CN107049906B

CN107049906B - Skin care product with quick water replenishing and long-term moisture preserving effects and preparation method thereof

Info

Publication number: CN107049906B
Application number: CN201710408064.9A
Authority: CN
Inventors: 秦正红; 张伟
Original assignee: Chongqing Institute Of Bench To Bed Bioengineering Technology Co ltd
Current assignee: Chongqing Institute Of Bench To Bed Bioengineering Technology Co ltd
Priority date: 2017-06-02
Filing date: 2017-06-02
Publication date: 2020-08-11
Anticipated expiration: 2037-06-02
Also published as: CN107049906A

Abstract

The invention particularly relates to a skin care product with the effects of quickly supplementing water and keeping moisture for a long time and a preparation method thereof. The composition comprises the following raw materials: 50-75 parts of dendrobium officinale extract and 15-40 parts of deodorized snake oil. The skin care product prepared by the invention not only has the effects of quickly supplementing water and preserving moisture for a long time, but also has better long-term stability, high-temperature stability and low-temperature stability, has no skin irritation and higher safety, and meets the requirements of skin care product preparation, so that the skin care product can be used for preparing the skin care product.

Description

Skin care product with quick water replenishing and long-term moisture preserving effects and preparation method thereof

Technical Field

The invention belongs to the field of daily chemical products, and particularly relates to a skin care product with quick water replenishing and long-term moisture preserving effects and a preparation method thereof.

Background

The skin is the natural coat of human body and is generally divided into three major parts, namely epidermis, dermis and subcutaneous tissue from outside to inside, and the epidermis is further divided into a cuticle layer, a stratum lucidum layer, a stratum granulosum layer, a acanthosphere layer and a stratum basale layer. The stratum corneum, the outermost layer of the skin, plays an important role in the integrity of the skin barrier function. A sebum membrane is formed on the horny layer, and is a semitransparent milky membrane formed by emulsifying sebum, sweat and epidermal cell secretion, and free fatty acid, lactate, urea and uric acid in the sebum membrane are natural moisturizing factors and play a role in moisturizing the skin. The stratum corneum and sebaceous membrane prevent the loss of water from the skin. When the moisture of the surface layer of the human skin is 12-15%, the skin is smooth and elastic; skin dryness can be caused if the skin lacks moisture. Skin dryness refers to the phenomenon that skin lacks moisture and feels uncomfortable, and the symptoms mainly include skin tightness, dry and desquamation of individual parts, general itching after bathing and the like, and the reasons include: age, climate change, sleep deficiency, fatigue, bath water overheating, strong alkalinity of washing products, and the like. Studies have shown that eyes in a dry state for 3 hours are dark and dull within a day, and are not conscious; the hands are in a dry state for 1 day, and the original elasticity needs to be recovered for 3 days; when the face is in a dry state for 3 days, the skin can be peeled, wrinkles and skin pigment can be grown, and when the dry time exceeds 7 days, color spots and accumulated toxin can be generated, and even 3 months are needed for recovering the original state; if the whole body is dry for more than 30 days, various intractable color spots and wrinkles are generated, and the skin aging speed is accelerated for 3 years.

At present, the use of skin care products with moisturizing effects is one of the methods for improving dry skin. However, some existing skin care products can rapidly replenish water but have poor water locking effect, such as dendrobium officinale leaf extract reported in patent documents; some skin care products have good water locking effect but poor water replenishing effect, and like the snake oil which is a pure natural skin care product in China, the skin care products can not fundamentally improve the phenomenon of dry skin, thereby limiting the application of the skin care products.

Therefore, the research on the skin care product with the effects of quickly supplementing water and preserving moisture for a long time has important significance.

Disclosure of Invention

Therefore, the invention aims to solve the technical problems that some skin care products in the existing skin care products can quickly replenish water but have a poor water locking effect, and some skin care products have a good water locking effect but have a poor water replenishing effect, so that the skin care products with the effects of quickly replenishing water and preserving moisture for a long time are provided, and further the preparation method of the skin care products is provided.

In order to solve the technical problems, the invention is realized by the following technical scheme:

the invention provides a composition with the effects of quickly supplementing water and keeping moisture for a long time, which comprises the following raw materials: 50-75 parts of dendrobium officinale extract and 15-40 parts of deodorized snake oil.

Preferably, the composition with the effects of quickly supplementing water and preserving moisture for a long time at the same time is prepared from the dendrobium officinale extract by the following method: pulping the stems of the dendrobium officinale, adding water with the weight of 2-10 times of the stems, stirring until the mixture is uniformly emulsified, filtering and sterilizing to obtain the dendrobium officinale drink.

Preferably, in the composition having both the effects of rapid water supplement and long-term moisture retention, the content of the dendrobium polysaccharide in the dendrobium officinale is 29%, which is higher than the content standard of dendrobium polysaccharide in the national pharmacopoeia, namely 25%.

Preferably, in the composition with the effects of quickly supplementing water and preserving moisture for a long time, the unsaturation degree of the deodorized snake oil is 88-91.

Preferably, in the composition with both effects of quickly supplementing water and preserving moisture for a long time, the deodorized snake oil is prepared by the following method:

removing impurities from fresh snake oil, and pulping to obtain snake oil raw pulp;

adding water with the weight of 0.5-5 times of the weight of the snake oil primary pulp and the temperature of 70-80 ℃ into the snake oil primary pulp, stirring until the mixture is uniformly mixed, standing, and cooling to room temperature to obtain a snake oil mixed solution A;

cooling the snake oil mixed solution A to 0-5 ℃, condensing, and taking white colloidal snake oil on the upper layer formed after condensation;

heating the upper layer white colloidal snake oil to 20-30 ℃ to melt the upper layer white colloidal snake oil, adding 0.5-5 times of ethanol by weight, and stirring until the mixture is uniformly mixed to obtain a snake oil mixed solution B;

and (4) centrifuging the snake oil mixed liquor B until the snake oil mixed liquor B is clear and decolored to obtain the deodorized snake oil.

The invention also provides application of the composition in preparing a skin care product with the effects of quickly supplementing water and keeping moisture for a long time.

The invention also provides a skin care product with the effects of quickly supplementing water and keeping moisture for a long time, which comprises the composition.

Preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time is selected from toner, emulsion and cream.

Preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time also comprises: 9.8 to 10.2 parts by weight of surfactant and 0.01 to 0.5 part by weight of preservative.

Further preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time also comprises: 10 parts of surfactant and 0.01-0.5 part of preservative.

Further preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time simultaneously comprises a surfactant selected from span 80 and/or tween 80, and the preservative is benzalkonium chloride.

Further preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time simultaneously comprises the surfactant selected from span 80 and tween 80, wherein the weight ratio of the span 80 to the tween 80 is 97: 3.

further preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time simultaneously comprises the following raw materials: 50-75 parts of dendrobium officinale extract, 15-40 parts of deodorized snake oil, 809.506-9.894 parts of span, 800.294-0.306 part of tween and 0.01-0.5 part of benzalkonium chloride.

Further preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time simultaneously comprises the following raw materials: 50-75 parts of dendrobium officinale extract, 15-40 parts of deodorized snake oil, 809.70 parts of span, 800.30 parts of tween and 0.01-0.5 part of benzalkonium chloride.

Further preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time simultaneously comprises the following raw materials: 50 parts of dendrobium officinale extract, 40 parts of deodorized snake oil, 809.70 parts of span, 800.30 parts of tween and 0.3 part of benzalkonium chloride.

Further preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time simultaneously comprises the following raw materials: 55 parts of dendrobium officinale extract, 35 parts of deodorized snake oil, 809.70 parts of span, 800.30 parts of tween and 0.1 part of benzalkonium chloride.

Further preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time simultaneously comprises the following raw materials: 60 parts of dendrobium officinale extract, 30 parts of deodorized snake oil, 809.70 parts of span, 800.30 parts of tween and 0.03 part of benzalkonium chloride.

Further preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time simultaneously comprises the following raw materials: 65 parts of dendrobium officinale extract, 25 parts of deodorized snake oil, 809.70 parts of span, 800.30 parts of tween and 0.4 part of benzalkonium chloride.

Further preferably, the skin care product with the effects of quickly supplementing water and keeping moisture for a long time simultaneously comprises the following raw materials: 75 parts of dendrobium officinale extract, 15 parts of deodorized snake oil, 809.70 parts of span, 800.30 parts of tween and 0.01 part of benzalkonium chloride.

The invention also provides a preparation method of the skin care product with the effects of quickly replenishing water and keeping moisture for a long time, which comprises the following steps:

respectively taking the dendrobium officinale extract in selected parts by weight and 3% of surfactant in selected parts by weight, stirring and uniformly mixing to obtain reaction liquid A;

respectively taking the deodorized snake oil in selected parts by weight and 97% of surfactant in selected parts by weight, and stirring until the components are uniformly mixed to obtain reaction liquid B;

slowly adding the reaction liquid C into the reaction liquid B under stirring, and stirring until the mixture is uniformly emulsified to obtain a reaction liquid D;

and adding the preservative in the selected weight part into the reaction liquid D, and stirring until the mixture is uniformly emulsified to obtain the emulsion.

Preferably, the preparation method of the skin care product with the effects of quickly supplementing water and keeping moisture for a long time at the same time comprises the following steps:

respectively taking the selected weight parts of the dendrobium officinale extract and the selected weight parts of tween 80, stirring and uniformly mixing to obtain reaction liquid A;

respectively taking the deodorized snake oil in selected parts by weight and span 80 in selected parts by weight, and stirring until the components are uniformly mixed to obtain a reaction solution B;

adding benzalkonium chloride in selected weight portions into the reaction liquid D, and stirring until emulsification is uniform.

Preferably, the preparation method of the skin care product with the effects of quickly supplementing water and keeping moisture for a long time simultaneously further comprises the step of sterilizing the dendrobium officinale extract before the step of taking the dendrobium officinale extract in selected parts by weight.

Compared with the prior art, the technical scheme of the invention has the following advantages:

(1) the skin care product disclosed by the invention takes the dendrobium officinale extract and the deodorized snake oil as raw materials, and the raw materials are matched and act together in a specific ratio, so that the skin care product not only has the effect of quickly replenishing water, but also has the effect of preserving moisture for a long time, and therefore, the problem of skin water shortage can be fundamentally solved, and the symptom of dry skin is improved;

(2) according to the skin care product, span 80 and tween 80 are further selected as surfactants, benzalkonium chloride is selected as a preservative, and the specific auxiliary materials are matched and act together with the raw materials in a specific ratio, so that the skin care product not only has good long-term stability, but also has good high-temperature stability and low-temperature stability;

(3) according to the skin care product disclosed by the invention, the dendrobium officinale extract is subjected to sterilization treatment, so that the irritation to the skin is reduced, and the safety is higher.

Detailed Description

In the following embodiments and experimental examples of the invention, dendrobium officinale is known by the scientific name: dendrobium officinalis Kimuraet Migo; the content of the dendrobium polysaccharide in the dendrobium officinale extract is measured by adopting a phenol-sulfuric acid colorimetric method (refer to the research of a polysaccharide content measuring method in the research of new traditional Chinese medicines, 2016, 28(19), 56-56) in the Chinese national health medicine); the method for measuring the content of unsaturated fatty acid in deodorized snake oil comprises the following steps: measuring an iodine value by an iodine tincture method to represent the unsaturation degree of the deodorized snake oil, wherein the higher the iodine value is, the higher the unsaturation degree of the deodorized snake oil is, the higher the content of unsaturated fatty acid contained in the deodorized snake oil is; the raw material of deodorized snake oil is fresh snake oil (i.e. oil and fat extracted from fresh snake body), and the specific type of snake is not limited, and various kinds of snake known in the art can be selected.

Example 1Preparation of dendrobium officinale extract

The dendrobium officinale extract is prepared by the following method: pulping the stems of the dendrobium officinale, adding 6 times of water by weight, stirring until the mixture is uniformly emulsified, performing suction filtration, and performing filtration sterilization to obtain the dendrobium officinale drink.

Through determination, the content of dendrobium polysaccharide in the dendrobium officinale extract prepared in the embodiment is 6.2%.

Example 2Preparation of dendrobium officinale extract

The dendrobium officinale extract is prepared by the following method: pulping the stems of the dendrobium officinale, adding 2 times of water by weight, stirring until the mixture is uniformly emulsified, performing suction filtration, and performing filtration sterilization to obtain the dendrobium officinale drink.

Through determination, the content of dendrobium polysaccharide in the dendrobium officinale extract prepared in the embodiment is 15.9%.

Example 3Preparation of dendrobium officinale extract

The dendrobium officinale extract is prepared by the following method: pulping the stems of the dendrobium officinale, adding 10 times of water by weight, stirring until the mixture is uniformly emulsified, performing suction filtration, and performing filtration sterilization to obtain the dendrobium officinale drink.

Through determination, the content of dendrobium polysaccharide in the dendrobium officinale extract prepared in the embodiment is 3.4%.

Example 4Preparation method of deodorized snake oil

The deodorized snake oil is prepared by the following method:

secondly, adding 3 times of water with the temperature of 75 ℃ by weight into the snake oil primary pulp based on the weight of the snake oil primary pulp, stirring the mixture until the mixture is uniformly mixed, standing the mixture, and cooling the mixture to room temperature to obtain snake oil mixed liquid A;

thirdly, cooling the snake oil mixed liquid A to 2 ℃, condensing, and taking the upper white colloidal snake oil formed after condensation;

fourthly, heating the upper layer white colloidal snake oil to 25 ℃ to melt the upper layer white colloidal snake oil, adding 3 times of ethanol by weight, and stirring the mixture until the mixture is uniformly mixed to obtain a snake oil mixed solution B;

and (4) centrifuging the snake oil mixed liquor B to be clear, and decoloring by using active carbon to obtain the deodorized snake oil.

The determination shows that the unsaturation degree of the deodorized snake oil prepared in the example is 89.5.

Example 5Preparation method of deodorized snake oil

The deodorized snake oil is prepared by the following method:

secondly, adding water with the weight of 0.5 time and the temperature of 80 ℃ into the snake oil primary pulp based on the weight of the snake oil primary pulp, stirring the mixture until the mixture is uniformly mixed, standing the mixture, and cooling the mixture to room temperature to obtain snake oil mixed liquid A;

thirdly, cooling the snake oil mixed liquid A to 0 ℃, condensing, and taking the upper white colloidal snake oil formed after condensation;

fourthly, heating the upper layer white colloidal snake oil to 30 ℃ to melt the upper layer white colloidal snake oil, adding 0.5 times of ethanol by weight, and stirring the mixture until the mixture is uniformly mixed to obtain a snake oil mixed solution B;

The determination shows that the unsaturation degree of the deodorized snake oil prepared by the embodiment is 88.8.

Example 6Preparation method of deodorized snake oil

The deodorized snake oil is prepared by the following method:

secondly, adding 5 times of water with the temperature of 70 ℃ into the snake oil primary pulp by taking the weight of the snake oil primary pulp as a reference, stirring until the mixture is uniformly mixed, standing, and cooling to room temperature to obtain a snake oil mixed solution A;

thirdly, cooling the snake oil mixed liquid A to 5 ℃, condensing, and taking the upper white colloidal snake oil formed after condensation;

fourthly, heating the upper layer white colloidal snake oil to 20 ℃ to melt the upper layer white colloidal snake oil, adding 5 times of ethanol by weight, and stirring the mixture until the mixture is uniformly mixed to obtain a snake oil mixed solution B;

The determination shows that the unsaturation degree of the deodorized snake oil prepared by the embodiment is 90.4.

Example 7

The skin care product of the embodiment comprises the following raw materials: 50g of dendrobium officinale extract prepared in example 1, 40g of deodorized snake oil prepared in example 4, 809.70 g of span, 800.30 g of tween and 0.3g of benzalkonium chloride;

the preparation method of the skin care product comprises the following steps:

(1) sterilizing the dendrobium officinale extract;

(2) respectively taking the dendrobium officinale extract with the selected weight and the tween 80 with the selected weight, stirring and uniformly mixing to obtain reaction liquid A;

(3) respectively taking the deodorized snake oil with the selected weight and span 80 with the selected weight, and stirring until the materials are uniformly mixed to obtain reaction liquid B;

(4) slowly adding the reaction liquid C into the reaction liquid B under stirring, and stirring until the mixture is uniformly emulsified to obtain a reaction liquid D;

(5) adding benzalkonium chloride of selected weight into the reaction solution D, and stirring until emulsification is uniform.

Example 8

The skin care product of the embodiment comprises the following raw materials: 55g of dendrobium officinale extract prepared in example 1, 35g of deodorized snake oil prepared in example 4, 809.70 g of span, 800.30 g of tween and 0.1g of benzalkonium chloride;

the preparation method of the skin care product comprises the following steps:

(1) sterilizing the dendrobium officinale extract;

Example 9

The skin care product of the embodiment comprises the following raw materials: 60g of dendrobium officinale extract prepared in example 1, 30g of deodorized snake oil prepared in example 4, 809.70 g of span, 800.30 g of tween and 0.03g of benzalkonium chloride;

the preparation method of the skin care product comprises the following steps:

(1) sterilizing the dendrobium officinale extract;

Example 10

The skin care product of the embodiment comprises the following raw materials: 65g of dendrobium officinale extract prepared in example 1, 25g of deodorized snake oil prepared in example 4, 809.70 g of span, 800.30 g of tween and 0.4g of benzalkonium chloride;

the preparation method of the skin care product comprises the following steps:

(1) sterilizing the dendrobium officinale extract;

Example 11

The skin care product of the embodiment comprises the following raw materials: 75g of dendrobium officinale extract prepared in example 1, 15g of deodorized snake oil prepared in example 4, 809.70 g of span, 800.30 g of tween and 0.01g of benzalkonium chloride;

the preparation method of the skin care product comprises the following steps:

(1) sterilizing the dendrobium officinale extract;

Comparative example 1

The skin care product of this comparative example differs from example 7 only in the following raw materials: 50g of the dendrobium officinale extract prepared in the example 1 is replaced by 30g of the dendrobium officinale extract prepared in the example 1, and the rest raw materials and the mixture ratio are the same as those in the example 7.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: 50g of the dendrobium officinale extract prepared in example 1 is replaced by 30g of the dendrobium officinale extract prepared in example 1, and the rest experimental conditions and experimental operation steps are the same as those in example 7.

Comparative example 2

The skin care product of this comparative example differs from example 7 only in the following raw materials: 50g of the dendrobium officinale extract prepared in the example 1 is replaced by 80g of the dendrobium officinale extract prepared in the example 1, and the rest raw materials and the mixture ratio are the same as those in the example 7.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: 50g of the dendrobium officinale extract prepared in example 1 is replaced by 80g of the dendrobium officinale extract prepared in example 1, and the rest experimental conditions and experimental operation steps are the same as those in example 7.

Comparative example 3

The skin care product of this comparative example differs from example 7 only in the following raw materials: 50g of the dendrobium officinale extract prepared in example 1 is replaced by 0g of the dendrobium officinale extract prepared in example 1, and the rest raw materials and the mixture ratio are the same as those in example 7.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: 50g of the dendrobium officinale extract prepared in example 1 is replaced by 0g of the dendrobium officinale extract prepared in example 1, and the rest experimental conditions and experimental operation steps are the same as those in example 7.

Comparative example 4

The skin care product of this comparative example differs from example 7 only in the following raw materials: 40g of the deodorized snake oil prepared in example 4 is replaced by 15g of the deodorized snake oil prepared in example 4, and the rest raw materials and the mixture ratio are the same as those in example 7.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: the fishy smell removed snake oil prepared in example 4 was replaced by 40g of the fishy smell removed snake oil prepared in example 4, and the rest of the experimental conditions and the experimental operation steps were the same as those of example 7.

Comparative example 5

The skin care product of this comparative example differs from example 7 only in the following raw materials: 40g of the deodorized snake oil prepared in example 4 is replaced by 47g of the deodorized snake oil prepared in example 4, and the rest raw materials and the mixture ratio are the same as those in example 7.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: 40g of deodorized snake oil prepared in example 4 was replaced by 47g of deodorized snake oil prepared in example 4, and the rest of the experimental conditions and experimental procedures were the same as those in example 7.

Comparative example 6

The skin care product of this comparative example differs from example 7 only in the following raw materials: 40g of the deodorized snake oil prepared in example 4 is replaced by 0g of the deodorized snake oil prepared in example 4, and the rest raw materials and the mixture ratio are the same as those in example 7.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: the deodorized snake oil prepared in example 4 (40 g) was replaced by 0g prepared in example 4, and the rest of the experimental conditions and experimental procedures were the same as those in example 7.

Comparative example 7

The skin care product of this comparative example differs from example 8 only in the following raw materials: 0.1g of benzalkonium chloride is replaced by 0.1g of phenoxyethanol, and the rest raw materials and the mixture ratio are the same as those in the example 8.

The skin care product of this comparative example was prepared by a method that differed from example 8 only in that: the experimental conditions and experimental procedures were the same as in example 8 except that 0.1g of benzalkonium chloride was replaced by 0.1g of phenoxyethanol.

Comparative example 8

The skin care product of this comparative example differs from example 9 only in the following raw materials: 0.03g of benzalkonium chloride is replaced by 0.03g of cason, and the rest raw materials and the mixture ratio are the same as those in the example 9.

The skin care product of this comparative example was prepared by a method that differed from example 9 only in that: the experimental conditions and experimental procedures were the same as in example 9 except that 0.03g of benzalkonium chloride was replaced by 0.03g of cason.

Comparative example 9

The skin care product of this comparative example differed from example 10 only in that: 0.4g of benzalkonium chloride was substituted by 0.4g of DMDMH, and the other raw materials and the compounding ratio thereof were the same as in example 10.

The skin care product of this comparative example was prepared by a method different from that of example 10 only in that: the benzalkonium chloride 0.4g was replaced by DMDMH0.4g, and the experimental conditions and experimental procedures were the same as in example 10.

Comparative example 10

The skin care product of this comparative example differs from example 7 only in the following raw materials: the raw materials and the mixture ratio of the span 809.70 g are the same as those in the example 7, but the span 8010 g is replaced by the span 809.70 g.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: span 809.70 g was replaced by span 8010 g, and the rest of the experimental conditions and experimental procedures were the same as in example 7.

Comparative example 11

The skin care product of this comparative example differs from example 7 only in the following raw materials: the raw materials and the mixture ratio of the span 809.70 g are the same as those in the example 7, except that the span 809.40 g is replaced by the span 809.70 g.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: the experimental conditions and experimental procedures were the same as in example 7 except that span 809.70 g was replaced by span 809.40 g.

Comparative example 12

The skin care product of this comparative example differs from example 7 only in the following raw materials: the rest raw materials and the mixture ratio are the same as those in example 7 except that the Tween 800.30 g is replaced by Tween 800.28 g.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: the same experimental conditions and procedures as in example 7 were used except that Tween 800.30 g was replaced by Tween 800.28 g.

Comparative example 13

The skin care product of this comparative example differs from example 7 only in the following raw materials: the rest raw materials and the mixture ratio are the same as those in example 7 except that the Tween 800.30 g is replaced by Tween 800.35 g.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: the same experimental conditions and procedures as in example 7 were used except that Tween 800.30 g was replaced by Tween 800.35 g.

Comparative example 14

The skin care product of this comparative example differs from example 7 only in the following raw materials: the raw materials and the mixture ratio are the same as those in example 7 except that 809.70 g of span is replaced by 9.70g of alkyl glycoside.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: the experimental conditions and experimental procedures were the same as in example 7 except that 809.70 g of span was replaced by 9.70g of alkyl glycoside.

Comparative example 15

The skin care product of this comparative example differs from example 7 only in the following raw materials: the raw materials and the mixture ratio of the raw materials are the same as those in example 7 except that 809.70 g of span is replaced by 9.70g of isopropyl palmitate.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: the experimental conditions and experimental procedure were the same as in example 7 except that 809.70 g of span was replaced by 9.70g of isopropyl palmitate.

Comparative example 16

The skin care product of this comparative example differs from example 7 only in the following raw materials: the same procedures as in example 7 were repeated except that 0.30g of caprylic/capric triglyceride was substituted for 800.30 g of Tween, and the other materials and the compounding ratios thereof were the same.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: the experimental conditions and procedures were the same as in example 7 except that 0.30g of caprylic/capric triglyceride was substituted for 800.30 g of Tween.

Comparative example 17

The skin care product of this comparative example differs from example 7 only in the following raw materials: the rest of the raw materials and the mixture ratio thereof were the same as in example 7 except that 0.30g of lecithin was substituted by 800.30 g of Tween.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: the same experimental conditions and procedures as in example 7 were used except that 0.30g of lecithin was used instead of 800.30 g of Tween.

Comparative example 18

The skin care product of this comparative example was prepared from the same raw materials as in example 7.

The skin care product of this comparative example was prepared by a method that differed from example 7 only in that: does not comprise the following steps: sterilizing the dendrobium officinale extract; the rest of the experimental conditions and experimental procedures were the same as in example 7.

Experimental example 1Research on quick water replenishing and long-term moisturizing effects of skin care product on skin

1. Purpose of experiment

The skin care product of the invention is studied for the effects of rapid water replenishment and long-term moisturizing of the skin.

2. Experimental methods

2.1 Experimental Environment, Experimental instruments and test articles

The experimental environment is as follows: the indoor temperature is 19 ℃ and the humidity is 38%;

an experimental instrument: a cassava moisture detector;

the skin care products prepared in examples 7 to 11 were used as test products in experimental groups 1 to 5, and the skin care products prepared in comparative examples 1 to 6 were used as test products in comparative groups 1 to 6.

2.2 Experimental procedures

120 skin dry subjects (the moisture content of the skin is less than or equal to 12%) with the age range of 30-50 years are selected and randomly divided into a blank control group, a control group 1-6 group and an experimental group 1-5 group, wherein each group comprises 10 cases. Cleaning skin of left and right hands of each subject, naturally drying for 1 hr, and selecting 5cm on back of left and right hands²The area of (1) is used as a test area, 0.3mL of a test article is respectively smeared on the left and right hand test areas of the control groups 1-6 and the experimental groups 1-5, and the moisture content of the left and right hand test areas of each test subject is respectively measured and recorded by a skin moisture tester at each time point of 10min, 2h, 4h and 8h after smearing.

The skin care products prepared in examples 7 to 11 were used as the test products in experimental groups 1 to 5, the skin care products prepared in comparative examples 1 to 6 were used as the test products in comparative groups 1 to 6, and no substance was applied to the blank control group.

The average value of the moisture content of the tested areas of the left hand and the right hand of the tested person is taken as the moisture content test result of the skin of the tested person, and the average value of the moisture content test results of the skin of each group of tested persons is taken as the moisture content test result of the skin of the group of tested persons.

The rapid water replenishing and long-term moisturizing effects on the skin are judged by respectively comparing the significance of the difference of the skin water content before and after the skin is smeared with the test article in each group and the significance of the difference of the skin water content before and after the skin is smeared with the blank control group.

3. Results of the experiment

The results of the moisture content test of the skin of each group of subjects are shown in table 1.

Table 1 specific experimental results for each group

As can be seen from Table 1, (1) at 10min after application, the water content of the experimental groups 1-5 reaches the water content range (40% -50%) of normal skin, namely, the water-replenishing effect is rapid; 4h after the application, the water content of the experimental group can still be kept in the water content range (40-50%) of normal skin, namely the long-term moisturizing effect is achieved; even at 8h after smearing, the moisture content of the experimental groups 1-5 can still be kept equivalent to the humidity of the experimental environment;

(2) in 10min after smearing, the water content of the control group 3 is far lower than the humidity of the experimental environment, namely the control group does not have the effect of rapid water supplement; the moisture content of the control group 3 was slightly increased 2h after application, but still much lower than the humidity of the experimental environment; at 8h after application, the moisture content of the control group 3 had almost no change, but was still much lower than the humidity of the experimental environment, i.e.: has certain long-term moisturizing effect;

(3) after the application for 10min, the water content of the control group 6 reaches the water content range (40% -50%) of normal skin, namely the control group has the effect of rapidly replenishing water; after smearing, the moisture content of the 6 groups of the control group is far lower than the humidity of the experimental environment at the 2 nd hour, namely: no long-term moisturizing effect;

(4) the effects of rapid water replenishment and long-term moisture retention of the control groups 1 and 2 were slightly inferior to those of the experimental groups 1 to 5, and the effects of rapid water replenishment and long-term moisture retention of the control groups 4 and 5 were equivalent to those of the experimental groups 1 to 5.

4. Conclusion of the experiment

The skin care products prepared in examples 7 to 11 of the present invention have not only a rapid moisturizing effect but also a long-term moisturizing effect.

Experimental example 2Stability study of skin Care products of the invention

1. Purpose of experiment

The long-term stability, high temperature stability and low temperature stability of the skin care product of the present invention were studied.

2. Experimental methods

2.1 Long-term stability test method

Standing the sample at normal temperature for 6 months, and observing whether layering or sedimentation occurs.

If no obvious layering and sedimentation phenomenon exists after standing for 6 months, the long-term stability is good; otherwise, poor long-term stability is indicated.

2.2 high temperature stability test method

The sample is kept stand at 70 ℃ for 5 hours, and whether the delamination or sedimentation occurs or not is observed.

If no obvious layering and sedimentation phenomenon exists after standing for 5 hours at 70 ℃, the high-temperature stability is better; otherwise, the high temperature stability is poor.

2.3 Low temperature stability test method

The sample is kept stand for 2 hours at the temperature of minus 20 ℃ and whether the phenomenon of layering or sedimentation exists or not is observed.

If no obvious layering and sedimentation phenomenon exists after standing for 2 hours at the temperature of 20 ℃ below zero, the low-temperature stability is good; otherwise, poor low temperature stability is indicated.

2.4 test article

The skin care products prepared in examples 7 to 11 were used as the test products in experimental groups 1 to 5, and the skin care products prepared in comparative examples 1 to 17 were used as the test products in comparative groups 1 to 17.

3. Results of the experiment

The results of the experiments for each group are shown in table 2.

Table 2 specific experimental results for each group

As can be seen from Table 2, the test groups 1 to 5 (1) have not only good long-term stability but also good high-temperature stability and low-temperature stability;

(2) the control groups 1-17 had only good low temperature stability, and had poor long term stability and high temperature stability.

As can be seen from table 1 and table 2, although the effects of the rapid moisturizing and long-term moisturizing of the control groups 4 and 5 were comparable to those of the experimental groups 1 to 5, the long-term stability and high-temperature stability thereof were poor, resulting in failure to use them for preparing skin care products;

(2) the effects of rapid water replenishment and long-term moisture retention of the control groups 1 and 2 were slightly inferior to those of the experimental groups 1 to 5, and the long-term stability and high-temperature stability were poor, so that they could not be used for preparing skin care products.

4. Conclusion of the experiment

The skin care products prepared in examples 7-11 of the present invention have not only good long-term stability, but also good high temperature stability and low temperature stability.

According to the combination of the experimental example 1 and the experimental example 2, the skin care products prepared in the examples 7 to 11 of the present invention have not only the effects of rapid water replenishment and long-term moisture retention, but also good long-term stability, high-temperature stability and low-temperature stability.

Experimental example 3The safety research of the skin care product of the invention

1. Purpose of experiment

The skin care product of the present invention was investigated for its skin irritation.

2. Experimental methods

60 guinea pigs (male and female halves) were selected and divided into 6 groups of 10 animals (male and female halves), experimental groups 1-5 and control groups, respectively. About 4cm was selected in the back of each guinea pig²Performing depilation treatment on the area to be used as a tested area; the test area of each guinea pig was then smeared with 0.2mL of the corresponding test article 1 time per day for 5 consecutive days.

The skin care products prepared in examples 7 to 11 were used as the test products in experimental groups 1 to 5, respectively, and the skin care product prepared in comparative example 18 was used as the test product in the control group.

The presence or absence of skin irritation was observed in each group during the experiment.

3. Results of the experiment

In the experimental process, no skin irritation appeared in the experimental groups 1-5, and slight skin irritation appeared in the control group (such as small red spots appeared on the skin surface, and skin itching appeared in some subjects).

4. Conclusion of the experiment

The skin care products prepared in the embodiments 7 to 11 of the invention have no skin irritation and higher safety.

According to the combination of the experimental example 1 and the experimental example 2, the skin care products prepared in the embodiments 7 to 11 of the present invention have the effects of rapid water replenishment and long-term moisture retention, and also have good long-term stability, high temperature stability and low temperature stability, and have no skin irritation and high safety, and meet the requirements of skin care product preparation, so that the skin care products can be used for preparing skin care products.

It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.

Claims

1. The composition with the effects of quickly supplementing water and keeping moisture for a long time is characterized by comprising the following raw materials: 50-75 parts of dendrobium officinale extract, 15-40 parts of deodorized snake oil, 9.8-10.2 parts of span 80 and tween 80 and 0.01-0.5 part of benzalkonium chloride; the weight ratio of span 80 to tween 80 is 97: 3.

2. the composition with the effects of quickly supplementing water and preserving moisture for a long time according to claim 1, wherein the dendrobium officinale extract is prepared by the following method: pulping the stems of the dendrobium officinale, adding water with the weight of 2-10 times of the stems, stirring until the mixture is uniformly emulsified, filtering and sterilizing to obtain the dendrobium officinale drink.

3. The composition with the effects of quickly supplementing water and preserving moisture for a long time according to claim 1 or 2, wherein the deodorized snake oil is prepared by the following method:

4. Use of the composition according to any one of claims 1 to 3 for the preparation of a skin care product having both fast moisturizing and long-term moisturizing efficacy.

5. A skin care product having both rapid moisturizing and long-term moisturizing effects, comprising the composition of any one of claims 1-3.

6. The preparation method of the skin care product with the effects of quickly supplementing water and keeping moisture for a long time according to claim 5 is characterized by comprising the following steps:

7. The method for preparing the skin care product with the effects of quickly supplementing water and preserving moisture for a long time according to claim 6, wherein a step of sterilizing the dendrobium officinale extract is further included before the step of taking the dendrobium officinale extract in selected parts by weight.