KR101848474B1 - Nature-derived cosmetic composition for relieving itching of atopic skin and the method for preparing the same - Google Patents

Abstract

The present invention relates to a nature-derived cosmetic composition for relieving itching of atopic skin. The nature-derived cosmetic composition according to the present invention exhibits an effect of reducing the amount of percutaneous water loss and reducing skin itching in a test subject exhibiting symptoms of atopic dermatitis, thereby being applied as a cosmetic for preventing or improving itching caused by atopic skin.

Description

[0001] The present invention relates to a natural-derived cosmetic composition for alleviating atopic skin itching and a method for preparing the same,

The present invention relates to a natural-derived cosmetic composition for alleviating atopic skin itching.

Atopic dermatitis is a chronic, recurrent inflammatory skin disease that usually begins in infancy or childhood, with pruritus (itching), dry skin, and characteristic eczema (Seoul National University Hospital, Seoul National University Hospital). In infancy, it begins with eczema on the unfolded side of the face and limbs, but it appears as a form of eczema on the part where the arm is bent and on the bending part behind the knee in growth, and in many cases it tends to improve naturally . In adults, lichenification appears in which the skin folds up, and eczema is more common on the face than in childhood. Atopic dermatitis is a worldwide increasing trend and its prevalence is reported to be 20% of the population.

The cause of atopic dermatitis has not been known yet. Clinical symptoms vary widely from dry skin to eczema. Therefore, the cause of the disease can not be explained by any single cause, but environmental factors, genetic predisposition, immunological response, and skin barrier abnormalities are considered to be the main causes. Environmental factors include environmental pollution caused by industrialization, increase in the use of food additives, increase in use of carpet, bed, sofa due to western type of residence, cause of allergy such as house dust mite due to rise of room temperature (allergen ). The fact that atopic dermatitis is genetically affected can be seen in the fact that many patients with atopic dermatitis have family history.

In order to treat atopic dermatitis, antihistamines are used to treat dry skin, corticosteroids for treatment of dermatitis, immunomodulators, topical immunomodulators and itch, and allergens, irritants, There is a multifaceted treatment method to avoid stress, but there is no clear treatment method to date.

Korean Patent Publication No. 10-2016-0089256 Korean Patent No. 10-0813781

It is an object of the present invention to provide a method for producing a cosmetic composition for improving the itching of atopic skin.

Another object of the present invention is to provide a cosmetic composition for improving the itchiness of atopic skin prepared by the method according to the present invention.

The present invention relates to a method for the treatment and / or prophylaxis of various diseases, such as jojoba seed oil, D-panthenol, allantoin, petiole extract, mulberry extract, cholesterol, buttercup extract, orange peel oil, Atlas cider peel oil, Mixing the alanylglutamine to prepare a composition; And

Cooling the prepared composition to 1 to 5 DEG C, and irradiating the microwave for 10 minutes to 24 hours at 300 W. The present invention also provides a method for preparing the composition for improving the itchiness of atopic skin.

Wherein the cosmetic composition comprises 1 to 30% by weight of jojoba seed oil, 1 to 20% by weight of D-panthenol, 1 to 20% by weight of allantoin, 1 to 20% by weight of cepa extract, 1 to 20% 1 to 20% by weight of cholesterol, 1 to 20% by weight of caterpillar extract, 1 to 10% by weight of orange peel oil, 1 to 10% by weight of Atlas cider peel oil, 1 to 10% by weight of damask rose oil, To 5 wt%, glycerin 1 to 5 wt%, and alanyl glutamine 1 to 2 wt%.

The cosmetic composition may be one selected from the group consisting of a soothing gel, a lotion, a cream, a facial cream, a lotion, an essence, a cleansing cream, a cleansing foam, a cleansing water, a pack, a powder or a body oil.

The present invention provides a cosmetic composition for improving the itchiness of atopic skin prepared by the method according to the present invention.

The cosmetic composition according to the present invention can be applied as a cosmetic for preventing or ameliorating itching caused by atopic skin, since the natural-derived cosmetic composition exhibits a reduction in transdermal water loss and an improvement in skin itching in a test subject exhibiting symptoms of atopic dermatitis.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic view of a method for producing a cosmetic composition for improving the itchiness of atopic skin according to the present invention. FIG.

The present invention relates to a method for the treatment and / or prophylaxis of various diseases, such as jojoba seed oil, D-panthenol, allantoin, petiole extract, mulberry extract, cholesterol, buttercup extract, orange peel oil, Atlas cider peel oil, Mixing the alanylglutamine to prepare a composition; And

Cooling the prepared composition to 1 to 5 DEG C, and irradiating the microwave for 10 minutes to 24 hours at 300 W. The present invention also provides a method for preparing the composition for improving the itchiness of atopic skin.

In the present invention, "atopic skin itching relief" means reducing or improving the itching caused by atopic dermatitis, and is also described herein as "improvement of itchiness of atopic skin ".

Wherein the cosmetic composition comprises 1 to 30% by weight of jojoba seed oil, 1 to 20% by weight of D-panthenol, 1 to 20% by weight of allantoin, 1 to 20% by weight of cepa extract, 1 to 20% 1 to 20% by weight of cholesterol, 1 to 20% by weight of caterpillar extract, 1 to 10% by weight of orange peel oil, 1 to 10% by weight of Atlas cider peel oil, 1 to 10% by weight of damask rose oil, To 5 wt%, glycerin 1 to 5 wt%, and alanyl glutamine 1 to 2 wt%.

It is possible to apply various kinds of cosmetics to the cosmetics without any irritation without imparting a feeling of rejection inherent to the plant within the above-mentioned numerical range. And it has no influence on the stability. Therefore, the numerical limitation is significant.

In one embodiment of the present invention, the extracts of papouwood, mulberry and parsley are obtained by hot water extraction at 80 to 90 ° C in distilled water, and the oils of jojoba seed, orange peel, Atlas cider peel, Commercially available products were purchased and obtained.

In the present invention, "papo tree" is a kind of deciduous herbaceous plant belonging to the family Annapella (Annonaceae), also known as papaya, including trees and shrubs, or rare tropical clams. They are native to tropical climate regions, and some are also distributed in temperate climates.

After the composition is cooled to 1 to 5 ° C, the microwave irradiation at 300 W for 10 minutes to 24 hours causes the composition to overheat upon irradiation with microwave at room temperature. As a result, the vitamins and proteins This is done to minimize the loss, and it is possible to maximize the effect of the usability by microwave irradiation after cooling.

The cosmetic composition may be one selected from the group consisting of a soothing gel, a lotion, a cream, a facial cream, a lotion, an essence, a cleansing cream, a cleansing foam, a cleansing water, a pack, a powder or a body oil.

The cosmetic composition may be prepared by dissolving or dispersing at least one compound selected from the group consisting of a fatty substance, an organic solvent, a solubilizer, a thickening agent, a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, Such as cosmetics or skin, such as fillers, sequestering agents, chelating agents, preservatives, vitamins, barrier agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or any other ingredient commonly used in cosmetics And may contain adjuvants conventionally used in the scientific field. Such adjuvants are introduced in amounts commonly used in the cosmetics or dermatological fields.

The external form of the cosmetic composition contains a cosmetically or dermatologically acceptable medium or base. It may be in any form suitable for topical application, for example, as a solution, a gel, a solid, a paste anhydrous product, an emulsion obtained by dispersing the oil phase in water, a suspension, a microemulsion, a microcapsule, In the form of a non-ionic follicle dispersing agent, or in the form of creams, skins, lotions, powders, ointments, sprays or conical sticks. These compositions may be prepared according to conventional methods in the art. The composition according to the invention may also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

The cosmetic composition containing the active ingredient according to the present invention is not particularly limited in its formulation. For example, supplements such as soymilk, softening longevity, convergent lotion, nutritional lotion, lotion, cream, facial cream, nutritional cream, massage cream, essence, cleansing cream, cleansing foam, cleansing water, pack, powder, body lotion, body cream, body Oil or body essence and is preferably selected from the group consisting of a soothing gel, a lotion, a cream, a facial cream, a lotion, an essence, a cleansing cream, a cleansing foam, a cleansing water, a pack, a powder or a body oil Or < / RTI >

In one embodiment of the invention, the cosmetic composition is formulated as a soothing gel, lotion, cream or facial cream.

In addition, the composition can be used as a formulation for absorbing the skin, but it is not limited to the composition of the absorbent gel, pad, patch, sponge and mask pack.

The cosmetic composition as described above may be applied to the skin, or may be applied to the inside of the skin using a micro needle or the like.

The cosmetic composition for improving the itchiness of the atopic skin may contain 0.0000001 to 10% by weight (1ng / ml to 100mg / ml) based on the total weight of the cosmetic composition, but is not limited thereto.

The present invention provides a cosmetic composition for improving the itchiness of atopic skin prepared by the method according to the present invention.

The cosmetic composition for improving the itchiness of atopic skin according to the present invention exhibits an effect of reducing the transdermal water loss and improving the skin itching in the test subject who exhibits symptoms of atopic dermatitis. Therefore, the cosmetic composition for preventing or ameliorating itchiness caused by atopic skin It can be applied as cosmetics.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail with reference to the following examples. However, the following examples are intended to illustrate the contents of the present invention, but the scope of the present invention is not limited to the following examples. Embodiments of the present invention are provided to more fully describe the present invention to those skilled in the art.

Example 1 Preparation of a Composition Containing a Plant Extract

At room temperature, 20 wt% of jojoba seed oil, 10 wt% of D-panthenol, 10 wt% of allantoin, 10 wt% of cepomoe extract, 10 wt% of mulberry extract, 10 wt% of cholesterol, 10 wt% , 5% by weight of Atlas cider peel oil, 5% by weight of damask rose oil, 2% by weight of peanut oil, 2% by weight of glycerin and 1% by weight of alanyl glutamine, After cooling to 5 캜, microwaves were irradiated at 300 W for 10 minutes to 24 hours.

The extracts of papouwood, mulberry and millet were obtained by hot water extraction at 80 to 90 캜 in distilled water. Jojoba seeds, orange peel, atlas cider peel, damask rose flower and peanut oil were obtained by purchasing a commercial product.

≪ Preparation Examples 1 to 4 > Cosmetic preparations containing plant extracts

Cosmetics containing the composition of Example 1 were each prepared as Formulation of soothing gel (Preparation Example 1), lotion (Preparation Example 2), cream (Preparation Example 3) and facial cream (Preparation Example 4) as shown in Table 1 below. (Comparative Example 1), lotion (Comparative Example 2), cream (Comparative Example 3), and facial cream (Comparative Example 4) were prepared in the same manner as in Example 1 except that the cosmetic comprising the composition without microwave irradiation Respectively, and they are shown as a control group in the following experimental examples.

Component (% by weight) Soothing gel (Preparation Example 1) Lotion (Preparation Example 2) Cream (Preparation Example 3) Facial cream (Preparation Example 4) The composition of Example 1 0.01 0.01 0.01 0.01 Amino acid stark (stock) 0.05 0.05 0.05 0.05 Mineral mixture 0.0007 0.0007 0.0007 0.0007 1,3-butylene glycol 10 10 - - Mineral oil - 5 10 7 Olive oil wax - - 3 3 Cetyl alcohol 2 2 2 2 Xanthan gum 0.5 0.5 - 0.5 Purified water Balance Balance Balance Balance

≪ Experimental Example 1 >

22 children aged 5 to 7 years with atopic dermatitis (age: 4 years old, 2 years old, 5 years old 13 years old, 6 years old 7 years old (average 5.23 years old) The test items were measured before the use of the product, after 2 weeks of use, and after 4 weeks of use, while the test products, Production Examples 1 to 4, were used for 4 weeks on the forearm or face, After the test, the questionnaire evaluation was completed. No subjects were included in the questionnaire on the atopic skin disease, itching, stinging, erythema, cosmetic side effects, side effects of medicines, and photosensitivity experiences.

The subjects were given Preparation Examples 1 to 3 and Comparative Examples 1 to 3 in an amount corresponding to the order of the soothing gel, lotion and cream in the forearm, followed by sufficiently tapped. In Preparation Example 4 and Comparative Example 4, an appropriate amount of the composition was applied to the face, and the composition was sufficiently tapped.

< Experimental Example  2> Evaluation of itching relief

For the mechanical evaluation, the subjects were stabilized for 30 minutes in a room with constant temperature and humidity conditions of room temperature 20 ~ 25 ℃ and humidity 40 ~ 60% to adapt skin surface temperature and humidity to the environment of measuring space, The water intake was limited during this period. For the objective measurement, one researcher measured the same area at each measurement.

<2-1> Measurement of Transepidermal Water Loss

Percutaneous water loss was measured by using a vapometer to measure the dry area of the forearm. Measurements were taken 3 times and measured for 10 seconds. TEWL indicates the amount of water loss (g / h.m²) through the skin, and the lower the value, the better the skin condition.

As a result, as shown in Tables 2 and 3, TEWL was significantly decreased (p < 0.025) after 2 weeks of use and 4 weeks after use compared with before use, and the comparative example showed a significant difference between before and after use There was no.

Manufacturing example g / h.m &lt; 2 &gt; (Mean + SD) Before use 10.36 + - 2.41 After 2 weeks of use 8.46 ± 2.19 After 4 weeks of use 7.58 ± 1.60 In-group comparison

Probability of significance

Test the effect within an object 0.000 # Before use - After 2 weeks of use 0.001 # Before use - After 4 weeks of use 0.000 #

Comparative Example g / h.m &lt; 2 &gt; (Mean + SD) Before use 10.36 + - 2.41 After 2 weeks of use 10.16 ± 1.02 After 4 weeks of use 9.74 ± 1.77 In-group comparison Probability of significance Before use - After 2 weeks of use / Before use - After 4 weeks of use /

#: P <0.025 (= 5% / 2) by Friedman test and Boncotroni corrected post hoc Wilcoxon signed rank test

<2-2> Visual Analog Scale Assessment

The test subjects directly displayed the degree of itching before and after using the test subject on the 0-10 cm line segment and compared the length of the displayed line segments to evaluate the degree of itching improvement.

As a result, as shown in Table 4 and Table 5, the degree of skin itching was significantly reduced (p < 0.025) after 2 weeks and 4 weeks after use, There was no significant difference.

Manufacturing example cm (Mean ± SD) Before use 5.29 ± 1.88 After 2 weeks of use 2.59 ± 1.77 After 4 weeks of use 1.50 ± 1.63
In-group comparison
Probability of significance Test the effect within an object 0.000 # Before use - After 2 weeks of use 0.000 # Before use - After 4 weeks of use 0.000 #

Comparative Example cm (Mean ± SD) Before use 5.29 ± 1.88 After 2 weeks of use 4.71 ± 1.02 After 4 weeks of use 4.14 ± 1.33 In-group comparison Probability of significance Before use - After 2 weeks of use / Before use - After 4 weeks of use /

#: P <0.025 (= 5% / 2) by Friedman test and Boncotroni corrected post hoc Wilcoxon signed rank test

<2-3> Global Assessment of Efficacy

Manufacturing Example Answers to the questionnaire data in five steps: Excellent (4), Good (3), Normal (2), Bad (1), and Very Bad (0) for improvement of skin itching and skin dryness after use Respectively. The percentages of test subjects for each answer were determined to determine the efficacy of the preparation.

As a result, as shown in Table 6 and Table 7, 100% of the test subjects were evaluated to be more than average in terms of improvement of skin itching and skin dryness after applying soymilk, lotion, cream and facial cream of Preparation Examples 1 to 4. However, for Comparative Examples 1 to 4, most of the test subjects were rated below the average as shown in Tables 8 and 9.

Production Examples 1 to 3 Number of subjects Average 5 * 4* 3 * 2* One* Soothing gel, lotion,
cream
(Forearm) Improved skin itching 14 6 2 0 0 3.55 Improved skin dryness 14 7 One 0 0 3.59 * 5: Very good, 4: Good, 3: Fair, 2: Bad, 1: Very poor

Production Example 4 Number of subjects Average 5 * 4* 3 * 2* One* Facial cream
(Face) Improved skin itching 13 8 One 0 0 3.55 Improved skin dryness 13 8 One 0 0 3.55 * 5: Very good, 4: Good, 3: Fair, 2: Bad, 1: Very poor

Comparative Examples 1 to 3 Number of subjects Average 5 * 4* 3 * 2* One* Soothing gel, lotion,
cream
(Forearm) Improved skin itching 0 0 8 9 5 2.13 Improved skin dryness 0 0 7 10 5 2.09 * 5: Very good, 4: Good, 3: Fair, 2: Bad, 1: Very poor

Comparative Example 4 Number of subjects Average 5 * 4* 3 * 2* One* Facial cream
(Face) Improved skin itching 0 0 6 12 4 2.09 Improved skin dryness 0 0 7 12 3 2.18 * 5: Very good, 4: Good, 3: Fair, 2: Bad, 1: Very poor

<2-4> Evaluation of stability and adverse reaction

The safety of the manufacturing examples was evaluated by collecting the results of the visual evaluation of the researchers and the results of the test subjects' questionnaire about the parts of the manufacturing example used for all the test subjects using the manufacturing examples. During the test period, abnormal skin conditions that occurred during the use of the product were surveyed and the degree of symptoms and symptoms were confirmed.

As a result, there were no reports of specific skin adverse reactions including erythema, edema, and dysgenesis during the period during which the test subjects were using the manufacturing examples. No abnormal findings were observed on physical examination by a dermatologist.

In addition, the safety questionnaire for the subjects showed no specific symptoms related to skin adverse reactions, including itching, soreness, burning sensation, stiffness, and tingling.

Claims (4)

1 to 20 wt% of jojoba seed oil, 1 to 20 wt% of D-panthenol, 1 to 20 wt% of allantoin, 1 to 20 wt% of cepomoe extract, 1 to 20 wt% of mulberry extract, cholesterol 1 1 to 10% by weight of peanut oil, 1 to 10% by weight of peanut oil, 1 to 10% by weight of peanut oil, 1 to 10% 1 to 5% by weight of glycerin, and 1 to 2% by weight of alanyl glutamine to prepare a composition; And
Cooling the prepared composition to 1 캜 and irradiating microwave at 300 W for 10 minutes to 24 hours; A method for improving the itchiness of atopic skin, and a method for producing a cosmetic composition for skin moisturization improvement. delete The cosmetic composition according to claim 1, wherein the cosmetic composition is one selected from the group consisting of a soothing gel, a lotion, a cream, a facial cream, a lotion, an essence, a cleansing cream, a cleansing foam, a cleansing water, a pack, Wherein the atopic skin has an itching effect and the skin moisturizing effect is improved. A cosmetic composition for improving the itchiness of atopic skin and for improving skin moisturization, which is produced by the method according to claim 1 or 3.

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