CN112826777A

CN112826777A - A cosmetic composition with skin permeation and hair blackening and anti-alopecia effects, and its preparation method

Info

Publication number: CN112826777A
Application number: CN202110046472.0A
Authority: CN
Inventors: 曹冬雨; 张娇; 韩志东
Original assignee: Quanhou Guangzhou Research Institute Of Biotechnology Co ltd
Current assignee: Quanhou Guangzhou Research Institute Of Biotechnology Co ltd
Priority date: 2021-01-13
Filing date: 2021-01-13
Publication date: 2021-05-25

Abstract

The invention provides a cosmetic composition capable of being absorbed through skin and having hair blackening and anti-hair loss effects and a preparation method thereof, and the hair care composition comprises the following components, by weight, 1-5 parts of fructus forsythiae extract, 1-5 parts of wild pueraria extract, 1-5 parts of rhizoma anemarrhenae root extract, 1-5 parts of folium ginkgo extract, 0.1-2 parts of centella asiatica leaf extract and 1-5 parts of ganoderma atrum extract. The cosmetic composition which can be absorbed through skin and has the effects of blackening hair and preventing alopecia has the following advantages of solving the problems of white hair and alopecia associated with many people, along with convenient use and low cost; the effective components are prepared into a microemulsion formula, so that the absorption efficiency of the effective components is greatly improved, and the problems of white hair turning into black hair and alopecia are effectively promoted to be solved.

Description

A cosmetic composition with skin permeation and hair blackening and anti-alopecia effects, and its preparation method

Technical Field

The invention relates to the field of cosmetics, in particular to a cosmetic composition which can be absorbed through skin and has the effects of blackening hair and preventing alopecia and a preparation method thereof.

Background

With the increase of age and external pressure, two problems of hair and scalp are accompanied, one is white hair increase, the other is alopecia, and many people are accompanied with the two problems at the same time, so that products of different types need to be used independently in a targeted manner, or white hair is changed into black hair, or anti-hair loss products are used independently, and if the two products are used simultaneously, the complexity and the cost of use are increased undoubtedly.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide a cosmetic composition which can be absorbed through skin and has the effects of blackening hair and preventing alopecia and a preparation method thereof.

In order to achieve the purpose, the invention adopts the technical scheme that: a hair care composition comprises, by weight, 1-5 parts of a forsythia suspense fruit extract, 1-5 parts of a wild pueraria extract, 1-5 parts of a rhizoma anemarrhenae root extract, 1-5 parts of a ginkgo leaf extract, 0.1-2 parts of a centella asiatica leaf extract and 1-5 parts of a ganoderma atrum extract.

The inventor discovers through research that the hair care composition can remarkably improve the hair blackening effect and the hair loss prevention effect of the hair care composition by matching the forsythia suspense fruit extract, the pueraria lobata extract, the rhizoma anemarrhenae root extract, the ginkgo leaf extract, the centella asiatica leaf extract and the ganoderma atrum extract, and plays a synergistic role.

Preferably, in the hair care composition, the weight ratio of the forsythia fruit extract to the pueraria lobata extract to the rhizoma anemarrhenae root extract to the ginkgo leaf extract to the centella asiatica leaf extract to the ganoderma atrum extract is as follows: wild kudzu root extract: rhizoma anemarrhenae root extract: ginkgo leaf extract: centella asiatica leaf extract: and (3) the ganoderma atrum extract is (1-3): (2-4): (1-3): (1-3): (0.5-1.5): (1-4).

Preferably, in the hair care composition, the weight ratio of the forsythia fruit extract to the pueraria lobata extract to the rhizoma anemarrhenae root extract to the ginkgo leaf extract to the centella asiatica leaf extract to the ganoderma atrum extract is as follows: wild kudzu root extract: rhizoma anemarrhenae root extract: ginkgo leaf extract: centella asiatica leaf extract: and (3) the ganoderma atrum extract is (1-3): (2-4): (1-3): (1-3): (0.5-1.2): 4.

the inventor finds that when the weight ratio of the forsythia suspense fruit extract, the pueraria lobata extract, the rhizoma anemarrhenae root extract, the ginkgo leaf extract, the asiatic pennywort herb leaf extract and the ganoderma atrum extract in the hair care composition meets the conditions, the hair blackening effect and the hair loss prevention effect of the hair care composition can be further improved.

The invention also provides a hair care cosmetic, which comprises the following components, by weight, 1% -5% of forsythia suspense fruit extract, 1% -5% of wild pueraria extract, 1% -5% of rhizoma anemarrhenae root extract, 1% -5% of ginkgo leaf extract, 0.1% -2% of asiatic pennywort herb leaf extract and 1% -5% of ganoderma atrum extract.

Preferably, the hair care cosmetic comprises the following components, by weight, 1% -3% of fructus forsythiae extract, 2% -4% of kudzu root extract, 1% -3% of rhizoma anemarrhenae root extract, 1% -3% of ginkgo leaf extract, 0.5% -1.5% of centella asiatica leaf extract and 1% -4% of ganoderma atrum extract.

Preferably, the cosmetic also comprises the following components, by weight, 5% -10% of 1, 2-pentanediol, 1% -5% of glycerin, 1% -5% of PEG-40 hydrogenated castor oil, 0.5% -10% of water-soluble pyrrolidinyl diaminopyrimidine oxide and 0.5% -10% of water-soluble diaminopyrimidine oxide.

According to the formula of the emulsion of the cosmetic, the prepared microemulsion preparation with the average particle size of (48.24 +/-3.73) nm and good stability at room temperature has good stability and high transdermal speed as shown by in-vitro transdermal experiment results; and the preparation method has simple operation, short preparation time and low requirement on equipment, and lays an experimental foundation for the preparation of the microemulsion used for the in vitro transdermal preparation.

Preferably, the cosmetic further comprises 1-5 wt% of GINSENG root water (97.5 wt% of GINSENG (PANAX GINSENG), 0.1-5 wt% of tetrapeptide palmitic acid-20, 1-5 wt% of radix polygoni multiflori extract (POLYGONUM MULTIFLORUM) root extract, 50 wt% of guangdong, 0.1-1 wt% of lactic acid and 0.1-1 wt% of menthol.

Preferably, the cosmetic also comprises the following components, by weight, 25-30% of oleic acid, 8-10% of TWEEN 80, 8-10% of ethanol and the balance of water.

According to the formula of the cosmetic emulsion, after the emulsion is transdermally administered, the lipophilic region of the emulsion can interact with the stratum corneum, and the drug dissolved in the lipophilic region can directly diffuse into the lipid of the stratum corneum. These interactions can promote drug permeation. Tests show that the transdermal capacity of the microemulsion group is 5-15 times higher than that of a control group (aqueous solution).

Preferably, the hair care cosmetic is emulsion, the average particle size of the emulsion is 40-55 nm, and the pH value of the emulsion is 5.5-6.0.

The present invention also provides a method for preparing a hair care cosmetic, comprising the steps of:

(1) evenly mixing oleic acid and tween-80 according to a weight ratio to obtain an oil phase;

(2) dissolving glycerol, 1, 2-pentanediol, water-soluble pyrrolidinyl diaminopyrimidine oxide, water-soluble diaminopyrimidine oxide, folium Ginkgo extract, Ginseng radix water, folium Centellae extract, tetrapeptide palmitic acid-20, Polygoni Multiflori radix extract and Ganoderma extract in distilled water; simultaneously, PEG-40 hydrogenated castor oil is used for solubilizing menthol, forsythia suspense fruit extract, kudzu root extract and rhizoma anemarrhenae root extract until the mixture is transparent, and then the mixture is added into a water phase;

(3) slowly dropwise adding the water phase into the oil phase at room temperature, simultaneously dropwise adding co-emulsifier ethanol, magnetically stirring, and ultrasonically removing bubbles until the solution is a clear thick liquid;

(4) adding lactic acid to adjust the pH value to 5.5-6.0 to obtain the microemulsion of the cosmetic composition which can be transdermally absorbed and has the effects of blackening hair and preventing alopecia.

According to the formula of the emulsion of the cosmetic, the prepared microemulsion preparation with the average particle size of (48.24 +/-3.73) nm and good stability at room temperature has good stability and high transdermal speed as shown by in-vitro transdermal experiment results; and the preparation method has simple operation, short preparation time and low requirement on equipment, and lays an experimental foundation for the preparation of the microemulsion used for the in vitro transdermal preparation. After the microemulsion is transdermally administered, a lipophilic region of the microemulsion can interact with a horny layer, and a drug dissolved in the lipophilic region can directly diffuse into lipid of the horny layer, while a hydrophilic region of the microemulsion can improve hydration of the horny layer, and an aqueous phase of the microemulsion flows into a polar region to cause evacuation of a horny layer protein structure, resulting in destruction of an interface structure. These interactions can promote drug permeation. The test shows that the skin penetration of the microemulsion group is 5-15 times higher than that of the control group (aqueous solution).

The invention has the beneficial effects that: the cosmetic composition with the functions of blackening hair and preventing alopecia simultaneously through skin permeation absorption has the following advantages, simultaneously solves the problems of white hair and alopecia associated with many people, and is convenient to use and low in cost; the effective components are prepared into a microemulsion formula, so that the absorption efficiency of the effective components is greatly improved, and the problems of white hair turning into black hair and alopecia are effectively promoted to be solved.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.

The invention provides a cosmetic composition which can be absorbed through skin and has the effects of blackening hair and preventing alopecia simultaneously, which comprises the following components in percentage by weight:

the balance of water;

25 to 30 percent of oleic acid;

TWEEN 80 8％～10％；

8 to 10 percent of ethanol;

5 to 10 percent of 1, 2-pentanediol;

1% -5% of glycerol;

1 to 5 percent of PEG-40 hydrogenated castor oil;

0.5 to 10 percent of water-soluble pyrrolidinyl diaminopyrimidine oxide;

0.5 to 10 percent of water-soluble diaminopyrimidine oxide;

1 to 5 percent of forsythia suspense fruit extract;

1 to 5 percent of wild pueraria extract;

1 to 5 percent of rhizoma anemarrhenae extract;

1-5% of ginkgo leaf extract;

1 to 5 percent of ginseng root water;

0.1-2.0% of asiatic pennywort herb leaf extract;

tetrapeptide palmitic acid-200.1% -5%;

1 to 5 percent of fleece-flower root extract;

1 to 5 percent of ganoderma atrum extract;

0.1 to 1 percent of lactic acid;

0.1 to 1 percent of menthol.

Specifically, the formulations of examples 1 to 4, comparative examples 1 to 5 and placebo are shown in table 1.

TABLE 1 formulations of examples 1-4, comparative examples 1-4 and placebo

In table 1, GINSENG root water (97.5% content, PANAX GINSENG root water), and POLYGONUM MULTIFLORUM extract (POLYGONUM MULTIFLORUM) root extract, guangzhou yueze, 50% content) were listed.

The preparation method of the hair care cosmetic provided by the embodiment of the invention comprises the following steps of:

(4) adding lactic acid to adjust the pH value to 5.5-6.0; the microemulsion of the cosmetic composition can be absorbed through skin and has the effects of blackening hair and preventing alopecia.

Preparation method of comparative example corresponding components were omitted according to the preparation methods of the above examples.

Effect testing

1. And (3) stability investigation: the microemulsion of the cosmetic composition having the effects of blackening hair and preventing hair loss, which is absorbed through skin, of the example was bottled and placed in 3 cold and hot circulation boxes at 50 ℃, 45 ℃, 40 ℃, 4 ℃, minus 18 ℃, 25 ℃, TL84 light source illumination and-18 ℃ to 50 ℃ for stability examination for 3 months, and the results showed that the essence has good stability.

2. Performance testing

First, basic information

1. Details of the subjects: a total of 314 testers with alopecia and canities, age 35-50 years, were divided into 10 groups, 14 of which were dropped midway, and the final effective number was 300

2. Details of the experiment: using the product in a corresponding area according to requirements, using the test sample in the morning and evening, and carrying out seven times of photo collection/hair loss collection of the test area in the test period, wherein the photo collection/hair loss collection is respectively collected before the product is used, and the photo collection/hair loss collection is carried out for 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks and 12 weeks; the questionnaire survey was carried out three times in total, 1 month, 2 months, and 3 months of the product use.

3. Testing indexes are as follows:

the hair loss test index is as follows: the change situation before and after the use of the photo is evaluated by adopting a 5-segment method: significant improvement-slight improvement-invariant-worsening; evaluating the effect of the product according to the change condition of the hair number before and after hair dropping and collection; third, the effect of the product is evaluated by the self-evaluation condition of the subject

The test indexes of white hair to black hair are as follows: scalp pictures were taken at T0 and 3 months. A blind evaluation was then carried out to assess the proportion of white hairs (percentage of white hairs on a fixed separate area on the hair), two parameters were measured, scoring the proportion of white hairs, quantifying the density of white hairs

Second, efficacy analysis

1. Subject self-evaluation

The subject carried out a questionnaire type self-evaluation of subjective feeling of product effect according to the conditions of alopecia and canities per month

2. Hair loss collection

The hair loss of each subject was collected at 0 week, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, and 12 weeks, respectively, and the hair loss was counted

3. Photographic observation of baldness and white hair areas

The results of the three comprehensive test methods are shown in Table 2.

TABLE 2 alopecia prevention efficacy of microemulsions of cosmetic compositions having skin-permeable absorption while having hair blackening and alopecia prevention efficacy

	The number of people cured	Number of effective persons	Number of invalid persons
				Example 1	53％	19％	28％
Example 2	28％	48％	24％
				Example 3	45％	36％	19％
Example 4	38％	29％	21％
				Comparative example 1	24％	28％	48％
Comparative example 2	16％	31％	53％
				Comparative example 3	43％	28％	29％
Comparative example 4	38％	34％	28％
				Comparative example 5	26％	47％	27％
Placebo	0	0	100％

TABLE 3 Hair whitening and blackening effects of microemulsion of cosmetic composition capable of being absorbed through skin and simultaneously having hair blackening and anti-alopecia effects

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. The hair care composition is characterized by comprising, by weight, 1-5 parts of fructus forsythiae extract, 1-5 parts of wild pueraria extract, 1-5 parts of rhizoma anemarrhenae root extract, 1-5 parts of folium ginkgo extract, 0.1-2 parts of centella asiatica leaf extract and 1-5 parts of ganoderma atrum extract.

2. The hair care composition according to claim 1, wherein the weight ratio of the forsythia fruit extract, the pueraria lobata extract, the rhizoma anemarrhenae root extract, the ginkgo biloba leaf extract, the asiatic pennywort leaf extract and the ganoderma atrum extract in the forsythia fruit extract: wild kudzu root extract: rhizoma anemarrhenae root extract: ginkgo leaf extract: centella asiatica leaf extract: and (3) the ganoderma atrum extract is (1-3): (2-4): (1-3): (1-3): (0.5-1.5): (1-4).

3. The hair care composition according to claim 2, wherein the weight ratio of the forsythia fruit extract, the pueraria lobata extract, the rhizoma anemarrhenae root extract, the ginkgo biloba leaf extract, the asiatic pennywort leaf extract and the ganoderma atrum extract in the forsythia fruit extract: wild kudzu root extract: rhizoma anemarrhenae root extract: ginkgo leaf extract: centella asiatica leaf extract: and (3) the ganoderma atrum extract is (1-3): (2-4): (1-3): (1-3): (0.5-1.2): 4.

4. the hair care cosmetic is characterized by comprising 1-5 wt% of forsythia suspense fruit extract, 1-5 wt% of wild pueraria extract, 1-5 wt% of rhizoma anemarrhenae root extract, 1-5 wt% of ginkgo leaf extract, 0.1-2 wt% of asiatic centella leaf extract and 1-5 wt% of ganoderma atrum extract.

5. The hair care cosmetic according to claim 4, wherein the hair care cosmetic comprises 1-3% by weight of forsythia suspensa fruit extract, 2-4% by weight of pueraria lobata extract, 1-3% by weight of rhizoma anemarrhenae root extract, 1-3% by weight of ginkgo biloba extract, 0.5-1.5% by weight of centella asiatica leaf extract and 1-4% by weight of ganoderma atrum extract.

6. A hair care cosmetic according to claim 4 or 5, characterized in that it further comprises, in weight percent, 5% to 10% of 1, 2-pentanediol, 1% to 5% of glycerin, 1% to 5% of PEG-40 hydrogenated castor oil, 0.5% to 10% of water-soluble pyrrolidinyl diaminopyrimidine oxide and 0.5% to 10% of water-soluble diaminopyrimidine oxide.

7. The hair care cosmetic according to claim 6, further comprising 1 to 5% of ginseng root water, 0.1 to 5% of tetrapeptide palmitic acid-20, 1 to 5% of fleece-flower root extract, 0.1 to 1% of lactic acid and 0.1 to 1% of menthol by weight.

8. The hair care cosmetic according to claim 7, further comprising, by weight, 25 to 30% of oleic acid, 8 to 10% of TWEEN 80, 8 to 10% of ethanol and the balance water.

9. The hair care cosmetic according to claim 4 or 5, wherein the hair care cosmetic is an emulsion having an average particle diameter of 40 to 55nm and a pH of 5.5 to 6.0.

10. A process for the preparation of a hair care cosmetic according to claim 8 or 9, which comprises the steps of: