CN109330911A - A kind of composition and its application containing multi-vitamins and hyaluronate - Google Patents
A kind of composition and its application containing multi-vitamins and hyaluronate Download PDFInfo
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- CN109330911A CN109330911A CN201811382412.0A CN201811382412A CN109330911A CN 109330911 A CN109330911 A CN 109330911A CN 201811382412 A CN201811382412 A CN 201811382412A CN 109330911 A CN109330911 A CN 109330911A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of composition containing multi-vitamins and hyaluronate and its application, effective component is made of compounding hyaluronate, small-molecular peptides and vitamin.The present composition includes the hyaluronate, small-molecular peptides ingredient and vitamin of 3 kinds of molecular weight simultaneously, three can concur under the effect of the skin physiologies such as aquation, barrier function, oxidation and inflammation, coordinate synergy, reaches good anti-aging effects.In addition, present composition ingredient it is simple, can be than more comprehensively providing skin anti-aging effects, and can be synergistic, highly-safe between active constituent.
Description
Technical field
The present invention relates to a kind of composition, especially a kind of composition containing multi-vitamins and hyaluronate and its answer
With belonging to cosmetic technical field.
Background technique
Skin aging is a complex process relevant to cutaneous ultrastructure and biochemistry, these variations are endogenous
Aging and extrinsic aging result.UV radiation causes light aging to deepen intrinsic aging process.Factor, the disease of life style
All have an impact with gravity to skin aging.Intrinsic aging be with age and occur ageing process, by each
The inherent cause of people influences.Exogenous aging is primarily referred to as the influence of environmental factor, as active oxygen (ROS), UV irradiate, freely
Base, these factors have summation to skin and collagen and cellular matrix are caused to be degraded.Two kinds of agings all can in skin level and
It is showed on cellular level.
Dupont etc. summarize skin aging epidermis, the performance of dermoepidermal border (DEJ) and corium, agine mechaism,
The approach of comprehensive anti-aging.From the aquation of epidermis, barrier function, oxidation, DNA damage and reparation, energy production,
Oxygenation, immunity, pigmentation, keratinization effect, to the skin aging of dermoepidermal border, then arrive skin corium
Inflammation, microcirculation etc. can all bring the aging of skin.
In the prior art, there is the relevant report of more anti-aging product, such as patent CN201710942352.2 is disclosed
A kind of Sodium Hyaluronate mixture and application thereof, the hyaluronic acid which mentions different molecular weight compounding can have anti-ageing
Old effect.The main mechanism of action of the product of the patent is played comprehensively by the Sodium Hyaluronate mixture of different molecular weight
The effect of moisturizing, and skin moisturizing is a link of anti-aging, cannot play the role of anti-aging comprehensively.Patent
201711499087.1 disclose a kind of kahikatea dew compact eye mask of anti-aging and preparation method thereof, are revealed by butanediol, glycerol, kahikatea
Fungus extract, grape berry extract, chamomile extracting solution, zein amino acids, Abelmoschus esculentus berry extract, biology sugar
Glue, tremella polysaccharides, panthenol, oligopeptides -1, Sodium Hyaluronate, allantoin etc. composition, the product rely primarily on kahikatea dew fungus extract,
Crease-resistant, moisturizing, anti-is played in the substances collocation such as grape berry extract, chamomile extracting solution and Abelmoschus esculentus berry extract, oligopeptides -1
The effect of the multi-faceted maintenance skin of many aspects such as oxidation, antiviral, the promotion cell proliferation differentiation of anti-inflammatory, but main active
High expensive, kahikatea especially therein reveals fungus extract scarcity of resources, at high cost.Patent 201410582635.7 discloses one
The Essence of kind energy activating skin vigor and anti-aging, is extracted by collagen, ceramide, people's oligopeptides -1, golden yellow chamomile
The composition such as object, snail pituitary extract, glucan, hyaluronic acid, tocopherol, vitamin C, the product have enhancing cell comprehensively
Vigor and elasticity increase skin tightness, remove epidermis dimness metabolin, help the works such as impaired organization healing and consolidation skin
With, but rise in being formulated moisturizing, Firm, it is crease-resistant, repair, the active constituent of antiphlogistic antibacterial effect is to work respectively, between not
There is synergy, only mineral water used in it improves the absorption of active constituent.
It can thus be seen that the cosmetics of current anti-aging or be only capable of acting on one or several anti-aging factors,
Anti-aging effects are not particularly evident, or excessive at being grouped as, at high cost, thus find a kind of ingredient origin it is simple extensively,
Can play for interior external source reason can be synergistic, highly-safe between more comprehensive anti-aging effects and active constituent
Anti-aging effects composition is very necessary.
Summary of the invention
Based on above-mentioned deficiency, the present invention provides a kind of composition containing multi-vitamins and hyaluronate, the combination
Object ingredient is simple, from a wealth of sources, can be than more comprehensively providing skin anti-aging effects, and increasing can be cooperateed between active constituent
It imitates, is highly-safe.
Composition of the present invention containing multi-vitamins and hyaluronate includes compounding hyaluronate, small-molecular peptides simultaneously
With three constituents of vitamin, by the collaboration collocation of this three, the aquation that can effectively improve skin, barrier function is applied in combination
The effect of the skin physiologies such as energy, oxidation and inflammation is played more comprehensive anti-aging and is made to reach synergistic effect
With.
Specifically, the present invention provides a kind of composition containing multi-vitamins and hyaluronate, the composition have
Effect ingredient is made of compounding hyaluronate, small-molecular peptides and vitamin.
Further, the compounding hyaluronate refers to that the mixture of hyaluronate, the hyaluronate are
Soluble-salt of hyaluronic acid, including Sodium Hyaluronate, hyaluronic acid magnesium, zinc hyaluronate, potassium hyaluronate etc. are commonly
Hyaluroni, each hyaluronate effect are similar.Preferably, the compounding hyaluronate used in the present invention refers to 3 kinds
The mixture of the hyaluronate A of different molecular weight, hyaluronate B and hyaluronate C, wherein point of hyaluronate A
Son amount is 1000.1kDa-1800kDa, and the molecular weight of hyaluronate B is 10.1kDa-1000kDa, point of hyaluronate C
Son amount is less than or equal to 10kDa.Hyaluronate A can form one layer of protective cover in skin surface, help improve the barrier function of skin
Can, hyaluronate B and C pass through the aquation that fixed hydrone supports skin, improve skin immunity, while hyaluronic acid
Salt C can increase skin elasticity with Transdermal absorption.The hyaluronate of three kinds of different molecular weights is used in compounding, can be simultaneously in skin
Skin surface layer and deep layer play moisture-keeping function, play anti-aging effects.
Preferably, the molecular weight of the hyaluronate A is 1300kDa-1800kDa, the molecular weight of hyaluronate B
For 200kDa-400kDa, the molecular weight of hyaluronate C is 3kDa-10kDa.
Preferably, the hyaluronate C is hydrolysis hyaluronate.
Further, the mass ratio of hyaluronate A, hyaluronate B and hyaluronate C are 0.01-0.5:0.01-
0.5:0.01-4, the more preferably mass ratio of hyaluronate A, hyaluronate B and hyaluronate C are 0.1-0.3:0.1-
0.3:0.5-4.
Further, the small-molecular peptides are the mixture of oligopeptides -1, oligopeptides -2 and oligopeptides -5.Oligopeptides -1 (EGF) can promote
It is quickly repaired into skin part, adjusts fibroblast disorder, while effectively scar being inhibited to be formed；Oligopeptides -2 (IGF) is into fibre
The rush disintegrating agent for tieing up cell and endothelial cell cooperates with cell factors such as oligopeptides -1, oligopeptides -5 and promotes Skin Cell regeneration, rebuilds
Skin barrier；Oligopeptides -5 (KGF) participates in the gene expression of merisis by sophisticated signal transmitting starting epithelial cell, to pierce
Swash the metabolism of epithelial tissue.
Further, oligopeptides -1, oligopeptides -2, oligopeptides -5 mass ratio be 1-10:1-10:1-10, preferably oligopeptides -1, few
Peptide -2, oligopeptides -5 mass ratio be 3-8:2-5:2-5.
Further, the vitamin be vitamin A and its derivative, vitamin B5 and its derivative, vitamin C and its
The mixture of derivative and vitamin E and its derivative.
Preferably, the vitamin A is retinyl palmitate, and the vitamin B5 is panthenol, and the vitamin C is anti-
Bad hematic acid phosphate magnesium, the vitamin E are tocopherol acetate.Retinyl palmitate is a kind of derivative of vitamin A,
It is easy to be absorbed by the skin, is then converted into retinol.The main function of retinol is exactly to accelerate skin metabolism, is promoted thin
Born of the same parents' hyperplasia, while collagen being excited to generate, also there is certain effect for treatment acne, many classical brand and products will
Effective anti-ageing ingredient that the ingredient is recommended as many dermatologists of anti-oxidant anti-ageing preferred ingredient and the U.S..Panthenol
Also known as dexpanthenol is mainly used as moisturizer and skin conditioning agent, is used together with vitamin B6, can increase after skin absorbs
Add hyaluronic acid contents in skin, promote the metabolism of human body protein, fat, carbohydrate, protect skin and mucous membrane, prevents and treats rugula
Line, inflammation, solarization are not glutinous greasy moisturizing ingredients, have potent moistening effect, and close with skin sebum film, are easy to absorb
The cuticula of infiltration and infiltration skin surface keeps skin soft, effectively prevents the coarse phenomenon of skin, reaches skin moisturizing and tissue
The effect of reparation, gives skin gloss.Magnesium ascorbyl phosphate abbreviation MAP, be it is most stable in vitamin C derivatives and most by
One kind of welcome, due to its lipophilicity, it is easy to be absorbed by the skin, be in neutral pH it is stable, it is non-stimulated to skin.
When it passes through epidermis, MAP is converted into ascorbic acid (vitamin C) by dephosphorylation.Tocopherol acetate belongs to dimension life
The derivative of plain E often does antioxidant use in cosmetics, there is good antioxidant effect, it is a kind of oil-soluble day
Right substance is good nutrition moisturizing agent to skin, makes an addition in skin care products, can be avoided the rancid oxidation of grease, stabilizes oil
Rouge, moisturizing and maintain connective tissue and protect skin not by terms of have fine performance, the ingredient energy
Make skin soft-touch and keep skin moisture, wound healing, prevention inflammation is promoted to prevent the coarse chap of skin, improve blackspot,
Security risk index is not high therefore uses extensive.
Further, vitamin A and its derivative: vitamin B5 and its derivative: vitamin C and its derivative: dimension life
The mass ratio of plain E and its derivative is 0.01-0.1:0.01-1:0.01-1:0.01-1, more preferably vitamin A and its derivative
Object: vitamin B5 and its derivative: vitamin C and its derivative: the mass ratio of vitamin E and its derivative is 0.05-0.1:
0.1-1:0.1-1:0.1-1.
Further, each effective ingredient consumption in the composition containing multi-vitamins and hyaluronate are as follows: compounding is transparent
Matter hydrochlorate 0.03-5 parts by weight, small-molecular peptides 3-30 parts by weight, vitamin 0.04-3.1 parts by weight.Preferably, it is given birth to containing compound dimension
Each effective ingredient consumption in the composition of element and hyaluronate are as follows: compounding hyaluronate 0.7-4.6 parts by weight, small-molecular peptides
7-18 parts by weight, vitamin 0.35-3.1 parts by weight.
Further, also contain base in addition to effective component in the composition containing multi-vitamins and hyaluronate
Matter ingredient, so that each effective component can be mixed uniformly, for skin, the matrix includes solvent, emulsifier, preservative etc..
The present invention is compounded hyaluronate, small-molecular peptides and vitamin is compounded, aquation, screen from epidermis
Barrier function, oxidation, DNA damage and reparation, energy production, oxygenation, immunity, pigmentation, cutin are turned into
With to the skin aging of dermoepidermal border, then solving to various aspects such as inflammation, the microcirculations of skin corium the original of skin aging
Cause plays the role of more comprehensive anti-aging.The present invention can be used as anti-containing the composition of multi-vitamins and hyaluronate
Aging component is in cosmetics, for the application of composition of the invention in cosmetics also within protection scope.It is described
Cosmetics may include toner, essence, cream, frost, facial mask, importing liquid etc..
Further, the present invention also provides a kind of cosmetics with anti-aging effects, the cosmetic actives packets
It includes above-mentioned containing multi-vitamins and hyaluronic acid salt composite；Preferably, the compound anti-aging factor the containing in cosmetics
Amount is 5-30wt%.The type of cosmetics is as set forth above, it is possible to be toner, essence, cream, frost, facial mask, importing liquid etc..
The present composition includes the hyaluronate, small-molecular peptides ingredient and vitamin of 3 kinds of molecular weight, San Zheke simultaneously
To be concured under the effect of the skin physiologies such as aquation, barrier function, oxidation and inflammation, coordinates synergy, reach
Good anti-aging effects.In addition, composition components of the present invention containing multi-vitamins and hyaluronic acid are simple, it is complete to compare
The offer skin anti-aging effects in face, and can be synergistic, highly-safe between active constituent.
Specific embodiment
Technical solution and advantage in order to better illustrate the present invention, below in conjunction with specific embodiment to the present invention
It is described further.It should be noted that the unspecified technological parameter of the present invention, raw material etc. are according to ability
Domain conventional technical means carries out.
The present invention provides a kind of composition containing multi-vitamins and hyaluronic acid, effective component is by compounding hyalomitome
Hydrochlorate, small-molecular peptides and vitamin composition.Wherein, compounding hyaluronate be 3 kinds of different molecular weights hyaluronate A, thoroughly
The mixture of bright matter hydrochlorate B and hyaluronate C, small-molecular peptides are the mixture of oligopeptides -1, oligopeptides -2 and oligopeptides -5, vitamin
For vitamin A and its derivative, vitamin B5 and its derivative, vitamin C and its derivative and vitamin E and its derivative
Mixture.
Further, the molecular weight of hyaluronate A is 1000.1kDa-1800kDa, such as 1000.1kDa-
1300kDa, 1300kDa-1500kDa, 1300kDa-1800kDa, 1500kDa-1800kDa, preferably 1300kDa-
1800kDa.The molecular weight of hyaluronate B is 10.1kDa-1000kDa, such as 10.1kDa-100kDa, 100kDa-
200kDa, 200kDa-400kDa, 400kDa-800kDa, 800kDa-1000kDa, preferably 200kDa-400kDa.Hyalomitome
The molecular weight of hydrochlorate C is less than or equal to 10kDa, such as 3kDa-5kDa, 5kDa-10kDa, preferably 3kDa-10kDa.
Further, the mass ratio of hyaluronate A, hyaluronate B and hyaluronate C are 0.01-0.5:0.01-
0.5:0.01-4, preferably 0.1-0.3:0.1-0.3:0.5-4.In the specific embodiment of the invention, hyaluronate A, thoroughly
The mass ratio of bright matter hydrochlorate B and hyaluronate C is 0.01:0.01:0.01,0.01:0.5:4,0.5:0.01:0.01,0.05:
0.05:0.1,0.5:0.5:4,0.1:0.1:4,0.3:0.2:1 or 0.2:0.3:0.5.
Further, oligopeptides -1, oligopeptides -2, oligopeptides -5 mass ratio be 1-10:1-10:1-10, more preferably 3-8:2-
5:2-5.In the specific embodiment of the invention, oligopeptides -1, oligopeptides -2, oligopeptides -5 mass ratio be 1:1:1,1:10:10,10:
1:1,10:10:1,3:2:5,5:5:2,3:2:2,8:3:3 or 3:8:8.
Further, vitamin A and its derivative: vitamin B5 and its derivative: vitamin C and its derivative: dimension life
The mass ratio of plain E and its derivative is 0.01-0.1:0.01-1:0.01-1:0.01-1, more preferably 0.05-0.1:0.1-1:
0.1-1:0.1-1.In the specific embodiment of the invention, vitamin A and its derivative: vitamin B5 and its derivative: dimension life
Plain C and its derivative: the mass ratio of vitamin E and its derivative is 0.01:0.01:0.01:0.01,0.01:1:1:0.01,
0.1:0.01:0.01:1,0.01:1:1:0.01,0.1:0.5:0.5:1,0.05:0.1:0.1:0.5,0.07:1:1:0.4,
0.06:0.4:0.2:0.1 or 0.02:0.05:0.05:0.05.
Further, vitamin A is preferably retinyl palmitate, and vitamin B5 is preferably panthenol, and vitamin C is preferably
Magnesium ascorbyl phosphate, vitamin E are preferably tocopherol acetate.
Further, the dosage relation of hyaluronate, small-molecular peptides and vitamin is compounded are as follows: compounding hyaluronate
0.03-5 parts by weight, small-molecular peptides 3-30 parts by weight, vitamin 0.04-3.1 parts by weight, preferably are as follows: compounding hyaluronate
0.7-4.6 parts by weight, small-molecular peptides 7-18 parts by weight, vitamin 0.35-3.1 parts by weight.In a certain specific embodiment party of the present invention
In formula, 0.03 parts by weight of hyaluronate, 30 parts by weight of small-molecular peptides, 0.04 parts by weight of vitamin are compounded.It is a certain in the present invention
In specific embodiment, 5 parts by weight of hyaluronate, 10 parts by weight of small-molecular peptides, 3.1 parts by weight of vitamin are compounded.In this hair
In bright a certain specific embodiment, 0.3 parts by weight of hyaluronate, 20 parts by weight of small-molecular peptides, 0.4 weight of vitamin are compounded
Part.In a certain specific embodiment of the present invention, 2 parts by weight of hyaluronate, 3 parts by weight of small-molecular peptides, vitamin 3.1 are compounded
Parts by weight.In a certain specific embodiment of the present invention, 4.2 parts by weight of hyaluronate, 14 parts by weight of small-molecular peptides, dimension are compounded
2.1 parts by weight of raw element.In a certain specific embodiment of the present invention, 0.7 parts by weight of hyaluronate, 18 weight of small-molecular peptides are compounded
Measure part, 0.35 parts by weight of vitamin.In a certain specific embodiment of the present invention, 3 parts by weight of hyaluronate, small molecule are compounded
11 parts by weight of peptide, 1 parts by weight of vitamin.In a certain specific embodiment of the present invention, 2 parts by weight of hyaluronate are compounded, it is small
7 parts by weight of molecular peptide, 3.1 parts by weight of vitamin.In a certain specific embodiment of the present invention, 4.6 weight of hyaluronate is compounded
Measure part, 8 parts by weight of small-molecular peptides, 1.5 parts by weight of vitamin.
Further, composition of the present invention containing multi-vitamins and hyaluronate be in addition to effective component, there are also matrix,
The matrix is the matrix, such as emulsifier, solvent, preservative etc. being usually used in cosmetics in the prior art, according to product kind
Class matrix is possible to different.The composition can be made toner, essence, cream, frost, facial mask, import the various products such as liquid, produce
Product preparation method is according to each cosmetics conventional method disclosed in the prior art.
Several preferred embodiments of the invention are set forth below, it is following to be further expalined and to illustrate to the present invention
In embodiment, unless otherwise instructed, each Ingredient Amount is parts by weight.
Embodiment 1
Composition of the present invention containing multi-vitamins and hyaluronate includes the ingredient of following parts by weight: compounding hyalomitome
4.2 parts of sour sodium ingredient (the Sodium Hyaluronate A: the hyalomitome of molecular weight 200kDa-400kDa of molecular weight 1300kDa-1800kDa
The mass ratio of sour sodium B: molecular weight 3kDa-10kDa Sodium Hyaluronate C is 0.1:0.1:4, i.e. molecular weight 1300kDa-
0.1 part of the Sodium Hyaluronate A of 1800kDa, 0.1 part of the Sodium Hyaluronate B of molecular weight 200kDa-400kDa and molecular weight
4 parts of the Sodium Hyaluronate C of 3kDa-10kDa), (oligopeptides -1: oligopeptides -2: the mass ratio of oligopeptides -5 is 14 parts of small-molecular peptides ingredient
8:3:3, i.e. 8 parts of oligopeptides -1,3 parts of oligopeptides -2,3 parts of oligopeptides -5), 2.1 parts of (retinyl palmitates: general of vitamin ingredients
Alcohol: magnesium ascorbyl phosphate: the mass ratio of tocopherol acetate is 0.1:0.5:0.5:1, i.e. retinyl palmitate 0.1
Part, 0.5 part of panthenol, 0.5 part of magnesium ascorbyl phosphate and 1 part of tocopherol acetate).
Embodiment 2
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: compounding hyaluronic acid
Sodium is the Sodium Hyaluronate A of molecular weight 1300kDa-1800kDa of mass ratio 0.3:0.2:1, molecular weight 200kDa-400kDa
The mixture of the Sodium Hyaluronate C of Sodium Hyaluronate B and molecular weight 3kDa-10kDa.
Embodiment 3
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: compounding hyaluronic acid
Sodium is Sodium Hyaluronate A, the molecular weight 200kDa-400kDa of the molecular weight 1300kDa-1800kDa of mass ratio 0.2:0.3:0.5
Sodium Hyaluronate B and molecular weight 3kDa-10kDa Sodium Hyaluronate C mixture.
Embodiment 4
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: small-molecular peptides ingredient
For the mixture of the oligopeptides -1 of mass ratio 3:2:5, oligopeptides -2 and oligopeptides -5.
Embodiment 5
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: small-molecular peptides ingredient
For the mixture of the oligopeptides -1 of mass ratio 5:5:2, oligopeptides -2 and oligopeptides -5.
Embodiment 6
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: small-molecular peptides ingredient
For the mixture of the oligopeptides -1 of mass ratio 3:2:2, oligopeptides -2 and oligopeptides -5.
Embodiment 7
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: vitamin ingredients are
The retinyl palmitate of mass ratio 0.05:0.1:0.1:0.5, panthenol, magnesium ascorbyl phosphate and tocopherol acetate
Mixture.
Embodiment 8
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: vitamin ingredients are
The mixing of the retinyl palmitate, panthenol, magnesium ascorbyl phosphate and tocopherol acetate of mass ratio 0.07:1:1:0.4
Object.
Embodiment 9
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: vitamin ingredients are
The retinyl palmitate of mass ratio 0.06:0.4:0.2:0.1, panthenol, magnesium ascorbyl phosphate and tocopherol acetate
Mixture.
Embodiment 10
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: compounding hyaluronic acid
0.7 parts by weight of sodium, 18 parts by weight of small-molecular peptides, 0.35 parts by weight of vitamin.
Embodiment 11
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: compounding hyaluronic acid
3 parts by weight of sodium, 11 parts by weight of small-molecular peptides, 1 parts by weight of vitamin.
Embodiment 12
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: compounding hyaluronic acid
2 parts of sodium, 7 parts of small-molecular peptides, 3.1 parts of vitamin.
Embodiment 13
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: compounding hyaluronic acid
4.6 parts by weight of sodium, 8 parts by weight of small-molecular peptides, 1.5 parts by weight of vitamin.
Embodiment 14
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: hyaluronate A
Molecular weight be 1000.1kDa-1300kDa, the molecular weight of hyaluronate B is 10.1kDa-200kDa, hyaluronate C's
Molecular weight is 3kDa-10kDa.
Embodiment 15
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: hyaluronate A
Molecular weight be 1000.1kDa-1300kDa, the molecular weight of hyaluronate B is 400kDa-800kDa, hyaluronate C's
Molecular weight is 3kDa-10kDa.
Comparative example 1
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: compounding hyaluronic acid
Sodium is the Sodium Hyaluronate B of 0.1 part of the Sodium Hyaluronate A of molecular weight 1300kDa-1800kDa, molecular weight 200kDa-400kDa
0.1 part of composition.
Comparative example 2
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: compounding hyaluronic acid
Sodium is the Sodium Hyaluronate of 0.1 part of the Sodium Hyaluronate A1 of molecular weight 2000-2500kDa, molecular weight 1000kDa-1500kDa
4 parts of the Sodium Hyaluronate C1 compositions of 0.1 part of B1, molecular weight 9kDa-20kDa.
Comparative example 3
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: small-molecular peptides ingredient
For 8 parts of oligopeptides -2,3 parts of oligopeptides -3,3 parts of oligopeptides -6 compositions.
Comparative example 4
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: small-molecular peptides ingredient
For 8 parts of oligopeptides -29,3 parts of palmitoyl oligopeptide, 3 parts of oligopeptides -6 compositions.
Comparative example 5
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: vitamin ingredients are
0.1 part of retinyl palmitate, 0.5 part of panthenol, 1 part of tocopherol acetate composition.
Comparative example 6
The component of composition containing multi-vitamins and hyaluronate with embodiment 1, unlike: vitamin ingredients are
0.1 part of biotin, 0.5 part of panthenol and 1 part of tocopherol acetate composition.
Application examples
The product of the above embodiment of the present invention and comparative example can be used as anti-aging for making up in cosmetics
Content in product can be 5-30wt%, such as 5wt%, 10wt%, 15wt%, 20wt%, 25wt%, 30wt%.Cosmetics
Type can be toner, essence, cream, frost, facial mask, import liquid etc..In the preparation, in addition to above-described embodiment and comparative example system
Standby product is outside effective component, further includes matrix necessary to various dosage forms are made.Matrix can choose each in the prior art
The conventional substrate of dosage form, cosmetics preparation method are prepared according to prior art conventional method.
In order to verify the excellent effect of the composition of the invention containing multi-vitamins and hyaluronate, by above-described embodiment
Face cream is made with the effective component of comparative example, the method is as follows:
1 face cream basic components of table
Note: the raw material in E phase is separately added into other phases according to water-soluble and oil is molten, and those skilled in the art can be according to reality
It needs to carry out conventional selection
1) A is added to oily phase tank, is heated to 70-75 DEG C, stirred spare to melting completely；
2) C is added to emulsion tank, is warming up to 80-85 DEG C, emulsion tank is added after B phase is uniformly dispersed, with sweet in C phase
Hyaluronate in oil dispersed E phase, then remaining E phase raw material is added in emulsion tank, heat preservation is stirred to being completely dissolved, is obtained
Mixed phase；
3) A is added to mixed phase, homogeneous is opened after mixing 10 minutes, stirred evenly.45 DEG C or less addition D phases are cooled to, are mixed
It closes uniformly, 35 DEG C of dischargings obtain face cream.
The face cream prepared using above application examples, verifies product of the present invention anti-aging effects.
1, free radical scavenging activity is tested
The experiment of 1.1 hydroxyl radical free radical clearance rates
Method: taking the ethanol solution that 1.0mL concentration is the Phen of 1.865mmol/L in test tube with ground stopper, point
Not Jia Ru concentration be 0.2mol/L pH 7.4 phosphate buffer 2mL and 1mL 1-15 containing embodiment or comparative example 1-6 group
The FeSO that 1.0mL concentration is 1.865mmol/L is added in the face cream for closing object after mixing well4·7H2O solution adds after mixing again
Enter the H of 1.0mL 0.03% (v/v)2O2, after 37 DEG C of waters bath with thermostatic control, 60min, measure each group mixed solution respectively at 536nm
Absorbance value, obtain A1, using distilled water replace composition as blank group survey absorbance value, obtain A2, with distilled water substitution H2O2Make
For damage group, surveying its absorbance value is A3, and the clearance rate of the hydroxyl radical free radical of sample calculates as follows: hydroxyl radical free radical is clear
Except rate (%)=[(A1-A3)/(A2-A3)] × 100%, the average value measured three times is taken, testing result is as shown in table 1.
The experiment of 1.2DPPH free radical scavenging activity
Method: it takes the DPPH- absolute methanol solution that concentration is 3mL 0.0178mmol/L in cuvette, adds 3mL
The face cream of the composition of 1-15 containing embodiment or comparative example 1-6 mixes and surveys light absorption value at 517nm wavelength immediately, light absorption value note
For A1, then light absorption value is surveyed after 30min is kept in dark place at 37 DEG C, is denoted as A2, blank control is only plus DPPH- anhydrous methanol is molten
Liquid, light absorption value are denoted as A3.DPPH free radical scavenging activity: DPPH free radical scavenging activity (%)=[1- (A1- is calculated as follows
A2)/A3] × 100%, the average value measured three times is taken, testing result is as shown in table 2.
Table 2
From table 2 it can be seen that the composition containing multi-vitamins and hyaluronate of inventive formulation is with more excellent
Scavenging action to hydroxyl free radical and DPPH free radical scavenging activity, hence it is evident that have better anti-aging effects, additionally by with comparative example
The comparison of 1-6 finds, after changing the hyaluronate molecular weight of the present composition, constituent species, Scavenging action to hydroxyl free radical and
DPPH free radical scavenging activity is significantly lower than composition of the invention.
2, skin elasticity is tested
Test pre-treatment: test population is that average age is to have lossless the wounded of wrinkle, skin health 20 in 40-50 years old,
Male 6, uses the face cream containing 2,4,6 this 5 kinds of compositions of embodiment 1,10 and comparative example respectively by female 14.Subject is averaged
It is divided into 5 groups, every group uses different face creams, and subject smears each test face cream in face, and daily morning and evening spread product is twice, real
It tests effect and carries out self comparison.During experiment, subject cannot smear any other cosmetics in Test sites.Subject is even
Continue using after test face cream 0 week, 1 week, 2 weeks, 3 weeks, 4 weeks, is tested.
Skin elasticity test: using skin elasticity instrument Cutometer MPA580 test respectively the 0th week, 1 week, 2 weeks, 3 weeks,
4 weeks skin conditions, test position are cheekbone portion, and probe is averaged in same tested region duplicate measurements 3 times when measurement.It surveys
Examination parameter is R2, and R2 is closer to 1, elastic better ,-the 0 week R2 value of R2 changing value=4th week R2 value of skin, R2 change rate=
R2 changing value/0th week R2 value.The R2 changing value of each group subject is averaged, R2 average change value is denoted as, each group is tested
The R2 change rate of person is averaged, and is denoted as the R2 average rate of change.
The test result of specific skin elasticity is as shown in table 3:
Table 3
The face cream of the composition preparation of embodiment 1,10 can effectively improve the elasticity of skin it can be seen from upper table 3, say
The bright composition of the invention containing multi-vitamins and hyaluronate can effectively play senile-resistant efficacy；Simultaneously from comparative example
2,4,6 it can analyze and obtain, after constituent species, the hyaluronate molecular weight of composition change, the elasticity of skin is reduced, explanation
Composition of the invention has more preferably anti-aging effects.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of composition containing multi-vitamins and hyaluronate, it is characterized in that: effective component by compounding hyaluronate,
Small-molecular peptides and vitamin composition.
2. the composition according to claim 1 containing multi-vitamins and hyaluronate, it is characterized in that: the compounding is saturating
Bright matter hydrochlorate is the mixture of the hyaluronate A of 3 kinds of different molecular weights, hyaluronate B and hyaluronate C, hyalomitome
The molecular weight of hydrochlorate A is 1000.1kDa-1800kDa, and the molecular weight of hyaluronate B is 10.1kDa -1000kDa, hyalomitome
The molecular weight of hydrochlorate C is less than or equal to 10kDa；Preferably, the molecular weight of the hyaluronate A is 1300kDa-1800kDa,
The molecular weight of hyaluronate B is 200kDa-400kDa, and the molecular weight of hyaluronate C is 3kDa-10kDa；Preferably, institute
The hyaluronate C stated is hydrolysis hyaluronate；Preferably, the hyaluronate includes Sodium Hyaluronate, hyaluronic acid
Magnesium, zinc hyaluronate, potassium hyaluronate, preferably Sodium Hyaluronate.
3. the composition according to claim 2 containing multi-vitamins and hyaluronate, it is characterized in that: hyaluronate
A, the mass ratio of hyaluronate B and hyaluronate C are 0.01-0.5:0.01-0.5:0.01-4, preferably 0.1-0.3:
0.1-0.3:0.5-4.
4. the composition according to claim 1 containing multi-vitamins and hyaluronate, it is characterized in that: the small molecule
Peptide be oligopeptides -1, oligopeptides -2 and oligopeptides -5 mixture, it is preferred that oligopeptides -1, oligopeptides -2, oligopeptides -5 mass ratio be 1-10:
1-10:1-10, more preferably 3-8:2-5:2-5；The vitamin is vitamin A and its derivative, vitamin B5 and its derivative
The mixture of object, vitamin C and its derivative and vitamin E and its derivative, it is preferred that vitamin A and its derivative: dimension life
Plain B5 and its derivative: vitamin C and its derivative: the mass ratio of vitamin E and its derivative is 0.01-0.1:0.01-1:
0.01-1:0.01-1, more preferably 0.05-0.1:0.1-1:0.1-1:0.1-1.
5. the composition according to claim 4 containing multi-vitamins and hyaluronate, it is characterized in that: the vitamin
A is retinyl palmitate, and vitamin B5 is panthenol, and vitamin C is magnesium ascorbyl phosphate, and vitamin E is tocopherol second
Acid esters.
6. the composition according to any one of claims 1-5 containing multi-vitamins and hyaluronate, it is characterized in that:
Each effective ingredient consumption are as follows: compounding hyaluronate 0.03-5 parts by weight, small-molecular peptides 3-30 parts by weight, vitamin 0.04-3.1
Parts by weight.
7. the composition according to claim 6 containing multi-vitamins and hyaluronate, it is characterized in that: each effective component
Dosage are as follows: compounding hyaluronate 0.7-4.6 parts by weight, small-molecular peptides 7-18 parts by weight, vitamin 0.35-3.1 parts by weight.
8. the answering in cosmetics of the composition containing multi-vitamins and hyaluronate of any of claims 1-7
With.
9. a kind of cosmetics with anti-aging effects, it is characterized in that: effective component includes described in any one of claim 1-7
The composition containing multi-vitamins and hyaluronate；Preferably, the combination containing multi-vitamins and hyaluronate
Mass percentage of the object in cosmetics is 5-30%.
10. cosmetics according to claim 9, it is characterized in that: the cosmetics include toner, essence, cream, frost, face
Film imports liquid.
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| CN111012694A (en) * | 2019-12-30 | 2020-04-17 | 华熙生物科技股份有限公司 | Hyaluronic acid-containing spray for repairing and moisturizing soles and preparation method thereof |
| CN111588652A (en) * | 2020-05-14 | 2020-08-28 | 华熙生物科技股份有限公司 | Composition containing hyaluronic acid and polyalcohol and application thereof |
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| CN110151593A (en) * | 2019-05-27 | 2019-08-23 | 广州瑞诗生物科技有限公司 | A kind of hyaluronic acid skin care compositions |
| CN110974830A (en) * | 2019-12-26 | 2020-04-10 | 华熙生物科技股份有限公司 | External composition for preventing, relieving or treating skin allergy and application thereof |
| CN111012694A (en) * | 2019-12-30 | 2020-04-17 | 华熙生物科技股份有限公司 | Hyaluronic acid-containing spray for repairing and moisturizing soles and preparation method thereof |
| CN111588652A (en) * | 2020-05-14 | 2020-08-28 | 华熙生物科技股份有限公司 | Composition containing hyaluronic acid and polyalcohol and application thereof |
| CN111588652B (en) * | 2020-05-14 | 2023-03-10 | 华熙生物科技股份有限公司 | Composition containing hyaluronic acid and polyalcohol and application thereof |
| CN116059241A (en) * | 2021-11-04 | 2023-05-05 | 华熙生物科技股份有限公司 | Composition containing hyaluronic acid or salt thereof for improving immunity and promoting gastrointestinal health and application thereof |
| CN114365846A (en) * | 2021-12-14 | 2022-04-19 | 浙江瘦金体健康管理集团有限公司 | Hyaluronic acid oral liquid and preparation method and application thereof |
| CN116098827A (en) * | 2022-12-07 | 2023-05-12 | 华熙生物科技股份有限公司 | Use of oligopeptides for improving vitamin and/or amino acid stability |
| CN116999369A (en) * | 2023-06-27 | 2023-11-07 | 山东福瑞达生物股份有限公司 | Anti-aging compound containing hyaluronic acid and plant extract and preparation method thereof |
| CN116999369B (en) * | 2023-06-27 | 2024-08-16 | 山东福瑞达生物股份有限公司 | Anti-aging compound containing hyaluronic acid and plant extract and preparation method thereof |
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