CN112891250A - High-elasticity moisturizing and anti-aging skin cream and preparation method thereof - Google Patents
High-elasticity moisturizing and anti-aging skin cream and preparation method thereof Download PDFInfo
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- CN112891250A CN112891250A CN202110102937.XA CN202110102937A CN112891250A CN 112891250 A CN112891250 A CN 112891250A CN 202110102937 A CN202110102937 A CN 202110102937A CN 112891250 A CN112891250 A CN 112891250A
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- skin cream
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- 239000002884 skin cream Substances 0.000 title claims abstract description 58
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 25
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 50
- 239000008367 deionised water Substances 0.000 claims abstract description 47
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 47
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 44
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000003906 humectant Substances 0.000 claims abstract description 33
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 27
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 27
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 27
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 26
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims abstract description 26
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- JSOVGYMVTPPEND-UHFFFAOYSA-N 16-methylheptadecyl 2,2-dimethylpropanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)C(C)(C)C JSOVGYMVTPPEND-UHFFFAOYSA-N 0.000 claims abstract description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 13
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 13
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 13
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960001631 carbomer Drugs 0.000 claims abstract description 13
- 229960000541 cetyl alcohol Drugs 0.000 claims abstract description 13
- -1 dimethyl siloxane Chemical class 0.000 claims abstract description 13
- 239000004200 microcrystalline wax Substances 0.000 claims abstract description 13
- 235000019808 microcrystalline wax Nutrition 0.000 claims abstract description 13
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000004006 olive oil Substances 0.000 claims abstract description 13
- 235000008390 olive oil Nutrition 0.000 claims abstract description 13
- 229940032094 squalane Drugs 0.000 claims abstract description 13
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 13
- 239000011718 vitamin C Substances 0.000 claims abstract description 13
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 10
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 10
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000008117 stearic acid Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 238000006243 chemical reaction Methods 0.000 claims description 99
- 238000003756 stirring Methods 0.000 claims description 85
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 42
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 32
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 30
- QWVGKYWNOKOFNN-UHFFFAOYSA-N o-cresol Chemical compound CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 27
- 238000010992 reflux Methods 0.000 claims description 25
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 20
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 18
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 15
- 239000012286 potassium permanganate Substances 0.000 claims description 15
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 14
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 14
- 238000001816 cooling Methods 0.000 claims description 14
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 229920001661 Chitosan Polymers 0.000 claims description 10
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 10
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 10
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 10
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 9
- YZWKKMVJZFACSU-UHFFFAOYSA-N 1-bromopentane Chemical compound CCCCCBr YZWKKMVJZFACSU-UHFFFAOYSA-N 0.000 claims description 8
- JLBJTVDPSNHSKJ-UHFFFAOYSA-N 4-Methylstyrene Chemical compound CC1=CC=C(C=C)C=C1 JLBJTVDPSNHSKJ-UHFFFAOYSA-N 0.000 claims description 8
- KZCOBXFFBQJQHH-UHFFFAOYSA-N octane-1-thiol Chemical compound CCCCCCCCS KZCOBXFFBQJQHH-UHFFFAOYSA-N 0.000 claims description 8
- ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 claims description 7
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 7
- 229930040373 Paraformaldehyde Natural products 0.000 claims description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 7
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 7
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims description 7
- 229920002866 paraformaldehyde Polymers 0.000 claims description 7
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 7
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 7
- RBACIKXCRWGCBB-UHFFFAOYSA-N 1,2-Epoxybutane Chemical compound CCC1CO1 RBACIKXCRWGCBB-UHFFFAOYSA-N 0.000 claims description 6
- YFZHODLXYNDBSM-UHFFFAOYSA-N 1-ethenyl-4-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(C=C)C=C1 YFZHODLXYNDBSM-UHFFFAOYSA-N 0.000 claims description 6
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 claims description 6
- 239000004166 Lanolin Substances 0.000 claims description 5
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000012065 filter cake Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 229940039717 lanolin Drugs 0.000 claims description 5
- 235000019388 lanolin Nutrition 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 210000002268 wool Anatomy 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 235000011187 glycerol Nutrition 0.000 abstract 2
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 31
- 230000000052 comparative effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000007792 addition Methods 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 229940049964 oleate Drugs 0.000 description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 3
- OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 2
- 238000005886 esterification reaction Methods 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/29—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof
- C07F9/4808—Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof the acid moiety containing a substituent or structure which is considered as characteristic
- C07F9/4841—Aromatic acids or derivatives (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof
- C07F9/4866—Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof the ester moiety containing a substituent or structure which is considered as characteristic
- C07F9/4875—Esters with hydroxy aryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/52—Halophosphines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a high-elasticity moisturizing and anti-aging skin cream and a preparation method thereof, wherein the skin cream comprises the following raw materials in parts by weight: 0.5-0.8 part of carbomer, 5-10 parts of glycerol, 0.2-0.5 part of aminomethyl propanol, 1-2 parts of vitamin C, 0.5-1 part of acetylated hexapeptide, 50-80 parts of deionized water, 1-3 parts of humectant, 1-3 parts of antioxidant, 1-5 parts of squalane, 10-15 parts of olive oil, 3-5 parts of cetyl alcohol, 2-5 parts of microcrystalline wax, 0.5-1 part of isostearyl pivalate and 0.5-0.8 part of dimethyl siloxane; the humectant can be well blended into the moisture of the skin cream, when the skin cream is smeared on the surface of the skin, the cell absorbs the humectant, so that the humectant is decomposed to form citric acid, glycerin and stearic acid, and the cell can accelerate the absorption of the moisture, and the humectant is matched with the rest moisture-keeping components for use, so that the moisturizing effect is better.
Description
Technical Field
The invention relates to the field of preparation of skin care products, in particular to high-elasticity moisturizing and anti-aging skin cream and a preparation method thereof.
Background
All living activities of a human body require energy, and the same energy also plays an important role in the youthful and beautiful health of skin. With the passing of years, the physiological function of a human body is continuously eliminated, and under the influence of adverse factors such as pollution, pressure, ultraviolet rays and the like, particularly the skin energy of modern women can be lost more and more quickly and earlier. The skin age of people depends on whether the skin energy is abundant, so that if the skin energy is continuously lost, the skin age of people is not consistent with the actual physiological age, and if the skin energy is excessively lost and is not timely supplemented, the skin aging signs are more and more obvious, such as wrinkles, color spots, skin relaxation, change of chin contours and other signs are started and continuously worsened.
The existing skin cream has multiple effects, but the moisturizing effect is general, the skin can be kept moist within a short time after the skin cream is applied, but the moisturizing effect cannot be achieved after 1-2 hours, and after the skin cream is placed for a period of time, beneficial ingredients in the skin cream are oxidized, so that the effect of the skin cream is reduced.
Disclosure of Invention
The invention aims to provide a high-elasticity moisturizing and anti-aging skin cream and a preparation method thereof,
the technical problems to be solved by the invention are as follows:
the existing skin cream has multiple effects, but the moisturizing effect is general, the skin can be kept moist within a short time after the skin cream is applied, but the moisturizing effect cannot be achieved after 1-2 hours, and after the skin cream is placed for a period of time, beneficial ingredients in the skin cream are oxidized, so that the effect of the skin cream is reduced.
The purpose of the invention can be realized by the following technical scheme:
the high-elasticity moisturizing and anti-aging skin cream comprises the following raw materials in parts by weight: 0.5-0.8 part of carbomer, 5-10 parts of glycerol, 0.2-0.5 part of aminomethyl propanol, 1-2 parts of vitamin C, 0.5-1 part of acetylated hexapeptide, 50-80 parts of deionized water, 1-3 parts of humectant, 1-3 parts of antioxidant, 1-5 parts of squalane, 10-15 parts of olive oil, 3-5 parts of cetyl alcohol, 2-5 parts of microcrystalline wax, 0.5-1 part of isostearyl pivalate and 0.5-0.8 part of dimethyl siloxane;
the skin cream is prepared by the following steps:
step S1: adding carbomer, glycerol, aminomethyl propanol, vitamin C, acetylated hexapeptide and deionized water into a stirring kettle, and stirring at the rotation speed of 500-;
step S2: adding squalane, olive oil, cetyl alcohol, microcrystalline wax, isostearyl pivalate and dimethyl siloxane into a stirring kettle, and continuously stirring for 1-1.5h under the conditions that the rotating speed is 800-;
step S3: adding the first mixture and the second mixture into a stirring kettle, stirring for 3-5min at a rotation speed of 3000r/min and a temperature of 75-80 ℃, cooling to a temperature of 60 ℃, adding the humectant, the antioxidant and the sodium dodecyl sulfate, continuing stirring for 5-10min, and cooling to room temperature to obtain the skin cream.
Further, the humectant is prepared by the following steps:
step A1: adding citric acid and acetic anhydride into a reaction kettle, stirring and adding concentrated hydrochloric acid under the conditions that the rotation speed is 200-90 ℃ and the temperature is 80-90 ℃, stirring for 5-10min, reacting for 10-15min under the conditions that the temperature is 100-110 ℃ and the pressure is 0.2-0.5MPa, adding oleic acid monoglyceride, continuing to react for 20-30min, heating to the temperature of 120-130 ℃, continuing to react for 40-50min to obtain an intermediate 1, adding the intermediate 1 and stearic acid into the reaction kettle, reacting for 5-8h under the conditions that the rotation speed is 150-200r/min and the temperature is 25-30 ℃ and adding p-toluenesulfonic acid to obtain an intermediate 2;
the reaction process is as follows:
step A2: dissolving carboxymethyl chitosan in deionized water, adding the intermediate 2 prepared in the step A1, reacting for 3-5h at the rotation speed of 200-300r/min and the temperature of 70-80 ℃ under the condition that the pH value of a reaction solution is 5-6, adding a sodium hydroxide solution, stirring for 10-15h at the temperature of 20-25 ℃, adding isopropanol and deionized water, continuing stirring for 5-8h, adding sodium dodecyl benzene sulfonate and epoxybutane, reacting for 10-15h at the temperature of 60-70 ℃, adjusting the pH value of the reaction solution to 7, removing the deionized water, filtering to remove filtrate, and drying a filter cake to obtain the humectant.
Further, the mass ratio of the citric acid, the acetic anhydride and the oleic acid monoglyceride in the step A1 is 1:3:1.5, the mass ratio of the concentrated hydrochloric acid is 0.5-0.8% of the mass ratio of the citric acid, the acetic anhydride and the oleic acid monoglyceride, the mass fraction of the concentrated hydrochloric acid is 36%, the mass molar ratio of the intermediate 1 to the stearic acid is 1:0.8-1, the mass ratio of the p-toluenesulfonic acid is 4-6% of the mass of the intermediate 1, the mass ratio of the carboxymethyl chitosan, the intermediate 2, the sodium hydroxide solution, the isopropanol, the sodium dodecyl benzene sulfonate and the butylene oxide in the step A2 is 30g:15g:50g:100mL:0.1g:200mL, and the mass fraction of the sodium hydroxide solution is 15-20%.
Further, the antioxidant is prepared by the following steps:
step B1: adding phenol and p-toluenesulfonic acid into a reaction kettle, adding methylstyrene at the rotation speed of 150-, carrying out reflux reaction for 3-5h to prepare an intermediate 5;
the reaction process is as follows:
step B2: adding the intermediate 5, iron powder and ethanol into a reaction kettle, performing reflux reaction for 3-5h at the temperature of 80-85 ℃, adding a hydrochloric acid solution for 20min, continuously reacting for 5-8h, adjusting the pH value of a reaction solution to 7-8 to prepare an intermediate 6, adding o-cresol and deionized water into the reaction kettle, stirring at the rotation speed of 150-200r/min at the temperature of 60-70 ℃ until the o-cresol is completely dissolved, adding potassium carbonate and bromopentane, and performing reaction for 20-30min at the temperature of 80 ℃ to prepare an intermediate 7;
the reaction process is as follows:
step B3: adding the intermediate 7, deionized water and potassium permanganate into a reaction kettle, performing reflux reaction for 4-5h under the conditions that the rotation speed is 150-90 r/min and the temperature is 110-120 ℃ to obtain an intermediate 8, adding the intermediate 8, N-octyl mercaptan, paraformaldehyde, N-dimethylformamide and piperidine into the reaction kettle, introducing nitrogen for protection, stirring at the rotation speed of 200-300r/min and the temperature of 80-90 ℃ for 0.5-0.8h, heating to the temperature of 110-115 ℃ for reflux reaction for 8-10h to obtain an intermediate 9, dissolving the intermediate 9 in dimethyl sulfoxide, adding the intermediate 6 and 1-hydroxybenzotriazole, and reacting at the temperature of 25-30 ℃ to obtain an intermediate 10;
the reaction process is as follows:
step B4: adding the intermediate 10, deionized water and potassium permanganate into a reaction kettle, performing reflux reaction for 4-5h at the rotation speed of 150-200r/min and the temperature of 110-120 ℃ to obtain an intermediate 11, dissolving wool in chloroform, adding the intermediate 11 and a sulfuric acid solution at the rotation speed of 200-300r/min and the temperature of 60-70 ℃ to perform reaction for 5-8h, and distilling to remove chloroform to obtain the antioxidant.
The reaction process is as follows:
further, the molar ratio of the phenol, the p-toluenesulfonic acid, the methylstyrene and the 4-nitrostyrene in the step B1 is 1:0.03:1:1.2, the molar ratio of the phosphorus trichloride, the aluminum trichloride and the toluene is 2:1:1, the molar ratio of the intermediate 3, the triethylamine and the intermediate 4 is 2:1:1, the molar ratio of the intermediate 5, the iron powder, the ethanol and the hydrochloric acid solution in the step B2 is 1.8g:4.5g:60mL:15mL, the volume fraction of the ethanol is 90%, the hydrochloric acid solution is formed by mixing concentrated hydrochloric acid with the mass fraction of 36% and ethanol with the volume fraction of 95% in a volume ratio of 1:9, the molar ratio of the o-cresol to the bromopentane is 1:1, the amount of the potassium carbonate is 5-10% of the o-cresol, and the ratio of the intermediate 7, the deionized water and the potassium permanganate in the step B3 is 1.5g:50mL:3.8g, the using amount ratio of the intermediate 8, N-octyl mercaptan, paraformaldehyde, N-dimethylformamide and piperidine is 0.1mol:0.2mol:0.4mol:10mL:1g, the using amount molar ratio of the intermediate 9 to the intermediate 6 is 1:1, the using amount of 1-hydroxybenzotriazole is 20% of the mass of the intermediate 9, the using amount ratio of the intermediate 10, deionized water and potassium permanganate described in the step B4 is 1.8g:70mL:3.4g, the using amount mass ratio of the lanolin alcohol to the intermediate 11 is 5:1, the using amount of the sulfuric acid solution is 15% of the mass of the lanolin alcohol, and the mass fraction of the sulfuric acid solution is 95%.
A preparation method of a high-elasticity moisturizing and anti-aging skin cream specifically comprises the following steps:
step S1: adding carbomer, glycerol, aminomethyl propanol, vitamin C, acetylated hexapeptide and deionized water into a stirring kettle, and stirring at the rotation speed of 500-;
step S2: adding squalane, olive oil, cetyl alcohol, microcrystalline wax, isostearyl pivalate and dimethyl siloxane into a stirring kettle, and continuously stirring for 1-1.5h under the conditions that the rotating speed is 800-;
step S3: adding the first mixture and the second mixture into a stirring kettle, stirring for 3-5min at a rotation speed of 3000r/min and a temperature of 75-80 ℃, cooling to a temperature of 60 ℃, adding the humectant, the antioxidant and the sodium dodecyl sulfate, continuing stirring for 5-10min, and cooling to room temperature to obtain the skin cream.
The invention has the beneficial effects that: the invention prepares a humectant in the process of preparing a high-elasticity moisturizing and anti-aging skin cream, the humectant takes citric acid as a raw material, firstly reacts with acetic anhydride under the action of concentrated hydrochloric acid, then reacts with oleic acid monoglyceride to prepare an intermediate 1, the intermediate 1 reacts with stearic acid under the action of p-toluenesulfonic acid to prepare an intermediate 2, the intermediate 2 and carboxymethyl chitosan are subjected to esterification reaction, so that carboxyl on the carboxymethyl chitosan and hydroxyl on the intermediate 2 are esterified, and then are connected with the carboxymethyl chitosan, and then are subjected to hydroxybutylation to prepare the humectant, the humectant can be well blended into the moisture of the skin cream, when the skin cream is smeared on the surface of skin, cells absorb the humectant, so that the humectant is decomposed to form citric acid, glycerol and stearic acid, and further the cells can accelerate the absorption of the moisture, the antioxidant is used by matching with the rest moisture-keeping components, has better moisture-keeping effect, and simultaneously prepares an antioxidant, wherein phenol is taken as a raw material to react with methyl styrene and 4-nitrostyrene in sequence under the action of p-toluenesulfonic acid to prepare an intermediate 3, phosphorus trichloride reacts with toluene to prepare an intermediate 4, the intermediate 3 and the intermediate 4 react to prepare an intermediate 5, the intermediate 5 is reduced to convert nitro into amino to prepare an intermediate 6, o-cresol is protected by phenolic hydroxyl group with bromopentane to prepare an intermediate 7, the intermediate 7 is oxidized to convert methyl on a benzene ring into carboxyl to prepare an intermediate 8, the intermediate 8 further reacts with n-octyl mercaptan and polyformaldehyde to prepare an intermediate 9, the intermediate 9 and the intermediate 6 are subjected to dehydration condensation to prepare an intermediate 10, the intermediate 10 is oxidized to obtain an intermediate 11, the intermediate 11 and lanolin alcohol are subjected to esterification reaction and deprotection to obtain the antioxidant, the antioxidant molecule contains a plurality of hindered phenol structures, free radicals can be captured, chain reaction is terminated, and aging of the skin cream is prevented, so that effective components in the skin cream cannot lose effectiveness due to long-time placement.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The high-elasticity moisturizing and anti-aging skin cream comprises the following raw materials in parts by weight: 0.5 part of carbomer, 5 parts of glycerol, 0.2 part of aminomethyl propanol, 1 parts of vitamin C, 0.5 part of acetylated hexapeptide, 50 parts of deionized water, 1 part of humectant, 1 part of antioxidant, 1 part of squalane, 10 parts of olive oil, 3 parts of cetyl alcohol, 2 parts of microcrystalline wax, 0.5 part of isostearyl pivalate and 0.5 part of dimethyl siloxane;
the skin cream is prepared by the following steps:
step S1: adding carbomer, glycerol, aminomethyl propanol, vitamin C, acetylated hexapeptide and deionized water into a stirring kettle, and stirring at a rotation speed of 500r/min and a temperature of 80 ℃ for 1h to obtain a first mixture;
step S2: adding squalane, olive oil, cetyl alcohol, microcrystalline wax, isostearyl pivalate and dimethyl siloxane into a stirring kettle, and continuously stirring for 1h at the rotation speed of 800r/min and the temperature of 75 ℃ to prepare a second mixture;
step S3: adding the first mixture and the second mixture into a stirring kettle, stirring for 3min at the rotation speed of 3000r/min and the temperature of 75 ℃, cooling to the temperature of 60 ℃, adding the humectant, the antioxidant and the sodium dodecyl sulfate, continuing stirring for 5min, and cooling to room temperature to obtain the skin cream.
The humectant is prepared by the following steps:
step A1: adding citric acid and acetic anhydride into a reaction kettle, stirring and adding concentrated hydrochloric acid under the conditions of a rotation speed of 200r/min and a temperature of 80 ℃, stirring for 5min, reacting for 10min under the conditions of a temperature of 100 ℃ and a pressure of 0.2MPa, adding monoglycerol oleate, continuing to react for 20min, heating to a temperature of 120 ℃, continuing to react for 40min to obtain an intermediate 1, adding the intermediate 1 and stearic acid into the reaction kettle, adding p-toluenesulfonic acid under the conditions of a rotation speed of 150r/min and a temperature of 25 ℃, and reacting for 5h to obtain an intermediate 2;
step A2: dissolving carboxymethyl chitosan in deionized water, adding the intermediate 2 prepared in the step A1, reacting for 3 hours at the rotation speed of 200r/min and the temperature of 70 ℃ under the condition that the pH value of a reaction solution is 5, adding a sodium hydroxide solution, stirring for 10 hours at the temperature of 20 ℃, adding isopropanol and deionized water, continuing stirring for 5 hours, adding sodium dodecyl benzene sulfonate and epoxybutane, reacting for 10 hours at the temperature of 60 ℃, adjusting the pH value of the reaction solution to 7, removing the deionized water, filtering to remove filtrate, and drying a filter cake to obtain the humectant.
The antioxidant is prepared by the following steps:
step B1: adding phenol and p-toluenesulfonic acid into a reaction kettle, adding methylstyrene at the rotation speed of 150r/min and the temperature of 100 ℃, reacting for 2 hours, adding 4-nitrostyrene, reacting for 2 hours to obtain an intermediate 3, adding phosphorus trichloride and aluminum trichloride into the reaction kettle, stirring and adding toluene at the rotation speed of 200r/min and the temperature of 25 ℃, reacting for 6 hours to obtain an intermediate 4, adding the intermediate 3, triethylamine and toluene into the reaction kettle, stirring at the rotation speed of 120r/min until the temperature of the mixed solution is stable, adding the intermediate 4 at the temperature of 20 ℃, heating to 115 ℃ after the addition is finished, and performing reflux reaction for 3 hours to obtain an intermediate 5;
step B2: adding the intermediate 5, iron powder and ethanol into a reaction kettle, performing reflux reaction for 3 hours at the temperature of 80 ℃, adding a hydrochloric acid solution for 20 minutes, continuously reacting for 5 hours, adjusting the pH value of a reaction solution to 7 to prepare an intermediate 6, adding o-cresol and deionized water into the reaction kettle, stirring at the rotation speed of 150r/min and the temperature of 60 ℃ until the o-cresol is completely dissolved, adding potassium carbonate and bromopentane, and performing reaction for 20 minutes at the temperature of 80 ℃ to prepare an intermediate 7;
step B3: adding the intermediate 7, deionized water and potassium permanganate into a reaction kettle, performing reflux reaction for 4 hours at the rotation speed of 150r/min and the temperature of 110 ℃ to obtain an intermediate 8, adding the intermediate 8, N-octyl mercaptan, paraformaldehyde, N-dimethylformamide and piperidine into the reaction kettle, introducing nitrogen for protection, stirring for 0.5 hour at the rotation speed of 200r/min and the temperature of 80 ℃, heating to the temperature of 110 ℃, performing reflux reaction for 8 hours to obtain an intermediate 9, dissolving the intermediate 9 in dimethyl sulfoxide, adding the intermediate 6 and 1-hydroxybenzotriazole, and reacting at the temperature of 25 ℃ to obtain an intermediate 10;
step B4: adding the intermediate 10, deionized water and potassium permanganate into a reaction kettle, performing reflux reaction for 4 hours at the rotation speed of 150r/min and the temperature of 110 ℃ to obtain an intermediate 11, dissolving wool in chloroform, adding the intermediate 11 and a sulfuric acid solution at the rotation speed of 200r/min and the temperature of 60 ℃, reacting for 5 hours, and distilling to remove chloroform to obtain the antioxidant.
Example 2
The high-elasticity moisturizing and anti-aging skin cream comprises the following raw materials in parts by weight: 0.6 part of carbomer, 8 parts of glycerol, 0.3 part of aminomethyl propanol, 1.5 parts of vitamin C, 0.8 part of acetylated hexapeptide, 60 parts of deionized water, 2 parts of humectant, 2 parts of antioxidant, 3 parts of squalane, 13 parts of olive oil, 4 parts of cetyl alcohol, 3 parts of microcrystalline wax, 0.8 part of isostearyl pivalate and 0.6 part of dimethyl siloxane;
the skin cream is prepared by the following steps:
step S1: adding carbomer, glycerol, aminomethyl propanol, vitamin C, acetylated hexapeptide and deionized water into a stirring kettle, and stirring at a rotation speed of 500r/min and a temperature of 85 ℃ for 1h to obtain a first mixture;
step S2: adding squalane, olive oil, cetyl alcohol, microcrystalline wax, isostearyl pivalate and dimethyl siloxane into a stirring kettle, and continuously stirring for 1.5h at the rotation speed of 1000r/min and the temperature of 75 ℃ to prepare a second mixture;
step S3: adding the first mixture and the second mixture into a stirring kettle, stirring for 5min at a rotating speed of 3000r/min and a temperature of 75 ℃, cooling to a temperature of 60 ℃, adding the humectant, the antioxidant and the sodium dodecyl sulfate, continuing stirring for 5min, and cooling to room temperature to obtain the skin cream.
The humectant is prepared by the following steps:
step A1: adding citric acid and acetic anhydride into a reaction kettle, stirring and adding concentrated hydrochloric acid under the conditions of a rotating speed of 300r/min and a temperature of 80 ℃, stirring for 10min, reacting for 10min under the conditions of a temperature of 100 ℃ and a pressure of 0.5MPa, adding monoglycerol oleate, continuing to react for 30min, heating to a temperature of 120 ℃, continuing to react for 50min to obtain an intermediate 1, adding the intermediate 1 and stearic acid into the reaction kettle, adding p-toluenesulfonic acid under the conditions of a rotating speed of 150r/min and a temperature of 30 ℃, and reacting for 5h to obtain an intermediate 2;
step A2: dissolving carboxymethyl chitosan in deionized water, adding the intermediate 2 prepared in the step A1, reacting for 3 hours at the rotation speed of 300r/min and the temperature of 70 ℃ under the condition that the pH value of a reaction solution is 6, adding a sodium hydroxide solution, stirring for 10 hours at the temperature of 25 ℃, adding isopropanol and deionized water, continuing stirring for 8 hours, adding sodium dodecyl benzene sulfonate and epoxybutane, reacting for 15 hours at the temperature of 60 ℃, adjusting the pH value of the reaction solution to 7, removing the deionized water, filtering to remove filtrate, and drying a filter cake to obtain the humectant.
The antioxidant is prepared by the following steps:
step B1: adding phenol and p-toluenesulfonic acid into a reaction kettle, adding methylstyrene at the rotation speed of 150r/min and the temperature of 110 ℃, reacting for 2 hours, adding 4-nitrostyrene, reacting for 3 hours to obtain an intermediate 3, adding phosphorus trichloride and aluminum trichloride into the reaction kettle, stirring and adding toluene at the rotation speed of 200r/min and the temperature of 30 ℃, reacting for 6 hours to obtain an intermediate 4, adding the intermediate 3, triethylamine and toluene into the reaction kettle, stirring at the rotation speed of 150r/min until the temperature of the mixed solution is stable, adding the intermediate 4 at the temperature of 20 ℃, heating to 120 ℃ after the addition is finished, and performing reflux reaction for 3 hours to obtain an intermediate 5;
step B2: adding the intermediate 5, iron powder and ethanol into a reaction kettle, performing reflux reaction for 3 hours at the temperature of 85 ℃, adding a hydrochloric acid solution for 20 minutes, continuing to react for 8 hours, adjusting the pH value of a reaction solution to 7 to prepare an intermediate 6, adding o-cresol and deionized water into the reaction kettle, stirring at the rotation speed of 200r/min and the temperature of 60 ℃ until the o-cresol is completely dissolved, adding potassium carbonate and bromopentane, and performing reaction for 30 minutes at the temperature of 80 ℃ to prepare an intermediate 7;
step B3: adding the intermediate 7, deionized water and potassium permanganate into a reaction kettle, performing reflux reaction for 4 hours at the rotation speed of 150r/min and the temperature of 120 ℃ to obtain an intermediate 8, adding the intermediate 8, N-octyl mercaptan, paraformaldehyde, N-dimethylformamide and piperidine into the reaction kettle, introducing nitrogen for protection, stirring for 0.8 hour at the rotation speed of 300r/min and the temperature of 80 ℃, heating to the temperature of 110 ℃, performing reflux reaction for 10 hours to obtain an intermediate 9, dissolving the intermediate 9 in dimethyl sulfoxide, adding the intermediate 6 and 1-hydroxybenzotriazole, and reacting at the temperature of 25 ℃ to obtain an intermediate 10;
step B4: adding the intermediate 10, deionized water and potassium permanganate into a reaction kettle, performing reflux reaction for 5 hours at the rotation speed of 200r/min and the temperature of 110 ℃ to obtain an intermediate 11, dissolving wool in chloroform, adding the intermediate 11 and a sulfuric acid solution at the rotation speed of 200r/min and the temperature of 70 ℃ to react for 5 hours, and distilling to remove chloroform to obtain the antioxidant.
Example 3
The high-elasticity moisturizing and anti-aging skin cream comprises the following raw materials in parts by weight: 0.8 part of carbomer, 10 parts of glycerol, 0.5 part of aminomethyl propanol, 2 parts of vitamin C, 1 part of acetylated hexapeptide, 80 parts of deionized water, 3 parts of humectant, 3 parts of antioxidant, 5 parts of squalane, 15 parts of olive oil, 5 parts of cetyl alcohol, 5 parts of microcrystalline wax, 1 part of isostearyl pivalate and 0.8 part of dimethyl siloxane;
the skin cream is prepared by the following steps:
step S1: adding carbomer, glycerol, aminomethyl propanol, vitamin C, acetylated hexapeptide and deionized water into a stirring kettle, and stirring at a rotation speed of 800r/min and a temperature of 85 ℃ for 1.5h to obtain a first mixture;
step S2: adding squalane, olive oil, cetyl alcohol, microcrystalline wax, isostearyl pivalate and dimethyl siloxane into a stirring kettle, and continuously stirring for 1.5h at the rotation speed of 1000r/min and the temperature of 80 ℃ to prepare a second mixture;
step S3: adding the first mixture and the second mixture into a stirring kettle, stirring for 5min at a rotating speed of 3000r/min and a temperature of 80 ℃, cooling to a temperature of 60 ℃, adding the humectant, the antioxidant and the sodium dodecyl sulfate, continuing stirring for 10min, and cooling to room temperature to obtain the skin cream.
The humectant is prepared by the following steps:
step A1: adding citric acid and acetic anhydride into a reaction kettle, stirring and adding concentrated hydrochloric acid under the conditions of a rotating speed of 300r/min and a temperature of 90 ℃, stirring for 10min, reacting for 15min under the conditions of a temperature of 110 ℃ and a pressure of 0.5MPa, adding monoglycerol oleate, continuing to react for 30min, heating to a temperature of 130 ℃, continuing to react for 50min to obtain an intermediate 1, adding the intermediate 1 and stearic acid into the reaction kettle, adding p-toluenesulfonic acid under the conditions of a rotating speed of 200r/min and a temperature of 30 ℃, and reacting for 8h to obtain an intermediate 2;
step A2: dissolving carboxymethyl chitosan in deionized water, adding the intermediate 2 prepared in the step A1, reacting for 5 hours at the rotation speed of 300r/min and the temperature of 80 ℃ under the condition that the pH value of a reaction solution is 6, adding a sodium hydroxide solution, stirring for 15 hours at the temperature of 25 ℃, adding isopropanol and deionized water, continuing stirring for 8 hours, adding sodium dodecyl benzene sulfonate and epoxybutane, reacting for 15 hours at the temperature of 70 ℃, adjusting the pH value of the reaction solution to 7, removing the deionized water, filtering to remove filtrate, and drying a filter cake to obtain the humectant.
The antioxidant is prepared by the following steps:
step B1: adding phenol and p-toluenesulfonic acid into a reaction kettle, adding methylstyrene at the rotation speed of 200r/min and the temperature of 110 ℃, reacting for 3 hours, adding 4-nitrostyrene, reacting for 3 hours to obtain an intermediate 3, adding phosphorus trichloride and aluminum trichloride into the reaction kettle, stirring and adding toluene at the rotation speed of 300r/min and the temperature of 30 ℃, reacting for 8 hours to obtain an intermediate 4, adding the intermediate 3, triethylamine and toluene into the reaction kettle, stirring at the rotation speed of 150r/min until the temperature of the mixed solution is stable, adding the intermediate 4 at the temperature of 25 ℃, heating to 120 ℃ after the addition is finished, and performing reflux reaction for 5 hours to obtain an intermediate 5;
step B2: adding the intermediate 5, iron powder and ethanol into a reaction kettle, performing reflux reaction for 5 hours at the temperature of 85 ℃, adding a hydrochloric acid solution for 20 minutes, continuing to react for 8 hours, adjusting the pH value of a reaction solution to 8 to prepare an intermediate 6, adding o-cresol and deionized water into the reaction kettle, stirring at the rotation speed of 200r/min and the temperature of 70 ℃ until the o-cresol is completely dissolved, adding potassium carbonate and bromopentane, and performing reaction for 30 minutes at the temperature of 80 ℃ to prepare an intermediate 7;
step B3: adding the intermediate 7, deionized water and potassium permanganate into a reaction kettle, performing reflux reaction for 5 hours at the rotation speed of 200r/min and the temperature of 120 ℃ to obtain an intermediate 8, adding the intermediate 8, N-octyl mercaptan, paraformaldehyde, N-dimethylformamide and piperidine into the reaction kettle, introducing nitrogen for protection, stirring for 0.8 hour at the rotation speed of 300r/min and the temperature of 90 ℃, heating to the temperature of 115 ℃, performing reflux reaction for 10 hours to obtain an intermediate 9, dissolving the intermediate 9 in dimethyl sulfoxide, adding the intermediate 6 and 1-hydroxybenzotriazole, and reacting at the temperature of 30 ℃ to obtain an intermediate 10;
step B4: adding the intermediate 10, deionized water and potassium permanganate into a reaction kettle, performing reflux reaction for 5 hours at the rotation speed of 200r/min and the temperature of 120 ℃ to obtain an intermediate 11, dissolving wool in chloroform, adding the intermediate 11 and a sulfuric acid solution at the rotation speed of 300r/min and the temperature of 70 ℃ to react for 8 hours, and distilling to remove chloroform to obtain the antioxidant.
Comparative example
The comparative example is a common skin cream on the market.
Randomly selecting 200 males and females of 18-25 years old, dividing the males into four groups, respectively coating the skin cream prepared in the examples 1-3 on the first group to the third group, coating the skin cream prepared in the comparative example on the fourth group, using the skin cream prepared in the comparative example after cleaning the face in the morning and evening every day, continuously using the skin cream for 30 days to control the moisture rise ratio, the surface viscosity value and the oil control time of the skin, and comparing the free radical scavenging capacity of the skin creams prepared in the examples 1-3 and the comparative example, wherein the results are shown in the following table 1;
TABLE 1
As can be seen from Table 1 above, the skin creams prepared in examples 1-3 have a skin moisture rise ratio of 24.6-25.3%, a surface viscosity of 9.6-9.8, an oil control time of 4.9-5.5h, and are O-sensitive2-The clearance of (b) is 369.59-372.31 mug/mL, the clearance to OH is 7.16-7.28 mug/mL, to H2O2The removing amount of the skin cream is 882.43-900.32 mu g/mL, the removing amount of DPPH is 49.27-51.27 mu g/mL, the removing amount of ABTS is 143.52-145.72 mu g/mL, the skin cream prepared by the comparative example has the skin moisture rising ratio of 12.8 percent, the surface viscosity value of 4.3, the oil control time of 2.1h and the removing amount of O2-The clearance of (a) is 35.71 mu g/mL, and the clearance of OH is0.25. mu.g/mL for H2O2The removing amount of the water-based anti-aging agent is 152.68 mu g/mL, the removing amount of the water-based anti-aging agent for DPPH is 15.34 mu g/mL, and the removing amount of the water-based anti-aging agent for ABTS is 38.47 mu g/mL.
The foregoing is merely exemplary and illustrative of the principles of the present invention and various modifications, additions and substitutions of the specific embodiments described herein may be made by those skilled in the art without departing from the principles of the present invention or exceeding the scope of the claims set forth herein.
Claims (6)
1. A high-elasticity moisturizing and anti-aging skin cream is characterized in that: the feed comprises the following raw materials in parts by weight: 0.5-0.8 part of carbomer, 5-10 parts of glycerol, 0.2-0.5 part of aminomethyl propanol, 1-2 parts of vitamin C, 0.5-1 part of acetylated hexapeptide, 50-80 parts of deionized water, 1-3 parts of humectant, 1-3 parts of antioxidant, 1-5 parts of squalane, 10-15 parts of olive oil, 3-5 parts of cetyl alcohol, 2-5 parts of microcrystalline wax, 0.5-1 part of isostearyl pivalate and 0.5-0.8 part of dimethyl siloxane;
the skin cream is prepared by the following steps:
step S1: adding carbomer, glycerol, aminomethyl propanol, vitamin C, acetylated hexapeptide and deionized water into a stirring kettle, and stirring at the rotation speed of 500-;
step S2: adding squalane, olive oil, cetyl alcohol, microcrystalline wax, isostearyl pivalate and dimethyl siloxane into a stirring kettle, and continuously stirring for 1-1.5h under the conditions that the rotating speed is 800-;
step S3: adding the first mixture and the second mixture into a stirring kettle, stirring for 3-5min at a rotation speed of 3000r/min and a temperature of 75-80 ℃, cooling to a temperature of 60 ℃, adding the humectant, the antioxidant and the sodium dodecyl sulfate, continuing stirring for 5-10min, and cooling to room temperature to obtain the skin cream.
2. The high-elasticity moisturizing and anti-aging skin cream as claimed in claim 1, wherein the high-elasticity moisturizing and anti-aging skin cream is characterized in that: the humectant is prepared by the following steps:
step A1: adding citric acid and acetic anhydride into a reaction kettle, stirring and adding concentrated hydrochloric acid under the conditions that the rotation speed is 200-90 ℃ and the temperature is 80-90 ℃, stirring for 5-10min, reacting for 10-15min under the conditions that the temperature is 100-110 ℃ and the pressure is 0.2-0.5MPa, adding oleic acid monoglyceride, continuing to react for 20-30min, heating to the temperature of 120-130 ℃, continuing to react for 40-50min to obtain an intermediate 1, adding the intermediate 1 and stearic acid into the reaction kettle, reacting for 5-8h under the conditions that the rotation speed is 150-200r/min and the temperature is 25-30 ℃ and adding p-toluenesulfonic acid to obtain an intermediate 2;
step A2: dissolving carboxymethyl chitosan in deionized water, adding the intermediate 2 prepared in the step A1, reacting for 3-5h at the rotation speed of 200-300r/min and the temperature of 70-80 ℃ under the condition that the pH value of a reaction solution is 5-6, adding a sodium hydroxide solution, stirring for 10-15h at the temperature of 20-25 ℃, adding isopropanol and deionized water, continuing stirring for 5-8h, adding sodium dodecyl benzene sulfonate and epoxybutane, reacting for 10-15h at the temperature of 60-70 ℃, adjusting the pH value of the reaction solution to 7, removing the deionized water, filtering to remove filtrate, and drying a filter cake to obtain the humectant.
3. The high-elasticity moisturizing and anti-aging skin cream as claimed in claim 2, wherein the high-elasticity moisturizing and anti-aging skin cream comprises the following components in percentage by weight: the mass ratio of the citric acid, the acetic anhydride and the oleic acid monoglyceride in the step A1 is 1:3:1.5, the mass ratio of the concentrated hydrochloric acid is 0.5-0.8% of the mass ratio of the citric acid, the acetic anhydride and the oleic acid monoglyceride, the mass fraction of the concentrated hydrochloric acid is 36%, the mass molar ratio of the intermediate 1 to the stearic acid is 1:0.8-1, the mass ratio of the p-toluenesulfonic acid is 4-6% of the mass of the intermediate 1, the mass ratio of the carboxymethyl chitosan, the intermediate 2, the sodium hydroxide solution, the isopropanol, the sodium dodecyl benzene sulfonate and the epoxybutane in the step A2 is 30g:15g:50g:100mL:0.1g:200mL, and the mass fraction of the sodium hydroxide solution is 15-20%.
4. The high-elasticity moisturizing and anti-aging skin cream as claimed in claim 1, wherein the high-elasticity moisturizing and anti-aging skin cream is characterized in that: the antioxidant is prepared by the following steps:
step B1: adding phenol and p-toluenesulfonic acid into a reaction kettle, adding methylstyrene at the rotation speed of 150-, carrying out reflux reaction for 3-5h to prepare an intermediate 5;
step B2: adding the intermediate 5, iron powder and ethanol into a reaction kettle, performing reflux reaction for 3-5h at the temperature of 80-85 ℃, adding a hydrochloric acid solution for 20min, continuously reacting for 5-8h, adjusting the pH value of a reaction solution to 7-8 to prepare an intermediate 6, adding o-cresol and deionized water into the reaction kettle, stirring at the rotation speed of 150-200r/min at the temperature of 60-70 ℃ until the o-cresol is completely dissolved, adding potassium carbonate and bromopentane, and performing reaction for 20-30min at the temperature of 80 ℃ to prepare an intermediate 7;
step B3: adding the intermediate 7, deionized water and potassium permanganate into a reaction kettle, performing reflux reaction for 4-5h under the conditions that the rotation speed is 150-90 r/min and the temperature is 110-120 ℃ to obtain an intermediate 8, adding the intermediate 8, N-octyl mercaptan, paraformaldehyde, N-dimethylformamide and piperidine into the reaction kettle, introducing nitrogen for protection, stirring at the rotation speed of 200-300r/min and the temperature of 80-90 ℃ for 0.5-0.8h, heating to the temperature of 110-115 ℃ for reflux reaction for 8-10h to obtain an intermediate 9, dissolving the intermediate 9 in dimethyl sulfoxide, adding the intermediate 6 and 1-hydroxybenzotriazole, and reacting at the temperature of 25-30 ℃ to obtain an intermediate 10;
step B4: adding the intermediate 10, deionized water and potassium permanganate into a reaction kettle, performing reflux reaction for 4-5h at the rotation speed of 150-200r/min and the temperature of 110-120 ℃ to obtain an intermediate 11, dissolving wool in chloroform, adding the intermediate 11 and a sulfuric acid solution at the rotation speed of 200-300r/min and the temperature of 60-70 ℃ to perform reaction for 5-8h, and distilling to remove chloroform to obtain the antioxidant.
5. The high-elasticity moisturizing and anti-aging skin cream according to claim 4, characterized in that: the molar ratio of the dosages of phenol, p-toluenesulfonic acid, methyl styrene and 4-nitrostyrene in the step B1 is 1:0.03:1:1.2, the molar ratio of the dosages of phosphorus trichloride, aluminum trichloride and toluene is 2:1:1, the molar ratio of the dosages of intermediate 3, triethylamine and intermediate 4 is 2:1:1, the molar ratio of the dosages of intermediate 5, iron powder, ethanol and hydrochloric acid solution in the step B2 is 1.8g:4.5g:60mL:15mL, the volume fraction of ethanol is 90%, the hydrochloric acid solution is formed by mixing concentrated hydrochloric acid with the mass fraction of 36% and ethanol with the volume fraction of 95% in a volume ratio of 1:9, the molar ratio of the dosages of o-cresol and bromopentane is 1:1, the dosage of potassium carbonate is 5-10% of the mass of o-cresol, and the dosage ratio of potassium permanganate of intermediate 7, deionized water and potassium permanganate in the step B3 is 1.5g:50mL:3.8g, and the intermediate 8: 1, The using amount ratio of the N-octyl mercaptan, the paraformaldehyde, the N, N-dimethylformamide and the piperidine is 0.1mol:0.2mol:0.4mol:10mL:1g, the using amount molar ratio of the intermediate 9 to the intermediate 6 is 1:1, the using amount of the 1-hydroxybenzotriazole is 20% of the mass of the intermediate 9, the using amount ratio of the intermediate 10, the deionized water and the potassium permanganate described in the step B4 is 1.8g:70mL:3.4g, the using amount mass ratio of the lanolin alcohol to the intermediate 11 is 5:1, the using amount of the sulfuric acid solution is 15% of the mass of the lanolin alcohol, and the mass fraction of the sulfuric acid solution is 95%.
6. The preparation method of the high-elasticity moisturizing and anti-aging skin cream according to claim 1, characterized by comprising the following steps: the method specifically comprises the following steps:
step S1: adding carbomer, glycerol, aminomethyl propanol, vitamin C, acetylated hexapeptide and deionized water into a stirring kettle, and stirring at the rotation speed of 500-;
step S2: adding squalane, olive oil, cetyl alcohol, microcrystalline wax, isostearyl pivalate and dimethyl siloxane into a stirring kettle, and continuously stirring for 1-1.5h under the conditions that the rotating speed is 800-;
step S3: adding the first mixture and the second mixture into a stirring kettle, stirring for 3-5min at a rotation speed of 3000r/min and a temperature of 75-80 ℃, cooling to a temperature of 60 ℃, adding the humectant, the antioxidant and the sodium dodecyl sulfate, continuing stirring for 5-10min, and cooling to room temperature to obtain the skin cream.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108309831A (en) * | 2018-03-21 | 2018-07-24 | 珠海美高美健康科技有限公司 | Face cream and preparation method thereof containing camellia seed oil |
| CN110101634A (en) * | 2019-05-17 | 2019-08-09 | 亚享生物科技(江苏)有限公司 | A kind of astheniz resisting balance frost and preparation method thereof |
| CN111000748A (en) * | 2020-01-08 | 2020-04-14 | 上海瑾亭化妆品有限公司 | Polypeptide repairing cream and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108309831A (en) * | 2018-03-21 | 2018-07-24 | 珠海美高美健康科技有限公司 | Face cream and preparation method thereof containing camellia seed oil |
| CN110101634A (en) * | 2019-05-17 | 2019-08-09 | 亚享生物科技(江苏)有限公司 | A kind of astheniz resisting balance frost and preparation method thereof |
| CN111000748A (en) * | 2020-01-08 | 2020-04-14 | 上海瑾亭化妆品有限公司 | Polypeptide repairing cream and preparation method thereof |
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