CN113332217A - Composite collagen composition for repairing neck shrinkage and sagging - Google Patents
Composite collagen composition for repairing neck shrinkage and sagging Download PDFInfo
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- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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Abstract
The invention discloses a composite collagen composition for repairing neck collapse and sagging, which comprises the following raw materials in parts by weight: 5-8 parts of composite collagen, 1-1.5 parts of whitening emulsion, 2-3 parts of vitamin E, 0.05-0.15 part of sodium hyaluronate, 10-20 parts of olive oil, 1-3 parts of cetyl alcohol and 10-15 parts of deionized water; the composite collagen composition is absorbed by epidermal cells, the modified chitosan acts on cell membranes, the permeability is increased, and further the components with the effects of preventing the skin from being shriveled and drooping are absorbed more thoroughly, meanwhile, a whitening emulsion is prepared in the preparation process, the whitening emulsion takes extracts of radix ophiopogonis, astragalus membranaceus, ligusticum wallichii and radix puerariae as main raw materials, and takes lipid as an oil phase to prepare the whitening emulsion, and the whitening emulsion can inhibit the activity of tyrosinase after being absorbed, so that the generation of melanin is inhibited, and the composite collagen composition has the whitening effect.
Description
Technical Field
The invention relates to the technical field of skin care product preparation, in particular to a composite collagen composition for repairing neck collapse and sagging.
Background
The skin care product is applied on skin, and has effects of moistening and keeping moisture. Especially in dry autumn and winter, the skin care product can increase oil content and moisture of skin, prevent dryness and crack, and moisten skin with luster. However, the components and additives of skin care products vary widely, and the functionality varies with the added components.
Of all skin care products, the anti-aging spectrum is the most expensive and most popular. Scientists and skin care professionals have conducted a great deal of research against aging. Collagen is widely distributed in each tissue of a human body, the synthesis capacity of fibroblasts is reduced along with the increase of the age, if collagen is lacked in the skin, collagen fibers are solidified, intercellular mucopolysaccharide is reduced, the skin loses softness, elasticity and luster, aging occurs, skin shriveling and drooping can be caused seriously, the existing composite collagen composition has a certain skin protection effect, but the effect is general, and the whitening requirement of a user can not be met.
Disclosure of Invention
The invention aims to provide a composite collagen composition for repairing neck collapse and ptosis.
The technical problems to be solved by the invention are as follows:
the existing composite collagen composition has certain skin protection effect, but has general effect and cannot meet the whitening requirement of users.
The purpose of the invention can be realized by the following technical scheme:
a composite collagen composition for repairing neck collapse and sagging comprises the following raw materials in parts by weight: 5-8 parts of composite collagen, 1-1.5 parts of whitening emulsion, 2-3 parts of vitamin E, 0.05-0.15 part of sodium hyaluronate, 10-20 parts of olive oil, 1-3 parts of cetyl alcohol and 10-15 parts of deionized water;
the composite collagen composition is prepared by the following steps:
step S1: adding the composite collagen, the vitamin E and the deionized water into a stirring kettle, and stirring for 1-1.5h at the rotation speed of 500-800r/min and the temperature of 30-50 ℃ to prepare a first mixture;
step S2: adding the whitening emulsion, olive oil, cetyl alcohol and sodium hyaluronate into a stirring kettle, and continuously stirring for 1-1.5 hours at the rotation speed of 800-;
step S3: adding the first mixture and the second mixture into a stirring kettle, and stirring for 3-5min at a rotating speed of 3000r/min and a temperature of 70-80 ℃ to obtain the composite collagen composition.
Further, the composite collagen is prepared by the following steps:
step A1: adding hydrogen peroxide, sodium hydroxide and deionized water into a reaction kettle, stirring and adding fish skin under the condition that the rotating speed is 800-;
step A2: adding fish scales and concentrated hydrochloric acid into a hydrolysis tube, preserving heat for 5-10min at the temperature of-5-0 ℃, introducing nitrogen for protection, preserving heat for 5-7h at the temperature of 110-115 ℃, adding hydrochloric acid, cooling to the temperature of 20-25 ℃, standing for 1-1.5h, adjusting the pH value of the mixed solution to 8-8.5, filtering to obtain a fish scale extracting solution, adding the fish skin extract into the fish scale extracting solution, and uniformly mixing to obtain a composite extracting solution;
step A3: adding chitosan into a sodium hydroxide solution, stirring for 30-40min under the condition of a rotation speed of 200-5 ℃ and a temperature of minus 3-5 ℃, preserving heat for 20-25h to prepare pretreated chitosan, dispersing the pretreated chitosan in ethanol, adding chloroacetic acid under the conditions of a rotation speed of 150-200r/min and a temperature of 50-60 ℃, reacting for 5-7h, cooling to room temperature, filtering to remove filtrate, dissolving a filter cake in deionized water, recrystallizing to prepare modified chitosan, dissolving the modified chitosan in deionized water, adding a composite extracting solution, mixing uniformly under the condition of a temperature of 40-50 ℃, distilling to remove the solvent, and drying a substrate to prepare the composite collagen.
Further, the dosage ratio of the hydrogen peroxide, the sodium hydroxide, the deionized water and the fish skin in the step A1 is 1mL:0.4g:100mL:5g, and the mass fraction of the concentrated sulfuric acid is 95%.
Furthermore, the dosage ratio of the fish scales and the concentrated hydrochloric acid in the step A2 is 3mg:4mL, and the dosage ratio of the fish skin extract and the fish scale extracting solution is 3g:20 mL.
Further, the dosage ratio of the chitosan to the sodium hydroxide solution in the step A3 is 1g:1.5mL, the mass fraction of the sodium hydroxide solution is 50%, the dosage ratio of the pretreated chitosan, the ethanol and the chloroacetic acid is 6g:50mL:1g, and the dosage ratio of the modified chitosan, the deionized water and the composite extracting solution is 1g:6mL:4 mL.
Further, the whitening emulsion is prepared by the following steps:
step B1: pulverizing and mixing radix Ophiopogonis, radix astragali, rhizoma Ligustici Chuanxiong, and radix Puerariae to obtain mixture, adding the mixture and ethanol into a stirring kettle, refluxing for 3 times at a rotation speed of 150-;
step B2: adding dioctyl carbonate and stearic acid into a stirring kettle, stirring for 10-15min at the rotation speed of 200-80 ℃ and the temperature of 75-80 ℃, adding alcohol extract, carrying out reflux stirring for 1-1.5h, cooling to room temperature to prepare an oil phase, dissolving sodium dodecyl benzene sulfonate into deionized water, adding the oil phase, and stirring for 20-30min at the rotation speed of 800-1000r/min to prepare the whitening emulsion.
Further, the dosage mass ratio of the dwarf lilyturf tuber, the astragalus root, the szechuan lovage rhizome and the kudzuvine root in the step B1 is 1:1:1:1, and the dosage ratio of the mixture and the ethanol is 2g:15 mL.
Furthermore, the dosage ratio of the dioctyl carbonate, the stearic acid and the alcohol extract in the step B2 is 5mL:1.5g:3mL, and the dosage ratio of the sodium dodecyl benzene sulfonate, the deionized water and the oil phase is 3g:20mL:15 mL.
The invention has the beneficial effects that: the invention prepares a composite collagen in the process of preparing a composite collagen composition, the composite collagen is prepared by respectively blending fish skin extract and fish scale extract, treating chitosan, so that alcoholic hydroxyl on chitosan molecules reacts with chlorine atom sites on chloroacetic acid molecules to prepare the modified chitosan, when the composite collagen composition is absorbed by epidermal cells, the modified chitosan acts on cell membranes to increase permeability, so as to ensure that the components with the functions of preventing the shriveling and drooping are absorbed more thoroughly, and simultaneously prepare the whitening emulsion in the preparation process, the whitening lotion takes extracts of radix ophiopogonis, astragalus, ligusticum wallichii and radix puerariae as main raw materials, takes lipid as an oil phase to prepare the whitening lotion, the whitening emulsion can inhibit tyrosinase activity after being absorbed, and further inhibit melanin generation, so that the composite collagen composition has whitening effect.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A composite collagen composition for repairing neck collapse and sagging comprises the following raw materials in parts by weight: 5 parts of composite collagen, 1 part of whitening emulsion, 2 parts of vitamin E, 0.05 part of sodium hyaluronate, 10 parts of olive oil, 1 part of cetyl alcohol and 10 parts of deionized water;
the composite collagen composition is prepared by the following steps:
step S1: adding the composite collagen, vitamin E and deionized water into a stirring kettle, and stirring for 1h at the rotation speed of 500r/min and the temperature of 30 ℃ to prepare a first mixture;
step S2: adding the whitening emulsion, olive oil, cetyl alcohol and sodium hyaluronate into a stirring kettle, and continuously stirring for 1h at the rotation speed of 800r/min and the temperature of 75 ℃ to prepare a second mixture;
step S3: and adding the first mixture and the second mixture into a stirring kettle, and stirring for 3min at the rotating speed of 3000r/min and the temperature of 70 ℃ to obtain the composite collagen composition.
The composite collagen is prepared by the following steps:
step A1: adding hydrogen peroxide, sodium hydroxide and deionized water into a reaction kettle, stirring and adding fish skin under the condition that the rotating speed is 800r/min, stirring for 3min, taking out the fish skin, washing the fish skin to be neutral by the deionized water, soaking the fish skin in concentrated sulfuric acid for 20h, centrifuging for 30min under the condition that the rotating speed is 10000r/min, soaking and centrifuging a substrate again by the concentrated sulfuric acid, mixing two supernatants, adding sodium chloride, standing overnight, centrifuging to remove a supernatant, adding the substrate into acetic acid, standing overnight, centrifuging to remove the supernatant, washing the substrate to be neutral by the deionized water, and freeze-drying to obtain a fish skin extract;
step A2: adding fish scales and concentrated hydrochloric acid into a hydrolysis tube, preserving heat for 5min at the temperature of-5 ℃, introducing nitrogen for protection, preserving heat for 5h at the temperature of 110 ℃, adding hydrochloric acid, cooling to the temperature of 20 ℃, standing for 1h, adjusting the pH value of the mixed solution to 8, filtering to obtain a fish scale extracting solution, adding the fish skin extract into the fish scale extracting solution, and uniformly mixing to obtain a composite extracting solution;
step A3: adding chitosan into a sodium hydroxide solution, stirring for 30min at the rotation speed of 200r/min, keeping the temperature at-3 ℃ for 20h to prepare pretreated chitosan, dispersing the pretreated chitosan in ethanol, adding chloroacetic acid at the rotation speed of 150r/min and the temperature of 50 ℃ for reaction for 5h, cooling to room temperature, filtering to remove filtrate, dissolving a filter cake in deionized water, recrystallizing to prepare modified chitosan, dissolving the modified chitosan in deionized water, adding a composite extracting solution, uniformly mixing at the temperature of 40 ℃, distilling to remove a solvent, and drying a substrate to prepare the composite collagen.
The whitening emulsion is prepared by the following steps:
step B1: pulverizing and mixing radix Ophiopogonis, radix astragali, rhizoma Ligustici Chuanxiong, and radix Puerariae to obtain mixture, adding the mixture and ethanol into a stirring kettle, refluxing at 80 deg.C and 150r/min for 3 times, centrifuging for 10min after 2 hr each time at 3000r/min, and collecting substrate to obtain ethanol extract;
step B2: adding dioctyl carbonate and stearic acid into a stirring kettle, stirring for 10min at the rotation speed of 200r/min and the temperature of 75 ℃, adding an alcohol extract, carrying out reflux stirring for 1h, cooling to room temperature to obtain an oil phase, dissolving sodium dodecyl benzene sulfonate into deionized water, adding the oil phase, and stirring for 20min at the rotation speed of 800r/min to obtain the whitening emulsion.
Example 2
A composite collagen composition for repairing neck collapse and sagging comprises the following raw materials in parts by weight: 6 parts of composite collagen, 1.2 parts of whitening emulsion, 2.3 parts of vitamin E, 0.08 part of sodium hyaluronate, 12 parts of olive oil, 1.5 parts of cetyl alcohol and 12 parts of deionized water;
the composite collagen composition is prepared by the following steps:
step S1: adding the composite collagen, vitamin E and deionized water into a stirring kettle, and stirring for 1h at the rotation speed of 500r/min and the temperature of 50 ℃ to prepare a first mixture;
step S2: adding the whitening emulsion, olive oil, cetyl alcohol and sodium hyaluronate into a stirring kettle, and continuously stirring for 1.5 hours at the rotation speed of 1000r/min and the temperature of 75 ℃ to prepare a second mixture;
step S3: and adding the first mixture and the second mixture into a stirring kettle, and stirring for 5min at the rotating speed of 3000r/min and the temperature of 70 ℃ to obtain the composite collagen composition.
The composite collagen is prepared by the following steps:
step A1: adding hydrogen peroxide, sodium hydroxide and deionized water into a reaction kettle, stirring and adding fish skin under the condition that the rotating speed is 800r/min, stirring for 5min, taking out the fish skin, washing the fish skin to be neutral by the deionized water, soaking the fish skin in concentrated sulfuric acid for 20h, centrifuging for 30min under the condition that the rotating speed is 12000r/min, soaking and centrifuging a substrate again by the concentrated sulfuric acid, mixing two supernatants, adding sodium chloride, standing overnight, centrifuging to remove a supernatant, adding the substrate into acetic acid, standing overnight, centrifuging to remove the supernatant, washing the substrate to be neutral by the deionized water, and freeze-drying to obtain a fish skin extract;
step A2: adding fish scales and concentrated hydrochloric acid into a hydrolysis tube, preserving heat for 5min at the temperature of 0 ℃, introducing nitrogen for protection, preserving heat for 5h at the temperature of 115 ℃, adding hydrochloric acid, cooling to the temperature of 25 ℃, standing for 1h, adjusting the pH value of the mixed solution to 8.5, filtering to obtain a fish scale extracting solution, adding the fish skin extract into the fish scale extracting solution, and uniformly mixing to obtain a composite extracting solution;
step A3: adding chitosan into a sodium hydroxide solution, stirring for 40min at the rotation speed of 200r/min, keeping the temperature at-3 ℃ for 25h to prepare pretreated chitosan, dispersing the pretreated chitosan in ethanol, adding chloroacetic acid at the rotation speed of 150r/min and the temperature of 60 ℃ for reaction for 5h, cooling to room temperature, filtering to remove filtrate, dissolving a filter cake in deionized water, recrystallizing to prepare modified chitosan, dissolving the modified chitosan in deionized water, adding a composite extracting solution, uniformly mixing at the temperature of 50 ℃, distilling to remove a solvent, and drying a substrate to prepare the composite collagen.
The whitening emulsion is prepared by the following steps:
step B1: pulverizing and mixing radix Ophiopogonis, radix astragali, rhizoma Ligustici Chuanxiong, and radix Puerariae to obtain mixture, adding the mixture and ethanol into a stirring kettle, refluxing at 90 deg.C and 150r/min for 3 times, centrifuging for 10min after 2 hr each time at 3000r/min, and collecting substrate to obtain ethanol extract;
step B2: adding dioctyl carbonate and stearic acid into a stirring kettle, stirring for 15min at the rotation speed of 300r/min and the temperature of 75 ℃, adding an alcohol extract, carrying out reflux stirring for 1h, cooling to room temperature to prepare an oil phase, dissolving sodium dodecyl benzene sulfonate into deionized water, adding the oil phase, and stirring for 20min at the rotation speed of 1000r/min to prepare the whitening emulsion.
Example 3
A composite collagen composition for repairing neck collapse and sagging comprises the following raw materials in parts by weight: 7 parts of composite collagen, 1.3 parts of whitening emulsion, 2.8 parts of vitamin E, 0.12 part of sodium hyaluronate, 18 parts of olive oil, 2.5 parts of cetyl alcohol and 14 parts of deionized water;
the composite collagen composition is prepared by the following steps:
step S1: adding the composite collagen, vitamin E and deionized water into a stirring kettle, and stirring for 1.5 hours at the rotating speed of 800r/min and the temperature of 30 ℃ to prepare a first mixture;
step S2: adding the whitening emulsion, olive oil, cetyl alcohol and sodium hyaluronate into a stirring kettle, and continuously stirring for 1h at the rotating speed of 800r/min and the temperature of 80 ℃ to prepare a second mixture;
step S3: and adding the first mixture and the second mixture into a stirring kettle, and stirring for 3min at the rotating speed of 3000r/min and the temperature of 80 ℃ to obtain the composite collagen composition.
The composite collagen is prepared by the following steps:
step A1: adding hydrogen peroxide, sodium hydroxide and deionized water into a reaction kettle, stirring and adding fish skin under the condition that the rotating speed is 1000r/min, stirring for 3min, taking out the fish skin, washing the fish skin to be neutral by the deionized water, soaking the fish skin in concentrated sulfuric acid for 25h, centrifuging for 40min under the condition that the rotating speed is 10000r/min, soaking and centrifuging a substrate again by the concentrated sulfuric acid, mixing two supernatants, adding sodium chloride, standing overnight, centrifuging to remove a supernatant, adding the substrate into acetic acid, standing overnight, centrifuging to remove the supernatant, washing the substrate to be neutral by the deionized water, and freeze-drying to obtain a fish skin extract;
step A2: adding fish scales and concentrated hydrochloric acid into a hydrolysis tube, preserving heat for 10min at the temperature of-5 ℃, introducing nitrogen for protection, preserving heat for 7h at the temperature of 110 ℃, adding hydrochloric acid, cooling to the temperature of 20 ℃, standing for 1.5h, adjusting the pH value of the mixed solution to 8, filtering to obtain a fish scale extracting solution, adding the fish skin extract into the fish scale extracting solution, and uniformly mixing to obtain a composite extracting solution;
step A3: adding chitosan into a sodium hydroxide solution, stirring for 30min at the rotation speed of 300r/min, keeping the temperature at minus 5 ℃ for 20h to prepare pretreated chitosan, dispersing the pretreated chitosan in ethanol, adding chloroacetic acid at the rotation speed of 200r/min and the temperature of 50 ℃ for reaction for 7h, cooling to room temperature, filtering to remove filtrate, dissolving a filter cake in deionized water, recrystallizing to prepare modified chitosan, dissolving the modified chitosan in deionized water, adding a composite extracting solution, uniformly mixing at the temperature of 40 ℃, distilling to remove a solvent, and drying a substrate to prepare the composite collagen.
The whitening emulsion is prepared by the following steps:
step B1: pulverizing and mixing radix Ophiopogonis, radix astragali, rhizoma Ligustici Chuanxiong, and radix Puerariae to obtain mixture, adding the mixture and ethanol into a stirring kettle, refluxing at 80 deg.C and 200r/min for 3 times, centrifuging for 15min after 2 hr each time at 3000r/min, and collecting substrate to obtain ethanol extract;
step B2: adding dioctyl carbonate and stearic acid into a stirring kettle, stirring for 10min at the rotation speed of 200r/min and the temperature of 80 ℃, adding an alcohol extract, carrying out reflux stirring for 1.5h, cooling to room temperature to prepare an oil phase, dissolving sodium dodecyl benzene sulfonate into deionized water, adding the oil phase, and stirring for 30min at the rotation speed of 800r/min to prepare the whitening emulsion.
Example 4
A composite collagen composition for repairing neck collapse and sagging comprises the following raw materials in parts by weight: 8 parts of composite collagen, 1.5 parts of whitening emulsion, 3 parts of vitamin E, 0.15 part of sodium hyaluronate, 20 parts of olive oil, 3 parts of cetyl alcohol and 15 parts of deionized water;
the composite collagen composition is prepared by the following steps:
step S1: adding the composite collagen, vitamin E and deionized water into a stirring kettle, and stirring for 1.5 hours at the rotating speed of 800r/min and the temperature of 50 ℃ to prepare a first mixture;
step S2: adding the whitening emulsion, olive oil, cetyl alcohol and sodium hyaluronate into a stirring kettle, and continuously stirring for 1.5 hours at the rotating speed of 1000r/min and the temperature of 80 ℃ to prepare a second mixture;
step S3: and adding the first mixture and the second mixture into a stirring kettle, and stirring for 5min at the rotating speed of 3000r/min and the temperature of 80 ℃ to obtain the composite collagen composition.
The composite collagen is prepared by the following steps:
step A1: adding hydrogen peroxide, sodium hydroxide and deionized water into a reaction kettle, stirring and adding fish skin under the condition that the rotating speed is 1000r/min, stirring for 5min, taking out the fish skin, washing the fish skin to be neutral by the deionized water, soaking the fish skin in concentrated sulfuric acid for 25h, centrifuging for 40min under the condition that the rotating speed is 12000r/min, soaking and centrifuging a substrate again by the concentrated sulfuric acid, mixing two supernatants, adding sodium chloride, standing overnight, centrifuging to remove a supernatant, adding the substrate into acetic acid, standing overnight, centrifuging to remove the supernatant, washing the substrate to be neutral by the deionized water, and freeze-drying to obtain a fish skin extract;
step A2: adding fish scales and concentrated hydrochloric acid into a hydrolysis tube, preserving heat for 10min at the temperature of 0 ℃, introducing nitrogen for protection, preserving heat for 7h at the temperature of 115 ℃, adding hydrochloric acid, cooling to the temperature of 25 ℃, standing for 1.5h, adjusting the pH value of the mixed solution to 8.5, filtering to obtain a fish scale extracting solution, adding a fish skin extract into the fish scale extracting solution, and uniformly mixing to obtain a composite extracting solution;
step A3: adding chitosan into a sodium hydroxide solution, stirring for 40min at the rotation speed of 300r/min, keeping the temperature at minus 5 ℃ for 25h to prepare pretreated chitosan, dispersing the pretreated chitosan in ethanol, adding chloroacetic acid at the rotation speed of 200r/min and the temperature of 60 ℃ for reaction for 7h, cooling to room temperature, filtering to remove filtrate, dissolving a filter cake in deionized water, recrystallizing to prepare modified chitosan, dissolving the modified chitosan in deionized water, adding a composite extracting solution, uniformly mixing at the temperature of 50 ℃, distilling to remove a solvent, and drying a substrate to prepare the composite collagen.
The whitening emulsion is prepared by the following steps:
step B1: pulverizing and mixing radix Ophiopogonis, radix astragali, rhizoma Ligustici Chuanxiong, and radix Puerariae to obtain mixture, adding the mixture and ethanol into a stirring kettle, refluxing at 90 deg.C and 200r/min for 3 times, centrifuging for 15min after 2 hr each time at 3000r/min, and collecting substrate to obtain ethanol extract;
step B2: adding dioctyl carbonate and stearic acid into a stirring kettle, stirring for 15min at the rotation speed of 300r/min and the temperature of 80 ℃, adding an alcohol extract, carrying out reflux stirring for 1.5h, cooling to room temperature to prepare an oil phase, dissolving sodium dodecyl benzene sulfonate into deionized water, adding the oil phase, and stirring for 30min at the rotation speed of 1000r/min to prepare the whitening emulsion.
Comparative example
The comparative example is a collagen composition disclosed in chinese patent CN 101322677A.
200 males and females aged 18 to 25 were randomly selected and divided into four groups, and the collagen compositions prepared in examples 1 to 4 were applied to the first group to the fourth group, respectively, and the collagen compositions prepared in comparative examples were applied to the fifth group, and the neck skin was observed every morning and evening for 30 days, with the results shown in Table 1 below.
TABLE 1
| Example 1 | Example 2 | Example 3 | Example 4 | Comparative example | |
| Whether or not to dry | No dry shriveling | No dry shriveling | No dry shriveling | No dry shriveling | No dry shriveling |
| Whether or not to droop | No sagging occurred | No sagging occurred | No sagging occurred | No sagging occurred | Sag occurred |
| Skin tone | Whitening | Whitening | Whitening | Whitening | Without change |
As can be seen from table 1 above, the composite collagen compositions prepared in examples 1 to 4 have whitening effects while protecting neck skin.
The foregoing is merely exemplary and illustrative of the principles of the present invention and various modifications, additions and substitutions of the specific embodiments described herein may be made by those skilled in the art without departing from the principles of the present invention or exceeding the scope of the claims set forth herein.
Claims (8)
1. A composite collagen composition for repairing neck collapse and ptosis, comprising: the feed comprises the following raw materials in parts by weight: 5-8 parts of composite collagen, 1-1.5 parts of whitening emulsion, 2-3 parts of vitamin E, 0.05-0.15 part of sodium hyaluronate, 10-20 parts of olive oil, 1-3 parts of cetyl alcohol and 10-15 parts of deionized water;
the composite collagen composition is prepared by the following steps:
step S1: adding the composite collagen, the vitamin E and the deionized water into a stirring kettle, and stirring for 1-1.5h at the rotation speed of 500-800r/min and the temperature of 30-50 ℃ to prepare a first mixture;
step S2: adding the whitening emulsion, olive oil, cetyl alcohol and sodium hyaluronate into a stirring kettle, and continuously stirring for 1-1.5 hours at the rotation speed of 800-;
step S3: adding the first mixture and the second mixture into a stirring kettle, and stirring for 3-5min at a rotating speed of 3000r/min and a temperature of 70-80 ℃ to obtain the composite collagen composition.
2. The composite collagen composition for repairing neck collapse and ptosis according to claim 1, wherein: the composite collagen is prepared by the following steps:
step A1: adding hydrogen peroxide, sodium hydroxide and deionized water into a reaction kettle, stirring and adding fish skin under the condition that the rotating speed is 800-;
step A2: adding fish scales and concentrated hydrochloric acid into a hydrolysis tube, preserving heat for 5-10min at the temperature of-5-0 ℃, introducing nitrogen for protection, preserving heat for 5-7h at the temperature of 110-115 ℃, adding hydrochloric acid, cooling to the temperature of 20-25 ℃, standing for 1-1.5h, adjusting the pH value of the mixed solution to 8-8.5, filtering to obtain a fish scale extracting solution, adding the fish skin extract into the fish scale extracting solution, and uniformly mixing to obtain a composite extracting solution;
step A3: adding chitosan into a sodium hydroxide solution, stirring for 30-40min under the condition of a rotation speed of 200-5 ℃ and a temperature of minus 3-5 ℃, preserving heat for 20-25h to prepare pretreated chitosan, dispersing the pretreated chitosan in ethanol, adding chloroacetic acid under the conditions of a rotation speed of 150-200r/min and a temperature of 50-60 ℃, reacting for 5-7h, cooling to room temperature, filtering to remove filtrate, dissolving a filter cake in deionized water, recrystallizing to prepare modified chitosan, dissolving the modified chitosan in deionized water, adding a composite extracting solution, mixing uniformly under the condition of a temperature of 40-50 ℃, distilling to remove the solvent, and drying a substrate to prepare the composite collagen.
3. The composite collagen composition for repairing neck collapse and ptosis according to claim 2, wherein: the dosage ratio of the hydrogen peroxide, the sodium hydroxide, the deionized water and the fish skin in the step A1 is 1mL to 0.4g to 100mL to 5g, and the mass fraction of the concentrated sulfuric acid is 95%.
4. The composite collagen composition for repairing neck collapse and ptosis according to claim 2, wherein: the dosage ratio of the fish scales and the concentrated hydrochloric acid in the step A2 is 3mg:4mL, and the dosage ratio of the fish skin extract and the fish scale extracting solution is 3g:20 mL.
5. The composite collagen composition for repairing neck collapse and ptosis according to claim 2, wherein: the dosage ratio of the chitosan to the sodium hydroxide solution in the step A3 is 1g to 1.5mL, the mass fraction of the sodium hydroxide solution is 50%, the dosage ratio of the pretreated chitosan, the ethanol and the chloroacetic acid is 6g to 50mL to 1g, and the dosage ratio of the modified chitosan, the deionized water and the composite extracting solution is 1g to 6mL to 4 mL.
6. The composite collagen composition for repairing neck collapse and ptosis according to claim 1, wherein: the whitening emulsion is prepared by the following steps:
step B1: pulverizing and mixing radix Ophiopogonis, radix astragali, rhizoma Ligustici Chuanxiong, and radix Puerariae to obtain mixture, adding the mixture and ethanol into a stirring kettle, refluxing for 3 times at a rotation speed of 150-;
step B2: adding dioctyl carbonate and stearic acid into a stirring kettle, stirring for 10-15min at the rotation speed of 200-80 ℃ and the temperature of 75-80 ℃, adding alcohol extract, carrying out reflux stirring for 1-1.5h, cooling to room temperature to prepare an oil phase, dissolving sodium dodecyl benzene sulfonate into deionized water, adding the oil phase, and stirring for 20-30min at the rotation speed of 800-1000r/min to prepare the whitening emulsion.
7. The composite collagen composition for repairing neck collapse and ptosis according to claim 6, wherein: and B1, wherein the dosage mass ratio of the radix ophiopogonis, the astragalus mongholicus, the ligusticum wallichii and the radix puerariae is 1:1:1, and the dosage ratio of the mixture and the ethanol is 2g:15 mL.
8. The composite collagen composition for repairing neck collapse and ptosis according to claim 6, wherein: the dosage ratio of the dioctyl carbonate, the stearic acid and the alcohol extract in the step B2 is 5mL:1.5g:3mL, and the dosage ratio of the sodium dodecyl benzene sulfonate, the deionized water and the oil phase is 3g:20mL:15 mL.
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