A kind of composition and its application with moistening effect
Technical field
The present invention relates to a kind of composition, especially a kind of composition and its application with moistening effect.
Background technology
Moisturizing Journal of Sex Research is current cosmetics and the hot spot of dermatology research.Environmental pollution, Seasonal conversion so that because of angle
Dry skin caused by matter break water and the skin problem that thus caused skin is itched, furfur etc. is common are more and more tighter
Weight, moisturizing are very urgent.Moisturizer is added in cosmetics, it is therefore intended that the water content of keratoderma is maintained or increases, with
Phase, which improves, solves these common skin problems.Moisturizer can be divided into natural moisture preserving agent and synthesis moisturizer by its source, wherein
Natural moisture preserving agent can effectively prevent skin allergy, the phenomenon of the infringement skin such as erythema occurs, therefore natural moisture preserving agent is increasingly
Favored be subject to consumer.
The content of the invention
Based on this, provided a kind of with moisturizing effect it is an object of the invention to overcome above-mentioned the deficiencies in the prior art part
The composition of fruit.
To achieve the above object, the technical solution used in the present invention is:A kind of composition with moistening effect, comprising
Phosphatidylcholine Hydrogenated and active matter, the active matter is water, the mixing of the compounding of lecithin, ethanol, tocopherol, sodium hydroxide
Thing.
Preferably, the active matter is Natipide II.
Preferably, the Phosphatidylcholine Hydrogenated is 0.1~0.3 parts by weight, and the active matter is 6~7 parts by weight.
In the present composition, Phosphatidylcholine Hydrogenated (PHOSPHOLIPON 90H) is the natural lecithin by soybean-source
Fat hydrogenation saturation forms.Lecithin is cell membrane and various organelles (mitochondria, endoplasmic reticulum, nucleus, Golgi's organs, Ye Lv
Body etc.) film important component, almost whole lecithin contained by cell all concentrate in biomembrane.Many spies of biomembrane
Property, such as permeability barrier as material inside and outside film, the exchange of material inside and outside film, information transmission, the conduction of nerve impulse etc. is all
It is related with lecithin and other film fat.
Phosphatidylcholine Hydrogenated is a kind of effective skin sense modifying agent, the not only lipophilic but also close of the phosphatidyl choline inside lecithin
Water, obtained product product have unique soft comfortable skin sense.
Phosphatidylcholine Hydrogenated or a kind of penetration enhancers, the chemical constituent of lecithin and the cell membrane component of human body connect
Closely, there is excellent compatibility with skin, therefore as the delivery vehicles of material inside and outside film active ingredient can be allowed to infiltrate through skin easily
In skin.Lecithin can also form liposome under certain condition, have more preferably parcel protection to active matter with helping the effect of oozing.
Phosphatidylcholine Hydrogenated can also rebuild skin natural moisture barrier, and healthy cuticula is skin natural moisture preserving screen
Barrier, lecithin is the indispensable material of corneocyte, if lacked, will reduce the power of regeneration of Skin Cell, cause
The problems such as pachylosis, wrinkle.The appropriate supplement required lecithin of skin, then viability are ensured, moreover it is possible to protect skin
Damaged from environmental stimuli.Lecithin has superpower hydration properties, and a phospholipid molecule can be hydrated 23 hydrones, be exhausted
Good natural moisture preserving agent.
In addition, Phosphatidylcholine Hydrogenated can effectively help absorption of the skin to active matter and moisture content, the full of skin is lifted
Degree and moisture feeling, and prolonged moistening effect can be maintained.
Active matter of the present invention, can slowly release wrapped up active ingredient, extend work of the active ingredient to skin
With the time, promote absorption of the skin to active ingredient.In addition, it also effectively supplements the required phosphatide of skin, improve skin day
Right moisture barrier, plays good skin-moisturizing, skin effect, also there is very excellent moisturizing effect.
Natipide II are mixed with the aqueous active thing that need to be wrapped up, moderate-speed mixer is uniform.Then add extra
Moisture content, low speed homogeneous is to uniformly can having been wrapped up the liposome of active matter.It the experiment proved that, its parcel to active matter
Rate can reach 15%~50%.Specific parcel amount and the characteristic of various active matters, the design for stirring dynamics and formula are related.Generally
Empirical value is that the dosage of Natipide II should be 4 to 7 times of active matter.
The liposome that Natipide II are formed, resistant to shearing can pipeline.It can be stably dispersed in aqueous phase substrate, shape
Into opaque suspension.It can also be stable in the presence of the stability without influencing lotion in cream matrix.
It is highly preferred that the composition with moistening effect, the hyaluronic acid of 0.01~0.03 parts by weight is also included
Sodium.
It is highly preferred that the weight ratio of the Phosphatidylcholine Hydrogenated, active matter, Sodium Hyaluronate is:Hydrogenated phospholipid acyl courage
Alkali:Active matter:Sodium Hyaluronate=2:65:0.2.
The component compounding of above-mentioned three kinds of biologically active high moisturizings, can play the effect of synergy, reach non-
The moistening effect of Chang Youyi.
Preferably, the composition with moistening effect, also includes the moisturizer of following parts by weight:1,3- propane diols
3~5 parts, 1~3 part of trehalose.
Preferably, the composition with moistening effect, also includes the component of following parts by weight:Deionized water 80~
90 parts, 0.1~0.2 part of carbomer, 0.04~0.06 part of chelating agent, 0.1~0.2 part of neutralizer, 0.7~0.9 part of preservative.
Preferably, the chelating agent is EDETATE SODIUM, and the preservative is decoyl hydroximic acid, the compounding of 1.3- propane diols is mixed
Compound.
Meanwhile the present invention also provides a kind of skin care item for including the composition.The skin care item have preferable moisturizing
Effect.
Preferably, the skin care item are facial mask.
Relative to the prior art, beneficial effects of the present invention are:
Component (Natipide II, hyaluronic acid of the composition of the present invention containing three kinds of biologically active high moisturizings
Sodium, PHOSPHOLIPON 90H), by synergistic effect, there is very excellent moistening effect.Wherein, unique ovum
Phosphatide moisturizing effect;Unique lecithin adipose membrane is formed, sturdy skin is soft fine and smooth;Absorb faster;Promote active matter by skin
Skin absorbs, and plays the role of a carrier.
Brief description of the drawings
Fig. 1 is the moisturizing design sketch for applying 2.0%Natipide II aqueous solutions on the skin;
Fig. 2 is the change of different periods skin moisture content.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with the drawings and specific embodiments pair
The present invention is described further.Phosphatidylcholine Hydrogenated of the present invention and the commercially available gained of active matter, such as can purchase in wide
Zhou Cheng will trade Co., Ltd.
Embodiment 1
A kind of embodiment of the present invention with moistening effect composition, composition described in the present embodiment include following heavy
Measure the component of part:
0.2 part of Phosphatidylcholine Hydrogenated (PHOSPHOLIPON 90H), 6.5 parts of active matter, 0.02 part of Sodium Hyaluronate, 1,
4 parts of ammediol, 2 parts of trehalose, 86.2 parts of deionized water, 0.15 part of carbomer, 0.05 part of chelating agent (EDETATE SODIUM), neutralization
0.15 part of agent, 0.8 part of preservative (the compounding mixture of decoyl hydroximic acid and 1.3- propane diols), the active matter is water, lecithin
Fat, ethanol, tocopherol, the compounding mixture of sodium hydroxide, such as Natipide II.
A kind of skin care item for including above-mentioned composition, the skin care item are facial mask.
Embodiment 2
A kind of embodiment of the present invention with moistening effect composition, composition described in the present embodiment include following heavy
Measure the component of part:
0.1 part of Phosphatidylcholine Hydrogenated (PHOSPHOLIPON 90H), 6 parts of active matter, 0.01 part of Sodium Hyaluronate, 1,3-
3 parts of propane diols, 1 part of trehalose, 80 parts of deionized water, 0.1 part of carbomer, 0.04 part of chelating agent (EDETATE SODIUM), neutralizer 0.1
Part, 0.7 part of preservative (the compounding mixture of decoyl hydroximic acid and 1.3- propane diols), the active matter is water, lecithin, second
Alcohol, tocopherol, the compounding mixture of sodium hydroxide, such as Natipide II.
A kind of skin care item for including above-mentioned composition, the skin care item are facial mask.
Embodiment 3
A kind of embodiment of the present invention with moistening effect composition, composition described in the present embodiment include following heavy
Measure the component of part:
0.3 part of Phosphatidylcholine Hydrogenated (PHOSPHOLIPON 90H), 7 parts of active matter, 0.03 part of Sodium Hyaluronate, 1,3-
5 parts of propane diols, 3 parts of trehalose, 90 parts of deionized water, 0.2 part of carbomer, 0.06 part of chelating agent (EDETATE SODIUM), neutralizer 0.2
Part, 0.9 part of preservative (the compounding mixture of decoyl hydroximic acid and 1.3- propane diols), the active matter is water, lecithin, second
Alcohol, tocopherol, the compounding mixture of sodium hydroxide, such as Natipide II.
A kind of skin care item for including above-mentioned composition, the skin care item are facial mask.
Embodiment 4
Moistening effect is verified
The present embodiment researchs and analyses the prepared moistening effect for obtaining facial mask in embodiment 1~3, experimental method
For:20-40 Sui women of age totally 60 people is chosen, is randomly divided into 3 groups, every group of 20 people.By experimenter respectively using embodiment 1~
3 facial mask, every night using once, are used continuously one month, trial employment period volunteer is without using other skin care item.Pin respectively
To six sampled data points of volunteer face, i.e., left front volume, right forehead, left face, right face, lower-left bar, bottom right bar, measures and records
The moisture content at sample strong point, each sampling are surveyed 3 times, are averaged as final result.
Test method:In 20 DEG C, the indoor environment of relative humidity 50%, surveyed with CorneometerCM820 moisture of skin
The water content test that instrument carries out six sampled data points skins of every group of 20 female consumers skin is measured, its result is by setting
Fixed humidity measurements (Moisture Measurement Value, MMV) represent, final MMV values are to average
As a result represent, to evaluate the replenishing water and preserving moisture performance of the product, wherein:MMV1 --- the skin MMV values before spread product,
MMV2 --- the skin MMV values after spread product in 15 minutes, skin MMV values after 1 hour of MMV3 --- spread product;Moisturizing
Rate=MMV2/MMV1 × 100%;Moisturizing rate=MMV3/MMV2 × 100%.Specific test result is as shown in table 1:
1 performance of keeping humidity test result of table
Group |
Make-up water percentage, % |
Moisturizing rate, % |
Experimental group 1 |
278 |
97 |
Experimental group 2 |
265 |
86 |
Experimental group 3 |
268 |
87 |
As it can be seen from table 1 the facial mask in the embodiment of the present invention 1~3 is respectively provided with preferable moisturizing moisturizing performance, wherein,
Moisturizing moisturizing effect in embodiment 1 is best.
Embodiment 5
Test and be divided into control group and experimental group, prepared facial mask in the respectively embodiment 1~3 of experimental group 1~3, control group
Be divided into 6 groups, in the facial mask of control group 1~6 contained component except Phosphatidylcholine Hydrogenated, active matter, three kinds of Sodium Hyaluronate into
Point content it is different outer, other compositions are same as Example 1, in addition, in every group of experiment, Phosphatidylcholine Hydrogenated, active matter,
Total content of the Sodium Hyaluronate three in facial mask is identical, and simply the ratio of three is different, hydrogen in specific control group 1~6
It is as shown in table 2 to change phosphatidyl choline, active matter, the parts by weight content of three kinds of components of Sodium Hyaluronate:
Phosphatidylcholine Hydrogenated, active matter, the weight ratio of three kinds of components of Sodium Hyaluronate in 2 control group facial mask of table
Group |
1 |
2 |
3 |
4 |
5 |
6 |
Phosphatidylcholine Hydrogenated |
2 |
0 |
0 |
0 |
2 |
2 |
Active matter |
0 |
65 |
0 |
65 |
65 |
0 |
Sodium Hyaluronate |
0 |
0 |
0.2 |
0.2 |
0 |
0.2 |
In control group and experimental group, choose 20 ages for every group and carry out research on probation in the volunteer of 20~50 years old, it is real
The facial mask that the subjects of group 1~3 are prepared using embodiment 1~3 respectively is tested, the subjects of control group 1~6 make respectively
The facial mask being prepared with control group 1~6, skin care item application method as in embodiment 4, are more than if measuring make-up water percentage
260%, and moisturizing rate is more than 80%, is considered as effectively, statistics is efficient, and the results are shown in Table 3.
The effective situation statistical result of moisturizing in 3 experimental group of table and control group
As seen from Table 3, Phosphatidylcholine Hydrogenated, active matter, Sodium Hyaluronate are comprised only in the facial mask of control group 1~6
One kind in three kinds of components, two kinds, without good moistening effect.And the facial mask of experimental group 1~3 contains three kinds of components, tool
There is good moistening effect.Thus it is provable, in facial mask of the invention, Phosphatidylcholine Hydrogenated, active matter, Sodium Hyaluronate three
Kind component has the function that to mutually promote, mutually cooperates with, and can play significant moistening effect.
Embodiment 6
The present embodiment carries out test analysis to the long-acting moistening effect of Natipide II, and specific test process is:
Volunteer:10 people;Using:Single Natipide II aqueous solutions are applied to skin;
Frequency:Twice daily;Cycle:28 days
Dosage:1.2mg PL/CM2Skin (about 2%Natipide II aqueous solutions)
Test number:Skin measured moisture content increase changing value, test result after 30 minutes of liposome aqueous solution are smeared
As shown in Figure 1:
As can be seen from Figure 1:(1):It is continuous to smear the aqueous solution containing quantitative Natipide II, obtained moisturizing at the 7th day
Maximum;During continuous use in (2) 7 days to 28 days, moisturizing effect can maintain high level;Maximum can be obtained again within (3) the 28th days;
(4) stop using after 2.0%Natipide II aqueous solutions in two days, skin still keeps good moistening effect.
Embodiment 7
The present embodiment researchs and analyses the performance of keeping humidity of PHOSPHOLIPON 90H, and specific research process is:
Tester:The facial mask of the 90H containing 0.1%PHOSPHOLIPON, blank control facial mask;
Test object:6 volunteers, age 24-42 Sui, men and women is fifty-fifty;
Test equipment:Moisture of skin oil test pen;
Testing procedure:
1st, be directed to six sampled data points of volunteer face respectively, i.e., left front volume, right forehead, left face, right face, lower-left bar,
Bottom right bar, measures and records the moisture content at sample strong point.
2nd, contrast mask sheet is applied at the same time respectively in the right and left face of volunteer.
3rd, tear after 15 minutes facial mask.
4th, reading is carried out to six sampled data points after ten minutes and recorded.
5th, reading is carried out to six sampled data points again after 30 minutes and recorded.
Test data arranges:Three readings of the right and left each time are respectively averaged, compares different periods skin and contains
The change of water rate, as shown in Figure 2:
Interpretation of result:(1) after having applied facial mask, PHOSPHOLIPON 90H can substantially increase skin part moisture content moisture content.(2) take off
30 minutes after lower facial mask, it can also continue to the good moistening effect of skin.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, those of ordinary skill in the art should
Understand, can be to technical scheme technical scheme is modified or replaced equivalently, without departing from the essence of technical solution of the present invention
And scope.