CN113576974B - Lithospermum extract and lip care composition - Google Patents
Lithospermum extract and lip care composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention discloses a lithospermum extract and a lip care composition. The radix Arnebiae extract is isononyl isononanoate leaching solution of radix Arnebiae. A lip care composition comprising the following components: plant conditioning oil, antioxidant and the above radix Arnebiae extract. In the invention, the lithospermum is extracted by using isononyl isononanoate, so that the extraction effect is good, and the air permeability and the ductility of the lip care composition can be improved by adding the isononyl isononanoate into the lip care composition. The components of the lip care composition are added with the lithospermum extract and/or the grape seed oil so as to achieve the effects of mildly moistening the lips, moisturizing and nourishing the lips, relieving the lips, resisting lip wrinkles and improving the anti-allergy capability of the lips.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a lithospermum extract and a lip care composition.
Background
The skin of the lips is tender and thinner in the stratum corneum than the skin of other parts of the body, which allows the water to evaporate faster from the skin of the lips than from other parts of the body. In cold and dry autumn and winter, the lips are cracked and peeled, so that the beauty is influenced, and if the lips cannot be nursed in time, the problems of cheilitis and the like can be caused. In addition, young ladies who love beauty use the lipstick that the persistence is stronger, promote the gas color, decorate the appearance, and this kind of cosmetics that the persistence is stronger need use the makeup removing liquid to clean, if use the product of removing makeup that the cleaning capacity is stronger, then can produce great stimulation to lip skin, make the lip lose water for the production of lip line influences lip health. Therefore, lip care becomes particularly important.
The existing lip care products are possibly stained with skin metabolites in the using process so as to introduce pollution, so a proper amount of antiseptic bacteriostatic agent is generally added, but the bacteriostatic agent is generally irritant and is more easily damaged particularly for lips with thinner skin, so the development of lip products which are natural and non-irritant and have bacteriostatic ability per se becomes more important.
Disclosure of Invention
Aiming at the problem of irritation of the lips caused by the application of the existing irritation bacteriostat in lip products, the invention provides a lithospermum extract and a lip care composition, provides a preparation method of the lithospermum extract and the lip care composition and provides the application of the lithospermum extract and the lip care composition.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
an extract of radix Arnebiae is prepared from isononyl isononanoate extract of radix Arnebiae.
The invention also provides a preparation method of the lithospermum extract, which comprises the following steps:
1) adding radix Arnebiae into isononyl isononanoate, soaking, and heating to obtain mixture;
2) separating the mixture obtained in step 1) to obtain a liquid component of the extract of lithospermum erythrorhizon.
Preferably, in the preparation method of the lithospermum extract, the mass ratio of the lithospermum to isononyl isononanoate in the step 1) is 1 (20-30); further preferably, the mass ratio of the lithospermum to the isononyl isononanoate in the step 1) is 1 (22-28); still more preferably, the mass ratio of lithospermum erythrorhizon to isononyl isononanoate in the step 1) is 1: 25.
Preferably, in the preparation method of the lithospermum extract, the soaking time in the step 1) is 8-16 h; further preferably, the soaking time in the step 1) is 10-14 h; still further preferably, the soaking time in step 1) is 12 h.
Preferably, in the preparation method of the lithospermum extract, the heating temperature in the step 1) is 60-100 ℃; further preferably, the heating temperature in the step 1) is 70-90 ℃; still more preferably, the temperature of heating in step 1) is 80 ℃.
The invention also provides a lip care composition, which comprises the following components: plant conditioning oil, antioxidant and the above radix Arnebiae extract.
Preferably, the lip care composition consists of the following components in percentage by mass: 50-90% of plant conditioning grease, 0.1-1% of antioxidant, 0-30% of lithospermum extract and 0-30% of grape seed oil, wherein the mass percentages of the lithospermum extract and the grape seed oil are not 0 at the same time; further preferably, the lip care composition consists of the following components in percentage by mass: 70-90% of plant conditioning grease, 0.1-1% of antioxidant, 0-30% of lithospermum extract and 0-30% of grape seed oil, wherein the mass percentages of the lithospermum extract and the grape seed oil are not 0 at the same time; still further preferably, the lip care composition consists of the following components in percentage by mass: 70-90% of plant conditioning grease, 0.1-1% of antioxidant, 5-15% of lithospermum extract and 5-20% of grape seed oil.
In some preferred embodiments of the present invention, in the lip care composition, the mass percentage of the lithospermum extract is 5%, and the mass percentage of the grape seed oil is 15%.
Preferably, in the lip care composition, the plant conditioning oil comprises at least one of jojoba seed oil, meadowfoam seed oil, sweet almond oil, camellia oleosa seed oil, olive fruit oil and sea buckthorn seed oil; preferably, the plant conditioning oil is at least one of jojoba seed oil, chinaroot flower seed oil, sweet almond oil and camellia seed oil; still further preferably, the plant conditioning oil is jojoba seed oil, meadowfoam seed oil and sweet almond oil.
Preferably, in the lip care composition, the antioxidant is at least one of tocopherol acetate, tea polyphenol, superoxide dismutase and ascorbyl palmitate; more preferably, the antioxidant is at least one of tocopherol acetate and ascorbyl palmitate; still more preferably, the antioxidant is tocopheryl acetate.
Preferably, in the lip care composition, the antioxidant accounts for 0.2-0.8% by mass; further preferably, the antioxidant accounts for 0.3 to 0.7 percent by mass; still more preferably, the antioxidant is 0.5% by mass.
The invention also provides a preparation method of the lip care composition, which comprises the following steps: mixing the plant conditioning oil and fat, antioxidant, radix Arnebiae extract and/or grape seed oil to obtain lip protecting composition.
The invention also provides the application of the lithospermum extract in cosmetics.
The invention also provides the application of the lip care composition in lip care cosmetics.
The invention has the beneficial effects that:
isononyl isononanoate is an ester synthesized by isononanoate and isononyl alcohol through esterification reaction, is light grease, is not greasy when being used for skin, has good spreadability, overcomes the defect that natural grease is too greasy, and overcomes the defect that mineral oil has poor air permeability; the isononyl isononanoate has more methyl branched chain structures in the structure, so that the skin feel is smooth and moist, the viscosity is low, the skin is softer after being smeared with the isononyl isononanoate, the compatibility of the isononyl isononanoate and silicone oil is better, the lithospermum extract is beneficial to being used in other systems containing the silicone oil, and the application range is wide; the lip care composition has simple components and high temperature stability, the lithospermum is leached by using isononyl isononanoate, the compatibility of the isononyl isononanoate and esters is good, the active ester components in the lithospermum oil can be extracted, the extraction effect is good, and the air permeability and the ductility of the lip care composition can be improved when the lip care composition is added into the lip care composition.
The components of the lip care composition are added with the lithospermum extract and/or the grape seed oil so as to achieve the effects of mildly moistening the lips, moisturizing and nourishing the lips, relieving the lips, resisting lip wrinkles and improving the anti-allergy capability of the lips.
The lip care composition disclosed by the invention is added with the lithospermum extract, contains stable natural red pigment, is stable in color in a formula, and avoids adding pigment components.
The lithospermum extract in the lip care composition has an excellent antibacterial effect, after the lithospermum extract is added into the composition and compounded with the grape seed oil, the antibacterial effect is outstanding, bacteria introduced in the using process are effectively prevented, two kinds of grease with the antibacterial effect can replace a bacteriostatic agent, and other bacteriostatic agents with irritation are not required to be added into the composition, so that the product is relieved and has no irritation; the grape seed oil in the lip protecting composition has the effect of resisting free radicals, can reduce the stimulation of external stimulation to lip skin, and can prevent water loss caused by the damage of the external stimulation to the lip skin, so lip wrinkles can be effectively lightened.
Drawings
FIG. 1 is a graph showing the tendency of the bacteriostatic effect of lip care compositions prepared in examples 2 to 6;
FIG. 2 is a graph showing the trend of radical scavenging rates for lip care compositions prepared in examples 2-6.
Detailed Description
The present invention will be described in further detail with reference to specific examples. The starting materials, reagents or equipment used in the examples are, unless otherwise specified, either conventionally commercially available or may be obtained by methods known in the art. Unless otherwise indicated, the testing or testing methods are conventional in the art.
Example 1
The preparation method of the lithospermum extract comprises the following specific steps:
soaking 8g radix Arnebiae extract in 200g isononyl isononanoate for 12 hr, and filtering to obtain solution A. Decocting isononyl isononanoate solution A soaked with radix Arnebiae at 80 deg.C for 30min, standing, cooling, and filtering to obtain radix Arnebiae extract.
Example 2
The preparation method of the lip care composition comprises the following specific steps:
mixing jojoba seed oil 20%, meadowfoam seed oil 40%, sweet almond oil 19.5%, grape seed oil 20%, radix Arnebiae extract 0%, and tocopherol acetate 0.5% by weight, and stirring to obtain lip protecting composition.
Example 3
The preparation method of the lip care composition comprises the following specific steps:
mixing jojoba seed oil 20%, meadowfoam seed oil 40%, sweet almond oil 19.5%, grape seed oil 15%, lithospermum extract 5% and tocopherol acetate 0.5% according to mass percentage, and stirring uniformly to obtain the lip care composition.
The extract of Lithospermum erythrorhizon was prepared as in example 1.
Example 4
The preparation method of the lip care composition comprises the following specific steps:
the lip-protecting composition is prepared by mixing, by mass, jojoba seed oil 20%, meadowfoam seed oil 40%, sweet almond oil 19.5%, grape seed oil 10%, lithospermum extract 10% and tocopherol acetate 0.5%, and stirring uniformly.
The extract of Lithospermum erythrorhizon was prepared as in example 1.
Example 5
The preparation method of the lip care composition comprises the following specific steps:
the lip-protecting composition is prepared by mixing, by mass, jojoba seed oil 20%, meadowfoam seed oil 40%, sweet almond oil 19.5%, grape seed oil 5%, lithospermum extract 15% and tocopherol acetate 0.5%, and stirring uniformly.
The extract of Lithospermum erythrorhizon was prepared as in example 1.
Example 6
The preparation method of the lip care composition comprises the following specific steps:
mixing jojoba seed oil 20%, meadowfoam seed oil 40%, sweet almond oil 19.5%, grape seed oil 0%, radix Arnebiae extract 20%, and tocopherol acetate 0.5% by mass, and stirring well to obtain the lip care composition.
The extract of Lithospermum erythrorhizon was prepared as in example 1.
Performance evaluation
(1) The lip care compositions prepared in examples 2 to 6 were evaluated for bacteriostatic effects.
The lip care compositions prepared in examples 2 to 6 were added dropwise to the staphylococcus aureus solution, and a group of blank controls were set, and the other examples were the same as those of the lip care compositions. And performing OD600 test on the sample by using an enzyme-labeling instrument at intervals of 2h, 4h, 8h, 16h and 24 h. As shown in fig. 1, it can be seen from fig. 1 that examples 2 to 6 all had a certain antibacterial effect compared to the blank control group, of which example 3 showed the most excellent antibacterial effect, and example 2 had a weaker antibacterial effect than examples 3 to 6 without the addition of the comfrey extract.
(2) The lip care compositions prepared in examples 2 to 6 were evaluated for their anti-radical effects.
The specific experimental method of adopting DPPH free radical scavenging method is as follows:
dissolving 1mg of DPPH (1, 1-diphenyl-2-trinitrophenylhydrazine) in 20mL of 95 ethanol, performing ultrasonic treatment for 5min, and sufficiently shaking to obtain a DPPH test solution; 1mL of DPPH test solution was used, and the absorbance at 519nm was preferably 1.2-1.3.
And (3) taking 2mL of DPPH test solution, adding the lip-protecting composition sample prepared in the example 2-6 into the solution, gradually adding the lip-protecting composition sample at a small amount, adding the lip-protecting composition sample at a large amount, mixing the lip-protecting composition sample while adding the lip-protecting composition sample, recording the sample adding amount of the lip-protecting composition sample when the color of the solution is observed to be basically faded, wherein the sample adding amount is the maximum sample using amount, and determining the concentration setting of the test using amount according to the maximum using amount.
Adding 2mL of DPPH test solution into a small test tube, adding 1mL of 95 ethanol, fully mixing, and measuring a light absorption value A0; adding 2mL of DPPH test solution into a small test tube, adding 10-100 μ L of lip protecting composition sample liquid of example 2-6, adding 900-
TABLE 1 DPPH radical scavenging amounts
Sample liquid | 95 ethanol | DPPH test solution | Total volume |
10μL | 990μL | 2mL | 3mL |
25μL | 975μL | 2mL | 3mL |
50μL | 950μL | 2mL | 3mL |
75μL | 925μL | 2mL | 3mL |
100μL | 900μL | 2mL | 3mL |
The results of the radical clearance for examples 2-6 are shown in FIG. 2. As can be seen from the figure, example 6 has the least effective radical scavenging effect without the addition of grape seed oil; when grape seed oil is added into the formula, the lip-protecting composition shows excellent free radical scavenging capacity, unsaturated fatty acid in the grape seed oil reaches more than 70%, and the lip-protecting composition has good oxidation resistance and free radical scavenging capacity and can help improve the immunity of lip skin; generally, the grape seed oil has stronger oxidation resistance, and the higher the concentration of the grape seed oil, the stronger the oxidation resistance, and in terms of radical clearance, example 2 > example 4 > example 5, it can be proved that the higher the concentration of the grape seed oil, the stronger the oxidation resistance, but the smaller the concentration of the grape seed oil, and the radical clearance of the lip care composition is increased after a part of the lithospermum erythrorhizon extract is added in example 3, and the optimum radical clearance is shown in example 3, wherein the radical clearance reaches 87% when the addition amount is 100 μ L, and the lip care composition contains 15% of the grape seed oil and 5% of the lithospermum erythrorhizon extract.
After a small amount of lithospermum oil is added, the radical scavenging capacity of the lithospermum oil is improved, because the polysaccharide and the alkannin contained in the lithospermum extract not only can play a role in absorbing radicals, but also can promote the absorption of the grape seed oil to the radicals to a certain extent. When only a small amount of the lithospermum extract is added, the free radical scavenging efficiency of the formula is improved, because under the concentration condition, enough unsaturated fatty acid can be ensured to scavenge free radicals, and the amount of alkannin or lithospermum polysaccharide can meet the requirement of promoting the free radical absorption reaction.
(3) The lip care compositions prepared in examples 2 to 6 were evaluated for their effects in use.
25 female volunteers with 28-35 years old and deep liplines, 25 female volunteers with sensitive lips or cheilitis and 20-40 years old and 25 female volunteers with lip care habits and 20-30 years old were searched to evaluate the lip lightening effect, the lip soothing effect and the lip moisturizing effect of the lip care composition prepared in the examples 2-6 respectively. The lip care compositions prepared in examples 2 to 6 were used for two weeks in 5 groups, respectively, and after use, volunteers scored the products according to the feeling of use. The full score of each index is set to be 10 points, the average value is taken for comparison, and the evaluation results of the using effect of the obtained examples are shown in table 2.
Table 2 usage effect scoring for the examples
Categories of | Lip line fading effect | Soothing repair | Moisture retention | Moistening sensation |
Example 2 | 6 | 3 | 7 | 7 |
Example 3 | 5 | 5 | 8 | 9 |
Example 4 | 5 | 5 | 8 | 8 |
Example 5 | 3 | 3 | 7 | 9 |
Example 6 | 4 | 4 | 8 | 8 |
As can be seen from the data in Table 2, examples 2-6, among them example 3, had the best effects of soothing the skin, preserving moisture and moistening the skin. The moisturizing and water-locking performance of the lip skin is improved mainly due to the compound addition of the grape seed oil and the lithospermum extract. In the aspect of using feeling, the grape seed oil has high viscosity, when the using concentration is high, the air permeability of the skin is influenced, the lip skin is thin, the sticky feeling is strong, the conditioning effect of the lip skin is also influenced when the air permeability is poor, the sticky feeling in the skin feeling can be diluted by adding a certain amount of the lithospermum extract, the air permeability of an oil layer on the surface of the skin is improved, but if the grape seed oil is not added, the skin feeling is light and thin, the skin is difficult to moisten for a long time, and the long-acting nourishing effect is achieved.
The lithospermum extract has an excellent bacteriostatic action, and after the lithospermum extract is added into a formula and compounded with grape seed oil, the free radical removing capability of the grape seed oil improves the bacteriostatic effect of the lithospermum extract, and can prevent water loss caused by the injury of external stimulation to lip skin, so that lip wrinkles can be effectively lightened. For people with sensitive lip skin, the derivative in the lithospermum can obviously reduce the expression of IL-6 in human immortalized keratinocytes induced by TNF-alpha, thereby inhibiting inflammation and promoting histocyte repair. In addition, the lithospermum extract has a regulating effect on various cytokines, transcription factors, proinflammatory enzymes and proinflammatory mediators, and can play a role in inhibiting bacteria and preventing microbial infection while healing wounds. The lip care composition prepared by the invention has the effects of moisturizing, lip wrinkle fading and lip relaxing. In addition, the lithospermum extract contains natural pigment, so that the product has natural pink color and is favored by consumers.
Claims (7)
1. The lip care composition is characterized by comprising the following components in percentage by mass: 70-90% of plant conditioning grease, 0.1-1% of antioxidant, 5-15% of lithospermum extract and 5-20% of grape seed oil;
the radix Arnebiae extract is isononyl isononanoate leaching liquor of radix Arnebiae.
2. The lip care composition according to claim 1, wherein the lithospermum erythrorhizon extract is prepared by a method comprising the steps of:
1) adding radix Arnebiae into isononyl isononanoate, soaking, and heating to obtain mixture;
2) separating the mixture obtained in step 1) to obtain a liquid component of the lithospermum extract.
3. The lip care composition according to claim 2, wherein in the step 1), the mass ratio of the lithospermum to the isononyl isononanoate is 1 (20-30).
4. A lip care composition according to claim 2 wherein in step 1) the soaking time is from 8 to 16 hours.
5. The lip care composition according to claim 1, wherein the plant conditioning oil comprises at least one of jojoba seed oil, meadowfoam seed oil, sweet almond oil, camellia seed oil, olive oil, and sea buckthorn seed oil.
6. The lip care composition of claim 1, wherein said antioxidant is at least one of tocopheryl acetate, tea polyphenols, superoxide dismutase, ascorbyl palmitate.
7. Use of a lip care composition according to any one of claims 1 to 6 for the preparation of a lip cosmetic.
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Address after: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Applicant after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510000 No. 15, Colin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangzhou, Guangdong Applicant before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
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GR01 | Patent grant | ||
GR01 | Patent grant |