CN109303727A - A kind of compound anti-apolexis composition and its application containing plant extracts - Google Patents
A kind of compound anti-apolexis composition and its application containing plant extracts Download PDFInfo
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- CN109303727A CN109303727A CN201811382341.4A CN201811382341A CN109303727A CN 109303727 A CN109303727 A CN 109303727A CN 201811382341 A CN201811382341 A CN 201811382341A CN 109303727 A CN109303727 A CN 109303727A
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- hyaluronate
- aging
- plant extracts
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- apolexis composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The compound anti-apolexis composition and its application, anti-apolexis composition effective component that the invention discloses a kind of containing plant extracts are made of compounding hyaluronate, polypeptide and anti-aging plant extracts.Anti-apolexis composition of the present invention includes the hyaluronate, polypeptide moiety and anti-aging plant extracts of 3 kinds of molecular weight simultaneously, three can concur under the effect of the skin physiologies such as aquation, barrier function, oxidation and inflammation, coordinate synergy, reaches good anti-aging effects.In addition, anti-apolexis composition component type of the present invention is simple, easily prepared, it is easy to be compounded into cosmetics with other compositions, there is the clear superiority for being easy to be added various types formula.
Description
Technical field
The present invention relates to a kind of composition with anti-aging effects and its application, simple more particularly, to a kind of component,
The good composition of anti-aging effects and its application, belong to cosmetic field.
Background technique
Skin aging is a complex process relevant to cutaneous ultrastructure and biochemistry, these variations are endogenous
Aging and extrinsic aging result.UV radiation causes light aging to deepen intrinsic aging process.Factor, the disease of life style
All have an impact with gravity to skin aging.Intrinsic aging be with age and occur ageing process, by each
The inherent cause of people influences.Exogenous aging is primarily referred to as the influence of environmental factor, as active oxygen (ROS), UV irradiate, freely
Base, these factors have summation to skin and collagen and cellular matrix are caused to be degraded.Two kinds of agings all can in skin level and
It is showed on cellular level.
Dupont etc. summarize skin aging epidermis, the performance of dermoepidermal border (DEJ) and corium, agine mechaism,
The approach of comprehensive anti-aging.From the aquation of epidermis, barrier function, oxidation, DNA damage and reparation, energy production,
Oxygenation, immunity, pigmentation, keratinization effect, to the skin aging of dermoepidermal border, then arrive skin corium
Inflammation, microcirculation etc. can all bring the aging of skin.
In the prior art, there is the relevant report of more anti-aging product, such as patent CN201710942352.2 is disclosed
A kind of Sodium Hyaluronate mixture and application thereof, the hyaluronic acid which mentions different molecular weight compounding can have anti-ageing
Old effect.The main mechanism of action of the product of the patent is played comprehensively by the Sodium Hyaluronate mixture of different molecular weight
The effect of moisturizing, and skin moisturizing is a link of anti-aging, cannot play the role of anti-aging comprehensively.Patent
CN201710261734.9 discloses a kind of double-deck Essence and the preparation method and application thereof with maintenance and senile-resistant efficacy,
The Essence is by rilanit special, the poly- trimethicone of methyl, carbonic acid dioctyl ester, cetyl dimethicone, Xiang
Seed oil of sunflower, glycerol, Sodium Hyaluronate, close Luo Mu leaf/stem extraction, the polypeptide containing palmityl tripeptides and palmityl tetrapeptide, lactic acid
Bacillus fermentation lysate, glycosphingolipids, glycerol caprylate and parahydroxyacet-ophenone and the mixture of glycerol monolaurate etc.
Ingredient.The Essence can play maintenance and anti-aging effects, but the formula formulation is special, is only used in specific products.
CN201410714254.X discloses a kind of skin care item with crease-resistant compact and U.S. face moisture-keeping efficacy, by ceramide, three
Peptide -3, gadol extract, Gotu Kola P.E, pomegranate berry extract, hyaluronic acid, rosebud extract, lavender oil,
Soya-bean polypeptides, hamamelis extract, vitamin C composition.The product safety is non-stimulated, has no adverse reaction to human body, can
Moisturizing, nutrition skin prevent pachylosis aging, keep skin bright and new flexible, the function with crease-resistant compact and U.S. face moisturizing
Effect, but it is indefinite that the moisturizing moisturizing effect of the hyaluronic acid of moisture-keeping function in skin is played in this patent, and this skin care item has
Effect ingredient is more, and higher cost, ingredient has lipophilic component and water-soluble composition, prepares relative complex.
It can thus be seen that the cosmetics of current anti-aging or be only capable of acting on one or several anti-aging factors,
Anti-aging effects are not particularly evident, or excessive at being grouped as, at high cost, therefore find that a kind of component is simple, can be directed to
It is very necessary that interior external source reason plays the good composition of more comprehensive anti-aging effects, anti-aging effects.
Summary of the invention
Based on above-mentioned deficiency, the present invention provides a kind of compound anti-apolexis composition containing plant extracts, the composition
Component type simply, between active constituent can be synergistic, highly-safe, can make than more comprehensively providing skin anti-aging
With.
The present invention select compounding hyaluronate, polypeptide and three constituents of anti-aging plant extracts as anti-aging because
Son, by the collaboration of this three collocation, be applied in combination the aquation that can effectively improve skin, barrier function, oxidation and
The effect of the skin physiologies such as inflammation plays more comprehensive anti-aging effects to reach synergistic effect.
Specifically, the present invention provides a kind of compound anti-apolexis composition containing plant extracts, the composition includes anti-
Senescence-factor, the anti-aging factor are made of compounding hyaluronate, polypeptide and anti-aging plant extracts.
Further, the compounding hyaluronate refers to that the mixture of hyaluronate, the hyaluronate are
Soluble-salt of hyaluronic acid, including Sodium Hyaluronate, hyaluronic acid magnesium, zinc hyaluronate, potassium hyaluronate etc. are commonly
Hyaluroni, each hyaluronate effect are similar.Preferably, the compounding hyaluronate used in the present invention refers to 3 kinds
The mixture of the hyaluronate A of different molecular weight, hyaluronate B and hyaluronate C, wherein point of hyaluronate A
Son amount is 1000.1kDa-1800kDa, and the molecular weight of hyaluronate B is 10.1kDa -1000kDa, point of hyaluronate C
Son amount is less than or equal to 10kDa.Hyaluronate A can form one layer of protective cover in skin surface, help improve the barrier function of skin
Can, hyaluronate B and C pass through the aquation that fixed hydrone supports skin, improve skin immunity, while hyaluronic acid
Salt C can increase skin elasticity with Transdermal absorption.The hyaluronate of three kinds of different molecular weights is used in compounding, can be simultaneously in skin
Skin surface layer and deep layer play moisture-keeping function, play anti-aging effects.
Preferably, the molecular weight of the hyaluronate A is 1000.1kDa-1200kDa, the molecule of hyaluronate B
Amount is 500kDa-700kDa, and the molecular weight of hyaluronate C is 3kDa-7kDa.
Preferably, the hyaluronate C is hydrolysis hyaluronate.
Further, the mass ratio of hyaluronate A, hyaluronate B and hyaluronate C are 0.01-0.5:0.01-
0.5:0.01-4, the more preferably mass ratio of hyaluronate A, hyaluronate B and hyaluronate C are 0.05-0.5:
0.05-0.5:0.5-4。
Further, the polypeptide is the mixture of acetyl group hexapeptide -1, palmityl tripeptides and palmityl tetrapeptide.Acetyl group
- 1 pair of MC1-R antibody of hexapeptide has affinity, is a kind of bionic peptide for simulating α-MSH, can be by conjunction with MC1-R antibody
Promote melanin production, therefore is a kind of natural light protective factors and inflammation modulators；Palmityl tripeptides belong to signal peptide, energy
Promote the generation of collagen and other extracellular matrix proteins；Palmityl tetrapeptide can stimulate skin true as a kind of courier's peptide
The synthesis and development of collagen (I type, II type, IV type) and elastin laminin in cortex have good crease-resistant anti-inflammatory effect.
Further, the mass ratio of acetyl group hexapeptide -1, palmityl tripeptides and palmityl tetrapeptide is 1-10:0.5-5:0.5-
5, the preferably mass ratio of acetyl group hexapeptide -1, palmityl tripeptides and palmityl tetrapeptide is 5-10:1-5:1-5.
Further, the anti-aging plant extracts is Gotu Kola P.E, cranberry extract, green-tea extract and silver
The mixture of apricot extract.Gotu Kola P.E is a kind of heteroside, mainly plays adjustment effect on three levels, logical first
It crosses control and adjusts and be immunized the-related inflammation transfer medium of excitation, inhibit skin chronic inflammation, certainly secondly by decaying inflammation
Dynamic amplification circulation, rebalances their natural renovation, makes keratinocyte hyperproliferative normalization, finally by connective group
The expression of cell collagen is knitted, corium extracellular matrix is reconstructed.Blueberry scientific name Vacciniumspp., ericad, cranberry extract
Object is former rich in anthocyanidin, has and eliminates free radical antioxidant effect well, can effectively inhibit the decomposition of collagen, reduces collagen
The effect of impaired loss of albumen, suitable for anti-aging, anti-oxidant, whitening, removes the products such as scar.Blueberry kind have 130 kinds with
On, mainly there are wineberry, lagophthalmos cowberry, narrow leaf cowberry, Australia cowberry, mossberry etc., has in the blueberry of different cultivars anti-
Aging ingredient, preferably wineberry.Wineberry, that is, blueberry is a kind of darkviolet fruit, is rich in anthocyanidin, is had extremely strong anti-
Oxidation.Anthocyanidin is a kind of biological flavone, has antioxidant action, and freezing wineberry annual can save.According to
The analysis of Tufts university of the U.S., in 40 kinds of vegetables and fruit with antioxidant effect, the anthocyanidin of wineberry
(Anthocyanosides) content ranks the first.Anthocyanidin contained by wineberry is contained among all fruit and vegetables
Measure highest, and the most abundant part of the anthocyanidin of wineberry is exactly at its distinctive purple pericarp position.Green-tea extract
Polyphenols is mainly contained, there is the characteristic and outstanding astriction for removing free radical, have good antioxidation, together
When have anti-inflammatory, immunoprotection and other effects.Most scientific result of study shows the natural materials ingredient retained in green tea to health care
Always, anti-cancer, anticancer, sterilization, anti-inflammatory etc. have special-effect, for less than fermentation class tea etc..Ginkgo biloba extract contains Gingko yellow
Ketone, ginkgoterpene lactone.GINKGO BILOBA EXTRACT can induce the expression of antioxidase GCLC, and can directly remove superoxide anion and hydroxyl freedom
Base has promoting blood circulation, activating cell, anti-aging, radical ion agent for capturing, promotes skin collagen to generate, restores skin bullet
Property antiallergy, alleviates pain, is anti-inflammatory, the functions such as whitening.Chinese medicine thinks that ginkgo leaf has the effect of beauty treatment black hair, promote longevity.
Preferably, the mass ratio of Gotu Kola P.E, cranberry extract, green-tea extract and ginkgo biloba extract is 1-10:
1-10:1-10:1-10.
Further, dosage of each component in the anti-aging factor are as follows: compounding hyaluronate 0.03-5 parts by weight, polypeptide
2-20 parts by weight, anti-aging plant extracts 4-40 parts by weight.Preferably, dosage of each component in the anti-aging factor are as follows: compounding is saturating
Bright matter hydrochlorate 0.6-5 parts by weight, polypeptide 7-20 parts by weight, anti-aging plant extracts 4-40 parts by weight.
Further, the compound anti-apolexis composition containing plant extracts further includes base other than the anti-aging factor
Plinth component, the anti-aging factor are scattered in basic components.The effect of the basic components is solvent and anti-corrosion, basic components
The preferably mixture of water, glycerol, butanediol and pentanediol, it is furthermore preferred that glycerol: butanediol: the mass ratio of pentanediol is 2-
5:5-10:3-8, water supply surplus.
The present invention will compound hyaluronate, polypeptide and anti-aging plant extracts and compound as the anti-aging factor,
It solves the reason of skin aging from various aspects such as replenishing water and preserving moisture, barrier action, oxidation and inflammation, plays relatively comprehensively anti-
The effect of aging.Compound anti-apolexis composition of the present invention containing plant extracts can be used as anti-aging for cosmetics
In, application of the compound anti-apolexis composition in cosmetics for the present invention containing plant extracts is also within protection scope.
The cosmetics may include toner, Essence, lotion, cream, facial mask etc..
Further, the present invention also provides a kind of cosmetics with anti-aging effects, which contains containing above-mentioned
The compound anti-apolexis composition of plant extracts, content of the anti-aging factor in cosmetics is preferably 5-30wt%.Makeup
The type of product is as set forth above, it is possible to be toner, Essence, lotion, cream, facial mask etc..
Compound anti-apolexis composition of the present invention containing plant extracts includes the hyaluronate, more of 3 kinds of molecular weight simultaneously
Peptide components and anti-aging plant extracts, three can be from skin physiologies such as aquation, barrier function, oxidation and inflammation
It is concured under effect, coordinates synergy, reach good anti-aging effects.In addition, the present invention is containing the compound of plant extracts
Anti-apolexis composition component type is simple, easily prepared, is easy to be compounded into cosmetics with other compositions, has and is easy to be added respectively
The clear superiority of seed type formula.
Specific embodiment
Technical solution and advantage in order to better illustrate the present invention make the present invention below in conjunction with specific embodiment
It further illustrates.It should be noted that the unspecified technological parameter of the present invention, raw material etc. are according to this field routine techniques
Means carry out.
The present invention provides a kind of compound anti-apolexis composition containing plant extracts comprising the anti-aging factor, it is described
The anti-aging factor is made of compounding hyaluronate, polypeptide and anti-aging plant extracts.Wherein, compounding hyaluronate is 3
The hyaluronate A of different molecular weight, the mixture of hyaluronate B and hyaluronate C are planted, polypeptide is acetyl group hexapeptide-
1, the mixture of palmityl tripeptides and palmityl tetrapeptide, anti-aging plant extracts is Gotu Kola P.E, cranberry extract, green
The mixture of tea extraction and ginkgo biloba extract.
Further, the molecular weight of hyaluronate A is 1000.1kDa-1800kDa, such as 1000.1kDa-
1200kDa, 1200kDa-1500kDa, 1500kDa-1800kDa, 1000.1kDa-1500kDa, preferably 1000.1kDa-
1200kDa.The molecular weight of hyaluronate B is 10.1kDa -1000kDa, such as 10.1kDa-100kDa, 100kDa-
200kDa, 200kDa-400kDa, 400kDa-500kDa, 500kDa-700kDa, 700kDa-1000kDa, preferably 500kDa-
700kDa.The molecular weight of hyaluronate C is less than or equal to 10kDa, such as 3kDa-5kDa, 5kDa-7kDa, 7kDa-10kDa, excellent
It is selected as 3kDa-7kDa.
Further, the mass ratio of hyaluronate A, hyaluronate B and hyaluronate C are 0.01-0.5:0.01-
0.5:0.01-4, preferably 0.05-0.5:0.05-0.5:0.5-4.In the specific embodiment of the invention, hyaluronate A,
The mass ratio of hyaluronate B and hyaluronate C are 0.01:0.01:0.01,0.01:0.5:4,0.5:0.01:0.01,
0.05:0.05:0.5,0.5:0.5:4,0.1:0.1:4,0.4:0.3:0.5,0.1:0.05:1 or 0.2:0.5:0.5.
Further, the mass ratio of acetyl group hexapeptide -1, palmityl tripeptides and palmityl tetrapeptide is 1-10:0.5-5:0.5-
5, preferably 5-10:1-5:1-5.In the specific embodiment of the invention, acetyl group hexapeptide -1, palmityl tripeptides and palmityl four
The mass ratio of peptide be 1:0.5:0.5,1:5:5,10:1:1,10:0.5:1,5:5:5,5:5:1,10:5:5,5:1:1,9:2:3 or
6:4:1。
Further, the mass ratio of Gotu Kola P.E, cranberry extract, green-tea extract and ginkgo biloba extract is 1-
10:1-10:1-10:1-10.In the specific embodiment of the invention, Gotu Kola P.E, cranberry extract, green-tea extract and
The mass ratio of ginkgo biloba extract is 1:1:1:1,1:10:1:10,10:1:10:1,5:5:10:10,1:1:5:5,1:4:9:2,3:
8:5:4,6:2:3:10 or 10:5:2:1.
Further, the dosage relation of hyaluronate, polypeptide and anti-aging plant extracts is compounded are as follows: compounding hyalomitome
Hydrochlorate 0.03-5 parts by weight, polypeptide 2-20 parts by weight, anti-aging plant extracts 4-40 parts by weight, preferably are as follows: compounding hyalomitome
Hydrochlorate 0.6-5 parts by weight, polypeptide 7-20 parts by weight, anti-aging plant extracts 4-40 parts by weight.In a certain specific reality of the present invention
It applies in mode, compounds 0.03 parts by weight of hyaluronate, 20 parts by weight of polypeptide, 20 parts by weight of anti-aging plant extracts.At this
It invents in a certain specific embodiment, compounds 5 parts by weight of hyaluronate, 2 parts by weight of polypeptide, 4 weight of anti-aging plant extracts
Measure part.In a certain specific embodiment of the present invention, 0.3 parts by weight of hyaluronate, 10 parts by weight of polypeptide are compounded, anti-aging is planted
30 parts by weight of object extract.In a certain specific embodiment of the present invention, 3 parts by weight of hyaluronate, 5 weight of polypeptide are compounded
Part, 10 parts by weight of anti-aging plant extracts.In a certain specific embodiment of the present invention, 0.6 weight of hyaluronate is compounded
Part, 7 parts by weight of polypeptide, 40 parts by weight of anti-aging plant extracts.In a certain specific embodiment of the present invention, hyalomitome is compounded
4.2 parts by weight of hydrochlorate, 15 parts by weight of polypeptide, 16 parts by weight of anti-aging plant extracts.In a certain specific embodiment of the present invention
In, compound 0.8 parts by weight of hyaluronate, 14 parts by weight of polypeptide, 20 parts by weight of anti-aging plant extracts.It is a certain in the present invention
In specific embodiment, 1.12 parts by weight of hyaluronate, 7.5 parts by weight of polypeptide, 21 weight of anti-aging plant extracts are compounded
Part.In a certain specific embodiment of the present invention, 0.8 parts by weight of hyaluronate, 20 parts by weight of polypeptide, anti-aging plant are compounded
5 parts by weight of extract.In a certain specific embodiment of the present invention, 4.11 parts by weight of hyaluronate, 11 weight of polypeptide are compounded
Part, 16 parts by weight of anti-aging plant extracts.
Further, compound anti-apolexis composition of the present invention containing plant extracts further includes base in addition to the anti-aging factor
Plinth component, the anti-aging factor are scattered in basic components；The basic components are to be usually used in cosmetics in the prior art
Basic components, such as solvent, preservative etc., basic components are preferably the mixture of water, glycerol, butanediol and pentanediol.Institute
The various productions such as toner, Essence, lotion, cream, facial mask can be made by stating the compound anti-apolexis composition containing plant extracts
Product, product preparation method is according to each cosmetics conventional method disclosed in the prior art.
Several preferred embodiments of the invention are set forth below, it is following to be further expalined and to illustrate to the present invention
In embodiment, unless otherwise instructed, each Ingredient Amount is parts by weight.
In following embodiments, Gotu Kola P.E used, Vaccinium myrtillus extract, green-tea extract and ginkgo biloba extract
It is all from commercially available.
Embodiment 1
Compound anti-apolexis composition of the present invention containing plant extracts is made of basic components and the anti-aging factor, the base set
It is divided into deionized water, glycerol, butanediol, pentanediol, the anti-aging factor is that compounding Sodium Hyaluronate, polypeptide and anti-aging plant mention
Object is taken, the compound anti-apolexis composition formula containing plant extracts is (parts by weight): 4.2 parts of Sodium Hyaluronate of compounding, polypeptide 15
Part, 16 parts of anti-aging plant extracts, 2 parts of glycerol, 5 parts of butanediol, 4 parts of pentanediol, 53.8 parts of deionized water；Wherein, it compounds
Sodium Hyaluronate by mass ratio 0.1:0.1:4 molecular weight 1000.1kDa-1200kDa Sodium Hyaluronate A, molecular weight
The Sodium Hyaluronate C of the Sodium Hyaluronate B and molecular weight 3kDa-7kDa of 500kDa-700kDa are formed；Polypeptide is by mass ratio 5:5:
5 acetyl group hexapeptide -1, palmityl tripeptides and palmityl tetrapeptide composition；Anti-aging plant extracts is by mass ratio 1:4:9:2's
Gotu Kola P.E, Vaccinium myrtillus extract, green-tea extract and ginkgo biloba extract composition.
The above-mentioned compound anti-apolexis composition containing plant extracts the preparation method comprises the following steps: weighing deionized water is heated to 90
DEG C, 50 DEG C are then cooled to, is added after hyaluronate is uniformly dispersed with glycerol, butanediol and pentanediol, is stirred
It is even；Then it is cooled to 45 DEG C or less addition polypeptides and anti-aging plant extracts, is cooled to room temperature after being uniformly mixed, as
Compound anti-apolexis composition containing plant extracts.
Embodiment 2
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is multiple
With Sodium Hyaluronate by mass ratio 0.4:0.3:0.5 molecular weight 1000.1kDa-1200kDa Sodium Hyaluronate A, molecular weight
The Sodium Hyaluronate C of the Sodium Hyaluronate B and molecular weight 3kDa-7kDa of 500kDa-700kDa are formed.
Embodiment 3
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is multiple
With Sodium Hyaluronate by mass ratio 0.1:0.05:1 molecular weight 1000.1kDa-1200kDa Sodium Hyaluronate A, molecular weight
The Sodium Hyaluronate C of the Sodium Hyaluronate B and molecular weight 3kDa-7kDa of 500kDa-700kDa are formed.
Embodiment 4
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is multiple
With Sodium Hyaluronate by mass ratio 0.2:0.5:0.5 molecular weight 1000.1kDa-1200kDa Sodium Hyaluronate A, molecular weight
The Sodium Hyaluronate C of the Sodium Hyaluronate B and molecular weight 3kDa-7kDa of 500kDa-700kDa are formed.
Embodiment 5
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is more
Peptide is made of the acetyl group hexapeptide -1 of mass ratio 9:2:3, palmityl tripeptides and palmityl tetrapeptide.
Embodiment 6
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is more
Peptide is made of the acetyl group hexapeptide -1 of mass ratio 5:1:1, palmityl tripeptides and palmityl tetrapeptide.
Embodiment 7
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is more
Peptide is made of the acetyl group hexapeptide -1 of mass ratio 6:4:1, palmityl tripeptides and palmityl tetrapeptide.
Embodiment 8
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is anti-
Aging plant extracts is mentioned by the Gotu Kola P.E of mass ratio 3:8:5:4, Vaccinium myrtillus extract, green-tea extract and ginkgo
Object is taken to form.
Embodiment 9
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is anti-
Aging plant extracts is by the Gotu Kola P.E of mass ratio 6:2:3:10, Vaccinium myrtillus extract, green-tea extract and ginkgo
Extract composition.
Embodiment 10
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is anti-
Aging plant extracts is by the Gotu Kola P.E of mass ratio 10:5:2:1, Vaccinium myrtillus extract, green-tea extract and ginkgo
Extract composition.
Embodiment 11
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is multiple
With 0.8 part of Sodium Hyaluronate, 14 parts of polypeptide, 20 parts of anti-aging plant extracts, 4 parts of glycerol, 6 parts of butanediol, 5 parts of pentanediol,
50.2 parts of deionized water.
Embodiment 12
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is multiple
With 1.12 parts of Sodium Hyaluronate, 7.5 parts of polypeptide, 21 parts of anti-aging plant extracts, 4 parts of glycerol, 5 parts of butanediol, pentanediol 3
Part, 58.38 parts of deionized water.
Embodiment 13
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is multiple
With 0.6 part of Sodium Hyaluronate, 7 parts of polypeptide, 40 parts of anti-aging plant extracts, 2 parts of glycerol, 10 parts of butanediol, 8 parts of pentanediol,
32.4 parts of deionized water.
Embodiment 14
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is multiple
With 0.8 part of Sodium Hyaluronate, 20 parts of polypeptide, 5 parts of anti-aging plant extracts, 2 parts of glycerol, 4 parts of butanediol, 8 parts of pentanediol, go
60.2 parts of ionized water.
Embodiment 15
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: it is multiple
With 4.11 parts of Sodium Hyaluronate, 11 parts of polypeptide, 16 parts of anti-aging plant extracts, 5 parts of glycerol, 6 parts of butanediol, 3 parts of pentanediol,
54.89 parts of deionized water.
Embodiment 16
The component of compound anti-apolexis composition containing plant extracts, formula and the preparation method is the same as that of Example 1, unlike: thoroughly
The molecular weight of bright matter hydrochlorate A is 1500kDa-1800kDa, and the molecular weight of hyaluronate B is 100kDa -500kDa, hyalomitome
The molecular weight of hydrochlorate C is 5kDa-10kDa.
Comparative example 1
The component of compound anti-apolexis composition, formula and the preparation method is the same as that of Example 1, unlike: compounding Sodium Hyaluronate by
The hyalomitome of the Sodium Hyaluronate A of the molecular weight 1000kDa-1200kDa of mass ratio 0.1:0.1, molecular weight 500kDa-700kDa
Sour sodium B.
Comparative example 2
The component of compound anti-apolexis composition, formula and the preparation method is the same as that of Example 1, unlike: compounding Sodium Hyaluronate is
The Sodium Hyaluronate B1 of 0.1 part of the Sodium Hyaluronate A1 of molecular weight 2000-2500kDa, molecular weight 1000kDa-1500kDa
0.1 part, 4 parts of Sodium Hyaluronate C1 of molecular weight 9kDa-20kDa compositions.
Comparative example 3
The component of compound anti-apolexis composition, formula and the preparation method is the same as that of Example 1, unlike: polypeptide is by mass ratio 5:5:5
Argireline: tripeptides -1: carnosine composition.
Comparative example 4
The component of compound anti-apolexis composition, formula and the preparation method is the same as that of Example 1, unlike: the polypeptide is by mass ratio
The acetyl group hexapeptide -1 and palmityl tetrapeptide of 5:5 forms.
Comparative example 5
The component of compound anti-apolexis composition, formula and the preparation method is the same as that of Example 1, unlike: it is mentioned without anti-aging plant
Take object.
Comparative example 6
The component of compound anti-apolexis composition, formula and the preparation method is the same as that of Example 1, unlike: anti-aging plant extracts
It is made of the Gotu Kola P.E of mass ratio 1:2, Vaccinium myrtillus extract.
Application examples
The compound anti-apolexis composition containing plant extracts of the above embodiment of the present invention preparation can be used as anti-aging use
In cosmetics, content in cosmetics can be 5-30wt%, for example, 5wt%, 10wt%, 15wt%, 20wt%, 25wt%,
30wt%。
The experiment of 1 hydroxyl radical free radical clearance rate of experimental example
Method: take the ethanol solution that 1 .0mL concentration is the Phen of 1 .865mmol/L in test tube with ground stopper, respectively
The compound anti-ageing of each embodiment and comparative example of phosphate buffer 2mL and 1mL for the pH 7.4 that concentration is 0.2mol/L is added
The FeSO that 1.0mL concentration is 1.865mmol/L is added in old composition after mixing well4·7H2O solution is added 1 after mixing again
.0mL the H of 0 .03% (v/v)2O2, after 37 DEG C of waters bath with thermostatic control, 60min, measure each group mixed solution respectively at 536nm
Absorbance value obtains A1, replaces sample embodiment and comparative example composition to survey absorbance value as blank group using distilled water, obtains A2, to steam
Distilled water substitutes H2O2As damage group, surveying its absorbance value is A3, and the clearance rate of the hydroxyl radical free radical of sample is counted as follows
It calculates: hydroxyl radical free radical clearance rate (%)=[(A1-A3)/(A2-A3)] × 100% and takes the average value measured three times, detection knot
Fruit is as shown in table 1.
The experiment of 2 DPPH free radical scavenging activity of experimental example
Method: it takes the DPPH- absolute methanol solution that 3mL concentration is 0 .0178mmol/L in cuvette, it is each to add 3mL
The compound anti-apolexis composition of embodiment and comparative example, mixes and surveys light absorption value survey at 517nm wavelength immediately, and light absorption value is denoted as
A1, then light absorption value is surveyed after 30min is kept in dark place at 37 DEG C, it is denoted as A2, blank control is only to add DPPH- absolute methanol solution,
Its light absorption value is denoted as A3.It is calculated as follows DPPH free radical scavenging activity: DPPH free radical scavenging activity (%)=[1- (A1-A2)/
A3] × 100%, the average value measured three times is taken, testing result is as shown in table 1.
1 data of table are analyzed, can be seen that compound anti-apolexis composition of the invention has very well from embodiment 1-16
Hydroxyl radical free radical clearance rate and DPPH free radical scavenging activity, from comparative example 1-6 can be seen that change the present composition it is saturating
Hydroxyl radical free radical clearance rate and DPPH free radical scavenging activity, therefore this hair can be all reduced after bright matter hydrochlorate molecular weight, constituent species
Bright Sodium Hyaluronate, polypeptide and plant extracts three have apparent synergy, have better senile-resistant efficacy.
3 normal individual trial evaluation experimental of experimental example
In order to verify the effect of the compound anti-apolexis composition of the present invention, the following experiment of progress:
1, the preparation of sample
Test sample 1-3: the compound anti-apolexis composition 20g of Example 1,11,14 respectively adds purified water to 100ml, and stirring is equal
It is even, sample 1-3 must be tested；
Control sample 1-3: taking the compound anti-apolexis composition 20g of comparative example 2,3,6 respectively, adds purified water to 100ml, and stirring is equal
It is even, obtain control sample 1-3.
, anti-wrinkle evaluation experimental
Experiment sample 1 is subjected to check experiment with experiment sample 2, experiment sample 3, control sample 1-3 respectively, by the way of the control of half face,
One side of something smears laboratory sample, and one side of something smears control sample.Totally 5 groups of volunteer, every group 20, the age 30-50 years old, men and women was unlimited.
Every group for each person every day half face smear 2g experiment product (experiment sample 1) and half face smear 2g reference substance (test sample 2,3 and control sample 1-3,
Every group of reference substance is different), anti-wrinkle effect expedition 4 weeks, before measurement is smeared respectively, 1 day, 1 week, 2 weeks, 3 weeks and 4 weeks after smearing
Wrinkle depth, is averaged for duplicate measurements 3 times, calculates wrinkle mean depth (Sa) relative mean values.
The sum of wrinkle mean depth (Sa) relative value of wrinkle mean depth (Sa) relative mean values=each sample/use
Number × 100% of the sample
Wrinkle mean depth after wrinkle mean depth (Sa) relative value (%)=everyone smearing/everyone smear before wrinkle mean depth ×
100%
Laboratory apparatus: human skin rapid three dimensional imaging system (PRIMOS, Germany), anti-wrinkle Contrast on effect see the table below 2.
From 2 experimental result of table as it can be seen that the Sa relative mean values of experiment sample 1-3 are less than control sample 1-3, it may be said that Ming Benfa
The replacement and deletion of every kind of ingredient in bright composition can all influence the senile-resistant efficacy of composition, compound anti-aging of the invention
Composition, which is scattered in purified water, can good anti-ageing effect, also illustrate that the present invention is easy to be added to as stock dispersion
In other cosmetic formulations.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of compound anti-apolexis composition containing plant extracts, it is characterized in that: include the anti-aging factor, the anti-aging because
Son is made of compounding hyaluronate, polypeptide and anti-aging plant extracts.
2. compound anti-apolexis composition according to claim 1, it is characterized in that: the compounding hyaluronate be 3 kinds not
With the mixture of the hyaluronate A of molecular weight, hyaluronate B and hyaluronate C, the molecular weight of hyaluronate A is
The molecular weight of 1000.1kDa-1800kDa, hyaluronate B are 10.1kDa -1000kDa, and the molecular weight of hyaluronate C is small
In equal to 10kDa；Preferably, the molecular weight of the hyaluronate A is 1000.1kDa-1200kDa, hyaluronate B's
Molecular weight is 500kDa-700kDa, and the molecular weight of hyaluronate C is 3kDa-7kDa；Preferably, the hyaluronate C
To hydrolyze hyaluronate；Preferably, the hyaluronate include Sodium Hyaluronate, hyaluronic acid magnesium, zinc hyaluronate, thoroughly
Bright matter acid potassium, preferably Sodium Hyaluronate.
3. compound anti-apolexis composition according to claim 2, it is characterized in that: hyaluronate A, hyaluronate B and
The mass ratio of hyaluronate C is 0.01-0.5:0.01-0.5:0.01-4, preferably 0.05-0.5:0.05-0.5:0.5-4.
4. compound anti-apolexis composition according to claim 1, it is characterized in that: the polypeptide is acetyl group hexapeptide -1, palm fibre
The mixture of palmitic acid acyl tripeptides and palmityl tetrapeptide, it is preferred that the quality of acetyl group hexapeptide -1, palmityl tripeptides and palmityl tetrapeptide
Than for 1-10:0.5-5:0.5-5, more preferably 5-10:1-5:1-5；The anti-aging plant extracts be Gotu Kola P.E,
The mixture of cranberry extract, green-tea extract and ginkgo biloba extract, it is preferred that Gotu Kola P.E, cranberry extract, green tea
The mass ratio of extract and ginkgo biloba extract is 1-10:1-10:1-10:1-10.
5. compound anti-apolexis composition described in any one of -4 according to claim 1, it is characterized in that: each group in the anti-aging factor
Divide dosage are as follows: compounding hyaluronate 0.03-5 parts by weight, polypeptide 2-20 parts by weight, anti-aging plant extracts 4-40 weight
Part.
6. compound anti-apolexis composition according to claim 5, it is characterized in that: dosage of each component in the anti-aging factor are as follows:
Compound hyaluronate 0.6-5 parts by weight, polypeptide 7-20 parts by weight, anti-aging plant extracts 4-40 parts by weight.
7. compound anti-apolexis composition described in any one of -4 according to claim 1, it is characterized in that: further include basic components,
The anti-aging factor is scattered in basic components；The basic components are preferably the mixing of water, glycerol, butanediol and pentanediol
Object.
8. compound anti-apolexis composition the answering in cosmetics of any of claims 1-7 containing plant extracts
With.
9. a kind of cosmetics with anti-aging effects, it is characterized in that: containing plant comprising of any of claims 1-7
The compound anti-apolexis composition of extract, content of the anti-aging factor in cosmetics is preferably 5-30wt%.
10. cosmetics according to claim 9, it is characterized in that: the cosmetics include toner, Essence, lotion, cream
Frost, facial mask.
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| CN116059241A (en) * | 2021-11-04 | 2023-05-05 | 华熙生物科技股份有限公司 | Composition containing hyaluronic acid or salt thereof for improving immunity and promoting gastrointestinal health and application thereof |
| CN115836987A (en) * | 2022-12-23 | 2023-03-24 | 广州市飞科贸易有限公司 | Anti-aging high-permeability hyaluronic acid composition and preparation method thereof |
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