CN107802587A - Moisturizing facial cleanser containing stem cell growth factors and preparation method and application thereof - Google Patents

Moisturizing facial cleanser containing stem cell growth factors and preparation method and application thereof Download PDF

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Publication number
CN107802587A
CN107802587A CN201711278695.XA CN201711278695A CN107802587A CN 107802587 A CN107802587 A CN 107802587A CN 201711278695 A CN201711278695 A CN 201711278695A CN 107802587 A CN107802587 A CN 107802587A
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Prior art keywords
stem cell
cell factor
mildy wash
containing stem
mixture
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CN201711278695.XA
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Inventor
葛啸虎
陈海佳
王飞
王一飞
王小燕
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Guangzhou Saliai StemCell Science and Technology Co Ltd
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Guangzhou Saliai StemCell Science and Technology Co Ltd
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Priority to CN201711278695.XA priority Critical patent/CN107802587A/en
Publication of CN107802587A publication Critical patent/CN107802587A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/604Alkylpolyglycosides; Derivatives thereof, e.g. esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/007Preparations for dry skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/596Mixtures of surface active compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86Products or compounds obtained by genetic engineering

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)

Abstract

The invention belongs to the field of skin care products, and particularly relates to a moisturizing facial cleanser containing stem cell growth factors, and a preparation method and application thereof. The moisturizing facial cleanser containing the stem cell growth factor comprises the following components in percentage by mass: human stem cell growth factor 0.00005-0.0001%; 10.3 to 0.5 percent of dipeptide; 0.5-0.8% of yeast polypeptide; 3-5% of a nostoc commune extract; 1-3% of kiwi fruit extract; 0.05-0.1% of sodium hyaluronate; 5-8% of glycerol; 1-2% of jojoba oil; 15-25% of a surfactant; 0.5-2% of an emulsifier; 1-3% of a thickening agent; water makes up to 100%. The moisturizing facial cleanser containing the stem cell growth factor provided by the invention has strong skin-friendly property, is beneficial to skin absorption, can protect and repair a skin lipid membrane, has the effects of enabling the skin to be smooth, fine and elastic, supplementing moisture, collagen and the like, and is suitable for dry skin.

Description

A kind of moisturizing mildy wash containing stem cell factor and preparation method and application
Technical field
The invention belongs to skin care field, and in particular to a kind of moisturizing mildy wash and its preparation containing stem cell factor Method and application.
Background technology
The first element for wanting to possess the pale moist skin of health is exactly that needs possess healthy sebum film.The sebum of health Film is in faintly acid, and pH maintains 4.5~6.5 weakly acidic states, and sebum film can suppress and kill the bacterium of skin surface, with Keep the health of skin.The purpose of face cleaning is to clean skin surface oxidized sebum and dust, unabsorbed skin care products and Color make-up etc..And incorrect face cleaning mode and face cleaning product can hurt this layer of healthy sebum film, make sebum film increasingly Thin, the immunity degradation and water lock function of skin weaken, and form various skin problems:Drying, pigment, sensitivity, or even long acne etc.. So the healthy skin first step is exactly correct face cleaning and selection face cleaning product.
Mildy wash is that sales volume rises faster a kind of face cleaning product in recent years, and its decontamination mechanism is to utilize surface-active Agent reduces the surface tension of dirt, by soaking, disperseing, foaming, the effect such as emulsifying and remove dirt.Domestic face's cleaning production at present Kind class is various, particularly may be divided into soap base type and the class of non-soap fundamental mode two.Soap base type contains fatty acid soaps composition, foaming abundancy, easily In flushing, but product slightly stimulates, and washing rear skin has tight feeling.Non-soap basic product has soapy feeling after washing, because of the surface of compounding Activating agent is different, and foaming power, cleaning strength and excitant are all different, if any non-soap basic product in order to improve foaming power, wash Resulting net force and cost is reduced, the alkalescence such as lauryl sodium sulfate, Coconut Fatty Acid Monoethanolamide table larger compared with strong, excitant can be added Face activating agent, if long-term use of this kind of product can destroy sebum film, skin is highly susceptible to external injury.Once lose sebum Film, skin are highly susceptible to external injury.Some non-soap basic product foams are not abundant enough, and dirt-removing power is poor, feels after washing It is greasy.
The performance of face cleaning product is improved comprehensively, while with the face cleaning functions such as facial dust, grease are removed, is also had The effect of skin health is safeguarded, is not only the skin care method and development trend of face cleaning product science, while is also consumers in general Growing demand.For this reason, it is necessary to it is good to research and develop a kind of cleaning effect, it is gentle non-stimulated, and cost is low, can be long-term use of clean Face breast.
The content of the invention
For overcome the deficiencies in the prior art and shortcoming, primary and foremost purpose of the invention is that providing one kind contains stem cell growth The moisturizing mildy wash of the factor.
Another object of the present invention is to provide the preparation method of the above-mentioned moisturizing mildy wash containing stem cell factor.
It is still another object of the present invention to provide the application of the above-mentioned moisturizing mildy wash containing stem cell factor.
The purpose of the present invention is achieved through the following technical solutions:
A kind of moisturizing mildy wash containing stem cell factor, includes component as follows by mass percentage:
The described moisturizing mildy wash containing stem cell factor, preferably comprise following component by mass percentage:
Described human stem cell growth is preferably:The restructuring human stem cell growth prepared with gene engineering method Or the people source human stem cell growth that application cell nutrient solution is naturally isolated;
Described human stem cell growth is more preferably at least one of hSCGF- α and hSCGF- β;
Described yeast polypeptides are preferably yeast polypeptides made from autolysis method or enzyme hydrolysis method;
Described surfactant is preferably the mixture of APG and laureth sulfosuccinate disodium;
Described APG and the mass ratio of laureth sulfosuccinate disodium are preferably (1~2):(0.5~ 1);
Described emulsifying agent is preferably glyceryl stearate, PEG-100 stearates, polyoxyethylene sorbitan fat At least one of acid esters and Span;
Described thickener is preferably the mixture of sodium alginate and PEG-120 methyl dioleates;
Described sodium alginate and the mass ratio of PEG-120 methyl dioleates are preferably (2~4):1;
The preparation method of the described moisturizing mildy wash containing stem cell factor, is comprised the following steps:
(1) jojoba oil, surfactant, emulsifying agent and thickener are mixed, dissolves by heating and stir, mixed Compound 1;
(2) Sodium Hyaluronate, G & W are mixed, stirs, obtain mixture 2;
(3) mixture 1 made from step (1) is added into vacuum emulsifying in mixture 2 made from step (2), obtained Mixture 3;
(4) when mixture 3 made from step (3) is cooled to below 45 DEG C, remaining ingredient is added to step (3) and is made Mixture 3 in, stir;Obtain the moisturizing mildy wash containing stem cell factor;
The principle of the present invention:
If stem cell factor as caused by stroma cell it is a kind of stimulate early stage candidate stem cell and progenitor cell proliferation, The hemopoieticgrowth factor of colonization, it is hemopoietic stem cell proliferation differentiation key factor, there is various biological function;Dipeptides -1 is by 2 Individual amino acid institute is into can resist pouch and eye edema, make the skin consolidation, flexible of eye.Yeast polypeptides are Yeast proteins Obtained biologically active polypeptide is isolated and purified after biological enzymolysis, is currently used primarily in field of food.Distilled Nostoc Commune is to hydroxyl Free radical (OH) and hydrogen peroxide (H2O2) have good Scavenging activity, and percentage of water loss is low, ultraviolet absorption ability is strong, tool Have good anti-oxidant, moisturizing and ultraviolet radiation protective effect, Kiwi extract rich in natural tartaric acid, inorganic salts, mineral matter, Sugar, vitamin C etc., there is the functions such as moisturizing, nursing skin.The present invention is active by above-mentioned peptides active component and plant extracts Composition carries out science compounding, and skin can quickly absorb, effective activation cell, makes skin profit, acid-base balance, protection and reparation skin Adipose membrane, skin elasticity is improved, water humidity, smoothness greatly improve.
The present invention is had the following advantages relative to prior art and effect:
(1) the moisturizing mildy wash provided by the invention containing stem cell factor contains peptides active component and plant extract Thing active component, skin-friendly is strong, beneficial to percutaneous absorption.
(2) sebum film can be protected and repaired to the moisturizing mildy wash provided by the invention containing stem cell factor, and having makes The smooth exquisiteness of skin is flexible, keeps the skin wet with collagen and other effects.
(3) the moisturizing mildy wash provided by the invention containing stem cell factor uses compound surfactant, wherein, it is non- The compounding of ionic surface active agent APG and anion surfactant laureth sulfosuccinate disodium, can make System stability strengthens.
(4) the moisturizing mildy wash provided by the invention containing stem cell factor can safeguard the acidity of skin, not hinder gently Skin, foaming abundancy, no tight feeling, skin protection function can be recovered after clean skin rapidly, make skin profit, acid-base balance, protect Moist strong, water humidity, smoothness greatly improve, and suitable dry skin simultaneously can be long-term use of.
Embodiment
With reference to embodiment, the present invention is described in further detail, but the implementation of the present invention is not limited to this.
Stem cell factor is hSCGF- α in embodiment, purchased from Peprotech companies;Yeast polypeptides (specification 20:1) Purchased from Lanzhou water Lai Si bio tech ltd, distilled Nostoc Commune (specification 20:1) winning woods biotechnology purchased from Shaanxi has Limit company, Kiwi extract (specification 20:1) it is purchased from Xi'an Ming Ze bio tech ltd;
Embodiment 1
A kind of moisturizing mildy wash containing stem cell factor, includes component as follows by mass percentage:
The preparation method of the described moisturizing mildy wash containing stem cell factor, is comprised the following steps:
(1) by jojoba oil, surfactant (APG APG0810 and laureth sulfosuccinate disodium, Mass ratio 1:1), emulsifying agent and thickener (sodium alginate and PEG-120 methyl dioleates, mass ratio 3:1) mix, add Heat of solution simultaneously stirs, and obtains mixture 1;
(2) Sodium Hyaluronate, G & W are mixed, stirs, obtain mixture 2;
(3) mixture 1 made from step (1) is added into vacuum emulsifying in mixture 2 made from step (2), obtained Mixture 3;
(4) when mixture 3 made from step (3) is cooled to 37 DEG C, remaining ingredient is added to made from step (3) and mixed In compound 3, stir;Obtain the moisturizing mildy wash containing stem cell factor.
Embodiment 2
A kind of moisturizing mildy wash containing stem cell factor, includes component as follows by mass percentage:
The preparation method of the described moisturizing mildy wash containing stem cell factor, is comprised the following steps:
(1) by jojoba oil, surfactant (APG APG0810 and laureth sulfosuccinate disodium, Mass ratio is 2:0.5), emulsifying agent and thickener (sodium alginate and PEG-120 methyl dioleates, mass ratio 2:1) mix Close, dissolve by heating and stir, obtain mixture 1;
(2) Sodium Hyaluronate, G & W mixing, stir, obtain mixture 2;
(3) mixture 1 made from step (1) is added into vacuum emulsifying in mixture 2 made from step (2), obtained Mixture 3;
(4) when mixture 3 made from step (3) is cooled to 40 DEG C, remaining ingredient is added to made from step (3) and mixed In compound 3, stir;Obtain the moisturizing mildy wash containing stem cell factor.
Embodiment 3
A kind of moisturizing mildy wash containing stem cell factor, includes component as follows by mass percentage:
The preparation method of the described moisturizing mildy wash containing stem cell factor, is comprised the following steps:
(1) by jojoba oil, surfactant (APG APG0810 and laureth sulfosuccinate disodium, Mass ratio is 1.2:0.8), emulsifying agent and thickener (sodium alginate and PEG-120 methyl dioleates, mass ratio 4:1) Mixing, dissolves by heating and stirs, obtain mixture 1;
(2) Sodium Hyaluronate, G & W mixing, stir, obtain mixture 2;
(3) mixture 1 made from step (1) is added into vacuum emulsifying in mixture 2 made from step (2), obtained Mixture 3;
(4) when mixture 3 made from step (3) is cooled to 45 DEG C, remaining ingredient is added to made from step (3) and mixed In compound 3, stir;Obtain the moisturizing mildy wash containing stem cell factor.
Comparative example 1
A kind of moisturizing mildy wash, includes component as follows by mass percentage:
The preparation method of described moisturizing mildy wash, is comprised the following steps:
(1) by jojoba oil, surfactant (APG APG0810 and laureth sulfosuccinate disodium, Mass ratio 2:0.8), emulsifying agent and thickener (sodium alginate and PEG-120 methyl dioleates, mass ratio 3:1) mix, Dissolve by heating and stir, obtain mixture 1;
(2) Sodium Hyaluronate, G & W are mixed, stirs, obtain mixture 2;
(3) mixture 1 made from step (1) is added into vacuum emulsifying in mixture 2 made from step (2), obtained Mixture 3;
(4) when mixture 3 made from step (3) is cooled to 37 DEG C, remaining ingredient is added to made from step (3) and mixed In compound 3, stir;Obtain moisturizing mildy wash.
Comparative example 2
A kind of moisturizing mildy wash, includes component as follows by mass percentage:
The preparation method of described moisturizing mildy wash, is comprised the following steps:
(1) by jojoba oil, surfactant (laureth sulfosuccinate disodium), emulsifying agent and thickener (PEG-120 methyls dioleate) mixes, and dissolves by heating and stirs, obtains mixture 1;
(2) Sodium Hyaluronate, G & W mixing, stir, obtain mixture 2;
(3) mixture 1 made from step (1) is added into vacuum emulsifying in mixture 2 made from step (2), obtained Mixture 3;
(4) when mixture 3 made from step (3) is cooled to 37 DEG C, remaining ingredient is added to made from step (3) and mixed In compound 3, stir;Obtain moisturizing mildy wash.
Effect example
(1) foaming power and foam stability test
Each face cleaning milk solution 3mL that weight/mass percentage composition is 10% is prepared respectively, is placed in 50mL tool plug graduated cylinders, is added distillation Water is diluted to 15mL, capping, acutely concussion 10 times, immediate record foam volume (mL), and foam volume is recorded again after 10min Replication 3 times, averages.
As a result as shown in table 1, compared with comparative example 1 and 2, mildy wash foaming power and foam are steady made from embodiment 1 It is qualitative more excellent.
The foaming power of table 1 and foam stability test result analysis
Test event Embodiment 1 Comparative example 1 Comparative example 2
Foam cumulative volume/mL 35.6 33.5 27.3
Foam volume/mL after 10min 28.7 26.2 24.9
(2) moisture retention is tested
60 female volunteers are chosen, the age between 25~40 years old, skin health, no skin disease allergies, divides at random For three groups.Volunteer is cleaned after face using clear water and tests forehead, left face, right face and chin respectively using skin moisture detector The moisture of skin;Subject reuses warm water moistening face, is then made using embodiment 1 and comparative example 1~2 Mildy wash cleaning face, cleaned with clear water, then forehead, left face, right face and the same position of chin are tested with skin moisture tester The skin moisture content put, skin moisture tester is reused after 24 hours and is tested one time.
As a result as shown in table 2, compared with comparative example 1 and 2, mildy wash made from embodiment 1 has good moisturizing Property.
The moisture retention test result analysis of table 2
Test event Use preceding content (%) Use rear content (%) Use content after 24h (%)
Embodiment 1 23.3% 27.8% 25.4%
Comparative example 1 23.6% 22.9% 19.3%
Comparative example 2 23.1% 23.5% 20.7%
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification, Equivalent substitute mode is should be, is included within protection scope of the present invention.

Claims (10)

1. a kind of moisturizing mildy wash containing stem cell factor, it is characterised in that include group as follows by mass percentage Point:
2. the moisturizing mildy wash according to claim 1 containing stem cell factor, it is characterised in that comprising pressing matter as follows Measure the component of percentages:
3. the moisturizing mildy wash according to claim 1 or 2 containing stem cell factor, it is characterised in that:
Described human stem cell growth is at least one of hSCGF- α and hSCGF- β.
4. the moisturizing mildy wash according to claim 1 or 2 containing stem cell factor, it is characterised in that:
Described yeast polypeptides are yeast polypeptides made from autolysis method or enzyme hydrolysis method.
5. the moisturizing mildy wash according to claim 1 or 2 containing stem cell factor, it is characterised in that:
Described surfactant is the mixture of APG and laureth sulfosuccinate disodium.
6. the moisturizing mildy wash according to claim 5 containing stem cell factor, it is characterised in that:
Described APG and the mass ratio of laureth sulfosuccinate disodium are (1~2):(0.5~1).
7. the moisturizing mildy wash according to claim 1 or 2 containing stem cell factor, it is characterised in that:
Described emulsifying agent is glyceryl stearate, PEG-100 stearates, polyoxyethylene sorbitan fatty acid ester and mountain At least one of pears alcohol fatty acid ester.
8. the moisturizing mildy wash according to claim 1 or 2 containing stem cell factor, it is characterised in that:
Described thickener is the mixture of sodium alginate and PEG-120 methyl dioleates.
9. the moisturizing mildy wash according to claim 8 containing stem cell factor, it is characterised in that:
Described sodium alginate and the mass ratio of PEG-120 methyl dioleates are (2~4):1.
10. the preparation method of the moisturizing mildy wash containing stem cell factor described in any one of claim 1~9, its feature It is to comprise the following steps:
(1) jojoba oil, surfactant, emulsifying agent and thickener are mixed, dissolves by heating and stir, obtain mixture 1;
(2) Sodium Hyaluronate, G & W mixing, stir, obtain mixture 2;
(3) mixture 1 made from step (1) is added into vacuum emulsifying in mixture 2 made from step (2), mixed Thing 3;
(4) when mixture 3 made from step (3) is cooled to below 45 DEG C, remaining ingredient is added to made from step (3) and mixed In compound 3, stir;Obtain the moisturizing mildy wash containing stem cell factor.
CN201711278695.XA 2017-12-06 2017-12-06 Moisturizing facial cleanser containing stem cell growth factors and preparation method and application thereof Withdrawn CN107802587A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108514542A (en) * 2018-05-11 2018-09-11 深圳市旷逸生物科技有限公司 A kind of moisturizing mildy wash and the preparation method and application thereof containing stem cell factor
CN108743921A (en) * 2018-05-24 2018-11-06 广州芬森医学科技有限公司 It is a kind of to prevent the reparation liquid and its preparation method and application that scar is formed
CN113425618A (en) * 2020-03-23 2021-09-24 王福芳 Composite active peptide facial cleanser and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
中华人民共和国卫生部: "《化妆品卫生规范》", 31 January 2007 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108514542A (en) * 2018-05-11 2018-09-11 深圳市旷逸生物科技有限公司 A kind of moisturizing mildy wash and the preparation method and application thereof containing stem cell factor
CN108743921A (en) * 2018-05-24 2018-11-06 广州芬森医学科技有限公司 It is a kind of to prevent the reparation liquid and its preparation method and application that scar is formed
CN113425618A (en) * 2020-03-23 2021-09-24 王福芳 Composite active peptide facial cleanser and preparation method thereof

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