CN111228153A - Composition with synergistic acne removing effect, cosmetic composition and preparation method thereof - Google Patents
Composition with synergistic acne removing effect, cosmetic composition and preparation method thereof Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a composition with a synergistic acne removing effect, a cosmetic composition and a preparation method thereof, and relates to the technical field of daily skin care. According to the invention, by the proper proportion of PCA zinc, the wrapping salicylic acid, the quaternary ammonium salt-73, the nicotinamide and the tea tree essential oil in the composition, the composition can achieve the synergistic effects of oil control, cutin removal, antibiosis, inflammation diminishing and the like, so that the effect of safely and effectively removing acnes is achieved. The composition with the synergistic acne removing effect is applied to cosmetics, so that the cosmetics have the effects of diminishing inflammation and removing acnes, and the preparation method of the cosmetic composition is simple and is suitable for industrial production.
Description
Technical Field
The invention relates to the technical field of daily skin care, and particularly relates to a composition with a synergistic acne removing effect, a cosmetic composition and a preparation method of the composition.
Background
Acne is a chronic inflammatory skin disease involving sebaceous glands, mainly turns into comedo, papule, pustule, nodulocyst and the like, and leaves vasodilatation and scar formation after partial healing.
The causes of acne are mainly: 1. hypersecretion of sebum; 2. the sebaceous gland duct is excessively coked to cause the fallen keratinocytes, the original bacteria of the pilosebaceous gland and the sebum mixture to be accumulated at the hair follicle mouth to form acne; 3. acne is caused by skin damage caused by bacteria and fungi such as propionibacterium acnes, pityrosporum orbicularis, staphylococcus epidermidis and the like; 4. an immune response; 5. insufficient sleep; 6. spicy food, etc.
At present, acne-removing skin care products in the market are various in types, but the skin care products mostly have the problems of single effect, strong irritation and the like, and the effects of the skin care products cannot meet the requirements of consumers, so people urgently need to find a cosmetic with an acne-removing effect, which has comprehensive and safe effects, no adverse reaction and definite effect.
Disclosure of Invention
The technical problem to be solved by the invention is at least one problem in the background technology, and the composition and the cosmetic composition with the synergistic acne-removing effect are provided, and the composition achieves the safe and effective acne-removing effect through the synergistic effects of multiple effects of oil control, cutin removal, antibiosis, inflammation diminishing and the like; the composition can be used for preparing cosmetic composition.
The invention also aims to provide a preparation method of the cosmetic composition with the synergistic acne removing effect.
In order to solve the above problems, the present invention proposes the following technical solutions:
a first aspect. The invention provides a composition with a synergistic acne removing effect, which comprises the following components in parts by weight:
the further technical scheme is that the composition with the synergistic acne removing effect comprises the following components in parts by weight:
the further technical proposal is that the nicotinic acid content of the nicotinamide is lower than 100 PPM.
The invention also provides application of the composition with the synergistic acne removing effect in acne removing and inflammation diminishing cosmetics.
The composition with the synergistic acne removing effect is applied to preparation of at least one dosage form of skin cream, skin care lotion, skin care gel, sleep mask, skin care essence or skin care water.
In a second aspect, the present invention provides a cosmetic composition with a synergistic acne removing effect, comprising the composition with a synergistic acne removing effect as described in the first aspect.
The further technical scheme is that the cosmetic composition with the synergistic acne removing effect comprises the following components in percentage by mass:
the cosmetic auxiliary material matrix is selected from one or more of a surfactant, a solubilizer, a thickening agent, a conditioner, a humectant, grease, a preservative, a chelating agent, essence and deionized water.
The cosmetic auxiliary material matrix is selected from a surfactant, a solubilizer, a thickening agent, a conditioning agent, a polyol humectant, grease, a preservative, a chelating agent, essence and deionized water.
In a third aspect, the present invention also provides a method for preparing the cosmetic composition with synergistic acne removing effect according to the second aspect, comprising the steps of:
1) dissolving the PCA zinc and the wrapping salicylic acid and the nicotinamide by deionized water according to the proportion, and uniformly mixing;
2) dissolving quaternary ammonium salt-73 in a polyol humectant at 70-90 ℃, cooling, and adding into the product obtained in the step 1);
3) dissolving tea tree essential oil in advance by using a solubilizer, uniformly mixing, and adding the mixture into the product obtained in the step 2);
4) adding the rest components, and stirring well to obtain the cosmetic composition with synergistic acne removing effect.
Compared with the prior art, the invention can achieve the following technical effects: in the composition with the synergistic acne removing effect, the contained PCA zinc is an important component of a natural humectant of Natural Moisturizing Factors (NMF) inherent in skin, and can help the hydration function of stratum corneum to be normalized, regulate sebum secretion and improve the phenomenon of excessive sebum secretion; the encapsulated salicylic acid has high activity content, good water solubility, long-lasting effect slow release and low irritation; the relieving effect is good; the quaternary ammonium salt-73 has high-efficiency antibacterial activity under the condition of extremely low dosage, and has the function of inhibiting the generation of melanin; the nicotinamide can effectively reduce the formation and discharge of sebum and has obvious effect on inflammatory acne; the tea tree essential oil has antibacterial and anti-inflammatory effects, has strong permeability, and can quickly permeate into hair follicles for conditioning.
According to the composition, the PCA zinc, the wrapping salicylic acid, the quaternary ammonium salt-73, the nicotinamide and the tea tree essential oil are mixed in proportion, so that the synergistic effects of oil control, cutin removal, antibiosis, inflammation diminishing and the like can be achieved, and the effect of safely and effectively removing acnes is achieved. The composition with the synergistic acne removing effect is applied to cosmetics, so that the cosmetics have the effects of diminishing inflammation and removing acnes, and the preparation method of the cosmetic composition is simple and is suitable for industrial production.
Detailed Description
The technical solutions in the examples will be clearly and completely described below. It is apparent that the embodiments to be described below are only a part of the embodiments of the present invention, and not all of them. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It will be understood that the terms "comprises" and/or "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It is also to be understood that the terminology used in the description of the embodiments of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the embodiments of the invention. As used in the description of embodiments of the present invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
The embodiment provides a composition with a synergistic acne removing effect, which comprises the following components in parts by weight:
wherein the PCA zinc is an important component of a natural humectant of Natural Moisturizing Factor (NMF) inherent in skin, and can help the normalization of hydration function of stratum corneum, regulate sebum secretion, and improve excessive sebum secretion.
Furthermore, the encapsulated salicylic acid adopted by the invention has high activity content, good water solubility, lasting slow release effect and low irritation.
Furthermore, the quaternary ammonium salt-73 adopted in the composition is a high-purity raw material, so that the composition meets the requirement that the Japanese quasi-drug is used in an acne-removing product, has high-efficiency antibacterial activity under the condition of extremely low dosage, and has the effect of inhibiting melanin generation.
Furthermore, the nicotinamide adopted in the composition is a high-purity raw material, the nicotinic acid content of the nicotinamide is lower than 100PPM, the nicotinamide can effectively reduce the formation and discharge of sebum, and the effect on inflammatory acne is obvious.
Furthermore, the tea tree essential oil adopted in the composition is derived from Australia, has the effects of resisting bacteria and inflammation, has strong penetrability, and can quickly permeate into hair follicles for conditioning.
According to the embodiment of the invention, by the proportion of PCA zinc, the wrapping salicylic acid, the quaternary ammonium salt-73, the nicotinamide and the tea tree essential oil, the multi-effect synergistic effect of controlling oil, removing cutin, resisting bacteria, diminishing inflammation and the like can be achieved, and the cosmetic has a safe and effective acne removing effect when being added into the cosmetic.
The composition with the synergistic acne removing effect provided by the embodiment can be applied to preparation of dosage forms such as skin care lotion, skin care cream, skin care gel, sleep mask, skin care essence or skin care water.
The embodiment of the invention also provides a cosmetic composition with a synergistic acne removing effect, which comprises the following components in percentage by mass:
when the composition with the synergistic acne removing effect is applied to cosmetics, the composition also comprises a cosmetic auxiliary material matrix for matching use.
The cosmetic auxiliary material matrix comprises: surfactant, solubilizer, thickener, conditioner, humectant, oil, antiseptic, chelating agent, essence, deionized water, etc. Those skilled in the art can select appropriate cosmetic adjuvant matrix according to the cosmetic dosage form to be prepared, wherein the dosage of surfactant, solubilizer, thickener, conditioner, humectant, oil, preservative, chelating agent, essence, deionized water, etc. is well known to those skilled in the art.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The embodiment of the invention provides a cosmetic composition with a synergistic acne removing effect, which is prepared into acne removing essence water, and the contents of the raw material component proportion, the raw material component proportion of a control example and the raw material component proportion of a blank example are shown in the following table 1.
Table 1 acne-removing essence (unit: mass%) of examples 1 to 2, comparative examples 1 to 5 and blank example
The preparation process method of the acne-removing essence can be expressed as follows:
1) a, putting deionized water into a water aqua pot, adding EDTA-2NA, allantoin, xanthan gum pre-dispersed by glycerol and hydroxyethyl cellulose, heating to 85 ℃, preserving heat and stirring for 20 minutes;
2) b, dispersing quaternary ammonium salt-73 in 1, 3-butanediol, dissolving at 85 ℃, and cooling;
3) c: dissolving the tea tree essential oil by using a solubilizer;
4) cooling to 40 deg.C, adding PCA zinc, nicotinamide, coated salicylic acid, raw materials B and C, and essence/solubilizer/antiseptic; stirring for 20 minutes, and discharging after the inspection is qualified.
The composition with synergistic acne removing effect contains PCA zinc, salicylic acid, quaternary ammonium salt-73, nicotinamide and tea tree essential oil.
Effect test (evaluation of acne removing effect)
1. The tester: 80 testers (16-25 years old) are divided into 8 groups, and each group contains 10 testers; each group used the same formulation.
2. Test area: the pox part of the face;
3. use of: twice a day in the morning and evening for 2 weeks;
4. evaluation method: filling in a questionnaire;
5. the test results are shown in table 2 below.
Table 2 shows the results of the evaluation of the acne removing effect in examples 1-2, comparative examples 1-5 and blank examples
| Sample set | Good effect | In general | Without effect |
| Comparative example 1 | 2 | 5 | 3 |
| Comparative example 2 | 3 | 6 | 2 |
| Comparative example 3 | 3 | 6 | 2 |
| Comparative example 4 | 2 | 4 | 4 |
| Comparative example 5 | 1 | 4 | 5 |
| Example 1 | 6 | 4 | 0 |
| Example 2 | 8 | 2 | 0 |
| Blank group | 0 | 1 | 9 |
The results in table 2 show that the cosmetic composition with synergistic acne removing effect provided by the invention has a relatively significant acne removing effect through the synergistic effect of the components, and the effect is more obvious than that of a single acne removing component.
Example 3
A cosmetic composition with synergistic acne removing effect is prepared into acne removing lotion, and the content of the raw material components, the raw material components of the control example and the blank example is shown in the following tables 3-1, 3-2 and 3-3. .
TABLE 3-1 acne removing lotion of comparative examples 6-13 (unit: mass%)
TABLE 3-2 acne removing lotion of comparative examples 14-21 (unit: mass%)
Tables 3 to 3 acne-removing lotions of example 3, comparative examples 22 to 28 and blank example (unit: mass%)
The preparation process method of the acne-removing lotion can be expressed as follows:
1) a: putting deionized water into a water phase pot, uniformly dispersing carbomer in water, stirring until the carbomer is completely swelled, adding xanthan gum pre-dispersed by glycerol, adding EDTA-2NA, allantoin and PCA zinc, heating to 85 ℃, keeping the temperature and stirring for 20 minutes;
2) b: putting the 8-13 materials into an oil phase pot, heating to 80 ℃, and dissolving uniformly;
3) pumping the materials in the water phase pot and the oil phase pot into an emulsifying pot, stirring and homogenizing for 3 minutes, starting cooling water, cooling to 65 ℃, adding triethanolamine, and continuing stirring and cooling;
4) c: dispersing quaternary ammonium salt-73 in 1, 3-butanediol, dissolving at 85 deg.C, and cooling;
5) d: the package salicylic acid and the nicotinamide are dissolved uniformly by the deionized water;
6) cooling to 45 deg.C, adding C, D, tea tree essential oil, essence/solubilizer/antiseptic; stirring for 20 minutes, cooling to room temperature, and discharging after qualified inspection.
The composition with synergistic acne removing effect contains PCA zinc, salicylic acid, quaternary ammonium salt-73, nicotinamide and tea tree essential oil.
Effect test (evaluation of acne removing effect)
1. The tester: 200 testers (16-25 years old) are divided into 25 groups, and each group comprises 8 testers; each group used the same formulation.
2. Test area: the pox part of the face;
3. use of: twice a day in the morning and evening for 2 weeks;
4. evaluation method: filling in a questionnaire;
5. the test effects are shown in table 4 below.
Table 4 shows the results of evaluation of the acne removing effect of the acne removing lotions of example 3, comparative examples 6 to 28 and blank example
The results in table 4 show that the cosmetic composition with synergistic acne removing effect provided by the invention has a relatively significant acne removing effect through the synergistic effect of the components, and the acne removing effect is more obvious than that of the cosmetic composition containing only two, three or four components.
Safety test
1. The number of tested persons: 30 persons in total, 10 persons in male, 20 persons in female; minimum age: 22 years old, maximum age: age 40; mean age 28.53 ± 4.45 years volunteer enrollment criteria.
2. The test method comprises the following steps: examples 1-3 spot test. Selecting a qualified spot tester, placing about 0.020-0.025 mL of a tested object into the spot tester by using a closed spot test method, externally applying a medical adhesive tape to the back of the tested object, removing the tested object after 24 hours, observing skin reactions 0.5, 24 and 48 hours after the spot is removed, and recording the results according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition).
3. The evaluation criteria are shown in Table 5 below.
4. The evaluation results are shown in Table 6.
TABLE 5 grading Standard of adverse skin reactions
TABLE 6 safety test results
| Grade of rating | Example 1 | Example 2 | Example 3 |
| 0.5(h) | 0 | 0 | 0 |
| 24(h) | 0 | 0 | 0 |
| 48(h) | 0 | 0 | 1 |
Note that the scoring scale results are average scores.
The results in table 6 show: in the human skin closed patch test, no positive reaction is found in 30 persons, and the test substance does not cause adverse skin reactions to the batch of test subjects according to the regulation in technical Specification for cosmetic safety (2015 edition).
Stability test
1. Stability test samples: example 2, example 3 product.
2. The test method comprises the following steps: the internal control standard (illumination for 1 month and high and low temperature test for 3 months) is higher than the national standard and the industrial standard.
3. The test results are shown in tables 7 and 8 below;
4. the test results are as follows
TABLE 7 photostability results under high and low temperature test conditions
TABLE 7 stability results under high temperature, Low temperature and light test conditions
The results in tables 7-8 show that: the cosmetic composition with the synergistic acne removing effect provided by the invention has good stability in product application.
In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.
While the invention has been described with reference to specific embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. The composition with the synergistic acne removing effect is characterized by comprising the following components in parts by weight:
2. the composition with synergistic acne removing effect according to claim 1, wherein the composition with synergistic acne removing effect comprises the following components in parts by weight:
3. the composition with synergistic anti-acne effect according to claim 1 or 2, characterized in that the niacin content of the niacinamide is lower than 100 PPM.
4. Use of the composition with synergistic acne removing effect according to any one of claims 1 to 3 in acne removing and anti-inflammatory cosmetics.
5. The composition with synergistic acne removing effect according to claim 4 is applied to at least one dosage form of skin cream, skin lotion, skin gel, sleep mask, skin essence or skin lotion.
6. A cosmetic composition having a synergistic acne removing effect, comprising the composition having a synergistic acne removing effect according to any one of claims 1 to 3.
7. The cosmetic composition with the synergistic acne removing effect according to claim 6, which comprises the following components in percentage by mass:
8. the cosmetic composition with synergistic acne removal effect of claim 7, wherein the cosmetic adjuvant matrix is selected from one or more of surfactants, solubilizers, thickeners, conditioners, moisturizers, fats and oils, preservatives, chelating agents, fragrances, deionized water.
9. The cosmetic composition with synergistic acne removal effect of claim 8 wherein the cosmetic adjunct base is selected from the group consisting of surfactants, solubilizers, thickeners, conditioners, polyol moisturizers, fats and oils, preservatives, chelating agents, fragrances, and deionized water.
10. A method for preparing the cosmetic composition having the synergistic acne removing effect of claim 9, comprising the steps of:
1) dissolving the PCA zinc and the wrapping salicylic acid and the nicotinamide by deionized water according to the proportion, and uniformly mixing;
2) dissolving quaternary ammonium salt-73 in a polyol humectant at 70-90 ℃, cooling, and adding into the product obtained in the step 1);
3) dissolving tea tree essential oil in advance by using a solubilizer, uniformly mixing, and adding the mixture into the product obtained in the step 2);
4) adding the rest components, and stirring well to obtain the cosmetic composition with synergistic acne removing effect.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111714404A (en) * | 2020-08-13 | 2020-09-29 | 广州市科能化妆品科研有限公司 | Acne-removing composition and preparation method and application thereof |
| CN112043616A (en) * | 2020-10-21 | 2020-12-08 | 烟台新时代健康产业日化有限公司 | Anti-acne compound and anti-acne essence based on slow release technology |
| CN113440432A (en) * | 2021-06-25 | 2021-09-28 | 广州市科能化妆品科研有限公司 | Acne-removing conditioner, acne-removing mask composition and preparation method thereof |
| CN115068372A (en) * | 2022-06-01 | 2022-09-20 | 广州云也品牌管理有限公司 | Penetration-promoting composition and preparation method thereof |
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| CN111714404A (en) * | 2020-08-13 | 2020-09-29 | 广州市科能化妆品科研有限公司 | Acne-removing composition and preparation method and application thereof |
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| CN115068372A (en) * | 2022-06-01 | 2022-09-20 | 广州云也品牌管理有限公司 | Penetration-promoting composition and preparation method thereof |
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