CN112438905B - Moisturizing and skin-brightening composition and application thereof - Google Patents

Moisturizing and skin-brightening composition and application thereof Download PDF

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CN112438905B
CN112438905B CN202011405636.6A CN202011405636A CN112438905B CN 112438905 B CN112438905 B CN 112438905B CN 202011405636 A CN202011405636 A CN 202011405636A CN 112438905 B CN112438905 B CN 112438905B
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skin
composition
extract
amino acid
water
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CN112438905A (en
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黄伟雄
张文闻
刘志伟
张小敏
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Osimy Daily Chemical Industry (guangzhou)co Ltd
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Osimy Daily Chemical Industry (guangzhou)co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/732Starch; Amylose; Amylopectin; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions

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  • Cosmetics (AREA)

Abstract

The invention relates to the technical field of cosmetics, in particular to a water replenishing and skin brightening composition and application thereof. A moisturizing and skin lightening composition comprises a moisturizing agent and a skin conditioning agent; the humectant at least comprises 0.01-0.05% of low sodium hyaluronate with the molecular weight of 5-40 ten thousand and 0.01-0.05% of conventional sodium hyaluronate with the molecular weight of 120-150 ten thousand, wherein the total mass of the composition is taken as a reference. The sodium hyaluronate with different molecular weights adopted in the components has the effects of deeply replenishing water and locking water; the skin conditioner from plants is matched to promote the moisture of the skin and lock the moisture at the same time, so that the skin is prevented from being dry, fine lines are smoothed, and the skin luster is improved; the whitening and skin-brightening facial mask has the effects of whitening and brightening skin, is reasonable in raw material compounding and synergistic, and plays the effects of moisturizing and brightening skin of each effective raw material to the greatest extent.

Description

Moisturizing and skin-brightening composition and application thereof
Technical Field
The invention relates to the technical field of cosmetics, in particular to a water replenishing and skin brightening composition and application thereof.
Background
The skin of people is various and has mixed type, sensitive type, oily type, dry type and the like, along with the improvement of modern living standard, people pay more and more attention to external images, increase confidence under various activities and occasions with beautiful images, simultaneously, more pursue skin health under beautiful appearance, and show the pursuit of people for high-end life with healthy skin and beautiful images, so the whitening products are always magical to people.
The mask, as one category of skin care products, is the most common and portable skin care product in the current market, and is popular with consumers. The most basic and important purpose is to make up the cleaning work of makeup removal and face washing which are still insufficient, and the maintenance functions of the facial mask are realized by matching with other essence components on the basis, such as water replenishing and moisturizing, whitening and skin brightening, firming and anti-aging, grease balancing and the like. The skin care mechanism of the facial mask is that the facial mask temporarily isolates outside air and pollution within a short time when covering the face, the skin temperature is increased, pores are expanded, the oxygen content of the skin is increased, the skin is favorable for removing products of metabolism of epidermal cells, water in the facial mask permeates into the horny layer of the epidermis, the skin becomes soft, and the skin is naturally bright and elastic.
Disclosure of Invention
Unless otherwise indicated, implied from the context, or customary in the art, all parts and percentages herein are by weight and the testing and characterization methods used are synchronized with the filing date of the present application. To the extent that a definition of a particular term disclosed in the prior art is inconsistent with any definitions provided herein, the definition of the term provided herein controls.
The words "preferred", "preferably", "more preferred", and the like, in the present invention, refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention. The sources of components not mentioned in the present invention are all commercially available.
After earnest study to solve the above problems, the inventors of the present invention have found that a composition has an excellent effect of moisturizing and skin-lightening by using a humectant and a plant-derived skin conditioner in combination in a specific ratio as active ingredients, and that the composition is safe and mild, contains a soothing substance that is bactericidal and anti-allergic, and is suitable for various people.
In a first aspect, the present invention provides a moisturizing and skin lightening composition comprising a moisturizing agent and a skin conditioning agent; the humectant at least comprises 0.01-0.05% of low sodium hyaluronate with the molecular weight of 5-40 ten thousand and 0.01-0.05% of conventional sodium hyaluronate with the molecular weight of 120-150 ten thousand, wherein the total mass of the composition is taken as a reference.
Moisture-retaining agent
The humectant refers to a component having a property of easily retaining water so as to have a property of increasing the water content of the horny layer over a long period of time.
Preferably, the humectant at least comprises 0.01-0.05% of low sodium hyaluronate with the molecular weight of 5-40 ten thousand and 0.01-0.05% of conventional sodium hyaluronate with the molecular weight of 120-150 ten thousand.
Sodium hyaluronate has different molecular weights, each acting on different structures of the skin. Hyaluronic acid with large molecular weight acts on the sebaceous membrane of the skin surface. Hyaluronic acid with medium molecular weight acts on epidermal layer of skin, and hyaluronic acid with small molecular weight acts on dermal layer of skin. The preferred 5-40 ten thousand low sodium hyaluronate and 120-150 ten thousand conventional sodium hyaluronate cooperate with each other to quickly absorb water and then store the water in the dermis layer, so that a protective film is formed on the epidermis layer of the skin, the purposes of moisturizing and locking the water of the skin are fundamentally solved, and the elastic and smooth skin is repaired and recovered.
In addition, in order to further obtain a better use feeling, the humectant further comprises 1 to 5% of an amino acid derivative, more preferably 1 to 3% of an amino acid derivative in addition to the preferable sodium hyaluronate.
The amino acid derivative is preferably a nitrogen-substituted amphoteric amino acid, and may be derived from natural sources, for example, lycium barbarum and kelp, or may be a chemically synthesized amino acid derivative, and may be used per se. Among these nitrogen-substituted amphoteric amino acids, an amphoteric amino acid in which the nitrogen atom of the amino acid is substituted with at least one R is more preferable; wherein R is any one of alkyl, carbonyl, cycloalkyl, heteroalkyl or aryl.
More preferably, R is any of an alkyl group, an alkoxycarbonyl group, an aralkyloxycarbonyl group, an aryloxycarbonyl group, an alkenyloxycarbonyl group, or an acyl group.
Among them, the alkyl group in the above-mentioned alkyl group and alkoxy group or alkyloxy group, alkoxycarbonyl group or alkylcarbonyl group may be a straight-chain or branched alkyl group, and may be selected from methyl group, ethyl group, propyl group, isopropyl group, n-butyl group, sec-butyl group, isobutyl group, tert-butyl group, n-pentyl group, octyl group, dodecyl group, octadecyl group and the like.
The aralkyl group is preferably a phenyl-C1-4 alkylene group, wherein the C1-4 alkylene group is exemplified by methylene, ethylene, propylene, 2-methylpropylene, and butylene. The alkenyl group in the alkenyloxycarbonyl group is not limited, but preferred is an alkenyl group having 3-9 carbon atoms, and examples thereof include 1-butene and 2-butene.
The benzene ring contained in the above-mentioned aralkyloxycarbonyl group, aryloxycarbonylaryl group and benzoyl group may have at most 3 substituents which may be the same or different, and the substituents are not limited to these, and examples thereof include a halogen atom (fluorine, chlorine, bromine and iodine), a hydroxyl group, a mercapto group, a methyl group, a trifluoromethyl group, an amino group and a nitro group.
Through further research on amino acid derivatives, amino acid derivatives suitable for the present invention include, specifically, alkoxycarbonyl-substituted amino acid derivatives such as N- (t-butoxycarbonyl) alanine, N- (t-butoxycarbonyl) proline, N- (t-butoxycarbonyl) leucine, N- (t-butoxycarbonyl) isoleucine, N- (t-butoxycarbonyl) valine, N- (t-butoxycarbonyl) tryptophan, N- (t-butoxycarbonyl) phenylalanine, N- (t-butoxycarbonyl) serine, N- (t-butoxycarbonyl) methionine, N- (t-butoxycarbonyl) glutamine, N- (t-butoxycarbonyl) glutamic acid, N- (t-butoxycarbonyl) lysine, N- (t-butoxycarbonyl) tyrosine, and the like; aralkyloxycarbonyl-substituted amino acid derivatives such as N-benzyloxycarbonyl alanine, N-benzyloxycarbonyl proline, N-benzyloxycarbonyl leucine, N-benzyloxycarbonyl isoleucine, N-benzyloxycarbonyl valine, N-benzyloxycarbonyl tryptophan, N-benzyloxycarbonyl phenylalanine, N-benzyloxycarbonyl serine, N-benzyloxycarbonyl methionine, N-benzyloxycarbonyl glutamine, N-benzyloxycarbonyl glutamic acid, and N-benzyloxycarbonyl lysine; an aryloxycarbonyl-substituted amino acid derivative such as N-phenoxycarbonylalanine, N-phenoxycarbonylproline, N-phenoxycarbonylleucine, N-phenoxycarbonylisoleucine, N-phenoxycarbonylvaline, N-phenoxycarbonyltryptophan, N-phenoxycarbonylphenylalanine, N-phenoxycarbonylserine, N-phenoxycarbonylmethionine, N-phenoxycarbonylglutamine, N-phenoxycarbonylglutamic acid, or N-phenoxycarbonyllysine; and acyl-substituted amino acid derivatives such as N-benzoylalanine, N-benzoylproline, N-benzoylleucine, N-benzoylisoleucine, N-benzoylvaline, N-benzoyltryptophan, N-benzoylphenylalanine, N-benzoylserine, N-benzoylmethionine, N-benzoylglutamine, N-benzoylglutamic acid, and N-benzoyllysine. Among them, the most suitable amino acid derivative is preferably natural anhydrous trimethylglycine NMF-50, which is naturally present in Lycium barbarum and Laminaria japonica, and has high absorbability and high activity.
Anhydrous trimethylglycine NMF-50 is mild and mild, does not irritate the skin, and can improve the use feeling and stability after alcohols are added, particularly butanediol and beta-glucan of Schizophyllum commune, wherein anhydrous trimethylglycine is zwitter ion and has hydrogen bond interaction with butanediol and beta-glucan of Schizophyllum commune, in addition, hydrophilic groups and compact arrangement are caused under the attraction of positive and negative ion pairs, the stability of the composition can be improved through the synergy of the three, in addition, a film is formed together with the conventional sodium hyaluronate to retain water on the surface of the skin, and the active conditioner ingredient permeates into dermis to improve the skin condition.
More preferably, the moisturizer contains 0.5-5% of alcohol in addition to the sodium hyaluronate and the amino acid derivative, and the alcohol can be widely used in cosmetics because the alcohol contains a polar group which can significantly increase the water content on the skin surface.
By way of study, it is preferred that the humectants more suitable for the present invention comprise, based on the total mass of the composition:
0.01-0.05% of low sodium hyaluronate with molecular weight of 5-40 ten thousand and 0.01-0.05% of low sodium hyaluronate with molecular weight of 0.01-0.05%
120-150 ten thousand of conventional sodium hyaluronate, 1-5% of amino acid derivatives and 0.5-5% of alcohols.
As the alcohol of the humectant, the present invention preferably includes water-soluble diols and alcohols of water-soluble trihydric or higher polyhydric alcohols. Among them, the water-soluble diol is not particularly limited as long as it is a water-soluble alcohol having two hydroxyl groups. Representative examples thereof are 1, 2-pentanediol, hexanediol, 1, 3-butanediol, propylene glycol and the like, and these alcohols may be used alone or in admixture; among these water-soluble diols, 1, 3-butanediol is preferably used. Representative examples of the water-soluble trihydric or higher polyhydric alcohol include glycerol diglycerol, triglycerol, polyglycerol, neopentyl glycerol, sorbitol, erythritol, pentaerythritol, glucose, galactose, fructose, sucrose, maltose, xylose, xylobiose, oligosaccharide and other saccharides, and these trihydric or higher polyhydric alcohols may be used alone or in combination, and among them, water-soluble Glucan, Glucan modified with a hydrophilic group, and hydrophilic Glucan extracted from natural organisms are preferable, and among them, β -Glucan derived from schizophyllum, specifically SC-Glucan, which is both water-soluble and electrically neutral, is most preferable. 1, 3-butanediol and SC-Glucan are particularly preferable alcohols which can be used as a humectant in the present invention, and either one of them may be added when used as an alcohol, or both may be used in combination, more preferably both are used in combination, and when both are mixed, the mass ratio of 1, 3-butanediol and SC-Glucan may be present in a wide range, and 1, 3-butanediol and SC-Glucan are preferably compounded in accordance with (1 to 3) to (1 to 3).
beta-Glucan of Schizophyllum commune, especially SC-Glucan, is preferred as the present invention because SC-Glucan is from Schizophyllum commune, is very hydrophilic compared with conventional Glucan, has an appropriate molecular weight of 60-120 ten thousand, and thus can more rapidly permeate into the epidermal layer, keep the skin healthy and elastic, and in addition, its own electrical neutral property acts with protein or vitamin in the extract, especially yeast extract, not only can stabilize various protein molecules, but also because it contains more branched structures, hydroxyl groups extending outside easily act with moisturizers, so that various fat-soluble substances in the extract can enter the interior of the extract, and finally, the active substances can be rapidly absorbed in the coating process.
Skin conditioning agent
The skin conditioner is an active ingredient which acts on the skin in cosmetics, and the mass ratio of the humectant to the skin conditioner is preferably (3-10): 1-3), more preferably (5-8): 1-3.
In the present invention, the skin conditioner is preferably an active substance having a skin-lightening action, and may be derived from natural products or chemically synthesized substances, and is preferably a skin conditioner derived from natural products in view of safety and environmental protection. Among these skin conditioners of natural origin, plant actives are the first choice.
Suitable botanical active ingredients include, for example, but are not limited to, hedera helix leaf/stem extract, magnolia sharkstrails bark extract, polygonum cuspidatum root extract, helichrysum arenarium extract, laminaria cuneata extract, secale seed extract, tropaeolum majus extract, orthosiphon aristatus extract, ganoderma atrum extract, purslane extract, leontopodium alpinum extract, cryphonium chrysosporium extract, glycyrrhiza glabra root extract, lotus seed extract, hydrolyzed rice extract, snow lotus flower extract, yeast extract, cactus extract, cotton rose extract, olive leaf extract, scutellaria baicalensis extract, tapioca starch, and the like.
Through studies on the above plant active substances, the skin conditioner most suitable for the present invention preferably includes yeast extract, cactus extract, hibiscus mutabilis extract, olive leaf extract, scutellaria extract, tapioca starch, and these ingredients may be used alone or in combination.
The yeast extract is rich in various nutritional components such as vitamins, amino acids, polysaccharides, trace elements, etc., and has effects of resisting aging, locking water, keeping moisture, and brightening skin.
The radix et caulis Opuntiae Dillenii extract has antibacterial effect, and is effective in promoting skin growth factor generation, and caring skin and resisting aging.
The hibiscus mutabilis extract is a pure natural product extracted from hibiscus petals, has the effects of inhibiting bacteria and diminishing inflammation, contains various functional components such as flavonoid glycoside and anthocyanin, and can be used as a skin conditioner for cooling blood, stopping bleeding, removing heat and toxic materials.
The folium Canarii albi extract contains several phenols, and also contains VC and resinol, etc., and has effects of scavenging free radicals, promoting collagen synthesis, resisting oxidation, preventing wrinkle, and delaying aging.
The Scutellariae radix extract can absorb ultraviolet rays, has antiallergic effect, and can repair sunburned skin, inhibit melanin generation, and make skin clean and smooth.
The tapioca starch can be used as emollient, and in addition, the tapioca starch has special fragrance and can play a role in thickening and emulsifying when being used as cosmetics.
More preferably, skin conditioning agents suitable for use in the present invention include yeast extract, Irrbate stimulus suppression factor, LS-07813 patent plant extract.
Irribate stimulus inhibition factor INCI is named as water, glycerol, trehalose, Opuntia Streptacantha stem extract, tapioca starch; LS-07813 patent plant extractive solution mainly contains flos Hibisci Mutabilis extractive solution, folium Canarii albi extractive solution and Scutellariae radix extractive solution.
Irribate irritation inhibiting factor is used as one of skin conditioners, the biggest function of the Irribate irritation inhibiting factor is to maintain the water-oil balance of skin and establish a healthy skin barrier, the Irribate irritation inhibiting factor is used as a patent formula and can be cooperated with other conditioners disclosed by the invention, cassava starch swells in water to play a thickening role, and then hydrophilic substances on the starch easily wrap the moisturizing agent disclosed by the invention, and the substances are separated from micelles to permeate into the skin during use and are absorbed more easily. The LS-07813 patent plant extract contains multiple plant extracts containing fat-soluble and water-soluble substances, so that the weight ratio of yeast extract, Irribate stimulation inhibition factor and LS-07813 patent plant extract in the skin conditioner is required to be within the range for reducing the greasy feeling, and the weight ratio of yeast extract, Irribate stimulation inhibition factor and LS-07813 patent plant extract is preferably (0.1-1): 0.01-1), more preferably (0.1-1): 0.1-0.5).
The composition of the present invention may further contain additives generally used in the art within a range not to impair the desired effects of the present invention. These additives may impart various forms to the composition for use, for example, the composition may be in the form of a solution, emulsion, viscous mixture, or the like.
Examples of the additives include: emulsifiers, preservatives, and the like.
Examples of the emulsifier include, but are not limited to, one or more compounds selected from the group consisting of polysorbate, glycoside, polyoxyethylene fatty acid ester, fatty acid amide, polyethylene glycol ester, glyceride, and glyceride compounds having HLB of 10 to 16, and specifically, polyethylene glycol-7 glyceryl cocoate, polyethylene glycol-20 amygdalin, polyethylene glycol-60 amygdalin, polyethylene glycol-25 hydrogenated castor oil, polyethylene glycol-60 hydrogenated castor oil stearamide, polyethylene glycol-100 stearate, polysorbate 85, polysorbate 80, polysorbate 60, polyethylene glycol-7 olive oleate, cetearyl glucoside, polyethylene glycol-8 oleate, oleyl ether-10, oleyl ether-20, cetyl ether-10, and glyceryl ether-10, At least one of ceteth-20, polyethylene glycol-8 laurate, cocamide, isosteareth-20, ceteth-20, steareth-20 and 21, hydroxyethyl cellulose, and the like. Among these emulsifiers, hydroxyethyl cellulose is more preferable, and in general, when the above-mentioned emulsifier is used, the emulsifier is preferably used in an amount of 1 to 20 wt%, more preferably 3 to 10 wt%, based on the total weight of the composition.
Examples of the preservative include, but are not limited to, methyl paraben, ethyl paraben, butyl paraben, menthone, 1, 3-butanediol, 1, 2-pentanediol, hexanediol, and leupeptin antibacterial solution. In general, when the above-mentioned preservative is used, the preservative is preferably used in an amount of 0.1 to 5 wt%, more preferably 0.5 to 2 wt%, based on the total weight of the composition.
In a second aspect, the present invention provides a method for preparing the above-mentioned moisturizing and skin-brightening composition, comprising the following steps:
(1) adding deionized water into a clean vacuum emulsifying pot, heating to 70 ℃, uniformly mixing low-sodium hyaluronate, conventional sodium hyaluronate and 1, 3-butanediol, adding into a production tank, homogenizing until completely dissolved, and uniformly stirring;
(2) mixing deionized water and hydroxyethyl cellulose, stirring, dispersing, adding into a production cylinder (which can not be prepared in advance, adding into production immediately after mixing, stirring and dispersing, starting homogenizing during adding), continuously adding to 82-85 deg.C, keeping the temperature, defoaming for 30 min, and cooling with cooling water;
(3) when the temperature is 45 ℃, adding anhydrous trimethylglycine NMF-50, beta-Glucan SC-Glucan, yeast extract, Irribate stimulus inhibition factor and LS-07813 patent plant extract in sequence, adding the next after adding one material, stirring uniformly, and adding the mixture;
(4) adding antiseptic, stirring, slowly adding into production pot, and stirring. Sampling and detecting, and filtering and discharging the qualified product by using a 400-mesh filter screen.
In a second aspect, the present invention provides the use of a composition as described above in a facial mask fluid. For example, the composition can be directly applied to a facial mask as a mask solution to obtain the facial mask with moisturizing and skin brightening effects.
Has the advantages that: the sodium hyaluronate with different molecular weights adopted in the components has the effects of deeply replenishing water and locking water; the skin conditioner from plants is matched to promote the moisture of the skin and lock the moisture at the same time, so that the skin is prevented from being dry, fine lines are smoothed, and the skin luster is improved; the whitening and skin-brightening facial mask has the effects of whitening and brightening skin, is reasonable in raw material compounding and synergistic, and plays the effects of moisturizing and brightening skin of each effective raw material to the greatest extent.
Detailed Description
The present invention is described in detail below with reference to examples, which are provided for the purpose of further illustration only and are not to be construed as limiting the scope of the present invention, and the insubstantial modifications and adaptations thereof by those skilled in the art based on the teachings of the present invention will still fall within the scope of the present invention.
Example 1
The moisturizing and skin-brightening composition (A1) comprises the following components in percentage by weight:
Figure BDA0002814033350000071
Figure BDA0002814033350000081
example 2
The moisturizing and skin-brightening composition (A2) comprises the following components in percentage by weight:
name of raw materials The dosage is%
Low molecular sodium hyaluronate 0.03
Conventional sodium hyaluronate 0.02
Anhydrous trimethylglycine NMF-50 2.3
1, 3-butanediol 4.5
Yeast extract 0.7
Irribate stimulus inhibitory factor 0.5
LS-07813 patent plant extract 0.3
Hydroxyethyl cellulose 0.03
Xinxian Ketone 0.3
1,2 pentanediol 2.2
Bright peptide antibacterial liquid 1.4
Deionized water To 100
Example 3
The moisturizing and skin-brightening composition (A3) comprises the following components in percentage by weight:
Figure BDA0002814033350000082
Figure BDA0002814033350000091
example 4
The moisturizing and skin-brightening composition (A4) comprises the following components in percentage by weight:
name of raw materials The dosage is%
Low molecular sodium hyaluronate 0.03
Conventional sodium hyaluronate 0.02
Anhydrous trimethylglycine NMF-50 2.3
beta-Glucan SC-Glucan 2.5
1, 3-butanediol 2.0
Yeast extract 0.7
LS-07813 patent plant extract 0.8
Hydroxyethyl cellulose 0.03
Xinxian Ketone 0.3
1,2 pentanediol 2.2
Bright peptide antibacterial liquid 1.4
Deionized water To 100
Example 5
The moisturizing and skin-brightening composition (A5) comprises the following components in percentage by weight:
Figure BDA0002814033350000092
Figure BDA0002814033350000101
example 6
The moisturizing and skin-brightening composition (A6) comprises the following components in percentage by weight:
name of raw materials The dosage is%
Low molecular sodium hyaluronate 0.03
Conventional sodium hyaluronate 0.02
Anhydrous trimethylglycine NMF-50 2.3
Oat-beta-glucan 2.5
1, 3-butanediol 2.0
Yeast extract 0.7
Irribate stimulus inhibitory factor 0.5
LS-07813 patent plant extract 0.3
Hydroxyethyl cellulose 0.03
Xinxian Ketone 0.3
1,2 pentanediol 2.2
Bright peptide antibacterial liquid 1.4
Deionized water To 100
Example 7
The moisturizing and skin-brightening composition (A7) comprises the following components in percentage by weight:
name of raw materials The dosage is%
Low molecular sodium hyaluronate 0.03
Conventional sodium hyaluronate 0.02
1, 3-butanediol 2.0
Yeast extract 0.7
Irribate stimulus inhibitory factor 0.5
LS-07813 patent plant extract 0.3
Hydroxyethyl cellulose 0.03
Xinxian Ketone 0.3
1,2 pentanediol 2.2
Bright peptide antibacterial liquid 1.4
Deionized water To 100
Evaluation of Performance
1. Evaluation of stability:
the test method comprises the following steps: the composition was left at constant temperatures of 0 degrees, 25 degrees and 45 degrees for 3 weeks, and whether or not the appearance was changed was observed and evaluated according to the following criteria: a indicates no separation and aggregation, B indicates a little separation and aggregation, and C indicates separation and aggregation. The results are shown in Table 1 below.
TABLE 1 stability evaluation results
Examples 0 degree 25 degree 45 degree
Example 1 A A A
Example 2 A A B
Example 3 A A B
Example 4 A A A
Example 5 B A A
Example 6 A A A
Example 7 B A B
2. Using immediate perception evaluation:
the test method comprises the following steps: please refer to thirty subjects aged 22 to 40 years old who used the compositions of the examples, and the mean age of the subjects was 31.83 years old with a standard deviation of 5.00. The results of the immediate efficacy evaluation of the test products by the subjects were performed according to a random schedule (score 1 indicates a very poor compliance with the described test product usage experience efficacy; score 7 indicates a very good compliance with the described test product usage experience efficacy; score 5 indicates a somewhat good compliance with the described test product usage experience success efficacy, a higher score indicates a better product effect on improving the skin condition or indicates a more satisfactory product efficacy); according to the scoring criteria, 30 subjects evaluated the efficacy of the test product after using it in 4 aspects including no greasy feeling, no dry feeling, absorbency at the time of application, and effect as a makeup base. The result evaluation is graded by the number ratio of more than 5, and A is the ratio of more than 60%; b accounts for 60-50%; c is contained in an amount of less than 50%, and the results are shown in Table 2 below.
Table 2 efficacy evaluation results
Examples Has no greasy feeling No feeling of dryness Absorbency of Cosmetic priming effect
Example 1 A A A A
Example 2 A B B A
Example 3 A B B B
Example 4 B A B B
Example 5 C A B A
Example 6 A A B A
Example 7 A C B C

Claims (5)

1. A moisturizing and skin lightening composition is characterized by comprising a humectant and a skin conditioner; the humectant at least comprises 0.01-0.05% of low sodium hyaluronate with the molecular weight of 5-40 ten thousand and 0.01-0.05% of conventional sodium hyaluronate with the molecular weight of 120-150 ten thousand, wherein the total mass of the composition is taken as a reference;
the humectant also comprises 1-5% of amino acid derivatives by taking the total mass of the composition as a reference;
the amino acid derivative is nitrogen-substituted amphoteric amino acid;
the nitrogen-substituted amphoteric amino acid is an amphoteric amino acid in which the nitrogen atom of the amino acid is substituted by at least one alkyl, carbonyl, cycloalkyl, heteroalkyl or aryl group;
the amino acid derivative is natural anhydrous trimethylglycine NMF-50;
the humectant also comprises 0.5-5% of alcohol based on the total mass of the composition;
the alcohols comprise water-soluble dihydric alcohol and water-soluble polyhydric alcohol above ternary;
the water-soluble dihydric alcohol is 1, 3-butanediol; the water-soluble trihydric alcohol is beta-Glucan SC-Glucan, and the mass ratio of 1, 3-butanediol to SC-Glucan is (1-3) to (1-3).
2. The composition of claim 1, wherein the humectant and the skin conditioning agent are present in a mass ratio of (3-10) to (1-3).
3. The composition of claim 2, wherein the skin conditioning agent comprises at least two of yeast extract, cactus extract, hibiscus manihot extract, olive leaf extract, scutellaria baicalensis extract, and tapioca starch.
4. The composition of any one of claims 1 to 3, wherein the composition is in the form of a viscous mixture.
5. Use of a composition according to any of claims 1-4 in a facial mask fluid.
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CN115804745A (en) * 2022-12-27 2023-03-17 广州天然国度生物科技有限公司 Skin care and soothing repair composition and application thereof

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