KR102571226B1 - Composition for improving scalp condition comprising gluconolactone and climbazole as active ingredients - Google Patents

Abstract

The composition for improving scalp condition of the present disclosure has a remarkably excellent anti-inflammatory effect through the synergistic effect of the combination of gluconolactone and climbazole, thereby significantly improving dandruff, scalp itching, scalp thickening keratin, or seborrheic scalpitis. great. In addition, the composition for improving scalp conditions of the present disclosure has a remarkably excellent effect of strengthening the scalp barrier by reducing transepidermal water loss. In addition, the composition for improving scalp conditions of the present disclosure is remarkably excellent in improving keratin exfoliation, improving scalp odor, or improving scalp irritation.

Description

Composition for improving scalp condition comprising gluconolactone and climbazole as active ingredients

The present disclosure relates to a composition for improving scalp conditions.

In modern society, most people use a lot of different products to cleanse and clean their scalp and hair. However, since the main components of these products include surfactants, foam enhancers, emulsifiers, thickeners, and preservatives, there is a concern of causing irritation and itching to the scalp.

In addition, many people use hair dyes or perms to change their hairstyles for cosmetic purposes. In the case of some sensitive scalps, damage to the scalp may occur due to physical and chemical stimulation caused by hair dyes or perm agents.

In addition, changes in temperature or humidity during daily life, exposure from sunlight, or pollutants such as fine dust can also stimulate the scalp, and the condition of the scalp can also be deteriorated by stress or nutritional deficiency.

The scalp is composed of epidermis, dermis, and subcutaneous tissue. In general, turn-over proceeds in the epidermal stratum corneum of the scalp, and is replaced with a new stratum corneum at a cycle of about one month. In the case of a healthy scalp, when the stratum corneum turns over, small-sized keratin is eliminated and replaced with new keratinocytes. However, when the turnover is out of the normal state and the keratinocytes are partially excessive, there are cases in which lumps are visibly lumped together and eliminated, which is called dandruff. Although dandruff is a problem of the scalp, it is not a major problem for human health, and although there are differences in degree, it is a phenomenon that occurs in the scalp of most people.

The known causes of dandruff include increased secretion of sebum on the scalp, increased proliferation and activity of microorganisms, abnormal keratinization due to abnormal scalp metabolism, or stimulation of the scalp by fatty acids generated by lipase.

In addition, when a lot of dandruff occurs, physical stimulation such as scratching or rubbing the scalp may be given due to itching, which may cause scarring or inflammation. The itching that occurs at this time is also induced by mediating histamine and arachidonic acid metabolites, which cause a complex inflammatory reaction and stimulate nerve cells to induce itching.

In addition, in relation to the symptoms of dandruff, sebum secretion and sweat from the scalp and keratolysis by microorganisms cause body odor on the scalp. As these waste products oxidize, the scalp can emit an unpleasant odor. The smell of the scalp is related to the distribution of microorganisms, and the scalp creates an environment (hair, humidity, etc.) in which microorganisms can live more than other skin parts.

Zinc pyrithione is the most commonly used active ingredient in anti-dandruff shampoos currently on the market. Zinc pyrithione has an antimicrobial effect, has a high specific gravity, is insoluble in water, and is difficult to maintain a dispersed state in a formulation. In addition, since zinc pyrithione has irritant properties, products that can replace it with other ingredients are gradually being researched and developed in Korea.

There have been attempts to suppress the generation of dandruff or improve scalp itching by applying or taking natural ingredients such as existing plant extracts on the scalp, but these have not been significantly effective in improving dandruff, excessive keratin exfoliation, keratin thickening, or itching. There are downsides. Therefore, there is a need to develop a composition for improving scalp condition that is effective in improving dandruff, exfoliation of excessive keratin, thickening of keratin, or itching.

The problem to be solved by the present disclosure is to provide a composition for improving the scalp condition that is safe to the human body, has excellent formulation stability, and can keep the scalp healthy.

As a result of diligent efforts to develop a composition that can effectively improve scalp condition, the inventors of the present invention have found that when gluconolactone and climbazole are used in combination as active ingredients of the composition for improving scalp condition, the scalp condition is remarkably It was confirmed that it was improved. Specifically, the composition for improving scalp conditions of the present disclosure has a remarkably excellent anti-inflammatory effect through the synergistic effect of the combination of gluconolactone and climbazole, thereby improving dandruff, scalp itching, keratin exfoliation, scalp thickening keratin Improvement and seborrheic scalp inflammation improvement effects are remarkably excellent. In addition, the composition for improving scalp conditions of the present disclosure has a remarkably excellent effect of strengthening the scalp barrier by reducing transepidermal water loss. In addition, through sensory evaluation, the present inventors found that the composition for improving scalp condition has significant effects such as improving scalp itching, dandruff, keratin exfoliation, scalp thickening, keratin, scalp odor, and scalp irritation. The excellence was confirmed to complete the present invention.

The present disclosure provides a composition for improving scalp condition comprising gluconolactone and climbazole as active ingredients. The composition for improving scalp condition can significantly inhibit the secretion of inflammatory factors to improve dandruff, scalp itching, thickened keratin on the scalp, or seborrheic scalpitis, and the effect of improving keratin exfoliation or improving scalp odor is also remarkably excellent. The inflammatory factor may be, for example, interleukin-8, etc., but is not limited thereto. In addition, the composition can strengthen the scalp barrier by reducing the amount of transepidermal water loss in the scalp.

In one embodiment of the present disclosure, the gluconolactone may be included in an amount of 0.001 to 20% by weight, preferably 0.01 to 10% by weight, based on the total weight of the composition. In addition, the climbazole may be included in an amount of 0.001 to 20% by weight, preferably 0.001 to 5% by weight, more preferably 0.01 to 0.5% by weight, based on the total weight of the composition. When the amount of gluconolactone and climbazole is less than 0.001% by weight, respectively, the scalp condition improvement effect is insignificant, and when the content is greater than 20% by weight, formulation stability is not preferred.

In one embodiment of the present disclosure, the weight ratio of gluconolactone and climbazole may be 1:0.01 to 10, preferably 1:0.03 to 5, more preferably 1:0.05 to 3 (gluconolactone:climbazole). there is. When the weight ratio of the two components is within the above range, the scalp condition improving effect of the composition for improving scalp condition is remarkably excellent.

In one embodiment of the present disclosure, the composition for improving scalp condition may be formulated in any form that can be applied to the skin, but may be formulated in the form of an external application. For example, the composition for improving scalp condition may be prepared in a formulation that can be applied to the skin, such as liquid, cream, paste, spray, or solid.

In one embodiment of the present disclosure, the composition for improving scalp condition may be a cosmetic composition or a functional cosmetic composition, and the cosmetic composition or functional cosmetic composition is prepared by adding conventional ingredients through a conventional method in the cosmetic technology field. It can be. In addition, the composition for improving the condition of the scalp may be a pharmaceutical or quasi-drug composition.

In one embodiment of the present disclosure, when the formulation of the composition is liquid, a solvent, solubilizing agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate , propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic esters, polyethylene glycol or sorbitan fatty acid esters may be used.

In one embodiment of the present disclosure, when the formulation of the composition is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, Talc or zinc oxide or the like may be used.

In one embodiment of the present disclosure, when the formulation of the composition is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier component. In particular, when the formulation of the composition is a spray, it may additionally include a propellant such as chlorofluorohydrocarbon, propane/butane or dimethyl ether.

In one embodiment of the present disclosure, the components included in the composition include components commonly used in external preparations that can be applied to the skin other than gluconolactone and climbazole, for example, water, surfactants, moisturizers, low-grade One or more additives selected from the group consisting of alcohols, chelating agents, bactericides, antioxidants, preservatives, coloring agents and flavoring agents may be further included.

In addition, the present disclosure provides a scalp improvement method comprising administering or applying the composition to a subject or subject skin in need of scalp improvement, and/or improving the scalp of the subject or subject's skin. Preferably, the scalp improvement may be dandruff improvement, scalp itching improvement, scalp thickening keratin improvement, seborrheic scalpitis improvement, keratin exfoliation improvement, or scalp odor improvement.

In one embodiment of the present disclosure, the composition for improving scalp condition may be prepared as a shampoo formulation (Preparation Example 1).

In the present disclosure, the composition for improving scalp condition may be used as a transdermal administration method such as direct application or spraying to the skin. When the composition is a shampoo formulation, it is preferable to apply it to the scalp and hair by lathering it in a general shampoo method and then washing.

In the context of this disclosure, the term “administering” means introducing a composition of this disclosure by any suitable method. The administration route of the composition of the present disclosure may be administered through any general route as long as it can reach the target tissue. Preferably, the composition can be administered transdermally, preferably applied topically. The number of applications of a composition of the present disclosure may be determined according to prescription, need, or desire.

In addition, the present disclosure provides a hair or scalp product comprising the composition for improving scalp condition. The hair or scalp products may be added with conventional additives, scalp clinic agents, scalp scaling agents, scalp massage agents, scalp care agents, shampoos, tonics, hair conditioners, hair lotions, gels, and packs for improving scalp condition. , creams, essences, powders, sprays, oils, soaps, ointments, hair styling agents, hair restorers, hair dyes, and products such as perms, but are not limited thereto. In addition, the composition for improving scalp conditions may also be used in the form of an aerosol type of the formulations. In addition, the composition of the present disclosure may be prepared as a composition or product used for eyebrows or eyelashes in addition to the scalp.

In one embodiment of the present disclosure, the amount of the composition for improving scalp conditions may be appropriately adjusted according to individual differences such as age, severity of lesions, or formulation. Preferably, the amount of the composition for improving the scalp condition can be used continuously for one week to several months on the scalp in an appropriate amount, usually once to several times a day. In Experimental Example 1 of the present disclosure, the synergistic effect of gluconolactone and climbazole on inflammation inhibition was confirmed. In Experimental Example 2, when the composition for improving scalp condition of the present disclosure was used at 3 ml once daily for 14 days, it was confirmed that the effect of improving scalp condition was remarkably superior to that of Comparative Example.

All ingredients described in the present disclosure are preferably, related laws and regulations of Korea, China, the United States, Europe, Japan, etc. (e.g., Regulations on Cosmetics Safety Standards, etc. (Korea), Cosmetics Safety Technical Standards (China), Food Codex (Korea), Food Additive Codex Codex (Korea), Health Functional Food Codex (Korea)), etc.) Do not exceed the maximum usage value. That is, preferably, a composition for improving scalp conditions, a cosmetic composition, a functional cosmetic composition, a pharmaceutical composition, or a quasi-drug composition according to the present disclosure includes the components according to the present disclosure within the content limit permitted by the relevant laws and regulations of each country.

The composition for improving scalp condition of the present disclosure has a remarkably excellent anti-inflammatory effect through the synergistic effect of the combination of gluconolactone and climbazole, thereby improving dandruff, scalp itching, keratin thickening, or seborrheic scalpitis. This is remarkably excellent. In addition, the composition for improving scalp conditions of the present disclosure has a remarkably excellent effect of strengthening the scalp barrier by reducing the amount of transepidermal water loss in the scalp. In addition, the composition for improving scalp conditions of the present disclosure is remarkably excellent in improving keratin exfoliation, improving scalp odor, or improving scalp irritation.

1 is a graph showing the effect of improving TEWL (transepidermal water loss) when using a shampoo containing gluconolactone and climbazole.
2 is an image showing that thickened keratin is improved when using a shampoo containing gluconolactone and climbazole.
3 is a graph showing that scalp itchiness, dead skin cell loss, scalp odor and irritation are improved when using a shampoo containing gluconolactone and climbazole.

Hereinafter, examples and the like will be described in detail to aid understanding of the present invention. However, the embodiments according to the present invention can be modified in many different forms, and the scope of the present invention should not be construed as being limited to the following examples. Embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

Experimental Example 1: Confirmation of inflammation inhibitory effect

(1) Evaluation of inflammatory response inhibition rate

In order to confirm the anti-inflammatory activity of gluconolactone and climbazole, the ability to inhibit production of nitric oxide (NO), one of the substances that induce inflammation, was analyzed. RAW 264.7 cells used in the experiment are a murine macrophage cell line, which is used as a main model for anti-inflammatory active cell experiments, and was purchased from ATCC (American Type Tissue Collection). The RAW 264.7 cells were cultured in RPMI1640 (Gibco) medium containing 10% FBS (fetal bovine serum, Gibco) and 1% penicillin/streptomycin (Gibco).

In order to confirm the anti-inflammatory activity of gluconolactone and climbazole, the RAW 264.7 cells were attached to a 96-well plate at 2.0 x 10 ⁴ cells per well and cultured for 24 hours. Thereafter, 1 μg/mL of lipopolysaccharide (LPS), gluconolactone, and climbazole were simultaneously treated for 24 hours, and the NO production inhibitory ability was analyzed through a Griess reaction.

The grease reaction is a method for quantitatively analyzing the amount of NO produced from cells treated with a sample and released into the culture medium. The grease reaction solution is prepared by mixing 1% sulfanilamide solution and 0.1% naphthylenediamine dihydrochloride solution dissolved in 5% phosphoric acid solution in a ratio of 1:1.

Take 50 μL of the cell culture solution in which the sample was treated for 24 hours from each well and distribute it to a 96-well plate. Thereafter, the prepared grease reaction solution was dispensed in an amount of 50 μL per well in the same amount as the cell culture medium, and the color change according to NO production and inhibition was measured by absorbance at 540 nm using a multi-plate reader. Experimental results were expressed as the average of three repetitions for each gluconolactone and climbazole treatment combination.

In addition, in order to confirm whether gluconolactone and climbazole induce cytotoxicity, CCK-8 assay (Cell Counting Kit-8, Dojindo) was performed using 50 μL of the cell culture medium. CCK-8 assay is one of the methods for measuring cell viability. After adding 1/10 of the assay reaction solution of the cell culture medium and reacting at 37 ° C for one hour, the absorbance at 450 nm is measured using a multi-plate reader. It was measured, and no cytotoxicity was observed between the measured concentrations.

The NO inhibitory activity induced by LPS was expressed as a percentage of the control (A) in which both LPS and the sample were not treated and the control (B) in which only LPS was added and no sample was added. The formula for calculating the percentage of anti-inflammatory activity in each sample (C) is as follows.

Inflammation inhibitory activity (%) = {(B-C)/(B-A)} Х 100

The A is the absorbance of the control group in which both LPS and the sample are not treated at 540 nm, the B is the absorbance of the control group treated only with LPS at 540 nm, and the C is the absorbance of the experimental group co-treated with LPS at 540 nm .

The calculated values for the inflammatory response inhibitory activities of gluconolactone and climbazole according to the present disclosure are shown in Table 1 below.

processing sample A ₅₄₀ Inflammation response inhibition rate (%) A untreated control - - 0.274 - B LPS 1 µg/mL - - 1.565 0 C Gluconolactone 6.25 µM 1.494 5.53 25 µM 1.516 3.81 Climbazole 6.25 µM 1.356 16.18 25 µM 1.247 24.65 Gluconolactone 6.25 μM + Climbazole 6.25 μM 1.285 21.70 Gluconolactone 25 μM + Climbazole 25 μM 1.158 31.49

Looking at the experimental results described in Table 1 above, it was confirmed that gluconolactone or climbazole inhibited the inflammatory response, respectively, and in particular, when gluconolactone and climbazole were co-treated, the inflammatory response inhibition rate was remarkably increased. You can check.

(2) Examination of synergistic effects of gluconolactone and climbazole on inflammation inhibition

When gluconolactone and climbazole were used together, the expected expected value (inhibition rate of inflammatory response) was calculated using the Colby equation. The calculation process and results are shown below. "Synergistic effect" means as defined in ["Calculation of the synergistic and antagonistic responses of herbicide combinations" Weeds, (1967), 15, pp. 20-22].

Colby formula: Expected value = A + B - (A х B / 100)

A: Observed potency of active component A at the same concentration as used in the mixture

B: Observed potency of potency component B at the same concentration as used in the mixture

In order to calculate the expected inflammatory response inhibition rate (expected value) when gluconolactone and climbazole are used together, the inflammatory response inhibition rate of the experimental group treated with only LPS and gluconolactone is substituted into A of the Colby equation, and LPS and After calculating the expected value according to Colby's equation by substituting the inflammatory response inhibition rate of the experimental group treated with only climbazole, the value is shown in Table 2 below.

In addition, the degree of synergistic effect was calculated and shown together in Table 2 below, and the numerical values in Table 2 were rounded to the second decimal place and indicated only to the first decimal place.

processing sample Actual inflammatory response inhibition rate (%) Inflammation response inhibition rate
Expected Value (%) Synergistic effect (%) One Gluconolactone 6.25 μM + Climbazole 6.25 μM 21.7 20.8 4.3 2 Gluconolactone 25 μM + Climbazole 25 μM 31.5 27.5 14.4

Looking at the results shown in Table 2 above, in the case of the actual inflammatory response inhibition rate when gluconolactone and climbazole were actually used together, the combination using 25 μM of each of the two substances was higher than the expected value predicted when gluconolactone and climbazole were used together It can be seen that there is an increase of about 14.4% in That is, it can be seen that the combination of gluconolactone and climbazole exhibits a remarkable synergistic effect in suppressing the inflammatory response.

Experimental Example 2: Scalp condition improvement evaluation

In order to confirm the efficacy of the composition for improving scalp condition prepared according to the present disclosure, a composition (shampoo) for improving scalp condition containing gluconolactone and climbazole was prepared in Example 1, and Comparative Example 1 was gluconolactone and a composition not containing climbazole (see Table 8).

As for the experimental group, 12 adults aged 26 to 45 years old with scalp itching were divided into two groups of 6 each, and the experiment was conducted. The evaluation product was a wash-off shampoo type, and after using 3 ml of the product once a day for 2 weeks, the degree of improvement of the scalp condition was evaluated with the following items.

(1) Evaluation of scalp transepidermal water loss (TEWL)

The amount of transepidermal water loss indicates the degree of evaporation of water inside the skin, and tends to increase when the barrier function of the skin is damaged.

In order to measure the amount of transepidermal water loss on the scalp of the test subjects who had been washing their hair for more than 8 hours after washing their hair, they waited for 20 minutes under constant temperature and humidity conditions (23 ° C., 40% relative humidity) to apply the scalp. After 20 minutes of acclimatization, the transepidermal water loss at the 4 intersections of the crown, parietal region, frontal region, occipital region, and the midline of the head was measured using a transepidermal water loss measuring instrument (Tewameternano probe, MPA6, C+K Electronic Co., Germany).

Then, the composition for improving scalp condition (Comparative Example 1, Example 1) was used for 2 weeks, respectively, and the amount of transdermal water loss in the same area was measured after 1 week and 2 weeks of using the composition. One of the personnel using Comparative Example 1 stopped the test midway.

The measurement results are shown in Table 3 and FIG. 1 below as averages of 5 people in each Comparative Example 1 group and 6 people in Example 1 group.

TEWL (g/hm ² ) TEWL improvement rate (%) 0 weeks 1 week 2 weeks 0 weeks 1 week 2 weeks Comparative Example 1 38.1 37.3 36.5 - 2.0 4.1 Example 1 39.0 38.0 36.3 - 2.7 7.1

As can be seen in Table 3 and FIG. 1, when Example 1, which is a composition for improving scalp condition containing gluconolactone and climbazole, was used, Comparative Example 1, a control group that did not contain gluconolactone and climbazole, was used. It can be seen that the amount of transepidermal water loss was significantly reduced compared to the case.

(2) Evaluation of scalp thickening and keratin improvement

In order to evaluate the efficacy of improving the thickening keratin of the composition for improving scalp condition of the present disclosure, keratin was collected from the scalp of the test subject and the thickness of the keratin was analyzed.

Scalp thickening keratin was analyzed using Visioscan VC98 (C+K Electronic Co., Germany). For keratin collection and measurement, a special tape, Black D-Squame tape, 0.5 cm X 2.5 cm was prepared and attached to the scalp surface at the 4 intersections of the crown, parietal, frontal, occipital, and midline of the head for 10 seconds. After that, the tape was removed, attached to a Visioscan (CCD-camera), and the amount of keratin collected was measured by photographing. The desquamation index provided after analysis through the software and the total amount of collected keratin are difficult to rule out the interference of hair, so the highest thickening compared to the total area of keratin collected and analyzed (G0+G1+G2+G3+G4) The ratio of keratin (G4) was defined as 'thickened keratin ratio' and the analysis was conducted.

Thickening keratin ratio = G4/(G0+G1+G2+G3+G4)

Parameters such as G0, G1, G2, G3, and G4 are “Relationship between lip skin biophysical and biochemical characteristics with corneocyte unevenness ratio as a new parameter to assess the severity of lip scaling” International Journal of Cosmetic Science, (2021), Vol 43, Issue 3, pages 275-282.

The thickening keratin ratio is expressed as an improvement rate for the measured value before product use (0 weeks), and the formula for obtaining the improvement rate is as follows.

Thickening keratin improvement rate = (a-b) / a X 100

a: Percentage of thickened keratin before product use

b: Percentage of thickened keratin after product use

The measurement results are shown in Table 4 below as an average of 5 people in each Comparative Example 1 group and 6 people in Example 1 group, and representative images of the Example 1 group before and after product use are shown in FIG. 2 .

Thickened keratin improvement rate (%) 0 weeks 1 week 2 weeks Comparative Example 1 - 5.7 5.4 Example 1 - 37.5 50.3

As can be seen in Table 4 and FIG. 2, when Example 1, which is a composition for improving scalp condition containing gluconolactone and climbazole, was used, Comparative Example 1, a control group that did not contain gluconolactone and climbazole, was used. It can be confirmed that the thickened keratin is improved compared to the case.

(3) Interleukin-8 analysis in collected keratin

In order to confirm the efficacy of improving the secretion of inflammatory factors of the composition for improving scalp condition of the present disclosure, the content of interleukin-8 in keratin was analyzed using keratin collected from the scalp of the test subject.

Interleukin-8 (IL-8) is “Dandruff/seborrhoeic dermatitis is characterized by an inflammatory genomic signature and possible immune dysfunction: transcriptional analysis of the condition and treatment effects of zinc pyrithione” British Journal of Dermatology, (2012), Vol 166, It is a representative inflammatory factor known to increase in keratin samples from lesions such as dandruff or seborrheic scalpitis in literature such as Issue S2, pages 33-40.

For keratin collection, a special tape, Black D-Squame tape, 0.5 cm X 2.5 cm was prepared and attached to the scalp surface at the 4 intersections of the crown, parietal, frontal, occipital, and midline of the head for 10 seconds, and then the tape was removed, and the removed keratin was eluted using 1 X PBS containing 0.05% Tween 20 + 0.5 mM EDTA. Keratin was subjected to sonication for 60 minutes with a buffer solution, and the eluted keratin solution was quantitatively analyzed using Human IL-8 ELISA kit (R&D system).

In addition, the total protein amount in the eluted keratin solution was confirmed using the BCA Protein assay (ThermoFisher Scientific), and the amount of IL-8 in the keratin was normalized to the total protein amount and analyzed.

The analysis results of IL-8 are shown in Table 5 below as an average of 5 people in the group of Comparative Example 1 and 6 people in the group of Example 1.

IL-8 / total protein (pg/μg) 0 weeks 1 week 2 weeks Comparative Example 1 0.31 0.09 0.32 Example 1 0.36 0.09 0.08

As can be seen in Table 5, when Example 1, which is a composition for improving scalp condition containing gluconolactone and climbazole, was used, IL was higher than when Comparative Example 1, a control group not containing gluconolactone and climbazole, was used. It can be confirmed that -8 secretion is improved.

(4) sensory evaluation

In order to confirm the efficacy of the composition for improving scalp condition prepared according to the present disclosure, sensory evaluation was performed by surveying the experimenters participating in the evaluation as follows. The evaluation product was the wash-off shampoo type of Comparative Example 1 and Example 1, and after using each product once a day for a week, a questionnaire was conducted to confirm the degree of subjective scalp condition improvement, and the evaluation scale was 0 to 5 points. The self-diagnosis criteria for each item are shown in Table 6 below.

score satisfaction Scalp itchiness improvement Improvement of dead skin cells Improving scalp odor (smell) irritation 1 point very bad scalp is very itchy Scalp dead skin cells have become very severe Daily life is uncomfortable due to scalp odor No scalp irritation at all 2 points bad scalp is itchy Scalp dead skin cells have become a little worse My scalp smells a lot Slight scalp irritation, but barely perceptible 3 points is average is average is average is average There is scalp irritation and it is recognized during daily life 4 points good night Scalp itchiness is relieved Scalp exfoliation was improved Scalp smell improved I have scalp irritation and need improvement 5 points very good Scalp itchiness improved significantly Scalp dead skin cells were greatly improved. Scalp smell improved a lot Severe scalp irritation and discomfort in daily life

The results of the sensory evaluation are shown in Table 7 and FIG. 3 below as averages of 5 people in the group of Comparative Example 1 and 6 people in the group of Example 1, respectively.

satisfaction Scalp itchiness improvement Improvement of dead skin cells scalp odor improvement stimulation Comparative Example 1 2.90 ± 1.02 2.80 ± 1.30 2.80 ± 0.84 2.20 ± 0.84 1.60 ± 0.96 Example 1 3.67 ± 1.08 3.42 ± 1.56 2.92 ± 1.20 3.08 ± 1.02 0.83 ± 0.26

As can be seen in Table 7 and FIG. 3, when Example 1, which is a composition for improving scalp condition containing gluconolactone and climbazole, was used, Comparative Example 1, a control group that did not contain gluconolactone and climbazole, was used. It can be seen that scalp itching, dead skin cells, scalp odor are significantly improved, and scalp irritation is also reduced.

In view of the above experimental results, the composition for improving scalp condition of the present disclosure improved transdermal water loss, thickened keratin, improved IL-8 secretion, improved scalp itching, improved exfoliated keratin through a combination of gluconolactone and climbazol, It can be seen that the scalp odor improvement effect is remarkably excellent.

Preparation Example 1: Composition 1 for Improving Scalp Condition (Shampoo)

ingredient name Weight ratio (%) Comparative Example 1 Example 1 Gluconolactone - 0.5 Climbazole - 0.3 Disodium laureth sulfosuccinate 5 to 10 5 to 10 Lauryl Hydroxysultaine 1 to 5 1 to 5 Sodium Methyl Cocoyl Taurate 1 to 5 1 to 5 Cocamide Methyl MEA 1 to 5 1 to 5 disodium
cocoamphodiacetate 0.1 to 1 0.1 to 1 Purified water balance balance

Preparation Example 2: Composition 2 for improving scalp condition (hair tonic)

A hair tonic composition was prepared by a conventional method using gluconolactone and climbazole according to the prescription shown in Table 9 below.

Ingredients Weight ratio (%) ethanol 55 castor oil 5 glycerin 3 Gluconolactone 0.5 Climbazole 0.3 flavors and colors Appropriate amount Purified water Remaining amount (total 100)

Preparation Example 3: Composition 3 for improving scalp conditions (hair lotion)

A hair lotion composition was prepared using gluconolactone and climbazole according to the prescription shown in Table 10 in a conventional manner.

Ingredients Weight ratio (%) Cetostearyl Alcohol 2 Stearyltriethylammonium chloride 2 Hydroxyethyl Cellulose 0.5 Gluconolactone 10 Climbazole 0.5 flavors and colors Appropriate amount Purified water Remaining amount (total 100)

Claims (10)

Contains gluconolactone and climbazole as active ingredients,
A composition for improving scalp conditions wherein the weight ratio of gluconolactone and climbazole is 1:0.4 to 0.8 (gluconolactone: climbazole). The composition for improving scalp condition according to claim 1, wherein the gluconolactone is 0.001 to 20% by weight based on the total weight of the composition. The composition for improving scalp condition according to claim 1, wherein the Climbazole is 0.001 to 20% by weight based on the total weight of the composition. delete The composition for improving scalp condition according to claim 1, wherein the composition inhibits the secretion of inflammatory factors. The composition for improving scalp conditions according to claim 1, wherein the composition strengthens the scalp barrier by improving scalp moisture loss. The composition for improving scalp conditions according to claim 1, wherein the composition is for improving dandruff, improving scalp thickening, keratin, or keratin exfoliation symptoms. The composition for improving scalp condition according to claim 1, wherein the composition is a cosmetic composition. A hair or scalp product comprising the composition for improving scalp condition according to claim 1. The method of claim 9, wherein the product is a scalp clinic agent, scalp scaling agent, scalp massage agent, scalp care agent, cleanser, shampoo, tonic, hair conditioner, hair lotion, gel, pack, cream, essence, powder, spray, oil A product for hair or scalp selected from the group consisting of soap, ointment, hair styling agent, hair growth agent, hair dye agent and perm agent.