactants, the amphoteric surfactant may specifically be betaine, amidebetaine type, sulfobetaine type, steartrimonium chloride, or the like.

보습제는 구체적으로 글리세린, 프로필렌글리콜, 1,3-부틸렌글리콜, 디프로필렌글리콜, 소르비톨 등이 될 수 있다. Moisturizing agent may be specifically glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, sorbitol and the like.

점증제는 구체적으로 메틸셀룰로스, 하이드록시에틸셀룰로스, 카라기난, 카르복시메틸셀룰로스, 하이드록시메틸셀룰로스 등의 수용성 고분자 화합물이 될 수 있다.The thickener may specifically be a water-soluble high molecular compound such as methyl cellulose, hydroxyethyl cellulose, carrageenan, carboxymethyl cellulose, hydroxymethyl cellulose and the like.

pH 조정제는 구체적으로 구연산, 수산화나트륨, 트리에탄올아민, 구연산나트륨, 인산, 인산나트륨, 젖산 등이 될 수 있다.The pH adjusting agent may specifically be citric acid, sodium hydroxide, triethanolamine, sodium citrate, phosphoric acid, sodium phosphate, lactic acid and the like.

방부제는 구체적으로 벤조산, 파라옥시안식향산에스테르, 메칠클로로이소치아졸리논의 혼합물, 페녹시에탄올, 디엠디엠히단토인 등이 될 수 있다.Preservatives may specifically be benzoic acid, paraoxybenzoic acid esters, mixtures of methylchloroisothiazolinone, phenoxyethanol, DMDM hydantoin and the like.

산화방지제는 구체적으로 디부틸히드록시톨루엔, 아스코르빈산 등이 될 수 있다.Antioxidants may specifically be dibutylhydroxytoluene, ascorbic acid and the like.

금속이온봉쇄제는 구체적으로 에틸렌디아민테트라초산디나트륨, 에틸렌디아민테트라초산테트라나트륨 등이 될 수 있다.Specifically, the metal ion blocking agent may be ethylenediaminetetraacetate acetate, ethylenediaminetetraacetate tetrasodium, or the like.

살균제는 구체적으로 클로르헥시딘 글루코네이트, 4급 암모늄염, 피록톤올아민, 아연피리치온 현탁액, 요도프로피닐 부틸카바메이트, 살리실산 등이 될 수 있다.Fungicides may specifically be chlorhexidine gluconate, quaternary ammonium salts, pyroxtonolamines, zinc pyrithione suspensions, iodopropynyl butylcarbamate, salicylic acid and the like.

항염증성분은 구체적으로 글리시리진산모노암모늄, 글리시리진산디칼륨, 스테아릴글리시리지네이트, 카모마일, 알파 비사보롤, 알란토인 및 이들의 혼합물 등이 될 수 있다.The anti-inflammatory component may specifically be monoammonium glycyrrhinate, dipotassium glycyrizine, stearyl glycyrizinate, chamomile, alpha bisabolol, allantoin and mixtures thereof.

항미생물성분은 구체적으로 페녹시에탄올, 클로르헥시딘, 클로르헥시딘 글루코네이트, 피록톤올아민, 케토코나졸, 아르니카추출물, 요도프로피닐부틸카바메이트, 벤잘코늄클로라이드, 벤젠토늄클로라이드, 벤조산 및 그의 염, 벤질알코올, 라 벤다, 로즈마리, 살리실산, 트리클로카르반, 아연피리치온 현탁액 및 그들의 혼합물 등이 될 수 있다.The antimicrobial component is specifically phenoxyethanol, chlorhexidine, chlorhexidine gluconate, pyroxtonolamine, ketoconazole, arnica extract, iodopropynylbutylcarbamate, benzalkonium chloride, benzenetonium chloride, benzoic acid and salts thereof, benzyl alcohol, lavenda , Rosemary, salicylic acid, triclocarban, zinc pyrithione suspensions and mixtures thereof and the like.

용제는 구체적으로 에탄올, 정제수, 트윈 20, 사이클로메치콘, 미네랄오일, 디메치콘 등이 될 수 있다.The solvent may be specifically ethanol, purified water, Tween 20, cyclomethicone, mineral oil, dimethicone, and the like.

착색제와 착향제는 일반적인 두피 및 모발용 제제에 사용되는 기제들을 사용할 수 있다.Colorants and flavoring agents can use the bases used in general scalp and hair preparations.

본 발명의 탈모 방지 및 모발 성장 촉진용 화장품 조성물은 통상적으로 두피 및 모발에 적용시킬 수 있는 모든 제형으로 제조될 수 있으며, 그 예로 삼푸, 헤어트리트먼트, 헤어토닉, 헤어팩, 삼푸와 린스의 혼합형 등을 들 수 있다. 본 발명의 탈모 방지 및 모발 성장 촉진용 화장품 조성물은 두피나 모발에 직접 도포하거나 살포하는 등의 경피 투여 방법으로 사용하는 것이 바람직하다.Hair loss prevention and hair growth promoting cosmetic composition of the present invention can be prepared in general in any formulation that can be applied to the scalp and hair, for example, shampoo, hair treatment, hair tonic, hair pack, mixed type of shampoo and rinse Can be mentioned. It is preferable to use the cosmetic composition for preventing hair loss and promoting hair growth of the present invention by a transdermal administration method such as directly applying or spraying to the scalp or hair.

한편 본 발명의 탈모 방지 및 모발 성장 촉진용 약제학적 조성물은 약제학적으로 적합하며 생리학적으로 허용되는 보조제를 추가로 함유하여 제조될 수 있으며, 상기 보조제로는 용매, 붕해제, 감미제, 결합제, 피복제, 팽창제, 윤활제, 활택제 또는 향미제 등의 가용화제를 사용할 수 있다.Meanwhile, the pharmaceutical composition for preventing hair loss and promoting hair growth of the present invention may be prepared by further containing a pharmaceutically acceptable and physiologically acceptable adjuvant, and the adjuvant may include a solvent, a disintegrant, a sweetener, a binder, blood Solubilizers such as replication, swelling agents, lubricants, lubricants or flavoring agents can be used.

본 발명의 탈모 방지 및 모발 성장 촉진용 약제학적 조성물은 투여를 위해 상기 기재한 유효성분 이외에, 약제학적으로 허용 가능한 담체를 1종 이상 추가로 포함하여 제제화할 수 있다.The pharmaceutical composition for preventing hair loss and promoting hair growth of the present invention may be formulated to include at least one pharmaceutically acceptable carrier, in addition to the active ingredient described above for administration.

약제학적으로 허용 가능한 담체는 식염수, 멸균수, 링거액, 완충 식염수, 덱스트로즈 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 하나 이상 을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다.Pharmaceutically acceptable carriers may be used in combination with saline, sterile water, Ringer's solution, buffered saline, dextrose solution, maltodextrin solution, glycerol, ethanol and one or more of these components, as necessary, including antioxidants, buffers, Other conventional additives such as bacteriostatic agents can be added.

또한 본 발명의 탈모 방지 및 모발 성장 촉진용 약제학적 조성물은 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다. In addition, the pharmaceutical composition for preventing hair loss and promoting hair growth according to the present invention may be added to a diluent, a dispersant, a surfactant, a binder, and a lubricant by adding an injectable formulation such as an aqueous solution, a suspension, an emulsion, a pill, a capsule, a granule, or a tablet. It can be formulated as.

본 발명의 탈모 방지 및 모발 성장 촉진용 약제학적 조성물은 목적하는 방법에 따라 정맥내, 동맥내, 복강내, 근육내, 동맥내, 복강내, 흉골내, 경피, 비측내, 흡입, 국소, 직장, 경구, 안구내 또는 피내 경로를 통해 통상적인 방식으로 투여할 수 있다.The pharmaceutical composition for preventing hair loss and promoting hair growth of the present invention may be intravenous, intraarterial, intraperitoneal, intramuscular, intraarterial, intraperitoneal, sternum, transdermal, nasal, inhalation, topical or rectal. Administration can be in conventional manner via the oral, intraocular or intradermal route.

본 발명의 조성물의 사용량은 연령, 병변의 정도 등의 개인 차이나 제형, 형태에 따라 적절하게 조절될 수 있으며, 일일 200∼1000mg 정도의 범위 내에서 사용하는 것이 바람직하다. 본 발명의 조성물이 함유하는 성분들은 오랫동안 임상에 적용되어 인체 안정성이 입증되어 있는 성분들이며, 장기간에 걸쳐 사용하여도 부작용을 유발하지 않는다. 본 발명의 조성물은 두피 및 모발 상태의 개선을 위한 화장품, 의약품, 또는 의약외품으로 유용하게 사용될 수 있다.The amount of the composition of the present invention can be appropriately adjusted according to the individual differences, the dosage form, the form of age, the extent of the lesion, etc., preferably used in the range of about 200 to 1000 mg per day. The components contained in the composition of the present invention are components that have been clinically applied for a long time and demonstrated human stability, and do not cause side effects even when used for a long time. The composition of the present invention can be usefully used as a cosmetic, pharmaceutical, or quasi-drug for improving the scalp and hair condition.

이하, 본 발명의 이해를 돕기 위하여 바람직한 실시예를 제시한다. 그러나 하기의 실시예는 본 발명을 보다 쉽게 이해하기 위하여 제공되는 것일 뿐, 실시예에 의해 본 발명의 내용이 한정되는 것은 아니다.Hereinafter, preferred examples are provided to aid in understanding the present invention. However, the following examples are merely provided to more easily understand the present invention, and the contents of the present invention are not limited by the examples.

제조예 1. 홍삼추출물 제조Preparation Example 1. Preparation of Red Ginseng Extract

홍삼은 양질의 원료를 선별하여 추출탱크에 투입한 후, 80중량% 에탄올 수용액을 사용하여 3회 가압 가온 추출한다. 추출한 후 여과지를 사용하여 여과한 후 감압농축하여, 홍삼 추출물을 얻는다.Red ginseng is selected from high-quality raw materials and added to the extraction tank, and extracted by pressurized heating three times using 80% by weight ethanol aqueous solution. After extraction, the resultant was filtered using filter paper and concentrated under reduced pressure to obtain a red ginseng extract.

제조예 2. 방풍, 고삼, 하수오, 소엽추출물 제조Preparation Example 2. Windproof, Gosam, Sewage, Leaflet Extract

방풍, 고삼추, 하수오, 소엽은 각각 70중량% 에탄올 수용액을 첨가하고 실온 상태에서 3일간 방치한 후 여과하고, 감압농축하여, 방풍, 고삼추, 하수오, 소엽추출물을 각각 제조한다.Windproof, red ginseng, sewage, leaflets are each added 70% by weight of ethanol aqueous solution, left for 3 days at room temperature, filtered, and concentrated under reduced pressure to prepare a windbreak, gosamchu, sewage, leaflet extract, respectively.

제조예 3. 형개추출물 제조Preparation Example 3 Preparation of Mold Open Extract

형개는 에탄올 90중량% 및 헥산 10중량%를 혼합한 용매에 첨가하여 실온 상태에서 3일간 방치 한 후 여과하고, 감압농축하여, 형개추출물을 얻는다. The mold opening is added to a solvent in which 90% by weight of ethanol and 10% by weight of hexane are added, and the mixture is left to stand at room temperature for 3 days, filtered, and concentrated under reduced pressure to obtain a mold opening extract.

제조예 4. 황금추출물로부터 바이칼린 제조Preparation Example 4 Preparation of Baikal from Golden Extract

황금을 에탄올 함량 70중량%인 수용액에 1중량%가 되도록 셀룰라아제를 첨가하여 24시간 60도에서 유지한 후 여과하고, 감압농축하여, 황금추출물을 얻는 후 핵산에 용출하여 불순물을 제거하고 에틸아세테이트에 용출한 액을 농축한 후 적당량의 에탄올과 물의 혼합물에 재결정하여 고순도의 바이칼린을 얻는다.Cellulase was added to an aqueous solution containing 70% by weight of ethanol to 1% by weight, maintained at 60 ° C for 24 hours, filtered, concentrated under reduced pressure, eluted with a nucleic acid, eluted with nucleic acid to remove impurities, and then added to ethyl acetate. The eluted solution is concentrated and then recrystallized in a mixture of ethanol and water to obtain high-purity bicalin.

제조된 바이칼린의 구조 및 1H-NMR 스펙드럼을 도 1에 도시하였으며, 도 2에 바이칼린의 HPLC 결과를 나타내었다. 도2의 (a)는 알려진 순수한 바이칼린의 HPLC 결과이고, (b)는 본 제조예에서 제조한 바이칼린의 HPLC 결과이다. 상기 1H-NMR 및 HPLC 결과로부터 92.5% 순도의 바이칼린이 얻어진 것을 확인하였다.The structure and 1 H-NMR spectra of the prepared baikalin is shown in Figure 1, the HPLC results of the Baikallin is shown in FIG. Figure 2 (a) is the HPLC results of known pure Baikal, (b) is the HPLC results of Baikal prepared in this Preparation Example. It was confirmed from the 1 H-NMR and HPLC results that 92.5% purity of bicalin was obtained.

제조예 5. 감초추출물 제조Preparation Example 5 Licorice Extract Preparation

감초는 에틸아세테이트를 첨가하여 실온 상태에서 3일간 방치 한 후 여과하고, 감압농축하여, 감초추출물을 얻는다. Licorice was added to ethyl acetate, left at room temperature for 3 days, filtered and concentrated under reduced pressure to obtain a licorice extract.

제조예 6. 당귀추출물 제조Preparation Example 6 Preparation of Angelica Extract

당귀는 80℃로 열수 추출한 후 여과하고, 감압농축하여 수분을 제거하여, 당귀추출물을 얻는다. Angelica is extracted with hot water at 80 ° C., filtered, concentrated under reduced pressure to remove moisture, and Angelica extract is obtained.

제조예 7. 김추출물 제조Preparation Example 7 Preparation of Seaweed Extract

김은 80℃로 열수 추출한 후 여과하고, 감압농축하여 수분을 제거하고 95% 주정에 침지한 후 결정체 만을 회수하여 김추출물을 얻는다. The seaweed is extracted with hot water at 80 ° C., filtered, concentrated under reduced pressure to remove water, immersed in 95% alcohol, and only the crystals are recovered to obtain a seaweed extract.

제조예 8. 승마추출물 제조Preparation Example 8 Preparation of Horse Riding Extract

승마는 정제수에 셀룰라아제를 1중량%가 되도록 첨가한 후 50℃로 열수 추출 한 후 여과하고, 감압농축하여 수분을 제거하고 주정에 침지한 후 결정체만을 회수하여 승마추출물을 얻는다.Horse riding is added to 1% by weight of cellulase to purified water and then extracted with hot water at 50 ℃ filtered, concentrated under reduced pressure to remove the water and immersed in alcohol and recover only the crystals to obtain a horse riding extract.

제조예 9. 본 발명에 따른 유효성분 혼합물의 제조Preparation Example 9 Preparation of an Active Ingredient Mixture According to the Present Invention

제조예 1 내지 8 에서 제조된 각 성분의 추출물을 홍삼 10 중량부, 방풍 5 중량부, 형개 3 중량부, 바이칼린 8 중량부, 고삼 3중량부, 감초 3 중량부, 당귀 3 중량부, 김 8중량부, 하수오 3 중량부, 승마 15중량부, 소엽 3중량부로 혼합한 추출물 혼합물(JH-IJ AC 추출물)을 제조하였다.Extract of each component prepared in Preparation Examples 1 to 8 red ginseng 10 parts by weight, windproof 5 parts by weight, mold opening 3 parts by weight, Baikalin 8 parts by weight, red ginseng 3 parts by weight, licorice 3 parts by weight, Angelica 3 parts by weight, seaweed An extract mixture (JH-IJ AC extract) was prepared by mixing 8 parts by weight, 3 parts by weight of sewage, 15 parts by weight of horse riding, and 3 parts by weight of leaflets.

실시예 1. 탈모 방지 및 모발 성장 촉진용 샴푸의 제조Example 1. Preparation of a shampoo for preventing hair loss and promoting hair growth

하기 표 1과 같이 원료를 혼합하여 탈모방지 및 모발 성장 촉진용 삼푸 조성물을 제조하였다.By mixing the raw materials as shown in Table 1 to prepare a shampoo composition for hair loss prevention and hair growth.

하기 표 1의 원료 No.1∼13를 메인 작업조에 투입하고 80℃가온 교반 용해 후 45도로 냉각한다. 원료 No.14∼18과 원료 No.19를 투입하여 교반한다.Raw materials Nos. 1 to 13 shown in Table 1 below were added to the main working tank, and cooled to 45 degrees after 80 ° C stirring and melting. Raw materials No. 14-18 and raw material No. 19 are added and stirred.

[표 1]TABLE 1

Figure 112007005025430-pat00001
Figure 112007005025430-pat00001

실시예 2 및 3. 탈모 방지 및 모발 성장 촉진용 팩의 제조Examples 2 and 3. Preparation of a pack for preventing hair loss and promoting hair growth

하기 표 2의 실험의 시료로 사용한 탈모 및 모발개선제의 제조는 각각의 원료 No.1∼5와 원료 No.6∼19를 각각의 부작업조에 투입하고 80℃ 가온로 교반 용해 후 주 작업조로 이송하여 균일하게 혼합되도록 교반 후 50℃로 냉각한다. 원료 No. 20~21 및 22를 투입하여 균일하게 혼합되도록 교반한다. In the preparation of the hair loss and the hair improver used as the samples of the experiment shown in Table 2, each of the raw materials No. 1 to 5 and the raw materials No. 6 to 19 were put into each sub-working tank, stirred and dissolved in an 80 ° C. heating furnace, and then transferred to the main working tank. After stirring to cool uniformly to 50 ℃. Raw material No. Add 20 ~ 21 and 22 and stir to mix uniformly.

[표 2]TABLE 2

Figure 112007005025430-pat00002
Figure 112007005025430-pat00002

실험예 1. 급성 독성 실험Experimental Example 1. Acute toxicity test

25±5g의 ICR계 마우스(대한실험동물)와 235±10g의 특정병원부재(SPF) 스프 라그-도올리(Sprague Dawley, Biogenomics사) 래트를 각각 3마리씩 36군으로 나누어 본 발명의 제조예에서 제조된 각각의 홍삼, 방풍, 형개, 고삼, 감초, 당귀, 김, 하수오, 승마 및 소엽추출물, 바이칼린, 및 이의 혼합물을 각각 20mg/㎏, 10mg/㎏, 1mg/㎏의 용량으로 복강투여한 후 24시간 동안 독성여부를 관찰하였다.In the preparation of the present invention, 25 ± 5g of ICR mice (Korean experimental animals) and 235 ± 10g of SPF sprag-dooli (Sprague Dawley, Biogenomics) rats were divided into 36 groups of 3 mice each. Each of the prepared red ginseng, windproof, hyunggae, ginseng, licorice, donkey, seaweed, sewage, horse riding and lobular extract, Baikal, and mixtures thereof were intraperitoneally administered at doses of 20 mg / kg, 10 mg / kg, and 1 mg / kg, respectively. The toxicity was observed for 24 hours.

실험 결과, 36군 모두에서 사망한 예를 전혀 관찰할 수 없었고, 체중 증가, 사료 섭취량 등에서 외견상 대조군과 별다른 증상을 찾아볼 수 없었다. 따라서 본 발명의 추출물이 안전한 약물임을 확인할 수 있었다.As a result, no deaths were observed in all 36 groups, and no significant symptoms were found in weight gain and feed intake. Therefore, it was confirmed that the extract of the present invention is a safe drug.

실험예Experimental Example 2. 발모실험 I 2. Hair Growth Experiment I

생 후 5주령의 마우스(C57BL,암컷)를 (주)중앙실험동물로부터 이수한 후 약 1주일간의 순화 기간을 거친 후 일반적인 건강상태를 관찰하여 건강한 동물만을 시험에 사용하였다. 동물실의사육조건은 KFDA의 조건을 충족하는 충북대학교 실험동물연구지원센터에서 실험을 진행하였고 마우스용 사료(삼양사료)와 물은 자유로이 제공하였다. 동물 사육실은 온도 23 3℃, 상대 습도 50 10%, 12시간씩 밤낮을 유지하였다.Five-week-old mice (C57BL, females) were obtained from a central experimental animal, and after approximately one week of acclimation, the general state of health was observed and only healthy animals were used for the test. Animal breeding conditions were conducted at the Chungbuk National University Laboratory Animal Research Support Center, which satisfies the KFDA conditions. The feed for mice (Samyang Feed) and water were freely provided. Animal breeding room was maintained at a temperature of 23 3 ℃, relative humidity 50 10%, 12 hours each day.

발모 촉진 효능을 평가하기 위해, 등쪽 피부의 색이 분홍색을 보이는 휴지기 체모의 6주령을 사용하였다. 에니멀클리퍼(Animal clipper)를 이용하여 조심스럽게 쥐 등판의 털을 깎아내고, 깎은 부위에 붓을 사용하여 0.2ml의 시료를 충분히 도포한 후 약 3분간 마사지를 한 다음 증류수로 충분히 행구어 주었다. 시료 처리는 매일 1회씩 실시하였으며, 양성대조군에서 털이 자라 등을 완전히 덮은 상태인 3주 동안 관찰하였다.To evaluate the hair growth promoting effect, 6 week old of resting hairs in which the color of the dorsal skin is pink was used. The animal clipper was carefully trimmed with an animal clipper, 0.2 ml of sample was applied to the cut area using a brush, massaged for about 3 minutes, and rinsed thoroughly with distilled water. Sample treatment was performed once daily, and observed for 3 weeks while hairs were completely covered in the positive control group.

처리시료는 용매대조군(식염수), 식염수에 제조예 9에 따른 추출물 혼합물(JH-IJ AC 추출물) 10중량% 함유된 것, 5중량% 함유된 것, 및 양성대조군으로 미녹시딜 5.0 중량% 함유된 것을 사용하였다. Samples to be treated were 10% by weight of the solvent control group (saline), 10% by weight of the extract mixture according to Preparation Example 9 (JH-IJ AC extract), 5% by weight, and 5.0% by weight of minoxidil as the positive control. Used.

평가기준은 시험 개시일로부터 매 4일, 7일, 10일 및 14일 경과 후 실험동물을 펜토바비탈(pentobarbital)로 마취시키고 체모의 발육에 대한 사진 촬영을 하였으로 그 결과를 도 3에 나타내었다. 상기 체모 발육에 대한 결과는 하기 표 3에 기재된 바에 따라 판정하였으며, 평가 결과는 하기 표 4에 나타내었다.Evaluation criteria were anesthetized with pentobarbital every 4 days, 7 days, 10 days and 14 days after the start of the test and photographed on the development of hair. The results are shown in FIG. 3. . The results for the hair growth were determined as described in Table 3 below, and the evaluation results are shown in Table 4 below.

[표 3]TABLE 3

Figure 112007005025430-pat00003
Figure 112007005025430-pat00003

[표 4]TABLE 4

Figure 112007005025430-pat00004
Figure 112007005025430-pat00004

상기 표 4 및 도 3의 결과를 참고하면, 본 발명에 따른 조성물이 모발 성장 효과가 매우 우수함을 알 수 있다.Referring to the results of Table 4 and Figure 3, it can be seen that the composition according to the present invention is very excellent hair growth effect.

실험예Experimental Example 3. 발모실험 II(조직학 분석) 3. Hair Growth Experiment II (Histological Analysis)

마우스는 시험 종료일에 각각 2 마리씩 부검하였으며, 시료 도포 부위를 해부기를 이용하여 적출한 후 포르말린(formalin)으로 고정하였다. 단계별로 에탄올과 자일렌(xylene)으로 탈수처리한 후 파라핀으로 포매한 후, 조직절편기를 이용하여 5㎛의 절편을 만들어 다시 에탄올과 자일렌으로 파라핀을 제거하였다. 헤마톡실린 & 에오신(Hematoxylin & Eosin, H&E)으로 염색하여 광학현미경으로 모낭조직의 조직학적 변화를 관찰하였으며, 그 결과를 도 4에 나타내었다. 도 4의 (a)는 용매대조군, (b)는 제조예 9 추출물(10중량%), (c)는 제조예 9 추출물(5중량%), (d)는 미녹시딜(5.0wt%)의 결과를 나타낸 것이다. 본 발명에 따른 조성물을 적용한 결과 모낭 세포가 활성화 된 것을 알 수 있다.Two mice were autopsied at the end of the test, and the sample application site was extracted using an anatomical apparatus and fixed with formalin. After dehydration with ethanol and xylene in each step and embedded in paraffin, 5 μm sections were made using a tissue sectioner and paraffin was removed again with ethanol and xylene. Staining with hematoxylin & Eosin (H & E) was used to observe the histological changes of hair follicle tissues under an optical microscope. The results are shown in FIG. 4. Figure 4 (a) is a solvent control group, (b) the extract of Preparation Example 9 (10% by weight), (c) the extract of Preparation Example 9 (5% by weight), (d) results of minoxidil (5.0wt%) It is shown. As a result of applying the composition according to the invention it can be seen that the hair follicle cells are activated.

상기의 결과로부터 본 발명에 따른 탈모방지 및 모발 성장 촉진용 조성물은 화학물질인 미녹시딜을 유효성분으로 함유한 조성물에 비해 모낭 세포 활성화 및 모발 성장 촉진 효과가 우수함을 알 수 있으며, 본 발명에 따른 조성물의 유효 성분은 모두 천연물질에서 유래된 것으로서 장기 사용에 대한 부작용이 전혀 없으므로 미녹시딜과 같은 화학물질을 함유하는 조성물에 비해 화장품 등에 적용하기에 더욱 우수한 장점이 있다.From the above results, it can be seen that the composition for preventing hair loss and promoting hair growth according to the present invention has superior hair follicle cell activation and hair growth promoting effects compared to a composition containing the chemical minoxidil as an active ingredient, and the composition according to the present invention. Since all of the active ingredients are derived from natural materials and do not have any side effects on long-term use, there is an advantage that they are more excellent for applying to cosmetics and the like compared to compositions containing chemicals such as minoxidil.

본 발명에서는 홍삼, 방풍, 형개, 바이칼린, 고삼, 감초, 당귀, 김, 하수오, 승마, 및 소엽을 함유하여, 발모효과, 양모효과, 우수하며, 장기간 사용에도 부작용을 유발하지 않는 탈모방지 및 모발 성장 촉진용 조성물로서 화장품에 유용하게 적용할 수 있다.In the present invention, containing red ginseng, windproof, mold opening, Baikal, red ginseng, licorice, donkey, seaweed, sewage, horse riding, and lobule, hair growth effect, wool effect, excellent, prevent hair loss that does not cause side effects even in long-term use and It can be usefully applied to cosmetics as a composition for promoting hair growth.

Claims (4)

홍삼 추출물, 방풍 추출물, 형개 추출물, 바이칼린, 고삼 추출물, 감초 추출물, 당귀 추출물, 김 추출물, 하수오 추출물, 승마 추출물 및 소엽(蘇葉) 추출물을 함유하는 탈모 방지 및 모발 성장 촉진용 조성물.A composition for preventing hair loss and promoting hair growth, which comprises red ginseng extract, windproof extract, mold extract, Baikal, red ginseng extract, licorice extract, Angelica extract, seaweed extract, sewage extract, horse riding extract and leaflet extract. 제 1 항에 있어서,The method of claim 1, 상기 조성물은 홍삼 추출물 5 ~ 15 중량부, 방풍 추출물4 ~ 5 중량부, 형개 추출물 2 ~ 5 중량부, 바이칼린 0.5 ~ 15 중량부, 고삼 추출물 1 ~ 5 중량부, 감초 추출물 0.1 ~5 중량부, 당귀 추출물 0.5 ~ 5중량부, 김 추출물 5 ~ 15 중량부, 하수오 추출물 0.5 ~ 5 중량부, 승마 추출물 10 ~ 20 중량부, 및 소엽(蘇葉) 추출물 1 ~ 5 중량부의 혼합물을 함유하는 것을 특징으로 하는 탈모 방지 및 모발 성장 촉진용 조성물.The composition of the red ginseng extract 5 ~ 15 parts by weight, windproof extract 4 ~ 5 parts by weight, mold extract 2 ~ 5 parts by weight, Baikalin 0.5 ~ 15 parts by weight, red ginseng extract 1 ~ 5 parts by weight, licorice extract 0.1 ~ 5 parts by weight Containing 0.5 to 5 parts by weight of Angelica extract, 5 to 15 parts by weight of laver extract, 0.5 to 5 parts by weight of sewage extract, 10 to 20 parts by weight of horse riding extract, and 1 to 5 parts by weight of leaflet extract. Hair loss prevention and hair growth promoting composition characterized in. 제 1 항에 있어서,The method of claim 1, 상기 바이칼린은 황금을 에탄올 및 물의 혼합용매에 넣고 가열한 후 감압 농축하여 1차 추출물을 제조하는 단계, 상기 1차 추출물에 헥산을 첨가하여 불순물을 제거하는 단계, 불순물이 제거된 1차 추출물을 에틸아세테이트에 녹여 농축하는 단계, 및 재결정 단계를 통해서 제조된 것을 특징으로 하는 탈모 방지 및 모발 성장 촉진용 조성물.Wherein the Baikal is a golden solvent in a mixed solvent of ethanol and water, heated and concentrated under reduced pressure to prepare a primary extract, the step of removing impurities by adding hexane to the primary extract, the primary extract from which impurities are removed A composition for preventing hair loss and promoting hair growth, which is prepared by dissolving and concentrating in ethyl acetate and recrystallization. 제 3 항에 있어서,The method of claim 3, wherein 홍삼, 방풍, 고삼, 하수오 및 소엽(蘇葉)추출물은 각각 물:에탄올 1:1.2~4 중량비의 혼합용매로부터 추출된 것이며, 형개는 헥산:에탄올 1:2~10 중량비의 혼합용매로부터 추출한 것이고, 당귀 및 승마 추출물은 열수 추출한 것이며, 감초추출물은 에틸아세테이트로 추출한 것이고, 김 추출물은 열수 추출한 후 감압농축하고, 물:에탄올 1:1.2~4중량비의 혼합용매에서 재결정한 것을 특징으로 하는 탈모 방지 및 모발 성장 촉진용 조성물.The red ginseng, windbreak, ginseng, sewage and leaflet extracts were each extracted from a mixed solvent of water: ethanol 1: 1.2-4 weight ratio, and the type of extract was extracted from a mixed solvent of hexane: ethanol 1: 2-10 weight ratio. , Angelica extract and horse riding extract is extracted from hot water, licorice extract is extracted with ethyl acetate, seaweed extract is concentrated under reduced pressure after extraction of hot water, water: ethanol 1: 1.2 ~ 4 weight ratio to prevent hair loss characterized in that recrystallized in a mixed solvent And a composition for promoting hair growth.
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100930688B1 (en) * 2009-02-17 2009-12-09 주식회사 케레스코스메틱 Oriental composition for reinforcement of hair-roots and cleanness of scalp and its preparation method
EP2255782A1 (en) * 2009-05-25 2010-12-01 Keune Haircosmetics Manufacturing B.V. Composition for the prevention or treatment of hair loss, and method of preparation
KR101111132B1 (en) * 2009-01-06 2012-03-26 (주) 에이텍 Hair conditioning composition
KR101390108B1 (en) 2012-03-30 2014-04-28 김명숙 Cosmetic composition for preventing loss of hair containing nine times-steaming Ginseng extract and natural oriental medicine extracts
CN106265421A (en) * 2016-08-19 2017-01-04 黄亚景 A kind of hair oil

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KR20000031349A (en) * 1998-11-05 2000-06-05 박명규 Hair tonic manufactured from ginseng and manufacturing method thereof
KR20050013278A (en) * 2003-07-28 2005-02-04 황인명 Composition of stops the hair from falling out and the process

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000031349A (en) * 1998-11-05 2000-06-05 박명규 Hair tonic manufactured from ginseng and manufacturing method thereof
KR20050013278A (en) * 2003-07-28 2005-02-04 황인명 Composition of stops the hair from falling out and the process

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101111132B1 (en) * 2009-01-06 2012-03-26 (주) 에이텍 Hair conditioning composition
KR100930688B1 (en) * 2009-02-17 2009-12-09 주식회사 케레스코스메틱 Oriental composition for reinforcement of hair-roots and cleanness of scalp and its preparation method
EP2255782A1 (en) * 2009-05-25 2010-12-01 Keune Haircosmetics Manufacturing B.V. Composition for the prevention or treatment of hair loss, and method of preparation
KR101390108B1 (en) 2012-03-30 2014-04-28 김명숙 Cosmetic composition for preventing loss of hair containing nine times-steaming Ginseng extract and natural oriental medicine extracts
CN106265421A (en) * 2016-08-19 2017-01-04 黄亚景 A kind of hair oil

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