CN109481328A - A kind of acne-eliminating cosmetic additive and its cosmetics and preparation method - Google Patents
A kind of acne-eliminating cosmetic additive and its cosmetics and preparation method Download PDFInfo
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- CN109481328A CN109481328A CN201811577556.1A CN201811577556A CN109481328A CN 109481328 A CN109481328 A CN 109481328A CN 201811577556 A CN201811577556 A CN 201811577556A CN 109481328 A CN109481328 A CN 109481328A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a kind of acne-eliminating cosmetic additive and its cosmetics and preparation methods, it is intended to provide a kind of mild non-stimulated, have a good improvement to small pox, especially to fourth stage scar have some improvement effect, restore the acne-eliminating cosmetic additive and its cosmetics of skin barrier function；Its technical solution are as follows: the acne-eliminating cosmetic additive is nonanedioyl amine MEA, and the additive amount in cosmetics is the 2.0-15.0% of cosmetics quality, belongs to cosmetic technical field.
Description
Technical field
The present invention relates to a kind of additives, specifically, being to be related to acne-eliminating cosmetic additive, the invention further relates to contain to dispel
The cosmetics of pox cosmetic additive and the preparation method of the cosmetics, belong to cosmetic technical field.
Background technique
Small pox scientific name is acne, is the chronic inflammation disease of pilosebaceous follicle, pathogenic factors and hypersteatosis,
The factors such as pilosebaceous duct blocking, bacterium infection and inflammatory reaction are closely related.Specifically, as androgen spy in human body
It is not the level raising rapidly of testosterone, sebaceous glands is promoted to develop and generate a large amount of sebums.The angling of pilosebaceous duct simultaneously
Exception causes catheter blockage, and dyssebacia forms horn plug, that is, micro mist thorn.Multiple-microorganism especially acne third in hair follicle
Acidfast bacilli mass propagation, the lipase that propionibacterium acnes generate decompose sebum and generate free fatty acid, while chemotactic inflammatory cell
And medium, it finally induces and aggravates inflammatory reaction.
By the stage point of small pox development, small pox is generally divided into 4 stages, and the first stage: acne start, silent not oxidized
Be Whiteheads；Being oxidized to black is blackhead.Second stage: inflamed papules, small pox evolve into one from acne
A red packet to swell not only but also ache grain of rice size protruded, can also sometimes see the purulence head that there is yellow on top.Third rank
Section: tumour, tubercle, the appearance of small pox by be the very deep very pain of a soya bean size red induration, multiple can merge.After scleroma
Phase can become to touch up the soft tumour of capsule, and the inside is all fester.Fourth stage: scar, one is the hyperplasia that formation protrudes
Property scar；One is form sunk atrophic scar.
The cosmetics of anti-acne emerge one after another now, such as: hospital often uses product for resolving poxes, azelaic acid, but its irritation compares
Greatly, generally in hospital's Special use；Also have based on salicylic acid, but salicylic acid irritation is big, regulation limitation without departing from
2.0%, while being easy to be precipitated, it is not easy the application of cosmetics, certainly, the appearance of the technology of liposome has carried out salicylic acid package,
But because of the problem of there is also free salicylic acids after package, a technical problem is also become to product thickening.Limit application.
Also there are many products for surrounding Pi Aoning (polyquaternium -73) anti-acne in the market, then the proud peaceful light-exposed easy colour fading inactivation of skin, because
This also limits application.Certainly there are very much many anti-acne substances and a product, but a technological deficiency, summarize that there are two major reasons.The
One, effect is not significant enough；Second, using upper existing defects.
Summary of the invention
In view of the above-mentioned problems, having good improvement to small pox the first purpose of the invention is to provide a kind of mild non-stimulated
Effect, especially to fourth stage scar have some improvement effect, restore skin barrier function acne-eliminating cosmetic additive.
A second object of the present invention is to provide a kind of cosmetics containing above-mentioned acne-eliminating cosmetic additive.
Third object of the present invention is to provide the preparation methods of the cosmetics containing above-mentioned acne-eliminating cosmetic additive.
To solve first technical problem, first technical solution provided by the invention is such that
A kind of acne-eliminating cosmetic additive, the acne-eliminating cosmetic additive is nonanedioyl amine MEA, in cosmetics
Additive amount be cosmetics quality 2.0-15.0%.
Further, a kind of above-mentioned acne-eliminating cosmetic additive, the acne-eliminating cosmetic additive further include pH tune
Agent is saved, the pH adjusting agent accounts for the 0.1-1.0% of cosmetics gross mass.
Further, above-mentioned a kind of acne-eliminating cosmetic additive, the acne-eliminating cosmetic additive includes nonanedioyl
Amine MEA and pH adjusting agent, the nonanedioyl amine MEA account for the 6.0-12.0% of cosmetics gross mass, and the pH adjusting agent accounts for
The 0.5-0.8% of cosmetics gross mass.
Further, above-mentioned a kind of acne-eliminating cosmetic additive, the pH adjusting agent are arginine, aminomethyl third
The one or more combinations of alcohol, potassium hydroxide, sodium hydroxide.
Second technical solution provided by the invention is the cosmetics containing above-mentioned acne-eliminating cosmetic additive, the change
Cosmetic is gel, pH 6.0-8.0.
Further, the cosmetics of above-mentioned acne-eliminating cosmetic additive, the gel is by following mass percentages
Component be made: moisturizer 5-18%, nonanedioyl amine MEA2.0-15.0%, thickener 0.46-1.1%, solubilizer 0.2-
0.6%, pH adjusting agent 0.5-0.8%, preservative 0.1-0.5%, chelating agent 0.01-0.15%, surplus are deionized water.
Further, the cosmetics of above-mentioned acne-eliminating cosmetic additive each component and its account in the moisturizer
The percentage of gel quality are as follows: dipropylene glycol 3.0-10.0%, butanediol 2.0-8.0%.
Further, the cosmetics of above-mentioned acne-eliminating cosmetic additive, the thickener are each component and its account for
The percentage of gel quality are as follows: polyacrylate cross-linked polymer -6 0.05-0.2%, carbomer 0.40-0.80%, xanthan gum
0.01-0.1%.
Further, the cosmetics of above-mentioned acne-eliminating cosmetic additive, the solubilizer are rilanit special；It is described
PH adjusting agent be one of arginine, aminomethyl propanol, potassium hydroxide, sodium hydroxide or any combination；Described is anti-
One of one or more combinations of rotten agent methyl hydroxybenzoate, pentanediol, hexylene glycol, pungent glycol or any combination；Described；Institute
The chelating agent stated is EDETATE SODIUM.
Third technical solution provided by the invention is the preparation method of above-mentioned cosmetics, and this method successively includes following
Step:
(1) deionized water, chelating agent, polyalcohol, thickener are added in main phase pot, are stirred and heated to 80-85 DEG C of dissolution
After completely, 5-10min is kept the temperature；
(2) nonanedioyl amine MEA is added to main phase pot, mixing speed 20-50r/min stirs 10-15min, dissolved
Entirely, after mixing evenly, it then cools, opens pumped vacuum systems.
(3) it is then cooled to 50-55 DEG C, adds pH adjusting agent, mixing speed 10-15r/min stirs 5-10min；It opens
Open pumped vacuum systems, it is ensured that the transparent bubble-free of product.
(4) it is cooled to 38-40 DEG C, adds preservative, solubilizer opens pumped vacuum systems, it is ensured that the transparent bubble-free of product,
Mixing speed is 5.0-10r/min, stirs 5-10min.
Testing product, controls pH value 6.0-8.0, viscosity 40-80pa.s, appearance be it is light yellow to yellow transparent gel,
Detection is qualified, is discharged with the filter-cloth filtering of 100 mesh.
Compared with prior art, technical solution provided by the invention has following technological merit:
(1) technical solution provided by the invention is using nonanedioyl amine MEA (100% azelaic acid amide monoamides) as main
Anti-acne ingredient, slight distinctive odor is non-stimulated, and sensitization, not water-soluble, and in skin care and its additional amount is total to account for skin care item
The 2.0-15.0% of weight, pH value, on emulsification system and thickened systems without influence, are suitable for oiliness and seborrheica skin in 6-8
The nursing of skin.It can also be used for treatment acne, include acne caused by acne, friction caused by medicine cause property acne, cosmetics etc..This
Outside, Exfoliating Scrub treatment, rosacea treatment (erythema and acne rosacea) are also used to.
(2) blemish clearing gel stability provided by the invention is good, no precipitation, no layering, no thickening failure phenomenon, easy to use
And it is mild non-stimulated.
(3) provided by the invention to the acne of small pox, inflamed papules, tumour, the effective anti-acne reparation of tubercle, to small pox the 4th
Stage scar has some improvement effect, restores skin barrier function.
(4) dissolution and moisturizer are used as using dipropylene glycol and butanediol in technical solution provided by the invention, not only mentioned
The performance of keeping humidity of high product, and be conducive to nonanedioyl amine MEA and preferably play acne-removing, improvement restores skin
Barrier function, while formula solubility property is also improved, make gel products more penetrating.
Specific embodiment
Claim of the invention is described in further detail combined with specific embodiments below.
Embodiment 1
A kind of acne-eliminating cosmetic additive provided by the invention, the acne-eliminating cosmetic additive are nonanedioyl amine MEA,
In terms of cosmetics gross mass 100%, additive amount in cosmetics is the 2.0-15.0% of cosmetics quality, such as 2%,
5%, 8%, 10%, 12%, 15%.
Embodiment 2
A kind of acne-eliminating cosmetic additive provided by the invention, the acne-eliminating cosmetic additive are nonanedioyl amine MEA
And pH adjusting agent, in terms of cosmetics gross mass 100%, additive amount of the nonanedioyl amine MEA in cosmetics is cosmetics quality
2.0-15.0%, such as 2%, 5%, 8%, 10%, 12%, 15%, pH adjusting agent accounts for the 0.5-0.8% of cosmetics gross mass,
To adjust cosmetics pH value as 6-8, the pH adjusting agent can be arginine or aminomethyl propanol or potassium hydroxide or hydrogen-oxygen
Change the combination of sodium or arginine and aminomethyl propanol.
Embodiment 3
A kind of blemish clearing gel provided by the invention, every 100g are made of component: dipropylene glycol 3.0g, butanediol 3.0g, nonyl
Diamides MEA2.0g, polyacrylate cross-linked polymer -6 0.05g, carbomer 0.40g, xanthan gum 0.01g, rilanit special
0.2g, arginine 0.2g, aminomethyl propanol 0.2g, methyl hydroxybenzoate 0.1g, EDETATE SODIUM 0.15g, surplus are deionized water, and pH is
6.0-8.0。
Embodiment 4
A kind of blemish clearing gel provided by the invention, is made of the component of following mass percentages: dipropylene glycol 8.0g, fourth
Glycol 10.0g, nonanedioyl amine MEA 15.0g, polyacrylate cross-linked polymer -6 0.05g, carbomer 0.40g, xanthan gum
0.01g, rilanit special 0.6g, sodium hydroxide 0.10g, hexylene glycol 0.2g, pungent glycol 0.3g, EDETATE SODIUM 0.01g, surplus are
Deionized water.
Embodiment 5
A kind of blemish clearing gel provided by the invention, is made of the component of following mass percentages: dipropylene glycol 8.0g, fourth
Glycol 5.0g, nonanedioyl amine MEA12g, polyacrylate cross-linked polymer -6 0.2g, carbomer 0.8g, xanthan gum 0.1g, hydrogen
Change castor oil 0.3g, aminomethyl propanol 0.6g, pentanediol 0.4g, EDETATE SODIUM 0.05g, surplus is deionized water.
Embodiment 6
A kind of blemish clearing gel provided by the invention, is made of the component of following mass percentages: dipropylene glycol 5g, fourth two
Alcohol 5g, nonanedioyl amine MEA 8g, polyacrylate cross-linked polymer -6 0.1g, carbomer 0.4g, xanthan gum 0.1g hydrogenate castor
Sesame oil 0.3g, arginine 0.45g, methyl hydroxybenzoate 0.3g, EDETATE SODIUM 0.05g, surplus are deionized water.
The preparation method of any one group of blemish clearing gel successively includes the following steps: in embodiment 3 to 6
(1) deionized water, chelating agent, moisturizer, thickener are added in main phase pot, are stirred and heated to 80-85 DEG C of dissolution
After completely, 5-10min is kept the temperature；
(2) nonanedioyl amine MEA is added to main phase pot, mixing speed 20-50r/min stirs 10-15min, dissolved
Entirely, after mixing evenly, it then cools, opens pumped vacuum systems.
(3) it is then cooled to 50-55 DEG C, adds pH adjusting agent, mixing speed 10-15r/min stirs 5-10min；It opens
Open pumped vacuum systems, it is ensured that the transparent bubble-free of product.
(4) it is cooled to 38-40 DEG C, adds preservative, solubilizer opens pumped vacuum systems, it is ensured that the transparent bubble-free of product,
Mixing speed is 5.0-10r/min, stirs 5-10min.
Testing product, controls pH value 6.0-8.0, viscosity 40-80pa.s, appearance be it is light yellow to yellow transparent gel,
Detection is qualified, is discharged with the filter-cloth filtering of 100 mesh.
In order to prove the effect of acne-removing composition provided by the invention, acne-removing composition provided by the invention is given below
Testing inspection data.
1. acne-removing test method and test result；
(1) test method is sketched: propionibacterium acnes bacteriostatic test (rubbing method)
A. rubbing method is for evaluating acne-removing composition.Preparation containing propionibacterium acnes (ATCC11827) double-layer plate (under
Layer is the culture medium of 10~15ml, and upper layer is culture medium of the 5ml containing propionibacterium acnes), plate bacteria containing amount is 104~105CFU/
Plate accurately weighs 0.5g acne-removing composition sample, is uniformly applied on plate containing bacterium with aseptic cotton carrier after plate is cooling, in
It is cultivated under 36 ± 1 DEG C of anaerobic conditions 24 hours, then observes bacterium colony growing state in plate.
(2) result judgement standard:
Table 1-1 acne-removing evaluation criterion
(3) test result:
Table 1-2 sample acne-removing test result
To exclude influence of other preservatives to fungistatic effect, preservative is not added for the sample for carrying out acne-removing test.
Test result shows that desquamation compositions have good inhibition propionibacterium acnes (ATCC11827) effect, therefore has good
Acne-removing.
2. eye irritation tests (CAMVA test) method and test result
(1) test method is sketched:
Chorioallantoic membrane blood vessel tests the side (Chorioallantoic membrane vascular assay, CAMVA)
Method, to the potential eye irritation of the evaluation of effect of blood vessel, takes 14 days instar chicken embryos, tested material directly contacts CAM by observation tested material
Small region, CAM Vascular change is observed after exposure 30 minutes, such as bleeding or hyperemia (telangiectasis), blood vessel disappear
(ghost blood vessel), so that 50 parts of fertilized eggs the tested material concentration of these damages is occurred is considered as toxic endpoints.CAMVA test needs
It measures 10 and 50 parts of positive reaction dosage achieved occurs for examination chicken embryo.
(2) result judgement standard:
Table 1-3 CAMVA test scores standard
(3) test result:
Table 1-4 acne-removing composition CAMVA experimental test result
| Serial number | Sample ID | Vascular effect scoring | Irritation explanation |
| 1 | 3 product of embodiment | 0 | It is reactionless |
| 2 | 4 product of embodiment | 0 | It is reactionless |
| 3 | 5 product of embodiment | 0 | It is reactionless |
| 4 | 6 product of embodiment | 0 | It is reactionless |
Test result shows, the equal < 1.0 of average integral of the CAMVA test of acne-removing composition, therefore acne-removing composition is not
It can cause potential irritation or allergic reaction to human body.
The above content is specific preferred embodiment is combined, further detailed description of the invention, cannot recognize
Fixed specific implementation of the invention is only limited to these instructions.Without departing from the inventive concept of the premise, it can also make several
Simple deduction or replace all shall be regarded as belonging to present invention scope of patent protection determined by the appended claims.
Claims (10)
1. a kind of acne-eliminating cosmetic additive, which is characterized in that the acne-eliminating cosmetic additive is nonanedioyl amine MEA,
Additive amount in cosmetics is the 2.0-15.0% of cosmetics quality.
2. a kind of acne-eliminating cosmetic additive according to claim 1, which is characterized in that the acne-eliminating cosmetic addition
Agent further includes pH adjusting agent, and the pH adjusting agent accounts for the 0.1-1.0% of cosmetics gross mass.
3. a kind of acne-eliminating cosmetic additive according to claim 1, which is characterized in that the acne-eliminating cosmetic addition
Agent includes nonanedioyl amine MEA and pH adjusting agent, and the nonanedioyl amine MEA accounts for the 6.0-12.0% of cosmetics gross mass, described
PH adjusting agent account for the 0.5-0.8% of cosmetics gross mass.
4. a kind of acne-eliminating cosmetic additive according to claim 1, which is characterized in that the pH adjusting agent is smart ammonia
The one or more combinations of acid, aminomethyl propanol, potassium hydroxide, sodium hydroxide.
5. a kind of cosmetics containing acne-eliminating cosmetic additive described in claim 1, which is characterized in that the cosmetics are
Gel, pH 6.0-8.0.
6. the cosmetics of acne-eliminating cosmetic additive according to claim 3, which is characterized in that the gel is by following
The component of mass percentage is made: moisturizer 5-18%, nonanedioyl amine MEA2.0-15.0%, thickener 0.46-1.1%, increases
Solvent 0.2-0.6%, pH adjusting agent 0.5-0.8%, preservative 0.1-0.5%, chelating agent 0.01-0.15%, surplus be go from
Sub- water.
7. the cosmetics of acne-eliminating cosmetic additive according to claim 3, which is characterized in that each in the moisturizer
A component and its percentage for accounting for gel quality are as follows: dipropylene glycol 3.0-10.0%, butanediol 2.0-8.0%.
8. the cosmetics of acne-eliminating cosmetic additive according to claim 3, which is characterized in that the thickener is each
A component and its percentage for accounting for gel quality are as follows: polyacrylate cross-linked polymer -6 0.05-0.2%, carbomer 0.40-
0.80%, xanthan gum 0.01-0.1%.
9. the cosmetics of acne-eliminating cosmetic additive according to claim 3, which is characterized in that the solubilizer is hydrogen
Change castor oil；The pH adjusting agent is for one of arginine, aminomethyl propanol, potassium hydroxide, sodium hydroxide or arbitrarily
Combination；One of one or more combinations of the preservative methyl hydroxybenzoate, pentanediol, hexylene glycol, pungent glycol are any
Combination；The chelating agent is EDETATE SODIUM.
10. the method for preparing the cosmetics of acne-eliminating cosmetic additive as claimed in claim 6, which is characterized in that successively include
Following step:
(1) deionized water, chelating agent, polyalcohol, thickener are added in main phase pot, it is complete is stirred and heated to 80-85 DEG C of dissolution
Afterwards, 5-10min is kept the temperature；
(2) nonanedioyl amine MEA being added to main phase pot, mixing speed 20-50r/min stirs 10-15min, and dissolution is complete,
After mixing evenly, it then cools, opens pumped vacuum systems.
(3) it is then cooled to 50-55 DEG C, adds pH adjusting agent, mixing speed 10-15r/min stirs 5-10min；It opens and takes out
Vacuum system, it is ensured that the transparent bubble-free of product.
(4) it is cooled to 38-40 DEG C, adds preservative, solubilizer opens pumped vacuum systems, it is ensured that the transparent bubble-free of product, stirring
Speed is 5.0-10r/min, stirs 5-10min.
(5) testing product, controls pH value 6.0-8.0, viscosity 40-80pa.s, and appearance is light yellow to yellow transparent gel, inspection
It is qualified to survey, and is discharged with the filter-cloth filtering of 100 mesh.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811577556.1A CN109481328A (en) | 2018-12-20 | 2018-12-20 | A kind of acne-eliminating cosmetic additive and its cosmetics and preparation method |
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| CN201811577556.1A CN109481328A (en) | 2018-12-20 | 2018-12-20 | A kind of acne-eliminating cosmetic additive and its cosmetics and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318065A (en) * | 2021-05-07 | 2021-08-31 | 西安润玉医疗科技有限公司 | Composite acid and microecological conditioning composition and preparation process thereof |
| IT202300005049A1 (en) * | 2023-03-17 | 2024-09-17 | Vida S R L | TWO-PHASE COMPOSITION FOR TOPICAL USE |
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| US20120225106A1 (en) * | 2011-03-01 | 2012-09-06 | Isp Investments Inc. | Personal care compositions with suspended metal oxides |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20120225106A1 (en) * | 2011-03-01 | 2012-09-06 | Isp Investments Inc. | Personal care compositions with suspended metal oxides |
| KR20180096948A (en) * | 2017-02-22 | 2018-08-30 | 한윤섭 | A cosmetic composition for promoting hair growth and preventing hair loss |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318065A (en) * | 2021-05-07 | 2021-08-31 | 西安润玉医疗科技有限公司 | Composite acid and microecological conditioning composition and preparation process thereof |
| CN113318065B (en) * | 2021-05-07 | 2023-01-03 | 西安润玉医疗科技有限公司 | Composite acid and microecological conditioning composition and preparation process thereof |
| IT202300005049A1 (en) * | 2023-03-17 | 2024-09-17 | Vida S R L | TWO-PHASE COMPOSITION FOR TOPICAL USE |
| EP4431160A1 (en) * | 2023-03-17 | 2024-09-18 | Vida S.R.L. | Biphasic composition for topical use |
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