A kind of composition and its application with moistening effect
Technical field
The present invention relates to a kind of composition, especially a kind of composition and its application with moistening effect.
Background technique
Moisturizing Journal of Sex Research is the hot spot of current cosmetics and dermatology research.Environmental pollution, Seasonal conversion, so that because of angle
Dry skin caused by matter break water and thus caused by skin is itched, furfur etc. is common skin problem it is more and more tighter
Weight, moisturizing are very urgent.Moisturizer is added in cosmetics, it is therefore intended that the water content of keratoderma is maintained or increases, with
Phase, which improves, solves these common skin problems.Moisturizer can be divided into natural moisturizer and synthesis moisturizer by its source, wherein
The damage skin the phenomenon that, such as skin allergy can be effectively prevented, erythema occurs in natural moisturizer, therefore natural moisturizer is increasingly
Favor by consumer.
Summary of the invention
Based on this, provided a kind of with moisturizing effect it is an object of the invention to overcome above-mentioned the deficiencies in the prior art place
The composition of fruit.
To achieve the above object, the technical solution used in the present invention are as follows: a kind of composition with moistening effect includes
Phosphatidylcholine Hydrogenated and active matter, the active matter are the compounding mixing of water, lecithin, ethyl alcohol, tocopherol, sodium hydroxide
Object.
Preferably, the active matter is Natipide II.
Preferably, the Phosphatidylcholine Hydrogenated is 0.1~0.3 parts by weight, and the active matter is 6~7 parts by weight.
In the present composition, Phosphatidylcholine Hydrogenated (PHOSPHOLIPON 90H) is the natural lecithin by soybean-source
Rouge adds hydrogen to be saturated.Lecithin is cell membrane and various organelles (mitochondria, endoplasmic reticulum, nucleus, Golgi's organs, Ye Lv
Body etc.) film important component, almost whole lecithin contained by cell all concentrate in biomembrane.Many spies of biomembrane
Property, such as permeability barrier as substance inside and outside film, the exchange of substance inside and outside film, information transmits, and conduction of nerve impulse etc. is all
It is related with lecithin and other film rouge.
Phosphatidylcholine Hydrogenated is a kind of effective skin sense modifying agent, the not only lipophilic but also close of the phosphatidyl choline inside lecithin
Water, the skin sense that obtained product product have unique softness comfortable.
Phosphatidylcholine Hydrogenated or a kind of penetration enhancers, the chemical constituent of lecithin and the cell membrane component of human body connect
Closely, there is excellent compatibility with skin, therefore can be used as the delivery vehicles of substance inside and outside film, active constituent is allowed to infiltrate through skin easily
In skin.Lecithin can also form liposome under certain condition, have more preferably package protection to act on infiltration is helped active matter.
Phosphatidylcholine Hydrogenated can also rebuild skin natural moisture barrier, and healthy cuticula is skin natural moisture preserving screen
Barrier, lecithin is the indispensable substance of corneocyte, if lacked, will reduce the power of regeneration of Skin Cell, cause
The problems such as pachylosis, wrinkle.Lecithin required for appropriate supplement skin, then viability are ensured, moreover it is possible to protect skin
It is damaged from environmental stimuli.Lecithin hydration properties with super strength, a phospholipid molecule can be hydrated 23 hydrones, be exhausted
Good natural moisturizer.
In addition, Phosphatidylcholine Hydrogenated can effectively help skin to the absorption of active matter and moisture content, the full of skin is promoted
Degree and moisture feeling, and prolonged moistening effect can be maintained.
Active matter of the present invention can slowly release wrapped up active constituent, extend active constituent to the work of skin
With the time, promote absorption of the skin to active ingredient.In addition, it also effectively supplements phosphatide required for skin, improve skin day
Right moisture barrier plays good skin-moisturizing, skin effect, also there is very excellent moisturizing effect.
Natipide II is mixed with the aqueous active object that need to be wrapped up, moderate-speed mixer is uniform.Then it is added additional
Moisture content, low speed homogeneous wrapped up the liposome of active matter to uniformly can be obtained.The experiment proved that its package to active matter
Rate can reach 15%~50%.The characteristic of specific package amount and various active matters, the design for stirring dynamics and formula are related.Generally
Empirical value is that the dosage of Natipide II should be 4 to 7 times of active matter.
The liposome that Natipide II is formed, resistant to shearing can pipeline.It can be stably dispersed in aqueous phase substrate, shape
At opaque suspension.It can also be stable in the presence of the stability in cream matrix without will affect lotion.
It is highly preferred that the composition with moistening effect, also includes the hyaluronic acid of 0.01~0.03 parts by weight
Sodium.
It is highly preferred that the weight ratio of the Phosphatidylcholine Hydrogenated, active matter, Sodium Hyaluronate are as follows: hydrogenated phospholipid acyl gallbladder
Alkali: active matter: Sodium Hyaluronate=2:65:0.2.
The ingredient of above-mentioned three kinds of biologically active high moisturizings compounds, and can play synergistic effect, reach non-
The moistening effect of Chang Youyi.
Preferably, the composition with moistening effect also includes the moisturizer of following parts by weight: 1,3-PD
3~5 parts, 1~3 part of trehalose.
Preferably, the composition with moistening effect also includes the ingredient of following parts by weight: deionized water 80~
90 parts, 0.1~0.2 part of carbomer, 0.04~0.06 part of chelating agent, 0.1~0.2 part of neutralizer, 0.7~0.9 part of preservative.
Preferably, the chelating agent is EDETATE SODIUM, and the preservative is decoyl hydroximic acid, the compounding of 1.3- propylene glycol is mixed
Close object.
Meanwhile the present invention also provides a kind of skin care item comprising the composition.The skin care item have preferable moisturizing
Effect.
Preferably, the skin care item are facial mask.
Compared with the existing technology, the invention has the benefit that
Composition of the invention contains ingredient (Natipide II, hyaluronic acid of three kinds of biologically active high moisturizings
Sodium, PHOSPHOLIPON 90H), by synergistic effect, there is very excellent moistening effect.Wherein, unique ovum
Phosphatide moisturizing effect;Unique lecithin adipose membrane is formed, sturdy skin is soft fine and smooth;It absorbs faster;Promote active matter by skin
Skin absorbs, and plays the role of a carrier.
Detailed description of the invention
Fig. 1 is the moisturizing effect picture for applying 2.0%Natipide II aqueous solution on the skin;
Fig. 2 is the variation of different periods skin moisture content.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with the drawings and specific embodiments pair
The present invention is described further.Phosphatidylcholine Hydrogenated of the present invention and the commercially available gained of active matter, such as can purchase in wide
Zhou Cheng will trade Co., Ltd.
Embodiment 1
A kind of embodiment of the present invention with moistening effect composition, composition described in the present embodiment include following heavy
Measure the ingredient of part:
0.2 part of Phosphatidylcholine Hydrogenated (PHOSPHOLIPON 90H), 6.5 parts of active matter, 0.02 part of Sodium Hyaluronate, 1,
4 portions of 3-propanediol, 86.2 parts of deionized water, 0.15 part of carbomer, 0.05 part of chelating agent (EDETATE SODIUM), neutralizes 2 parts of trehalose
0.15 part of agent, 0.8 part of preservative (the compounding mixture of decoyl hydroximic acid and 1.3- propylene glycol), the active matter are water, lecithin
Rouge, ethyl alcohol, tocopherol, sodium hydroxide compounding mixture, such as Natipide II.
A kind of skin care item comprising above-mentioned composition, the skin care item are facial mask.
Embodiment 2
A kind of embodiment of the present invention with moistening effect composition, composition described in the present embodiment include following heavy
Measure the ingredient of part:
0.1 part of Phosphatidylcholine Hydrogenated (PHOSPHOLIPON 90H), 6 parts of active matter, 0.01 part of Sodium Hyaluronate, 1,3-
3 parts of propylene glycol, 1 part of trehalose, 80 parts of deionized water, 0.1 part of carbomer, 0.04 part of chelating agent (EDETATE SODIUM), neutralizer 0.1
Part, 0.7 part of preservative (the compounding mixture of decoyl hydroximic acid and 1.3- propylene glycol), the active matter are water, lecithin, second
Alcohol, tocopherol, sodium hydroxide compounding mixture, such as Natipide II.
A kind of skin care item comprising above-mentioned composition, the skin care item are facial mask.
Embodiment 3
A kind of embodiment of the present invention with moistening effect composition, composition described in the present embodiment include following heavy
Measure the ingredient of part:
0.3 part of Phosphatidylcholine Hydrogenated (PHOSPHOLIPON 90H), 7 parts of active matter, 0.03 part of Sodium Hyaluronate, 1,3-
5 parts of propylene glycol, 3 parts of trehalose, 90 parts of deionized water, 0.2 part of carbomer, 0.06 part of chelating agent (EDETATE SODIUM), neutralizer 0.2
Part, 0.9 part of preservative (the compounding mixture of decoyl hydroximic acid and 1.3- propylene glycol), the active matter are water, lecithin, second
Alcohol, tocopherol, sodium hydroxide compounding mixture, such as Natipide II.
A kind of skin care item comprising above-mentioned composition, the skin care item are facial mask.
Embodiment 4
Moistening effect verifying
The present embodiment researchs and analyses the moistening effect for obtaining facial mask prepared in Examples 1 to 3, experimental method
Are as follows: 20-40 years old age women totally 60 people is chosen, is randomly divided into 3 groups, every group of 20 people.Experimenter is used respectively embodiment 1~
3 facial mask, every night using once, are used continuously one month, and trial employment period volunteer does not use other skin care item.Needle respectively
To six sampled data points of volunteer face, i.e., left front volume, right forehead, left face, right face, lower-left bar, bottom right bar measures and records
The moisture content at sample strong point, each sampling are surveyed 3 times, are averaged as final result.
Test method: it in 20 DEG C, the indoor environment of relative humidity 50%, is surveyed with CorneometerCM820 moisture of skin
It measures the water content that instrument carries out skin to six sampled data points skins of every group of 20 female consumers to test, result is by setting
Fixed humidity measurements (Moisture Measurement Value, MMV) indicate, final MMV value is to average
As a result it indicates, to evaluate the replenishing water and preserving moisture performance of the product, in which: MMV1 --- the skin MMV value before spread product,
MMV2 --- the skin MMV value after spread product in 15 minutes, skin MMV value after 1 hour of MMV3 --- spread product;Moisturizing
Rate=MMV2/MMV1 × 100%;Moisturizing rate=MMV3/MMV2 × 100%.Specific test result is as shown in table 1:
1 performance of keeping humidity test result of table
Group |
Make-up water percentage, % |
Moisturizing rate, % |
Experimental group 1 |
278 |
97 |
Experimental group 2 |
265 |
86 |
Experimental group 3 |
268 |
87 |
As it can be seen from table 1 the facial mask in the embodiment of the present invention 1~3 all has preferable moisturizing moisturizing performance, wherein
Moisturizing moisturizing effect in embodiment 1 is best.
Embodiment 5
Test is divided into control group and experimental group, and experimental group 1~3 is respectively prepared facial mask in Examples 1 to 3, control group
Be divided into 6 groups, component contained in the facial mask of control group 1~6 except Phosphatidylcholine Hydrogenated, active matter, three kinds of Sodium Hyaluronate at
Point content it is different outer, other compositions are same as Example 1, in addition, in every group of test, Phosphatidylcholine Hydrogenated, active matter,
Total content of the Sodium Hyaluronate three in facial mask be it is identical, only the ratio of three is different, hydrogen in specific control group 1~6
It is as shown in table 2 to change phosphatidyl choline, active matter, the parts by weight content of three kinds of ingredients of Sodium Hyaluronate:
Phosphatidylcholine Hydrogenated, the weight ratio of three kinds of active matter, Sodium Hyaluronate ingredients in 2 control group facial mask of table
Group |
1 |
2 |
3 |
4 |
5 |
6 |
Phosphatidylcholine Hydrogenated |
2 |
0 |
0 |
0 |
2 |
2 |
Active matter |
0 |
65 |
0 |
65 |
65 |
0 |
Sodium Hyaluronate |
0 |
0 |
0.2 |
0.2 |
0 |
0.2 |
In control group and experimental group, chooses 20 ages for every group and in 20~50 years old volunteer carry out research on probation, it is real
The facial mask that the subjects of group 1~3 are prepared using Examples 1 to 3 respectively is tested, the subjects of control group 1~6 make respectively
The facial mask being prepared with control group 1~6, skin care item application method as in embodiment 4, are greater than if measuring make-up water percentage
260%, and moisturizing rate is greater than 80%, is considered as effectively, statistics is efficient, and the results are shown in Table 3.
The effective situation statistical result of moisturizing in 3 experimental group of table and control group
As seen from Table 3, Phosphatidylcholine Hydrogenated, active matter, Sodium Hyaluronate are contained only in the facial mask of control group 1~6
One of three kinds of ingredients, two kinds do not have good moistening effect.And the facial mask of experimental group 1~3 contains there are three types of ingredient, has
There is good moistening effect.Thus provable, in facial mask of the invention, Phosphatidylcholine Hydrogenated, active matter, Sodium Hyaluronate three
Kind ingredient has the function of mutually promoting, mutually cooperate with, and can play significant moistening effect.
Embodiment 6
The present embodiment carries out test analysis, specific test process to the long-acting moistening effect of Natipide II are as follows:
Volunteer: 10 people;Using: single Natipide II aqueous solution is applied to skin;
Frequency: twice daily;Period: 28 days
Dosage: 1.2mg PL/CM2Skin (about 2%Natipide II aqueous solution)
Test number: skin measured moisture content after smearing 30 minutes of liposome aqueous solution increases changing value, test result
As shown in Figure 1:
As can be seen from Figure 1: (1): it is continuous to smear the aqueous solution containing quantitative Natipide II, moisturizing was obtained at the 7th day
Maximum value;When continuous use in (2) 7 days to 28 days, moisturizing effect can maintain high level;Maximum value can be obtained again within (3) the 28th days;
(4) it stops using after 2.0%Natipide II aqueous solution in two days, skin still keeps good moistening effect.
Embodiment 7
The present embodiment researchs and analyses the performance of keeping humidity of PHOSPHOLIPON 90H, specific research process are as follows:
Tester: the facial mask of the 90H containing 0.1%PHOSPHOLIPON, blank control facial mask;
Test object: 6 volunteers, the age 24-42 years old, men and women was fifty-fifty;
Test equipment: moisture of skin oil test pen;
Testing procedure:
1, respectively be directed to six sampled data points of volunteer face, i.e., left front volume, right forehead, left face, right face, lower-left bar,
Bottom right bar measures and records the moisture content at sample strong point.
2, comparison mask sheet is applied simultaneously respectively in the right and left face of volunteer.
3, it tears after 15 minutes facial mask.
4, six sampled data points are read and is recorded after ten minutes.
5, six sampled data points are read and is recorded again after 30 minutes.
Test data arranges: three readings of the right and left each time being respectively averaged, compares different periods skin and contains
The variation of water rate, as shown in Fig. 2:
Interpretation of result: (1) after having applied facial mask, PHOSPHOLIPON 90H can obviously increase skin part moisture content moisture content.(2) it takes off
30 minutes after lower facial mask, it can also continue to the good moistening effect of skin.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.