KR20080038812A - A cosmetic of sheet-type containing unsoluble material stably in a low viscosity level state - Google Patents

Abstract

A sheet-type cosmetic composition is provided to increase the effect of an insoluble material to skin by improving dispersion property of the insoluble material which is unable to be stabilized in a conventional low viscous formulation and immersing the insoluble material into a sheet. A sheet-type cosmetic composition is characterized in that it includes a sheet where a low-viscous nano-emulsion containing a liposomed insoluble material is immersed, wherein the insoluble material is at least one selected from the group consisting of retinol, a retinol derivative, tocopherol, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, linoleic acid, coenzyme Q-10, resveratrol, a plant extract essential oil, ursolic acid, oleanolic acid, oil-soluble licorice root, and lipoic acid. Further, the 1 to 10 wt.% of insoluble liposome is comprised based on the 100 wt.% of cosmetic composition, and the low-viscous of the emulsion is 300 to 3000 CPS.

Description

A Cosmetic of Sheet-Type Containing Unsoluble Material Stably in a Low Viscosity Level State

Figure 1 shows the results of the comparison experiment using the impregnation solution.

Figure 2 shows the visual evaluation score for the eye wrinkles according to the use time of the sheet mask.

The present invention relates to a sheet-like cosmetics stably dispersed and containing a poorly soluble substance at low viscosity, and more particularly, using a low viscosity fluid nanoemulsion to disperse and stabilize the poorly soluble substance collected by liposomes in the sheet. It relates to sheet cosmetics.

The pack is a cosmetic formulation that provides the skin with moisture, nutrients and useful ingredients due to its temporary occlusion effect, imparts moderate tension to the skin and promotes blood circulation. As a cosmetic that has been used to improve the functions of not only the face but also the whole body skin, many types of packs have been developed and used today. Also, as interest in skin care has increased recently, the interest in packs has increased. Development of formulations is also diversified.

Packs are generally classified into wash-off and peel-off products and sheet types. Wash-off products which are washed with water are mainly differentiated according to the material, for example, mud, mung bean, charcoal, etc. to keep the skin clean. Peel-Off products, which form a film and tear off when dried, are mainly used for sebum or keratin care, and are used in whitening products or sebum pores. Recently, the Peel-Off type products have been decreasing in both domestic and foreign markets, but in the case of the Wash-Off type, various materials can be used, have a characteristic texture, and Formulations are possible, and because of the ease of overnight, various developments have been made. In addition, the proportion of sheet formulations is gradually increasing, mainly moisturizing and nutritional functions. Recently, the formulations that emphasize intensive and functional effects such as whitening and wrinkles are increasing, which is good for skin. Products that emphasize the effectiveness and high-concentration image with active substances are receiving good responses from consumers.

In the case of the sheet type, the compatibility between the sheet and the impregnated emulsion phase is important, so most of the low viscosity solubilized formulations are used as the impregnation solution. When water-soluble active substance is added, it is generally water-soluble when mixed with a solubilized liquid and impregnated into a sheet. However, when the active ingredient is poorly soluble, there is a limit to stabilization in a low-viscosity solubilized solution. In addition, the development of low viscosity sheet cosmetics that can stably contain poorly soluble substances and impregnate the sheets has been an urgent and important problem.

Therefore, the inventors of the present invention have attempted to develop a sheet cosmetic of low viscosity nanoemulsion emulsion that can stably contain a poorly soluble substance that is effective on the skin and can be impregnated into the sheet. Here, the poorly soluble substance is a substance that does not dissolve well in water or other solvents, and in the case of an effective substance having physiological activity, it is often poorly soluble. As a result, it was found that the use of such poorly water-soluble materials can be stabilized even in low viscosity formulations, thereby completing the present invention.

Therefore, an object of the present invention is to improve the dispersibility of poorly soluble substances that can not be stabilized in the existing low viscosity formulations to enable sheet impregnation while maintaining the activity of the active ingredient for a long time to increase the effect on the skin sheet-like cosmetics To provide.

In order to achieve the above object, the present invention provides a sheet-like cosmetics comprising a sheet impregnated with a low-viscosity nanoemulsion containing a liposome-formed poorly soluble material.

In the cosmetic composition of the present invention, the viscosity of the nanoemulsion is characterized in that 300 ~ 3000CPS.

In addition, in the cosmetic composition of the present invention, the nanoemulsion has a particle size of 20 to 500 nm, characterized in that the lipid component, a liquid oil, a humectant, and an aqueous thickener as a formulation skeleton component.

In addition, in the cosmetic composition of the present invention, the content of poorly soluble liposomes is preferably 1 to 10% by weight based on the total weight of the cosmetic composition.

In addition, the solid lipid component in the nanoemulsion of the present invention is 0.5 to 4.0% by weight, preferably 1.0 to 2.5% by weight relative to the total weight of the cosmetic composition in the O / W formulation. In addition, the liquid oil component is contained in the O / W formulation of 3.0 to 25.0% by weight, preferably 5.0 to 15.0% by weight relative to the total weight of the cosmetic composition, the water-based thickener is the creaming of the nano-emulsion of the particles In order to suppress the phenomenon and control the viscosity, the content thereof is a level suitable for making a formulation, and is preferably contained at a concentration of 0.05 to 0.5% by weight based on the total weight of the cosmetic composition.

Hereinafter, the present invention will be described in more detail.

The poorly water-soluble substance is not particularly limited, and for example, retinol and retinol derivatives (retinylacetate, retinyl palmitate), tocopherol, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, linoleic acid , Coenzyme Q-10, resveratrol or botanical extract essential oils, ursolic acid, oleanolic acid, oil-soluble licorice, lipoic acid, etc., these ingredients have the effect of enhancing whitening, improving wrinkles, anti-aging and antioxidant, Sheet-type cosmetics that can implement intensive and functional efficacy can be provided to consumers.

The inventors have confirmed that the low viscosity nanoemulsion formulation is the best to stabilize the liposomes containing poorly soluble materials and at the same time ensure compatibility with the sheet. Compared with solubilized formulations or general low viscosity emulsions, nanoemulsion formulations were easy to disperse liposome base stabilized poorly soluble materials and the formulation stability was the best. Specifically, in the case of a solubilized formulation, the liposome base is separated in the formulation before impregnating the sheet, resulting in poor stability, and poorly soluble substances are not evenly dispersed in the sheet. In addition, in the case of the general low viscosity emulsion, it is easier to disperse the poorly soluble substance than the solubilized formulation, but when the viscosity of the emulsion is less than 3000CPS, not only its stability is poor, but also the compatibility when the sheet is impregnated is poor. On the other hand, in the case of nanoemulsion, the poorly soluble substance was best dispersed in the sheet, and the compatibility with the sheet was excellent as well as the degree of evenly dispersing the components in the sheet.

According to the present invention, the viscosity of the nanoemulsion as an impregnation liquid in a low viscosity sheet-like cosmetic composition containing a poorly soluble substance is preferably 300 to 3000 CPS (spindle 3). If the viscosity is less than 300 CPS, the dispersion stability of the poorly soluble liposome base in the formulation is poor, and when the sheet impregnated with the emulsion is applied to the skin, the liquid flows and the usability is poor. In addition, since the viscosity is higher than 3000 CPS and compatibility with a sheet is not good, it is not suitable for application as a cosmetics wetted with a sheet.

It is preferable that the poorly soluble liposome used in the cosmetic composition of the present invention is 1 to 10% by weight based on the total weight of the cosmetic composition.

In the composition of the present invention, the solid lipid component in the nanoemulsion is contained in a concentration of 0.5 to 4.0% by weight, preferably 1.0 to 2.5% by weight, based on the total weight of the cosmetic composition in the O / W formulation. If the solid lipid component is less than 0.5% by weight, the nanoemulsion becomes unstable, and when used in excess of 4.0% by weight, the solubility of the solid lipid component is not good.

In addition, the liquid oil component is contained in a concentration of 3.0 to 25.0% by weight, preferably 5.0 to 15.0% by weight based on the total weight of the cosmetic composition in the O / W formulation. When the liquid oil is less than 3.0% by weight, it is difficult to dissolve the solid lipid component, and when the oil content is 25.0% by weight or more, the oil component may be floated up or separated. In addition, when a large amount of the liquid oil component is used to increase the solubility of the solid lipid component, it is not good in terms of feeling.

In addition, water-soluble moisturizers and water-soluble thickeners commonly used in cosmetics can be adjusted according to the purpose and use of each product, and in particular, the thickener is a dispersion stabilizing material of poorly soluble substances, which prevents creaming of nanoemulsion formulations and It is a component for allowing the formulation to have a viscosity to be wetted, and selects a suitable thickener suitable for the product to increase it, and preferably contains it at a concentration of 0.05 to 0.5% by weight based on the total weight of the cosmetic composition. If less than 0.05% by weight of the nanoemulsion may be the creaming phenomenon, and when used in excess of 0.5% by weight is high viscosity is poor compatibility with the sheet.

The water thickener is also selected from the group consisting of carbomers, polyacrylamides, ammonium acryloyldimethyltorate / V copolymers, xanthan gum, cellulose ethers, polyvinyl derivatives, alginates, polyacrylates and mixtures thereof It is characterized by.

Sheet mask formulation developed by the present invention can increase the efficacy on the skin, including not only the moisturizing nutritional function of the general sheet type but also poorly soluble agonist that the general sheet product can not have.

Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited to the following examples and experimental examples.

Example 1, Comparative Examples 1 to 3 Preparation of a low viscosity sheet impregnation liquid and sheet impregnation

To prepare a sheet impregnation solution containing 2.5% liposomes stabilized oleanolic acid in poorly soluble substances in the compositions of Tables 1, 2, and 3 below.

Example 1 of Table 1 is a low viscosity nanoemulsion solution, Comparative Example 1 of Table 2 is a low viscosity 0 / W emulsifier type, Comparative Example 2 of Table 3 is a solubilized formulation without viscosity, Comparative Example 3 It is a formulation in which a liposome base is dispersed 2.5% in a solubilized formulation.

The oleanolic acid bases used in the following Tables 1 to 3 are used after the oleanolic acid is dispersed in alcohol and polyol, mixed with phospholipid, and then liposomeized using a high pressure emulsifier.

Ingredient Example 1 Purified water To 100 Oleanolic acid liposome base 2.5 ethanol 5 Polyglyceryl monostearate 0.8 Hydrogenated Lecithin One Stearic acid 0.3 Hydrogenated Polydecene 3 Squalane 2 Dimethicone 2 glycerin 5 Thickener (Carbomer) 0.1 Preservative, incense Quantity corrector Quantity

Ingredient Comparative Example 1 Purified water To 100 Oleanolic acid liposome base 2.5 Glyceryl Stearate 0.8 Stearic acid 0.5 Cetearyl Alcohol 0.8 Hydrogenated Dressin / C12-16 Alcohol / Palmetic Acid 0.4 Hydrogenated Polydecene 3 Cetyloctanoate 2 Dimethicone 0.5 glycerin 5 Thickener (Carbomer) 0.1 Preservative, incense Quantity corrector Quantity

Ingredient Comparative Example 2 Comparative Example 3 Purified water To 100 To 100 Oleanolic acid liposome base 2.5 2.5 glycerin 5 5 Alcohol 7 7 Polyoxyethylene Hydrogenated Castor Oil 0.5 0.5 Thickener (Carbomer) 0.05 0.1 Preservative, incense Quantity Quantity corrector Quantity Quantity

Experimental Example 1

After preparing each sample obtained in Example 1 and Comparative Examples 1, 2, and 3, the samples were taken the next day and stored in a thermostatic chamber for 30 days at 45 ° C. When tested for compatibility with the sheet, and shown in Table 4.

ingredient Viscosity (30 ℃) Stability after 30 days Compatibility with the seat Liposomal Dispersion in Sheets Example 1 2250 stability Good sheet impregnation Evenly good Comparative Example 1 2500 Unstable Formulation, Separation No sheet impregnation no Comparative Example 2 500 Creation of Cream Good sheet impregnation no Comparative Example 3 2000 Creation of Cream Good sheet impregnation no

As shown in Table 4, the nanoemulsion formulation of Example 1 has better dispersion stability of the poorly soluble liposome base than the general low viscosity emulsion of Comparative Example 1 or the solubilizing formulation of Comparative Examples 2 and 3. It was confirmed that the compatibility is good and evenly dispersed liposomes.

[Experimental Example 2] Comparative experiment of the feeling by the

With Example 1 and Comparative Example 3 was tested on the usability of 30 general monitor personnel of women in their 30s to 50s, the results are shown in FIG.

In general, consumers using sheet masks require a moist and nutritious feeling. In addition, the use of a highly concentrated sheet mask containing a potent ingredient was considered important because of the speed at which the potent ingredient was absorbed and whether the potency was actually felt on the skin. Compared to Comparative Example 3, in the case of Example 1, it can be seen that the moisturization after use is superior, and thus, it has an advantage in moisturizing feeling which is a basic property of the sheet mask. In addition, in Example 1, since the liposome base containing the poorly soluble substance is uniformly dispersed and the particle size of the nanoemulsion is about 200 nm, the absorption rate of the contents is faster than that of Comparative Example 3, and has an advantage in terms of usability. Even distribution had a big influence on the customer's perception of efficacy.

Experimental Example 3 Measurement of Wrinkle Improvement Effect of Human

In order to confirm the wrinkle improvement effect of Example 1 and Comparative Example 3 was evaluated as follows.

Example 1 and Comparative Example 3 were applied to each of the 21 women in their 30s with healthy wrinkles around the face and the sheet masks were applied for 8 weeks, 5 days a week. Subjects were randomly divided into two groups according to the left and right sides of the face, and Example 1 and Comparative Example 3 were applied to the face five times a week for about 20 minutes on the face, and after removing the product, the remaining cosmetics were rubbed to be absorbed evenly. The evaluation method is to make a copyboard for visual evaluation of eye wrinkles and facial fixation equipment set and lighting set for wrinkle photographing, and a photographic and facial eye wrinkle test site by high-resolution digital camera (OLYMPUS E-1, JAPAN), and Visiometer (Skin -Visiometer SV 600, Courage & Khazaka, Germany) was used to analyze the wrinkles of the skin wrinkles (Image Analysis) of the wrinkles (Replica) by analyzing the changes in the skin wrinkles.

The visual evaluation of the subject's eye wrinkles was scored from 0 to 7 points and displayed according to the use time, and the results are shown in Table 5 and FIG. 2. As a result of using Example 1 and Comparative Example 3 for 8 weeks, the visual evaluation score of Example 1 was further reduced than that of Comparative Example 3, and accordingly, wrinkles were further reduced.

number Comparative Example 3 Example 1 Week 0 4 Weeks 6 Weeks 8 Weeks Week 0 4 Weeks 6 Weeks 8 Weeks One 3 3 3 3 3 3 3 3 2 5 5 4 5 5 4 5 4 3 4 4 5 4 4 4 4 4 4 4 3 4 4 4 4 4 4 5 5 5 5 5 5 4 4 4 6 5 5 4 4 4 3 4 4 7 5 5 5 5 6 5 6 5 8 5 5 4 4 6 6 6 6 9 5 5 5 4 5 4 4 4 10 6 5 6 6 6 6 5 4 11 3 4 4 4 4 4 4 4 12 5 5 5 5 5 4 5 5 13 6 6 6 6 6 6 6 6 14 3 3 4 3 5 4 3 2 15 4 4 2 3 4 3 3 4 16 4 3 4 4 4 3 4 4 17 3 4 3 3 3 4 3 3 18 4 3 3 3 3 3 2 2 19 5 5 5 5 4 4 3 3 20 5 5 5 5 5 5 5 5 21 4 4 4 4 4 5 4 4 Average 4.43 4.33 4.29 4.24 4.52 4.19 4.14 4.00 Standard Deviation 0.93 0.91 1.01 0.94 0.98 0.98 1.11 1.05

In the eyes around the product using a silicone material to produce a replica plate. The mock plate was manufactured under constant temperature and humidity (22 ± 2 ℃, 40% ~ 60% humidity), and the subject was not allowed to apply all cosmetics such as skin on the day of measurement. In addition, after the hair removal centering around the part of the mock-up plate was washed, and then stabilized in a constant temperature and humidity (22 ± 2 ℃, 40% ~ 60% humidity) conditions for 30 minutes, it was prepared using a silicone solution, a catalyst. The wrinkles of the skin were analyzed by using a Visiometer.The principle of analysis was to measure the intensity of skin wrinkles by analyzing the intensity of the light emitted from the artificial light source through the silicon material by Lambert &Beer's Law. I _ex = I _in e ^{- kd} ). The analysis results are summarized by analyzing the values of R1 ~ R5. As the value of R1 ~ R5 decreases, skin wrinkles are improved and the depth of wrinkles is lowered. The unit is an arbitrary unit. Where R1 is the Skin Roughness (distance between the point of the highest wrinkle and the point of the lowest wrinkle), R2 is the Maximum Roughness (the wrinkle is automatically divided into five pieces, respectively, to obtain R1, and then the highest R1 value among the divided wrinkles), R3 Is the average roughness (average of the R1 values obtained by dividing into five), R4 is the smoothness depth (the average value of each peak and valley subtracted from the baseline of the wrinkle contour line), and R5 is the Arithmetic Average Roughness Difference value excluding wrinkle contour). The results are shown in Table 6 below, and after 8 weeks of testing, it was confirmed that a statistically significant level difference occurred in R3 as a result of statistical analysis on the change in the image analysis of the replica plate between Example 1 and Comparative Example 3.

R3 means average roughness of the depths of the maximum wrinkles in each region in the five divided regions as described above. Therefore, the statistically significant decrease in R3 means that Example 1 has an anti-wrinkle effect compared to Comparative Example 3.

Results of simulated plate image analysis between Comparative Example 3 and Example 1 after using the product No. Comparative Example 3 Example 1 R1 R2 R3 R4 R5 R1 R2 R3 R4 R5 Average Week 0 0.45 0.31 0.21 0.21 0.07 0.42 0.30 0.21 0.19 0.07 4 Weeks 0.49 0.30 0.20 0.22 0.08 0.45 0.28 0.19 0.21 0.08 6 Weeks 0.46 0.30 0.20 0.21 0.08 0.43 0.27 0.19 0.20 0.07 8 Weeks 0.43 0.29 0.19 0.18 0.07 0.42 0.26 0.18 0.20 0.07 Standard Deviation Week 0 0.09 0.06 0.04 0.06 0.02 0.09 0.05 0.03 0.04 0.02 4 Weeks 0.10 0.09 0.06 0.04 0.02 0.08 0.05 0.03 0.04 0.02 6 Weeks 0.08 0.07 0.05 0.05 0.02 0.09 0.04 0.03 0.05 0.02 8 Weeks 0.09 0.06 0.03 0.05 0.02 0.09 0.05 0.03 0.05 0.02

As can be seen from the results, it can be seen that the skin wrinkle improvement effect of Example 1 is very excellent.

As described above, the present invention is a low-viscosity nanoemulsion emulsion-like sheet mask cosmetic which stably contains a poorly soluble substance effective on the skin and can be impregnated into a sheet, and impregnated the poorly soluble substance collected by liposomes into the sheet. By using nanoemulsion of low viscosity fluid to stabilize dispersion in time, it improves the dispersibility of poorly soluble liposome which is impossible in the existing low viscosity formulation, so that the sheet can be impregnated while maintaining the activity of the active ingredient for a long time. Since it shows an excellent effect that the efficacy is increased, the present invention provides a cosmetic composition having a different effect and sensitivity than the existing.

Claims (11)

A cosmetic comprising a sheet, wherein the cosmetic composition comprises a sheet impregnated with a low viscosity nanoemulsion containing a liposome-formed poorly soluble substance. The poorly soluble material of claim 1, wherein the poorly soluble material is retinol and retinol derivatives (retinylacetate, retinyl palmitate), tocopherol, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, linoleic acid, coenzyme Q-10 Resveratrol, plant extract essential oils, ursolic acid, oleanolic acid, oil-soluble licorice and lipoic acid cosmetic composition comprising one or more selected from the group consisting of. The cosmetic composition according to claim 1, wherein the content of the poorly soluble liposome used is 1 to 10% by weight based on the total weight of the cosmetic composition. The cosmetic composition according to claim 1, wherein the nanoemulsion contains a lipid component, a liquid oil, a humectant, and an aqueous thickener as a formulation skeleton component. The cosmetic composition according to claim 1, wherein the low viscosity of the emulsion is 300 to 3000 CPS. The cosmetic composition according to claim 4, wherein the content of the lipid component is 0.5 to 4.0% by weight based on the total weight of the cosmetic composition. The cosmetic composition according to claim 6, wherein the content of the lipid component is 1.0 to 2.5% by weight based on the total weight of the cosmetic composition. The cosmetic composition according to claim 4, wherein the content of the component of the liquid oil is 3.0 to 25.0% by weight based on the total weight of the cosmetic composition. The cosmetic composition according to claim 8, wherein the content of the component of the liquid oil is 5.0 to 15.0% by weight based on the total weight of the cosmetic composition. The cosmetic composition according to claim 4, wherein the content of the water-based thickener is 0.05 to 0.5 wt% based on the total weight of the cosmetic composition. The method of claim 4 wherein the water thickener is carbomer, polyacrylamide, ammonium acryloyldimethyltorate / V copolymer, xanthan gum, cellulose ether, polyvinyl derivative, alginate, polyacrylate and mixtures thereof Cosmetic composition, characterized in that selected from the group consisting of.

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