CN113456541A

CN113456541A - Acne-removing composition, application thereof and acne-removing nursing membrane

Info

Publication number: CN113456541A
Application number: CN202010236169.2A
Authority: CN
Inventors: 戴跃锋; 颜少慰; 何广文; 钱景茹; 闫加雷
Original assignee: Hunan Yujia Cosmetics Manufacturing Co ltd
Current assignee: Hunan Yujia Cosmetics Manufacturing Co ltd
Priority date: 2020-03-30
Filing date: 2020-03-30
Publication date: 2021-10-01

Abstract

The invention relates to an acne-removing composition, application thereof and an acne-removing nursing membrane, wherein the acne-removing composition comprises the following components in parts by weight: embroidery thread1-5 parts of chrysanthemum extract, 1-5 parts of mandelic acid and lysozyme (2-100) x 10^‑3The traditional Chinese medicine composition comprises, by weight, 1-5 parts of hemp leaf extract, 0.2-1 part of phytosphingosine and 1-3 parts of clerodendranthus spicatus extract. The acne-removing composition disclosed by the invention selects the specific six components and controls the specific mixture ratio, so that the acne-removing problem is solved from three dimensions of oil control and cutin metabolism regulation before the pox outbreak, bacteriostasis and inflammation diminishing angle in the pox outbreak, barrier repair after the pox outbreak and pigmentation prevention, and the acne-removing composition has a good acne-removing effect. The acne-removing composition is particularly suitable for acne-removing care of the skin of the forehead, the chin and the like of the human face.

Description

Acne-removing composition, application thereof and acne-removing nursing membrane

Technical Field

The invention relates to the technical field of cosmetics, in particular to an acne-removing composition, application thereof and an acne-removing nursing membrane.

Background

Acne is a chronic inflammatory lesion of the hair follicles, sebaceous glands associated with sebum metabolism; commonly called whelk, acne and pimple, and ancient called face sore and acne; is a common disease and a frequently encountered disease of dermatology. The clinical manifestations of acne are white head, blackhead, comedo, pimple, pustule, nodule, cyst, depression or hypertrophic scar, which are frequently found on the abundant sebaceous glands of face, neck, back and the like of patients. Acne commonly occurs in adolescents, but it is still prevalent in adults. Acne, although not life threatening, seriously affects the personal appearance and self-esteem of the patient and even causes psychological illnesses, resulting in sub-health of the patient. The results of domestic and foreign research show that acne can cause the patients to have poor mood such as depressed mood, anxiety, depression, mental stress and the like, and therefore, serious psychosocial problems are caused.

The pathogenesis of acne is complex, and the occurrence and development of acne are mainly considered to be related to factors such as large secretion of sebum under the action of androgen, change of sebum components, abnormal keratinization of pilosebaceous vessels, planting of propionibacterium acnes, inflammatory reaction, emotional factors, heredity, dietary habits, environmental factors, immunity and the like.

Along with the development of social economy and the increasing demand of people for good life, the awareness of skin care and beauty of people is gradually improved, and the effectiveness of cosmetics is more and more concerned by consumers besides safety.

The mask is taken as a common cosmetic formulation, is convenient to carry and use, has obvious effect, better and better market prospect and larger share in the field of cosmetics. The facial mask is a product with enhanced efficacy in skin care products, the content of active ingredients is generally higher than that of other skin care products, and the active ingredients are required to be more easily absorbed by the skin due to the particularity of the formula and the using method of the facial mask. Because people pay more and more attention to skin care, more and more attention to various problems of the skin, and then the demand on the facial mask with the efficacy of removing acnes and the like is larger and larger.

Disclosure of Invention

Based on the above, there is a need for an acne-removing composition capable of effectively removing acne, an application thereof and an acne-removing nursing membrane.

The invention provides an acne-removing composition which comprises the following components in parts by weight:

in one embodiment, the composition comprises the following components in parts by weight:

in one embodiment, the weight ratio of the spiraea ulmaria extract, the mandelic acid, the lysozyme, the cannabis leaf extract, the phytosphingosine and the clerodendranthus spicatus extract is 1 (0.9-1.1): (1-2) × 10^-3:(0.6～1):(0.15～0.2):(0.6～1)。

In one embodiment, the following components are included:

in another aspect, the invention provides the use of the acne-removing composition described in any one of the above in the preparation of a skin care product.

In another aspect, the invention provides a skin care product, which comprises the acne removing composition as described in any one of the above and a solvent or matrix acceptable in the skin care product.

The invention also provides an acne-removing nursing membrane, which comprises a wafer and an acne-removing composition dispersed in the wafer, wherein the acne-removing composition is the acne-removing composition described in any one of the above items; wherein the wafer contains pullulanase.

In one embodiment, the wafer further comprises pectin, carob bean gum, and carrageen.

In one embodiment, the wafer further comprises a preservative, wherein the preservative is PHL.

In one embodiment, the acne-removing care film comprises the following components in parts by weight:

the invention also provides a preparation method of the acne-removing nursing membrane, which comprises the following steps:

providing the acne removing composition in the acne removing nursing membrane and raw materials required by the wafer;

mixing the acne-removing composition and the raw materials required by the wafer to obtain a material body;

and (4) forming the material body to obtain the acne-removing nursing membrane.

providing the acne-removing composition in the acne-removing nursing membrane and raw materials required by the wafer;

mixing and dissolving the components of the raw materials required by the wafer except the preservative with water at 70-80 ℃; cooling to 40-45 ℃, adding the preservative and the raw materials of the acne-removing composition, and mixing to obtain a material body;

and (4) forming the material body to obtain the acne-removing nursing membrane.

In one embodiment, the raw materials comprise the following components in percentage by weight: 8 to 12 percent of pullulanase, 0.5 to 1.5 percent of preservative, 0.5 to 1.5 percent of pectin, 0.2 to 0.5 percent of carob bean gum, 0.5 to 1 percent of crinkle carrageenan, 1 to 5 percent of spiraea ulmaria extract, 1 to 5 percent of mandelic acid, 20 to 1000ppm of lysozyme, 1 to 5 percent of hemp leaf extract, 0.2 to 1 percent of phytosphingosine, 1 to 3 percent of clerodendranthus spicatus extract and 65 to 84 percent of water.

The technical scheme of the invention has the following advantages:

the acne-removing composition disclosed by the invention selects the specific six components and controls the specific mixture ratio, so that the acne-removing problem is solved from three dimensions of oil control and cutin metabolism regulation before the pox outbreak, bacteriostasis and inflammation diminishing angle in the pox outbreak, barrier repair after the pox outbreak and pigmentation prevention, and the acne-removing composition has a good acne-removing effect. The acne-removing composition is particularly suitable for acne-removing care of the skin of the forehead, the chin and the like of the human face.

The acne-removing care film sheet provided by the invention disperses the acne-removing composition in the wafer taking the pullulanase for teething as a framework. In the using process, the wafer and the functional components of the acne-removing nursing membrane are dissolved under the action of water, moisturizing water or other facial mask liquid and then are directly absorbed by the skin, so that the acne-removing nursing membrane does not have the problem of unstable components caused by compatibility of the functional components, and the development time for improving the stability of the formula can be effectively saved. The acne-removing composition is used as an effective component, the concentration of the acne-removing composition can be set to any required concentration, for example, high concentration, and compared with traditional facial mask liquid with larger dosage, the acne-removing composition can be reduced in dosage and improve the utilization rate of the acne-removing composition.

Particularly, the acne-removing nursing membrane can be suitable for acne-removing nursing, then penetrants such as water, moisturizing water or other mask liquids are added, and the strong-effect fine-grain-removing components carried in the wafer act on the face under the action of the penetrants, so that the dissolution and absorption of the acne-removing nursing membrane can be effectively promoted, and the problem of acne can be solved in a centralized manner.

Drawings

FIG. 1 is a graph comparing the reduction in skin moisture loss for each control and each example;

FIG. 2 is a comparison of the reduction of skin erythema for each control and each example;

FIG. 3 is a graph comparing the reduction of melanin in the skin for each control and each example;

figure 4 is a plot of the rate of skin lesion regression for each control and each example.

Detailed Description

In order that the invention may be more fully understood, a more particular description of the invention will now be rendered by reference to specific embodiments thereof that are illustrated in the appended drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

The mechanism of action of conventional masks generally includes three aspects: firstly, the facial mask keeps full nutrition and moisture of facial skin and enhances the elasticity and vitality of the skin by blocking the contact of the skin and air and inhibiting the evaporation of sweat; secondly, a large amount of water in the mask can fully moisten the skin stratum corneum, so that the permeability of the stratum corneum is enhanced, and further nutrient substances in the mask can effectively permeate to promote the metabolism of the skin; and thirdly, the mask has an adhesion function, when the mask is removed, skin dirt (epidermal cell metabolites, excessive sebum, residual makeup and the like) is adhered and removed together with the mask, so that hair follicles of the skin are smooth, and the sebum is smoothly discharged. Therefore, as long as the facial mask is used scientifically and reasonably, the facial mask can effectively improve the water deficiency and dullness of the skin, reduce the generation of fine lines, delay the skin aging, regulate and control the skin oil, and play the roles of brightening and removing acnes to a certain extent.

The invention mainly aims at improving the acne problem of skin, and the parts of the facial skin which are easy to explode are forehead and chin. Acne is a chronic inflammatory lesion of the hair follicles, sebaceous glands associated with sebum metabolism; commonly known as whelk, acne and pimple; is a common disease and a frequently encountered disease of dermatology; it is clinically manifested as white head, blackhead, acne, pimple, pustule, nodule, cyst, depression or hypertrophic scar, and is frequently found in the abundant sebaceous glands of the face, neck, back, etc. of the patient. Acne manifestations fall into several categories: 1) punctate acne: the small spots on the face are scattered at the small white spots and are close to the skin color, and the yellow white and semitransparent fat suppositories which are strip-shaped or large in rice grains can be extruded by hand extrusion; also, small black spots, which appear as small dots, are formed by oxidation. 2) Pimple acne: the most common skin lesions are characterized by small inflamed papules, elevated above the skin, large from rice to pea, dense, somewhat hard, reddish or deep red in color, sometimes with itching or pain as a blackened plug of sebum is visible in the center of the papule or on the tip. 3) Pustular acne: mainly for abscess manifested as skin with mung bean size higher than the skin, white head with pus bag on the top, light red or deep red bottom with pain feeling, viscous pus, and superficial or deep scar after healing. 4) Nodular acne: when the inflamed part is deeper, pustular acne can develop into thick-walled nodules with different sizes, light red or deep red colors, different manifestations, some obvious bulges are formed into hemispheres or cones, and can exist for a long time or be gradually absorbed; if the pus breaks, obvious scar and pigmentation are formed. 5) Atrophic acne: it refers to the acne lesions with papule or pustule, which destroy the sebaceous glands to cause "crater-like" scars, and is often seen in patients who have suffered from the acne lesions for a long time and have had repeated attacks without much attention. 6) Acne conglobata: it is also one of the most serious skin lesions, which have various forms, including acne, pimple, pustule, cyst, nodule and sinus tract, and scar and hard nodule. 7) Cystic acne: sebaceous cyst of different sizes is formed, secondary pyogenic bacterial infection is often caused, bleeding glue-like pus flows out after ulceration, inflammation is not serious, and sinus or scar is gradually formed later. 8) Malignant acne: skin lesions are reddish or purple papules, pustules or nodules ranging from millet grains to broad beans, are soft in texture, contain pus or blood, are not healed for a long time, leave small scars after healing, and can be transformed into gangrene, furuncle and carbuncle, which are often seen in weak constitution.

Researchers analyze that the pathogenesis of acne is complex, and the occurrence and development of acne are mainly considered to be related to factors such as secretion of a large amount of sebum under the action of androgen, change of sebum components, follicular sebaceous gland duct keratosis, propionibacterium acnes colonization, inflammatory reaction, emotional factors, heredity, dietary life habits, environmental factors and immunity.

Acne development is the rapid development of sebaceous glands and excessive secretion of sebum, while the development of sebaceous glands is directly dominated by androgens. After puberty the level of androgens, particularly testosterone, rises rapidly and testosterone is converted in the skin by the action of 5-alpha reductase to dihydrotestosterone which acts in conjunction with the androgen receptor of the sebaceous gland cells. Elevated levels of androgens promote sebaceous gland development and produce large quantities of sebum. In addition, the progesterone and the dehydroepiandrosterone in the adrenal cortex also have a certain effect of promoting sebum secretion. Sebum is mainly composed of squalene, wax esters, triglycerides and small amounts of sterols and cholesterol esters, and acne patients have sebum with higher content of wax esters and lower content of linoleic acid, which can reduce essential fatty acids around hair follicles and promote hyperkeratosis of hair follicle epithelium. Abnormal keratinization of the pilosebaceous canal is another important factor. The formation of comedones begins with the enlargement of the sebaceous gland hair follicle, which is secondary to abnormally keratinized keratinocytes. At the lower part of the follicular infundibulum, lamellar particles in keratinocytes are reduced and replaced by a large number of tension filaments, desmosomes and lipid inclusions, which are not easy to shed, resulting in thickening of the stratum corneum and accumulation of keratinous materials, resulting in blockage of the pilosebaceous canal, obstruction of sebaceous gland discharge, and finally formation of keratotic plugs, i.e., comedones.

Disorders of the secretion and excretion of large amounts of sebum are prone to secondary bacterial infections. A plurality of microorganisms such as propionibacterium acnes, staphylococcus albus and malassezia furfur exist in hair follicles, wherein propionibacterium acnes infection is the most important bacterium, the bacterium is anaerobic bacterium, sebum discharge obstruction just creates a good local anaerobic environment for the propionibacterium acnes, so that the propionibacterium acnes are proliferated in a large quantity, and esterase produced by the propionibacterium acnes can decompose triglyceride in the sebum to produce free fatty acid, and the latter is a main factor causing the formation of acne inflammatory lesions. In addition, Propionibacterium acnes can produce polypeptides, chemotaxis neutrophils, activate complement and make leukocytes release various enzymes, and induce or aggravate inflammation.

The inflammatory process extends throughout the entire process of pathogenesis, from micropowder eruption-closed acne-inflammatory papule-inflammatory erythema (PIE) -post-inflammatory Pigmentation (PIH) -scar. PIE is likely to occur in people with white skin, whereas PIH is likely to occur in patients with darker skin, and infiltration of inflammatory cells can be seen both histopathologically.

Based on the above, the researchers of the invention further provide the acne removing composition of the embodiment aiming at the problem that the skin such as the forehead, the chin and the like is easy to explode. The acne-removing composition can specifically solve the problem of acne removal from three dimensions, namely before, during and after the pox outbreak.

Before the outbreak of the pox, the pox is mainly produced by the vigorous sebum secretion, the hyperplasia of hair follicle epithelium and the hyperkeratosis of hair follicle pores, so that the tube orifice is blocked, and the imbalance of sebum production and discharge is caused. Mature vaccinia is produced when these abnormal keratinocytes accumulate and the lower follicular infundibulum dilates. Therefore, in this dimension, the present invention primarily addresses the problem of controlling oil and regulating keratinous metabolism at the root.

In the vaccinia outbreak, sebum is broken down by bacteria present in the hair follicle (mainly affected by propionibacterium acnes, staphylococcus epidermidis, pityrosporum orbiculare, etc.) to produce free fatty acids which stimulate the hair follicle to cause inflammation, causing damage to the follicle wall to rupture and the entry of the contents of the follicle into the dermis, thus causing an inflammatory response of varying degrees around the hair follicle. Since inflammation promotes the presence of oxygen free radicals, these acids are easily peroxidized and thus more likely to cause acne, which in turn increases the inflammatory attack. Thus, in this dimension, the present invention mainly solves two main problems of bacteriostasis and anti-inflammation.

After an outbreak of pox, various proteases, particularly the inflammatory elastase, slowly break the skin's barrier (they attack the connective tissue matrix, collagen, elastin, etc.) leaving the skin in an unbalanced state of excessive keratinization. Oxygen radicals, also produced in the inflammatory process, not only exacerbate inflammation, but also attack all epidermal cells, thus maximizing the extent of skin disorders. Infection and inflammation can cause massive loss of intracellular sulfhydryl groups, increase tyrosinase activity, increase pigmentation, and promote formation of color spots. Therefore, the present invention mainly solves the problem of barrier repair and prevention of pigmentation generation in this dimension.

The invention provides an acne-removing composition provided by an embodiment, which comprises the following components in parts by weight:

the action mechanism and target point of each component are described in detail below.

1. Spiraea ulmaria extract

The main effective component in the spiraea ulmaria extract is tannin polyphenol, which can reduce sebum secretion by inhibiting the synthesis of a sebum synthesis catalyst-5 alpha-reductase, limit sebum overflow by astringency, prevent acne complications due to the bacteriostatic action, promote skin gloss reduction and make the face more fresh.

2. Almond acid

Mandelic acid, also known as mandelic acid, alpha-hydroxyphenylacetic acid, phenylglycolic acid, and the like. The mandelic acid is one of the fruit acids, has a large molecular weight, is the only fruit acid with fat solubility, has the highest affinity with the skin, and is easy to permeate the stratum corneum and enter the skin to play a role compared with the traditional fruit acid. Therefore, when the mandelic acid penetrates into the skin to act, the mandelic acid can not quickly touch pain receptors to generate pain, mildly soften and reform cutin, effectively improve darkness, pigmentation and scars, and reduce the stimulation and burden of the tartaric acid on the skin.

In the aspect of improving the whole skin, the mandelic acid is quicker and has a longer maintenance effect compared with the glycolic acid, and the mandelic acid is mainly used for regulating cutin metabolism, smoothing pores, tightening skin and improving rough and dark skin. The amygdalic acid is taken as a skin-changing material, so that the trouble of whelk can be effectively solved, especially the symptoms such as inflammatory pustule, papule and the like which are generated along with the skin-changing material are obviously improved after the amygdalic acid is generally used.

3. Lysozyme

Lysozyme, also known as muramidase (muramidase) or N-acetylmuramidase (N-acetylmuramidase glycohydrolase), is an alkaline enzyme that hydrolyzes mucopolysaccharides in pathogenic bacteria. Mainly breaks beta-1, 4 glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in cell wall to decompose insoluble mucopolysaccharide of cell wall into soluble glycopeptide, so as to break cell wall and release content to dissolve bacteria, thereby achieving the bacteriostatic effect.

4. Cannabis leaf extract

The main effective component in the extract of cannabis sativa leaf is cannabidiol CBD, one of the main cannabinoids in cannabis sativa extract. The cannabidiol CBD is a pure natural component extracted from cannabis plant, belongs to a non-addictive active substance, is an extremely effective skin care component, is rich in fatty acid, amino acid, mineral substance and protein, can fill cracks in skin cells, and has the effects of moisturizing and lubricating. In addition, the cannabidiol CBD has the effects of anxiety resistance, pain relief, inflammation resistance, sterilization, oxidation resistance and the like, has strong anti-inflammatory effect, can promote skin hydration, and effectively improves skin problems such as acne, eczema, psoriasis and the like. Therefore, the remarkable pharmacological activity enables the cannabidiol CBD to have great application potential in various fields. The main effects of cannabidiol CBD are: oil control, antiinflammatory, and tranquilizing effects. Cannabidiol can regulate immunity by acting on human endocannabinoid system.

5. Phytosphingosine

Phytosphingosine is based on long chains of sphingomyelin, which can act as a ceramide backbone (in short, the ceramide precursors naturally present in the skin), present in the epidermis and superficial layers of the skin. Acne care based on the lipid barrier function of the skin, the skin's own antibacterial and anti-inflammatory factors. The main functions are represented as follows: 1) reducing skin irritation and inflammation; 2) enhancing skin barrier function; 3) stimulating keratinocyte differentiation; 4) maintaining the skin barrier stable.

6. Clerodendranthus spicatus extract

The raw materials comprise the following effective components: rosmarinic acid and luteolin. The rosmarinic acid has antioxidant, antiinflammatory and antibacterial activities. Luteolin is a polyphenol flavonoid compound in various plants. Luteolin has also been found to inhibit the release of TNF- α from neutrophils and to inhibit matrix metalloproteinases. The material can inhibit melanogenesis by inhibiting endothelin-1 secretion.

In conclusion, the specific six components are selected and controlled in a specific proportion, so that the acne removing problem is solved from three dimensions of oil control before the acne outbreak, keratin metabolism regulation, bacteriostasis and inflammation angle in the acne outbreak, barrier repair after the acne outbreak and pigmentation prevention, and the acne removing composition has a good acne removing effect. The acne-removing composition is particularly suitable for acne-removing care of the skin of the forehead, the chin and the like of the human face.

In some embodiments, the composition comprises the following components in parts by weight:

in some embodiments, the weight ratio of spiraea ulmaria extract, mandelic acid, lysozyme, cannabis leaf extract, phytosphingosine and Clerodendranthus spicatus extract is 1 (0.9-1.1): (1-2) × 10^-3:(0.6～1):(0.15～0.2):(0.6～1)。

an embodiment of the invention also provides application of the acne-removing composition in preparation of skin care products.

An embodiment of the invention also provides a skin care product, which comprises the acne removing composition and a solvent or matrix acceptable in the skin care product.

In some of these embodiments, the skin care product is a facial cleanser, a facial mask, a cream, an eye cream, an essence, a lotion, a toner, an emulsion, or a hydrolat. Cleansing products include face washes, facial cleansers, and the like.

In the traditional facial mask, a piece of complete mask cloth is generally soaked in a mask solution added with a strong-efficacy component, the amount of the mask solution is large, the price of raw materials is very high, and if a sufficient amount of the strong-efficacy component is added to the whole facial mask, the cost of the facial mask is greatly increased. In addition, the strong-effect raw materials of the traditional mask liquid are poor in general stability, and have the problems of instability and the like under the interference of other raw materials in a formula, so that the problems of color change, deformation, component precipitation and the like are caused.

The invention further adopts the brevibacterium saccharolyticum polysaccharide as a main substrate for bearing functional components, and based on the brevibacterium saccharolyticum polysaccharide, the invention provides a brand-new acne-removing nursing membrane. The acne-removing nursing membrane comprises a wafer and an acne-removing composition dispersed in the wafer, wherein the acne-removing composition is any one of the acne-removing compositions; wherein the wafer contains pullulanase.

Particularly, the acne-removing nursing membrane can be suitable for facial nursing needing acne removal, then penetrants such as water, moisturizing water or other facial mask liquids are added, and the strong-effect fine-line removing component carried in the wafer acts on the face under the action of the penetrants, so that the dissolution and absorption of the acne-removing nursing membrane can be effectively promoted, the acne-removing effect is achieved, and the problem of acne is intensively solved.

In some of these embodiments, the wafer includes pectin, carob bean gum, and carrageen. Wherein Chondrus crispus is also called carrageenin or lota Chondrus crispus.

In some of these embodiments, a preservative is also included in the wafer. In some examples, the preservative may be PHL (caprylhydroxamic acid).

Wherein the pectin acts as a skin pH maintaining agent.

Wherein carob bean gum and Chondrus crispus are used as wafer modifier. The wafer made of the single teething brevibacterium amylase polysaccharide is hard and brittle, the toughness of the wafer can be improved by adding the combination of the carob bean gum and the spinach carrageenan, the acne-removing nursing membrane product is prevented from being easily broken in the transportation process, and meanwhile, the acne-removing nursing membrane product is convenient for consumers to use.

Further, the wafer comprises 8-12 parts by weight of pullulanase, 0.5-1.5 parts by weight of preservative, 0.5-1.5 parts by weight of pectin, 0.2-0.5 parts by weight of carob bean gum and 0.5-1 parts by weight of carrageen crispus.

In some embodiments, the acne-removing care patch comprises the following components in parts by weight: 8-12 parts of pullulanase, 0.5-1.5 parts of preservative, 0.5-1.5 parts of pectin, 0.2-0.5 part of carob bean gum, 0.5-1 part of carrageen crispa, 1-5 parts of spiraea ulmaria extract, 1-5 parts of mandelic acid, and lysozyme (2-100) x 10^-3Extract of radix seu folium Cannabis1-5 parts of phytosphingosine, 0.2-1 part of phytosphingosine and 1-3 parts of clerodendranthus spicatus extract.

In one example, the acne-removing care film further contains water, and the acne-removing care film comprises the following raw materials in parts by weight: 8 to 12 percent of pullulanase, 0.5 to 1.5 percent of preservative, 0.5 to 1.5 percent of pectin, 0.2 to 0.5 percent of carob bean gum, 0.5 to 1 percent of crinkle carrageenan, 1 to 5 percent of spiraea ulmaria extract, 1 to 5 percent of mandelic acid, 20 to 1000ppm of lysozyme, 1 to 5 percent of hemp leaf extract, 0.2 to 1 percent of phytosphingosine, 1 to 3 percent of clerodendranthus spicatus extract and 65 to 84 percent of water.

Further, in some embodiments, the acne-removing care film comprises the following components in parts by weight: 10 parts of pullulanase, 1 part of preservative, 1 part of pectin, 0.3 part of carob bean gum, 0.7 part of carrageen crispa, 5 parts of spirea ulmaria extract, 5 parts of mandelic acid, 0.1 part of lysozyme, 5 parts of hemp leaf extract, 1 part of phytosphingosine and 3 parts of clerodendrum spicatum extract.

In one example, the acne-removing care film comprises the following raw materials in parts by weight: 10% of pullulanase, 1% of preservative, 1% of pectin, 0.3% of carob bean gum, 0.7% of crinkle carrageenan, 5% of spirea ulmaria extract, 5% of mandelic acid, 1000ppm of lysozyme, 5% of hemp leaf extract, 1% of phytosphingosine, 3% of clerodendrum spicatum extract and the balance of water.

The embodiment of the invention also provides a preparation method of the acne-removing nursing membrane, which comprises the following steps of S1-S3.

Step S1, providing the acne-removing composition in the acne-removing care film and raw materials required by the wafer.

In some examples, the raw materials required for the wafer also include preservatives, pectin, carob bean gum, and carrageen crispa. Further, in some examples, the wafer desirably includes 8 to 12 parts by weight of pullulanase, 0.5 to 1.5 parts by weight of preservative, 0.5 to 1.5 parts by weight of pectin, 0.2 to 0.5 parts by weight of carob gum, and 0.5 to 1 part by weight of carrageen crispa.

Step S2, mixing and dissolving all components of the raw materials required by the wafer except the preservative with water at 70-80 ℃; cooling to 40-45 ℃, adding the preservative and the raw materials of the acne-removing composition, and mixing to obtain a material body.

In some examples, the mixing and dissolving are performed by stirring, and the stirring speed is 10Hz to 40 Hz. The temperature for mixing and dissolving is preferably 75 ℃. Further, after mixing and dissolving and before cooling, the method also comprises the step of carrying out vacuum heat preservation on the mixed and dissolved materials at 70-80 ℃ for 5-15 min, preferably for 10 min.

And step S3, forming the material body to obtain the acne-removing nursing membrane.

In some examples, the step S3 may be performed by using a mold, and then the material filled in the mold is dried at 35-45 ℃ for 25-35 min, so as to obtain the acne-removing nursing membrane.

The traditional production process of the facial mask is to prepare the components with strong efficacy into essence for use, and in the process, the raw materials need to be dissolved at a higher temperature, so the components with strong efficacy are damaged. The preparation method of the invention, the acne-removing nursing membrane prepared by using medium and low temperature has the following advantages: (1) can protect the functional components in the nursing sheet from being damaged to the maximum extent, preserve the color, taste and efficacy of the sample to the maximum extent, for example, the natural pigment is kept unchanged, and the loss of various aromatic substances can be reduced to the minimum extent. (2) Damage to heat sensitive substances is minimized. (3) The dehydration is thorough, the dry product has light weight and small volume, the occupied area is small during storage, and the transportation is convenient; the various freeze-dried samples were briquetted with significant weight loss. Due to the reduced volume, the packaging costs are correspondingly much lower. (4) More than 95-99% of water can be removed in the drying process, the sample is stable, the product can be stored for a long time without deterioration, and the risk of microbial contamination is avoided. In addition, the preparation process is very simple and convenient, the implementation is convenient, professional freeze-drying equipment is not needed, and the equipment cost is low.

It can be understood that the mould can be arranged according to the shape and size of the acne-removing care membrane prepared as required and the addition amount of the acne-removing care membrane added into the mould can be controlled.

It is understood that the acne-removing care film can also be prepared by directly mixing the raw materials.

The following are specific examples.

Preparation of each nursing membrane sample:

information of each raw material component:

the composition of each patch sample is shown in the following table:

the preparation process for each of the care film samples in the above table is as follows:

the following raw materials were accurately weighed. High-temperature phase: water, pullulanase, pectin, carob gum, lota carrageen. Low-temperature phase: PHL, spiraea ulmaria extract, mandelic acid, lysozyme, cannabis leaf extract, phytosphingosine, and Clerodendranthus spicatus extract.

1) Sequentially adding the high-temperature phase raw materials into the main pot, uniformly dispersing, stirring for 10-40HZ, heating to 75 deg.C for dissolving completely, stirring continuously, and vacuum-holding for 10 min.

2) Cooling to 40-45 deg.C, sequentially adding low temperature phase raw materials, stirring, and stirring for 10-30HZ for 5 min; and (6) discharging.

3) Accurately weighing 10g of the material, pouring the material into a mold, uniformly spreading, placing the mold into a medium-low temperature oven, and setting parameters at 40 ℃ for 30min to obtain the acne-removing nursing wafer.

(II) Performance testing of each of the nursing film samples

1. The test purpose is as follows: the single-center development test (the same laboratory development test) verifies the acne removing efficacy of the product, such as water dispersion loss, melanin, erythema, skin loss rate and the like, by 7 groups of 35 people continuously using the product for 28 days, an instrument test method and front-back comparison.

2. Test sample

2.1 methods of sample use

2.2 study sample requirements

Ensuring that the sample is used under the use conditions specified by the protocol does not pose a foreseeable risk of harm to the health of the subject.

3. Test subject

3.1. Informed consent was issued and all subjects voluntarily enrolled in the test received oral and paper informed consent in accordance with local regulations and regulations. Informed consent explains the nature, purpose and potential risk of participation in the study, and emphasizes the willingness to participate in the test, subjects can be withdrawn from the study at any time for any reason. All subjects can be asked about the study, giving sufficient time to consider before signing. All informed consent signatures must be made prior to study initiation.

3.2. The method includes the steps of selecting a standard, namely Chinese people age 20-55 years (test starting time), insensitivity of subjects to common cosmetics, and no participation in other clinical researches since the subjects are nearly three months

3.3. The skin characterization of the influence test of large-area birthmarks, scratch marks, white spots, pigmented nevi, keloids and the like in a test area of a subject who takes hydroxy acids, whitening and anti-aging medicaments within one month is excluded, wherein a planner who goes out during the test period uses antihistamines for one week or uses immunosuppressants for one month to defend the skin, a study institute for skin in two months uses any anti-inflammatory medicaments, an insulin dependent diabetes patient, a patient with respiratory diseases who is being treated, a patient in lactation or pregnancy, and the like, and a patient with skin diseases or a disease history, and the test area of the subject who takes hydroxy acids, whitening and anti-aging medicaments within one month has the skin characterization.

3.4. The method comprises the following steps of limiting matters, namely treatment for testing influence on a tested part is forbidden during a test period, other skin care products and other products for testing influence are forbidden to be used on the tested part, and daily products such as bath foam, soap, shampoo and the like are forbidden to be replaced during the test period according to the daily products used before the test is started.

3.5. The target number of examples is 35 qualified subjects, and 35 subjects are ensured to be finally completed;

3.6. screening failed, subjects dropped and replaced regular non-enrolled subjects, i.e., subjects signed an informed consent, but failed to enroll because the enrollment/exclusion criteria were not met. Subjects left, i.e., dropped, after randomization or assignment to groups. The failure of the subject to complete the study for any reason was considered to be desquamation, a condition that was no longer supplementary.

Shedding criterion:

subject shedding consent: the subject may be withdrawn at any time for any reason. (according to the declaration of Helsinki),

-adverse/severe adverse events: any investigator believes that continuing the trial is detrimental to the subject,

non-compliance scheme

Subject loss of visit

-other reasons: reasons for withdrawal of other subjects

In other cases, the investigator considered that continued participation in the trial was detrimental to the subject; the CRF form must be filled in until the screen fails or falls off. All subjects who end the trial early must be recorded on the flow sheet by the researcher or research team, the last page "end study", adverse event tables and/or combination therapy tables also apply.

4. Testing instrument

4.1. Skin moisture loss tester Tewameter TM300(Courage & Khazaka, Germany);

4.2. facial image analyzer VISIA-CR (Canfield, usa).

5. Test environment

The environmental requirements are as follows: the temperature is 22.0 ℃ and 1.0 ℃; humidity is 50% and 10%.

6. Test procedure

6.1. Test design 28 days every other day

6.2. Test procedure

Firstly, visiting for the first time, carrying out experimental explanation on a subject, and signing an informed consent.

And secondly, screening the test subjects according to the test requirements, screening 35 subjects into the group, and finally ensuring that 35 subjects are finished.

And thirdly, screening qualified testees, and testing the testees that the skin care products cannot be used in the morning. After the face was cleaned with clean water, rest for 30 minutes in the test environment. After 30 minutes, the face was tested with the instrument. The test subjects were divided into 7 groups of 5 subjects each based on the test results.

Fourthly, after the test is finished, the subject is instructed to use the product, after the subject listens to the instruction, the product is distributed, and the subject uses the test sample every other day for 28 days continuously at home. During this period, subjects followed the instructions of the trial by a visit to the venue after 7, 14 and 28 days after use of the product, followed by a facial test according to step three.

6.3. Test samples used 28 days apart

6.4. Observation/test site face

6.5. Test schedule

Observation item/day of observation	D0	D7	D14	D28
					Visit of the subject	O	O	O	O
Description of the tests and consent	O	-	-	-
					Corneometer-cheek	O	O	O	O
Mexameter-cheek	O	O	O	O
					VISIA-CR-cheek	O	O	O	O

"O" indicates go and "-" indicates not go.

6.6. Observation/test items

The subject devices were tested 4 times before, 7 days, 14 days, 28 days after use.

Skin moisture dispersion: the Tewameter test was used. The water dispersion loss of the skin before use is recorded as T₀And the water dispersion loss on day n is recorded as T_n. Parameter interpretation: lower test values indicate less water dispersion loss from the skin. And (4) judging a result: after the product is used, the water dispersion loss of the test area is obviously reduced, and the test sample has the effect of moisturizing and repairing the skin barrier.

Decrease in skin moisture loss (T)₀-T_n) 100% of/T0, wherein T₀，T_nThe unit is g/hm²。

② erythema on the skin: the mean was taken 3 times using the Mexameter test. Erythema of the skin before use was recorded as Ery0 and erythema on day n as Eryn. Parameter interpretation: lower test values indicate lower levels of erythema in the skin.

And (4) judging a result: after the product is used, the erythema of the tested area is obviously reduced, which shows that the tested sample has the effects of reducing the erythema value of the skin and improving the skin inflammation.

The decrease of skin erythema is (Ery0-Ery n)/Ery 0 is 100%

③ melanin of the skin: the mean was taken 3 times using the Mexameter test. The skin melanin content before use was designated Mel 0 and the melanin content on day n was designated Mel n. Parameter interpretation: lower test values indicate lower levels of melanin in the skin.

And (4) judging a result: after the product is used, the melanin in the tested area is obviously reduced, which shows that the tested sample has the effects of reducing the content of the melanin in the skin and improving the skin pigmentation.

The decrease in skin melanin was (Mel 0-Mel n)/Mel 0 ═ 100%

Fourthly, the skin damage decline rate: 5 specially-assigned persons are designated, VISIA-CR pictures of the samples taken before and after use are compared and observed according to unified standards, and the number of facial skin endothelial lesions of 3 x 6cm in a product area used by the tested persons is recorded. The mean of the number of skin lesions observed by 5 panelists was taken as sample analysis data, and the total number of skin lesions before use was recorded as Sum0, and the total number of skin lesions on the nth day was recorded as Sumn.

Parameter interpretation: the skin lesion is skin damage caused by infection of external pathogenic microorganisms or internal pathological changes, and comprises acne, inflammatory papule and pustule.

And (4) judging a result: the skin damage decline rate is calculated according to the total skin damage before and after the use of the sample,

the skin loss rate is [ (Sum 0-Sum n) ]/Sum 0 is 100%,

and obtaining the evaluation product effectiveness evaluation according to the skin damage treatment decline rate: the effect is shown: the skin damage decline rate is more than 60 percent, and the effect is as follows: the skin damage decline rate is less than 60 percent after 20 percent and is ineffective: the skin damage decline rate is less than 20 percent. Total effective rate (number of effective cases + number of effective cases)/total number of cases × 100%.

7. Test results

7.1 reduction in the amount of water lost to the skin, as shown in the following table and in FIG. 1:

in FIG. 1, reference samples-1 to-4 were designated as D1 to D4, respectively, and examples-1 to-3 were designated as A1 to A3, respectively. FIGS. 2-4 are similar.

As can be seen from the data in the table and the accompanying fig. 1, the water dispersion of the skin is further reduced with the addition of the functional components in each dimension, which indicates that the barrier function of the skin is gradually improved. In example-2, the reduction in water dispersion of the skin increased by 10.01% for 14 days and reached 13.41% for 28 days; in example-3, the reduction in water dispersion of the skin increased by 11.01% for 14 days and reached 14.57% at 28 days. It is shown that the barrier function of the skin is gradually improved, and the moisturizing effect of the skin is gradually improved.

7.2 reduction of skin erythema as shown in the following Table and attached FIG. 2:

from the result of the reduction of skin erythema, the skin erythema reduction is obviously improved along with the superposition of the functional components in all dimensions, particularly the superposition of the anti-inflammatory functional components, which indicates that the skin inflammation is gradually reduced, in example-2, the reduction of the skin erythema is 18.34% in 14 days, and reaches 22.97% in 28 days, which indicates that the skin inflammation is reduced, and the skin redness problem is gradually improved.

7.3 reduction of melanin in the skin

From the result of the reduction of the skin melanin, the use of the raw materials with the keratolytic effect obviously reduces the skin melanin content along with the superposition of the functional components with various dimensions, when the skin has inflammation, the inflammatory factors induce the melanocyte to activate to generate melanin, the use of the anti-inflammatory components reduces the melanin synthesis, and the content of the skin after the superposition obviously reduces, which indicates that the inflammation of the skin gradually subsides, in example-2, the reduction of the melanin of the skin in 14 days is 17.94%, and reaches 24.99% in 28 days; in example-3, the melanin reduction in the skin was 18.93% at 14 days and reached 27.82% at 28 days. Shows that the inflammation of the skin is reduced, and prevents the problems of local pox marks and the like caused by the inflammation.

7.4 skin lesion declination rate

As a result of the rate of decrease in skin lesions, it was found that the decrease in the number of pox was significantly increased with the addition of the effective ingredient. Example-2 the skin damage reduction rate of the skin is improved to 66.63% at 14 days and 88.42% at 28 days by the combination of the additive raw materials and the multi-dimensional combined action aiming at the problems of the three stages before, during and after the pox outbreak. Example-3 the skin loss reduction rate of the skin was increased to 72.29% at 28 days and to 94.44% at 28 days on the forehead.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. The acne-removing composition is characterized by comprising the following components in parts by weight:

2. the acne-removing composition according to claim 1, which comprises the following components in parts by weight:

3. the acne-removing composition according to claim 1, wherein the weight ratio of the spiraea ulmaria extract, the mandelic acid, the lysozyme, the cannabis sativa leaf extract, the phytosphingosine and the clerodendranthus spicatus extract is 1 (0.9-1.1): (1-2) x 10^-3:(0.6～1):(0.15～0.2):(0.6～1)。

4. The acne-removing composition according to claim 1, which comprises the following components in parts by weight:

5. use of the acne-removing composition according to any one of claims 1 to 4 in the preparation of a skin care product.

6. A skin care product comprising the acne treatment composition according to any one of claims 1 to 4 and a solvent or matrix acceptable in the skin care product.

7. An acne-removing care film, which is characterized by comprising a wafer and an acne-removing composition dispersed in the wafer, wherein the acne-removing composition is the acne-removing composition according to any one of claims 1 to 4; wherein the wafer contains pullulanase.

8. The acne treatment sheet of claim 7 wherein said wafer further comprises pectin, carob bean gum, and carrageen crispa.

9. The acne treatment sheet of claim 8, further comprising a preservative in the wafer, wherein the preservative is PHL.

10. The acne treatment care patch according to claim 9, wherein the acne treatment care patch comprises the following components in parts by weight:

11. the preparation method of the acne-removing nursing membrane is characterized by comprising the following steps:

providing an acne removing composition in an acne removing nursing membrane sheet according to any one of claims 7 to 10 and raw materials required by a wafer;

and (4) forming the material body to obtain the acne-removing nursing membrane.

12. The preparation method of the acne-removing nursing membrane is characterized by comprising the following steps:

providing an acne removing composition in an acne removing nursing membrane of any one of claims 9 to 10 and raw materials required by a wafer;

and (4) forming the material body to obtain the acne-removing nursing membrane.

13. The preparation method of the acne-removing nursing membrane sheet according to claim 12, characterized in that the raw materials comprise, by weight: 8 to 12 percent of pullulanase, 0.5 to 1.5 percent of preservative, 0.5 to 1.5 percent of pectin, 0.2 to 0.5 percent of carob bean gum, 0.5 to 1 percent of crinkle carrageenan, 1 to 5 percent of spiraea ulmaria extract, 1 to 5 percent of mandelic acid, 20 to 1000ppm of lysozyme, 1 to 5 percent of hemp leaf extract, 0.2 to 1 percent of phytosphingosine, 1 to 3 percent of clerodendranthus spicatus extract and 65 to 84 percent of water.