CN111759769A - Composition with effects of whitening, removing wrinkles and preserving moisture, preparation method and use method - Google Patents
Composition with effects of whitening, removing wrinkles and preserving moisture, preparation method and use method Download PDFInfo
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- 230000037303 wrinkles Effects 0.000 title claims abstract description 28
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 230000002087 whitening effect Effects 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims description 16
- 238000000034 method Methods 0.000 title claims description 13
- 230000000694 effects Effects 0.000 title claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 57
- 241000220317 Rosa Species 0.000 claims abstract description 40
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 19
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960000458 allantoin Drugs 0.000 claims abstract description 19
- 239000000341 volatile oil Substances 0.000 claims abstract description 19
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 18
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 10
- 240000003109 Persicaria chinensis Species 0.000 claims abstract 8
- 238000003756 stirring Methods 0.000 claims description 40
- 239000000706 filtrate Substances 0.000 claims description 23
- 238000001914 filtration Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 241001506371 Kadsura Species 0.000 claims description 5
- 241000207925 Leonurus Species 0.000 claims 1
- 239000003245 coal Substances 0.000 claims 1
- 230000007774 longterm Effects 0.000 abstract description 2
- 229960004063 propylene glycol Drugs 0.000 abstract description 2
- 230000009759 skin aging Effects 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract 1
- 244000001545 Polygonum chinense Species 0.000 description 22
- 238000012360 testing method Methods 0.000 description 20
- 210000003491 skin Anatomy 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 12
- 210000000434 stratum corneum Anatomy 0.000 description 8
- 206010013786 Dry skin Diseases 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000219050 Polygonaceae Species 0.000 description 1
- 241001377695 Polygonum arenastrum Species 0.000 description 1
- 235000010728 Polygonum aviculare subsp aviculare Nutrition 0.000 description 1
- 235000010105 Polygonum aviculare subsp depressum Nutrition 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
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- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
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- 238000011990 functional testing Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Gerontology & Geriatric Medicine (AREA)
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- Cosmetics (AREA)
Abstract
The invention provides a composition with whitening, wrinkle-removing and moisturizing effects, which consists of a Chinese knotweed extract, rose hydrosol, allantoin, nicotinamide, propylene glycol, rose essential oil, EDTA and water. The invention has soft texture, no stimulation to skin, long-term use, safety and effectiveness. The whitening cream contains whitening components, can make the skin glow, can effectively remove wrinkles, improve the skin aging condition and effectively lock the moisture of the skin cuticle, thereby keeping the skin moist and preventing the skin from being rough.
Description
Technical Field
The invention relates to the field of cosmetic skin care, in particular to a composition with effects of whitening, removing wrinkles and moisturizing, a preparation method and a use method.
Background
With the improvement of living standard, people seek more diversified ways for beauty, and have higher attention on whitening skin care products developed by natural medicines. At present, the new generation of whitening skin care products pay more attention to compounding of various whitening active substances to generate a synergistic effect. The whitening components extracted from Chinese herbal medicines are gradually hot in the cosmetic industry due to the characteristics of mild skin, small irritation, stable drug property, high safety, lasting drug efficacy and the like.
In recent years, Chinese knotweed has started to be applied to health food and traditional medicine industries, in particular to the preparation of medicines for resisting inflammation, easing pain and detoxifying, but the application of Chinese knotweed in the aspect of cosmetic whitening is rarely reported.
At present, a composition which takes Chinese knotweed as a raw material and has the effects of whitening, removing wrinkles and moisturizing is not found.
Disclosure of Invention
The invention aims to provide a composition with the effects of whitening, removing wrinkles and moisturizing, a preparation method and a using method.
In order to achieve the purpose, the invention provides a composition with whitening, wrinkle-removing and moisturizing effects, which consists of a Chinese knotweed extract, rose hydrosol, allantoin, nicotinamide, propylene glycol, rose essential oil, EDTA and water.
Preferably, the composition consists of 50-60 wt% of Chinese knotweed extract, 10-15 wt% of rose hydrosol, 4-8 wt% of allantoin, 3-4 wt% of nicotinamide, 1-2 wt% of propylene glycol, 2-3 wt% of rose essential oil, 1-2 wt% of EDTA and water which are supplemented to 100 wt%.
In one embodiment, the composition consists of 50 wt% of kadsura root extract, 15 wt% of rose hydrosol, 4 wt% of allantoin, 4 wt% of nicotinamide, 2 wt% of propylene glycol, 3 wt% of rose essential oil, 1 wt% of EDTA, and water supplemented to 100 wt%.
In one embodiment, the composition consists of 55 wt% of kadsura root extract, 10 wt% of rose hydrosol, 6 wt% of allantoin, 3 wt% of nicotinamide, 1 wt% of propylene glycol, 2 wt% of rose essential oil, 2 wt% of EDTA, and water supplemented to 100 wt%.
In one embodiment, the composition consists of 60 wt% of kadsura root extract, 10 wt% of rose hydrosol, 8 wt% of allantoin, 3 wt% of nicotinamide, 1 wt% of propylene glycol, 2 wt% of rose essential oil, 1 wt% of EDTA, and water supplemented to 100 wt%.
The invention also provides a preparation method of the composition with the effects of whitening, removing wrinkles and moisturizing, which comprises the following steps:
(1) adding 30-35 parts of Chinese knotweed herb powder into 10-15 times of water, extracting for 45-60 min at 90-100 ℃, and filtering to obtain filtrate a; adding water with the amount being 10-15 times of that of the second time, extracting for 30-50 min at 90-100 ℃, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.3-0.5 g/mL to obtain a Chinese knotweed extract;
(2) adding water with the temperature of 40-50 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the Chinese knotweed extract obtained in the step (1), allantoin and propylene glycol, and continuously stirring for 25-35 min;
(4) sequentially adding nicotinamide, rose essential oil and EDTA, and continuously stirring for 15-25 min;
(5) and sequentially adding rose hydrosol, continuously stirring for 10-15 min, and stopping stirring to obtain the rose essence.
In some of these embodiments, the method comprises the steps of:
(1) adding 30 parts of Chinese knotweed herb powder into 15 times of water, extracting for 45min at 100 ℃, and filtering to obtain filtrate a; adding 10 times of water for the second time, extracting at 100 deg.C for 30min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.5g/mL to obtain the Chinese knotweed extract;
(2) adding water with the temperature of 40 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the Chinese knotweed extract obtained in the step (1), allantoin and propylene glycol, and continuously stirring for 25 min;
(4) sequentially adding nicotinamide, rose essential oil and EDTA, and continuously stirring for 15 min;
(5) sequentially adding rose hydrosol, stirring for 10min, and stopping stirring.
In some of these embodiments, the method comprises the steps of:
(1) adding 35 parts of Chinese knotweed herb powder into 15 times of water, extracting for 60min at 90 ℃, and filtering to obtain filtrate a; adding 10 times of water for the second time, extracting at 90 deg.C for 50min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.3g/mL to obtain the Chinese knotweed extract;
(2) adding water with the temperature of 50 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the Chinese knotweed extract obtained in the step (1), allantoin and propylene glycol, and continuously stirring for 35 min;
(4) sequentially adding nicotinamide, rose essential oil and EDTA, and continuously stirring for 25 min;
(5) sequentially adding rose hydrosol, stirring for 15min, and stopping stirring.
The invention also provides a use method of the composition with the effects of whitening, removing wrinkles and moisturizing, wherein the composition is used every day for at least 4 weeks.
Preferably, the method is such that the composition is administered daily for at least 8 weeks.
The medicinal herb of Chinese knotweed used in the invention is dry overground part of Chinese knotweed (Polygonum chinense L.) which is a polygonaceae plant.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention has soft texture, no stimulation to skin, long-term use, safety and effectiveness.
2. The invention contains whitening components and can make the skin glow.
3. The invention can effectively remove wrinkles and improve the skin aging condition.
4. The invention can effectively lock the moisture of the skin stratum corneum, thereby keeping the skin moist and preventing the skin from being rough.
Detailed Description
Example 1
(1) Adding 30g of the Chinese knotweed herb powder into 15 times of water, extracting for 45min at 100 ℃, and filtering to obtain filtrate a; adding 10 times of water for the second time, extracting at 100 deg.C for 30min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.5g/mL to obtain the Chinese knotweed extract;
(2) adding water with the temperature of 40 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the Chinese knotweed extract obtained in the step (1), allantoin and propylene glycol, and continuously stirring for 25 min;
(4) sequentially adding nicotinamide, rose essential oil and EDTA, and continuously stirring for 15 min;
(5) sequentially adding rose hydrosol, stirring for 10min, and stopping stirring.
Example 2
(1) Adding 35g of the pyrocarbon mother medicinal material powder into 15 times of water, extracting for 60min at 90 ℃, and filtering to obtain filtrate a; adding 10 times of water for the second time, extracting at 90 deg.C for 50min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.3g/mL to obtain the Chinese knotweed extract;
(2) adding water with the temperature of 50 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the Chinese knotweed extract obtained in the step (1), allantoin and propylene glycol, and continuously stirring for 35 min;
(4) sequentially adding nicotinamide, rose essential oil and EDTA, and continuously stirring for 25 min;
(5) sequentially adding rose hydrosol, stirring for 15min, and stopping stirring.
Example 3
The amounts are shown in Table 1, and the preparation method is the same as that of example 1.
Comparative example
The amounts are shown in Table 1, and the preparation method is the same as that of example 2.
TABLE 1
| Type of Material (wt%) | Example 1 | Example 2 | Example 3 | Comparative example |
| Herb of common knotweed extract | 50 | 55 | 60 | / |
| Rose pure dew | 15 | 10 | 10 | 15 |
| Allantoin | 4 | 6 | 8 | 4 |
| Nicotinamide | 4 | 3 | 3 | 4 |
| Propylene glycol | 2 | 1 | 1 | 2 |
| Rose essential oil | 3 | 2 | 2 | 3 |
| EDTA | 1 | 2 | 1 | 1 |
| Water (W) | To 100 of | To 100 of | To 100 of | To 100 of |
Functional test for wrinkle removing effect
First, laboratory glassware
MSC1001 stratum corneum moisture content tester, Delfin corporation, finland; cutometer @ dual MPA580 skin elasticity tester, CK company, germany; primos rapid three-dimensional imaging system for skin, LMI corporation, usa; VISIA-CR facial image analysis System, Canfield, USA.
Second, the experimental subject
45 healthy volunteers were selected. Inclusion criteria were: firstly, the age is between 30 and 65 years (except pregnant or lactating women); ② obvious dry lines or wrinkles on eyes; ③ patients without serious system diseases, immunodeficiency or autoimmune diseases; patients with no active allergic diseases; patients without constitutional hypersensitivity; sixthly, hormone medicines and immunosuppressants are not used in one month; and the tested part does not participate in other clinical trials at present or in the last three months. Termination and rejection criteria: firstly, volunteers require to stop the test for personal reasons; the volunteers have adverse reactions so that the test cannot be continued; and the volunteers have poor compliance, such as using other skin care products which have influence on the test.
Third, Experimental methods
The skin around the left or right eye was randomly selected as the example 1 group and the skin around the other eye was selected as the comparative example group from 30 volunteers on the random double-blind basis. The volunteers used the corresponding products 1 time each day, morning and evening, for 8 weeks, and were not used with other wrinkle-removing skin care products during the test period. Visits were 1 at 0, 2, 4 and 8 weeks for 4 total. Before each test, a subject needs to clean eyes with clear water, uses a paper towel without fluorescent agent to wipe dry the moisture of the eyes, sits still for at least 20min under a constant temperature and humidity environment (20-22 ℃ and relative humidity of 40-60 percent), and is measured by a measurer. Measuring the positions of fixed areas around the left eye and the right eye of a volunteer by using a stratum corneum moisture content tester and a skin elasticity tester respectively, recording stratum corneum moisture content values, and measuring each measuring area for 3 times and taking an average value; measuring wrinkle skin positions around the left eye and the right eye of the volunteer by using a rapid three-dimensional imaging system Primos of the skin, and recording a roughness Sa value and a wrinkle volume; eye images of the front, right and left sides of the volunteer were photographed using an eye image analyzer VISIA-CR, and the ratio of the wrinkle area was analyzed.
Fourth, statistical method
Data analysis was performed using SPSS19.0 statistical software. Values at 0, 2, 4 and 8 weeks were compared using the t-test or rank-sum test and subjected to significance analysis. P < 0.05 indicates that the difference is statistically significant.
Fifth, experimental results
1. Stratum corneum moisture content test
Table 2 stratum corneum moisture test results (n ═ 45)
As can be seen from table 2, the moisture content of the stratum corneum after the test period in the test subjects used the example 1 group showed a tendency to increase, and at weeks 4 and 8, the example 1 group data was higher than the comparative group, but there was no significant difference, but at week 8 was significantly higher than the moisture content of the stratum corneum just after use, and there was no significant difference in the comparative group.
2. Skin roughness test
Table 3 skin roughness test results (n ═ 45)
The skin roughness Sa value represents the arithmetic mean of the height of each point in the test range, and the lower the index value, the smaller the skin roughness and the smoother the skin. As can be seen from table 3, the skin roughness Sa value of the subject showed a decreasing trend after using the example 1 group in the test period, and started to be lower than that of the comparative example group at weeks 4 and 8, but there was no significant difference; at week 8, however, the skin roughness Sa after use of example 1 was already significantly lower than that immediately after use, and was not significantly different by the comparative example group.
3. Wrinkle volume test
Table 4 wrinkle volume test results (n ═ 45)
The wrinkle volume value represents the volume size of wrinkles in the analysis area, and the lower the index value, the smaller the wrinkle volume and the fewer wrinkles. As can be seen from table 4, the wrinkle volume values tended to decrease after the subjects used the example 1 group during the test period and began to fall below the comparative example group at weeks 4 and 8, but there was no significant difference; at week 8, however, the wrinkle volume value after use of example 1 was already significantly lower than that immediately after use, and no significant difference was observed in the comparative example.
4. Wrinkle area ratio test
Table 5 wrinkle area ratio test results (n ═ 45)
As can be seen from table 5, the wrinkle area of the subjects used the example 1 group tended to decrease during the test period, and no significant difference was observed between the example 1 group and the comparative example group, but the wrinkle area was already significantly lower at week 8 than at the beginning of the use of example 1, and no significant difference was observed between the comparative example group and the comparative example group.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (9)
1. The composition with the effects of whitening, removing wrinkles and moisturizing is characterized by comprising 50-60 wt% of Chinese knotweed extract, 10-15 wt% of rose hydrosol, 4-8 wt% of allantoin, 3-4 wt% of nicotinamide, 1-2 wt% of propylene glycol, 2-3 wt% of rose essential oil, 1-2 wt% of EDTA and 100 wt% of water.
2. The composition of claim 1, wherein the composition consists of 50 wt% of kadsura root extract, 15 wt% of rose hydrosol, 4 wt% of allantoin, 4 wt% of nicotinamide, 2 wt% of propylene glycol, 3 wt% of rose essential oil, 1 wt% of EDTA, and water supplemented to 100 wt%.
3. The composition of claim 1, wherein the composition consists of 55 wt% of kadsura root extract, 10 wt% of rose hydrosol, 6 wt% of allantoin, 3 wt% of nicotinamide, 1 wt% of propylene glycol, 2 wt% of rose essential oil, 2 wt% of EDTA, and water supplemented to 100 wt%.
4. The composition of claim 1, wherein the composition consists of 60 wt% of turkey mother extract, 10 wt% of rose hydrosol, 8 wt% of allantoin, 3 wt% of nicotinamide, 1 wt% of propylene glycol, 2 wt% of rose essential oil, 1 wt% of EDTA, and water supplemented to 100 wt%.
5. A method for preparing the composition with whitening, wrinkle-removing and moisturizing effects according to any one of claims 1 to 4, characterized by comprising the following steps:
(1) adding 30-35 parts of Chinese knotweed herb powder into 10-15 times of water, extracting for 45-60 min at 90-100 ℃, and filtering to obtain filtrate a; adding water with the amount being 10-15 times of that of the second time, extracting for 30-50 min at 90-100 ℃, and filtering to obtain filtrate b; and combining the two filtrates, and concentrating under reduced pressure to 0.3-0.5 g/mL to obtain the leonurus kamtschaticus extract.
(2) Adding water with the temperature of 40-50 ℃ according to the formula proportion into a preparation container, and starting stirring.
(3) And (2) sequentially adding the charred coal extract obtained in the step (1), allantoin and propylene glycol, and continuously stirring for 25-35 min.
(4) Sequentially adding nicotinamide, rose essential oil and EDTA, and continuously stirring for 15-25 min.
(5) And sequentially adding rose hydrosol, continuously stirring for 10-15 min, and stopping stirring to obtain the rose essence.
6. The method according to claim 5, characterized in that it comprises the steps of:
(1) adding 30 parts of Chinese knotweed herb powder into 15 times of water, extracting for 45min at 100 ℃, and filtering to obtain filtrate a; adding 10 times of water for the second time, extracting at 100 deg.C for 30min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.5g/mL to obtain the Chinese knotweed extract;
(2) adding water with the temperature of 40 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the Chinese knotweed extract obtained in the step (1), allantoin and propylene glycol, and continuously stirring for 25 min;
(4) sequentially adding nicotinamide, rose essential oil and EDTA, and continuously stirring for 15 min;
(5) sequentially adding rose hydrosol, stirring for 10min, and stopping stirring.
7. The method according to claim 5, characterized in that it comprises the steps of:
adding 10 times of water for the second time, extracting at 90 deg.C for 50min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.3g/mL to obtain the Chinese knotweed extract;
(2) adding water with the temperature of 50 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the Chinese knotweed extract obtained in the step (1), allantoin and propylene glycol, and continuously stirring for 35 min;
(4) sequentially adding nicotinamide, rose essential oil and EDTA, and continuously stirring for 25 min;
(5) sequentially adding rose hydrosol, stirring for 15min, and stopping stirring.
8. A method for using a composition with the effects of whitening, removing wrinkles and moisturizing, which is characterized by comprising the following steps: the composition is administered daily for at least 4 weeks.
9. Use according to claim 8, characterized in that the method is: the composition is administered daily for at least 8 weeks.
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| CN202010767029.8A CN111759769A (en) | 2020-08-03 | 2020-08-03 | Composition with effects of whitening, removing wrinkles and preserving moisture, preparation method and use method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116172929A (en) * | 2023-03-23 | 2023-05-30 | 植物医生(广东)生物科技有限公司 | Whitening composition and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523536A (en) * | 2015-01-24 | 2015-04-22 | 黄荣波 | Whitening and moisturizing cosmetic containing Asiatic pennywort herb extract and preparation method of whitening and moisturizing cosmetic |
| CN108853404A (en) * | 2018-07-24 | 2018-11-23 | 近晟（上海）医药科技有限公司 | A kind of compound Chinese medicinal preparation and preparation method thereof for treating skin and mucous membrane disease |
-
2020
- 2020-08-03 CN CN202010767029.8A patent/CN111759769A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523536A (en) * | 2015-01-24 | 2015-04-22 | 黄荣波 | Whitening and moisturizing cosmetic containing Asiatic pennywort herb extract and preparation method of whitening and moisturizing cosmetic |
| CN108853404A (en) * | 2018-07-24 | 2018-11-23 | 近晟（上海）医药科技有限公司 | A kind of compound Chinese medicinal preparation and preparation method thereof for treating skin and mucous membrane disease |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116172929A (en) * | 2023-03-23 | 2023-05-30 | 植物医生(广东)生物科技有限公司 | Whitening composition and preparation method and application thereof |
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