CN113116760A - Skin collagen proliferation promoter containing yeast flora - Google Patents
Skin collagen proliferation promoter containing yeast flora Download PDFInfo
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- CN113116760A CN113116760A CN202110556288.0A CN202110556288A CN113116760A CN 113116760 A CN113116760 A CN 113116760A CN 202110556288 A CN202110556288 A CN 202110556288A CN 113116760 A CN113116760 A CN 113116760A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention discloses a skin collagen proliferation promoter containing a yeast flora, which comprises the following components in parts by weight: 10-15 parts of yeast flora extract, 5-9 parts of avocado oil, 5-10 parts of sargassum extract, 4-8 parts of glycerol, 0.6-3.7 parts of copper peptide, 0.1-0.2 part of preservative synergist and 60-80 parts of deionized water; according to the invention, the orange peel is added, and the tartaric acid contained in the orange peel can effectively soften the horny layer of the skin, so that the elasticity of the skin is enhanced, the skin becomes smooth and tender, the skin becomes beautiful and fresh, and the effects of maintaining beauty and keeping young are achieved.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a skin collagen proliferation promoter containing a yeast flora.
Background
With the aging, the skin becomes loose, dry and rough, the elasticity is reduced, wrinkles are increased and other aging phenomena, when the skin is damaged, the skin becomes dry and tight and cannot be relieved, the skin becomes red and hot, the symptoms are obvious when people eat irritant food, most of skin care products with strong functionality are not tolerant because the skin is fragile and sensitive, and the skin cell activity is reduced, wall collapse is caused by the reduction of the new growth speed of collagen, and chemical or physical damages in daily life, such as excessive loss or removal of sebum, use of abrasive products, abrasion or scratch, chemical substance erosion or interference, sunburn and the like, can reduce the barrier function of the skin, so that substances outside the skin can easily enter the skin.
In order to relieve the symptoms of the skin, collagen is timely supplemented for the skin, the collagen has a strong moisturizing effect, can strengthen the skin water locking function, is an important assistant for moisturizing the skin connective tissue, influences the elasticity and luster of the skin, and can effectively repair the damaged skin such as acne and wrinkles, the collagen accounts for one third of protein components in cells, controls all the great rights of skin health, and controls the dermis layer tissue of the skin elasticity, and is mainly formed by combining collagen fibers, elastic fibers and the like.
However, the collagen supplement effect of the traditional skin collagen promoter in the current market is general, and multiple effects of diminishing inflammation, inhibiting bacteria, resisting aging and the like are difficult to satisfy.
Disclosure of Invention
The present invention has been made to solve the above problems of the prior art by providing a skin collagen growth promoter containing yeast flora.
In order to achieve the purpose, the invention provides the following technical scheme: a skin collagen proliferation promoter containing yeast flora comprises the following components in parts by weight: 10-15 parts of yeast flora extract, 5-9 parts of avocado oil, 5-10 parts of sargassum extract, 4-8 parts of glycerol, 0.6-3.7 parts of copper peptide, 0.1-0.2 part of preservative synergist and 60-80 parts of deionized water.
Preferably, the composition comprises the following components in parts by weight: 10 parts of yeast flora extract, 5 parts of avocado oil, 5 parts of sargassum extract, 4 parts of glycerol, 0.6 part of copper peptide, 0.1 part of preservative synergist and 60 parts of deionized water.
Preferably, the composition comprises the following components in parts by weight: 15 parts of yeast flora extract, 9 parts of avocado oil, 10 parts of sargassum extract, 8 parts of glycerol, 3.7 parts of copper peptide, 0.2 part of preservative synergist and 80 parts of deionized water.
Preferably, the preservative synergist is one or more of hexanediol, pentanediol and octanediol.
Preferably, the yeast flora extract comprises the following components in parts by weight: 5-10 parts of orange peel, 5-10 parts of orange flesh, 0.3-3.6 parts of red pepper, 1.3-2.7 parts of dandelion, 2.3-4.6 parts of honeysuckle, 3-6 parts of wild chrysanthemum flower, 5-15 parts of Chinese violet and 10-30 parts of green tea.
Preferably, the preparation method of the yeast flora extract comprises the following steps:
(1) cleaning and drying orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea, then crushing and sieving with a 40-mesh sieve to obtain orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea powder;
(2) uniformly mixing the orange peel, the orange flesh, the red pepper, the dandelion, the honeysuckle, the wild chrysanthemum flower, the Chinese violet and the green tea powder obtained in the step (1), adding purified water, mixing according to the water-material ratio of (30-40) to 1, and then sterilizing for 20-30 minutes to obtain a traditional Chinese medicine fermentation culture medium;
(3) inoculating yeast to the Chinese medicinal fermentation medium at 10% of the inoculation amount, and rotating at a table rotation speed of 120r min at a fermentation temperature of 30 deg.C-1Then, carrying out shake culture for 48h to obtain fermentation liquor;
(4) centrifuging the fermentation liquor obtained in the step (3) at a super high speed, and filtering to remove cell walls and insoluble molecules; the obtained filtrate is subjected to single-effect concentration, activated carbon decoloration and odor removal to obtain the yeast flora extract.
Preferably, in step (3), the yeast strain used is a Saccharomycopsis fibuligera, and the cell concentration is 1X 109 CFU.mL-1。
Preferably, the preparation method of the extract of the alga of the class rhodophyceae comprises the following steps: placing the alga of the class Rhodophyceae in water for hydrolysis for 1-3 hours, wherein the weight ratio of the alga of the class Rhodophyceae to the water is 0.5-2: 10, and the hydrolysis temperature is 110-130 ℃; filtering for the first time, adding sucrose into the filtrate for the first deodorization, wherein the weight ratio of the filtrate to the sucrose is 1: 0.005-0.01; and (3) filtering for the second time, cooling the filtrate to 40-50 ℃, adding active carbon for carrying out secondary fishy smell removal, wherein the weight ratio of the filtrate to the active carbon is 1: 0.005-0.05, concentrating until the relative density is 1.15-1.20, and sterilizing to obtain the sargassum extract.
A method for preparing skin collagen proliferation promoter containing yeast flora comprises the following steps:
s1, weighing the raw materials according to the proportion, sequentially adding the yeast flora extract, the rhodophyceae seaweed extract, the copper peptide and the deionized water into a water phase pot, stirring and heating to 60-70 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture A;
s2, sequentially adding avocado oil and glycerol into an oil phase pot, stirring and heating to 75-85 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture B;
s3, filtering the mixture A in the water phase pot in the step S1 through a 170-200-mesh sieve, pumping the mixture A into an emulsifying pot, pumping the mixture B in the oil phase pot in the step S2 into the emulsifying pot, and stirring for 20-30 minutes at the temperature of 70-75 ℃ to obtain a mixture C;
s4, cooling the mixture C in the emulsifying pot in the step S3 to 40-45 ℃, adding the preservative synergist, and stirring for 20-30 minutes under the condition of heat preservation;
s5, stirring and cooling the material obtained in the step S4 to room temperature, stopping stirring and discharging to obtain the skin collagen proliferation promoter;
s6, filling and inspecting the skin collagen proliferation promoter prepared in the step S5, and packaging after the skin collagen proliferation promoter is inspected to be qualified to obtain the required skin collagen proliferation promoter.
Compared with the prior art, the invention has the beneficial effects that:
1. the invention adds the orange peel which is rich in fruit acid and can effectively soften the horny layer of the skin, thereby enhancing the elasticity of the skin, leading the skin to become smooth and tender, glowing from inside to outside and playing the role of beautifying and nourishing the face, the added orange flesh can play the roles of whitening and cleaning the skin, removing color spots, tightening the skin, moistening the skin, eliminating fatigue and resisting skin aging, the added avocado oil can clean the deep layer of the skin, eliminate wrinkles, fading black spots and freckles, simultaneously be absorbed by the skin into the bottom layer of the skin to achieve the effect of maintenance, can effectively lock water, help the reconstruction of body cells, promote the growth of connective tissues in the skin and the activation of a defense tissue system, and the red pepper is added and contains rich vitamin C and carotene (vitamin A precursor), and the added seaweed extract of red algae, is rich in components such as carrageenan, has the functions of clearing away heat and toxic materials, resisting bacteria and diminishing inflammation, can cover the surface of damaged skin for a long time, and is beneficial to skin repair.
2. According to the invention, through the added green tea, the theanine in the green tea has stronger oxidation resistance, the oxidation resistance of the theanine is 4-6 times of that of artificial synthetic antioxidants BHT and BHA, 6-7 times of that of vitamin E and 5-10 times of that of vitamin C, and the theanine in the green tea has pure natural astringency and bacteriostatic effects, so that the skin can be cleaned, and the skin can be protected from being damaged.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A skin collagen proliferation promoter containing yeast flora comprises the following components in parts by weight: 10 parts of yeast flora extract, 5 parts of avocado oil, 5 parts of sargassum extract, 4 parts of glycerol, 0.6 part of copper peptide, 0.1 part of preservative synergist and 60 parts of deionized water.
Wherein, the preservative synergist is one or more of hexanediol, pentanediol and octanediol.
Wherein the yeast flora extract comprises the following components in parts by weight: 5 parts of orange peel, 5 parts of orange flesh, 0.3 part of red pepper, 1.3 parts of dandelion, 2.3 parts of honeysuckle, 3 parts of wild chrysanthemum flower, 5 parts of Chinese violet and 10 parts of green tea.
The preparation method of the yeast flora extract comprises the following steps:
(1) cleaning and drying orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea, then crushing and sieving with a 40-mesh sieve to obtain orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea powder;
(2) uniformly mixing the orange peel, the orange flesh, the red pepper, the dandelion, the honeysuckle, the wild chrysanthemum flower, the Chinese violet and the green tea powder obtained in the step (1), adding purified water, mixing according to the water-material ratio of (30-40) to 1, and then sterilizing for 20-30 minutes to obtain a traditional Chinese medicine fermentation culture medium;
(3) inoculating yeast to the Chinese medicinal fermentation medium at 10% of the inoculation amount, and rotating at a table rotation speed of 120r min at a fermentation temperature of 30 deg.C-1Then, carrying out shake culture for 48h to obtain fermentation liquor;
(4) centrifuging the fermentation liquor obtained in the step (3) at a super high speed, and filtering to remove cell walls and insoluble molecules; the obtained filtrate is subjected to single-effect concentration, activated carbon decoloration and odor removal to obtain the yeast flora extract.
Wherein, in the step (3), the adopted yeast strain is the saccule-covering yeast, and the thallus concentration is 1 multiplied by 109 CFU.mL-1。
Wherein the preparation method of the extract of the seaweed of the class Rhodophyceae comprises the following steps: placing the alga of the class Rhodophyceae in water for hydrolysis for 1-3 hours, wherein the weight ratio of the alga of the class Rhodophyceae to the water is 0.5-2: 10, and the hydrolysis temperature is 110-130 ℃; filtering for the first time, adding sucrose into the filtrate for the first deodorization, wherein the weight ratio of the filtrate to the sucrose is 1: 0.005-0.01; and (3) filtering for the second time, cooling the filtrate to 40-50 ℃, adding active carbon for carrying out secondary fishy smell removal, wherein the weight ratio of the filtrate to the active carbon is 1: 0.005-0.05, concentrating until the relative density is 1.15-1.20, and sterilizing to obtain the sargassum extract.
A method for preparing skin collagen proliferation promoter containing yeast flora comprises the following steps:
s1, weighing the raw materials according to the proportion, sequentially adding the yeast flora extract, the rhodophyceae seaweed extract, the copper peptide and the deionized water into a water phase pot, stirring and heating to 60-70 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture A;
s2, sequentially adding avocado oil and glycerol into an oil phase pot, stirring and heating to 75-85 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture B;
s3, filtering the mixture A in the water phase pot in the step S1 through a 170-200-mesh sieve, pumping the mixture A into an emulsifying pot, pumping the mixture B in the oil phase pot in the step S2 into the emulsifying pot, and stirring for 20-30 minutes at the temperature of 70-75 ℃ to obtain a mixture C;
s4, cooling the mixture C in the emulsifying pot in the step S3 to 40-45 ℃, adding the preservative synergist, and stirring for 20-30 minutes under the condition of heat preservation;
s5, stirring and cooling the material obtained in the step S4 to room temperature, stopping stirring and discharging to obtain the skin collagen proliferation promoter;
s6, filling and inspecting the skin collagen proliferation promoter prepared in the step S5, and packaging after the skin collagen proliferation promoter is inspected to be qualified to obtain the required skin collagen proliferation promoter.
Example 2
A skin collagen proliferation promoter containing yeast flora comprises the following components in parts by weight: 12 parts of yeast flora extract, 7 parts of avocado oil, 7 parts of sargassum extract, 6 parts of glycerol, 2.5 parts of copper peptide, 0.15 part of preservative synergist and 68 parts of deionized water.
Wherein the yeast flora extract comprises the following components in parts by weight: 7 parts of orange peel, 7 parts of orange flesh, 2.5 parts of red pepper, 1.6 parts of dandelion, 3.2 parts of honeysuckle, 4 parts of wild chrysanthemum flower, 7 parts of Chinese violet and 18 parts of green tea.
The preparation method of the yeast flora extract comprises the following steps:
(1) cleaning and drying orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea, then crushing and sieving with a 40-mesh sieve to obtain orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea powder;
(2) uniformly mixing the orange peel, the orange flesh, the red pepper, the dandelion, the honeysuckle, the wild chrysanthemum flower, the Chinese violet and the green tea powder obtained in the step (1), adding purified water, mixing according to the water-material ratio of (30-40) to 1, and then sterilizing for 20-30 minutes to obtain a traditional Chinese medicine fermentation culture medium;
(3) inoculating yeast to the Chinese medicinal fermentation medium at 10% of the inoculation amount, and rotating at a table rotation speed of 120r min at a fermentation temperature of 30 deg.C-1Then, carrying out shake culture for 48h to obtain fermentation liquor;
(4) centrifuging the fermentation liquor obtained in the step (3) at a super high speed, and filtering to remove cell walls and insoluble molecules; the obtained filtrate is subjected to single-effect concentration, activated carbon decoloration and odor removal to obtain the yeast flora extract.
A method for preparing skin collagen proliferation promoter containing yeast flora comprises the following steps:
s1, weighing the raw materials according to the proportion, sequentially adding the yeast flora extract, the rhodophyceae seaweed extract, the copper peptide and the deionized water into a water phase pot, stirring and heating to 60-70 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture A;
s2, sequentially adding avocado oil and glycerol into an oil phase pot, stirring and heating to 75-85 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture B;
s3, filtering the mixture A in the water phase pot in the step S1 through a 170-200-mesh sieve, pumping the mixture A into an emulsifying pot, pumping the mixture B in the oil phase pot in the step S2 into the emulsifying pot, and stirring for 20-30 minutes at the temperature of 70-75 ℃ to obtain a mixture C;
s4, cooling the mixture C in the emulsifying pot in the step S3 to 40-45 ℃, adding the preservative synergist, and stirring for 20-30 minutes under the condition of heat preservation;
s5, stirring and cooling the material obtained in the step S4 to room temperature, stopping stirring and discharging to obtain the skin collagen proliferation promoter;
s6, filling and inspecting the skin collagen proliferation promoter prepared in the step S5, and packaging after the skin collagen proliferation promoter is inspected to be qualified to obtain the required skin collagen proliferation promoter.
Example 3
A skin collagen proliferation promoter containing yeast flora comprises the following components in parts by weight: 14 parts of yeast flora extract, 8 parts of avocado oil, 8 parts of sargassum extract, 6 parts of glycerol, 3.1 parts of copper peptide, 0.17 part of preservative synergist and 76 parts of deionized water.
Wherein the yeast flora extract comprises the following components in parts by weight: 9 parts of orange peel, 9 parts of orange flesh, 3.1 parts of red pepper, 2.1 parts of dandelion, 3.8 parts of honeysuckle, 5 parts of wild chrysanthemum flower, 11 parts of Chinese violet and 26 parts of green tea.
The preparation method of the yeast flora extract comprises the following steps:
(1) cleaning and drying orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea, then crushing and sieving with a 40-mesh sieve to obtain orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea powder;
(2) uniformly mixing the orange peel, the orange flesh, the red pepper, the dandelion, the honeysuckle, the wild chrysanthemum flower, the Chinese violet and the green tea powder obtained in the step (1), adding purified water, mixing according to the water-material ratio of (30-40) to 1, and then sterilizing for 20-30 minutes to obtain a traditional Chinese medicine fermentation culture medium;
(3) inoculating yeast to the Chinese medicinal fermentation medium at 10% of the inoculation amount, and rotating at a table rotation speed of 120r min at a fermentation temperature of 30 deg.C-1Then, carrying out shake culture for 48h to obtain fermentation liquor;
(4) centrifuging the fermentation liquor obtained in the step (3) at a super high speed, and filtering to remove cell walls and insoluble molecules; the obtained filtrate is subjected to single-effect concentration, activated carbon decoloration and odor removal to obtain the yeast flora extract.
A method for preparing skin collagen proliferation promoter containing yeast flora comprises the following steps:
s1, weighing the raw materials according to the proportion, sequentially adding the yeast flora extract, the rhodophyceae seaweed extract, the copper peptide and the deionized water into a water phase pot, stirring and heating to 60-70 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture A;
s2, sequentially adding avocado oil and glycerol into an oil phase pot, stirring and heating to 75-85 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture B;
s3, filtering the mixture A in the water phase pot in the step S1 through a 170-200-mesh sieve, pumping the mixture A into an emulsifying pot, pumping the mixture B in the oil phase pot in the step S2 into the emulsifying pot, and stirring for 20-30 minutes at the temperature of 70-75 ℃ to obtain a mixture C;
s4, cooling the mixture C in the emulsifying pot in the step S3 to 40-45 ℃, adding the preservative synergist, and stirring for 20-30 minutes under the condition of heat preservation;
s5, stirring and cooling the material obtained in the step S4 to room temperature, stopping stirring and discharging to obtain the skin collagen proliferation promoter;
s6, filling and inspecting the skin collagen proliferation promoter prepared in the step S5, and packaging after the skin collagen proliferation promoter is inspected to be qualified to obtain the required skin collagen proliferation promoter.
Example 4
A skin collagen proliferation promoter containing yeast flora comprises the following components in parts by weight: 15 parts of yeast flora extract, 9 parts of avocado oil, 10 parts of sargassum extract, 8 parts of glycerol, 3.7 parts of copper peptide, 0.2 part of preservative synergist and 80 parts of deionized water.
Wherein the yeast flora extract comprises the following components in parts by weight: 10 parts of orange peel, 10 parts of orange flesh, 3.6 parts of red pepper, 2.7 parts of dandelion, 4.6 parts of honeysuckle, 6 parts of wild chrysanthemum flower, 15 parts of Chinese violet and 30 parts of green tea.
The preparation method of the yeast flora extract comprises the following steps:
(1) cleaning and drying orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea, then crushing and sieving with a 40-mesh sieve to obtain orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea powder;
(2) uniformly mixing the orange peel, the orange flesh, the red pepper, the dandelion, the honeysuckle, the wild chrysanthemum flower, the Chinese violet and the green tea powder obtained in the step (1), adding purified water, mixing according to the water-material ratio of (30-40) to 1, and then sterilizing for 20-30 minutes to obtain a traditional Chinese medicine fermentation culture medium;
(3) inoculating yeast to the Chinese medicinal fermentation medium at 10% of the inoculation amount, and rotating at a table rotation speed of 120r min at a fermentation temperature of 30 deg.C-1Then, carrying out shake culture for 48h to obtain fermentation liquor;
(4) centrifuging the fermentation liquor obtained in the step (3) at a super high speed, and filtering to remove cell walls and insoluble molecules; the obtained filtrate is subjected to single-effect concentration, activated carbon decoloration and odor removal to obtain the yeast flora extract.
A method for preparing skin collagen proliferation promoter containing yeast flora comprises the following steps:
s1, weighing the raw materials according to the proportion, sequentially adding the yeast flora extract, the rhodophyceae seaweed extract, the copper peptide and the deionized water into a water phase pot, stirring and heating to 60-70 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture A;
s2, sequentially adding avocado oil and glycerol into an oil phase pot, stirring and heating to 75-85 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture B;
s3, filtering the mixture A in the water phase pot in the step S1 through a 170-200-mesh sieve, pumping the mixture A into an emulsifying pot, pumping the mixture B in the oil phase pot in the step S2 into the emulsifying pot, and stirring for 20-30 minutes at the temperature of 70-75 ℃ to obtain a mixture C;
s4, cooling the mixture C in the emulsifying pot in the step S3 to 40-45 ℃, adding the preservative synergist, and stirring for 20-30 minutes under the condition of heat preservation;
s5, stirring and cooling the material obtained in the step S4 to room temperature, stopping stirring and discharging to obtain the skin collagen proliferation promoter;
s6, filling and inspecting the skin collagen proliferation promoter prepared in the step S5, and packaging after the skin collagen proliferation promoter is inspected to be qualified to obtain the required skin collagen proliferation promoter.
Test example 1
Promote the synthesis of collagen (in vitro experiment)
In vitro experiments: the aging model (Hayflick), aged dermal fibroblasts, aged fibroblasts (0.1%, 3%, 5%) were treated with the skin collagen proliferation promoter prepared in examples 1 to 4 and the comparative example.
Culturing time: 72h
The comparative example is a skin collagen growth promoter on the market
Table 1: amount of type I collagen synthesized by aged fibroblasts
| Amount of collagen (ng/ml) | Growth rate (%) | |
| Comparative example | 536 | +6％ |
| Example 1 | 686 | +36％ |
| Example 2 | 836 | +57％ |
| Example 3 | 856 | +68％ |
| Example 4 | 769 | +45％ |
From the various embodiments above, it is known that: the skin collagen proliferation promoter provided by the invention can obviously improve the generation amount of collagen in aged cells, thereby improving the tension and elasticity of skin.
Test example 2
Control group: commercially available anti-aging cream with collagen increasing effect
Anti-aging test (in vivo test)
The test method comprises the following steps: 20 female testers of 45 years old, with normal skin aging, are applied with cosmetic cream containing 0.1%, 0.5%, 1%, 2% skin collagen growth promoter for 2 times/day for 4 weeks.
Measuring parameters: moisture retention, elasticity and smoothness of skin
Table 2: results after 28 days
From the various embodiments above, it is known that: the skin collagen growth promoter prepared by the invention is applied to cosmetics, can obviously improve the moisture retention, elasticity and smoothness of skin, enables the skin to retain moisture, enables the skin to tend to be compact and delicate, and realizes elastic and full skin feel.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. A skin collagen proliferation promoter containing a yeast flora, characterized in that: comprises the following components in parts by weight: 10-15 parts of yeast flora extract, 5-9 parts of avocado oil, 5-10 parts of sargassum extract, 4-8 parts of glycerol, 0.6-3.7 parts of copper peptide, 0.1-0.2 part of preservative synergist and 60-80 parts of deionized water.
2. The skin collagen production promoter according to claim 1, wherein the collagen production promoter comprises a yeast group: comprises the following components in parts by weight: 10 parts of yeast flora extract, 5 parts of avocado oil, 5 parts of sargassum extract, 4 parts of glycerol, 0.6 part of copper peptide, 0.1 part of preservative synergist and 60 parts of deionized water.
3. The skin collagen production promoter according to claim 1, wherein the collagen production promoter comprises a yeast group: comprises the following components in parts by weight: 15 parts of yeast flora extract, 9 parts of avocado oil, 10 parts of sargassum extract, 8 parts of glycerol, 3.7 parts of copper peptide, 0.2 part of preservative synergist and 80 parts of deionized water.
4. The skin collagen production promoter according to claim 1, wherein the collagen production promoter comprises a yeast group: the preservative synergist is one or more of hexanediol, pentanediol and octanediol.
5. The skin collagen production promoter according to claim 1, wherein the collagen production promoter comprises a yeast group: the yeast flora extract comprises the following components in parts by weight: 5-10 parts of orange peel, 5-10 parts of orange flesh, 0.3-3.6 parts of red pepper, 1.3-2.7 parts of dandelion, 2.3-4.6 parts of honeysuckle, 3-6 parts of wild chrysanthemum flower, 5-15 parts of Chinese violet and 10-30 parts of green tea.
6. The skin collagen production promoter according to claim 1, wherein the collagen production promoter comprises a yeast group: the preparation method of the yeast flora extract comprises the following steps:
(1) cleaning and drying orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea, then crushing and sieving with a 40-mesh sieve to obtain orange peel, orange flesh, red pepper, dandelion, honeysuckle, wild chrysanthemum, Chinese violet and green tea powder;
(2) uniformly mixing the orange peel, the orange flesh, the red pepper, the dandelion, the honeysuckle, the wild chrysanthemum flower, the Chinese violet and the green tea powder obtained in the step (1), adding purified water, mixing according to the water-material ratio of (30-40) to 1, and then sterilizing for 20-30 minutes to obtain a traditional Chinese medicine fermentation culture medium;
(3)、inoculating yeast to the Chinese medicinal fermentation medium at 10% of inoculation amount, and rotating at shaking table speed of 120r min at fermentation temperature of 30 deg.C-1Then, carrying out shake culture for 48h to obtain fermentation liquor;
(4) centrifuging the fermentation liquor obtained in the step (3) at a super high speed, and filtering to remove cell walls and insoluble molecules; the obtained filtrate is subjected to single-effect concentration, activated carbon decoloration and odor removal to obtain the yeast flora extract.
7. The skin collagen production promoter according to claim 1, wherein the collagen production promoter comprises a yeast group: in the step (3), the yeast strain used is the Saccharomycopsis fibuligera with the thallus concentration of 1 × 109 CFU.mL-1。
8. The skin collagen production promoter according to claim 1, wherein the collagen production promoter comprises a yeast group: the preparation method of the extract of the seaweed of the class Rhodophyceae comprises the following steps: placing the alga of the class Rhodophyceae in water for hydrolysis for 1-3 hours, wherein the weight ratio of the alga of the class Rhodophyceae to the water is 0.5-2: 10, and the hydrolysis temperature is 110-130 ℃; filtering for the first time, adding sucrose into the filtrate for the first deodorization, wherein the weight ratio of the filtrate to the sucrose is 1: 0.005-0.01; and (3) filtering for the second time, cooling the filtrate to 40-50 ℃, adding active carbon for carrying out secondary fishy smell removal, wherein the weight ratio of the filtrate to the active carbon is 1: 0.005-0.05, concentrating until the relative density is 1.15-1.20, and sterilizing to obtain the sargassum extract.
9. The method for producing a skin collagen production promoter containing yeast bacteria according to any one of claims 1 to 8, wherein: the method comprises the following steps:
s1, weighing the raw materials according to the proportion, sequentially adding the yeast flora extract, the rhodophyceae seaweed extract, the copper peptide and the deionized water into a water phase pot, stirring and heating to 60-70 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture A;
s2, sequentially adding avocado oil and glycerol into an oil phase pot, stirring and heating to 75-85 ℃, preserving heat and stirring for 20-30 minutes to obtain a mixture B;
s3, filtering the mixture A in the water phase pot in the step S1 through a 170-200-mesh sieve, pumping the mixture A into an emulsifying pot, pumping the mixture B in the oil phase pot in the step S2 into the emulsifying pot, and stirring for 20-30 minutes at the temperature of 70-75 ℃ to obtain a mixture C;
s4, cooling the mixture C in the emulsifying pot in the step S3 to 40-45 ℃, adding the preservative synergist, and stirring for 20-30 minutes under the condition of heat preservation;
s5, stirring and cooling the material obtained in the step S4 to room temperature, stopping stirring and discharging to obtain the skin collagen proliferation promoter;
s6, filling and inspecting the skin collagen proliferation promoter prepared in the step S5, and packaging after the skin collagen proliferation promoter is inspected to be qualified to obtain the required skin collagen proliferation promoter.
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|---|---|---|---|---|
| JP2007099625A (en) * | 2005-09-30 | 2007-04-19 | Ryukyu Bio Resource Kaihatsu:Kk | Skin fibroblast growth promoter |
| CN107737369A (en) * | 2017-11-29 | 2018-02-27 | 桂林华诺威生物科技有限公司 | Collagen Skin diaphragm |
| CN111407700A (en) * | 2020-04-22 | 2020-07-14 | 广州市拉凯尔干细胞研究所 | Skin collagen growth promoter and preparation method thereof |
| CN112156043A (en) * | 2020-10-19 | 2021-01-01 | 张兴富 | Cosmetic composition containing yeast fermentation product extract and preparation method thereof |
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2021
- 2021-05-21 CN CN202110556288.0A patent/CN113116760A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007099625A (en) * | 2005-09-30 | 2007-04-19 | Ryukyu Bio Resource Kaihatsu:Kk | Skin fibroblast growth promoter |
| CN107737369A (en) * | 2017-11-29 | 2018-02-27 | 桂林华诺威生物科技有限公司 | Collagen Skin diaphragm |
| CN111407700A (en) * | 2020-04-22 | 2020-07-14 | 广州市拉凯尔干细胞研究所 | Skin collagen growth promoter and preparation method thereof |
| CN112156043A (en) * | 2020-10-19 | 2021-01-01 | 张兴富 | Cosmetic composition containing yeast fermentation product extract and preparation method thereof |
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