KR102450173B1 - Cosmetic composition for moisturizing facial skin and alleviating swelling - Google Patents

Abstract

It relates to a cosmetic composition for moisturizing and relieving swelling of the facial skin that is made of plant-derived ingredients to help strengthen the skin barrier and relieve puffiness of the facial area (cheek area and eyelid area) to maintain firm and moist skin, Panthenol, By preparing a composition containing arnica montana flower extract, ceramide NP, and Mugunghwa bark extract as active ingredients, it relieves puffiness of the facial area (cheek area and eyelid area) to maintain firm and moist skin.

Description

Cosmetic composition for moisturizing facial skin and alleviating swelling

The present invention relates to a cosmetic composition for moisturizing and alleviating swelling of the facial skin, and in particular, it is prepared with plant-derived ingredients to help strengthen the skin barrier and relieve swelling of the facial part (cheek area and eyelid area) to maintain firm and moist skin It relates to a cosmetic composition for moisturizing the skin of the face and alleviating swelling.

In general, the most important role of the skin is to prevent heat and moisture loss from the inside while serving as a defense barrier to protect the skin from external bacterial invasion and damage. The skin is composed of several layers, the outermost of which is called the epidermis, and it is classified into three parts: the dermis and the subcutaneous fat layer below it. In addition, the epidermis is subdivided into the stratum corneum, granular layer, stratum corneum, and basal layer, and epidermal cells generated in the basal layer rise to the granular layer in 14 days, and keratinization begins in the granular layer by the action of keratohyalin.

The most important function of the epidermis, which is located in the outermost part of the skin, is to protect against various external stimuli, for example, chemical substances, air pollutants, dry environment, and physical and chemical irritants such as ultraviolet rays, and protect the body through the skin. It is a protective function that prevents excessive evaporation of moisture, and this protective function can be maintained only when the stratum corneum composed of keratinocytes is normally formed.

In addition, the stratum corneum (horney layer) is formed from keratinocytes, and consists of keratinocytes whose differentiation has been completed and a lipid layer surrounding them. Keratinocytes are characteristic cells in which basal cells, which continuously proliferate in the lowermost layer of the epidermis, undergo morphological and functional changes in stages, and rise to the surface of the skin. They are eliminated and new keratinocytes take over their functions. This repetitive series of changes is called "differentiation of epidermal cells" or "keratinization". During the keratinization process, keratinocytes form the stratum corneum while generating Natural Moisturizing Factor (NMF) and intercellular lipids (ceramide, cholesterol, fatty acids), thereby making the stratum corneum firm and flexible, thereby providing a skin barrier. ) to retain its function.

However, the stratum corneum can easily lose its function due to lifestyle factors such as excessive washing or bathing, environmental factors such as dry air and pollutants, and intrinsic diseases such as atopic skin or senile skin. In recent years, the number of people complaining of dry skin symptoms and various disorders caused by it is increasing. Therefore, many studies have been conducted to supply moisture from the outside in order to maintain proper skin moisture or to prevent moisture loss from the body. It is widely used in the field.

On the other hand, a method of increasing moisture retention in the stratum corneum by using a humectant having a property of absorbing moisture as a humectant and an occlusive moisturizer preventing moisture evaporation is widely used. Moisturizing ingredients include substances such as glycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol as polyols, and lipid components such as ceramide, essential fatty acids and lipid complexes are used as sealing ingredients (J InvestDermatol) (5), 731-740, 1994).

An example of such a technique is disclosed in Documents 1 to 3 and the like.

For example, in Patent Document 1 below, gluconolactone as a material for exfoliation; Selected from the group consisting of burdock seed extract, alanylglutamine, acetyltetrapeptide-15, arnica flower extract, brown algae extract, panthenol, and beta-glucan with nutmeg extract to relieve skin nerve irritation symptoms caused by gluconolactone At least one natural moisturizing agent selected from the group consisting of an anti-inflammatory complex, and urea, amino acid, pyrrolidone carboxylic acid (PCA), sodium hyaluronate, lactate, glucosamine, potassium ion, sodium ion, and calcium ion. Disclosed is a cosmetic composition for exfoliating the skin including factors.

In addition, in Patent Document 2, jasmine extract, arnica extract and yarrow extract contain 0.01 to 60% by weight based on the total weight of the cosmetic composition, and the weight ratio of the jasmine extract, arnica extract and yarrow extract is 5.5 to 6.5: 1.75 to 2.25: 1.75 It is disclosed for a cosmetic composition for moisturizing of ~2.25.

On the other hand, in Patent Document 3, 1 to 5% by weight of cetyl ethylhexanoate, 1 to 5% by weight of evening primrose oil, 1 to 5% by weight of polyglyceryl-10 stearate, 1 to 5% by weight of hydrogenated lecithin Weight %, ceramide NP 1-5% by weight, shea butter 1-5% by weight, glycerin 10-20% by weight, tocopherol 0.1-0.5% by weight, hyaluronic acid 0.05-0.2% by weight, hyaluronic acid Disclosed is a cosmetic composition for moisturizing the skin containing a moisturizing complex comprising 0.05 to 0.2% by weight of extract, 0.01 to 0.1% by weight of hydrolyzed collagen, 0.01 to 0.1% by weight of Manuka honey, and 0.5 to 2% by weight of yam root extract has been

Republic of Korea Patent Publication No. 10-1890854 (registered on August 16, 2018) Republic of Korea Patent Publication No. 10-0787312 (registered on December 12, 2007) Republic of Korea Patent Publication No. 10-1909980 (registered on October 15, 2018)

Patent Document 1 as described above discloses a technique for alleviating the underlying skin nerve stimulation that may be induced by exfoliation by a combination of a natural moisturizing factor and an anti-inflammatory complex in the skin, and Patent Document 2 has a moisturizing effect on the skin. It moisturizes the skin whose function as a barrier has been reduced due to lifestyle factors such as excessive washing or bathing, environmental factors such as dry air and pollutants, and intrinsic diseases such as atopic skin or aging skin. Although disclosed with respect to a technology for protection, a technology for alleviating puffiness of the facial region (cheek region and eyelid region) has not been disclosed.

In addition, although the above Patent Document 3 presents a technique capable of continuously maintaining the skin moisturizing effect, the above-described Patent Document 3 also does not disclose a technique for alleviating facial swelling.

It is an object of the present invention to provide a cosmetic composition for moisturizing and relieving swelling of the facial skin that can be maintained as firm and moist skin by alleviating swelling of the face (cheek area and eyelid area) will do

Another object of the present invention is to provide a cosmetic composition for moisturizing and relieving swelling of the skin of the face, which can be quickly absorbed into the skin of the face without stickiness.

In order to achieve the above object, the cosmetic composition for moisturizing and alleviating swelling of the facial skin according to the present invention is characterized in that it contains panthenol, arnica montana flower extract, ceramide NP and mugunghwa bark extract as active ingredients.

In addition, in the cosmetic composition for moisturizing and relieving swelling of the facial skin according to the present invention, the panthenol, arnica montana flower extract, ceramide NP, and Mugunghwa bark extract are contained in an amount of 0.5 to 2% by weight based on the total weight of the cosmetic composition.

In addition, in the cosmetic composition for moisturizing and alleviating swelling of the facial skin according to the present invention, 0.1 to 2.0% by weight of panthenol, 0.0001 to 0.01% by weight of arnica montana flower extract, 0.01 to 1.0% by weight of ceramide NP, Mugunghwa based on the total weight of the cosmetic composition It is characterized in that it contains 0.00001 to 0.002% by weight of the bark extract.

In addition, in the cosmetic composition for moisturizing and alleviating swelling of the facial skin according to the present invention, dipropylene glycol, glycerin, 1,2-hexanediol, butylene glycol, hydrogenated lecithin, cetearyl alcohol, glyceryl stearate Late, sorbitan stearate, xylitol, purslane extract, adenosine, erythritol, fragrance, xylitol glucoside, anhydroxylitol, incarnata fenugreek extract, Angelica root extract, alpha-glucan oligosaccharide, rosehip fruit oil, Edelweiss callus culture extract, Gelidium cartilageneum extract, Euclidean bark extract, Stearic acid, Sugar pumpkin seed extract, Sugar pumpkin extract, Ceramide NS, Phytosphingosine, Copper tripeptide-1, Cholesterol, Ceramide ACE, It is characterized in that it further contains at least one of ceramide AP, palmitoyl pentapeptide-4, oligopeptide-1, dipeptide-2, tripeptide-1, and ceramide IOP.

In addition, in the cosmetic composition for moisturizing and alleviating swelling of the facial skin according to the present invention, the cosmetic composition is a paste, a gel, a cream, a lotion, a powder, a solid soap, a water soap, a shampoo, a rinse, a solution, a suspension, an emulsion, a mineral cosmetic, a powder Perfume, surfactant-containing or surfactant-free cleansing, oil, powder foundation, emulsion foundation, hair dye, wax, softening lotion, nourishing lotion, nourishing cream, massage cream, essence, cleansing cream, cleansing foam, pack, pack It is characterized in that it is used in any one of a base, eye cream, fragrance, ointment, cleansing water, powder, wax foundation, and spray.

As described above, according to the cosmetic composition for moisturizing and alleviating swelling of the skin of the face according to the present invention, it is possible to relieve the swelling of the face (cheeks and eyelids) to maintain firm and moist skin.

1 is a graph of the test result showing the change in moisture content by skin layer (depth 2.5 mm) of the facial part (cheek part) and skin layer (depth 2.5 mm) of the facial part (cheek part),
2 is a graph of the test result showing the moisture content improvement rate for each skin layer (depth 2.5mm) of the facial part (cheek part) as a change in moisture content by skin layer (depth 2.5mm);
3 is a graph of the test result showing the change in the facial (cheek) skin volume index, and the degree of improvement in the facial (cheek) skin volume index;
4 is a graph of test results showing the facial (cheek) skin volume index change trend, and the facial (cheek) skin volume improvement rate;
5 is an Antera 3D (Elevation: Very large) measurement photograph of a test site and a control site according to the present invention.

The above and other objects and novel features of the present invention will become more apparent from the description of the present specification and accompanying drawings.

Edema is also called edema because of the accumulation of excess water. More than 70% of body fluid is present in our body, of which two-thirds is intracellular fluid, and the remaining one-third is extracellular fluid. One-fourth of the extracellular fluid is blood and the other three-quarters is interstitial fluid. When the interstitial fluid increases, the body swells, also called edema. Among them, the swelling of the face deforms the impression and has an unfavorable effect on the aesthetics, so it can be said to be a concern for many people.

In the present invention, the effect on the swelling of the facial part (cheeks and eyelids) was confirmed, the safety of its use was evaluated, and a cosmetic composition for moisturizing and alleviating swelling of the facial skin was prepared.

That is, as a result of testing the sample according to the present invention on 21 subjects for a total of 4 weeks of testing, there may be temporary or individual differences, but the facial area (cheek area) test site using the sample is determined by skin layer after sample use. The moisture content and skin volume decreased to a statistically significant level (p<0.05), and it was confirmed that there was a statistically significant difference (p<0.05) in the moisture content and skin volume for each skin layer even in comparison with the control area. It was judged that it can help relieve swelling of the face (cheek area).

Meanwhile, as used herein, the term "skin moisturizing" refers to maintaining homeostasis of a living body by appropriately controlling moisture loss (water evaporation) of the skin, and "facial part" refers to the user's cheeks and eyelids. means to include

Hereinafter, an embodiment according to the present invention will be described.

The cosmetic composition for moisturizing and relieving swelling of the facial skin according to the present invention contains panthenol, arnica montana flower extract, ceramide NP and mugunghwa bark extract as active ingredients.

On the other hand, the panthenol, arnica montana flower extract, ceramide NP and Mugunghwa bark extract may be contained in an amount of 0.5 to 2% by weight based on the total weight of the cosmetic composition.

The Panthenol has a property of changing into water-soluble vitamin B5 when absorbed into the skin, promotes epithelial cell growth, binds moisture to provide skin radiance and moisturizing effect to dull skin, and blocks moisture evaporation to the skin It strengthens the barrier and affects the regeneration of skin cells, and is used as a skin softener, skin moisturizer, skin conditioning agent, and antistatic agent.

The panthenol is contained in an amount of 0.1 to 2.0% by weight, preferably 0.7% by weight, based on the total weight of the cosmetic composition.

Also, the scientific name of Arnica is Arnica montana L., and it mainly contains sesquiterpene lactone and flavonoids. It was confirmed to have a protective effect. Arnica is a perennial herb of the Asteraceae family that grows wild in the mountainous regions of Germany, including the Alpine Highlands, and in Europe, it was used as a folk remedy for bruises, falls, bruised muscles, breast pain, chronic inflammation, and chronic boils. The flower contains astralin (kaempfrol-3-glycoside), isoquercetin, fatty oil, and the root contains thymohydroquin-one-dimethylether and fumaric acid. On the other hand, arnica oil is prepared by crushing arnica flower or root, immersing it in vegetable oil (soybean oil) and filtering, and as an arnica extract, a water-soluble arnica extract extracted with water, ethanol, and polyhydric alcohols is also used.

The arnica montana flower extract is contained in an amount of 0.0001 to 0.01% by weight, preferably 0.001% by weight, based on the total weight of the cosmetic composition.

In addition, ceramide (Ceramide) acts on the epidermis and the epidermis of the skin, providing continuous moisturizing and skin regeneration effects. That is, the ceramide complex plays a role in improving the skin, such as moisturizing the skin and restoring the skin barrier when applied to the skin. It may include two or more selected from the group consisting of phosphate.

In the present invention, ceramide NP is applied, and this ceramide NP is a synthetic N-acylated sphingolipid component in which saturated or unsaturated fatty acids are bound to phytosphingosine having a D-erythro structure. It is known to give shine, luster, and elasticity to the hair, protect damaged hair or prevent the progression of damage.

The ceramide NP is contained in an amount of 0.001 to 1.0% by weight, preferably 0.1% by weight, based on the total weight of the cosmetic composition.

On the other hand, Mugunghwa (Hibiscus syriacus) is a deciduous shrub of the mallow family, a dicotyledonous plant, distributed in Korea, Singapore, Hong Kong, and Taiwan. The stem bark or root bark is called Mokgunpi, and the outer bark of Mugunghwa is peeled and used as a raw material for paper. It is used as a medicine, and the leaves are called rhizomes, have antipyretic effects, and treat red body and red baekjeokli. In other words, in oriental medicine, the bark of Mugunghwa stops itching by reducing heat and discharging toxins, contains powerful antioxidants that prevent aging by responding to free radicals, protects skin elasticity by preventing UVB damage, and has excellent whitening and anti-inflammatory properties. It is known to maintain the effectiveness and strong moisturizing effect.

The Mugunghwa tree bark extract is, for example, about 1 to 30 times, preferably about 3 to 10 times the weight of the dried sample after removing foreign substances by washing the stem of Mugunghwa with a detergent, drying it in the shade and pulverizing it. An aqueous alcohol solution of 1 to 10, for example, 96% ethanol, extracted using an extraction method such as stirring extraction, reflux cooling extraction, cold extraction, ultrasonic extraction or supercritical extraction at 40 to 110° C. for 1 hour to 10 hours can do.

The Mugunghwa bark extract is contained in an amount of 0.00001 to 0.002% by weight, preferably 0.0002% by weight, based on the total weight of the cosmetic composition.

On the other hand, the panthenol, arnica montana flower extract, ceramide NP, and Mugunghwa bark extract may be sequentially added to purified water and mixed by a mixer.

In addition, the cosmetic composition for moisturizing and reducing swelling of the facial skin according to the present invention is purified water, dipropylene glycol, glycerin, 1,2-hexanediol, butylene glycol, hydrogenated lecithin, cetearyl alcohol, glycerin Lil stearate, sorbitan stearate, xylitol, purslane extract, adenosine, erythritol, flavoring, xylitol glucoside, anhydroxylitol, incarnata fenugreek herb extract, Angelica root extract, alpha-glucan oligosaccharide, rosehip fruit Oil, edelweiss callus culture extract, gelidium cartilageneum extract, cypress bark extract, stearic acid, sugar pumpkin seed extract, sugar pumpkin extract, ceramide NS, phytosphingosine, copper tripeptide-1, cholesterol, ceramide ACE, ceramide AP, palmitoyl pentapeptide-4, oligopeptide-1, dipeptide-2, tripeptide-1, and ceramide IP.

The cosmetic composition for moisturizing and alleviating swelling of the facial skin as described above may be prepared in any conventionally prepared formulation, for example, paste, gel, cream, lotion, powder, solid soap, water soap, shampoo, rinse, solution. , suspension, emulsion, mineral cosmetic, powder perfume, surfactant-containing cleansing or surfactant-free cleansing, oil, powder foundation, emulsion foundation, hair dye, wax, softening lotion, nourishing lotion, nourishing cream, massage cream, essence , cleansing cream, cleansing foam, pack, pack base, eye cream, fragrance, ointment, cleansing water, powder, wax foundation, may be prepared in any one formulation of the spray.

Next, the function of reducing swelling was tested for the product prepared with the cosmetic composition for moisturizing and alleviating swelling of the facial skin according to the present invention. In addition, in the following test, the results of testing the cheek area from the facial area were shown, but the same could be applied to the eyelid area.

The test method for the cosmetic composition (test substance) for moisturizing and alleviating swelling of the facial skin according to the present invention is as follows.

In the test according to the present invention, in order to exclude the effect of natural swelling reduction according to time change, in the case of the cheek area, the test was conducted with random application/no application on the left/right side of the face. The test substance was applied to the test site by the subject. In principle, the number of times of application is based on the usage and dose of the test substance. However, the number of applications and the total amount of application were determined in consideration of the efficacy of the test substance and adverse skin reactions.

On the other hand, the test subject selection criteria are: 1) A person who voluntarily writes and signs a consent form after the principal investigator or a person delegated by the principal investigator has fully explained the matters to be informed to the subject, 2) a grade including skin diseases , a healthy person without chronic physical disease, and 3) a person capable of smooth follow-up during the test period were selected.

The equipment used for the test according to the present invention is as follows.

1) F-ray (Moire)

F-RAY is a skin diagnosis device that can check the height, contours, wrinkles and offs of the face surface by shooting an image with contour lines on the subject using the moire phenomenon, a kind of light phenomenon. Moire refers to an interference fringe in the form of a wave pattern having a larger period when two or more reflecting or transmitting screens having spatial periodicity in white light are superimposed on top of each other. The phenomenon in which periodic patterns overlap and create a pattern larger than the original period is called "Moire interference", and the pattern that occurs at this time is called "Moire pattern". F-ray using this Moire technique improves reproducibility by using a facial fixing device that fixes the forehead and chin in order to accurately compare skin conditions. , 60°), it can be usefully used to compare images taken from various angles. In addition, the special F-ray case and blackout device allow you to shoot images with the same brightness and contrast regardless of lighting, weather, time, and location. A high resolution image that can be checked can be obtained.

2) ANTERA 3DTM (Miravex, Ireland)

Antera 3D® is a high-resolution three-dimensional image measuring device that analyzes the skin condition by imaging the reflected signal when visible light of different frequencies is irradiated to the skin as a light source. Optical methods and mathematical algorithms are used to obtain a three-dimensional image, and through this, data can be extracted from a three-dimensional image of the skin, and skin changes over time can be analyzed by quantifying the degree of skin improvement. The image can measure the depth and width of fine wrinkles, the roughness of the skin, and the number of pores. There are 8 image measurement modes, and in each mode, analysis is possible with subdivided options depending on the analysis filter, and various parameter analysis values can be obtained by designating the desired analysis area.

3) MoistureMeterD Compact (Delfin Technologies, Finland)

MoistureMeter D Compact generates a low-energy high-frequency electromagnetic field to non-invasively measure the Tissue (TDC) of a specific range of tissue, and the tissue dielectric constant is converted into a water ratio in the range of 0-100%. The tissue dielectric constant measured in this way is proportional to the water content of the tissue, and it is the principle that the tissue dielectric constant increases when the water content in the tissue changes due to edema or the like. The MoistureMeter D Compact has an effective depth of 2 to 2.5 mm, and as a stand-alone device, measurement data can be simply obtained with a built-in contact pressure sensor and LCD screen.

The test sequence was performed as follows.

Test subjects are prohibited from using basic products and makeup from 12 hours before any visit, and from one week before the start of the human application test, use of therapeutic agents, cosmetics and quasi-drugs, etc. for the purpose of skin improvement that may affect the evaluation results, Massage was prohibited.

As for the test method, the test subject visits the test start date (week 0), uses the test substance at the designated test site for 4 weeks, and evaluates the swelling relief efficacy. It can be set appropriately by taking this into account, and it was measured by visiting a testing institution 2 to 3 times in total.

In consideration of the subject's natural facial swelling and its reduction, the subject washed his face using the standard face wash provided by the tester and then tapped it lightly with a paper towel to remove moisture, RH) at rest.

On the other hand, to ensure that measurements can be made at the same site during each evaluation, 1) Moisturemeter D: The point where the horizontal line in the alare meets the ipsilateral mid-pupillary line, 2) Antera 3D: The entire nasolabial fold It was partitioned into both cheeks containing

In addition, the evaluation and analysis method were as follows.

1) Evaluation of the effect of reducing the volume of the cheek area using Antera 3D

Measure the skin volume level before, 2 weeks, and 4 weeks after using the sample.

The degree of volume improvement is derived as a % value as follows.

Volume improvement rate (%) =

{(Measured value before sample use-Measured value after sample use)/Measured value before sample use} * 100

2) Evaluation of moisture content improvement effect by skin layer using MoistureMeterD Compact

Measure the moisture content of each skin layer (depth 2.5mm) mechanically before using the sample, after 2 weeks of use, and after 4 weeks of use.

The degree of moisture content improvement for each skin layer is derived as a % value as follows.

Moisture content improvement by skin layer (%) =

{(Measured value before sample use-Measured value after sample use)/Measured value before sample use} * 100

On the other hand, for safety evaluation by a dermatologist, the occurrence of side effects (erythema, edema, scale, itchiness, stinging, burning, stiffness, tingling and other abnormalities) due to the use of the sample was evaluated on every visit day of the subject during the test period.

In addition, the statistical analysis method was applied as follows.

1) Check significance using Minitab 19 (Minitab® 192, Minitab Inc) program.

If the result value is estimated to be normally distributed through the Ryan-Joiner Normality Test, the significance is checked through the parametric statistical method below.

Comparison of pre- and post-result values within the same group: Paired t-test is used to compare values measured before and after the test, and when measurements are repeated three or more times, the significance level p < 0.05 through repeated measure ANOVA Check the significance at the level.

Comparison of result values between two or more different groups: Welch's t-test is used to compare the results between two groups, and the significance level p < 0.05 through one-way ANOVA for comparison of results between groups of three or more. check the significance in

Comparison of results of two or more different groups with repeated measures: Significance is checked at the significance level p < 0.05 through repeated measure ANOVA. The difference in the results between groups is checked through an Analysis of Covariance.

If normality is rejected in the Ryan-Joiner Normality Test, significance is checked through the nonparametric statistical method below.

Comparison of pre- and post-result values within the same group: Wilcoxon signed rank test is used to compare values measured before and after the test.

Comparison of results between two or more groups: Mann-Whitney U test is used to compare results between two groups, and a Kruskal-Wallis test to compare results between groups of 3 or more is significant at the significance level p < 0.05. do.

Comparison of results of two or more different groups repeatedly measured: Check the difference in results between groups at the significance level p < 0.05 through Friedman's test.

According to the above criteria, all data were summarized as mean and standard deviation for continuous variables and frequency and percentage for categorical variables.

The basic information of the subject for testing the test substance of the cosmetic composition for facial skin moisturizing and swelling relief according to the present invention is shown in Table 1.

No gender age No gender age One female 35 12 female 49 2 female 37 13 female 49 3 female 42 14 female 52 4 female 42 15 female 52 5 female 42 16 female 53 6 female 44 17 female 54 7 female 44 18 female 56 8 female 45 19 female 56 9 female 47 20 female 57 10 female 47 21 female 57 11 female 48

The summary information of the subjects applied to Table 1 is shown in Table 2 below.

Table 3 below shows the moisture content measurement results (MoisturemeterDvalue, A.U.) for each skin layer (depth 2.5mm).

No test site contrast area before the exam 2 weeks after the exam 4 weeks after exam before the exam 2 weeks after the exam 4 weeks after exam One 61.40 60.40 59.60 64.20 64.00 64.80 2 43.40 42.20 42.40 41.20 41.40 42.20 3 47.20 44.80 45.40 47.60 47.40 47.80 4 45.20 43.20 42.80 42.00 47.20 43.00 5 53.40 51.40 51.00 47.40 46.80 48.60 6 44.00 44.20 42.60 42.80 42.00 41.80 7 57.00 57.40 52.00 59.20 61.40 59.20 8 45.00 44.00 42.80 47.20 47.00 45.00 9 57.60 56.40 52.20 58.90 58.20 54.40 10 57.40 57.00 56.80 60.00 63.40 62.20 11 53.20 51.60 52.00 52.80 54.60 53.60 12 49.20 43.20 42.80 49.40 49.80 49.80 13 49.80 48.20 45.20 49.20 51.00 48.60 14 48.80 46.00 43.40 44.60 44.40 44.00 15 49.00 47.80 43.80 46.00 47.60 46.00 16 55.40 54.80 51.00 55.00 54.40 52.40 17 46.40 45.40 43.40 45.80 46.40 44.80 18 59.60 57.20 53.00 55.60 56.40 54.80 19 51.20 51.00 48.80 49.60 51.40 50.60 20 53.40 51.00 51.40 53.00 53.40 52.60 21 55.80 53.00 48.40 50.20 50.40 50.20

Table 4 below shows the moisture content (%) normality test, Ryan-Joiner Normality Test for each skin layer (depth 2.5 mm).

Table 5 below shows comparative statistics before and after the moisture content (%) for each skin layer (depth 2.5 mm), the Friedman test.

division parking N estimated median rank sum S P-value
exam
part before the exam 21 51.33 61.0
31.14
< 0.001 test week 2 21 50.27 40.0 test week 4 21 48.80 25.0

Table 6 below shows comparative statistics before and after the moisture content (%) for each skin layer (depth 2.5 mm), and repeated measurement ANOVA.

Table 7 below shows the moisture content (%) statistics for each skin layer (depth 2.5 mm) and post-test.

In Table 7, the means that did not share a letter had a statistically significant (p<0.05) difference.

Table 8 shows the homogeneity statistics of the moisture content (%) measured by skin layer (depth 2.5 mm) before the test, Welch's t-test.

Table 9 below shows the Friedman test, comparative control between groups of measured values of moisture content (%) for each skin layer (depth 2.5 mm).

Table 10 below shows the amount of moisture (%) change (Δ) normality test and Ryan-Joiner Normality Test for each skin layer (depth 2.5 mm) at each time point.

division
Average Standard Deviation N RJ P-value black exam
part 2 Weekly change (△) 1.53 1.360 21 0.923 <0.010 rejection of normality 4 Parking change (△) 3.41 2.002 21 0.966 >0.100 normal distribution contrast
part 2 Weekly change (△) -0.82 1.495 21 0.925 <0.010 rejection of normality 4 Parking change (△) 0.24 1.450 21 0.961 0.099 normal distribution

Table 11 below shows the statistical analysis between the groups, the Mann-Whitney U test, for the amount of moisture (%) change (Δ) for each skin layer (depth 2.5 mm) at each time point.

Table 12 below shows the statistical analysis of the amount of moisture (%) between the groups, Welch's t-test, for each skin layer (depth 2.5 mm) at each time point.

Table 13 below shows the moisture content improvement degree (Local tissue water, MoisturemeterDvalue, %) for each skin layer (depth 2.5 mm).

division Measures(%) improvement rate p-value
exam
part before the exam 51.54 -
< 0.001
2 weeks after the exam 50.01 ^*** 2.97% 4 weeks after exam 48.13 ^*** 6.61%
contrast
part before the exam 50.54 -
0.005 2 weeks after the exam 51.36 ^** -1.62% 4 weeks after exam 50.30 0.47%

Significant probability : *p<0.05, **p<0.01, ***p<0.001

As a result of confirming the change in the amount of moisture for each skin layer (depth 2.5mm) of the test site during the test period for the cosmetic composition for moisturizing and alleviating swelling of the face according to the present invention, a statistically significant level (p<0.05) at the test site from 2 weeks after the test ), it was confirmed that the moisture content decreased by skin layer (depth 2.5mm). In addition, in comparison with the non-applied control site, it was confirmed that the decrease in the amount of change in moisture content by skin layer (depth 2.5 mm) was larger in the test site with a statistically significant difference (p<0.05) at each time point.

1 is a graph of test results showing the change in moisture content by skin layer (depth 2.5mm) of the facial part (cheek part), and the degree of moisture content improvement by skin layer (depth 2.5mm) of the facial part (cheek part). Area) It is a graph of the test result showing the moisture content improvement rate for each skin layer (depth 2.5mm) of the facial (cheek area) skin layer (depth 2.5mm) as the change in moisture content by skin layer (depth 2.5mm).

Table 14 below shows the skin volume Antera 3D measurement results (Elevation: Very large, mm ³ ).

No test site contrast area before the exam 2 weeks after the exam 4 weeks after exam before the exam 2 weeks after the exam 4 weeks after exam One 16.29 10.93 8.87 30.81 35.14 33.15 2 37.48 31.93 21.12 49.76 47.44 46.17 3 56.03 50.15 46.46 21.33 28.72 27.82 4 24.23 24.66 18.37 39.63 40.20 48.77 5 43.10 41.89 35.49 46.15 44.89 44.17 6 80.40 65.93 60.03 37.19 49.27 67.97 7 59.60 53.26 50.20 49.61 52.42 57.32 8 64.47 60.64 57.04 38.64 34.34 34.02 9 75.91 59.98 63.15 69.84 78.29 78.61 10 27.65 26.92 27.55 48.68 49.64 52.50 11 36.47 35.54 34.32 42.35 44.09 50.05 12 105.00 107.80 56.11 56.44 54.08 61.51 13 74.92 63.55 53.16 31.19 38.14 56.95 14 41.78 40.81 31.52 51.16 51.80 53.40 15 35.22 26.99 14.53 23.87 43.27 21.80 16 51.06 33.13 37.13 43.00 43.86 42.68 17 27.47 22.82 20.04 20.01 34.41 26.78 18 107.10 91.64 84.55 54.96 56.47 62.89 19 19.08 18.67 13.36 37.63 33.57 34.46 20 94.09 95.00 86.68 72.92 45.95 44.92 21 43.75 42.17 40.41 50.07 52.57 53.45

Table 15 below shows the skin volume (㎣) normality test, the Ryan-Joiner Normality Test.

Table 16 below shows comparison statistics before and after skin volume (mm 3 ), and repeated measures ANOVA.

division factor DF Adj.SS Adj.MS F-value P-value test site week 2 1628 814 17080 <0.001

Table 17 below shows comparative statistics before and after skin volume (mm 3 ), the Friedman test.

Table 18 below shows skin volume (mm 3 ) statistics and post hoc tests.

Means that do not share letters have statistically significant (p<0.05) differences.

Table 19 below shows the skin volume (mm 3 ) measured value homogeneity statistic, Welch's t-test, before the test.

Table 20 below shows the comparison and control between the skin volume (mm 3 ) measured value groups, the Friedman test.

Table 21 below shows the amount of change in skin volume (㎣) by time point (Δ) normality test, Ryan-Joiner Normality Test.

division
Average Standard Deviation N RJ P-value black exam
part 2 Weekly change (△) 5.56 6.16 21 0.954 0.062 normal distribution 4 Parking change (△) 12.43 10.59 21 0.881 <0.010 rejection of normality contrast
part 2 Weekly change (△) -2.06 9.028 21 0.914 <0.010 rejection of normality 4 Parking change (△) -4.01 11.41 21 0.914 <0.010 rejection of normality

Table 22 below shows the amount of change in skin volume (㎣) at each time point (Δ) statistical analysis between groups, the Mann-Whitney U test.

Table 23 below shows the degree of improvement in skin volume (mm 3 ).

Significant probability : *p<005, **p<001, ***p<0001

As a result of confirming the change in skin volume at the test site during the test period, it was confirmed that the skin volume decreased to a statistically significant level (p<0.05) at the test site after 2 weeks of the test. In addition, in comparison with the non-applied control site, it was confirmed that the degree of change in skin volume reduction at each time point was larger in the test site with a statistically significant difference (p<0.05).

3 is a graph of the test result showing the degree of improvement of the facial (cheek) skin volume index as a change in the facial (cheek) skin volume index, and FIG. 4 is a change in the facial (cheek) skin volume index. Area) It is a graph of the test result showing the skin volume improvement rate.

5 is an Antera 3D (Elevation: Very large) measurement photograph of a test site and a control site according to the present invention.

On the other hand, as shown in Table 24 below, no special abnormal symptoms occurred during the test period.

The test results as described above are as follows.

1) As shown in Fig. 2, the reduction rate of moisture content by skin layer (depth 2.5mm) of the cheek area was confirmed to be 2.97% and -1.62% for the test site and the control area after 2 weeks of the test, respectively, and 6.61% after 4 weeks of the test. % and 0.47%, which is a result of a decrease in moisture content by skin layer (depth 2.5mm) to a statistically significant level (p<0.05) compared to before the test from 2 weeks after the test at the test site. In addition, in comparison with the non-applied control site, it was confirmed that the degree of decrease in the amount of moisture in each skin layer of the test site was a statistically significant difference (p<0.05), which was large.

2) As shown in FIG. 4, the volume reduction rate of the cheek area was confirmed to be 10.41% and -4.73% of the test site and -4.73%, respectively, after 2 weeks of the test, and 23.28% and -9.19% after 4 weeks of the test, respectively. This is the result of a decrease in the volume of the cheek area at the test site from 2 weeks after the test to a statistically significant level (p<0.05) compared to before the test. In addition, it was confirmed that the degree of decrease in the volume of the cheek area of the test site was large with a statistically significant difference (p<0.05) in comparison with the uncoated control site.

The invention made by the present inventors has been described in detail according to the above embodiments, but the present invention is not limited to the above embodiments and various modifications can be made without departing from the gist of the present invention.

By using the cosmetic composition for moisturizing and alleviating swelling of the facial skin according to the present invention, it is possible to relieve swelling of the facial region (cheek region and eyelid region), thereby maintaining firm and moist skin.

Claims (5)

Contains panthenol, arnica montana flower extract, ceramide NP and mugunghwa bark extract as active ingredients,
Based on the total weight of the cosmetic composition, 0.1 to 2.0% by weight of the panthenol, 0.0001 to 0.01% by weight of arnica montana flower extract, 0.01 to 1.0% by weight of ceramide NP and 0.00001 to 0.002% by weight of Mugunghwa bark extract Moisturizing facial skin, characterized in that it contains and a cosmetic composition for alleviating swelling. delete delete In claim 1,
Dipropylene glycol, glycerin, 1,2-hexanediol, butylene glycol, hydrogenated lecithin, cetearyl alcohol, glyceryl stearate, sorbitan stearate, xylitol, purslane extract, adenosine, erythritol, Fragrance, xylyl glucoside, anhydroxylitol, incarnata fenugreek extract, Angelica root extract, alpha-glucan oligosaccharide, rosehip fruit oil, edelweiss callus culture extract, gelidium cartilageum extract, cypress bark Extract, Stearic Acid, Sugar Pumpkin Seed Extract, Sugar Pumpkin Extract, Ceramide NS, Phytosphingosine, Copper Tripeptide-1, Cholesterol, Ceramide ACE, Ceramide AP, Palmitoyl Pentapeptide-4, Oligopeptide-1, Dy A cosmetic composition for moisturizing and relieving swelling of the facial skin, characterized in that it further contains at least one of peptide-2, tripeptide-1, and ceramide IO. In claim 1,
The cosmetic composition is a paste, gel, cream, lotion, powder, solid soap, water soap, shampoo, rinse, solution, suspension, emulsion, mineral cosmetic, powder perfume, surfactant-containing cleansing or surfactant-free cleansing, oil, Powder foundation, emulsion foundation, hair dye, wax, flexible lotion, nourishing lotion, nourishing cream, massage cream, essence, cleansing cream, cleansing foam, pack, pack base, eye cream, fragrance, ointment, cleansing water, powder, wax foundation , A cosmetic composition for moisturizing and relieving swelling of the facial skin, characterized in that it is used in any one of the sprays.

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