JP2003192528A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antiphotoaging cosmetic comprising ingredients (A) one or more kinds of vegetable extracts having phototoxicity reducing actions and (B) a fish-derived collagen. <P>SOLUTION: This antiphotoaging cosmetic comprises the vegetable extracts having the phototoxicity reducing actions and a solution of the fish-derived collagen. The resultant cosmetic has excellent stability and exhibits excellent actions on the skin. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an anti-photoaging cosmetic having an action of suppressing photoaging of the skin.

[0002]

BACKGROUND OF THE INVENTION Skin aging characterized by wrinkle and tarmi is caused by a decrease in collagen production by fibroblasts, a decrease in hyaluronic acid synthesis, an increase in collagenase activity by ultraviolet rays, damage by active oxygen generated by ultraviolet rays and the environment, and Is believed to be due to the phototoxic effects of ultraviolet air pollutants. An ultraviolet absorber, retinol, retinoic acid, and the like are used to improve wrinkles and tarmi caused by such light. In addition, collagen, a plant extract and the like having a phototoxicity reducing action are also used.

[0003]

Although an ultraviolet absorber, retinol, retinoic acid, etc. are used for the improvement of wrinkles and tarmi, side effects are strong from the viewpoint of safety. In addition, collagen, a plant extract, etc. having a phototoxicity reducing action are used, but since they show only a weak effect, when they are individually added to cosmetics, etc.,
A sufficient anti-aging effect, that is, an effect of improving wrinkle and tarmi was not obtained.

[0004] Therefore, it has been desired to develop a highly safe cosmetic composition having no side effect with respect to an excellent effect of improving wrinkles and tarmi.

[0005]

[Means for Solving the Problems] Due to such circumstances,
As a result of intensive studies by the present inventors for the purpose of improving photoaging of the skin, one or more selected from plant extracts having a phototoxicity-reducing effect, and a fish-derived collagen-containing material,
They have found that they have an excellent effect of suppressing photoaging of the skin, and have completed the present invention.

That is, the present invention provides the following components (A) and (B); (A) one or more selected from plant extracts having a phototoxicity-reducing action, and (B) a skin containing fish-derived collagen. It is an anti-photoaging cosmetic.

The plant extract of the component (A) used in the present invention is not particularly limited as long as it has a phototoxicity-reducing action, but is preferably coltsfoot, echinacea, stevia, chamomile, pearl millet, cornflower, yarrow, Kawamura mugwort, arnica, roman chamomile, white tea, bayberry, red sea bream, citrus unshiu, Japanese red citrus, mulberry, Scutellaria baicalensis, swordfish, spruce, spruce, horse chestnut, rosemary, sage, melissa, armature, honeysuckle and the like.

The solvent to be extracted is, for example, water, lower alcohols (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohol (glycerin, propylene glycol, 1). , 3-butylene glycol, etc.), ketones (acetone, methyl ethyl ketone, etc.), acetonitrile, esters (ethyl acetate, butyl acetate, etc.), hydrocarbons (hexane, heptane, liquid paraffin, etc.), ethers (ethyl ether, propyl, etc.) Ether, tetrahydrofuran, etc.). Water, lower alcohols and liquid polyhydric alcohols are preferable, and water, ethanol, propylene glycol and 1,3-butylene glycol are particularly preferable. These solvents may be used alone or in combination of two or more.

The extracted solutions may be used as they are, or if necessary, they may be subjected to treatments such as concentration, dilution and filtration, and decolorization and deodorization treatment with activated carbon before use. Furthermore, the extracted solution may be concentrated to dryness, spray-dried, freeze-dried and the like and used as a dried product.

The amount of component (A) used in the present invention is not particularly limited, but is preferably 0.0001% by weight in terms of solid content based on the total amount of the cosmetic of the present invention.
The above is preferable, and 0.0005 to 10% by weight is more preferable. If it is less than 0.0001% by weight, it is difficult to exert a sufficient effect. When it is blended in an amount of more than 10% by weight, the effect is not enhanced so much and it is uneconomical. Regarding the method of addition, it may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

Among these, the component (A) is used alone or in combination of two or more in the cosmetic of the present invention.

The fish-derived collagen which is the component (B) used in the present invention is not particularly limited, but for example, skins such as salmon, goldfish, codfish, flounder and the like or a floating bag are washed, degreased, acid filtered, treated with an enzyme, After means such as salt folding, dialysis, and heat treatment,
The thing obtained after extracting a solubilized collagen component is mentioned. These are used in commercial cosmetics as a fish-derived collagen solution. It may or may not be atherogenic.

The solution may be used as it is, and if necessary,
Concentration, dilution, filtration, etc. and decolorization with activated carbon, etc.
It may be used after being deodorized. Furthermore, the extracted solution may be concentrated to dryness, spray-dried, freeze-dried and the like and used as a dried product.

The blending amount of the component (B) used in the present invention is not particularly limited, but is preferably 0.0001% by weight or more in terms of solid content based on the total amount of the cosmetic of the present invention, and more preferably. Is preferably 0.00001 to 10% by weight. If it is less than 0.0001% by weight, it is difficult to exert a sufficient effect. When it is blended in an amount of more than 10% by weight, the effect is not enhanced so much and it is uneconomical. Regarding the method of addition, it may be added in advance or may be added during the production,
It may be selected as appropriate in consideration of workability.

As the component (B), one kind or two or more kinds of them are blended in the cosmetic of the present invention.

Oils, waxes, hydrocarbons, fatty acids, which are components used in ordinary cosmetics and quasi drugs, within a range that does not impair the effects of the components (A) and (B).
Alcohols, esters, surfactants, metal soaps, p
Ingredients such as H-adjusting agents, preservatives, fragrances, humectants, powders, ultraviolet absorbers, thickeners, dyes, antioxidants, whitening agents and chelating agents can also be added.

The cosmetic of the present invention can be used in both cosmetics and quasi-drugs.
Examples thereof include lotions, creams, emulsions, gels, aerosols, essences, packs, detergents, bath agents, foundations, dusters, lipsticks and the like.

[0018]

EFFECT OF THE INVENTION The cosmetic composition of the present invention brings about an effect of suppressing photoaging of the skin due to an excellent effect of improving wrinkles and tarmi.

[0019]

EXAMPLES In order to explain the present invention in detail, examples of production of extracts used in the present invention, prescription examples of the present invention and experimental examples will be given below, but the present invention is not limited thereto. Absent. The parts of the compounding amounts shown in the examples are parts by weight, and% is% by weight.

Production Example 1 Hot water extract of coltsfoot, 400 ml of purified water was added to 40 g of dried coltsfoot, and the mixture was extracted at 95 to 100 ° C. for 2 hours, filtered, and the filtrate was concentrated and freeze-dried. 1.2 g of hot water extract was obtained.

Production Example 2 Ethanol extract of Echinacea 900 mL of ethanol was added to 100 g of dried Echinacea, and the mixture was extracted at room temperature for 7 days, filtered, and the filtrate was concentrated to dryness to give 1. 5 g was obtained.

Preparation Example 3 Stevia 1,3-butylene glycol aqueous solution extract Stevia dried product 200 g 1 kg purified water and 1 k
1,3-butylene glycol (g) was added, and the mixture was extracted at room temperature for 7 days and then filtered to obtain 1.9 g of 1,3-butylene glycol aqueous solution extract.

Production Example 4 Acid-Soluble Atelolated Collagen Solution Salmon skin is washed, defatted, acid-treated, membrane-filtered, salted-out and dialyzed to obtain an acid-soluble collagen solution. For example, an “acid-soluble atelocollagen collagen solution” (Ihara Suisan: dry residue 1%) can be mentioned.

Production Example 5 Water-Soluble Collagen Solution An acid-soluble collagen solution is obtained through washing treatment, degreasing, acid treatment, membrane filtration, enzyme treatment, salting out, isoelectric focusing and dialysis. For example, "water-soluble collagen solution" (manufactured by Technoble: dry residue 1%) can be mentioned.

Production Example 6 Cattle-derived atelolated collagen solution Cowhide is washed, defatted, acid-treated, membrane-filtered, enzyme-treated, salted-out, isoelectrically precipitated and dialyzed to obtain an acid-soluble collagen solution. For example, an aqueous solution having a dry residue of 1% can be used.

Example 1 Cream 1 formulation Compounding amount 1. Hot water extract of coltsfoot (Production Example 1) 0.05 parts 2. Acid-soluble atelo-collagen solution (Production Example 4) 0.1 3. Squalane 5.5 4. Olive oil 3.0 5. Stearic acid 2.0 6. Beeswax 2.0 7. Octyldodecyl myristate 3.5 8. Polyoxyethylene cetyl ether (20 EO) 3.0 9. Behenyl alcohol 1.5 10. Glycerin monostearate 2.5 11. Fragrance 0.1 12.1, 3-butylene glycol 8.5 13. Ethyl paraoxybenzoate 0.05 14. Methyl paraoxybenzoate 0.2 15. [Manufacturing method] The total amount is 100 with purified water. Components 3 to 10 are dissolved by heating and mixed, and 70
Keep at ℃ and use as oil phase. Ingredients 1, 2 and 12 to 15 are dissolved by heating and mixed, and the mixture is kept at 75 ° C to form an aqueous phase. The aqueous phase is added to the oil phase to emulsify, the mixture is cooled with stirring, component 11 is added at 45 ° C, and further cooled to 30 ° C to obtain a product.

Comparative Example 1 Conventional Cream 1 A conventional cream 1 was prepared by replacing components 1 and 2 with purified water in Example 1.

Comparative Example 2 Conventional Cream 2 A conventional cream 2 was prepared by replacing the hot water extract of the component 1 in Example 1 with purified water.

Comparative Example 3 Conventional Cream 3 In Example 1, the conventional cream 3 was prepared by replacing the component 2 with purified water.

Example 2 Cosmetic lotion formulation Amount 1. 1. Echinacea ethanol extract (Production Example 2) 0.1 part 2. Acid-soluble atelocollagen collagen solution (Production Example 4) 0.01 3.1,3-butylene glycol 8.0 4. Glycerin 2.0 5. Xanthan gum 0.02 6. Citric acid 0.01 7. Sodium citrate 0.1 8. Ethanol 5.0 9. Methyl paraoxybenzoate 0.1 10. Polyoxyethylene hydrogenated castor oil (40 EO) 0.1 11. Perfume 0.1 12. [Manufacturing method] The total amount is 100 with purified water Components 1 to 7 and 12 and components 8 to 11 are uniformly dissolved, and both are mixed and filtered to obtain a product.

Example 3 Emulsion formulation Compounding amount 1. Echinacea ethanol extract (Production Example 2) 0.5 part 2. Acid soluble atelocollagen collagen solution (Production Example 4) 5.0 3. Squalane 5.0 4. Olive oil 5.0 5. Jojoba oil 5.0 6. Cetanol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene cetyl ether (20 EO) 3.0 9. Polyoxyethylene sorbitan monooleate (20 EO) 2.0 10. Perfume 0.1 11. Propylene glycol 1.0 12. Glycerin 2.0 13. Methyl paraoxybenzoate 0.2 14. [Manufacturing method] The total amount is 100 with purified water. Components 3 to 9 are dissolved by heating and mixed, and the mixture is heated to 70 ° C.
Keep it in the oil phase. Ingredients 1, 2 and 11 to 14 are dissolved by heating and mixed, and the mixture is kept at 75 ° C to form an aqueous phase. The water phase is added to the oil phase to emulsify, and the mixture is cooled with stirring, component 10 is added at 45 ° C, and further cooled to 30 ° C to obtain a product.

Example 4 Gel formulation Formulation amount 1. Hot water extract of coltsfoot (Production Example 1) 0.1 part 2. Acid-soluble atelocollagen collagen solution (Production Example 4) 1.0 3. Ethanol 5.0 4. Methyl paraoxybenzoate 0.1 5. Polyoxyethylene hydrogenated castor oil (60 EO) 0.1 6. Fragrance 0.1 7.1, 1,3-butylene glycol 5.0 8. Glycerin 5.0 9. Xanthan gum 0.1 10. Carboxyvinyl polymer 0.2 11. Potassium hydroxide 0.2 12. [Production method] Components 1 to 6 and components 7 to 12 each having a total amount of 100 with purified water are uniformly dissolved, and both are mixed to obtain a product.

[0033]   Example 5 Pack Prescription amount 1. 0.2 parts of 1,3-butylene glycol aqueous solution extract of stevia (Production Example 3) 2. Water-soluble collagen solution (Production Example 5) 10.0 3. Polyvinyl alcohol 12.0 4. Ethanol 5.0 5.1,3-butylene glycol 8.0 6. Methyl paraoxybenzoate 0.2 7. Polyoxyethylene hydrogenated castor oil (20EO) 0.5 8. Citric acid 0.1 9. Sodium citrate 0.3 10. Perfume 0.1 11. Adjust the total volume to 100 with purified water [Production method] Components 1 to 11 are uniformly dissolved to obtain a product.

Example 6 Foundation Formulation Amount 1. 1.0 part of 1,3-butylene glycol aqueous solution extract of stevia (Production Example 3) 1. Acid-soluble atelocollagen solution (Production Example 4) 0.05 3. Stearic acid 2.4 4. Polyoxyethylene sorbitan monostearate (20EO) 1.0 5. Polyoxyethylene cetyl ether (20 EO) 2.0 6. Cetanol 1.0 7. Liquid lanolin 2.0 8. Liquid paraffin 3.0 9. Isopropyl myristate 6.5 10. Butyl paraoxybenzoate 0.1 11. Carboxymethyl cellulose sodium 0.1 12. Bentonite 0.5 13. Propylene glycol 4.0 14. Triethanolamine 1.1 15. Methyl paraoxybenzoate 0.2 16. Titanium dioxide 8.0 17. Talc 4.0 18. Bengal 1.0 19. Yellow iron oxide 2.0 20. Perfume 0.1 21. [Production method] Components 3 to 10 are heated and dissolved in purified water to a total amount of 100 and kept at 80 ° C to form an oil phase. Ingredient 21 is swelled well into ingredient 21, and subsequently ingredients 1, 2 and 12 to 15 are added and mixed uniformly. Components 16 to 19 pulverized and mixed with a pulverizer are added to this, and the mixture is stirred with a homomixer and kept at 75 ° C to form an aqueous phase. Add the oil phase to this water phase while stirring and cool.
Add component 20 at 5 ° C and cool to 30 ° C with stirring to obtain a product.

Example 7 Formulation of bath agent Blending amount 1. 1.0 part of 1,3-butylene glycol aqueous solution extract of stevia (Production Example 3) Water-soluble collagen solution (Production Example 5) 0.1 3. Sodium hydrogen carbonate 50.0 4. Yellow No. 202 (1) 0.1 5. Fragrance 0.1 6. [Manufacturing method] The total amount is 100 with anhydrous sodium sulfate. Components 1 to 6 are uniformly mixed to obtain a product. As components 1 and 2, freeze-dried products are used.

Next, in order to explain the effects of the present invention in detail, experimental examples will be given.

Experimental Example-1 Effective amount of collagen derived from fish The effective amount of collagen derived from fish against reduction in skin elasticity after ultraviolet irradiation was examined. In the experiment, the back of 6-week-old male mice was irradiated with ultraviolet A waves, and the cream of Comparative Example 1 was applied with or without the hot water extract of coltsfoot, or with some amounts of collagen mixed. Irradiation and application 30
The test was conducted continuously for a day, and the skin elasticity was measured after the test was completed.

The results are shown in Table 1. The control shows the elasticity of mouse skin not irradiated with ultraviolet rays. It was effective by adding coltsfoot hot water extract to reduce skin elasticity. The improvement effect of fish-derived collagen depends on its amount,
An excellent effect was shown at 01% or more. However, no enhancement of the effect was observed even if the content was more than 10%.

[0039]

[Table 1] Effective amount of collagen derived from fish

Experimental Example 2 Phototoxicity-reducing action Balb / c 3T3 cells were used, and a medium containing benzpyrene, which is a typical air pollutant, was added to a hot water extract of coltsfoot dandelion (Production Example 1) and acid-soluble atelocollagen. The cell viability was measured when the solution (Production Example 4) and both substances were added, and when both the hot water coltsfoot extract and the bovine-derived atelocollagen collagen solution of Production Example-6 were added.

As a result, as shown in Table 2, the cell viability was 60% by the treatment with the hot water extract of coltsfoot, 20% by the treatment with the acid-soluble atelocollagen collagen solution, and 70% by the simultaneous treatment thereof. The survival rate was shown, and the phototoxicity reducing effect of the coltsfoot extract was confirmed. However, the effect of the hot water coltsfoot extract was not observed by the bovine-derived atelocollagen solution.

[0042]

[Table 2] Phototoxicity reduction effect

Experimental Example-3 Improvement effect on wrinkle / talmi Using the cream of Example-1 and the conventional creams of Comparative Examples-1 to 3, 20 women (25 to 40 years old) suffering from skin wrinkles and fine wrinkles. ) Was used for a one-month use test. After use, the effect of improving skin tarmi and fine wrinkles was evaluated by self-report.

As a result, as shown in Tables 3 and 4, cosmetics characterized by containing coltsfoot and salmon-derived acid-soluble atelo-collagen collagen solution showed excellent improving effects.

[0045]

[Table 3] Improvement effect on skin tarmi

[0046]

[Table 4] Improvement effect for small wrinkles

The cosmetics obtained in Examples 2 to 7 all showed a sufficient effect of improving wrinkles and tarmi.

[0048]

From the above, the present invention of the present invention comprises the following components (A) and (B); (A) one or more selected from plant extracts having a phototoxicity-reducing action, and (B) fish. The anti-photoaging cosmetics, which are characterized by containing the collagen derived therefrom, were excellent in stability and showed an excellent effect on the skin.

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Seika Akaza             2-7 Torimicho, Nishi-ku, Nagoya-shi Japan Menard             Cosmetics Research Institute (72) Inventor Hajime Kojima             2-7 Torimicho, Nishi-ku, Nagoya-shi Japan Menard             Cosmetics Research Institute (72) Inventor Tomonori Katata             2-7 Torimicho, Nishi-ku, Nagoya-shi Japan Menard             Cosmetics Research Institute F-term (reference) 4C083 AA082 AA111 AA112 AA122                       AB032 AB232 AB242 AB312                       AB352 AB432 AB442 AC022                       AC072 AC102 AC122 AC182                       AC242 AC302 AC352 AC422                       AC432 AC482 AC542 AC842                       AD092 AD112 AD272 AD352                       AD431 AD432 AD512 CC02                       CC04 CC05 CC07 CC12 CC25                       DD31 DD41 EE12 EE13 EE17

Claims (7)

[Claims] 1. A makeup comprising the following components (A) and (B); (A) one or more selected from plant extracts having a phototoxicity-reducing action, and (B) fish-derived collagen. Fee 2. A cosmetic according to claim 1, which is an anti-photoaging cosmetic containing the component according to claim 1. 3. The method according to claim 1, which has a phototoxicity reducing action.
Cosmetics 4. The amount of component (A) is 0.000 as solid content.
5-10% by weight, amount of component (B) 0.00001-10
% Of cosmetics according to claim 1 or 3. 5. Component (A) is coltsfoot, echinacea,
Stevia, chamomile, quince, cornflower,
Achillea millefolium, sagebrush, arnica, roman chamomile, white tea, bayberry, red sea bream, citrus unshiu, mandarin orange, mulberry, chafer, sorghum, spruce, spruce, horse chestnut, rosemary, sage, melissa, spruce seeds, watermelon The cosmetics according to claims 1 to 4 selected above 6. The component (A) comprises coltsfoot, echinacea,
Cosmetics according to claims 1 to 5 selected from stevia 7. The cosmetic composition according to claim 1, wherein the component (B) is an acid-soluble atelocollagen collagen solution or a water-soluble collagen solution.