KR20030062605A - Hair growth compositions using natural fermentation extract of herbs - Google Patents

Abstract

PURPOSE: A composition containing a fermentation extract of a natural product which protects an androgen receptor while reducing production of DHT by protecting the activity of 5-alpha-reductase is provided. The composition containing the fermentation extract helps and stimulates hair growth and causes no adverse effects to the scalp. CONSTITUTION: A composition for stimulating hair growth contains 0.1 to 10.0% by weight of a fermentation extract of sorghum and grape seeds, and vitamin B7 as an effective component. The composition further contains one or more vitamins selected from the vitamin B group consisting of vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6 and vitamin B9 or vitamin precursors and one or more fermentation extracts of a coconut fruit, barley or wheat, and a lemon.

Description

Hair Loss Prevention, Anti-Dandruff and Hair Growth Composition Containing Natural Fermented Extracts {HAIR GROWTH COMPOSITIONS USING NATURAL FERMENTATION EXTRACT OF HERBS}

The present invention relates to hair loss prevention, dandruff prevention and hair growth, and to hair loss prevention, dandruff prevention and hair growth using natural fermentation extracts and vitamins of plants as an active ingredient instead of extracts by conventional solvent extraction.

[Prior art]

Most of human hair is keratin protein which contains a lot of cystine. It is composed of 18 kinds of amino acid, melanin pigment, lipid, trace element, moisture, etc. It is made by changing the stratum corneum of skin surface like nail. It is divided into the hair shaft (Hair Shaft) and the hair root (Hair Root) inside the skin. The inflated part under the hair root is called the hair bulb, and the part that is spherical in the central part of the hair ball is called dermal papilla. The outermost layer of the scalp surface is a hard, scaly protective layer. The structure that supports the hair determines the color and shape of the hair, and the lower layer nourishes hair growth.

Hair follicles occur at 9 weeks to 4 months of fetus and initially occur at equal intervals, but with the development of the body, the skin is elongated and the density difference occurs according to each part. The first appearance of the embryonic hair (Lanugo Hair) occurs during the eighth month of birth, and is born with the hairs replaced by slightly thicker hairs (Vellus Hair) up to about 2 centimeters, and after the hair follicle growth, During puberty, hair loss occurs when the testosterone, a male hormone, is affected, and both males and females are exposed to dihydrotestosterone (DHT), a byproduct of testosterone, a male hormone.

Hair loss is caused by age, race, season, genetic factors, excessive release of male hormones, seborrheic skin, stress, diet, hair pollution, air pollution, drug use, and various diseases. Is known to be related to hereditary and hormonal factors. The symptoms are classified into scalp disease, male baldness, alopecia areata, resting hair loss, and growing hair loss.

DHT is made in both the male and female bodies, and the hormone gradually shrinks the hair follicles, making the hair thinner and very small, eventually losing hair forever, and this hair loss phenomenon is known as male / female hair loss or male hormonal hair loss.

For women, the female hormone (Estrogen) and the antibody hormone Progesterone protect hair follicles from the destructive function of DHT, resulting in fewer hair loss than men, but many women have altered levels of the hormone Female hair loss develops as the hair grows thinner due to increased and older age or the instability of female hormone levels before and after menopause.

Propecia, currently on the market using the above principles, was first orally approved by the US Food and Drug Administration (FDA) for the first time in the second half of 1997 to treat male alopecia, targeting males aged 18 to 41 with male alopecia. As a result, daily doses of propecia for up to two years resulted in an increase or retention of hair in both governments in 83% of men who took it. In addition, the placebo control group maintained and increased about 28% and the initial rate of hair loss slowed down around 3 months.

In addition, 66% of men who took the clinical picture showed remarkable regrowth of hair.

However, at the time of administration, 1) the drug was effective and when the drug was discontinued, hair loss progressed again with the non-administrator a few months later. 2) Side effects include sexual dysfunction such as loss of energy, erectile dysfunction, or ejaculation, and 3) prohibition of use in women who are pregnant or likely to become pregnant. 4) And those who have abnormal liver function must take in consultation with their doctor. Minoxidil is applied as a medicine to treat young, oily, and There is some effect (25%), but the effect is not so good in other areas.

This composition fully reflects the existing technical limitations and reduces the production of DHT by preventing the activity of 5-alpha-reductase enzyme without side effects by using natural fermented extract, while the fatty acids and vitamins of plants block the androgen receptors. It aims to provide hair loss prevention, dandruff prevention and hair growth composition that can be used to treat hair loss by promoting hair growth and smoothing metabolism of hair by cell regeneration.

In order to overcome the existing technical limitations, the present invention provides a hair growth composition that can be used by both men and women without side effects and safe by using the natural fermentation extract while helping and promoting hair growth using a natural fermentation method.

[Configuration]

The composition of the present invention provides a hair growth composition comprising i) sorghum and grape seed fermented extract, ii) vitamin B7 as an active ingredient. The composition is one or more of vitamin B group consisting of vitamin B1, vitamin B2 (Riboflabin), vitamin B3 (Nicotinic Acid), vitamin B5 (Pantothenic Acid), vitamin B6 (Pyridoxine), and vitamin B9 (Folic Acid). May contain selected vitamins or precursors, and iii) further contain one or more selected vitamins or vitamin precursors from the group of vitamins consisting of vitamin C (ascorbic acid) or vitamin C derivatives, vitamin D and vitamin E; ) May also contain one or more extracts selected from the group consisting of coconut fermented extract, barley or wheat fermented extract and lemon fermented extract.

The composition of the present invention to achieve the above object.

Iii) sorghum and grape seed fermented extracts,

Ii) vitamin B7

It provides a hair loss prevention, anti-dandruff and hair growth composition comprising a.

The fermented sorghum extract and the grape seed fermentation extract are ideally fermented extract prepared by fermenting 50 parts by weight of sorghum and 50 parts by weight of grape seed for 2 weeks, and extracting it with 100 parts by weight of solvent in anhydrous ethanol.

[Action]

Hereinafter, the action of the composition of the present invention in detail,

The present invention aims at synergistic effect of hair growth when using natural fermented extract of sorghum and grape seed obtained after fermentation. In addition, according to interactions with various vitamins and vitamin precursors and various plant fermentation extracts, natural fermentation extracts can be used rather than using conventional solvent extracts to promote hair growth.

수) sorghum and grape seed fermentation extracts used as fermentation extracts in this composition are extracted after fermentation to more effectively inhibit 5-AlPha-Reductase through promoting hair growth and unsaturated fatty acids in the epithelial cells of the scalp. Most effective at 1.0-10.0 wt%.

Vitamin B7 (Inocitol) used in the composition is a vitamin present in many fruits, cereals, vegetables, nuts, and soybeans. It enhances the function of cell membranes to prevent stimuli from the outside and enhances the activity of enzymes. It is known that hair loss occurs because hair loss is inhibited when it is an essential vitamin. The content of inositol is preferably 0.001 to 0.005% by weight, and outside the range of 0.001 to 0.005% by weight, there is no significant effect on the hair growth.

In addition, synergistic effect on hair growth may be obtained by including 5.0-20.0 wt% of at least one selected fermentation extract of coconut berry fermentation extract, barley or wheat fermentation extract, and lemon fermentation extract in the present composition. Palm fruit fermented extract, used to achieve synergistic effects of hair growth, has been extensively studied for the treatment of the enlarged prostate gland in men over the past few years. It effectively prevents male hormones and prevents DHT and also the androgen receptors found in hair follicles. It is known to prevent and can increase the hair growth effect with unsaturated fatty acids in barley or wheat.

Vitamins that can produce synergistic effects on the hair growth composition include vitamin B1, vitamin B2 (Riboflabin), vitamin B3 (Nicotinic Acid), vitamin B5 (Pantothenic Acid), vitamin B6 (Pyridoxine), and vitamin B9 (Folic Acid) At least one vitamin or vitamin selected from the group consisting of vitamin B and at least one vitamin or vitamin selected from the group consisting of vitamin C (Ascorbic Acid) or vitamin C derivatives, vitamin D and vitamin E It is spherical and can be used one or more to obtain hair growth synergy.

Looking at the efficacy of the vitamin is as follows.

Vitamin B1: Thiamine (Thiamine) is contained in uncooked grains, meat, beans, etc. It is an essential coenzyme for energy generation from sugars, which is involved in sugar metabolism to help cells grow.

Vitamin B2: Also known as vitamin G, helps cells grow and regenerate, helps maintain healthy skin and hair, and promotes metabolism.

Vitamin B3: Called niacin, it functions as a component of the coenzymes NAD and NADP in the body. These coenzymes are involved in 50 different chemical reactions in the body. Enzymes containing niacin play an important role in energy production

That is, they are involved in the production of many human compounds, including fat and cholesterol, carbohydrate metabolism, sex hormones and adrenal hormones.

Vitamin B5: Panthenol or pantonenic acid can help cure inflammation and cuts.

Vitamin B6: Improves the synthesis and activity of insulin, and vitamin B6 deficiency in the metabolism of tryptophan, which is rich in animal proteins, produces xanturenic acid, which inhibits the action of insulin. In addition, it promotes the production of binding agents, enzymes, nucleic acids, and immune substances and is an essential factor in maintaining skin and nerve function.

Vitamin B9: Also known as folic acid, is a common vitamin in women. It is recognized as one of the world's most deficient vitamins, and research shows that folate latent deficiency is widespread in certain groups, especially pregnant women, low-income people and the elderly. Folic acid aids protein metabolism and synthesis of nucleic acids. It is involved in the production of red blood cells and prevents pernicious anemia. It has also been shown to help the synthesis of DNA and RNA as an integral part of cell proliferation.

Vitamin C: The main function of vitamin C is to form collagen, the body's primary protein. Specifically, vitamin C helps a portion of the amino acid proline molecules combine to form hydroxyproline. This results in very stable collagen tissue. Collagen is an important protein for the tissues that connect the body (connective tissue, cartilage, muscles, etc.), so vitamin C is essential for healing wounds and preventing healthy gums and easy bruising.

Vitamin D: Promotes the absorption of calcium and phosphorus, binds phosphate in tissues with calcium, deposits it in the bone, smoothes the parathyroid gland's ability to regulate calcium accumulation in the blood, and also helps the thyroid gland function. It also enters the nucleus of the cell, activates RNA synthesis, and promotes cell division.

Vitamin E: Vitamin E acts primarily as an antioxidant in the body to prevent damage to cell membranes. Vitamin E also prevents the destruction by oxygen of many sensitive compounds in the body. Among the antioxidant functions of vitamin E is its ability to maintain the quality and integrity of red blood cells while helping to resist the destruction of red blood cells in the blood. Vitamin E helps the activity of vidamine A and unsaturated fatty acids. Vitamin E is needed in relatively large amounts when new cells are formed, and is very much needed during pregnancy, developmental growth, and adolescence. It is also necessary for sexual activity, women's menopause, old age.

Vitamin E prolongs youth and prolongs lifespan.

[Example]

Among the raw materials used in this embodiment, sorghum, grape seeds, barley or wheat are domestically produced products and sorghum and barley or wheat are used without being milled. Lemons were harvested from California, USA. Palm trees were made from Malaysian acid, and the fruit was split and then used to remove palm leaves.

Example 1

[Manufacture of Sorghum and Grape Seed Fermented Extracts]

500 grams (sorghum: 50% by weight, 50% by weight of grape seeds) obtained by crushing washed and dried sorghum and grape seeds were mixed well to block air at room temperature, fermented for 2 weeks, and anhydrous ethanol (99.9%) 0.5 weeks later. Soak in liters for 2 weeks.

The mixture was filtered using a 600 mesh filter, concentrated by evaporation under reduced pressure at room temperature for 6 hours, and stored in a dryer to obtain 20 grams.

Example 2

[Manufacture of Barley or Wheat Fermented Extract]

500 grams obtained by crushing washed and dried barley or wheat well are cut off from air at room temperature, fermented for 2 weeks, and after 2 weeks, soaked in 0.5 liters of anhydrous ethanol (99.9%) for 2 weeks.

The mixture was filtered using a 600 Mesh filter, concentrated by evaporation under reduced pressure at room temperature for 6 hours, and stored in a dryer to obtain 12 grams.

Example 3

[Manufacture of Palm Fruit Fermented Extract]

After washing and drying the palm tree from which palm trees were removed, it was dried well and 500 grams obtained by cutting off air at room temperature, fermented for 2 weeks, and soaked for 2 weeks in 0.5 liter of anhydrous ethanol (99.9%) after 2 weeks.

The mixture was filtered using a 600 mesh filter, concentrated by evaporation under reduced pressure at room temperature for 6 hours, and stored in a dryer to obtain 18 grams.

Example 4

[Manufacture of Lemon Fermented Extract]

500 grams of the washed and dried lemons are crushed well, air-blocked at room temperature, fermented for 2 weeks, and after 2 weeks, soaked in 0.5 liters of anhydrous ethanol (99.9%) for 2 weeks.

The mixture was filtered using a 600 mesh filter, concentrated by evaporation under reduced pressure at room temperature for 6 hours, and stored in a dryer to obtain 9 grams.

Example 5

(Hair Growth Composition of Spray Formulation)

Hair growth compositions were prepared by mixing as shown in the table below in a general spray manufacturing method.

Example 6

(Hair Growth Composition of Essence Formulation)

The hair growth composition was prepared by mixing the general essence manufacturing method as shown in the table below.

Example 7

(Hair growth composition of lotion formulation)

The hair growth composition was prepared by mixing as a general lotion manufacturing method as shown in the table below.

Example 8

(Hair Growth Composition of Cream Type)

The hair growth composition was prepared by mixing the general cream as shown in the table below.

[Clinical experiment]

This clinical trial was conducted in Ansan, Gyeonggi-do, Korea. This study was conducted on 60 patients who had not used any other products, had never received hormonal treatment in hospital dermatology, or had stopped using or treating other products or hospitals. Was carried out.

Thirty of the 60 subjects were treated as treatment groups and the other 30 as controls. The clinical trials were carried out with a spray formulation and then sprayed twice daily in the morning and evening for 16 weeks.

Tables 5 and 6 below provide information on test samples and clinical trial results after 16 weeks.

The hair growth effects in Table 6 were divided into large, normal, and minimum, and clinical trials were carried out.

Large amount: Hair regrown with full virgin hair on the bald area can be visually identified

Normal: The hair can be visually confirmed as regrowth, as the hair is black with black hair on the bald area.

Minimal: Partial hair loss can be visually confirmed by hair regrowth.

No response: Almost no hair at the hair loss site grows

As shown in the results of the clinical experiment of Table 6, the composition of the present invention was found to provide a hair growth composition while using natural fermentation extract without side effects and at the same time assisting and promoting hair growth.

The present composition provides a hair growth composition that can be used by both men and women without side effects and safe by using the natural fermentation extract while helping and promoting hair growth using a natural fermentation method to overcome the existing technical limitations.

Claims (6)

Iii) sorghum and grape seed fermented extract, ii) a hair growth composition comprising vitamin B7 as an active ingredient. According to claim 1, i) from vitamin B group consisting of vitamin B1, vitamin B2 (Riboflabin), vitamin B3 (Nicotinic Acid), vitamin B5 (Pantothenic Acid), vitamin B6 (Pyridoxine), and vitamin B9 (Folic Acid). Hair growth composition containing at least one selected vitamin or precursor In the claims 1 and 2 iii) hair growth composition containing at least one extract selected from the group consisting of coconut fermented extract, barley or wheat fermented extract and lemon fermented extract The hair growth composition of claims 1, 2 and 3 wherein the hair growth composition is a spray, essence, lotion, cream. Iii) Hair growth composition wherein the sorghum and grape seed fermented extracts are 0.1-10.0 wt% in the composition. Iii) a hair growth composition in which the coconut fruit fermentation extract, barley or wheat fermentation extract and lemon fermentation extract are 5.0-10.0% by weight in the composition