JPS63303913A - Hair nourishing cosmetic - Google Patents

Abstract

PURPOSE:To obtain a hair nourishing cosmetic durability promoting blood circulation of scalp, having excellent growing effects on the hair, preventing effects on removal of hair and dandruff, containing an extract of pericarp of Lansium domesticum Jack var. duke, essence of Swertia japonica Makino and gamma-amino-butyric acid. CONSTITUTION:A hair nourishing cosmetic containing (A) 0.01-10.0wt.% extract of pericarp of Lansium domesticum Jack duke or Lansium domesticum Jack langat, a 5alpha reductase activity inhibitor, (B) 1.0-20.0wt.% essence of Swertia japonica Makino and (C) 0.01-0.5wt.% diisopropylamine dichloroacetate, showing excellent effects by synergistic actions of the three components.

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a hair nourishing cosmetic that is excellent in hair nourishing and hair growing effects. More specifically, the present invention relates to a hair nourishing cosmetic that continuously promotes blood circulation in the scalp and has excellent hair growth, hair loss prevention, and dandruff prevention effects.

(Prior Art) Hair nourishing cosmetics containing scalp blood circulation promoting substances such as capsicum tincture, Jasmine japonica extract, Korean ginseng extract, nicotinic acid, and methyl nicotinate have been well known.

However, these blood circulation promoting substances are highly irritating to the skin, and there are restrictions on the amount they can be added.The blood circulation promoting effect decreases in a short period of time, or the blood circulation promoting effect is weak. However, the substance was not effective enough to exhibit sufficient effects such as preventing dandruff.

(Disclosure of the Invention) Therefore, as a result of extensive research into natural extracts, blood circulation promoting substances, and cell activators that are highly effective when incorporated into hair-growth cosmetics, the present inventors discovered that Randium domesticum jack Extract obtained from the pericarp of Burduke or Randium domesticum jack burlantha, Oriental japonica extract, diisopropylamine dichloroacetate or T-
A hair nourishing cosmetic characterized by containing aminobutyric acid,
It causes very little skin irritation and continuously promotes blood circulation in the scalp.
The present inventors have discovered that it suppresses sebum secretion and has excellent effects on hair growth, hair loss prevention, dandruff prevention, etc., and has completed the present invention.

(Object of the invention) The object of the invention is to provide a hair-growth cosmetic that continuously promotes blood circulation in the scalp, suppresses sebum secretion, and has excellent effects on hair growth, hair loss prevention, and dandruff prevention. . (Structure of the Invention) The present invention provides an extract obtained from the pericarp of R. domesticum jack barduke or R. domesticum jack barlansa, a Japanese japonica extract, and diisopropylamine dichloroacetate or γ-aminobutyric acid. It is a hair nourishing cosmetic characterized by containing.

(Specific explanation of composition) The extract obtained from the pericarp of Randium domesticum jack barduke or Randium domesticum jack barlansa used in the present invention is disclosed in Japanese Patent Application Laid-Open No. 60-2430.
It is a 5α-reductase activity inhibitor described in Publication No. 20, and is a known substance. The method for producing it is described in the same publication, and as in Reference Examples 1 to 4, it is extracted with ethanol, hexane, ethyl acetate, etc. Any other extraction solvent may be used as long as it is suitable for the respective operation, such as pentane, hexane, heptane, aliphatic hydrocarbons such as cyclohexane, benzene, aromatic hydrocarbons such as toluene, quizylene, methylene chloride, etc. , chloroform, halogenated hydrocarbons such as carbon tetrachloride, alcohols such as methanol and ethanol, water, diethyl ether, petroleum ether, ethyl acetate, acetone, or a mixture of two or more of these solvents. . Although not all of the components of these pericarp have been elucidated, the main ones have been isolated and their structures determined.

The main ingredients are known as rancic acid and its glycosides, randioside A, B, and C.

All of these substances have physiological activity and can be used as an extract as in Reference Example 1 of JP-A No. 60-243020, or in the form of isolated components as in Reference Examples 2 to 4. . Furthermore, ranciic acid, which is the main component, and its glycosides, rangioside A, B, and C, also have physiological activity and can be used.

In addition, an outline of the method for producing Oriental japonica extract, which is a natural product extract, will be described below.

[Production method of Aspergillus japonica extract]

Swertia Japonica Mak
This is an extract obtained by digesting a dried, pulverized product of the whole flowering plant of P. ino) in ethanol or aqueous ethanol and filtering it. In the Examples, an extract obtained by the following method was used.

50g of crushed Aspergillus japonica was added to water-containing ethanol (ethanol 9
After digesting at a temperature of 40 to 50"C for 250 days (0 wt%), the residue was digested in the same manner again, and the extract 1
．． I got 51. This was concentrated under reduced pressure, and purified water was added to the residue.
After adding 0011 and aging for - weeks, the insoluble portion was filtered off and the obtained extract was concentrated under reduced pressure. Then, ethanol was added to adjust the ethanol content of the extract to 40 wt%, to obtain a 1001d Scutellariae extract. Ta.

As a result of extensive research into the above-mentioned constituents to be incorporated into hair-growth cosmetics, the present inventors have found that the present invention contains (i) pericarp extract, (it) Jasperia japonica extract, and (iii) diisopropylamine dichloroacetate or r- Hair nourishing cosmetics that contain aminobutyric acid at the same time have a synergistic effect,
It was clearly observed that it has excellent hair growth effects (mouse hair growth promotion effect, human hair growth promotion effect), hair growth effect, and dandruff prevention effect.

In other words, the king ingredients (i), (it), and (iii) act synergistically on the scalp to expand the peripheral blood vessels of the scalp, normalize the metabolic function of hair matrix cells, and enhance the anti-dandruff effect. It was possible to achieve excellent results.

In addition, the blending ratio of components such as pericarp extract in the hair-nourishing cosmetic may be adjusted as appropriate depending on the effect of each component or the dosage form of the hair-nourishing cosmetic, but based on the total amount ( i) is 0.01 to 1000 wt%, (it) is 1.0 to 20.0 wt%, and (iii) is O0 old to 0.
5 wt% is sufficient, and below the lower limit of each blending amount,
This is not sufficient to achieve the desired effect of the present invention, and on the other hand, even if the upper limit is exceeded, an improvement in effect commensurate with the increase cannot be expected.

The hair nourishing cosmetic of the present invention can be made into a hair tonic, hair lotion, hair cream, etc. according to a conventional method. Preservatives, keratolytic agents, anti-androgens, hair tonics, antioxidants, etc. may be appropriately incorporated within the range that achieves the purpose of the present invention (Example) The following is a detailed description of the present invention based on Examples and Comparative Examples. explain.

The mouse hair growth promotion test, human hair growth promotion test, and practical test are shown below.

(1) Mouse hair growth promotion test dd) F-strain white mouse (male, 6 weeks old, average weight 30 g)
After cutting the dorsal skin from the tail with electric clippers, the hair was completely removed with hair removal cream, and from the next day, each sample of the Examples and Comparative Examples was applied to the test skin twice a day in the morning and evening, O, O, per animal.
1I111! I clothed it. Ten animals per group were used for one sample.

The hair growth effect was determined by comparing the hair length of the sample application area with that of the control group.

On the 15th day after the start of the experiment, the animals were sacrificed and the skin at the test site was punched out and dried, and the lengths of 20 hairs therein were measured, and the average value of each hair was measured.

(2) Heat hair growth promotion test The heads of 10 test subjects who were male pattern baldness patients were shaved in a circular shape with a diameter of 1 cm at two locations on the left and right, 5 cm above the ears. The sample of Example or Comparative Example was applied to the test site twice a day in the morning and evening for about 3 jd, and compared with the untreated right side. To judge the effectiveness, on the 28th day after the start of the test, 20 hairs each on the left and right test sites were shaved, and the average length of the 20 hairs on the left side (where Example or Comparative Example was applied) (B) was divided by the average length (A) of 20 hairs on the right side (untreated) for evaluation.

The results of the judgment are (B)/(A) for each of the 10 test subjects.
It is shown as the average value.

(3) Practical test Samples were applied to the heads of 20 test subjects suffering from androgenetic alopecia twice a day in the morning and evening for 6 consecutive months, and then the effects were evaluated. The test results showed that "grown hair became bristly or increased,""hair loss decreased," and "dandruff decreased." It is shown by the number of people who answered "Yes."

Examples 1 to 12, Comparative Examples 1-11 [Oily Hair Tonic] Rancic acid (hereinafter abbreviated as LA) obtained according to the description in Reference Example 2 of JP-A No. 60-243020 with the following raw material composition. ), Landioside A, B, C
(hereinafter abbreviated as LS, Reference Example 2), pericarp ethanol extract (hereinafter abbreviated as LAEE, Reference Example 1), hexane extract (hereinafter abbreviated as LAHE, Reference Example 3), and Jasmine japonica extract , diisopropylamine dichloroacetate (hereinafter abbreviated as DADA), T
-Aminobutyric acid (hereinafter abbreviated as GABA) was mixed to prepare each hair tonic, and the various tests described above were conducted.

(1) Composition (2) Preparation method Component (B) is dissolved in component (A) and component (D) is dissolved in component (C). After heating each to 80 ° C and uniformly dissolving,
After cooling to 30°C, component (8) and component (C) are mixed, stirred and dispersed, and then filled into a container.

When using, shake and disperse the contents evenly (3)
Characteristics Tables 1 and 2 show the results of various Artonic tests performed on each oil.

As shown in Table 1, when the base of Comparative Example 1 was used alone, the hair growth promoting effect was low, and no hair growth or dandruff preventing effect was observed. In addition, LA, which is the main component of the pericarp extract of the present invention,
LAEE, LAEE or assembly extract, DADA,
Comparative Examples 2 to 7, in which GABA was blended alone, and Comparative Examples 8 to 11, in which GABA was blended alone, and Comparative Examples 8 to 11, in which GABA was blended alone, had slightly improved hair growth promoting effects, hair nourishing, and dandruff prevention effects compared to Comparative Example 1. However, in contrast, the pericarp extract of the present invention and
The hair nourishing cosmetics of the present invention of Examples 1 to 12, in which the three components of Aspergillus japonica extract and DADA or GABA were simultaneously blended, as shown in Table 2 (showing clearly good results in all of the tests). In Examples 1 to 12, no skin irritation occurred in various tests on human skin.

Examples 13 to 24 Comparative Examples 12 to 22 [Scalp Treatment] Each scalp treatment was prepared in the same manner as in the Oitsuhe Artonic Example and various tests were conducted, and the results are shown in Tables 3 and 4. 1) Composition (2) Preparation method Component (B) is dissolved in component (A), component (D) is dissolved in component (C), and after uniformly dissolving, component (A) and component (C). Each was heated and melted at 80°C and mixed.

Each scalp treatment was then prepared by cooling to 30°C while stirring.

(3) Properties As shown in Table 3, when the base of Comparative Example 1 was used alone, the effect of promoting hair growth was low, and no hair nourishing or dandruff preventing effect was observed. In addition, LAE, which is the main component of the pericarp extract of the present invention,
E., LAEE or Aspergillus extract, DADA, GA
In Comparative Examples 1g to 17 in which BA was blended alone and Comparative Examples 19 to 22 in which three of these champion ingredients were blended, Comparative Example 1
Slightly improved hair growth promoting effect, hair nourishing effect, and dandruff preventing effect were observed compared to Example 1, in which the pericarp extract of the present invention, Jasperia japonica extract, and three components of DADA or GABA were simultaneously blended. As shown in Table 4, hair nourishing cosmetics Nos. 13 to 24 of the present invention showed clearly good results in all of the various tests conducted.

(Effect of the invention)

Claims (1)

[Claims] A hair nourishing product characterized by containing an extract obtained from the pericarp of Randium domesticum jackbarduke or Randium domesticum jackburansa, a Japanese japonica extract, and diisopropylamine dichloroacetate or γ-aminobutyric acid. Cosmetics.