CN115414265A

CN115414265A - Composition and face cream with effects of color correction, skin tendering and moisturizing and preparation method thereof

Info

Publication number: CN115414265A
Application number: CN202211042556.8A
Authority: CN
Inventors: 段东平; 李婷; 任玉枝; 王开利; 张红红; 杜为荣; 赵明; 刘一滨
Original assignee: Huanlian Vision Tianjin Cross Border E Commerce Co ltd; Institute of Process Engineering of CAS
Current assignee: Huanlian Vision Tianjin Cross Border E Commerce Co ltd; Institute of Process Engineering of CAS
Priority date: 2022-08-29
Filing date: 2022-08-29
Publication date: 2022-12-02

Abstract

The invention relates to a composition and a face cream with the effects of color correction, skin tendering and moisture preservation, and a preparation method and application thereof. The strontium-containing compound is creatively added into cosmetic products, and the effects of whitening, resisting inflammation, relieving allergy and repairing skin are achieved by utilizing the strontium-containing compound. The composition related by the invention is creatively compounded by strontium-containing compound, oat peptide, tocopherol, sodium ascorbyl phosphate and hydrolyzed sericin, the raw materials are mutually promoted, the composition has the effects of repairing color, whitening skin, smoothing skin, removing wrinkles, moisturizing and resisting aging, and the components have synergistic promotion effects in different degrees on the effects.

Description

Composition and face cream with effects of color correction, skin tendering and moisturizing and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and relates to a composition with the effects of color correction, skin tendering and moisture preservation, a face cream with the effects of color correction, skin tendering and moisture preservation and a preparation method thereof.

Background

The skin is gradually aged due to the continuous contact with the outside, including external pollution, ultraviolet irradiation and other factors, which continuously generate free radicals. Free radicals are products of human cell metabolism, and excess free radicals have destructive effects on unsaturated fatty acids, protein molecules, nucleic acid molecules, extracellular soluble components, membrane lipids, etc., resulting in wrinkles, sagging, and decreased subcutaneous fat. The free radicals destroy collagen and elastic fiber protein, so as to make skin moisturize and maintain elasticity, and accelerate the precipitation of melanin. The increase in age and certain factors in vitro cause the body and skin tissues to produce free radicals that exceed the body's normal ability to scavenge free radicals, causing damage to the skin tissues and resulting in aging.

Meanwhile, when the environment changes, the skin cuticle cannot timely regulate enough moisturizing factors, the activity of the sebaceous glands is reduced, the grease and water on the face are reduced, the skin is tightened, and fine wrinkles appear under the eyes and beside the canthus. Therefore, when skin is daily protected, the moisture of the skin needs to be kept, and the loss of the moisture of the skin needs to be reduced, so that a certain water-oil balance state of the skin is maintained.

Whitening, moisturizing and antioxidation are important links for maintaining young skin and delaying aging, and the development of a cosmetic product with effective functions of color correction, skin tendering and moisturizing is very significant.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide a composition with the effects of color correction, skin tendering and moisture retention, a facial cream with the effects of color correction, skin tendering and moisture retention and a preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the present invention provides a composition having skin rejuvenation and moisturizing effects, the composition comprising a strontium-containing compound, avenanthramide, tocopherol, sodium ascorbyl phosphate, and hydrolyzed sericin.

Strontium is an indispensable microelement for maintaining the growth of a living body originally in a human body, the strontium plays various biological activities in the human body, the particle size of strontium ions is small, and the strontium ions are easier to permeate into skin compared with organic macromolecules. Firstly, strontium is easier to replace copper ions in tyrosinase participating in melanin synthesis, so that the activity of enzyme is reduced, and the generation of melanin is reduced; secondly, strontium serves as a heat stabilizer in the catalysis process of the collagen enzyme and plays an important role in the processes of collagen metabolism and various rapid reconstitution; thirdly, the strontium has the functions of inducing angiogenesis and promoting cell endothelial proliferation, thereby having the function of repairing skin; in addition, strontium can relieve skin allergy by participating in regulation and control of neurotransmission and muscle contraction, and has an obvious inhibition effect on TNF-alpha (tumor necrosis factor alpha). Strontium enters human body through skin and also has the function of supplementing trace elements.

The composition related by the invention is creatively compounded by strontium-containing compound, oat peptide, tocopherol, sodium ascorbyl phosphate and hydrolyzed sericin, the raw materials are mutually promoted, the composition has the effects of repairing color, whitening skin, smoothing skin, removing wrinkles, moisturizing and resisting aging, and the components have synergistic promotion effects in different degrees on the effects.

The oat peptide can form a layer of thin protective film on the skin, tighten and soften fine wrinkles, lock skin moisture, enable the skin to have smooth silk-like touch and prevent skin aging; has effects in inhibiting MMP-1 activity, and increasing collagen content in skin; can effectively block chain reaction with great harm to skin, thereby maintaining skin structure integrity, maintaining skin elasticity, inhibiting skin thinning and elasticity decrease, and is very similar to cell growth factor (such as EGF), and can accelerate cell proliferation, promote skin metabolism, activate skin, reduce skin roughness, and resist free radicals. Because the oat peptide is a natural polypeptide, the content of carboxyl and amino groups is high, and the sites capable of chelating metal are more, when the oat peptide is chelated with strontium ions, the inhibition activity of the oat peptide on MMP-1 is obviously enhanced, the MMP-1 (matrix metalloproteinase) belongs to zinc-dependent endopeptidase, and the existence of the strontium ions plays a role in replacing zinc ions to a certain extent to destroy the MMP-1 structure. Thus, when strontium is used in combination with avenanthramides, the efficacy of avenanthramides is enhanced.

Wherein, the tocopherol can clear free radicals, resist oxidation, effectively prevent ultraviolet rays from damaging skin, stabilize the protein active structure of cell membranes, keep skin elasticity, promote skin metabolism and further lighten wrinkles and color spots. Wherein, after being absorbed by skin, the vitamin C sodium phosphate can effectively resist the invasion of ultraviolet rays, capture oxygen free radicals and promote the generation of collagen, thereby having the functions of removing wrinkles and resisting aging; it also has tyrosinase inhibiting activity, and can be used for preventing and treating pigmentation and removing various skin stains. Tocopherol is lipophilic, the main site of action is the lipid membrane of the cell, while sodium ascorbyl phosphate is hydrophilic, so it acts mainly in the aqueous cellular fluids and the extracellular space, which, when used in combination, potentiate the above-mentioned effects. In addition, tocopherol is a coenzyme and has an important role in the enzymatic reaction process, and strontium ions are divalent metal ions and are activators of the enzymatic reaction, so that the strontium ions can further enhance the enzymatic reaction of the tocopherol and the effect is further enhanced.

Wherein the hydrolyzed sericin has water-retaining property, antioxidant activity, tyrosinase inhibitory action, etc.

Preferably, the composition with the effects of color correction, skin tendering and moisture retention comprises 1-10 parts of strontium-containing compound, 0.1-2 parts of oat peptide, 0.1-2 parts of tocopherol, 0.1-2 parts of sodium ascorbyl phosphate and 0.05-1 part of hydrolyzed sericin in parts by weight.

When the composition is combined in the specific mass ratio manner, the effects of color correction, whitening, skin tendering, wrinkle removal, moisture retention and anti-aging are more remarkable.

The weight portion of the strontium-containing compound can be selected from 1 portion, 1.5 portions, 2 portions, 2.5 portions, 3 portions, 3.5 portions, 4 portions, 4.5 portions, 5 portions, 5.5 portions, 6 portions, 6.5 portions, 7 portions, 7.5 portions, 8 portions, 8.5 portions, 9 portions, 9.5 portions, 10 portions and the like.

The weight parts of the oat peptide can be selected from 0.1 part, 0.3 part, 0.5 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts and the like.

The weight portion of the tocopherol can be selected from 0.1 portion, 0.3 portion, 0.5 portion, 0.6 portion, 0.8 portion, 1 portion, 1.2 portion, 1.5 portion, 1.8 portion, 2 portions and the like.

The weight parts of the vitamin C sodium phosphate can be 0.1 part, 0.3 part, 0.5 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts and the like.

The weight parts of the hydrolyzed sericin can be selected from 0.05 part, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part and the like.

Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.

In the present invention, the strontium-containing compound includes any one of strontium chloride, strontium chloride hexahydrate, strontium hydroxide, strontium citrate, strontium gluconate, strontium sulfate, strontium carbonate, strontium glutamate, strontium aspartate, strontium ascorbate, strontium malonate, strontium maleate, strontium pyruvate, strontium α -ketoglutarate, or strontium succinate, or a combination of at least two thereof.

Preferably, the composition with the effects of color correction, skin tendering and moisturizing further comprises niacinamide.

The most important effect of niacinamide in the aspect of skin anti-aging is to reduce and prevent dullness, yellowing and vegetable color of skin generated in the early aging process; can also repair the damaged stratum corneum lipid barrier and improve the skin resistance; in addition, the deep water locking effect is achieved; topical niacinamide reduces the production of fatty acids and triglycerides in sebum, thereby narrowing pores and reducing the severity of acne when it occurs. The invention also creatively discovers that the addition of the nicotinamide to the composition can synergistically promote the whitening and moisturizing effects of the composition.

Preferably, the composition with effects of color correction, skin rejuvenation and moisture retention further comprises 1-5 parts by weight of nicotinamide, such as 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts and the like, and other specific points in the numerical range can be selected, and are not repeated herein.

When the nicotinamide and each component in the composition are combined according to the specific mass ratio, the synergistic promotion effect is more remarkable.

In a second aspect, the present invention provides a use of the composition according to the first aspect for skin toning, skin rejuvenation and moisturizing.

Preferably, the cosmetic comprises a cream, essence, lotion, mask, lotion or face cream.

Preferably, the composition with the effects of color correction, skin tendering and moisture retention is 5-30% by mass in the cosmetic, for example, 5%, 8%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30% and the like, and other specific points in the numerical range can be selected, and are not repeated herein.

In a third aspect, the invention provides a cream with effects of color correction, skin tendering and moisture retention, which comprises the composition with effects of color correction, skin tendering and moisture retention, a moisture retention agent, an emollient, a thickening agent, an emulsifier, a penetrating agent and water.

Preferably, the cream with the effects of color correction, skin tendering and moisturizing further comprises any one or a combination of at least two of a fragrance, a preservative, a pH regulator or a toner.

Preferably, the humectant is selected from any one or a combination of at least two of glycerol, propylene glycol, hyaluronic acid, sodium hyaluronate, panthenol, sodium pyrrolidone carboxylate, polyglycerol, butylene glycol, dipropylene glycol, sorbitol, polyethylene glycols, luba gum oil, biogum gum, pentanediol, betaine, or trehalose. More preferred is a combination of glycerol, propylene glycol, sodium hyaluronate, panthenol and sodium pyrrolidone carboxylate.

The moisturizer in the cream according to the present invention is more preferably a combination of glycerin, propylene glycol, sodium hyaluronate, panthenol and sodium pyrrolidone carboxylate, because this combination can maximize the moisturizing effect of the product.

Preferably, the hyaluronic acid is a combination of macromolecular hyaluronic acid, medium molecular hyaluronic acid and small molecular hyaluronic acid.

Preferably, the hyaluronate is a combination of macromolecular hyaluronate, medium molecular hyaluronate and small molecular hyaluronate.

The macromolecular hyaluronic acid refers to hyaluronic acid with a molecular weight of more than 5000, the medium molecular hyaluronic acid refers to hyaluronic acid with a molecular weight of 1000-5000, and the small molecular hyaluronic acid refers to hyaluronic acid with a molecular weight of less than 1000.

Wherein the macromolecular hyaluronic acid (salt) can form a layer of breathable film on the surface of skin, so that the skin is smooth and moist, the invasion of external bacteria, dust and ultraviolet rays can be blocked, and the skin is protected from being damaged; the medium-molecular hyaluronic acid (salt) can tighten the skin and keep moisture for a long time; the small molecular hyaluronic acid (salt) can penetrate into dermis, has effects of slightly dilating capillary, increasing blood circulation, improving metabolism, promoting skin nutrition absorption, increasing skin elasticity, and delaying skin aging. And hyaluronic acid can be combined with strontium ions in the strontium-containing compound to react to generate strontium hyaluronate, so that the metal ions strontium can be more stably present in the cream, and other easily crystallized strontium salts are prevented from being formed and separated out.

Preferably, the emollient is selected from any one or a combination of at least two of squalane, meadowfoam seed oil, dimethicone cross-links, shea butter, jojoba seed oil, macadamia nut seed oil, grapeseed oil, olive oil, cetyl palmitate, ethylhexyl palmitate, tocopherol acetate, hydrogenated polyisobutene, triglycerides of C10-18 fatty acids, caprylic/capric triglycerides, cyclohexasiloxane, cyclopentadimethicone, dimethiconol, octyl methicone, dicaprylyl carbonate, isododecane or pentaerythritol tetraisostearate.

The emollients help to keep the skin soft, pliable, smooth, and can remain on the skin surface, providing lubrication within the stratum corneum. Generally, the skin fills the spaces in the skin surface, replacing the lipid lost in the stratum corneum, reducing the scaly skin, and improving the appearance of the skin.

Preferably, the thickener is selected from any one or a combination of at least two of beeswax, cetostearyl alcohol, stearic acid, acrylic acid/C10-30 alkanol acrylate crosspolymer, carbomer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, sodium acrylate/sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate/VP copolymer, polyacrylic acid or acrylamide/ammonium acrylate copolymer.

The thickener can be matched with an emulsifier, so that the cream can not generate the layering and coagulation phenomena of microphase, and can optimally promote the mutual solubility of the oil phase and the water phase in a macroscopic view, so that the balance is achieved, the viscosity cannot be too high and is not easy to spread, the flowing state is also avoided, the smearing and the absorption of facial skin are not easy, and the stability is better under different environments.

Preferably, the emulsifier is selected from any one or a combination of at least two of monoglyceride stearate, cetostearyl alcohol, polyether modified silicone oil, alkyl glucosides, polyglycerin, sodium stearyl glutamate or hydrogenated lecithin; more preferably a combination of glyceryl monostearate, cetostearyl alcohol and polyether modified silicone oil.

The emulsifier in the cream can not only maintain the stable dispersion of a cream water-oil system, but also enable the cream to be pushed away on the skin more easily, and the combination of monoglyceride stearate, cetostearyl alcohol and polyether modified silicone oil is more preferably used as the emulsifier, so that the system of the product is more stable, and the skin feel is higher.

Preferably, the penetrant comprises any one or a combination of at least two of laurocapram, isosorbide dimethyl ether, or N-alkylbenzisothiazolone. More preferably a combination of laurocapram and isosorbide dimethyl ether.

The penetrant in the facial cream can safely promote penetration, targeted delivery and absorption of active ingredients on skin, and the combination of laurocapram and isosorbide dimethyl ether is more preferably used as the penetrant, so that the penetrant is more favorable for penetration absorption and efficacy exertion of the active ingredients.

In a fourth aspect, the present invention provides a method for preparing a facial cream with effects of color correction, skin tendering and moisturizing according to the third aspect, wherein the preparation method comprises:

(1) Mixing part of emulsifier, part of humectant, part of composition, emollient, thickener, penetrant and water, heating, stirring, and cooling to obtain a first mixture;

mixing the rest emulsifier, the rest humectant, the rest composition and water, heating, stirring and cooling to obtain a second mixture;

(2) And mixing the first mixture and the second mixture, homogenizing, and mixing with the rest raw materials.

Preferably, the heating and stirring of step (1) are independently performed at 60-80 deg.C, such as 60 deg.C, 63 deg.C, 65 deg.C, 68 deg.C, 70 deg.C, 75 deg.C, 78 deg.C, 80 deg.C, etc.

Preferably, the temperature reduction in step (1) is independently to 45-60 ℃, such as 45 ℃, 48 ℃, 50 ℃, 52 ℃, 55 ℃, 57 ℃, 60 ℃ and the like.

Preferably, the mixing with the remaining preparation materials in step (2) is performed at 35-50 deg.C, such as 35 deg.C, 38 deg.C, 40 deg.C, 42 deg.C, 45 deg.C, 47 deg.C, 50 deg.C, etc.

Other specific values within the above range can be selected, and are not further described herein.

Compared with the prior art, the invention has the following beneficial effects:

the strontium-containing compound is creatively added into cosmetic products, and the effects of whitening, resisting inflammation, relieving allergy and repairing skin are exerted by the strontium-containing compound. The composition related by the invention is creatively compounded by strontium-containing compound, oat peptide, tocopherol, sodium ascorbyl phosphate and hydrolyzed sericin, the raw materials are mutually promoted, the composition has the effects of repairing color, whitening skin, smoothing skin, removing wrinkles, moisturizing and resisting aging, and the components have synergistic promotion effects in different degrees on the effects.

Detailed Description

In order to further illustrate the technical means and effects of the present invention, the technical solutions of the present invention are further described below with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

Some of the raw material source information related to the following examples and comparative examples is as follows:

monoglyceride stearate is a product available from lonone international trade limited, guangzhou, model number Lonzest MSA;

cetostearyl alcohol was purchased from maple new materials, inc, model 1220120903, guangzhou;

the white Poissa SEED OIL is obtained from New materials of Haimaichi (Shanghai) with a model of FANCOR MEADODOWFOWFOAM SEED OIL;

the Tocopherol is a DL-alpha-Tocopherol product from Disemann Nutrition products, inc.;

the polydimethylsiloxane is a product which is purchased from Guangzhou Fengsen New materials Co., ltd and has the model number of PMX-200;

the polydimethylsiloxane cross-linked material is a product which is purchased from Zhi Ji (Shanghai) chemical industry Co., ltd and has the model number of CRUSCHEM CRUSIL SEB-3020;

the sodium hyaluronate is a mixture of 40% of macromolecular sodium hyaluronate (Kaixiao biological products Limited, shanghai city), 20% of medium molecular sodium hyaluronate (Zhengzhou Ming Rui chemical products Limited), and 40% of small molecular sodium hyaluronate (Xianqiano biological science and technology Limited);

the oat peptide is a product purchased from Taiai peptide bioengineering technology of Liaoning;

the hydrolyzed sericin is a product purchased from Zhengzhou space control Biotechnology Limited;

the polyether modified silicone oil is a product which is purchased from Zhi-Meo (Shanghai) chemical industry Co.Ltd and has the model of DOW CORNING TI-2011;

the preservative is a mixture of dianthin alcohol 68 and dianthin ketone in a mass ratio of 1.

Other materials were purchased from commercial sources.

Example 1

The embodiment provides a composition with effects of color correction, skin tendering and moisture preservation, which consists of 6 parts of strontium chloride hexahydrate, 0.5 part of oat peptide, 0.5 part of tocopherol, 0.5 part of sodium ascorbyl phosphate and 0.2 part of hydrolyzed sericin in parts by weight.

Example 2

The embodiment provides a composition with effects of color correction, skin tendering and moisture retention, which comprises 10 parts of strontium chloride hexahydrate, 2 parts of avenantenin, 2 parts of tocopherol, 2 parts of sodium ascorbyl phosphate and 1 part of hydrolyzed sericin in parts by weight.

Example 3

The embodiment provides a composition with the effects of color correction, skin tendering and moisture retention, which consists of 1 part by weight of strontium chloride hexahydrate, 0.1 part by weight of avenanthramide, 0.1 part by weight of tocopherol, 0.1 part by weight of sodium ascorbyl phosphate and 0.05 part by weight of hydrolyzed sericin.

Example 4

The embodiment provides a composition with effects of color correction, skin tendering and moisture preservation, which consists of 0.5 part of oat peptide, 3.5 parts of tocopherol, 3.5 parts of sodium ascorbyl phosphate and 0.2 part of hydrolyzed sericin in parts by weight.

Example 5

The embodiment provides a composition with effects of color correction, skin tendering and moisture preservation, which consists of 6 parts of strontium chloride hexahydrate, 0.5 part of oat peptide, 1 part of tocopherol and 0.2 part of hydrolyzed sericin in parts by weight.

Example 6

The embodiment provides a composition with effects of color correction, skin tendering and moisture retention, which comprises 6 parts by weight of strontium chloride hexahydrate, 0.5 part by weight of avenanthramide, 1 part by weight of sodium ascorbyl phosphate and 0.2 part by weight of hydrolyzed sericin.

Example 7

The embodiment provides a composition with effects of color correction, skin tendering and moisture preservation, which comprises, by weight, 5 parts of avenin, 0.5 part of tocopherol, 0.5 part of sodium ascorbyl phosphate and 1.7 parts of hydrolyzed sericin.

Example 8

The embodiment provides a composition with effects of color correction, skin tendering and moisture preservation, which consists of 6 parts of strontium chloride hexahydrate, 0.5 part of tocopherol, 0.5 part of sodium ascorbyl phosphate and 0.7 part of hydrolyzed sericin in parts by weight.

Example 9

The embodiment provides a composition with the effects of color correction, skin tendering and moisture retention, which comprises 6 parts of strontium chloride hexahydrate, 0.7 part of oat peptide, 0.5 part of tocopherol and 0.5 part of sodium ascorbyl phosphate in parts by weight.

Example 10

The embodiment provides a composition with effects of color correction, skin tendering and moisture retention, which is composed of 6 parts of strontium chloride hexahydrate, 1 part of nicotinamide, 0.5 part of oat peptide and 0.2 part of hydrolyzed sericin in parts by weight.

Example 11

The embodiment provides a composition with effects of color correction, skin tendering and moisture retention, which comprises 6 parts by weight of strontium chloride hexahydrate, 0.2 part by weight of tocopherol, 0.2 part by weight of sodium ascorbyl phosphate, 0.6 part by weight of nicotinamide, 0.5 part by weight of oat peptide and 0.2 part by weight of hydrolyzed sericin.

Application example 1

The application example provides a facial cream with the effects of color correction, skin tendering and moisturizing, which comprises the composition of the example 1 with the mass percentage of 7.7%, and the formula table is as follows:

the preparation method comprises the following steps:

(1) Mixing the preparation raw materials of the first component, heating to 70 ℃, uniformly stirring, and cooling to 55 ℃ to obtain a first mixture;

(2) Mixing the preparation raw materials of the second component, heating to 60 ℃, uniformly stirring, and cooling to 55 ℃ to obtain a second mixture;

(3) Mixing the first mixture and the second mixture at 55 deg.C, homogenizing, and mixing with the rest raw materials at 45 deg.C.

Application example 2

The application example provides a facial cream with the effects of color correction, skin tendering and moisturizing, which comprises 8.5% by mass of the composition in the example 2, and the formula table is as follows:

the preparation method comprises the following steps:

(1) Mixing the preparation raw materials of the first component, heating to 80 ℃, uniformly stirring, and cooling to 50 ℃ to obtain a first mixture;

(2) Mixing the preparation raw materials of the second component, heating to 70 ℃, uniformly stirring, and cooling to 50 ℃ to obtain a second mixture;

(3) Mixing the first mixture and the second mixture at 50 deg.C, homogenizing, and mixing with the rest raw materials at 45 deg.C.

Application example 3

The application example provides a facial cream with the effects of color correction, skin tendering and moisturizing, which comprises 5.4% of the composition in the example 3 by mass, and the formula table is as follows:

the preparation method comprises the following steps:

(1) Mixing the preparation raw materials of the first component, heating to 70 ℃, uniformly stirring, and cooling to 50 ℃ to obtain a first mixture;

(2) Mixing the preparation raw materials of the second component, heating to 60 ℃, uniformly stirring, and cooling to 50 ℃ to obtain a second mixture;

Application examples 4 to 11

The present application example provides eight kinds of face creams with effects of color correction, skin tendering and moisturizing, which respectively comprise 7.7% by mass of the compositions of examples 4-11, and the formula table is different from the application example 1 only in that the composition of example 1 is replaced with the compositions of examples 4-11 respectively. Preparation method reference application example 1.

Application example 12

The application example provides a facial cream with the effects of color correction, skin tendering and moisture retention, and the formula of the facial cream is only different from that of the facial cream in application example 1 in that a used penetrating agent does not contain laurocapram, the mass percentage content of isosorbide dimethyl ether is 0.6%, and other components and contents are all kept unchanged. Preparation method reference application example 1.

Application example 13

The application example provides a facial cream with the effects of color correction, skin tendering and moisture retention, and the formula of the facial cream is different from that of the facial cream in the application example 1 only in that a used penetrating agent does not contain isosorbide dimethyl ether, the mass percentage content of laurocapram is 0.6%, and other components and contents are kept unchanged. Preparation method reference application example 1.

Test example 1

Tyrosinase activity inhibition experiments were performed on the compositions prepared in examples 1-11.

Test apparatus and reagents:

the main apparatus is as follows: spectrophotometer SpectronicGENESS-5, thermo corporation, USA.

The main reagents are as follows: tyrosinase powder, enzyme activity 25000U, sigma of USA; l-tyrosine, analytically pure, shanghai JCBIO; ascorbic acid, analytically pure, shanghai national drug.

Solution preparation: weighing 7.8g of sodium dihydrogen phosphate and 17.91g of disodium hydrogen phosphate, dissolving with distilled water to a constant volume of 500mL, and preparing 0.1mol/L phosphate buffer solution with pH of 6.8; accurately measuring 0.431mL of hydrochloric acid with the mass fraction of 36% -38%, and preparing 0.1mol/L hydrochloric acid by using distilled water to fix the volume to 50 mL; weighing 0.05g of L-tyrosine, dissolving in 35mL of 0.1mol/L hydrochloric acid, and then adding 65mL of PBS buffer solution with the pH value of 6.8 to obtain an L-tyrosine solution with the mass fraction of 0.05%; dissolving tyrosinase with enzyme activity of 25000U in 250mL of pure water to prepare a tyrosinase solution with enzyme activity of 100U/mL, subpackaging 1.5mL of EP tubes, and storing 1mL of each in a refrigerator at the temperature of-40 ℃; each sample was diluted with PBS buffer to a mass fraction concentration of 10%.

The specific method comprises the following steps: the sample adding system for each group of tests is shown in the following table, and the PBS buffer solution, the L-tyrosine solution and each sample solution are mixed and put into a constant-temperature water bath kettle at 37 ℃ for water bath for 10-15min; adding tyrosinase into the reaction solution, shaking up, accurately timing, and stopping the reaction for 15min; the plates were sequentially spotted on a 96-well plate, and the absorbance thereof was measured with a microplate reader and the inhibition rate was calculated.

Reagent	C1/mL	C2/mL	S1/mL	S2/mL
					PBS	4	5	2	3
Sample solution	0	0	2	2
					L-tyrosine solution	2	2	2	2
Tyrosinase solution	1	0	1	0

The formula for tyrosinase inhibition is shown below:

tyrosinase inhibition = [ (A1-A2) - (A3-A4) ]/(A1-A2) × 100%

In the formula, A1, A2, A3 and A4 are absorbance values of C1, C2, S1 and S2 respectively.

The test results are shown in table 1:

TABLE 1

Group of	Tyrosinase inhibition rate
		Example 1	91.7％
Example 2	90.2％
		Example 3	90.5％
Example 4	82.3％
		Example 5	87.6％
Example 6	88.1％
		Example 7	77.4％
Example 8	92.3％
		Example 9	85.9％
Example 10	90.8％
		Example 11	93.0％

From the data in table 1: the composition has a remarkable tyrosinase activity inhibiting effect, strontium chloride hexahydrate can promote the exertion of the effects of tocopherol and vitamin C sodium phosphate on the tyrosinase inhibition effect, the tocopherol and the vitamin C sodium phosphate have a synergistic effect on the tyrosinase inhibition effect, and in addition, the addition of nicotinamide can further improve the tyrosinase inhibition effect of the composition.

Test example 2

The DPPH radical scavenging test was performed on the compositions prepared in examples 1-11.

Experimental apparatus and reagents:

the main apparatus is as follows: spectrophotometer SpectronicGENESSYS-5, thermo corporation, USA.

The main reagents are as follows: DPPH, analytically pure, tianjin majo; methanol, analytically pure, tianjin Daoluo; ascorbic acid, analytically pure, shanghai national drug.

Solution preparation: firstly, 1mg of DPPH is dissolved in about 20mL of methanol, ultrasonic treatment is carried out for 5min, and the mixture is fully shaken to ensure that the upper part and the lower part are uniform. Taking 1mL of the DPPH solution, and measuring the A value at 519nm to ensure that A = 1.2-1.3; preparing each sample solution: the compositions of examples 1 to 9 were diluted with methanol to prepare a composition having a mass fraction of 1%.

The specific method comprises the following steps: each set of sample adding system is shown in the following table, the reaction solution is shaken up and placed in a water bath at 37 ℃ for heating for 15min, and then taken out, and an ultraviolet-visible spectrophotometer is used for measuring the absorbance value of the solution.

Reagent	C1/mL	C2/mL	C3/mL
				DPPH solution	2	2	0
Sample solution	0	2	2
				Anhydrous methanol	2	0	2

The formula for calculation of DPPH free radical scavenging rate is shown as follows:

DPPH radical clearance =1- (A2-A3)/A1 × 100%

In the formula, A1, A2 and A3 are absorbance values of C1, C2 and C3 respectively.

The test results are shown in table 2:

TABLE 2

Group of	DPPH radical clearance rate
		Example 1	88.6％
Example 2	85.9％
		Example 3	87.3％
Example 4	90.2％
		Example 5	85.8％
Example 6	84.6％
		Example 7	91.5％
Example 8	82.7％
		Example 9	84.4％
Example 10	78.3％
		Example 11	86.8％

From the data in table 2 it can be seen that: the composition has a remarkable DPPH free radical scavenging effect, the tocopherol and the sodium ascorbyl phosphate have a synergistic effect on the DPPH free radical scavenging effect, and meanwhile, the oat peptide and the hydrolyzed sericin also have a synergistic effect on the DPPH free radical scavenging effect.

Test example 3

VISIA skin analysis evaluation test was performed on the face creams prepared in application examples 1 to 13.

The VISIA skin image analyzer adopts a multi-spectral image technology, can shoot from three angles of a front side, a left side and a right side through a 1200 ten thousand pixel camera, and forms images in three light sources of standard white light, cross-section polarized light and ultraviolet light for three times, so that the VISIA facial image analysis system can systematically analyze pigment spots, textures, pores, wrinkles, ultraviolet light spots, stable spots, red areas and purple on the facial skin of a subject, and provides accurate and quantitative analysis basis for the skin. The change condition of the skin property is observed by recording pigment spots, wrinkles and textures of the face of a subject before and after the test, wherein the absolute value of the value represents the area and the strength of the detected value of the skin characteristic, so that the data obtained by the absolute value (the average value of the test results of the front side, the left side and the right side) is selected as an analysis standard and a data statistical basis. All data of each subject are input into a computer, the measured results are compared, and the skin characteristics and various index data of the subjects are analyzed through statistical treatment. The test apparatus used for the experiment was the VISIA facial image analysis system (canfeld technologies, usa).

The test method specifically comprises the following steps:

110 women with aging skin of 30-40 years old were selected and randomly divided into 11 groups of 10 persons, and the face creams prepared in application examples 1-11 were used respectively. The subjects were continuously applied 2 times a day, 2 morning and night, on a continuous trial for 28 days, and asked for a return visit before (D0) and on day 28 (D28). The test of the same subject is performed by the same measuring person.

Any product (cosmetics or external medicines or internal health care products) cannot be used 15 days before the tested part. After the face is thoroughly cleaned by using a uniform facial cleaning product, the face is lightly wiped by using a paper towel, the face of a tester is photographed by using a VISIA facial image analyzer after the room temperature is 22 +/-2 ℃ and the relative humidity is 40 +/-2% for 15 minutes, and the analysis area is prevented from being interfered by a light reflecting area and hair as much as possible. The face (including the front, the left side and the right side) of the subject was photographed, the obtained absolute scores were subjected to data statistics, the detection data of the pigmented spots and wrinkles of the face of the subject was recorded, and the rate of decrease of D28 with respect to D0 was calculated. The test results are shown in table 3.

TABLE 3

As can be seen from the data in Table 3: the cream has remarkable whitening and spot-fading effects, strontium chloride hexahydrate can promote the exertion of tocopherol and sodium ascorbyl phosphate on the whitening and spot-fading effects, the tocopherol and the sodium ascorbyl phosphate have a synergistic effect on the whitening and spot-fading effects, and in addition, the addition of nicotinamide can further improve the whitening and spot-fading effects of the composition. Meanwhile, the selection of the penetration enhancer can also influence the exertion of the efficacy.

The composition has an obvious wrinkle-removing effect, the tocopherol and the sodium ascorbyl phosphate have a synergistic effect on the wrinkle-removing effect, and the oat peptide and the hydrolyzed sericin also have a synergistic effect on the wrinkle-removing effect. And the selection of the penetration enhancer may also influence the performance of the efficacy.

Test example 4

Moisturizing effect tests were performed on the creams prepared in application examples 1 to 13.

The test was carried out using the world recognized CORNEOMETER capacitance method, the results of which are expressed by set humidity measurements (MMV).

Testing an instrument: skin moisture Corneometer test probe manufactured by Courage + Khazaka, germany (CK, germany).

The test method comprises the following steps: selecting 110 volunteers aged 18-45 years, randomly dividing into 11 groups (5 males and 5 females in each group), and respectively receiving the products of application examples 1-11 for trial. Any product (cosmetics, external medicines or internal health care products) cannot be used 2-3 days before the test of the tested part. Before the test, the testee needs to clean the inner sides of the forearms of both hands uniformly, and the cleaning method is to wipe the forearms clean by using dry facial tissues. The inner sides of the forearms of the two hands of the testee are marked with measurement areas, the area of each test area is 5cm x 5cm, the same arm can simultaneously mark a plurality of areas, and the interval between every two test areas is 2cm.

Before formal test, the people need to sit in a constant temperature and humidity room with the temperature of 20-22 ℃ and the humidity of 40-60% for 30min, and can not drink water and beverage. The forearm was exposed and left in the test condition, and left relaxed.

During the test, a Corneometer is used for measuring blank values of the tested part, and 5 points are fixedly measured in each area according to a certain sequence to obtain an average value. The specialist then takes care of applying the sample and starts timing. And respectively measuring the change of the MMV value at each time according to the experimental design, subtracting a blank value from the average value detected each time to obtain the change of the MMV value in the time period, and removing the blank value to obtain the increase rate of the MMV value.

The skin moisture content increase rate calculation formula is as follows:

skin moisture content increase rate% = (MMV) _t -MMV ₀ )/MMV ₀ ×100％

In the formula: MMV ₀ - - -skin MMV before application

MMV _t - - -skin MMV t period after application

The results are shown in Table 4:

TABLE 4

Group of	Skin moisture content increase rate at 2h
		Application example 1	27.6％
Application example 2	32.8％
		Application example 3	21.2％
Application example 4	22.3％
		Application example 5	25.4％
Application example 6	26.3％
		Application example 7	33.6％
Application example 8	23.8％
		Application example 9	21.3％
Application example 10	28.7％
		Application example 11	27.4％
Application example 12	23.4％
		Application example 13	25.6％

From the data in table 4, it can be seen that: the facial cream has a remarkable moisturizing effect, the oat peptide and the hydrolyzed sericin have a synergistic effect on the moisturizing effect, and meanwhile, the selection of the penetration enhancer can influence the exertion of the effect.

Test example 5

Safety performance evaluation was performed on the creams prepared in application examples 1 to 13:

selecting 110 social volunteers meeting the requirements, wherein the social volunteers are 20-45 years old and randomly divided into 11 groups, and 5 females and 5 males in each group, respectively testing the face cream prepared in application examples 1-11 according to the groups, putting the face cream into a spot tester chamber, and carrying out no treatment on the comparison holes. The patch test device with the test substance is applied to the inner side of forearm of the subject with hypoallergenic tape, and is applied to the skin by pressing gently with palm for 24h. Skin reactions were observed at 30min (after disappearance of the indentation), 24h and 48h after removal of the plaque from the test article, respectively, according to the criteria of table 5.

TABLE 5

The results show that: the application examples 1 to 11 of the invention are all negative reactions, which show that the cream related to the invention is safe and mild and does not produce adverse reactions such as skin irritation, sensitization and the like.

The applicant states that the present invention is illustrated by the above examples, but the present invention is not limited to the above examples, i.e., it is not meant to be construed as being limited to the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.

It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.

Claims

1. A composition with effects of color correction, skin rejuvenation and moisture retention, wherein the composition with effects of color correction, skin rejuvenation and moisture retention comprises a strontium containing compound, avenin, tocopherol, sodium ascorbyl phosphate and hydrolyzed sericin.

2. The composition with the effects of color correction, skin rejuvenation and moisture retention as claimed in claim 1, wherein the composition with the effects of color correction, skin rejuvenation and moisture retention comprises 1-10 parts by weight of strontium-containing compound, 0.1-2 parts by weight of oat peptide, 0.1-2 parts by weight of tocopherol, 0.1-2 parts by weight of sodium ascorbyl phosphate and 0.05-1 part by weight of hydrolyzed sericin.

3. The composition with skin-toning, skin-tendering and moisturizing effects as claimed in claim 1 or 2, wherein the strontium-containing compound comprises any one of strontium chloride, strontium chloride hexahydrate, strontium hydroxide, strontium citrate, strontium gluconate, strontium sulfate, strontium carbonate, strontium glutamate, strontium aspartate, strontium ascorbate, strontium malonate, strontium maleate, strontium pyruvate, strontium alpha-ketoglutarate or strontium succinate or a combination of at least two thereof;

preferably, the composition with effects of color correction, skin tendering and moisturizing further comprises niacinamide;

preferably, the composition with the effects of color correction, skin rejuvenation and moisture retention further comprises 1-5 parts by weight of nicotinamide.

4. Use of a composition having skin lightening, moisturizing effects according to any one of claims 1 to 3 for the preparation of a cosmetic;

preferably, the cosmetic comprises a cream, essence, lotion, mask, lotion or face cream;

preferably, the composition with the effects of color correction, skin tendering and moisture retention is 5-30% of the cosmetic by mass percent.

5. A cream with effects of color correction, skin tendering and moisture retention, which is characterized by comprising the composition with effects of color correction, skin tendering and moisture retention, a humectant, an emollient, a thickener, an emulsifier, a penetrant and water according to any one of claims 1-3.

6. The cream with effects of color correction, skin rejuvenation and moisture retention as claimed in claim 5, wherein the cream with effects of color correction, skin rejuvenation and moisture retention further comprises any one or a combination of at least two of an aromatic, a preservative, a pH regulator or a toning agent.

7. The cream with effects of color correction, skin rejuvenation and moisture retention as claimed in claim 5, wherein the moisture retention agent is selected from any one or a combination of at least two of glycerol, propylene glycol, hyaluronic acid, sodium hyaluronate, panthenol, sodium pyrrolidone carboxylate, polyglycerol, butylene glycol, dipropylene glycol, sorbitol, polyethylene glycols, luba gum oil, biosugar gum, pentanediol, betaine or trehalose; preferably a combination of glycerol, propylene glycol, sodium hyaluronate, panthenol and sodium pyrrolidone carboxylate;

preferably, the hyaluronic acid is a combination of macromolecular hyaluronic acid, medium molecular hyaluronic acid and small molecular hyaluronic acid;

preferably, the hyaluronate is a combination of a macromolecular hyaluronate, a medium molecular hyaluronate and a small molecular hyaluronate;

8. The cream with skin toning, skin rejuvenating and moisturizing effects as claimed in any one of claims 5 to 7, wherein the thickening agent is selected from any one of or a combination of at least two of beeswax, cetearyl alcohol, stearic acid, acrylic acid/C10-30 alkanol acrylate crosspolymer, carbomer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, sodium acrylate/sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate/VP copolymer, polyacrylic acid or acrylamide/ammonium acrylate copolymer;

preferably, the emulsifier is selected from any one of or a combination of at least two of monoglyceride stearate, cetostearyl alcohol, polyether modified silicone oil, alkyl glucosides, polyglycerols, sodium stearyl glutamate or hydrogenated lecithin; preferably a combination of glyceryl monostearate, cetostearyl alcohol and polyether modified silicone oil;

preferably, the penetrant comprises any one or a combination of at least two of laurocapram, isosorbide dimethyl ether or N-N-alkylbenzisothiazolone; a combination of laurocapram and isosorbide dimethyl ether is preferred.

9. The preparation method of the face cream with the effects of color correction, skin tendering and moisture retention according to any one of claims 5-8, characterized by comprising the following steps:

mixing the rest of the emulsifier, the rest of the humectant, the rest of the composition and water, heating, stirring and cooling to obtain a second mixture;

10. The method for preparing a facial cream with the effects of color correction, skin tendering and moisture retention as claimed in claim 9, wherein the heating and stirring of step (1) are independently carried out at 60-80 ℃;

preferably, the temperature reduction of step (1) is independently to 45-60 ℃;

preferably, the mixing with the remaining preparation raw materials in step (2) is carried out at 35-50 ℃.