KR20100010647A - Patch for inhibiting hair loss and enhancing hair growth - Google Patents

Abstract

PURPOSE: A patch formulation for preventing hair loss or promoting hair growth is provided to prevent scalp irritation and conveniently use the formulation. CONSTITUTION: A patch formulation for preventing hair loss or promoting hair growth contains 2,4-diamino-6-pyrrolidino-pyridine-3-oxide compound, 2,4,-diamino-6-piperidino-pyrimidine-3-oxide compound or natural plant material extract as an active ingredient. The patch formulation is a hydrogel sheet in which hydrogel is applied on a support. The patch formulation is attached boundary site between scalp and forehead. The natural plant material includes thujae Semen, sophorae Radix, ginseng, zingiberis Rhizoma crudus, swertia japonica, angelicae gigantis Radix, glycyrrhizae radix, capsicum tincture, paeoniae Radix, polygoni multiflori Radix, black soybean, black sesame, green tea, camellia japonica, rehmanniae Radix Preparata, mori Radicis Cortex, chrysanthemi sibirici Herba, cnidii Rhizoma, angelicae dahuricae Radix, nepetae Spica, carthami Flos, lithospermi radix, scutellariae Radix, and lycii Fructus.

Description

Patch For Inhibiting Hair Loss and Enhancing Hair Growth}

The present invention relates to a patch for preventing hair loss or hair growth promoting which is very easy to use while showing an excellent hair loss preventing or hair growth promoting effect.

In modern society that emphasizes beauty, many people, regardless of age or gender, use hair dyes and perm agents to satisfy their desire for expressing individuality. However, some of the sensitive scalp may cause irritation and inflammation such as itching or stinging of the scalp by chemical treatment such as dyeing and perming.

Such irritation and inflammation are leading to environmental hair loss. In addition, hair loss can also be caused by genetic causes, and many men or women suffer from severe mental pain. Therefore, various studies for preventing hair loss and promoting hair growth have been actively conducted.

However, in a very busy life, it is very cumbersome for modern people to use hair loss prevention products or hair growth products. Specifically, conventional formulations have a problem that they are very cumbersome due to the solubilized form of the external preparation bar, when flowing on the scalp, or need to massage the scalp. In addition, there are inconveniences such as having to use it twice a day for several months every long term.

Therefore, there is a growing need for development of a formulation that is easy to use while providing excellent hair loss prevention or hair growth promoting effect.

The present invention aims to solve the technical problem that has been requested from the past. Specifically, by remarkably improving the problems found in conventional formulations that have been used for the prevention and treatment of hair loss, it is possible to provide a patch agent that is very easy to use while exhibiting excellent hair loss prevention or hair growth promoting effect.

Hair loss prevention or hair growth promoting patch according to the present invention for achieving this purpose 2,4-diamino-6-pyrrolidino-pyrimidine-3-oxide (2,4-diamino-6-pyrrolidino- pyrimidine-3-oxide) compound, 2,4-diamino-6-piperidino-pyrimidine-3-oxide compound and natural plant extracts It comprises one or more selected from the group consisting of as an active ingredient.

Hair loss prevention or hair growth promoting patch according to the present invention promotes hair growth by strengthening the hair root, while exhibiting a very good hair loss prevention effect, does not cause irritation to the scalp and is very easy to use and can be used conveniently have.

The inventors of the present application, the compound 2,4-diamino-6-pyrrolidino-pyrimidine-3-oxide of the general formula (1) At least one selected from the group consisting of 2,4-diamino-6-piperidino-pyrimidine-3-oxide compounds and extracts of natural plant materials When the active ingredient is applied to a mouse from which hair has been removed, vasodilation function is induced to induce the hair cycle from the resting period to the growth phase, thereby promoting hair growth, preventing hair loss, and promoting hair growth. It was confirmed that there is an effect to prevent or treat alopecia.

(1)

(One)

(2)

(2)

Among the active ingredients, the compound of Formula 1 is a known heterocyclic material, and is a pyrrolidinyl diaminopyrimidine oxide compound, and the compound of Formula 2 is minoxidil, and these may exhibit hair loss prevention or hair growth promotion with natural plant material. .

The natural plant material is white porcelain, ginseng, ginseng, ginger, medicinal herbs, donkey, licorice, red pepper tink, peony, sesuo, black beans, black sesame, baekbokyeong, green tea, camellia, sujiji, baekbaekpi, gujeolcho, cheongung, baekji, hyeonggae, It may be one or more selected from the group consisting of safflower, purple, golden, wolfberry, gardenia, turmeric, astragalus, sweet ginseng, nasturtium, schisandra chinensis and wormwood, and may be white porcelain, ginseng, or a combination thereof.

The natural plant material is not particularly limited unless it is a particular problem in terms of safety of the composition, its action may not be a problem. However, the natural plant ingredients may be formulated for hair loss prevention, hair growth promotion, and hair root strengthening function, and may be prepared through a commercially available raw material in a known manner.

In one preferred embodiment, the active ingredient comprises an extract of the compound of Formula 1 and natural plant material, or includes an extract of the compound of Formula 2 and natural plant material, or the compound of Formula 1 and Formula 2 It may include a compound and extracts of natural plant material.

The content of the compound of Formula 1 is not particularly limited, but may be included in an amount of 0.01 to 20% by weight, preferably 0.1 to 5% by weight, based on the whole of the active ingredient, wherein the content of the compound of Formula 1 is less than 0.01% by weight In case of poor efficacy and effect, and the content of the compound of Formula 1 exceeds 20% by weight there is a problem in stabilizing the formulation.

In addition, the total content of the compound of Formula 1, the compound of Formula 2, and the natural plant material as the active ingredient is not particularly limited, but may be included in 0.005 to 20% by weight based on the entire patch, the content of the active ingredient If the content is less than 0.005% by weight, the efficacy and effect are weak, and if it exceeds 20% by weight, there is a problem in stabilizing the formulation.

Other components than the active ingredients may be appropriately selected and blended by those skilled in the art according to the purpose of use and the like without difficulty.

The present invention, as defined above, relates to a patch for preventing hair loss or promoting hair growth comprising the active ingredient.

The patch has no irritation to the scalp and has a superior feeling of use, and the detachable patch can exert a desired hair loss prevention effect. The method of use is very simple and can be conveniently used. It is a form of a novel hair loss prevention or hair growth promoting agent that has not been found.

Conventionally, preparations in the form of external preparations for preventing hair loss or promoting hair growth have been used. When a large amount of coating is applied to achieve a desired degree of hair loss prevention or hair growth promoting effect, problems such as flowing down cause hair loss. It was very difficult to apply efficiently directly to the trigger site and did not have an effective degree of hair loss prevention or hair growth promoting effect. However, the patch according to the present invention is a solution to the problems of the prior art.

In one preferred embodiment, the patch may be in the form of a hydrogel sheet coated with a hydrogel (hydrogel) to collect the active ingredient for preventing hair loss or promoting hair growth.

The hydrogel sheet is attached to the skin to induce the absorption of high concentration of the active ingredient is a formulation, unlike the external agent, there is no stickiness, excellent skin adhesion, but can feel the moisture when worn.

The support may be a known support, and is not particularly limited. For example, the support may be a nonwoven fabric made of felt by combining fibers in a parallel or inverse direction without going through a woven fabric process, and then combining the fibers with a synthetic resin adhesive. The nonwoven fabric may be suitable as a support for the hydrogel sheet because the fibers are entangled, there is no vertical and horizontal orientation, and the cut edges do not loosen.

Where the patch is attached is not particularly limited as long as it is a site for inducing hair loss prevention or hair growth promoting effect, for example, it may be attached to the boundary region of the scalp and forehead. According to the following Examples and Experimental Examples, it can be seen that when the patch is attached to the boundary area of the scalp and forehead can exhibit the most excellent hair loss prevention effect.

The patch is not particularly limited so long as it is of sufficient size to provide a dosage of the active ingredient having the desired surface area to be covered, but for example in an area of about 1 to 200 cm ² , preferably about 10 to 180 cm ² . Can be done.

The time required to deliver an effective amount of the active ingredient exhibiting the desired effect in the patch does not exceed about 48 hours and may not exceed about 24 hours. In addition, the time for which the formulation is maintained is at least about 30 minutes, about 1 hour, and can be applied several times daily for the time required to be effective.

Hereinafter, although an Example and a test example are given and this invention is demonstrated more concretely, this invention is not limited only to these examples.

[Comparative Example 1 and Examples 1 to 3]

To Comparative Example 1 and Examples 1 to 3 according to the composition of Table 1 were prepared.

Test Example 1 Hair Growth Effect Test

The hair growth effects of the active ingredients included in the patch according to the invention were tested.

An active ingredient consisting of the compositions of Examples 1 to 3 and Comparative Example 1 was selected daily by removing seven pieces of hair from the back of the seven-week-old mouse (C57BL / 6), selecting clean skin on the back, and selecting seven animals for each material group. Was applied for 21 days at 150 μl per individual mouse group. As a negative control, a solvent consisting of water / ethanol / 1,3-butylene glycol (5/3/2) was used, and Comparative Examples 1 and 1 to 3 were 0.5% by weight of the active ingredient, It was used by dissolving in a solvent composed of water / ethanol / 1,3-butylene glycol (5/3/2).

After 23 days, photographs of the degree of growth of the mouse hair were taken, and the weight of the newly grown hair was measured and compared with the negative control, and the results are shown in Table 2 and FIG. 1.

As can be seen from Table 2 and FIG. 1, when the active ingredient according to Examples 1 to 3 was applied to the mouse, hair higher than the group to which the general solution (water / ethanol / 1,3-butylene glycol) was applied When the weight average value is shown, it can be confirmed that there is an excellent hair growth promoting effect.

 Preparation Example 1 Preparation of Patch

A patch was prepared according to Table 3 below.

The method of manufacturing a patch is as follows. Polyacrylic acid was neutralized using a neutralizing agent, and the agar polymer was heated to 100 ° C. to boil and stirred. After cooling to 70 ° C., an oil component, a softening agent, was added, and an anti-hair loss and hair growth active ingredient was blended at 50 ° C. or lower. The raw material blended by the extrusion method was sent to the coater and loaded into the nonwoven fabric. When the contents were loaded, the resultant was dried while passing through the chamber, and the formed nonwoven hydrogel was aged at 40 ° C. for 2-3 days and then cut to prepare a hydrogel patch.

[Comparative Examples 2 to 5 and Example 4]

To prepare a patch including the active ingredient of Example 1 in the composition of Table 1, and then to test for hair loss prevention by attachment sites, the attachment sites are shown in Table 4 and FIG.

 Test Example 2 Hair Loss Prevention Effect Test

Thirty subjects with initial hair loss were tested for anti-hair loss for 12 weeks. According to Comparative Examples 2 to 6 and Example 4, once every day for 12 weeks at the attachment site, after 12 weeks, the hair loss was collected and counted again when the hair was washed, and the results are shown in Table 5. It was.

As can be seen from Table 5, when the patch prepared with the active ingredient of Example 1 is treated at the boundary attachment site of the forehead and the scalp as in Example 4, it was confirmed that the number of the falling off hair significantly reduced It was. In the case of Comparative Example 2, the patch was not attached to the experimental group attached to the hair, and thus the experimental results could not be obtained.

Those skilled in the art to which the present invention pertains will be able to perform various applications and modifications within the scope of the present invention based on the above contents.

1 is a photograph showing the degree of hair growth of the mouse treated with the active ingredient according to the present invention;

FIG. 2 is a view showing a portion to which a patch is attached according to Examples and Comparative Examples of a hair loss prevention experiment. FIG.

Claims (6)

2,4-diamino-6-pyrrolidino-pyrimidine-3-oxide (2,4-diamino-6-pyrrolidino-pyrimidine-3-oxide) compound, 2,4-diamino-6-piperidino Hair loss prevention or hair growth promotion patch comprising at least one selected from the group consisting of pyrimidine-3-oxide (2,4-diamino-6piperidino-pyrimidine-3-oxide) compounds and natural plant extracts as an active ingredient My. The method of claim 1, The patch is a patch for preventing hair loss or hair growth, characterized in that in the form of a hydrogel coated with a hydrogel (hydrogel) collecting the active ingredient on a support. The method of claim 1, The patch is a patch for preventing hair loss or hair growth, characterized in that attached to the boundary of the scalp and forehead. The method of claim 1, The patch agent for preventing hair loss or promoting hair growth, characterized in that for preventing or treating alopecia by promoting hair growth. The method of claim 1, The natural plant material is white porcelain, ginseng, ginseng, ginger, medicinal herbs, Angelica, licorice, red pepper tink, peony, sesuo, black beans, black sesame, baekbokyeong, green tea, camellia, sujiji, baekbaekpi, gujeolcho, cheongung, baekji, hyeonggae, A patch for preventing hair loss or promoting hair growth, characterized in that at least one selected from the group consisting of safflower, purple, golden, wolfberry, gardenia, turmeric, astragalus, dansam, nasturtium, Schisandra chinensis and wormwood. The method of claim 1, The 2,4-diamino-6-pyrrolidino-pyrimidine-3-oxide (2,4-diamino-6-pyrrolidino-pyrimidine-3-oxide) compound is 0.01 to 20% by weight based on the whole active ingredient Hair loss prevention or hair growth promoting patch comprising a.

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