JP2006290832A - Skin lotion - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin lotion excellent in the prevention and improving effects of acne symptom and also excellent in skin roughness-preventing and improving effects, and moisturizing effect. <P>SOLUTION: This skin lotion is provided by using 1 kind or ≥2 kinds selected from the extracts of a turmeric (Curcuma longa Koen), carrot (Daucus carota L.) and mugwort (Artemisia princeps Pamp) with bittern and shell flower (Alpinia speciosa (Wendl) K. Schum) extract simultaneously. As the carrot extract, the compressed and squeezed liquid of root of Shima (island) carrot produced in Okinawa, etc., is preferable. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an external preparation for skin which is excellent in the effect of preventing and improving acne symptoms, and also excellent in the effect of preventing and improving rough skin and the effect of moisturizing. More specifically, the present invention relates to a skin external preparation comprising bittern and moon peach extract as essential components and further using one or more selected from turmeric extract, carrot extract and mugwort extract.

  Acne is an inflammatory disease of the follicular sebaceous gland system that occurs in areas where there are many sebaceous glands such as the face and back. In general, acne onset factors include endocrine factors, bacterial factors, keratinization disorder factors, and the like. The endocrine factor means that the function of the sebaceous glands becomes active due to the influence of male hormones, and sebum secretion increases and acne is easily formed. Bacterial factor means that the triglyceride in sebum is hydrolyzed by lipase produced by acne bacteria that grew by sebum nutrition, and the generated free fatty acid stimulates the hair follicle wall to cause hyperkeratosis, Or acne bacteria are inflamed by hyaluronidase or protease. Furthermore, the keratinization disorder factor is that the keratinocytes become difficult to detach due to increased keratinization of the epidermis tissue of the hair funnel, so that the hair follicles become occluded, and the internal reservoir, which is a mixture of keratinocytes, sebum, etc., smoothly It means a state where it is no longer discharged.

  As an external agent for acne treatment, lotions, emulsions, creams, etc. formulated with active ingredients such as sebum suppression / absorption component, keratin softening / peeling component, antibacterial / bactericidal component, anti-inflammatory component, etc. Many ointments are used. For example, those containing a bactericidal agent such as salicylic acid, antibiotics such as erythromycin, tetracycline, lindamycin, sulfur, camphor and sulfa, antibacterial agents and keratin removers are used. However, general antibiotics, antibacterial agents, etc., may be used to kill even useful microorganisms on the skin or damage the skin around acne due to repeated application. If the amount used is reduced, sufficient acne improvement effect cannot be obtained.

  Further, the stratum corneum peeling agent and sebum suppressing / absorbing component may cause dryness and roughness of the skin, which is not cosmetically preferable. When a moisturizer is added to suppress these skin damages, there is a problem that the feeling of use deteriorates such as stickiness.

  Moreover, about utilization of the ghetto extract in the skin external preparation field | area, the bath agent (patent document 1) which uses as an active ingredient the strip which squeezed the raw leaf of Tyling ghetto which is a kind of ghetto and pulverized and dried, or a ghetto leaf or A hair-growth agent or hair growth agent containing an extract from a stem or a pressed solution and containing medicinal cosmetics (Patent Document 2) effective for improving acne and rough skin, and ghetto extract (mainly essential oil) as an active ingredient (Patent Document 3) and the like have been disclosed, and recently, various effects of ghetto extract such as fibroblast proliferation promoting action, collagen production promoting action, collagenase inhibiting action of ghetto leaf extract have been reported (Non-Patent Document 1). Is attracting attention.

  Attempts have long been made to incorporate bittern into a topical skin preparation, and recently, a hair nourishing agent containing bittern as an active ingredient (Patent Document 4), cosmetic skin containing magnesium ions and calcium ions in a specific ratio. Invention relating to specific effects such as protective ability, barrier function recovery effect (Patent Document 5), skin moisturizing and protective agent used in combination with urea, glycerin and alum (Patent Document 6), moisturizing and skin combined with fish skin elastin A skin external preparation excellent in protective effect (Patent Document 7), a composition having a skin condition improving action in combination with phytoncide and chitosan (Patent Document 8) and the like are disclosed.

JP 11-349471 A JP 2000-191493 A JP 2000-355525 A Japanese Patent Laid-Open No. 11-1414 JP 2002-47119 A JP 2000-109421 A JP 2001-39826 A JP 2001-131018 A Fragrance Journal, 5, 86-91 (2001)

  The object of the present invention is to provide an external preparation for skin that is excellent in preventing and improving acne symptoms, as well as in preventing and improving rough skin, and excellent in moisturizing effect.

  As a result of various studies to solve the above problems, bittern and moon peach extract are essential ingredients, and further, one or more selected from turmeric extract, carrot extract, mugwort extract are used in combination with a skin external preparation As a result, it was found that a skin external preparation excellent in the prevention / amelioration effect of acne symptoms, skin rough prevention / improvement effect, and moisturizing effect was obtained, and the present invention was completed.

  According to the present invention, it was possible to obtain a skin external preparation excellent in acne symptom prevention / amelioration effect and excellent in skin roughening prevention / improvement effect and moisturizing effect.

  The bittern used in the present invention is a liquid obtained by crystallization of sodium chloride from seawater or a dried product thereof. The composition of bittern varies depending on the salt production method (ion exchange membrane method, solar method, salt field method or evaporation method), temperature at the time of salt crystallization, salt concentration and pressure at the time of salt crystallization, and other conditions. Table 1 shows an example of the composition of bittern with different salt production methods (Non-patent Document 1 “Inorganic Industry Overview”, Baifukan Co., Ltd., 1995, p38-39). In addition, the unit of the numerical value of Table 1 is g / 100g. In addition, regarding the bittern by the ion exchange membrane method, it varies depending on the characteristics of the ion exchange membrane.

  The bittern used in the present invention is a solution obtained by crystallization of salt from seawater, a dried product thereof, or an artificially mixed mineral. The composition of bittern varies depending on the production area, salt production method (ion exchange membrane method, sun method, salt field method or evaporation method), temperature at the time of salt crystallization, salt concentration and pressure at the time of salt crystallization, and other conditions. Nigari, which is prepared from seawater collected in the waters around Amami Islands or Minami Daito Island, is free from contamination by organic phosphate compounds and other substances contained in seawater and has a high stratum corneum improvement effect. It is done.

  The amount of bittern in the present invention is 0.001 to 5% by weight, preferably 0.005 to 1% by weight, based on the total amount of the external preparation for skin.

Alpinia zerumbet (Alpinia speciosa (Wendl.) K. Schum.) Is the ginger (Zingiberaceae) family Hanamyouga (Alpinia) plants in the genus also called alias Sannin, antioxidant effect on the essential oil component obtained from leaves, antiseptic, deodorant It is known to have action and insect repellent action, and it has been used for a long time in Okinawa. Many reports have been made on the analysis of the essential oil components of ghetto and how to use the essential oil.

  In the present invention, extracts obtained from leaves, stems, flowers, roots and whole plants of ghetto can be selected and used, respectively, but from the point of antibacterial effect against acne bacteria, It is preferable to use an extract.

  The compounding quantity of the ghetto extract in this invention is 0.01 to 1 weight% with respect to the skin external preparation whole quantity, Preferably it is 0.05 to 1 weight%.

Turmeric ( Curcuma longa Koen.) Used in the present invention is a perennial plant belonging to the family Zingiberaceae , and each part of leaves, stems, flowers, fruits, roots, etc. and whole grass can be used. Is preferred. Further, dried turmeric rhizomes are a kind of herbal medicine called “turmeric”, and such herbal medicine can also be used.

The carrot ( Daucus carota L.) used in the present invention is a perennial herb belonging to the Umbelliferae family, and many cultivated species are known. In the present invention, it is preferable to use Shimanin, which is cultivated in the Amami Islands and Okinawa Islands, from the viewpoint of its moisturizing and rough skin improving effects. Carrots can be used in various parts such as leaves, stems, roots, and whole plants, but the roots are preferably used. Moreover, as a carrot extract, it is preferable to use what was crushed and squeezed while the root part was raw.

Mugwort ( Artemisia princeps Pamp.) Used in the present invention is a perennial plant belonging to the Compositae family, and each part of leaves, stems, flowers, fruits, roots, etc. and whole plants can be used, but leaves are used. Is preferred. Also, dried mugwort leaves are a kind of herbal medicine called “mugwort”, and such herbal medicine can also be used.

  In the present invention, one or more selected from turmeric extract, carrot extract, and mugwort extract are used. The blending amount of these extracts can exert an effect with a smaller amount of blending than when blended individually. Specifically, the total amount of the extract is 0.01 to 3% by weight, preferably 0.05 to 1% by weight, based on the total amount of the external preparation for skin.

  Subsequently, the plant extract used in the present invention is one obtained by extracting the above-mentioned plants as they are or after pulverization, or extracted as they are or after being pulverized with a solvent.

  When extracting a plant extract, the above-mentioned plants may be subjected to extraction as they are, but considering the extraction efficiency, it is preferable to perform extraction after processing such as shredding, drying, and pulverization. Extraction is performed by immersing in an extraction solvent. In order to increase the extraction efficiency, stirring may be performed, or homogenization may be performed in an extraction solvent. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but is suitably about 4 hours to 14 days.

  Extraction solvents include water, lower alcohols such as methanol, ethanol, propanol, and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol, and glycerin, and ethers such as ethyl ether and propyl ether. , Polar organic solvents such as esters such as ethyl acetate and butyl acetate, and ketones such as acetone and ethyl methyl ketone can be used, and one or more of these are selected and used. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used.

  The above-mentioned extract of the above plant can be contained in the skin external preparation according to the present invention as it is, but the concentrated and dried solid can be dissolved again in water or a polar solvent, or their skin physiological function improving action can be obtained. You may use after performing the refinement | purification processes, such as decoloring, deodorizing, and desalting, in the range which is not impaired, or performing the fractionation process by column chromatography. For storage, it can be freeze-dried after purification and dissolved in a solvent before use. It can also be used by encapsulating in vesicles such as liposomes or microcapsules.

  In the present invention, it is selected from anti-inflammatory agents, keratin softeners, and antibacterial agents in combination with one or more selected from the above bittern, ghetto extract, turmeric extract, carrot extract, mugwort extract. One or more drugs can be used in combination. By using these drugs in combination with bittern, ghetto extract, etc., it becomes possible to reduce the amount of the drug.

  Anti-inflammatory agents include cortisone, hydrocortisone, prednisolone, methylprednisolone, dexamethasone, betamethasone, triamcinolone, triamcinolone acetonide, fluocinolone acetonide, fluocinonide, beclomethasone and their phosphates, propionate, acetate, succinic acid Steroidal anti-inflammatory agents such as salts, salicylic acid and aspirin, salicylamide, etenzamide, salicylic acid derivatives such as methyl salicylate, indoleacetic acid derivatives such as indomethacin and sulindac, pyrazolidinedione derivatives such as phenylbutazone and oxyphenbutazone, Anthranilic acid derivatives such as mefenamic acid and flufenamic acid, propionic acid derivatives such as ibuprofen, ketoprofen, naproxen, diclofenac, fenbufe Non-steroidal anti-inflammatory drugs such as phenylacetic acid derivatives such as benzothiazine derivatives such as piroxicam, salts and derivatives such as glycyrrhizic acid and dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid and stearyl glycyrrhetinate, glycyrrhetinyl stearate, 3-succinyl Salts and derivatives such as disodium oxyglycyrrhetinate, azulene derivatives such as guaiazulene, ethyl guaiazulene sulfonate, sodium guaiazulene sulfonate, camazulene, derivatives such as allantoin, aloin, aloe emodin, shikonin and isobutyl shikonin, acetyl shikonin, isovaleryl shikonin , Ginsenoside Ra1, ginsenoside Ra2, ginsenoside Rb1, etc., and 20-glucoginosenoside R Examples include ginsenoside derivatives such as f, paeoniflorin, peonol, and peonol derivatives such as peonoside and peonolide.

In the present invention, as an anti-inflammatory agent, an extract from a herbal medicine used as an anti-inflammatory agent such as shikon ( Lithospermi Radix ), ginseng ( Ginseng Radix ), kudin ( Sophorae Radix ), licorice ( Glycyrrhizae Radix ) can also be used. .

  The content of these anti-inflammatory agents is 0.001 to 5% by weight, preferably 0.01 to 2% by weight, based on the total amount of the external preparation for skin, in order to exhibit a sufficient acne prevention / amelioration effect.

  Examples of the keratin softener include glycolic acid, glycolate, citric acid, citrate, lactic acid, lactate, urea, sulfur, salicylic acid, and salicylate. Of these, lactic acid, lactate, urea, and salicylic acid are preferably used from the viewpoint of low irritation to the skin and pre-use examples, and one or more of these can be blended. The blending amount of these keratin softeners is 0.01 to 1 in the case of glycolic acid, glycolate, citric acid, citrate, lactic acid, lactate with respect to the total amount of the external preparation for skin because of its effectiveness. In the case of weight% and urea, the blending amount is preferably about 0.5 to 10% by weight, and in the case of sulfur, salicylic acid and salicylate, the amount is preferably about 0.01 to 1% by weight.

  The antibacterial agent is not particularly limited as long as it has a function of suppressing the growth of acne bacteria and is suitable as a component of the external preparation for skin in terms of safety and the like. Specifically, components used for antibacterial purposes, such as agaric extract, hinokitiol, triclosan, trichlorocarbanilide, chlorhexidine hydrochloride, chlorhexidine glucosane salt, halocarban, chlorophenesin, benzethonium chloride, chloride Mention may be made of benzalkonium chloride, lysozyme chloride, alkyldiaminoethylglycine hydrochloride, isopropylmethylphenol, benzoic acid, photosensitizer 201, thymol, hexachlorophene, berberine, thioxolone and their derivatives.

  These antibacterial agents can be blended in the skin external preparation of the present invention alone or in combination of two or more as required. The content of the antibacterial agent in the cosmetic is 0.001 to 5% by weight, preferably 0.01 to 2% by weight, based on the total amount of the external preparation for skin, in order to exhibit a sufficient acne prevention / amelioration effect.

  The external preparation for skin according to the present invention can be provided in various dosage forms such as lotions, emulsions, gels, creams, ointments, powders, granules and the like. In addition, skin cosmetics such as lotion, milky lotion, cream, beauty essence, packs, foundation cosmetics such as makeup base lotion and makeup base cream, foundations for each dosage form such as emulsion, oily, solid, etc. It can also be provided as makeup cosmetics such as color and cheek color, skin cleansing agents such as cleansing creams, cleansing lotions, cleansing foams, facial soaps and body shampoos.

  The external preparation for skin according to the present invention includes general components such as oil components, surfactants, moisturizers, pigments, ultraviolet absorbers, antioxidants, fragrances, antibacterial and antifungal agents in addition to the above essential components. Bioactive ingredients such as pharmaceutical and cosmetic raw materials, skin cell activators, and whitening agents can also be included.

  Further, the features of the present invention will be described in detail by way of examples. First, the manufacturing example of the bittern used in each Example and each plant extract is shown.

[Production Example 1] Amami Islands Nigari Brine was prepared from seawater collected in the waters around Amami Islands using a polyamide composite reverse osmosis membrane. The resulting brine was heated at 110 ° C. to separate it into bittern and salt, thereby obtaining Tokaranigari.

[Manufacturing Example 2] Nigori Daito Island Nigali Brine was prepared from seawater collected in the sea area around Minami Daito Island using a polyamide composite reverse osmosis membrane. The obtained brackish water was heated at 113 ° C. to separate into bittern and salt, thereby obtaining Minami Daitojima bittern.

[Preparation Examples 3 to 5]
200 g of each plant shown in Table 2 was dried and pulverized, extracted by stirring in 2 liters of 50% by volume ethanol aqueous solution for 7 days at room temperature, filtered to collect the filtrate, concentrated under reduced pressure using a rotary evaporator, Each plant extract was obtained by freeze-drying.

[Production Example 6] Carrot extract The collected root of the carrot is washed with water, pulverized as it is with a processor, and then filtered. The filtrate was dispersed in an equal volume of glycerin to obtain a carrot extract.

  Then, the Example which mix | blended the said preparation example is shown.

[Examples 1 to 5, Comparative Examples 1 to 4]
With the composition shown in Table 3 or Table 4, all ingredients were mixed uniformly to obtain a cosmetic. Acne care effect, rough skin improvement effect, and moisturizing effect were evaluated using the obtained cosmetics.

(Evaluation methods)
Examples or comparative examples were blindly used as a group of 20 women with mixed skin who suffered from acne from 15 to 40 years old and rough skin and dryness. As a method of use, the face was thoroughly washed with a face wash, and then each cosmetic was applied to the entire face twice a day for 4 weeks. The skin before and after use was photographed and compared to evaluate the acne care effect and the rough skin improvement effect, and the moisturizing effect was evaluated by interviewing the dry state of the skin before and after use.

(Evaluation criteria) Acne care effects The improvement status of acne symptoms was evaluated in four stages: "Improved", "Slightly improved", "No change", and "Deteriorated", and Table 5 shows the number of panelists that obtained each evaluation. Indicated.

(Evaluation criteria) Rough skin improvement effect The improvement status of rough skin symptoms was evaluated in four stages: "Improved", "Slightly improved", "No change", and "Deteriorated". Table 6 shows the number of panelists that obtained each evaluation. It was shown to.

(Evaluation criteria) Moisturizing effect The skin dryness is evaluated in two stages, “moist”, “no change”, and “smooth” based on the pre-use condition, and the number of panelists obtained each evaluation. Table 7 shows the results.

  As shown in Tables 5 to 7, in the use groups of Examples 1 to 5 of the present invention, there were no panelists in which each symptom was deteriorated, and acne symptom, improvement of rough skin symptom and dry skin resolving tendency were recognized. On the other hand, in the comparative example in which one kind selected from ghetto extract and bittern, turmeric extract, mugwort extract, and carrot extract was blended in double the amount of the example, an improvement tendency was observed for each symptom. As a result, the number of improved panelists was smaller than that of the embodiment.

[Example 6] Facial cleansing foam
(1) Myristic acid 23.86 (% by weight)
(2) Palmitic acid 3.28
(3) Stearic acid 8.33
(4) Concentrated glycerin 16.00
(5) Lipophilic glyceryl monostearate 3.00
(6) Potassium hydroxide 7.59
(7) Purified water 18.00
(8) 1,3-butylene glycol 3.00
(9) Carboxymethylcellulose sodium 0.03
(10) Palm oil fatty acid amidopropyl betaine solution 3.00
(11) Purified water 12.96
(12) Production Example 1 0.30
(13) Production Example 3 0.30
(14) Production Example 4 0.10
(15) Production Example 5 0.10
(16) Production Example 6 0.10
(17) Fragrance 0.05
Production method: The oil phase components (1) to (5) are mixed and dissolved by heating to 80 ° C. On the other hand, the aqueous phase components (6) and (7) are mixed and dissolved by heating to 80 ° C. The oil phase component is gradually added to the water phase component to neutralize and then mixed, and (8) to (11) heated to 75 ° C. are added, and cooled to 50 ° C. at (12) to (12) Add 17) and cool further while mixing.

[Example 7] Cleansing Massage Gel
(1) Purified water 11.24 (wt%)
(2) Concentrated glycerin 14.40
(3) Sucrose fatty acid ester 5.00
(4) Polyoxyethylene glyceryl isostearate 2.00
(5) 1,3-butylene glycol 3.00
(6) Methyl paraoxybenzoate 0.50
(7) Squalane 32.05
(8) Glyceryl tri-2-ethylhexanoate 18.55
(9) Neopentyl glycol dicaprate 9.28
(10) Stearic acid 1.00
(11) Refined jojoba oil 1.00
(12) Hydrogenated soybean phospholipid 1.00
(13) Production Example 2 0.30
(14) Production Example 3 0.30
(15) Production Example 4 0.10
(16) Production Example 5 0.10
(17) Production Example 6 0.10
(18) Perfume 0.08
Production method: The oil phase components (7) to (12) are mixed and dissolved by heating to 70 ° C. On the other hand, the aqueous phase components (1) to (6) are mixed and dissolved by heating to 70 ° C. The oil phase component is gradually added to this aqueous phase component and pre-emulsified, and then uniformly emulsified with a homomixer, cooled and further added with (13) to (18) at 50 ° C. while mixing. Cooling.

[Example 8] Pack
(1) Purified water 68.07 (% by weight)
(2) Concentrated glycerin 5.00
(3) Polyethylene glycol (average molecular weight 1540) 3.00
(4) Methyl paraoxybenzoate 0.02
(5) Polyvinyl alcohol 12.90
(6) Silicic anhydride 0.06
(7) Ethanol 10.00
(8) Production Example 1 0.30
(9) Production Example 3 0.30
(10) Production Example 4 0.10
(11) Production Example 5 0.10
(12) Production Example 6 0.10
(13) Fragrance 0.05
Production method: Components (2) to (13) are sequentially mixed and dissolved in (1).

[Example 9] Lotion
(1) Purified water 83.19 (wt%)
(2) Polyoxyethylene (50) hydrogenated castor oil 0.05
(3) 1,3-butylene glycol 7.00
(4) Salicylic acid 0.05
(5) Ethanol 4.50
(6) Diglycerin 2.50
(7) Sodium citrate 0.23
(8) Citric acid 0.03
(9) Honey 0.20
(10) Methyl paraoxybenzoate 0.20
(11) Allantoin 0.10
(12) Production Example 2 1.00
(13) Production Example 3 0.50
(14) Production Example 4 0.10
(15) Production Example 5 0.10
(16) Production Example 6 0.10
(17) Maltitol 0.10
(18) Fragrance 0.05
Production method: Components (2) to (18) are sequentially mixed and dissolved in (1).

[Example 10] Cosmetic liquid
(1) Purified water 68.36 (wt%)
(2) Polyoxyethylene (50) hydrogenated castor oil 0.05
(3) Polyethylene glycol 1.40
(4) Rutin glycoside 0.05
(5) Maltitol 0.20
(6) Ethanol 7.00
(7) Methyl paraoxybenzoate 0.10
(8) 1,3-butylene glycol 7.00
(9) Dipotassium glycyrrhizinate 0.10
(10) Carboxyvinyl polymer (1 wt% aqueous solution) 10.00
(11) Xanthan gum (2% by weight aqueous solution) 5.00
(12) Production Example 1 0.50
(13) Production Example 3 0.05
(14) Production Example 4 0.05
(15) Production Example 5 0.01
(16) Production Example 6 0.01
(17) Perfume 0.02
(18) Sodium hydroxide (10% by weight aqueous solution) 0.10
Production method: Components (2) to (17) are sequentially added to (1) and dissolved, and then neutralized with (18).

Claims (4)

An external preparation for skin containing one or more selected from turmeric extract, carrot extract, mugwort extract, bittern and moon peach extract. A skin external preparation for acne containing one or more selected from turmeric extract, carrot extract, mugwort extract, bittern and moon peach extract. A skin external preparation for preventing and improving rough skin, comprising one or more selected from turmeric extract, carrot extract, mugwort extract, bittern and moon peach extract. A skin external preparation for moisturizing containing one or more selected from turmeric extract, carrot extract, mugwort extract, bittern and moon peach extract.