CN111407700A

CN111407700A - Skin collagen growth promoter and preparation method thereof

Info

Publication number: CN111407700A
Application number: CN202010323141.2A
Authority: CN
Inventors: 张应贤
Original assignee: Guangzhou Lakel Stem Cell Research Institute
Current assignee: Guangzhou Lakel Stem Cell Research Institute
Priority date: 2020-04-22
Filing date: 2020-04-22
Publication date: 2020-07-14

Abstract

The invention discloses a skin collagen growth promoter and a preparation method thereof, and relates to the technical field of skin care products. The right is summarized. Comprises the following components in parts by weight: 2-5 parts of glycerol glucoside, 1-5 parts of tabasheer bark extract, 0.1-1 part of European horse chestnut extract, 0.5-1.5 parts of bisabolol, 0.1-1 part of sodium hyaluronate, 3-5 parts of mung bean fermentation liquor and 15.5-35.5 parts of oil phase. The collagen growth promoter has the advantages that the glycerol glucoside is added and used as a natural cell activator, so that the effect of strong moisture retention is achieved, the skin elasticity and collagen are further enhanced, the healing of wounds and problem skin is promoted, the micro lipid vesicle wrapping technology is adopted, the activity and the absorption are facilitated, the moisture of the skin is kept, the skin aging is prevented, meanwhile, the collagen growth promoter enables the skin to tend to be neutral in the using process, the secretion state of the skin can be improved under the interaction of the water retention property and the compactness, the pores of oily skin are contracted, and the dry skin retains the moisture and is rich in elasticity.

Description

Skin collagen growth promoter and preparation method thereof

Technical Field

The invention relates to the technical field of skin care products, in particular to a skin collagen growth promoter and a preparation method thereof.

Background

With the aging, the skin becomes loose, dry and rough, the elasticity is reduced, wrinkles are increased and other aging phenomena, when the skin is damaged, the skin becomes dry and tight and cannot be relieved, the skin becomes red and hot, the symptoms are obvious when people eat irritant food, most of skin care products with strong functionality are not tolerant because the skin is fragile and sensitive, and the skin cell activity is reduced, wall collapse is caused by the reduction of the new growth speed of collagen, and chemical or physical damages in daily life, such as excessive loss or removal of sebum, use of abrasive products, abrasion or scratch, chemical substance erosion or interference, sunburn and the like, can reduce the barrier function of the skin, so that substances outside the skin can easily enter the skin.

In order to relieve the symptoms of the skin, collagen should be timely supplemented to the skin, the collagen has a strong moisturizing effect, the skin moisture-locking function can be strengthened, the skin moisture-keeping function is an important measure for moisturizing the skin connective tissue, the elasticity and the luster of the skin are influenced, the damaged skin such as acne and wrinkles can be effectively repaired, collagen accounts for one third of protein components in cells, all the great rights for controlling the health of the skin are achieved, the dermis layer tissue for controlling the elasticity of the skin is mainly formed by combining collagen fibers, elastic fibers and the like, the existing collagen supplementing mode is mostly supplemented by a collagen growth promoter, however, the existing collagen growth promoter has a general water-locking effect in the using process, and the moisture retention, elasticity and smoothness of the skin need to be improved, so that a skin collagen growth promoter and a preparation method thereof are provided to solve the problems.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides a skin collagen growth promoter and a preparation method thereof, which aim to solve the problems in the background art.

In order to achieve the purpose, the invention provides the following technical scheme: a skin collagen growth promoter comprises the following components in parts by weight: 2-5 parts of glycerol glucoside, 1-5 parts of tabasheer bark extract, 0.1-1 part of European horse chestnut extract, 0.5-1.5 parts of bisabolol, 0.1-1 part of sodium hyaluronate, 3-5 parts of mung bean fermentation liquor and 15.5-35.5 parts of oil phase.

Further optimizing the technical scheme, the oil phase comprises 5-10 parts of plukenetia volubilis seed fat, 6-12 parts of dahua cocoa seed fat, 3-8 parts of phytosterol canola oil acid ester, 0.5-3 parts of tocopherol acetate and 1-2.5 parts of lecithin.

A method for preparing skin collagen growth promoter comprises the following steps:

s1, weighing the raw materials for the first time: weighing the malus micromalus seed fat, the cocoa resin of the dahua, the low erucic acid rape oleate of the phytosterol, the tocopheryl acetate and the lecithin in the oil phase according to the proportion, and putting the materials into a beaker I for later use;

s2, preparation of gel object: adding absolute ethyl alcohol into the beaker I in the step S1 to dissolve the raw material in the beaker I in the absolute ethyl alcohol, and removing the absolute ethyl alcohol in the beaker I by using a reduced pressure evaporation mode to form a gel object for later use;

s3, weighing the raw materials for the second time: weighing glycerol glucoside, tabasheer bark extract, aesculus hippocastanum extract, bisabolol, sodium hyaluronate and mung bean fermentation liquor in proportion, and putting the mixture into a beaker II for later use;

s4, preparation of active substances: ultrasonically treating the raw material in the beaker II obtained in the step S3 in an ice-water bath to obtain a required active substance for later use;

s5, mixing the raw materials, namely wrapping the active substance obtained in the step S4 in the gel object obtained in the step S2, and uniformly mixing and stirring the active substance and the gel object for later use;

s6, preparation of a collagen growth promoter: adding 3-5 times of water by weight into the uniformly mixed and stirred raw materials in the step S5, rotating to dissolve the raw materials and fully hydrate the raw materials to prepare the required skin collagen growth promoter;

s7, filling and checking: and (5) filling and checking the collagen growth promoter prepared in the step S7, and packaging after the collagen growth promoter is checked to be qualified to obtain the required collagen growth promoter.

Further optimizing the technical scheme, the mung bean fermentation liquid contains lactobacillus/mung bean seed extract/sodium glutamate fermentation product filtrate, shaddock seed extract, calamus root extract and perilla leaf extract.

Further optimizing the technical scheme, wherein the ultrasonic time in the step S4 is 10-15 min.

Further optimizing the technical scheme, the time for fully hydrating in the step S6 is 3-5 min.

Advantageous effects

Compared with the prior art, the invention provides a skin collagen growth promoter and a preparation method thereof, and the skin collagen growth promoter has the following beneficial effects:

1. the skin collagen growth promoter and the preparation method thereof, the invention can improve the capacity of skin to absorb nutrients and moisture by adding the malus lucidus fruit palm seed fat, make the skin smooth, simultaneously form a protective film on the cell surface under the severe environment of high temperature, high pressure and dry water loss, make the skin keep delicate and smooth in the severe environment, add the seed fat of the cocoa butter of the Dahua, which is rich in lauric acid and has better water absorption effect and moisturizing performance, add the oleate of the phytosterol canola oil, which has the effect of repairing skin barrier, and simultaneously add the fermented mung bean extract of the mung bean produced by lactobacillus fermentation and biotransformation, promote the recovery and the maintenance of the dynamic balance of the skin barrier, further promote the synthesis of collagen, promote the healing of wounds and problematic skin, and directly and omnidirectionally act on the dermis of the skin by using the growth promoter, the regeneration of collagen is promoted by activating regenerative cells to accelerate the recovery of the barrier function of damaged skin, so that the effects of eliminating wrinkles and recovering the elasticity of the skin are achieved, and the skin is in a younger and fresh skin state.

2. The skin collagen growth promoter and the preparation method thereof have the advantages that the glycerol glucoside is added and used as a natural cell activator, so that the skin elasticity and collagen are enhanced, the healing of wounds and problem skin is promoted, the micro lipid vesicle wrapping technology is adopted, the activity absorption is facilitated, the skin moisture is kept, the skin aging is prevented, meanwhile, the collagen growth promoter enables the skin to tend to be neutral in the using process, the secretion state of the skin can be improved under the interaction of the water retention property and the compactness, the pores of the oily skin are contracted, and the dry skin retains the moisture, so that the skin tends to be compact and neutral, and the skin is more ruddy and compact and has high elasticity.

Drawings

FIG. 1 is a schematic flow chart of a skin collagen growth promoter and a preparation method thereof according to the present invention;

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The first embodiment is as follows: referring to fig. 1, the invention discloses a skin collagen growth promoter comprising the following components in parts by weight: 2-5 parts of glycerol glucoside, 3.5 parts of stalactite tree bark extract, 0.5 part of aesculus hippocastanum extract, 0.8 part of bisabolol, 0.5 part of sodium hyaluronate, 4.5 parts of mung bean fermentation liquor, 8 parts of plutella xylostella palm seed fat, 9 parts of macrocarpa seed fat, 5.5 parts of phytosterol low erucic acid rapeseed oil ester, 2 parts of tocopherol acetate and 2 parts of lecithin.

As a specific optimization scheme of the embodiment, the oil phase comprises 5-10 parts of plutella xylostella palm seed fat, 6-12 parts of dahua cocoa seed fat, 3-8 parts of phytosterol canola oil acid ester, 0.5-3 parts of tocopherol acetate and 1-2.5 parts of lecithin.

As a specific optimization scheme of this embodiment, the mung bean fermentation liquid comprises lactobacillus/mung bean seed extract/sodium glutamate fermentation product filtrate, shaddock seed extract, calamus root extract and perilla leaf extract.

As a specific optimization scheme of this embodiment, the ultrasound time in step S4 is 10-15 min.

As a specific optimization scheme of this embodiment, the time for the step S6 to hydrate sufficiently is 3-5 min.

Example two: referring to fig. 1, the invention discloses a skin collagen growth promoter comprising the following components in parts by weight: 5 parts of glycerol glucoside, 5 parts of a pinus punctatus bark extract, 1 part of a aesculus hippocastanum extract, 1.5 parts of bisabolol, 1 part of sodium hyaluronate, 5 parts of mung bean fermentation liquor, 10 parts of plukenetia volubilis seed fat, 12 parts of cacao seed fat, 8 parts of phytosterol low erucic acid rape oleate, 3 parts of tocopherol acetate and 2.5 parts of lecithin.

Example three: referring to fig. 1, the invention discloses a skin collagen growth promoter comprising the following components in parts by weight: 2 parts of glycerol glucoside, 1 part of a pinus punctatus bark extract, 0.1 part of a aesculus hippocastanum extract, 0.5 part of bisabolol, 0.1 part of sodium hyaluronate, 3 parts of mung bean fermentation liquor, 5 parts of plutella xylostella palm seed fat, 6 parts of dahua cocoa seed fat, 3 parts of phytosterol low erucic acid rapeseed oil ester, 0.5 part of tocopherol acetate and 1 part of lecithin.

Example 4:

examples 1-3 skin collagen growth promoting agents were prepared by the following method:

Promote the synthesis of collagen (in vitro experiment)

In vitro experiments: the aging model (Hayflick), aged dermal fibroblasts, was replicated and aged fibroblasts were treated with different concentrations of the skin collagen stimulators prepared in examples 1-3 (0.1%, 3%, 5%).

Culturing time: 72h

Table 1: amount of type I collagen synthesized by aged fibroblasts

As is clear from Table 1, the skin collagen growth promoting agent provided by the present invention can significantly increase the amount of collagen produced in aged cells, thereby improving the tension and elasticity of the skin.

Example 5

The beauty cream comprises the following components in percentage by mass: 0.1-2% of skin collagen growth promoter, 1-5% of glycerol, 0.1-0.5% of betaine, 0.1-0.3% of nicotinamide, 1-2% of buckeye resin, 5-8% of polydimethylsiloxane, 1-2% of cetostearyl alcohol, 0.5-1.5% of ethylhexyl glycerol, 0.5-2% of 1, 2-hexanediol, 0.1-0.2% of sodium acrylate/sodium acryloyldimethyl taurate copolymer, 1-5% of isohexadecane, 1-1.5% of polysorbate-800.5, and deionized water to 100%.

Control group: commercially available anti-aging cream with collagen increasing effect

Anti-aging test (in vivo test)

The test method comprises the following steps: 20 female testers of 45 years old, with normal skin aging, are applied with cosmetic cream containing 0.1%, 0.5%, 1%, 2% skin collagen growth promoter for 2 times/day for 4 weeks.

Measuring parameters: moisture retention, elasticity and smoothness of skin

Table 2: results after 28 days

As can be seen from table 2, the application of the skin collagen growth promoter prepared by the present invention in cosmetics can significantly improve the moisture retention, elasticity and smoothness of skin, so as to retain moisture of skin, make skin tend to be compact and delicate, and achieve full-elastic and full-bodied skin feel.

And (4) judging the standard: through comparison of the three embodiments, the best effect is the first embodiment, so that the selection of the first embodiment as the best embodiment, and the specific change of the amount also belongs to the protection scope of the technical scheme.

The invention has the beneficial effects that: the invention can improve the capability of skin absorbing nutrient and moisture by adding the malus lucidus fruit palm seed fat, leads the skin to be smooth, forms a protective film on the surface of cells under the severe environment of high temperature, high pressure and dry dehydration, leads the skin to keep delicate and smooth in the severe environment, adds the cocoa seed fat with big flowers, is rich in lauric acid, has better water absorption effect and moisturizing performance, adds the phytosterol, namely the low erucic acid rapeseed oleate, has the effect of repairing skin barriers, simultaneously uses the mung bean fermentation extract produced by lactobacillus fermentation and biotransformation to promote the recovery and the maintenance of the skin barriers to dynamically balance, further can promote the synthesis of collagen and promote the healing of wounds and problem skin, and the growth promoter directly acts on the dermis of the skin in all directions by activating regenerative cells to accelerate the recovery of the damaged skin barriers, the collagen regeneration is promoted, so that the effects of eliminating wrinkles, recovering the skin elasticity and presenting a younger and fresh skin state are achieved; the collagen growth promoter can improve the secretion state of the skin, shrink pores of oily skin and retain moisture of dry skin by interaction of water retention and compactness, so that the skin tends to be compact and neutral, and is more ruddy, compact and elastic.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The skin collagen growth promoter is characterized by comprising the following components in parts by weight: 2-5 parts of glycerol glucoside, 1-5 parts of tabasheer bark extract, 0.1-1 part of European horse chestnut extract, 0.5-1.5 parts of bisabolol, 0.1-1 part of sodium hyaluronate, 3-5 parts of mung bean fermentation liquor and 15.5-35.5 parts of oil phase.

2. The skin collagen growth promoter according to claim 1, wherein said oil phase comprises 5-10 parts of plutonia xylostella palm seed fat, 6-12 parts of dahua cocoa seed fat, 3-8 parts of phytosterol canola oil, 0.5-3 parts of tocopherol acetate and 1-2.5 parts of lecithin.

3. A method for preparing skin collagen growth promoter comprises the following steps:

4. The skin collagen growth promoter according to claim 3, wherein said mung bean fermentation broth comprises lactobacillus/mung bean seed extract/sodium glutamate fermentation filtrate, grapefruit seed extract, calamus root extract and perilla leaf extract.

5. The skin collagen growth promoter according to claim 3, wherein the time for the ultrasound treatment in step S4 is 10-15 min.

6. The skin collagen growth promoter according to claim 3, wherein the step S6 is performed for 3-5 min.