JPH06247832A - Hair growth agent - Google Patents

Abstract

PURPOSE:To obtain a hair growth agent having excellent hair growth effects and ultrahigh safety with hardly any irritation to the skin without any side effects. CONSTITUTION:This hair growth agent comprises an ingredient obtained from an extract solution, a pressed juice, a sap, etc., of Lagenaria leucantha Rusby var. clavata Makino. The ingredient of the Lagenaria leucantha Rusby var. clavata Makino is obtained from an extract solution prepared by extracting the Lagenaria leucantha Rusby var. clavata Makino or a dried substance thereof with a solvent such as water, alcohols, ketones, ethers or chloroform or a mixed solvent thereof, the pressed juice obtained by chopping the Lagenaria leucantha Rusby var. clavata Makino and pressing the chopped Lagenaria leucantha Rusby var. clavata Makino with a filter press, etc., or the sap prepared by cutting a vine of the Lagenaria leucantha Rusby var. clavata Makino during the cultivation and collecting the dripped sap. The solution or liquid containing the ingredient of the Lagenaria leucantha Rusby var. clavata Makino is directly used or diluted or concentrated to a suitable concentration and daily directly applied to the skin about once to twice. The existing effective substance, e.g. a peripheral vasodilator or an antiinflammatory agent in an adequate amount may be contained therein for use.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hair-growing agent containing an evening glory component.

[0002]

2. Description of the Related Art The agents contained in hair-growing agents currently on the market are those aiming to expand peripheral blood vessels to enhance blood circulation, and to improve the condition of the scalp by the cleansing, anti-inflammatory or bactericidal effect of the scalp. Mainly aimed at improving.

Vitamin E, capsicum extract, cembly extract and the like are used as agents for peripheral vasodilation, glycyrrhizin and diphenhydramine hydrochloride are used as anti-inflammatory agents, and hinokitiol and resorcin are used as bactericidal agents. There is.

[0004]

However, the conventional hair restorers are effective in preventing and improving dandruff, itchiness, hair loss and the like, and promote hair growth and hair growth, but still exhibit satisfactory effects. Things have not been obtained.

On the other hand, the evening glory (Lagenaria sci)
neraria) is an annual vine of the Cucurbitaceae family, and has been eaten as a dried gourd (the flesh of the evening face was stripped into strips and dried), but it is still known that its ingredients have a strong hair-growing effect. Absent.

An object of the present invention is to provide a novel hair-growth agent having a high hair-growth effect.

[0007]

Means for Solving the Problems As a result of intensive studies on hair-growth agents, the present inventors have found that the components of the evening hair have a very strong hair-growth effect, and have completed the present invention.

The composition of the evening glory in the present invention is obtained from the extract, squeezed liquid, sap, etc. of the evening glory collected by various methods as described below, and it is not limited to the fruits of the evening glory and any part (flower, Leaves, vines, roots, etc.) may be used.

[0009] Evening face or dried face (such as dried gourd) is cut into small pieces, for example, water, alcohols such as methanol, ethanol, isopropanol, ketones such as acetone, ethers such as diethyl ether, solvents such as chloroform, or the like. Extract using the mixed solvent of. The obtained extract is concentrated, the solvent is distilled off, and then redissolved in water or ethanol water of an appropriate concentration. The extraction may be either cold soaking or hot soaking, but it is usually preferably carried out at a temperature of 40 to 60 ° C. for several hours to several days.

The evening face is shredded and squeezed using a filter press or the like. The obtained compressed liquid is filtered or centrifuged to remove a small amount of insoluble matter.

The vine on the evening glory during cultivation is cut to collect the dripping sap. The sap thus obtained is filtered or centrifuged to remove the slightly remaining insoluble matter.

The above is an example of a method for producing a liquid containing the composition of the evening glory, and the constituent of the evening glory in the present invention may be obtained from the evening glory by any method other than the above.

The thus-obtained liquid containing the composition of the evening glory is applied as it is or diluted or concentrated to an appropriate concentration and directly applied to the skin once or twice a day. Further, an existing effective substance such as a peripheral vasodilator or an anti-inflammatory agent may be contained in an appropriate amount and used. Further, a surfactant such as polyoxyl stearate 40 (JP) is added in an amount of about 0.1 to 5.0%, preferably 0.3 to 1.0% for the purpose of improving the application characteristics to the skin. You may use it.

[0014]

EXAMPLES The present invention will be specifically described below with reference to examples.

[Preparation of sample] 6.5 kg of evening glory fruit was shredded and squeezed with a filter press to obtain a squeezing liquid of 3500 m.
1 was obtained. This liquid was concentrated under reduced pressure to a liquid volume of 350 ml (1/10 amount), and further centrifuged at 10000 rpm for 30 minutes to obtain a clear evening glory fruit squeezed liquid as a supernatant solution.

Yufuo fruit squeezing liquid 10 obtained as described above
0.5 g of polyoxyl stearate 40 was added to 0 ml to give a product of the present invention. Further, 0.5 g of polyoxyl stearate 40 was added to 100 ml of purified water to give a comparative product.

[Test for confirming hair-growth effect] Male C3H mice on the 55th day of life in which the back hair was in a quiescent phase were shaved so as not to damage the back. These were divided into 3 groups of 12 animals per group, of which 1 group was a control group to which no sample was applied, and the remaining 2 groups were applied with the respective samples on the shaving part every day. A breeding experiment for 4 weeks was conducted for a total of 3 groups,
The next growth of hair was observed.

During the breeding period, the area of the site where hair growth was observed on the skin surface was measured daily, and the ratio (hair growth rate) to the area of the shaved part was determined.

It should be noted that food (commercial breeding,
Breeding solid samples) and water were available ad libitum. Further, the breeding room temperature was 25 ° C., the humidity was 60%, and the breeding was carried out under constant conditions with a dark and light setting in a 12-hour cycle. The results are shown in Table 1.

[0020]

[Table 1]

In the group to which the product of the present invention was applied, hair growth was recognized earlier than in the group to which the comparative product was applied. Also, the hair growth rate was extremely superior.

[0022]

EFFECTS OF THE INVENTION The hair restorer of the present invention has a very excellent hair restorer effect and is extremely safe with little skin irritation and no side effects.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Makoto Kusakabe 3 588, Kubota-cho, Ashikaga City, Tochigi Prefecture Tokyo Tanabe Seiyaku Co., Ltd. Ashikaga Plant

Claims (1)

[Claims] 1. A hair restorer containing an evening glory component.