JPH05124937A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic, having excellent hair tonic action such as prevention of alopecia and trichogenous effects and useful in the field of medicines, quasi-drugs and cosmetics. CONSTITUTION:A hair tonic is obtained by blending one or more alkoxypyridine- N-oxides expressed by the formula (R is 2-17C straight-chain or branched alkyl), e.g. 2-methoxypyridine-N-oxide as an active ingredient in an amount of 0.001-20wt.%, preferably 0.1-10wt.% in the hair tonic. The hair tonic has powerful hair tonic action. The hair tonic is administered by percutaneous administration of direct application or spraying on the skin. The dose varies with age, individual difference, symptoms, etc., however, it is usually daily 0.01-100mg, preferably 0.1-10mg per kg body weight in the case of administration to humans. The dose is administered once or 2-4 times a day. Furthermore, besides the above-mentioned ingredient, a vasodilator, amino acids, vitamins, nicotinic acid esters, skin hyperfunctional agents, female sex hormonal agents, etc., may simultaneously be blended in the hair tonic.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent having excellent hair loss-preventing and hair-growing effects. The present invention is particularly used in the fields of medicines, quasi drugs, and cosmetics.

[0002]

2. Description of the Related Art Conventionally, the causes of baldness and hair loss are activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxides. Abnormalities of the scalp are considered. For this reason, conventional hair nourishing agents are generally blended with compounds having the action of removing or reducing the above causes.

For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as cembly extract and acetylcholine derivative, anti-inflammatory agents such as purple root extract and hinokitiol, and female hormone agents such as estradiol. , A skin function-enhancing agent such as cepharanthin, and the like are used for the prevention and treatment of alopecia.

[0004]

BRIEF Problem to be Solved] However the prior art problems, the conventional hair tonic is dandruff, itching, effective in the prevention and amelioration of such hair loss, it has been to promote hair growth or hair growth, hair loss and outgoing The mechanism of hair is very complicated. Sufficient hair loss prevention and hair growth effects could not be observed only by inhibiting male hormone activation and increasing blood flow to hair follicles by conventional hair nourishing agents.

An object our invention In view of the above circumstances, is effective against hair loss, excellent hair loss prevention, explored the substance having a hair revitalizing action such as hair effect results, the following general formula, It has been found that the alkoxypyridine N-oxide represented by Chemical formula I has a strong hair-feeding effect, and the present invention has been completed.

[0006]

(In the formula, R represents a linear or branched alkyl group having 2 to 17 carbon atoms.)

[0007]

That is, the present invention is a hair nourishing agent characterized in that one or more of the alkoxypyridine N-oxides represented by the following general formula, Formula I, is added as an active ingredient.

[0008]

Embedded image (wherein R represents a linear or branched alkyl group having 2 to 17 carbon atoms). The constitution of the present invention will be described in detail below.

Alkoxypyridine N used in the present invention
-Oxide is represented by the following general formula

[0010]

(In the formula, R represents a linear or branched alkyl group having 2 to 17 carbon atoms.)

The compound represented by the chemical formula 2-
Methoxypyridine N-oxide, 3-methoxypyridine N-oxide, 4-methoxypyridine N-oxide, 2-ethoxypyridine N-oxide, 3-ethoxypyridine N-oxide, 4-ethoxypyridine N-
Oxide, 2-n-propoxypyridine N-oxide, 3-iso-propoxypyridine N-oxide, 4-
tert-butoxypyridine N-oxide, 2-n-butoxypyridine N-oxide, 3-iso-butoxypyridine N-oxide, 2-tert-butoxypyridine N-oxide, 2-iso-pentyloxypyridine N-oxide, 4 -Neopentyloxypyridine N-oxide,
2-n-pentyloxypyridine N-oxide, 2-
Neopentyloxypyridine N-oxide, 2-n-
Hexyloxypyridine N-oxide, 2-n-heptyloxypyridine N-oxide, 2-octyloxypyridine N-oxide, 4-octyloxypyridine N-oxide, 4- (1-methylheptyloxy) pyridine N-oxide, 2-n-nonyloxypyridine
N-oxide, 2- (2-methyloctyloxy) pyridine N-oxide, 2- (1-butylpentyloxy) pyridine N-oxide, 4-n-nonyloxypyridine
N-oxide, 4- (1-butylpentyloxy) pyridine N-oxide, 2-n-decyloxypyridine N-
Oxide, 3-n-decyloxypyridine N-oxide, 4-n-decyloxypyridine N-oxide, 2
-N-undecyloxypyridine N-oxide, 4-
n-dodecyloxypyridine N-oxide, 2-n-
Tridecyloxypyridine N-oxide, 3-n-tridecyloxypyridine N-oxide, 4-n-tridecyloxypyridine N-oxide, 2-n-heptadecyloxypyridine N-oxide, 4-n-heptadecyl Oxypyridine N-oxide, 2- (1-octylnonyloxy) pyridine N-oxide and the like.

Alkoxypyridine N used in the present invention
-Oxide is obtained by a known method, and its content is 0.001 to 20% by weight, preferably 0.1 to 10% by weight in the hair nourishing agent of the present invention.

The hair nourishing agent according to the present invention includes, in addition to alkoxypyridine N-oxide, vasodilators such as carpronium chloride, cembly extract and acetylcholine derivative, amino acids such as serine and methionine, vitamin B, vitamin E and its derivatives, Vitamin such as biotin, pantothenic acid and its derivative, glycyrrhetinic acid and its derivative, nicotinic acid ester such as benzyl nicotinate,
A skin function enhancer such as cepharanthin and a female hormone agent such as estradiol may be simultaneously added. Furthermore, additives usually used in hair nourishing agents, for example, hinokitiol, hexachlorophene, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid,
Antibacterial agents such as trichlorocarbanilide and bithionol, cooling agents such as menthol, salicylic acid, zinc and its derivatives, drugs such as lactic acid and its alkyl esters,
Organic acids such as citric acid, proteas such as tranexamic acid
Ze inhibitors, amino acids such as arginine, olive oil, squalane, liquid paraffin, isopropyl myristate, oils such as higher fatty acids and higher alcohols, polyhydric alcohols such as glycerin and propylene glycol, other surfactants, fragrances, antioxidants , UV absorber, dye,
Ethanol, water, a moisturizer, a thickener, etc. can be appropriately added within a range that does not impair the effects of the present invention.

The hair nourishing agent of the present invention may have any properties as long as it has properties applicable to the outer skin such as liquid, emulsion and ointment. The hair nourishing agent of the present invention is administered by percutaneous administration by directly applying or spraying on the skin. Further, the dose of the hair nourishing agent of the present invention cannot be clearly determined because it varies depending on age, individual difference, medical condition, etc., but generally when administered to humans, the dose is 1 kg of body weight and 0.01 to 100 mg per day, preferably Is
It is 0.1 to 10 mg, and this amount can be administered once a day or divided into 2 to 4 times a day.

[0015]

The hair nourishing agent of the present invention is a hair nourishing agent having excellent hair-removing effects such as hair loss prevention and hair growth effect.

[0016]

EXAMPLES Next, the production method and the hair-retaining action of the hair nourishing agent of the present invention will be described more specifically with reference to Examples. The present invention is not limited to this. The blending amount is% by weight. (Production method) Alkoxypydiline N- in 95% ethanol
Oxide and hydrogenated castor oil ethylene oxide (40 mol)
An adduct was added and dissolved by stirring, and then ion-exchanged water was added and mixed to obtain a liquid hair nourishing agent of Example 1. Tables 1-4
Examples 2 to 21 and Comparative Example 1 shown in Table 1 were also obtained in the same manner as in Example 1.

[0017]

[Table 1]

[0018]

[Table 2]

[0019]

[Table 3]

[0020]

[Table 4]

[Hair Growth Test] Examples 1 to 21 and Comparative Example 1
Hair growth test of C3H / HeNCr in the resting period of hair cycle
Using the J mouse, the method of Ogawa et al. (Normal and Abnormal Epidermal Differentiation N
ormal and Abnormal Epidermal Differentiation, M.Se
Edited by iji and IA Bernstein, pp. 159-170, 1982
1st year, University of Tokyo). That is, one mouse
Group 10 animals, no coating, Examples 1-21 and Comparative Example 1-23
The mice were divided into groups, the backs of the mice were shaved with a clipper and a shaver, and 0.1 ml of each sample was applied once a day. The hair-growth effect of each sample was measured by measuring the hair-growth part on the back of the mouse and compared by area ratio. Depends on each sample
Table 5 shows the number of days required for a 50% hair growth rate.

[0022]

[Table 5]

As is clear from Table 5, the hair nourishing agent according to the present invention has an excellent hair growth effect.

[Hair nourishing test] Next, in order to examine the hair nourishing effects such as hair loss prevention and hair growth effects of the hair nourishing agent of the present invention, a trichogram test was conducted on humans. The hair nourishing agents of Examples 1 to 21 and Comparative Example 1 were used. (Trichogram test) The hair roots of the removed hair before and after the use of the hair nourishing agent are observed under a microscope, the number of resting hair roots is counted from the form of the hair roots, and the hair nourishing effect of the hair nourishing agent is compared by increasing or decreasing the ratio. did. Resting hair roots are hair roots of hairs that have stopped growing, and it has been recognized that people who complain of hair loss have a higher proportion of resting hair roots than normal people. Each hair nourishment of Examples 1 to 21 and Comparative Example 1 was applied to the scalp of 10 male subjects twice a day, 2 ml each, continuously for 6 months,
Immediately before the application and immediately after the application for 6 months, 100 hairs were removed from each subject, and each hair root was examined.
The results are shown in Tables 6-8.

[0025]

[Table 6]

[0026]

[Table 7]

[0027]

[Table 8] As is clear from Tables 6 to 8, the hair nourishing agent according to the present invention is
It has an excellent hair nourishing effect.

Example 22% by Weight (Phase A) 3-Butoxypyridine N-Oxydone 1.0 Polyoxyethylene (60 mol) Addition-cured castor oil 2.0 Glycerin 10.0 Dipropylene glycol 10.0 1,3-Butylene glycol 5.0 Polyethylene glycol 1500 5.0 Phase B) Cetyl isooctanate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2.0 (C phase) 1% aqueous solution of carboxyvinyl polymer 30.0 Sodium hexametaphosphate 0.03 Ion exchanged water 8.35 (D phase) Ion exchanged water 4.5 (E phase) Causticari 0.12 Ion exchange Water 5.0 (Manufacturing method) Phases A and B are melted by heating at 60 ° C, mixed, and homogenized to form a gel. Phase D is gradually added to this and dispersed by a homomixer. Next, dissolved C phase was added thereto, and finally dissolved E phase was added and emulsified with a homomixer to obtain an o / w emulsion type hair nourishing agent. When this hair nourishing agent was subjected to a practical use test on humans as in Example 1, it was confirmed that the hair nourishing action was excellent.

Example 23% by Weight (Phase A) 4-Isopropoxypyridine N-Oxide 2.0 Liquid Paraffin 5.0 Cetostearyl Alcohol 5.5 Glyceryl Monostearate 3.0 EO (20 mol) -2-Octyldodecyl Ether 3.0 Propylparaben 0.3 Perfume 0.1 (Phase B) Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Ion-exchanged water 48.095 (Production method) Phases A and B are dissolved by heating and mixed, respectively,
The mixture was emulsified with a homomixer to obtain a creamy hair nourishing agent. When this hair nourishing agent was subjected to a practical use test on humans as in Example 1, it was confirmed that the hair nourishing effect was excellent.

[Chemical 1]

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Shirotaro Nakanishi, 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Institute Inside the research institute (72) Inventor Minoru Fukuda 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Research Center

Claims (1)

[Claims] 1. A hair nourishing agent comprising one or more alkoxy pyridine N-oxides represented by the following general formula and Formula I as an active ingredient. (In the formula, R represents a linear or branched alkyl group having 2 to 17 carbon atoms.)