JP3447667B2 - External preparation for skin - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to the use of a plurality of plant extracts in combination, and one or two species selected from the group consisting of collagen and elastin, and their solubilized products, hydrolysates and modified products. Combining the above,
The present invention relates to a skin external preparation capable of easily adapting to the skin and exhibiting a high skin moisturizing effect, a beautiful skin effect and a rough skin improving effect, and a method for skin care characterized by using the skin external preparation in combination.

[0002]

2. Description of the Related Art Conventionally, extracts of various kinds of plants such as medicinal plants have been used for external preparations for skin (Fragrance Journal, Extra edition No. 1, 1979,
The same magazine, Extra Edition 6, No. 6, 1986). In recent years, with the increasing tendency toward nature and plant protection due to animal welfare, there is an increasing tendency to seek active ingredients in plant extracts.

However, although plant extracts have various actions, their actions are generally not so strong in general, and when an external preparation for skin contains an amount of the plant extract which produces the expected action effect. However, undesired coloring or odor was sometimes observed, or the formulation stability was sometimes lowered. Attempts have been made to enhance the action effect by using a plurality of plant extracts in combination, but various factors are involved in the physiological functions of the skin in a complicated manner. It is difficult to improve the skin condition sufficiently.

[0004]

Therefore, in the present invention, by sufficiently improving the physiological function of the skin, it is possible to exert a high skin moisturizing effect, a beautiful skin effect and a rough skin improving effect, and to be compatible with the skin. The aim was to obtain an external preparation for skin which is excellent in formulation stability and safety.

[0005]

[Means for Solving the Problems] As a result of various studies to solve the above problems, as a result of combining an extraction mixture of a specific plant with one or more selected from a specific plant group,
Further, it was found that good results can be obtained by the combined use of one or more selected from the group consisting of collagen and elastin, and their solubilized products, hydrolysates and modified products. The invention was completed.

The use of a solubilized product of collagen and elastin or a hydrolyzate as an external preparation for skin has been studied for a long time in anticipation of a skin moisturizing effect, a rough skin improving effect, an antiaging effect and the like. However, since these are difficult to be percutaneously absorbed, the obtained effects are limited, and it is necessary to strengthen quality control or to add a large amount of antibacterial and antifungal agents in order to maintain the stability of the preparation. This time, by using a combination of plant extracts in the present invention,
It was possible to solve the above-mentioned problems in the use of collagen and elastin as an external preparation for skin.

That is, the external preparation for skin according to the present invention comprises:
(A) and (B), (C) and (D), (E)
(F) and (G) and (H): (A) Chamomile (Matricaria chamomilla L.), Wiki
Ryou (Foeniculum vulgare Miller), Hop (Humulus
 lupulus L.), Achillea millefolium (Achillea mill
efolium L.), Melissa (Melissa officinalis L.) and
Mistletoe (Viscum coloratum Nakai var.lutescens 
Miyabe et Kudo orViscum album L. var.lutescens Ma
kino) extraction mixture; (B) Horse chestnut (Aesculus turbinata Blume), Seiyo
Uchinoki (Aesculus hippocastanum L.), carrot
(Daucus carota L.), Mannenrou (Rosmarinus off
icinalis L.), Daffodil ((Calendula officinal
is L.), calendula (Calendula arvensis L.), Yag
Rumagiku (Centaurea cyanus L.), horsetail (Equisetum
 arvense L.), a plant belonging to the genus Eucalyptus (Eucalyp
tus spp.), plants belonging to the genus Aloe (Aloe spp.), Ma
Lumello (Cydonia oblonga Mill.), Cucumber (Cucumis
 sativus L.), coltsfoot (Tussilago farfara 
L.), Below Aoi (Althaea officinalis L.), Oh
Plants belonging to the genus Epimedium (Hypericum spp.), salvi
A (Salvia officinalis L.) and its variants (Salvia of
ficinalis var.tenuior), Hamamelis (Hamamelis vi
rginiana L.), witch hazel (Hamamelis japonica Sieb.
et Zucc.),Thymus vulgaris
L.), Tormentilla (Potentilla tormentilla),
Elephant (Glycyrrhiza uralensis Fisher,Glycyrrhiza 
glabra L. and its variants,Glycyrrhiza echinataL.,Gly
cyrrhiza glandulifera Reg. Et Herd.), Belonging to the genus Lily
A plant (Lilium spp.), parsley (Petroselinum cris
pum (Mill.) Nym. Ex A.W.Hill.), Belongs to the genus Linden
Plant (Tilia spp.), plants belonging to the genus Birch (Betu
la spp.), beech (Fagus crenata Blume), Inubuna
(Fagus japonica Maxim.), Ginkgo (Ginkgo biloba
 L.), Kizuta (Hedera tobleri Nakai), Seiuki
Shreds (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis L.) one or two selected from the group of plants consisting of
More than one extract; (C) Fennel (Foeniculum vulgare Miller), To
Japanese cypress (Aesculus turbin ata Blume) and / or Seiyo
Uchinoki (Aesculus hippocastanum L.), carrot
(Daucus carota L.) extraction mixture; (D) Chamomile (Matricaria chamomilla L.), hop
(Humulus lupulus L.), Achillea millefolium (Achi
llea millefolium L.), Melissa (Melissa officinal
is L.), mistletoe (Viscum coloratum Nakai var.lut
escens Miyabe et Kudo orViscum album L. var.lutes
cens Makino), Mannenrou (Rosmarinus officinali
s L.), Daffodil ((Calendula officinalis 
L.), calendula (Calendula arvensis L.), Yagle
Magic (Centaurea cyanus L.), horsetail (Equisetum a
rvense L.), a plant belonging to the genus Eucalyptus (Eucalyptu
s spp.), plants belonging to the genus Aloe (Aloe spp.), Maru
Melo (Cydonia oblonga Mill.), Cucumber (Cucumis s
ativus L.), coltsfoot (Tussilago farfara 
L.), Below Aoi (Althaea officinalis L.), Oh
Plants belonging to the genus Epimedium (Hypericum spp.), salvi
A (Salvia officinalis L.) and its variants (Salvia of
ficinalis var.tenuior), Hamamelis (Hamamelis vi
rginiana L.), witch hazel (Hamamelis japonica Sieb.
et Zucc.),Thymus vulgaris 
L.), Tormentilla (Potentilla tormentilla),
Elephant (Glycyrrhiza uralensis Fisher,Glycyrrhiza g
labra L. and its variants,Glycyrrhiza echinata L.,Gly
cyrrhiza glandulifera Reg. Et Herd.), Belonging to the genus Lily
A plant (Lilium spp.), parsley (Petroselinum cris
pum (Mill.) Nym. Ex A.W.Hill.), Belongs to the genus Linden
Plant (Tilia spp.), plants belonging to the genus Birch (Betu
la spp.), beech (Fagus crenata Blume), Inubuna
(Fagus japonica Maxim.), Ginkgo (Ginkgo biloba
 L.), Kizuta (Hedera tobleri Nakai), Seiuki
Shreds (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis L.) one or two selected from the group of plants consisting of
More than one extract; (E) Chamomile (Matricaria chamomilla L.), Seiyo
Yarrow (Achillea millefolium L.), Otogi
Plants belonging to the genus LycorisHypericum spp.) 1 or 2
More than seed, coltsfoot (Tussilago farfara L.), Biro
Wood Aoi (Althaea officinalis L.), Salvia (Sa
lvia officinalis L.) and / or its variants (Salvia of
ficinalis var.tenuior) Extraction mixture; (F) Fennel (Foeniculum vulgare Miller), ho
Up (Humulus lupulus L.), Melissa (Melissa offi
cinalis L.), mistletoe (Viscum coloratum Nakai va
r.lutescens Miyabe et Kudo orViscum album L. va
r.lutescens Makino), horse chestnut (Aesculus turbinat
a Blume), Horse Chestnut (Aesculus hippocastanu
m L.), carrot (Daucus carota L.), Mannenrou
(Rosmarinus officinalis L.), Daffodil ((Cale
ndula officinalis L.), calendula (Calendula arve
nsis L.), cornflower (Centaurea cyanus L.), Su
Guina (Equisetum arvense L.), belonging to the genus Eucalyptus
Plant (Eucalyptus spp.), plants belonging to the genus Aloe (A
loe spp.), quince (Cydonia oblonga Mill.), Ki
Cucumber (Cucumis sativus L.), Hamamelis (Hamameli
s virginiana L.), witch hazel (Hamamelis japonica Si
eb. et Zucc.),Thymus vulgaris 
L.), Tormentilla (Potentilla tormentilla),
Elephant (Glycyrrhiza uralensis Fisher,Glycyrrhiza 
glabra L. and its variants,Glycyrrhiza echinata L.,Gl
ycyrrhiza glandulifera Reg. Et Herd.), Belonging to the genus Lily
A plant (Lilium spp.), parsley (Petroselinum cris
pum (Mill.) Nym. Ex A.W.Hill.), Belongs to the genus Linden
Plant (Tilia spp.), plants belonging to the genus Birch (Betu
laspp.), beech (Fagus crenata Blume), Inubuna (F
agus japonica Maxim.) Ginkgo (Ginkgo biloba 
L.), Kizuta (Hedera tobleri Nakai), Soil scratch
(Hedera helix L.) and Roman chamomile (Anthemis 
nobilis L.) 1 or 2 species selected from the group of plants
The above extracts; (G) Salvia (Salvia officinalis L.) and / or
Its variant (Salvia officinalis var.tenuior), Hama
Melis (Hamamelis virginiana L.), octopus otter
C (Thymus vulgaris L.), Tormentilla (Potentil
la tormentilla), Mannenrou (Rosmarinus officin
alis L.) extraction mixture; (H) Chamomile (Matricaria chamomilla L.), Wiki
Ryou (Foeniculum vulgare Miller), Hop (Humulus
 lupulus L.), Achillea millefolium (Achillea mill
efolium L.), Melissa (Melissa officinalis L.),
Mistletoe (Viscum coloratum Nakai var.lutescens Miy
abe et Kudo orViscum album L. var.lutescens Maki
no), horse chestnut (Aesculus turbinata Blume), Seiyo
Uchinoki (Aesculus hippocastanum L.), carrot
(Daucus carota L.), Daffodil ((Calendula of
ficinalis L.), calendula (Calendula arvensis 
L.), cornflower (Centaurea cyanus L.), Horsetail
(Equisetum arvense L.), a plant belonging to the genus Eucalyptus
object(Eucalyptus spp.), plants belonging to the genus Aloe (Aloe 
spp.), quince (Cydonia oblonga Mill.), Kyu
Li (Cucumis sativus L.), coltsfoot (Tussilago 
farfara L.), Below Aoi (Althaea officinalis 
L.), plants belonging to the genus Hypericum (Hypericum sp
p.), witch hazel (Hamamelis japonica Sieb. Et Zuc
c.), licorice (Glycyrrhiza uralensis Fisher,Glyc
yrrhiza glabra L. and its variants,Glycyrrhiza echinat
a L.,Glycyrrhiza glandulifera Reg. Et Herd.), Yu
Plants belonging to the genus Li (Lilium spp.), parsley (Petroseli
num crispum (Mill.) Nym. Ex A.W.Hill.), Linden
Plants belonging to the genus (Tilia spp.), plant belonging to the genus Birch
object(Betula spp.), beech (Fagus crenata Blume), Lee
Nubuna (Fagus japonica Maxim.), Ginkgo (Ginkgo 
biloba L.), Kizuta (Hedera tobleri Nakai), Say
Youzuki (Hedera helix L.) and Roman chamomile (A
nthemis nobilis L.) a plant selected from the group consisting of
Or a combination of any two or more extracts;
A plant extract consisting of collagen and elastin,
Rabi consists of solubilized products, hydrolysates and modified products.
Contains one or more selected from the group, and
Let

Further, in the present invention, the skin condition can be further improved by using two or more of the skin external preparations obtained as described above in combination.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The plant extraction mixture (A) used in the present invention is chamomile ( Matricaria chamomilla).
L.), fennel ( Foeniculum vulgare Miller), hop ( Humulus lupulus L.), yarrow ( A )
chillea millefolium L., Melissa offici
nalis L.) and mistletoe ( Viscum coloratum Nakai va
r. lutescens Miyabe et Kudo or Viscum album L. va
r. lutescens Makino).

The chamomile ( Matricaria chamomilla L.) is an annual or perennial plant belonging to the family Asteraceae ( Compositae ), and is a basic plant of the herbal medicine "Chamomillae Flos ". Each part of leaves, stems, roots, head flowers and the like and the whole plant can be used, but it is preferable to use head flowers.

Foeniculum vulgare Mille
r) is a perennial plant belonging to the Umbelliferae family and is the base plant of the herb medicine " Foeniculi Fructus ". Leaves, stems, roots, flowers, fruits and other parts and whole plants can be used. Preference is given to using fruits.

[0012] Hop ( Humulus lupulus L.) is a dioecious vine perennial belonging to the Moraceae family and is a base plant of the herbal medicine " Lupuli Strobilus ".
Each part of leaves, stems, roots, flowers and the like and the whole plant can be used, but it is preferable to use female spikes.

Achillea millefo
lium L.) is a perennial plant belonging to the family Asteraceae ( Compositae ),
Each part of leaves, stems, roots, flowers and the like can be used, but it is preferable to use flowers or whole plants.

[0014] Melissa (Melissa officinalis L.) is a perennial plant belonging to the Labiatae (Labiatae), leaves, stems, roots, it is possible to use the site and the whole plant flowers, etc., it is preferable to use a leaf.

Mistletoe ( Viscum coloratum Nakai var.
lutescens Miyabe et Kudo or Viscum album L. var. l
utescens Makino) is a dioecious evergreen semi-parasitic shrub belonging to the family Mistletoe ( Loranthaceae ). It can use leaves, branches, flowers, fruits, seeds, etc. It is preferable to use.

The above-mentioned 6 kinds of plants may be subjected to extraction at the same time, but they may be extracted individually and then the obtained extracts may be mixed. In addition, "MS Extract (Complex VII)" (Maruzen Pharmaceutical Co., Ltd.), "Sefplant Complex" (Kurrichter Co., Ltd.)
It is also possible to use a commercially available product such as.

In the present invention, each plant constituting the plant group of (B) used in combination with the extraction mixture of (A) will be described below.

Horse-chestnut ( Aesculus turbinata Blume) and horse chestnut ( Aesculus hippocastanum L.) are deciduous trees belonging to the horse chestnut family ( Hippocastanaceae ),
Each part of leaves, branches, bark, flowers, fruits and the like and whole trees can be used, but it is preferable to use leaves, bark or fruits.

The carrot ( Daucus carota L.) is a perennial herb belonging to the family Umbelliferae ( Umbelliferae ), and can be used for each part such as leaves, stems, roots and the whole plant, but it is preferable to use the root part.

Mannenrou ( Rosmarinus officinalis
L.) is an evergreen shrub belonging to Labiatae and has leaves,
Each part of the branch, bark, flower, etc. and the whole tree can be used, but it is preferable to use leaves.

Calendula officinalis
L.) and Calendula arvensis L. are first- and second-year herbs belonging to the Asteraceae ( Compositae ) family.
Each part of leaves, stems, flowers, roots, and the whole plant can be used, but it is preferable to use flowers.

Cornflower ( Centaurea cyanus L.) is an annual plant belonging to the family Asteraceae ( Compositae ), and includes leaves, stems, flowers,
Although various parts such as roots and whole plants can be used, it is preferable to use flowers.

Horsetail ( Equisetum arvense L.) is a perennial fern plant belonging to the family Equisetaceae , and can be used for each part of rhizome, spores, vegetative stem and whole plant, but whole plant is preferable. .

Examples of the plant belonging to the genus Eucalyptus include Eucalyptus globulus Labill. And its related plants. These are Myrtacaceae ( Myrtacaceae).
eae ), an evergreen tree, which is a crude drug "eucalyptus oil"
( Oleum Eucalypti ) is the basic plant. Related plants include Eucalyptus polybractea RTBaker, Eucalyptus
dives Schauer. In addition, lemon eucalyptus ( Eucalyptus citriodora Hook.), Eucalyptus piperi
ta Sm., Eucalyptus gunnii Hook. fil., Eucalyptus m
acarthuri Decne. Et Maiden, Eucalyptus rostrata Sc
hlecht., Eucalyptus staigeriana FvM and the like can also be used, and one kind or two or more kinds are selected from these and used for extraction. Each part of leaves, branches, bark, flowers, fruits and the like and whole trees can be used, but it is preferable to use leaves.

Plants belonging to the genus Aloe are Liliaceae (Liliacea
e) Is a woody succulent plant belonging toAlo
e) Is used as a base plant.Aloe ferox Mill.,A
loe africana Mill.,Aloe spicata Baker,Aloe arbor
escens Mill.,Aloe succotrina Lam.,Aloe plicatili
s Mill.,Aloe bainesii Th.Dyer.,Aloe marlothii Bg
r.,Aloe perryi Baker,Aloe vera L.,Aloe barbaden
sis Mill. And Kidachi Aloe (Aloe arborescens Mill.
var.natalensis Berg.) Etc., and from these 1
One kind or two or more kinds are selected and used. Leaves, flowers for extraction
Each part of stems, flowers, etc. and whole plants can be used, but leaves
It is preferable to use parts.

Quince ( Cydonia oblonga Mill.) Is a deciduous tree belonging to the family Rosaceae , and leaves, branches, bark,
Although it is possible to use all parts of flowers, fruits, etc. and whole trees,
Preference is given to using leaves or fruits.

[0027] Cucumber ( Cucumis sativus L.) is an annual vine plant belonging to the family Cucurbitaceae .
Although it is possible to use each part of flowers, fruits, etc. and whole grass,
Preference is given to using fruits.

The coltsfoot ( Tussilago farfara L.) is a perennial herb belonging to the family Asteraceae ( Compositae ).
Each site such as flowers and roots and whole plants can be used, but leaves or flowers are preferably used.

[0029] Bellows Aoi ( Althaea officinalis
L.) is a perennial plant belonging to the Malvaceae family.
Although various parts such as stems, flowers, and roots and whole plants can be used, it is preferable to use leaves or roots.

[0030] Examples of the plants belonging to the genus Hypericum, St. John's wort (Hypericum erectum Thunb.), Hypericum perforatum L., Tomoesou (Hyper to be produced in Europe
icumascyron L.) and these are Hypericumaceae ( Gu
ttiferae ) is a perennial herb that is used alone or in combination of two or more. Each part of leaves, stems, flowers, roots, and the whole plant can be used for the extraction, but it is preferable to use the whole plant.

Salvia ( Salvia officinalis L.) and its variant, Salvia officinalis var. Tenuior, are perennials belonging to Labiatae , and can be used for all parts of leaves, stems, flowers, roots and whole plants. However, it is preferable to use leaves.

Hamamelis virginiana L.
And Hamamelis japonica Sieb. Et Zucc. Are deciduous trees belonging to the family Hamamelidaceae .
Each part of the branch, bark, flower, etc. and the whole tree can be used, but it is preferable to use leaves.

[0033] Thymus vulgaris L.
Is an evergreen small shrub belonging to Labiatae , with leaves,
Although various parts such as stems, flowers and roots and whole plants can be used, it is preferable to use whole plants.

Tormentilla (Potentilla tormentill
a) Is a rose family (Rosaceae) Is a perennial herb belonging to
Each part of stems, flowers, roots and whole plants can be used
However, it is preferable to use roots.

Glycyrrhiza uralensis Fishe
r, Glycyrrhiza glabra L. and its variants, Glycyrrhiza
echinata L., Glycyrrhiza glandulifera Reg. et Her
d.) is a perennial plant belonging to the leguminous family ( Leguminosae ), and is a basic plant of the herb " Glycyrrhizae Radix ". A variant of Glycyrrhiza glabra L. is Glycyrrhi.
za glabra var.typica Regel et Herder, Glycyrrhiza
glabra var. violacea Boiss., Glycyrrhiza glabra va
r. pallida Boiss. 1 or 2 from the above
Select and use at least one species. For extraction, each part of leaves, stems, flowers, roots and the whole plant can be used, but it is preferable to use roots.

[0036] The plant belonging to the lily genus, gold-banded lily (Lili
um auratum Lindl.), Madonna Lily ( Lilium candid)
um L.), Himeyuri (Lilium concolor Salisb.), L. formosanum (Lilium formosanum Wallace), Sasayuri (L
ilium japonicum Thunb. ex Houtt.), Lili
um lancifolium Thunb.), Lilium leicht
linii Hook. f. var. maximowiczii Baker), Teppo lily ( Lilium longiflorum Thunb.), Iwato lily ( Lil
ium maculatum Thunb.), Lilium medeolo
ides A. Gray), Lilium regale Wil
s.), Otomeyuri (Lilium rebellum Baker), Lilium speciosum (Lilium speciosum Thunb.), and the like. These are perennials belonging to the family Liliaceae , and one or more species are selected and used. For extraction, each part of leaves, stems, flowers, stems and the like and whole plants can be used, but it is preferable to use stems.

Parsley ( Petroselinum crispum (Mill.) N
ym. ex AWHill.) is a perennial or perennial plant belonging to the family Apiaceae ( Umbelliferae ), and can be used for all parts of leaves, stems, flowers, fruits and the like, but it is preferable to use leaves and stems. .

The plants belonging to the genus Tilia include Tilia americana L. and Tili
a cordata Mill.), Tilia europae
a L.), linden (Tilia japonica Simonk.), Heranoki (Tilia kiusiana Makinoet Shiras.), Oba linden (Tilia maximowicziana Shiras.), linden (Tilia miqueliana Maxim.), Natsu linden (Tilia
platyphyllos Scop.) etc. These are deciduous trees belonging to the family Tiliaceae , one or two.
Select and use at least one species. For extraction, leaves, branches, bark,
Although it is possible to use all parts of flowers, fruits, etc. and whole trees,
Preference is given to using flowers or fruits.

Plants belonging to the genus Birch include Betula ermanii Cham. And Betula grossa Si.
eb. et Zucc.), sweet birch ( Betula lenta)
L.), Betula maximowicziana Rege
l), red birch ( Betula nigra L.), paper birch ( Betula papyrifera Marsh.), silver birch ( Be
tula pendula Roth.), birch ( Betula platyphylla )
Sukatchev var. Japonica Hara.), European birch ( Betula pubescens Ehrh,), Ono ore birch ( Betu
la schmidtii Regel), Himalayan Paper Birch ( Betu
la utilis D.Don) etc. These are birch ( Bet
ulaceae ) deciduous shrubs or trees, and one or more species selected and used. For extraction, each part of leaves, branches, bark, flowers, fruits, etc. and whole trees can be used, but it is preferable to use leaves or bark.

The beech (Fagus crenata Blume) and Fagus japonica (Fagus japonica Maxim.) Is a deciduous tree belonging to the beech family (Fagaceae), it is possible to use leaves, branches, bark, flowers, each site and all the trees of fruit, etc. However, it is preferable to use leaves, bark, or shoots.

Ginkgo biloba L. is a dioecious deciduous tree belonging to the family Ginkgoaceae .
Each part of leaves, branches, bark, flowers, seeds, and the whole tree can be used, but it is preferable to use leaves or seeds.

[0042] ivy (Hedera tobleri Nakai) and ivy (Hedera helix L.) is Araliaceae (Araliacea
The evergreen vines belonging to e ) can be used for each part of leaves, stems, flowers, berries, and whole plants, but it is preferable to use leaves and stems.

Roman chamomile ( Anthemis nobilis L.)
Is a perennial plant belonging to the family Asteraceae ( Compositae ).
Each part of flowers, roots, etc. and whole plants can be used, but it is preferable to use flowers.

Next, the plant extraction mixture of (C) is fennel ( Foeniculum vulgare Miller), horse chestnut ( Aesculu ).
s turbinata Blume) and / or horse chestnut ( Aes
culus hippocastanum L.), carrot ( Daucus carota
L.) each plant. These plants may be subjected to extraction at the same time, or may be extracted individually and then the obtained extracts may be mixed. In addition, "MS Extract (Complex X)" (manufactured by Maruzen Pharmaceutical Co., Ltd.),
Commercially available products such as "Chess Plant Complex" (manufactured by Kurtrichter Co., Ltd.) can also be used.

Used in combination with the plant extraction mixture of (C) (D)
The plant group of is Chamomile ( Matricaria chamomilla L.),
Hop ( Humulus lupulus L.), yarrow ( Achillea millefolium L.), Melissa ( Melissa off )
icinalis L.), mistletoe ( Viscum coloratum Nakai va
r. lutescens Miyabe et Kudo or Viscum album L. va
r. lutescens Makino), Mannenrou ( Rosmarinus of
ficinalis L.), Calendula officina
lis L.), Calendula (Calendula arvensis L.), cornflower (Centaurea cyanus L.), horsetail (Equiset
um arvense L.), a plant belonging to the genus Eucalyptus ( Eucal
yptus spp.), plants belonging to the genus Aloe ( Aloe spp.),
Quince ( Cydonia oblonga Mill.), Cucumber ( Cucum
is sativus L.), coltsfoot ( Tussilago farfara )
L.), Birodo aoi ( Althaea officinalis L.), plants belonging to the genus Hypericum ( Hypericum spp.), Salvia ( Salvia officinalis L.) and its variants ( Salvia of
ficinalis var. tenuior ), Hamamelis vi
rginiana L.), witch hazel (Hamamelis japonica Sieb.
et Zucc.), Thymus vulgaris
L.), Tormentilla ( Potentilla tormentilla ), Fern ( Glycyrrhiza uralensis Fisher, Glycyrrhiza)
glabra L. and its variants, Glycyrrhiza echinata L., Gl
ycyrrhiza glandulifera Reg. et Herd.), plants belonging to the genus Lily ( Lilium spp.), parsley ( Petroselinum cris
pum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Betul)
a spp.), beech ( Fagus crenata Blume), beech ( F
agus japonica Maxim.), Ginkgo biloba
L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemis
nobilis L.).

The plant extract mixture (E) is one or more of chamomile ( Matricaria chamomilla L.), Achillea millefolium L., and plants belonging to the genus Hypericum ( Hypericum spp.). Tussilago farfara L.), Below Aoi ( Alt
haea officinalis L.), Salvia officinali
s L.) and / or its variants ( Salvia officinalis var.
tenuior ) obtained from each plant. These plants may be subjected to extraction at the same time, but after extraction individually,
The obtained extracts may be mixed. Further, commercially available products such as "mixed plant extract (12)" (manufactured by Maruzen Pharmaceutical Co., Ltd.) can also be used.

Used in combination with the plant extraction mixture of (E) (F)
The plant group of fennel ( Foeniculum vulgare Mille
r), hops ( Humulus lupulus L.), Melissa ( Melis )
sa officinalis L.), mistletoe ( Viscum coloratum Na
kai var. lutescens Miyabe etKudo or Viscum album
L. var. Lutescens Makino), Horse chestnut ( Aesculus tur )
binata Blume), Horse chestnut ( Aesculus hippoca)
stanum L.), carrot (Daucus carota L.), rosemary (Rosmarinus officinalis L.), tow calendula (Calendula officinalis L.), calendula (Calend
ula arvensis L.), Cornflower ( Centaurea cyanus )
L.), horsetail ( Equisetum arvense L.), plants belonging to the genus Eucalyptus ( Eucalyptus spp.), Plants belonging to the genus Aloe ( Aloe spp.), Quince ( Cydonia oblonga Mil)
l.), cucumber ( Cucumis sativus L.), Hamamelis ( H
amamelis virginiana L.), witch hazel (Hamamelis japo
nica Sieb. et Zucc.), Thymus vu
lgaris L.), Tormentilla ( Potentilla tormentill )
a ), licorice ( Glycyrrhiza uralensis Fisher, Glycy
rrhiza glabra L. and its variants, Glycyrrhiza echinata
L., Glycyrrhiza glandulifera Reg. Et Herd.), Plants belonging to the genus Lily ( Lilium spp.), Parsley ( Petroselinu
m crispum (Mill.) Nym. Ex AWHill.), plants belonging to the genus Tilia ( Tilia spp.), plants belonging to the genus Birch ( Betula spp.), beech ( Fagus crenata Blume), beech ( Fagus japonica Maxim.), Ginkgo bi
loba L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthe
mis nobilis L.).

Furthermore, the plant extraction mixture of (G) is salvia ( Salvia officinalis L.) and / or its variants ( Sal).
via officinalis var. tenuior), Hamamelis (Hamame
lis virginiana L.), Thymus vulga
ris L.), Tormentilla ( Potentilla tormentill )
a ) and mannen wax ( Rosmarinus officinalis L.) plants. These plants may be subjected to extraction at the same time, or may be extracted individually and then the obtained extracts may be mixed. Further, commercially available products such as "MS extract (Complex XVI)" (manufactured by Maruzen Pharmaceutical Co., Ltd.) can also be used.

Combined with the plant extraction mixture of (G) (H)
The plant group of is chamomile (Matricaria chamomilla L.),
Fennel (Foeniculum vulgare Miller), Hop (H
umulus lupulus L.), Achillea millefolium (Achille
a millefolium L.), Melissa (Melissa officinalis 
L.), mistletoe (Viscum coloratum Nakai var.lutesc
ens Miyabe et Kudo orViscum album L. var.lutesce
ns Makino), horse chestnut (Aesculus turbinata Blum
e), horse chestnut (Aesculus hippocastanum
L.), carrot (Daucus carota L.), Calendula officinalis
(Calendula officinalis L.), calendula (Calendul
a arvensis L.), cornflower (Centaurea cyanus 
L.), horsetail (Equisetum arvense L.), Eucalyptus
Plants belonging to the genus (Eucalyptus spp.), belonging to the genus Aloe
Plant (Aloe spp.), quince (Cydonia oblonga Mil
l.), cucumber (Cucumis sativus L.), coltsfoot
(Tussilago farfara L.), Below Aoi (Althaea o
fficinalis L.), plants belonging to the genus Hypericum (Hyper
icum spp.), witch hazel (Hamamelis japonica Sieb. Et
 Zucc.), Licorice (Glycyrrhiza uralensis Fisher,
Glycyrrhiza glabra L. and its variants,Glycyrrhiza ech
inata L.,Glycyrrhiza glandulifera Reg. Et Her
d.), plants belonging to the genus Lily (Lilium spp.), parsley (P
etroselinum crispum (Mill.) Nym. Ex A.W.Hill.),
Plants belonging to the genus Tilia (Tilia spp.), to the birch genus
Plant to which (Betula spp.), beech (Fagus crenata Blu
me), beech (Fagus japonica Maxim.), Ginkgo
(Ginkgo biloba L.), Kizuta (Hedera tobleri Naka
i), Ivy (Hedera helix L.) and Romanka
Honey (Anthemis nobilis L.).

In the present invention, the plants constituting (A) to (H) may be subjected to extraction as they are, but in consideration of extraction efficiency, they are subjected to treatments such as shredding, drying and crushing. It is preferable to carry out the extraction later. The extraction is performed by immersing it in an extraction solvent. It may be stirred or homogenized in an extraction solvent in order to improve the extraction efficiency. The extraction temperature is 5
It is suitable to set the temperature at about 0 ° C to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is suitable to be about 4 hours to 14 days.

As the extraction solvent, in addition to water, methanol,
Lower alcohols such as ethanol, propanol and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin, ethers such as ethyl ether and propyl ether, esters such as ethyl acetate and butyl acetate. It is possible to use polar organic solvents such as acetone, ketones such as ethyl methyl ketone, etc., and one kind or two or more kinds are selected from these and used. Alternatively, physiological saline, phosphate buffer, phosphate buffered saline, etc. may be used.

The extract of each plant constituting the above (A) to (H) with the above solvent can be contained as it is in the external preparation for skin according to the present invention. It may be used after being redissolved in a polar solvent, or subjected to purification treatment such as decolorization, deodorization, and desalting within a range that does not impair their skin physiological function-improving action, or fractionation treatment by column chromatography. . For storage, it can be used after being purified and then freeze-dried and dissolved in a solvent before use. It can also be used by encapsulating it in vesicles such as liposomes or in microcapsules.

In each of the inventions according to the present application, one or two kinds selected from the group consisting of collagen and elastin, and solubilized products, hydrolyzed products, and modified products thereof together with each combination of the plant extracts described above. The above is used.

Collagen is a major protein component constituting animal connective tissue, and in skin tissue, it is a constituent protein of dermal matrix. For the purpose of the present invention, a solubilized product or a hydrolyzed product of collagen extracted from animal tissue, and a product obtained by modifying these with a chemical or enzymatic method are preferably used. Examples of the solubilized product include water-soluble collagen obtained by extraction from cow or pig skin, bone marrow tissue, placenta, etc., with water, ethanol or a mixed solvent thereof, an aqueous sodium chloride solution, fish skin such as cod or duckweed. Examples thereof include water-soluble collagen obtained by extraction from organs and atelocollagen obtained by removing telopeptides with an enzyme. As the hydrolyzate, bovine or porcine bone, skin, etc. can be treated with an acid, an alkali, an enzyme or the like. Examples thereof include collagen hydrolyzate obtained by hydrolysis by combination, collagen hydrolyzate obtained from fish skin and fish organs, and the like. Moreover, as a modified product,
Succinylation product of the atelocollagen, alkyl ester or alkenyl ester such as ethyl ester or hexadecyl ester of the hydrolyzate of collagen, alanine myristic acid condensate, isostearic acid condensate, coconut oil fatty acid condensate of the hydrolyzate of collagen, Condensates of fatty acids such as undecylenic acid condensates and resin acid condensates, their salts, and 3-chloro-2 of the above-mentioned collagen hydrolyzate
-Hydroxypropyltrimethylammonium chloride adduct, cationized modifications such as glycine trimethylammonium chloride adduct and salts thereof, addition modifications such as 3-glycidoxypropylmethyldihydroxysilane adduct of collagen hydrolyzate and their salts Examples thereof include salts.

Elastin is a structural protein found in highly extensible tissues such as arteries, tendons and skin.
For the purpose of the present invention, solubilized products and hydrolysates of elastin extracted from animal tissues, and those modified by a chemical or enzymatic method are preferably used,
Water-soluble elastin obtained by solubilizing elastin extracted by heat treatment with oxalic acid from bovine neck tendon, elastin hydrolyzate obtained by hydrolyzing bovine nuchal ligament, from fish skin such as cod Examples thereof include elastin hydrolysates obtained by elastase treatment, condensates of methylsilanol, N-acetylmethionine, lactic acid and the like, and salts thereof.

For the external preparation for skin according to the present invention, the above-mentioned collagen and elastin, and their solubilized products, hydrolyzed products and modified products, which are extracted and prepared from animal tissues at any time, may be used. -It is preferable in terms of quality and price to use a commercial product provided by each company as a raw material for pharmaceuticals.

The external preparation for skin according to the present invention can be provided in various dosage forms such as lotions, emulsions, gels, creams, ointments, powders and granules. In addition, skin cosmetics such as lotion, emulsion, cream, beauty essence, pack,
Makeup base lotion, base cosmetics such as makeup base cream, foundation of each dosage form such as milky liquid, oily, solid, etc., makeup cosmetics such as eye color, cheek color, cleansing cream, cleansing lotion, cleansing foam , It can also be provided as a skin cleansing agent such as face wash soap and body shampoo, and a hair cosmetic such as hair shampoo, hair rinse and hair treatment.

The external preparation for skin according to the present invention is selected from the group consisting of the plant extracts of groups (A) to (H), collagen and elastin, and their solubilized products, hydrolyzed products and modified products. In addition to one or two or more selected, other oily ingredients, surfactants, moisturizers, pigments, ultraviolet absorbers, antioxidants, fragrances, general pharmaceuticals such as antibacterial and antifungal agents, and cosmetics Raw materials and physiologically active ingredients such as skin cell activating agents, anti-inflammatory agents, and whitening agents can also be contained.

Further, in another aspect of the present invention, there is provided a skin care method characterized by selecting two or more kinds from the above-mentioned external preparation for skin according to the present application and using them in combination. By such a skin care method, the physiological functions of the skin are synergistically and comprehensively improved, the skin condition is improved, and the skin is kept healthier. The external preparation for skin can be arbitrarily selected, but one or more skin cosmetics and one or more skin cleansing agents, one or more skin cosmetics and one or more base cosmetics, and / or makeup are used. It is preferable to use one or more types of up cosmetics or a combination of the above and one or more types of skin cleansing agents.

[0060]

EXAMPLES The features of the present invention will be described in detail with reference to Examples. First, a preparation example of each plant extract used in the present invention is shown below.

[Plant Extract Mixture 1] Chamomile ( Matricar
ia chamomilla L.) flowers, fennel (Foeniculum vul
gare Miller) fruit, hops ( Humulus lupulus L.)
Female spikelets, Achillea millefoli
um L.) flowers, Melissa officinalis L. leaves, and mistletoe ( Viscum coloratum Nakai var. lute)
scens Miyabe et Kudo or Viscum album L. var. lutes
cens Makino) each 200g fruit is dried and crushed to 50
3% at 20 ° C in 1 liter of each volume% ethanol solution
After stirring and extracting for one day, the mixture was filtered to collect the filtrate, which was mixed in the same volume to obtain a plant extraction mixture 1.

[Plant Extraction Mixture 2] Fennel ( Foenic
ulum vulgare Miller) fruit, Horse Chestnut ( Aes)
culus hippocastanum L.) bark and carrot ( Daucus
150 g of each root of carota L.) is dried and crushed, and a mixture of ethanol and 1,3-butylene glycol (volume ratio = 1: 1)
After leaving still in 2.5 liters at room temperature for 5 days, it filtered and the filtrate was collect | recovered and it was set as the plant extraction mixture 2.

[Plant Extraction Mixture 3] Chamomile ( Matricar
200 g of ia chamomilla L.) flowers, 200 g of Achillea millefolium L. flowers, 225 g of Tussilago farfara L. flowers, and 180 g of roots of vellum aoi ( Althaea officinalis L.) are dried and crushed. After leaving still in 3 liters of 3,3-butylene glycol at room temperature for 5 days, the filtrate is collected by filtration.
On the other hand, 220 g of the whole plant of Hypericum erectum Thunb. And 300 g of the leaves of Salvia officinalis L. were homogenized in 2.5 liters of a 50 vol% aqueous ethanol solution at 15 ° C., extracted with stirring for 24 hours, and then centrifuged. After that, the supernatant is filtered to collect the filtrate. This filtrate and the above-mentioned filtrate were mixed at a volume ratio of 2: 1 to obtain a plant extraction mixture 3.

[0064] [plant extract mixture 4] salvia (Salvia o
fficinalis L.) leaves 250 g, Hamamelis
virginiana L.) leaves 250 g, pearl millet ( Th
Ymus vulgaris whole plant 300g of L.), root 250g of Torumentira (Potentilla tormentilla), dried leaves 280g of rosemary (Rosmarinus officinalis L.), and triturated at 15 ℃ with ethanol 2 liters of 7
It was left standing for a day for extraction. The filtrate was collected by filtration, concentrated to dryness, and then dissolved in 500 ml of 50% by volume ethanol to obtain a plant extraction mixture 4.

Next, with respect to the plants shown in Table 1, 250 g of each site shown in Table 1 was dried and pulverized, and allowed to stand at room temperature for 5 days in 1.5 liter of the solvent shown in Table 1 and then filtered. The liquid was collected and used as an extract of each plant.

[0066]

[Table 1]

For the plants shown in Table 2, 200 g of each part shown in Table 2 was cut into small pieces and the solvent 1 shown in Table 2 was used.
After stirring and extracting in liter at 20 ° C. for 3 days and filtering,
The filtrate was concentrated to 1/3 volume to obtain an extract of each plant.

[0068]

[Table 2]

Subsequently, for the plants shown in Table 3, 230 g of each site shown in Table 3 was finely crushed and crushed with 1 liter of the solvent shown in Table 3 at 20 ° C. for 3 days with stirring, and the back solution was filtered. It was concentrated to dryness and then freeze-dried to obtain an extract of each plant.

[0070]

[Table 3]

The formulations of the examples of the external preparation for skin according to the present invention are shown below. As the solubilized products of collagen and elastin used in the following examples, those commercially available as raw materials for cosmetics and pharmaceuticals, or those obtained by adding treatment such as hydrolysis to commercially available raw materials were used.

Examples 1 to 4 Cleansing Cream (1) Stearic Acid 2.00 (wt%) (2) Cetanol 3.00 (3) Vaseline 10.00 (4) Liquid Paraffin 38.00 (5 ) Isopropyl myristate 10.00 (6) Tocopherol acetate 0.10 (7) Glyceryl monostearate 2.50 (8) Polyoxyethylene (20 E.O.) sorbitan 2.50 Monostearate (9) Propylene Glycol 5.00 (10) Taraukibukuro extract Water-soluble collagen 0.20 (11) Potassium hydroxide 0.10 (12) Methyl paraoxybenzoate 0.10 (13) Plant extraction mixture shown in Table 4 0.05 (14 ) Plant extract shown in Table 4 Amount shown in Table 4 (15) Purified water Amount with total amount of 100.00 (16) Perfume 0.10 Production method: (1) to ( Mix the oil phase components of 8), dissolve by heating and 70 ℃
And On the other hand, mix and dissolve the water phase components (9) to (15) to obtain 7
Heat to 0 ° C. After gradually adding the oil phase to this aqueous phase component to pre-emulsify, homogenize with a homomixer,
Cool and add (16) at 40 ° C. and mix.

[0073]

[Table 4]

[Examples 5 to 8] Cleansing lotion (1) Ethanol 15.00 (wt%) (2) Polyoxyethylene (20 E.O.) sorbitan 1.00 Monolauric acid ester (3) Polyoxyethylene Polyoxypropylene 1.50 Block polymer (4) Methyl paraoxybenzoate 0.10 (5) Perfume 0.05 (6) Glycerin 5.00 (7) 1,3-Butylene glycol 10.00 (8) Bovine term ligament Extracted elastin hydrolysate 0.20 (9) Plant extraction mixture shown in Table 5 0.01 (10) Plant extract shown in Table 5 Amount shown in Table 5 (11) Purified water Total amount of 100.00 Production method : Dissolve (2) to (5) in (1) to make an ethanol phase.
On the other hand, (6) to (11) are mixed and dissolved to form an aqueous phase, and the ethanol phase is added to the aqueous phase to solubilize it.

[0075]

[Table 5]

[Examples 9 to 12] Cleansing foam (1) Stearic acid 10.00 (% by weight) (2) Palmitic acid 10.00 (3) Myristic acid 12.00 (4) Lauric acid 4.00 (5) Jojoba oil 2.00 (6) Polyethylene glycol 10.00 (average molecular weight 1,500) (7) Glycerin 15.00 (8) Palm oil fatty acid 0.25 condensate potassium salt of collagen hydrolyzate (9 ) Potassium hydroxide 6.00 (10) Methyl paraoxybenzoate 0.10 (11) Purified water Amount to make the total amount 100.00 (12) Glyceryl monostearate 2.00 Ester (13) Polyoxyethylene (20E. O.) Sorbitan 2.00 Monostearate (14) Plant extract mixture shown in Table 6 0.02 (15) Plant extract shown in Table 6 Amount shown in Table 6 (1 6) Perfume 0.10 Manufacturing method: Mix (1) to (7), heat and dissolve to 70 ° C.
(8) to (10) are dissolved in (11), and the oil phase is added with stirring to sufficiently carry out a neutralization reaction. Then (12), (13)
After adding, the mixture is cooled, and (14) to (16) are mixed and homogenized at 40 ° C. in advance, and then added and mixed.

[0077]

[Table 6]

[Examples 13 to 16] Lotion (1) Ethanol 10.00 (wt%) (2) Polyoxyethylene (20E.O.) sorbitan 0.50 Monolauric acid ester (3) Jojoba oil 0 10 (4) Methyl paraoxybenzoate 0.10 (5) Perfume 0.05 (6) 1,3-Butylene glycol 6.00 (7) Glycerin 4.00 (8) Cod peel elastin hydrolyzate 0.05 (9) Succinylated atelocollagen 0.05 (10) Plant extraction mixture shown in Table 0.01 0.01 (11) Plant extraction shown in Table 7 Amount shown in Table 7 (12) Purified water Total amount to be 100.00 Manufacturing method: (2) to (5) are dissolved in (1) to obtain an alcohol phase.
On the other hand, (6) to (12) are uniformly mixed and dissolved to form an aqueous phase.
The alcohol phase is added to this aqueous phase and mixed uniformly.

[0079]

[Table 7]

Examples 17 to 20 Emulsion (1) Cetanol 1.00 (wt%) (2) Beeswax 0.50 (3) Vaseline 2.00 (4) Squalane 6.00 (5) Dimethyl poly Siloxane 2.00 (6) Polyoxyethylene (20E.O.) sorbitan 1.00 Monostearic acid ester (7) Glyceryl monostearic acid ester 1.00 (8) Glycerin 4.00 (9) 1,3-butylene Glycol 4.00 (10) Bovine skin extracted water-soluble collagen 0.15 (11) Methyl paraoxybenzoate 0.10 (12) Purified water Amount to make the total amount 100.00 (13) Carboxyvinyl polymer 10.00 (1 0.0% by weight aqueous solution) (14) Potassium hydroxide 0.10 (15) Ethanol 5.00 (16) Perfume 0.10 (17) Plant extraction mixture shown in Table 8 0.04 ( 18) Plant extract shown in Table 8 Amount shown in Table 8 Manufacturing method: The oil phase components of (1) to (7) were mixed, heated and dissolved to give 75
℃. On the other hand, the aqueous phase components (8) to (12) are mixed and dissolved to 75 ° C. After adding the oil phase to this and pre-emulsifying, (13) is added, then (14) is added to thicken and then cooled, and (15) to (18) are added and mixed at 40 ° C. .

[0081]

[Table 8]

[Examples 21 to 24] Cream (1) Cetanol 5.00 (% by weight) (2) Stearic acid 3.00 (3) Vaseline 5.00 (4) Squalane 10.00 (5) Glyceryl Tri-2-ethylhexanoic acid 7.00 Ester (6) Propylene glycol monostearic acid 3.00 Ester (7) Polyoxyethylene (20 E.O.) cetyl ether 3.00 (8) d-δ-tocopherol 0.15 (9) 1,3-butylene glycol 5.00 (10) glycerin 5.00 (11) isostearic acid 0.25 collagen hydrolyzate condensate 2-amino-2-methyl-1,3-propanediol salt ( 12) Potassium hydroxide 0.20 (13) Plant extract mixture shown in Table 9 0.02 (14) Plant extract shown in Table 9 Amount shown in Table 9 (15) Amount of purified water to be 100.00 ( 16) Incense Material 0.10 Manufacturing method: Mix the oil phase components (1) to (8), dissolve by heating, and 70 ° C.
And On the other hand, after mixing and dissolving the water phase components (9) to (15), the mixture is heated to 70 ° C., and the oil phase is added thereto to emulsify. After cooling, (16) is added and mixed at 40 ° C.

[0083]

[Table 9]

[Examples 25 to 28] Packing agent (1) Polyvinyl alcohol 15.00 (% by weight) (2) Carboxymethyl cellulose 5.00 (3) 1,3-Butylene glycol 5.00 (4) Bovine Cervical extract Water-soluble elastin 0.15 (5) Plant extraction mixture shown in Table 10 0.02 (6) Plant extract shown in Table 10 Amount shown in Table 10 (7) Purified water Total amount to be 100.00 (8) Ethanol 12.00 (9) Methyl paraoxybenzoate 0.10 (10) Polyoxyethylene (10E.O.) oleyl ether 0.50 (11) Perfume 0.10 Production method: (7) to (3) After adding ~ (6), heat to 70 ° C, then
Add (1) and (2) and dissolve. (9) to (11) are added to (8) and dissolved, and then added to the aqueous phase to solubilize it.

[0085]

[Table 10]

Example 29 Lotion (1) Ethanol 20.000 (wt%) (2) Polyoxyethylene (60 E.O.) hydrogenated castor oil 0.500 (3) Methyl paraoxybenzoate 0.100 ( 4) Dipropylene glycol 5.000 (5) 1,3-butylene glycol 10.000 (6) Taraububukuro collagen hydrolyzate 0.100 (7) Bovine term ligament extract elastin hydrolyzate 0.100 (8) Plant Extraction mixture 4 0.020 (9) Roman chamomile extract 0.001 (10) Fennel extract 0.001 (11) Hop extract 0.001 (12) Achillea millefolium extract 0.001 (13) Melissa extract 0.001 (14) Mistletoe extract 0.001 (15) Horseradish extract 0.002 (16) Parsley extract 0.002 (17) Fuyudaiji Extract 0.010 (18) Birch extract 0.010 (19) Beech extract 0.010 (20) Purified water 64.140 Manufacturing method: (1) to (7) are mixed and dissolved, and (8) ) To (19) are sequentially added and dissolved, and then added to (20) and uniformly mixed and dissolved.

Example 30 Water-in-oil emulsion (1) Microcrystalline wax 1.000 (wt%) (2) Beeswax 2.000 (3) Lanolin 2.000 (4) Liquid paraffin 20.000 (5 ) Squalane 10.000 (6) Sorbitan sesquioleate 4.000 (7) Polyoxyethylene (20 E.O.) sorbitan 1.000 Monooleate (8) Propylene glycol 7.000 (9) Tarakibukuro collagen Hydrolyzate 0.150 (10) Cod skin elastin hydrolyzate 0.100 (11) Methyl paraoxybenzoate 0.100 (12) Plant extraction mixture 2 0.050 (13) Hamamelis extract 0.020 (14) Parsley extract 0.005 (15) Fuyubodaiju extract 0.005 (16) Birch extract 0.005 17) Beech extract 0.005 (18) Purified water 52.560 Preparation: (1) dissolved by heating a mixture of oil phase component to (7), 70
℃. On the other hand, the water phase components (8) to (18) are mixed, heated and dissolved to 70 ° C. This aqueous phase is added to the oil phase, emulsified with a homogenizer, and then cooled.

[Example 31] Oil-in-water cream (1) Beeswax 6.00 (% by weight) (2) Cetanol 5.00 (3) Reduced lanolin 8.00 (4) Squalane 27.50 (5) Glyceryl Fatty acid ester 4.00 (6) Lipophilic glyceryl monostearate 2.00 (7) Polyoxyethylene (20 E.O.) sorbitan 5.00 Monolaurate (8) Propylene glycol 5.00 (9) Cod Ukibukuro Collagen Hydrolyzate 0.20 (10) Succinylated Atelocollagen 0.05 (11) Cod Skin Elastin Hydrolyzate 0.05 (12) Methyl Paraoxybenzoate 0.10 (13) Purified Water 36.90 (14) Plant Extract Mixture 4 0.10 (15) Chamomile extract 0.01 (16) Yarrow extract 0.01 (17) Fukitan Popo extract 0.01 (18) Bildo mallow extract 0.01 (19) Hypericum extract 0.01 (20) Ginkgo extract 0.05 Production method: Mix the oil phase components of (1) to (7) , Melt by heating 75
℃. On the other hand, the water phase components (8) to (13) are mixed, dissolved and heated to 75 ° C. Next, the oil phase component is added to this aqueous phase component to pre-emulsify it, then homogenize with a homomixer, and after cooling, mix (14) to (20) in advance at 40 ° C, homogenize and add, mix. To do.

The above-mentioned examples of the present invention were subjected to a use test by a female panelist exhibiting remarkable skin roughening symptoms.
In the use test, 20 panelists per group were used, and each group was blinded to each of Example 15, Example 17, Example 31, and Comparative Example 15, Comparative Example 17, and Comparative Example 31 described later. Example 28 and Comparative Example 28 described later were used twice a day for 1 month at a frequency of 3 times a week for 1 month. Comparative Example 15, Comparative Example 17, Comparative Example 28 and Comparative Example 31 were prepared by blending plant extract, collagen and the like as shown in Table 11 in Example 15, Example 17, Example 28 and Example 31, and purifying them. The total amount was adjusted to 100% by weight with water. In addition, Example group 1 of the present invention shown in Table 12
Of the skin external preparation groups of Example group 2, Comparative example group 1 and Comparative example group 2, cleansing foam, lotion, emulsion and cream in the morning and cleansing cream, cleansing lotion, cleansing foam, lotion, emulsion in the evening , The skin was treated with cream for 1 month. Furthermore, during the 1-month use period, the use of packs
It was performed twice a week. Comparative group 1 and comparative group 2
Was prepared by substituting the plant extracts shown in Table 12 for all the plant extracts contained in each of the skin external preparations constituting Example group 1 and Example group 2.

[0090]

[Table 11]

[0091]

[Table 12]

With respect to the panelists of each group, the skin condition was observed and the water content of the stratum corneum was measured before and after the start of the use test, and the familiarity of the skin was evaluated for each sample.
In addition, during the use test period, an interview survey was conducted to find out if there was any feeling of skin irritation or abnormalities such as erythema or rash when the sample was used. The skin condition was evaluated and scored according to the evaluation criteria shown in Table 13, and the average value of 20 persons was calculated and shown. The stratum corneum water content was indicated by the measured value of skin surface conductance (μMuo). Regarding the familiarity with the skin, the feeling of skin irritation, and the presence or absence of skin abnormality, the results were scored according to the evaluation criteria shown in Table 14, and the average value of 20 persons was calculated. The results are summarized in Table 15.

[0093]

[Table 13]

[0094]

[Table 14]

[0095]

[Table 15]

In Table 15, in the use groups of Example 15, Example 17, Example 28 and Example 31 of the present invention, the skin condition was improved to a substantially good condition, and the stratum corneum water content was significantly increased. It is recognized that Further, in the groups using Example group 1 and Example group 2, more remarkable improvement in skin condition and increase in stratum corneum water content were observed. On the other hand, Comparative Example 15 containing only the plant extraction mixture 2,
Comparative Example 17 containing only Plant Extract Mixture 1, Comparative Example 28 containing extract of bovine neck extracted water-soluble elastin and fennel but not containing Plant Extract Mixture 3 and taraububu collagen collagen hydrolyzate. In each of the use groups of Comparative Example 31 containing only the elastin hydrolyzate, the improvement of the skin condition was observed, but the degree thereof was not sufficient, and the increase in the stratum corneum water content was larger than that of the corresponding use group of the Examples. Was significantly smaller. Even in the group using Comparative Example Group 1 and Comparative Example Group 2 composed of a skin external preparation containing only one kind of plant extract and collagen hydrolyzate, improvement in skin condition and increase in stratum corneum water content Was insufficient.

Furthermore, the examples and example groups of the present invention were evaluated as having good compatibility with the skin, and compared with the corresponding comparative examples and comparative example groups, respectively. The evaluation was also significantly higher. Further, regarding each sample used in the use test this time, no problematic skin irritation feeling or skin abnormality was observed as shown in Table 15, but in Examples and Example groups of the present invention,
A reduction tendency of skin irritation was observed as compared with the corresponding Comparative Examples and Comparative Example groups.

For each example of the present invention, 25 ° C.
When stored for 6 months, no change in state such as coloring, odor, aggregation, precipitation or deposition of contents components, and phase separation was observed.

[0099]

As described above in detail, according to the present invention, a high skin moisturizing effect, a beautiful skin effect and a rough skin improving effect are obtained.
Moreover, it was possible to obtain an external preparation for the skin, which had good compatibility with the skin and which was excellent in formulation stability and safety.

Front page continuation (51) Int.Cl. ⁷ Identification code FI A61K 7/00 A61K 7/00 U 7/50 7/50 35/78 35/78 W 38/00 A61P 17/16 38/17 A61K 37 / 12 A61P 17/16 37/18 (56) Reference JP-A-11-43425 (JP, A) JP-A-11-171758 (JP, A) JP-A-8-208424 (JP, A) JP-2000- 119155 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (2)

(57) [Claims] 1. An extractive mixture of a specific plant and a specific plant group
Combine one or more extracts selected from
A skin external preparation containing the following (A) and (B):
(C) and (D), (E) and (F), and (G)
Plant extract consisting of a combination of any one of (H)
And collagen and elastin and their
1 selected from the group consisting of solubilized products, hydrolyzed products, and modified products
External preparation for skin containing two or more species: (A) Chamomile (Matricaria chamomilla L.), Wiki
Ryou (Foeniculum vulgare Miller), Hop (Humulus
 lupulus L.), Achillea millefolium (Achillea mill
efolium L.), Melissa (Melissa officinalis L.) and
Mistletoe (Viscum coloratum Nakai var.lutescens 
Miyabe et Kudo orViscum album L. var.lutescens Ma
kino) extraction mixture; (B) Horse chestnut (Aesculus turbinata Blume), Seiyo
Uchinoki (Aesculus hippocastanum L.), carrot
(Daucus carota L.), Mannenrou (Rosmarinus off
icinalis L.), Daffodil ((Calendula officinal
is L.), calendula (Calendula arvensis L.), Yag
Rumagiku (Centaurea cyanus L.), horsetail (Equisetum
 arvense L.), a plant belonging to the genus Eucalyptus (Eucalyp
tus spp.), plants belonging to the genus Aloe (Aloe spp.), Ma
Lumello (Cydonia oblonga Mill.), Cucumber (Cucumis
 sativus L.), coltsfoot (Tussilago farfara 
L.), Below Aoi (Althaea officinalis L.), Oh
Plants belonging to the genus Epimedium (Hypericum spp.), salvi
A (Salvia officinalis L.) and its variants (Salvia of
ficinalis var.tenuior), Hamamelis (Hamamelis vi
rginiana L.), witch hazel (Hamamelis japonica Sieb.
et Zucc.),Thymus vulgaris
L.), Tormentilla (Potentilla tormentilla),
Elephant (Glycyrrhiza uralensis Fisher,Glycyrrhiza 
glabra L. and its variants,Glycyrrhiza echinataL.,Gly
cyrrhiza glandulifera Reg. Et Herd.), Belonging to the genus Lily
A plant (Lilium spp.), parsley (Petroselinum cris
pum (Mill.) Nym. Ex A.W.Hill.), Belongs to the genus Linden
Plant (Tilia spp.), plants belonging to the genus Birch (Betu
la spp.), beech (Fagus crenata Blume), Inubuna
(Fagus japonica Maxim.), Ginkgo (Ginkgo biloba
 L.), Kizuta (Hedera tobleri Nakai), Seiuki
Shreds (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis L.) one or two selected from the group of plants consisting of
More than one extract; (C) Fennel (Foeniculum vulgare Miller), To
Japanese cypress (Aesculus turbinata Blume) and / or Seiyo
Uchinoki (Aesculus hippocastanum L.), carrot
(Daucus carota L.) extraction mixture; (D) Chamomile (Matricaria chamomilla L.), hop
(Humulus lupulus L.), Achillea millefolium (Achi
llea millefolium L.), Melissa (Melissa officinal
is L.), mistletoe (Viscum coloratum Nakai var.lut
escens Miyabe et Kudo orViscum album L. var.lutes
cens Makino), Mannenrou (Rosmarinus officinali
s L.), Daffodil ((Calendula officinalis 
L.), calendula (Calendula arvensis L.), Yagle
Magic (Centaurea cyanus L.), horsetail (Equisetum a
rvense L.), a plant belonging to the genus Eucalyptus (Eucalyptu
s spp.), plants belonging to the genus Aloe (Aloe spp.), Maru
Melo (Cydonia oblonga Mill.), Cucumber (Cucumis s
ativus L.), coltsfoot (Tussilago farfara 
L.), Below Aoi (Althaea officinalis L.), Oh
Plants belonging to the genus Epimedium (Hypericum spp.), salvi
A (Salvia officinalis L.) and its variants (Salvia of
ficinalis var.tenuior), Hamamelis (Hamamelis vi
rginiana L.), witch hazel (Hamamelis japonica Sieb.
et Zucc.),Thymus vulgaris 
L.), Tormentilla (Potentilla tormentilla),
Elephant (Glycyrrhiza uralensis Fisher,Glycyrrhiza g
labra L. and its variants,Glycyrrhiza echinata L.,Gly
cyrrhiza glandulifera Reg. Et Herd.), Belonging to the genus Lily
A plant (Lilium spp.), parsley (Petroselinum cris
pum (Mill.) Nym. Ex A.W.Hill.), Belongs to the genus Linden
Plant (Tilia spp.), plants belonging to the genus Birch (Betu
la spp.), beech (Fagus crenata Blume), Inubuna
(Fagus japonica Maxim.), Ginkgo (Ginkgo biloba
 L.), Kizuta (Hedera tobleri Nakai), Seiuki
Shreds (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis L.) one or two selected from the group of plants consisting of
More than one extract; (E) Chamomile (Matricaria chamomilla L.), Seiyo
Yarrow (Achill ea millefolium L.), Otogi
Plants belonging to the genus LycorisHypericum spp.) 1 or 2
More than seed, coltsfoot (Tussilago farfara L.), Biro
Wood Aoi (Althaea officinalis L.), Salvia (Sa
lvia officinalis L.) and / or its variants (Salvia of
ficinalis var.tenuior) Extraction mixture; (F) Fennel (Foeniculum vulgare Miller), ho
Up (Humulus lupulus L.), Melissa (Melissa offi
cinalis L.), mistletoe (Viscum coloratum Nakai va
r.lutescens Miyabe et Kudo orViscum album L. va
r.lutescens Makino), horse chestnut (Aesculus turbinat
a Blume), Horse Chestnut (Aesculus hippocastanu
m L.), carrot (Daucus carota L.), Mannenrou
(Rosmarinus officinalis L.), Daffodil ((Cale
ndula officinalis L.), calendula (Calendula arve
nsis L.), cornflower (Centaurea cyanus L.), Su
Guina (Equisetum arvense L.), belonging to the genus Eucalyptus
Plant (Eucalyptus spp.), plants belonging to the genus Aloe (A
loe spp.), quince (Cydonia oblonga Mill.), Ki
Cucumber (Cucumis sativus L.), Hamamelis (Hamameli
s virginiana L.), witch hazel (Hamamelis japonica Si
eb. et Zucc.),Thymus vulgaris 
L.), Tormentilla (Potentilla tormentilla),
Elephant (Glycyrrhiza uralensis Fisher,Glycyrrhiza 
glabra L. and its variants,Glycyrrhiza echinata L.,Gl
ycyrrhiza glandulifera Reg. Et Herd.), Belonging to the genus Lily
A plant (Lilium spp.), parsley (Petroselinum cris
pum (Mill.) Nym. Ex A.W.Hill.), Belongs to the genus Linden
Plant (Tilia spp.), plants belonging to the genus Birch (Betu
laspp.), beech (Fagus crenata Blume), Inubuna (F
agus japonica Maxim.) Ginkgo (Ginkgo biloba 
L.), Kizuta (Hedera tobleri Nakai), Soil scratch
(Hedera helix L.) and Roman chamomile (Anthemis 
nobilis L.) 1 or 2 species selected from the group of plants
The above extracts; (G) Salvia (Salvia officinalis L.) and / or
Its variant (Salvia officinalis var.tenuior), Hama
Melis (Hamamelis virginiana L.), octopus otter
C (Thymus vulgaris L.), Tormentilla (Potentil
la tormentilla), Mannenrou (Rosmarinus officin
alis L.) extraction mixture; (H) Chamomile (Matricaria chamomilla L.), Wiki
Ryou (Foeniculum vulga re Miller), Hop (Humulus
 lupulus L.), Achillea millefolium (Achillea mill
efolium L.), Melissa (Melissa officinalis L.),
Mistletoe (Viscum coloratum Nakai var.lutescens Miy
abe et Kudo orViscum album L. var.lutescens Maki
no), horse chestnut (Aesculus turbinata Blume), Seiyo
Uchinoki (Aesculus hippocastanum L.), carrot
(Daucus carota L.), Daffodil ((Calendula of
ficinalis L.), calendula (Calendula arvensis 
L.), cornflower (Centaurea cyanus L.), Horsetail
(Equisetum arvense L.), a plant belonging to the genus Eucalyptus
object(Eucalyptus spp.), plants belonging to the genus Aloe (Aloe 
spp.), quince (Cydonia oblonga Mill.), Kyu
Li (Cucumis sativus L.), coltsfoot (Tussilago 
farfara L.), Below Aoi (Althaea officinalis 
L.), plants belonging to the genus Hypericum (Hypericum sp
p.), witch hazel (Hamamelis japonica Sieb. Et Zuc
c.), licorice (Glycyrrhiza uralensis Fisher,Glyc
yrrhiza glabra L. and its variants,Glycyrrhiza echinat
a L.,Glycyrrhiza glandulifera Reg. Et Herd.), Yu
Plants belonging to the genus Li (Lilium spp.), parsley (Petroseli
num crispum (Mill.) Nym. Ex A.W.Hill.), Linden
Plants belonging to the genus (Tilia spp.), plant belonging to the genus Birch
object(Betula spp.), beech (Fagus crenata Blume), Lee
Nubuna (Fagus japonica Maxim.), Ginkgo (Ginkgo 
biloba L.), Kizuta (Hedera tobleri Nakai), Say
Youzuki (Hedera helix L.) and Roman chamomile (A
nthemis nobilis L.) a plant selected from the group consisting of
Or two or more kinds of extracts. 2. A skin care method, which comprises using two or more kinds selected from the external preparations for skin according to claim 1 in combination.